Sex Differences in Type 2 Innate Lymphoid Cells in Adult Asthmatics

Cellular sex differences remain largely unexplored in asthma. Type 2 innate lymphoid cells (ILC2s), identified as critical modulators of asthmatic inflammation, are less abundant in the lungs of HDM-sensitized and challenged male mice. Specifically, lung ILC2s numbers increase in the absence of androgen signaling, but not estrogen. Therefore, we hypothesize that female asthmatics have increased airway ILC2s compared to males.

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