Different frequencies of memory B-cells induced by tetanus, botulinum, and heat-labile toxin binding domains

Publication date: Available online 4 December 2018Source: Microbial PathogenesisAuthor(s): Ehsan Rezaie, Hekmat Nekoie, Ali Miri, Gholamreza Oulad, Ali Ahmadi, Mojtaba Saadati, Mahmood Bozorgmehr, Marzieh Ebrahimi, Jafar SalimianAbstractAlong with robust immunogenicity, an ideal vaccine candidate should be able to produce a long lasting protection. In this regard, the frequency of memory B-cells is possibly an important factor in memory B-cell persistency and duration of immunological memory. On this basis, binding domains of tetanus toxin (HcT), botulinum type A1 toxin (HcA), and heat-labile toxin (LTB) were selected as antigen models that induced long-term, midterm and short-term immune memory, respectively. In the present study, the frequency of total memory B-cells after immunization w...

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