Surfactant Protein D (SP-D) Inhibits Neutrophil Extracellular DNA Trap Formation: Effects of S-nitrosylation

Chronically inflamed airways in asthma and chronic obstructive pulmonary disease (COPD) are susceptible to heightened neutrophilic inflammation but the underlying mechanisms are unclear. We previously showed that SP-D deficiency is associated with increased and prolonged neutrophilic inflammation of the airways in mice. Extracellular release of double stranded DNA by neutrophils contributes to the inflammatory injury. We hypothesized that SP-D interferes with this process.

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