(Source: Journal of Allergy and Clinical Immunology)
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Δευτέρα 17 Δεκεμβρίου 2018
Mast Cell Granules: Modulating adaptive immune response remotely
Mast Cell Granules: Modulating adaptive immune response remotely
(Source: Journal of Allergy and Clinical Immunology)
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Immunotherapeutic Approaches to the Management of Head and Neck Cancer - Cancer Network
Immunotherapeutic Approaches to the Management of Head and Neck Cancer Cancer Network
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Experts discuss the PD-1 checkpoint inhibitors nivolumab and pembrolizumab in the management of head and neck cancer, and how to choose between them.
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Head and Neck Cancer Drugs/Therapeutics Market Set to Encounter Paramount Growth with Myriad Advances - SmarksOn
Market Intelligence Data launched a report, and the title is "Global Head and Neck Cancer Drugs/Therapeutics Market 2018 Insights and Trends". The reputed ...
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Whole Foods Packaging Tests Positive for Cancer-Linked Chemicals - The Strategic Sourceror
Last week, a collection of watchdog groups including Toxic-Free Future and Mind the Store published the results of a study on the packaging offered by five ...
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Deutsche Bank Analysts Give Merck KGaA (FRA:MRK) a €93.00 Price Target - Fairfield Current
Deutsche Bank set a €93.00 ($108.14) target price on Merck KGaA (FRA:MRK) in a report published on Monday, December 10th. The firm currently has a ...
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Pacer Advisors Inc. Purchases New Position in Exelixis, Inc. (EXEL) - Fairfield Current
Pacer Advisors Inc. purchased a new position in shares of Exelixis, Inc. (NASDAQ:EXEL) in the 3rd quarter, according to the company in its most recent 13F filing ...
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Immunotherapeutic Approaches to the Management of Head and Neck Cancer - Cancer Network
Immunotherapeutic Approaches to the Management of Head and Neck Cancer Cancer Network
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Experts discuss the PD-1 checkpoint inhibitors nivolumab and pembrolizumab in the management of head and neck cancer, and how to choose between them.
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Head and Neck Cancer Drugs/Therapeutics Market Set to Encounter Paramount Growth with Myriad Advances - SmarksOn
Market Intelligence Data launched a report, and the title is "Global Head and Neck Cancer Drugs/Therapeutics Market 2018 Insights and Trends". The reputed ...
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Whole Foods Packaging Tests Positive for Cancer-Linked Chemicals - The Strategic Sourceror
Last week, a collection of watchdog groups including Toxic-Free Future and Mind the Store published the results of a study on the packaging offered by five ...
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Deutsche Bank Analysts Give Merck KGaA (FRA:MRK) a €93.00 Price Target - Fairfield Current
Deutsche Bank set a €93.00 ($108.14) target price on Merck KGaA (FRA:MRK) in a report published on Monday, December 10th. The firm currently has a ...
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Pacer Advisors Inc. Purchases New Position in Exelixis, Inc. (EXEL) - Fairfield Current
Pacer Advisors Inc. purchased a new position in shares of Exelixis, Inc. (NASDAQ:EXEL) in the 3rd quarter, according to the company in its most recent 13F filing ...
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Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study
The aim of this study was to explore the characteristics and prognostic information of estrogen receptor-positive/progesterone receptor-negative (ER+/PR−) male breast cancer.
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Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma
The solute carrier (SLC) 7 family genes comprise 14 members and function as cationic amino acid/glycoprotein transporters in many cells, they are essential for the maintenance of amino acid nutrition and survi...
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Magnetic resonance imaging features for differentiating breast papilloma with high-risk or malignant lesions from benign papilloma: a retrospective study on 158 patients
Benign breast papilloma is currently managed with conservative management with close observation. In contrast, papilloma with high-risk or malignant lesions warrants surgical excision. The purpose of our study...
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Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study
The aim of this study was to explore the characteristics and prognostic information of estrogen receptor-positive/progesterone receptor-negative (ER+/PR−) male breast cancer.
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Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma
The solute carrier (SLC) 7 family genes comprise 14 members and function as cationic amino acid/glycoprotein transporters in many cells, they are essential for the maintenance of amino acid nutrition and survi...
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Magnetic resonance imaging features for differentiating breast papilloma with high-risk or malignant lesions from benign papilloma: a retrospective study on 158 patients
Benign breast papilloma is currently managed with conservative management with close observation. In contrast, papilloma with high-risk or malignant lesions warrants surgical excision. The purpose of our study...
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Global Tracheostomy Products Market Major Company Profiles, Regional Landscape and Their Year-Over-Year Growth Rate To 2023 - Blue Bird Magazine
A tracheostomy is a surgically created passageway through the front of the neck and into the trachea (windpipe). A tube is inserted through the hole and enable ...
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Global Cyclin Dependent Kinase 9 Market 2018 (Strategies & Key Players) – Astex Pharmaceuticals Inc, AstraZeneca Plc, Bayer AG, Cyclacel Pharmaceuticals Inc, Eli Lilly and Company, – Daily Industry Updates - Daily Industry Updates
Global Cyclin Dependent Kinase 9 Market 2018 (Strategies & Key Players) – Astex Pharmaceuticals Inc, AstraZeneca Plc, Bayer AG, Cyclacel Pharmaceuticals Inc, Eli Lilly and Company, – Daily Industry Updates Daily Industry Updates
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Global Cyclin Dependent Kinase 9 Market report presents a comprehensive overview of the key drivers influencing market growth, opportunities, the challenges ...
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Global Cyclin Dependent Kinase 9 Market 2018 (Strategies & Key Players) – Astex Pharmaceuticals Inc, AstraZeneca Plc, Bayer AG, Cyclacel Pharmaceuticals Inc, Eli Lilly and Company, – Daily Industry Updates - Daily Industry Updates
Global Cyclin Dependent Kinase 9 Market 2018 (Strategies & Key Players) – Astex Pharmaceuticals Inc, AstraZeneca Plc, Bayer AG, Cyclacel Pharmaceuticals Inc, Eli Lilly and Company, – Daily Industry Updates Daily Industry Updates
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Global Cyclin Dependent Kinase 9 Market report presents a comprehensive overview of the key drivers influencing market growth, opportunities, the challenges ...
