Enhanced central neural gain compensates acoustic trauma-induced cochlear impairment, but unlikely correlates with tinnitus and hyperacusis

Publication date: Available online 29 December 2018Source: NeuroscienceAuthor(s): Dorit Möhrle, Benedikt Hofmeier, Mario Amend, Stephan Wolpert, Kun Ni, Dan Bing, Uwe Klose, Bernd Pichler, Marlies Knipper, Lukas RüttigerAbstractFor successful future therapeutic strategies for tinnitus and hyperacusis, a subcategorization of both conditions on the basis of differentiated neural correlates would be of invaluable advantage. In the present study, we used our refined operant conditioning animal model to divide equally noise-exposed rats into groups with either tinnitus or hyperacusis, with neither condition, or with both conditions co-occurring simultaneously. Using click stimulus and noise burst-evoked Auditory Brainstem Responses (ABR) and Distortion Product Otoacoustic Emissions, no hearin...

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