Director's Seminar Series Dr. Goldbach-Mansky will present the work of her Laboratory of Clinical Immunology and Microbiology. Autoinflammatory diseases are a group of rare immune dysregulatory syndromes that present with unexplained fevers, rashes, joint pain, and inflammation in multiple organs, such as the central nervous system, the eyes, inner ears, bones, fat, blood vessels, lungs, and muscles. Many of the disease symptoms present very early in life, and patients do not have infections or malignacies. The discovery of single gene mutations, which modify the regulation of inflammatory pathways that are triggered by exogenous and endogenous " danger " molecules, has provided new concepts to understand this disease group. It also continues to provide us with new targets for intervention...
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