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Global Tracheostomy Products Market Major Company Profiles, Regional Landscape and Their Year-Over-Year Growth Rate To 2023 - Blue Bird Magazine
A tracheostomy is a surgically created passageway through the front of the neck and into the trachea (windpipe). A tube is inserted through the hole and enable ...
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Cell Phones Could Be a Source of Flame Retardant Exposure - Medscape
Cell Phones Could Be a Source of Flame Retardant Exposure Medscape
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There is a correlation between the levels of organophosphate esters found on cell phones and their metabolites in urine, say Canadian researchers, although ...
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Mars Hill University graduates 71 - Mountain Xpress
Mars Hill University graduates 71 Mountain Xpress
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"This is only the beginning, not the retirement of learning," Mars Hill University Provost John Omachonu told the university's 71 candidates for graduation. "That's ...
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Cell Phones Could Be a Source of Flame Retardant Exposure - Medscape
Cell Phones Could Be a Source of Flame Retardant Exposure Medscape
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There is a correlation between the levels of organophosphate esters found on cell phones and their metabolites in urine, say Canadian researchers, although ...
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Mars Hill University graduates 71 - Mountain Xpress
Mars Hill University graduates 71 Mountain Xpress
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"This is only the beginning, not the retirement of learning," Mars Hill University Provost John Omachonu told the university's 71 candidates for graduation. "That's ...
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Fat Graft in Composite Breast Augmentation with Round Implant: A New Concept for Breast Reshaping
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A Safer Non-surgical Filler Augmentation Rhinoplasty Based on the Anatomy of the Nose
Abstract
Background
Filler augmentation rhinoplasty is a quick, non-surgical procedure that can produce outcomes comparable to open rhinoplasty surgery. However, the increased frequency of vascular complications has emerged as an important issue. The present study aimed to investigate measures to overcome the vascular complications based on the anatomy of the nose.
Methods
A colored filler was injected into cadavers for augmentation of the nasal dorsum using the retrograde injection technique and direct percutaneous injection technique. The concavity of the sellion area was measured using lateral view cephalography X-ray images. Lastly, we used ultrasonography to determine filler location in 20 Korean patients who had filler injected into the sellion area by injection at the infratip lobule.
Results
Filler was injected into the superficial layer by the retrograde injection technique in three cadavers and into the deep layer by direct percutaneous injection technique in another three cadavers. The average angle between the nasal dorsum skin and sellion was found to be 10.2 ± 2.8 degrees, while the minimum angle was 5.1 degrees. The average distance between the needle tip and nasal bone was 1.9 ± 0.3 mm, while the minimum distance was 0.4 mm.
Conclusions
When performing filler augmentation rhinoplasty on the sellion area, direct percutaneous injection from the glabella can allow more accurate injection into the supraperiosteal level, which can reduce complications such as visual loss and skin necrosis due to vascular compromise.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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Fat Graft in Composite Breast Augmentation with Round Implant: A New Concept for Breast Reshaping
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R26fG7
A Safer Non-surgical Filler Augmentation Rhinoplasty Based on the Anatomy of the Nose
Abstract
Background
Filler augmentation rhinoplasty is a quick, non-surgical procedure that can produce outcomes comparable to open rhinoplasty surgery. However, the increased frequency of vascular complications has emerged as an important issue. The present study aimed to investigate measures to overcome the vascular complications based on the anatomy of the nose.
Methods
A colored filler was injected into cadavers for augmentation of the nasal dorsum using the retrograde injection technique and direct percutaneous injection technique. The concavity of the sellion area was measured using lateral view cephalography X-ray images. Lastly, we used ultrasonography to determine filler location in 20 Korean patients who had filler injected into the sellion area by injection at the infratip lobule.
Results
Filler was injected into the superficial layer by the retrograde injection technique in three cadavers and into the deep layer by direct percutaneous injection technique in another three cadavers. The average angle between the nasal dorsum skin and sellion was found to be 10.2 ± 2.8 degrees, while the minimum angle was 5.1 degrees. The average distance between the needle tip and nasal bone was 1.9 ± 0.3 mm, while the minimum distance was 0.4 mm.
Conclusions
When performing filler augmentation rhinoplasty on the sellion area, direct percutaneous injection from the glabella can allow more accurate injection into the supraperiosteal level, which can reduce complications such as visual loss and skin necrosis due to vascular compromise.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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Iliac crest bone graft donor site analgesia: a new indication for erector spinae plane block
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Re-defining the 3R’s (reduce, refine, and replace) of sustainability to minimize the environmental impact of inhalational anesthetic agents
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In reply: Iliac crest bone graft donor site analgesia: a new indication for erector spinae plane block
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Iliac crest bone graft donor site analgesia: a new indication for erector spinae plane block
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Re-defining the 3R’s (reduce, refine, and replace) of sustainability to minimize the environmental impact of inhalational anesthetic agents
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In reply: Iliac crest bone graft donor site analgesia: a new indication for erector spinae plane block
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Antioxidative status, immunological responses, and heat shock protein expression in hepatopancreas of Chinese mitten crab, Eriocheir sinensis under the exposure of glyphosate
In this study, the antioxidative status and immunological responses of Chinese mitten crab, Eriocheir sinensis, under sublethal exposure of glyphosate were investigated by detecting the antioxidative and immune-related enzyme activity, acetylcholinesterase (AChE) activity and relative mRNA expression of heat shock proteins (HSPs) in hepatopancreas. The results showed that high concentrations of glyphosate (44 and 98 mg/L) could induce significant alteration of superoxide dismutase (SOD), peroxidase (POD), acid phosphatase (ACP), alkaline phosphatase (AKP), and phenoloxidase (PO) activities by first rising then falling during the exposure. However, AChE activity in all treatments including 4.4 mg/L was inhibited markedly after 6 h of exposure. In addition, the relative mRNA expression...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Contrasting Response Genetics (RGDXQ) & Vermillion (VRML) - Fairfield Current
Response Genetics (OTCMKTS:RGDXQ) and Vermillion (NASDAQ:VRML) are both small-cap medical companies, but which is the better business? We will ...
