Bitter taste receptors in human monocyte-derived macrophages regulate calcium and nitric oxide signaling to enhance phagocytosis

Bitter taste receptors (T2Rs) are GPCRs expressed in many tissues beyond the tongue. T2Rs in airway ciliated cells participate in innate immunity by detecting bacterial lactones and quinolones to activate antimicrobial nitric oxide (NO) production that also increases mucociliary clearance. T2R polymorphisms correlate with cellular responses in vitro and clinical chronic rhinosinusitis outcomes in vivo. Because macrophages are important players in innate immunity, we investigated if primary human macrophages also express T2Rs and what signaling pathway(s) they activate. (Source: Journal of Allergy and Clinical Immunology)

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