Photobiological properties of phthalocyanine photosensitizers Photosens, Holosens and Phthalosens: A comparative in vitro analysis

Publication date: Available online 27 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Anna A. Brilkina, Lubov V. Dubasova, Ekaterina A. Sergeeva, Anton J. Pospelov, Natalia Y. Shilyagina, Natalia M. Shakhova, Irina V. BalalaevaAbstractPhotobiological properties of phthalocyanine photosensitizers, namely, clinically approved Photosens and new compounds Holosens and Phthalosens were analyzed on transitional cell carcinoma of the urinary bladder (T24) and human hepatic adenocarcinoma (SK-HEP-1). Photosens is a sulfated aluminum phthalocyanine with the number of sulfo groups 3.4, which is characterized by a high degree of hydrophilicity, slow cellular uptake, localization in lysosomes and the lowest photodynamic activity. Holosens is an octacholine zinc pht...

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