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Antioxidative status, immunological responses, and heat shock protein expression in hepatopancreas of Chinese mitten crab, Eriocheir sinensis under the exposure of glyphosate
In this study, the antioxidative status and immunological responses of Chinese mitten crab, Eriocheir sinensis, under sublethal exposure of glyphosate were investigated by detecting the antioxidative and immune-related enzyme activity, acetylcholinesterase (AChE) activity and relative mRNA expression of heat shock proteins (HSPs) in hepatopancreas. The results showed that high concentrations of glyphosate (44 and 98 mg/L) could induce significant alteration of superoxide dismutase (SOD), peroxidase (POD), acid phosphatase (ACP), alkaline phosphatase (AKP), and phenoloxidase (PO) activities by first rising then falling during the exposure. However, AChE activity in all treatments including 4.4 mg/L was inhibited markedly after 6 h of exposure. In addition, the relative mRNA expression...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Contrasting Response Genetics (RGDXQ) & Vermillion (VRML) - Fairfield Current
Response Genetics (OTCMKTS:RGDXQ) and Vermillion (NASDAQ:VRML) are both small-cap medical companies, but which is the better business? We will ...
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Johnson & Johnson Knew About Asbestos in Baby Powder for Decades, Reuters Investigation Finds - EcoWatch
Johnson & Johnson Knew About Asbestos in Baby Powder for Decades, Reuters Investigation Finds EcoWatch
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A Reuters investigation charges that Johnson & Johnson, a multi-billion dollar company known for its healthcare products, knew for decades that its iconic ...
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Asbestos in Baby Powder: What Is It and Why Should You Worry? - Yahoo India News
Should you use baby powder on your infant? Find out.
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Johnson & Johnson Knew About Asbestos in Baby Powder for Decades, Reuters Investigation Finds - EcoWatch
Johnson & Johnson Knew About Asbestos in Baby Powder for Decades, Reuters Investigation Finds EcoWatch
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A Reuters investigation charges that Johnson & Johnson, a multi-billion dollar company known for its healthcare products, knew for decades that its iconic ...
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Asbestos in Baby Powder: What Is It and Why Should You Worry? - Yahoo India News
Should you use baby powder on your infant? Find out.
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Fat Graft in Composite Breast Augmentation with Round Implant: A New Concept for Breast Reshaping
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R26fG7
A Safer Non-surgical Filler Augmentation Rhinoplasty Based on the Anatomy of the Nose
Abstract
Background
Filler augmentation rhinoplasty is a quick, non-surgical procedure that can produce outcomes comparable to open rhinoplasty surgery. However, the increased frequency of vascular complications has emerged as an important issue. The present study aimed to investigate measures to overcome the vascular complications based on the anatomy of the nose.
Methods
A colored filler was injected into cadavers for augmentation of the nasal dorsum using the retrograde injection technique and direct percutaneous injection technique. The concavity of the sellion area was measured using lateral view cephalography X-ray images. Lastly, we used ultrasonography to determine filler location in 20 Korean patients who had filler injected into the sellion area by injection at the infratip lobule.
Results
Filler was injected into the superficial layer by the retrograde injection technique in three cadavers and into the deep layer by direct percutaneous injection technique in another three cadavers. The average angle between the nasal dorsum skin and sellion was found to be 10.2 ± 2.8 degrees, while the minimum angle was 5.1 degrees. The average distance between the needle tip and nasal bone was 1.9 ± 0.3 mm, while the minimum distance was 0.4 mm.
Conclusions
When performing filler augmentation rhinoplasty on the sellion area, direct percutaneous injection from the glabella can allow more accurate injection into the supraperiosteal level, which can reduce complications such as visual loss and skin necrosis due to vascular compromise.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ULi0Qe
Fat Graft in Composite Breast Augmentation with Round Implant: A New Concept for Breast Reshaping
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R26fG7
A Safer Non-surgical Filler Augmentation Rhinoplasty Based on the Anatomy of the Nose
Abstract
Background
Filler augmentation rhinoplasty is a quick, non-surgical procedure that can produce outcomes comparable to open rhinoplasty surgery. However, the increased frequency of vascular complications has emerged as an important issue. The present study aimed to investigate measures to overcome the vascular complications based on the anatomy of the nose.
Methods
A colored filler was injected into cadavers for augmentation of the nasal dorsum using the retrograde injection technique and direct percutaneous injection technique. The concavity of the sellion area was measured using lateral view cephalography X-ray images. Lastly, we used ultrasonography to determine filler location in 20 Korean patients who had filler injected into the sellion area by injection at the infratip lobule.
Results
Filler was injected into the superficial layer by the retrograde injection technique in three cadavers and into the deep layer by direct percutaneous injection technique in another three cadavers. The average angle between the nasal dorsum skin and sellion was found to be 10.2 ± 2.8 degrees, while the minimum angle was 5.1 degrees. The average distance between the needle tip and nasal bone was 1.9 ± 0.3 mm, while the minimum distance was 0.4 mm.
Conclusions
When performing filler augmentation rhinoplasty on the sellion area, direct percutaneous injection from the glabella can allow more accurate injection into the supraperiosteal level, which can reduce complications such as visual loss and skin necrosis due to vascular compromise.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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Head and Neck Cancer Drugs/Therapeutics Market Set to Encounter Paramount Growth with Myriad Advances - SmarksOn
Market Intelligence Data launched a report, and the title is "Global Head and Neck Cancer Drugs/Therapeutics Market 2018 Insights and Trends". The reputed ...
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Head and Neck Cancer Drugs/Therapeutics Market Set to Encounter Paramount Growth with Myriad Advances - SmarksOn
Market Intelligence Data launched a report, and the title is "Global Head and Neck Cancer Drugs/Therapeutics Market 2018 Insights and Trends". The reputed ...
