Beta-defensins are pro-inflammatory pruritogens that activate Mrgprs

Beta-defensins increase vascular permeability in mouse skin through activation of Mrgprs expressed by mast cells. Defensins also activate Mrgprs expressed by neurons associated with itch, and induce itch themselves, establishing defensins as novel pro-inflammatory pruritogens.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RMon8l