Publication date: Available online 13 November 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Sylvia J. Gasparini, Sílvia Llonch, Oliver Borsch, Marius AderAbstractThe mammalian retina displays no intrinsic regenerative capacities, therefore retinal degenerative diseases such as age-related macular degeneration (AMD) or retinitis pigmentosa (RP) result in a permanent loss of the light-sensing photoreceptor cells. The degeneration of photoreceptors leads to vision impairment and, in later stages, complete blindness. Several therapeutic strategies have been developed to slow down or prevent further retinal degeneration, however a definitive cure i.e. replacement of the lost photoreceptors, has not yet been established. Cell-based treatment approaches, by means of photoreceptor t...
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