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Everyday Hero: Dire Diagnosis Opens Dollhouse Man's Heart - News 13 Orlando
Everyday Hero: Dire Diagnosis Opens Dollhouse Man's Heart News 13 Orlando
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Paul Heuer now lives his best life because of his worst day.
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Radioactive Iodine Ablation Therapy Market to Witness Comprehensive Growth by 2028 - Daily Industry Updates
Radioactive Iodine Ablation Therapy Market to Witness Comprehensive Growth by 2028 Daily Industry Updates
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Radioactive iodine ablation therapy also known as radioiodine remnant ablation which improves survival rate of patients which affected by papillary or follicular ...
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Missouri man transforms his life from jail to ultramarathons - Kansas City Star
Missouri man transforms his life from jail to ultramarathons Kansas City Star
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From the penitentiary to ultramarathons: Missouri saves his life by running.
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Everyday Hero: Dire Diagnosis Opens Dollhouse Man's Heart - News 13 Orlando
Everyday Hero: Dire Diagnosis Opens Dollhouse Man's Heart News 13 Orlando
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Paul Heuer now lives his best life because of his worst day.
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Radioactive Iodine Ablation Therapy Market to Witness Comprehensive Growth by 2028 - Daily Industry Updates
Radioactive Iodine Ablation Therapy Market to Witness Comprehensive Growth by 2028 Daily Industry Updates
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Radioactive iodine ablation therapy also known as radioiodine remnant ablation which improves survival rate of patients which affected by papillary or follicular ...
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Missouri man transforms his life from jail to ultramarathons - Kansas City Star
Missouri man transforms his life from jail to ultramarathons Kansas City Star
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From the penitentiary to ultramarathons: Missouri saves his life by running.
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IJERPH, Vol. 15, Pages 2887: Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology
This study aimed to confirm the association between sinonasal malignant tumors and patients' occupations with consideration for sinonasal inverted papillomas (SNIPs) as a control group. Thirty-two patients affected by adenocarcinoma (ADC) and 21 non-adenocarcinoma epithelial tumors (NAETs) were compared to 65 patients diagnosed with SNIPs. All patients were recruited in the same clinical setting between 2004 and 2016. A questionnaire was used to collect information on non-occupational factors (age, sex, smoking, allergies, and chronic sinusitis) and occupations (wood- and leather-related occupations, textile industry, metal working). Odds ratios (OR) with 95% confidence intervals (CI) associated with selected occupations were obtained by a multinomial and exact logistic regre...
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Allergy inhibitory receptor ‐1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages
ConclusionAllergin ‐1 might play an inhibitory role in autoantibody production via upregulation of macrophage phagocytosis. (Source: International Journal of Rheumatic Diseases)
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IJERPH, Vol. 15, Pages 2887: Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology
This study aimed to confirm the association between sinonasal malignant tumors and patients' occupations with consideration for sinonasal inverted papillomas (SNIPs) as a control group. Thirty-two patients affected by adenocarcinoma (ADC) and 21 non-adenocarcinoma epithelial tumors (NAETs) were compared to 65 patients diagnosed with SNIPs. All patients were recruited in the same clinical setting between 2004 and 2016. A questionnaire was used to collect information on non-occupational factors (age, sex, smoking, allergies, and chronic sinusitis) and occupations (wood- and leather-related occupations, textile industry, metal working). Odds ratios (OR) with 95% confidence intervals (CI) associated with selected occupations were obtained by a multinomial and exact logistic regre...
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Allergy inhibitory receptor ‐1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages
ConclusionAllergin ‐1 might play an inhibitory role in autoantibody production via upregulation of macrophage phagocytosis. (Source: International Journal of Rheumatic Diseases)
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High iodine distribution, low intake among children after Fukushima nuclear accident - Healio
High iodine distribution, low intake among children after Fukushima nuclear accident Healio
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Despite a high distribution rate of stable iodine after the 2011 Fukushima nuclear accident in Japan, only 63.5% of parents reported children took the tablets, ...
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High iodine distribution, low intake among children after Fukushima nuclear accident - Healio
High iodine distribution, low intake among children after Fukushima nuclear accident Healio
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Despite a high distribution rate of stable iodine after the 2011 Fukushima nuclear accident in Japan, only 63.5% of parents reported children took the tablets, ...
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Role of pretreatment 18F-FDG PET/CT parameters in predicting outcome of non-endemic EBV DNA-related nasopharyngeal cancer (NPC) patients treated with IMRT and chemotherapy
Abstract
Purpose
To evaluate the prognostic role of pretreatment 18F-FDG PET/CT metabolic parameters in non-endemic Epstein–Barr Virus (EBV DNA)-related nasopharyngeal cancer (NPC) patients treated with curative intensity-modulated radiation therapy (IMRT) with or without chemotherapy (CHT).
Materials/methods
We retrospectively reviewed clinical data of 160 consecutive non-metastatic NPC patients who received IMRT with or without CHT. Forty-nine out of 160 patients that underwent whole body 18F-FDG PET/CT at our institution for disease staging with a minimum follow-up to 12 months were included in this study. We evaluated the relationship between maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume and total lesion glycolysis (TLG) of primary tumor and cervical lymph nodes with disease-free survival (DFS) and overall survival (OS). We also investigated the prognostic role of clinical variables such as age, disease stage, plasma EBV DNA load (copies/ml), gross tumor volume of primary tumor and lymph nodes.
Results
Median follow-up was 55 months. Two- and 5-year OS were 95.8% and 90.5%, respectively, while DFS was 83.4% at both time points. SUVmax of primary tumor ≥ 18.8 g/ml and primary tumor TLG ≥ 203.1 g were significant prognostic factors of worse OS. Furthermore, stages IVB and EBV DNA load ≥ 3493 copies/ml were significantly associated with lower DFS. No correlation was found between PET parameters and plasma EBV DNA load.
