c-Raf participates in adaptive immune response of Nile tilapia via regulating lymphocyte activation

Publication date: March 2019Source: Fish & Shellfish Immunology, Volume 86Author(s): Xiumei Wei, Tianyu Zhao, Kete Ai, Yu Zhang, Huiying Li, Jialong YangAbstractRAF proto-oncogene serine/threonine-protein kinase (c-Raf) is a MAP kinase kinase kinase (MAPKKK) that participates in the Erk1/2 pathway and plays an important role in lymphocyte activation. However, the study on how c-Raf regulates adaptive immunity in non-mammal is still limited. In present study, based on analysis of sequence characteristics of c-Raf from Oreochromis niloticus (On-c-Raf), we investigated its regulation roles on teleost lymphocyte activation. The On-c-Raf was highly conserved during evolution, which was composed of a Raf-like Ras-binding domain (RBD), a protein kinase C conserved region 1 (C1) domain and a serin...

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