Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121

Publication date: Available online 7 December 2018Source: Journal of Molecular BiologyAuthor(s): Jan-Philipp Scheide-Noeth, Maximilian Rosen, David Baumstark, Harald Dietz, Thomas D. MuellerAbstractInterleukin-5 (IL-5) is a TH2 cytokine involved in many aspects of eosinophil life. Eosinophilic granulocytes play a pathogenic role in the progression of atopic diseases, such as allergy, asthma and atopic dermatitis and hypereosinophilic syndromes. Here, eosinophils upon activation degranulate leading to the release of proinflammatory proteins and mediators stored in intracellular vesicles termed granula thereby causing local inflammation, which when persisting leads to tissue damage and organ failure. As a key regulator of eosinophil function, IL-5 therefore presents a major pharmaceutical ta...

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