Conclusion
Even in a limited series, our data suggested that SUVmax, SUVmean and TLG of primary tumor could predict a poor outcome in NPC patients also in non-endemic area hypothesizing their use for refinement of prognostication.
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Dynamic contrast-enhanced magnetic resonance imaging in locally advanced rectal cancer: role of perfusion parameters in the assessment of response to treatment
Abstract
Purpose
To correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to tumor grading and to assess their reliability in predicting pathological complete response (pCR) before neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC).
Materials and methods
Forty patients (24 male; mean age, 67.3 ± 8.1 years) with histologically proven LARC who had undergone 3-Tesla DCE-MRI before (MRI_1) and after CRT (MRI_2) between August 2015 and February 2016 were included in this retrospective study. DCE-MRI parameters at MRI_1 and MRI_2 were extracted by two board certified radiologists in consensus reading with Olea Sphere 2.3 software using the extended Tofts model. Based on DCE-MRI results, patients were divided in complete responders (CR) and non-complete responders (nCR) and the perfusion parameters were correlated to tumor grading and pCR.
Results
Wash-out and Kep at MRI_1 showed significant correlation with LARC grading (P = 0.004 and 0.01, respectively). Ve showed a significant increase between MRI_1 (0.47 ± 0.27) and MRI_2 (0.63 ± 0.23; P = 0.007). Ktrans measured at MRI_1 was significantly higher in CR (0.66 ± 0.48) compared to nCR (0.53 ± 0.34, P = 0.02).
Conclusion
Wash-out and Kep measured before CRT correlate with LARC grading. Ve changes during CRT, while Ktrans measured before CRT may predict the response to therapy. Therefore, DCE-MRI parameters can predict tumor aggressiveness and CRT efficacy, playing a role as imaging biomarkers in patients with LARC.
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Role of pretreatment 18F-FDG PET/CT parameters in predicting outcome of non-endemic EBV DNA-related nasopharyngeal cancer (NPC) patients treated with IMRT and chemotherapy
Abstract
Purpose
To evaluate the prognostic role of pretreatment 18F-FDG PET/CT metabolic parameters in non-endemic Epstein–Barr Virus (EBV DNA)-related nasopharyngeal cancer (NPC) patients treated with curative intensity-modulated radiation therapy (IMRT) with or without chemotherapy (CHT).
Materials/methods
We retrospectively reviewed clinical data of 160 consecutive non-metastatic NPC patients who received IMRT with or without CHT. Forty-nine out of 160 patients that underwent whole body 18F-FDG PET/CT at our institution for disease staging with a minimum follow-up to 12 months were included in this study. We evaluated the relationship between maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume and total lesion glycolysis (TLG) of primary tumor and cervical lymph nodes with disease-free survival (DFS) and overall survival (OS). We also investigated the prognostic role of clinical variables such as age, disease stage, plasma EBV DNA load (copies/ml), gross tumor volume of primary tumor and lymph nodes.
Results
Median follow-up was 55 months. Two- and 5-year OS were 95.8% and 90.5%, respectively, while DFS was 83.4% at both time points. SUVmax of primary tumor ≥ 18.8 g/ml and primary tumor TLG ≥ 203.1 g were significant prognostic factors of worse OS. Furthermore, stages IVB and EBV DNA load ≥ 3493 copies/ml were significantly associated with lower DFS. No correlation was found between PET parameters and plasma EBV DNA load.
Conclusion
Even in a limited series, our data suggested that SUVmax, SUVmean and TLG of primary tumor could predict a poor outcome in NPC patients also in non-endemic area hypothesizing their use for refinement of prognostication.
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Dynamic contrast-enhanced magnetic resonance imaging in locally advanced rectal cancer: role of perfusion parameters in the assessment of response to treatment
Abstract
Purpose
To correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to tumor grading and to assess their reliability in predicting pathological complete response (pCR) before neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC).
Materials and methods
Forty patients (24 male; mean age, 67.3 ± 8.1 years) with histologically proven LARC who had undergone 3-Tesla DCE-MRI before (MRI_1) and after CRT (MRI_2) between August 2015 and February 2016 were included in this retrospective study. DCE-MRI parameters at MRI_1 and MRI_2 were extracted by two board certified radiologists in consensus reading with Olea Sphere 2.3 software using the extended Tofts model. Based on DCE-MRI results, patients were divided in complete responders (CR) and non-complete responders (nCR) and the perfusion parameters were correlated to tumor grading and pCR.
Results
Wash-out and Kep at MRI_1 showed significant correlation with LARC grading (P = 0.004 and 0.01, respectively). Ve showed a significant increase between MRI_1 (0.47 ± 0.27) and MRI_2 (0.63 ± 0.23; P = 0.007). Ktrans measured at MRI_1 was significantly higher in CR (0.66 ± 0.48) compared to nCR (0.53 ± 0.34, P = 0.02).
Conclusion
Wash-out and Kep measured before CRT correlate with LARC grading. Ve changes during CRT, while Ktrans measured before CRT may predict the response to therapy. Therefore, DCE-MRI parameters can predict tumor aggressiveness and CRT efficacy, playing a role as imaging biomarkers in patients with LARC.
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Survivors and Caregivers Discuss Food Anxiety After Cancer - Curetoday.com
Survivors and Caregivers Discuss Food Anxiety After Cancer Curetoday.com
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A person's relationship with food can change after a cancer diagnosis, stirring up feelings of anxiety. A recent seminar discussed strategies that can help.
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Survivors and Caregivers Discuss Food Anxiety After Cancer - Curetoday.com
Survivors and Caregivers Discuss Food Anxiety After Cancer Curetoday.com
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A person's relationship with food can change after a cancer diagnosis, stirring up feelings of anxiety. A recent seminar discussed strategies that can help.
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European Commission Approves Merck's KEYTRUDA® (pembrolizumab) as Adjuvant Therapy for Adults with Resected Stage III Melanoma - Business Wire
European Commission Approves Merck's KEYTRUDA® (pembrolizumab) as Adjuvant Therapy for Adults with Resected Stage III Melanoma Business Wire
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KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the European ...
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European Commission Approves Merck's KEYTRUDA® (pembrolizumab) as Adjuvant Therapy for Adults with Resected Stage III Melanoma - Business Wire
European Commission Approves Merck's KEYTRUDA® (pembrolizumab) as Adjuvant Therapy for Adults with Resected Stage III Melanoma Business Wire
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KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the European ...
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Development of an algorithm to automatically compress a CT image to visually lossless threshold
Abstract
Background
To develop an algorithm to predict the visually lossless thresholds (VLTs) of CT images solely using the original images by exploiting the image features and DICOM header information for JPEG2000 compression and to evaluate the algorithm in comparison with pre-existing image fidelity metrics.
Methods
Five radiologists independently determined the VLT for 206 body CT images for JPEG2000 compression using QUEST procedure. The images were divided into training (n = 103) and testing (n = 103) sets. Using the training set, a multiple linear regression (MLR) model was constructed regarding the image features and DICOM header information as independent variables and regarding the VLTs determined with median value of the radiologists' responses (VLTrad) as dependent variable, after determining an optimal subset of independent variables by backward stepwise selection in a cross-validation scheme.
The performance was evaluated on the testing set by measuring absolute differences and intra-class correlation (ICC) coefficient between the VLTrad and the VLTs predicted by the model (VLTmodel). The performance of the model was also compared two metrics, peak signal-to-noise ratio (PSNR) and high-dynamic range visual difference predictor (HDRVDP). The time for computing VLTs between MLR model, PSNR, and HDRVDP were compared using the repeated ANOVA with a post-hoc analysis. P < 0.05 was considered to indicate a statistically significant difference.
Results
The means of absolute differences with the VLTrad were 0.58 (95% CI, 0.48, 0.67), 0.73 (0.61, 0.85), and 0.68 (0.58, 0.79), for the MLR model, PSNR, and HDRVDP, respectively, showing significant difference between them (p < 0.01). The ICC coefficients of MLR model, PSNR, and HDRVDP were 0.88 (95% CI, 0.81, 0.95), 0.85 (0.79, 0.91), and 0.84 (0.77, 0.91). The computing times for calculating VLT per image were 1.5 ± 0.1 s, 3.9 ± 0.3 s, and 68.2 ± 1.4 s, for MLR metric, PSNR, and HDRVDP, respectively.
Conclusions
The proposed MLR model directly predicting the VLT of a given CT image showed competitive performance to those of image fidelity metrics with less computational expenses. The model would be promising to be used for adaptive compression of CT images.
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Guidelines to the Practice of Anesthesia – Revised Edition 2019
Overview
The Guidelines to the Practice of Anesthesia Revised Edition 2019 (the Guidelines) were prepared by the Canadian Anesthesiologists' Society (CAS), which reserves the right to determine their publication and distribution. The Guidelines are subject to revision and updated versions are published annually. The Guidelines to the Practice of Anesthesia Revised Edition 2019 supersedes all previously published versions of this document. Although the CAS encourages Canadian anesthesiologists to adhere to its practice guidelines to ensure high-quality patient care, the CAS cannot guarantee any specific patient outcome. Anesthesiologists should exercise their own professional judgement in determining the proper course of action for any patient's circumstances. The CAS assumes no responsibility or liability for any error or omission arising from the use of any information contained in its Guidelines to the Practice of Anesthesia.
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Development of an algorithm to automatically compress a CT image to visually lossless threshold
Abstract
Background
To develop an algorithm to predict the visually lossless thresholds (VLTs) of CT images solely using the original images by exploiting the image features and DICOM header information for JPEG2000 compression and to evaluate the algorithm in comparison with pre-existing image fidelity metrics.
Methods
Five radiologists independently determined the VLT for 206 body CT images for JPEG2000 compression using QUEST procedure. The images were divided into training (n = 103) and testing (n = 103) sets. Using the training set, a multiple linear regression (MLR) model was constructed regarding the image features and DICOM header information as independent variables and regarding the VLTs determined with median value of the radiologists' responses (VLTrad) as dependent variable, after determining an optimal subset of independent variables by backward stepwise selection in a cross-validation scheme.
The performance was evaluated on the testing set by measuring absolute differences and intra-class correlation (ICC) coefficient between the VLTrad and the VLTs predicted by the model (VLTmodel). The performance of the model was also compared two metrics, peak signal-to-noise ratio (PSNR) and high-dynamic range visual difference predictor (HDRVDP). The time for computing VLTs between MLR model, PSNR, and HDRVDP were compared using the repeated ANOVA with a post-hoc analysis. P < 0.05 was considered to indicate a statistically significant difference.
Results
The means of absolute differences with the VLTrad were 0.58 (95% CI, 0.48, 0.67), 0.73 (0.61, 0.85), and 0.68 (0.58, 0.79), for the MLR model, PSNR, and HDRVDP, respectively, showing significant difference between them (p < 0.01). The ICC coefficients of MLR model, PSNR, and HDRVDP were 0.88 (95% CI, 0.81, 0.95), 0.85 (0.79, 0.91), and 0.84 (0.77, 0.91). The computing times for calculating VLT per image were 1.5 ± 0.1 s, 3.9 ± 0.3 s, and 68.2 ± 1.4 s, for MLR metric, PSNR, and HDRVDP, respectively.
Conclusions
The proposed MLR model directly predicting the VLT of a given CT image showed competitive performance to those of image fidelity metrics with less computational expenses. The model would be promising to be used for adaptive compression of CT images.
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Guidelines to the Practice of Anesthesia – Revised Edition 2019
Overview
The Guidelines to the Practice of Anesthesia Revised Edition 2019 (the Guidelines) were prepared by the Canadian Anesthesiologists' Society (CAS), which reserves the right to determine their publication and distribution. The Guidelines are subject to revision and updated versions are published annually. The Guidelines to the Practice of Anesthesia Revised Edition 2019 supersedes all previously published versions of this document. Although the CAS encourages Canadian anesthesiologists to adhere to its practice guidelines to ensure high-quality patient care, the CAS cannot guarantee any specific patient outcome. Anesthesiologists should exercise their own professional judgement in determining the proper course of action for any patient's circumstances. The CAS assumes no responsibility or liability for any error or omission arising from the use of any information contained in its Guidelines to the Practice of Anesthesia.
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Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemic Mastocytosis
Condition: Indolent Systemic Mastocytosis Interventions: Other: Placebo; Biological: Sarilumab Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Non-interventional Research Clinical Research Program for Establishment of Milk Protein Allergy Oral Immune Tolerance
Condition: Milk Protein Allergy Intervention: Sponsor: Peking University Third Hospital Active, not recruiting (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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MAPS & ITEC Cohorts: 6-8 Years Follow-up
Conditions: Immunotherapy; Allergy and Immunology; Asthma Interventions: Drug: House dust-mite SLIT; Drug: Normal saline Sponsors: University of Southampton; Isle of Wight NHS Trust Recruiting (Source: ClinicalTrials.gov)
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miR-29a-3p inhibits growth, proliferation, and invasion of papillary t | CMAR - Dove Medical Press
miR-29a-3p inhibits growth, proliferation, and invasion of papillary thyroid carcinoma by suppressing NF-kappaB signaling via direct targeting of OTUB2 Yanfei ...
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Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemic Mastocytosis
Condition: Indolent Systemic Mastocytosis Interventions: Other: Placebo; Biological: Sarilumab Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Non-interventional Research Clinical Research Program for Establishment of Milk Protein Allergy Oral Immune Tolerance
Condition: Milk Protein Allergy Intervention: Sponsor: Peking University Third Hospital Active, not recruiting (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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MAPS & ITEC Cohorts: 6-8 Years Follow-up
Conditions: Immunotherapy; Allergy and Immunology; Asthma Interventions: Drug: House dust-mite SLIT; Drug: Normal saline Sponsors: University of Southampton; Isle of Wight NHS Trust Recruiting (Source: ClinicalTrials.gov)
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miR-29a-3p inhibits growth, proliferation, and invasion of papillary t | CMAR - Dove Medical Press
miR-29a-3p inhibits growth, proliferation, and invasion of papillary thyroid carcinoma by suppressing NF-kappaB signaling via direct targeting of OTUB2 Yanfei ...
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Support Groups: Dec. 16, 2018 | Health | tribstar.com - Terre Haute Tribune Star
Support Groups: Dec. 16, 2018 | Health | tribstar.com Terre Haute Tribune Star
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For more information and/or sites, contact the numbers listed.
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Support Groups: Dec. 16, 2018 | Health | tribstar.com - Terre Haute Tribune Star
Support Groups: Dec. 16, 2018 | Health | tribstar.com Terre Haute Tribune Star
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For more information and/or sites, contact the numbers listed.
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The prognostic impact of pathologic lymph nodes in HPV-positive oropharyngeal cancers
Publication date: February 2019
Source: Oral Oncology, Volume 89
Author(s): Margueritta El Asmar, Hua-Ling Tsai, Carole Fakhry, Christopher A. Maroun, Rajarsi Mandal, Drew M. Pardoll, Hao Wang
Abstract
Purpose
Recent pathologic staging of HPV-positive oropharyngeal squamous cell carcinomas (OPSCC) is solely dependent on number of pathologic nodes. Using a large dataset, we aimed to understand how increase in pathologic lymph nodes (LN) associated with overall survival.
Materials and methods
National Cancer Database was queried for HPV-positive OPSCC patients undergoing primary surgery with LN dissection between 2010 and 2013. Kaplan-Meier, univariate and multivariate Cox models were used to evaluate overall survival. Interaction between nodal status and radiotherapy was examined.
Results
Implications of pathologic LN on overall survival differed according to receipt of post-operative radiotherapy (p-valueinteraction = 0.008). In patients who did not receive adjuvant radiotherapy, there were no significant differences in risk of death from 0 to 2 pathologic nodes (adjusted HR (aHR) 0.92, 95%CI 0.61–1.4). However, risk increased by 18% on average with each additional LN thereafter (aHR 1.18, 95%CI 1.1–1.27). Among radiotherapy patients, after adjusting for other variables, patients with 1 pathologic LN had 70% lower risk of death than those with 0 pathologic LN (aHR 0.30, 95%CI 0.14–0.64). Thereafter, risk increased on average by 7% with each additional LN (aHR 1.07, 95%CI 1–1.14).
Conclusion
The prognostic impact of pathologic nodes in resected HPV-positive OPSCC differs by receipt of radiotherapy, with better outcomes in post-operative radiotherapy treated patients with one pathologic LN than none. These findings suggest that LN involvement may improve anti-tumor immune responses following radiotherapy, or result in earlier detection and treatment of disease. These results merit further studies to corroborate these findings and establish the underlying mechanism.
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The prognostic impact of pathologic lymph nodes in HPV-positive oropharyngeal cancers
Publication date: February 2019
Source: Oral Oncology, Volume 89
Author(s): Margueritta El Asmar, Hua-Ling Tsai, Carole Fakhry, Christopher A. Maroun, Rajarsi Mandal, Drew M. Pardoll, Hao Wang
Abstract
Purpose
Recent pathologic staging of HPV-positive oropharyngeal squamous cell carcinomas (OPSCC) is solely dependent on number of pathologic nodes. Using a large dataset, we aimed to understand how increase in pathologic lymph nodes (LN) associated with overall survival.
Materials and methods
National Cancer Database was queried for HPV-positive OPSCC patients undergoing primary surgery with LN dissection between 2010 and 2013. Kaplan-Meier, univariate and multivariate Cox models were used to evaluate overall survival. Interaction between nodal status and radiotherapy was examined.
Results
Implications of pathologic LN on overall survival differed according to receipt of post-operative radiotherapy (p-valueinteraction = 0.008). In patients who did not receive adjuvant radiotherapy, there were no significant differences in risk of death from 0 to 2 pathologic nodes (adjusted HR (aHR) 0.92, 95%CI 0.61–1.4). However, risk increased by 18% on average with each additional LN thereafter (aHR 1.18, 95%CI 1.1–1.27). Among radiotherapy patients, after adjusting for other variables, patients with 1 pathologic LN had 70% lower risk of death than those with 0 pathologic LN (aHR 0.30, 95%CI 0.14–0.64). Thereafter, risk increased on average by 7% with each additional LN (aHR 1.07, 95%CI 1–1.14).
Conclusion
The prognostic impact of pathologic nodes in resected HPV-positive OPSCC differs by receipt of radiotherapy, with better outcomes in post-operative radiotherapy treated patients with one pathologic LN than none. These findings suggest that LN involvement may improve anti-tumor immune responses following radiotherapy, or result in earlier detection and treatment of disease. These results merit further studies to corroborate these findings and establish the underlying mechanism.
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Overcoming metallic artefacts from orthopaedic wrist volar plating on a low-field MRI scanner
Abstract
Purpose
To quantitatively compare the artefact reduction between standard and metallic artefact reduction (MAR) fast spin echo (FSE) T2 sequences in a low-field magnetic resonance imaging (MRI) scanner (0.3 T) in patients with titanium volar wrist plating.
Materials and methods
Sixteen patients with fractures of the distal radius, treated with titanium volar wrist plating and screws, were examined using a dedicated 0.3 T MRI scanner. Coronal standard FSE T2, FSE T2 high bandwidth (HiBW) and FSE T2 view angle tilting (VAT) sequences were performed. Metallic artefact volume, consisting of both "black" and "bright" artefacts, was calculated for each sequence. Quantitative differences were compared using repeated measures ANOVA test (P < 0.05).
Results
FSE T2 HiBW and FSE T2 VAT showed a significant reduction in artefact volume compared to the standard sequence. Differences between the artefact volume of the standard FSE T2, HiBW and VAT sequences were statistically significant for both the "black" and "bright" artefacts (P < 0.0001). Differences between the 1.5 HiBW and VAT sequences were statistically significant (black P < 0.0001, bright P < 0.0302).
Conclusions
MAR sequences significantly reduced metallic artefacts in vivo using a 0.3 T MRI scanner.
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Overcoming metallic artefacts from orthopaedic wrist volar plating on a low-field MRI scanner
Abstract
Purpose
To quantitatively compare the artefact reduction between standard and metallic artefact reduction (MAR) fast spin echo (FSE) T2 sequences in a low-field magnetic resonance imaging (MRI) scanner (0.3 T) in patients with titanium volar wrist plating.
Materials and methods
Sixteen patients with fractures of the distal radius, treated with titanium volar wrist plating and screws, were examined using a dedicated 0.3 T MRI scanner. Coronal standard FSE T2, FSE T2 high bandwidth (HiBW) and FSE T2 view angle tilting (VAT) sequences were performed. Metallic artefact volume, consisting of both "black" and "bright" artefacts, was calculated for each sequence. Quantitative differences were compared using repeated measures ANOVA test (P < 0.05).
Results
FSE T2 HiBW and FSE T2 VAT showed a significant reduction in artefact volume compared to the standard sequence. Differences between the artefact volume of the standard FSE T2, HiBW and VAT sequences were statistically significant for both the "black" and "bright" artefacts (P < 0.0001). Differences between the 1.5 HiBW and VAT sequences were statistically significant (black P < 0.0001, bright P < 0.0302).
Conclusions
MAR sequences significantly reduced metallic artefacts in vivo using a 0.3 T MRI scanner.
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Global Head and Neck Cancer Market Analysis Showcases Growth Trends and Opportunity Forecasted Until 2026 - Journal of Industry
Global Head and Neck Cancer Market Analysis Showcases Growth Trends and Opportunity Forecasted Until 2026 Journal of Industry
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The expanding database of Market Research Reports Search Engine (MRRSE) has been recently updated by the addition of a new study which is titled as ...
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Global Head and Neck Cancer Market Analysis Showcases Growth Trends and Opportunity Forecasted Until 2026 - Journal of Industry
Global Head and Neck Cancer Market Analysis Showcases Growth Trends and Opportunity Forecasted Until 2026 Journal of Industry
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The expanding database of Market Research Reports Search Engine (MRRSE) has been recently updated by the addition of a new study which is titled as ...
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Bringing benign ectomesenchymal odontogenic tumours to the lab: an in vitro study using an organotypic culture model
Abstract
Background
Benign neoplasms exhibit most of the cellular phenomena considered hallmarks of cancer, except the capacity to metastasize. Thus, the elucidation of the mechanisms associated with the progression of benign neoplasms may complement and clarify the mechanisms involved in carcinogenesis. Benign odontogenic tumours often result in facial deformities and morbidities, and have complex pathogenesis, mainly due to the diversity of interactions between the odontogenic epithelium and the ectomesenchyme. Primary cell culture of such tumours is not only difficult to be established and maintained, but also tumour cells lose characteristic cellular morphology. Considering gene expression, growth, migration, proliferation and cellular morphology are controlled by cell‐cell interactions and cell‐extracellular matrix interactions, cell culture in 3D substrates has gained space as a way to overcome some of the limitations of traditional monolayer cell culture systems.
Methods
In this study, fragments obtained from mesenchymal odontogenic tumours were cultured in collagen type I scaffolds. Invasion tests were performed in these models, as well as phenotypic characterization of the cultured tumours.
Results
The results obtained for the odontogenic myxoma and the cemento‐ossifying fibroma demonstrate a good reproduction of the growth pattern of these tumours under ex vivo conditions. Microscopic evaluation showed maintenance of cell viability in the explants for more than 30 days, without the presence of necrosis.
Conclusion
This is the first study involving long‐term 3D primary cultures of benign odontogenic tumours, which is expected to support complex approaches to cell and molecular biology, and serve as an experimental model for testing molecular therapies.
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Bringing benign ectomesenchymal odontogenic tumours to the lab: an in vitro study using an organotypic culture model
Abstract
Background
Benign neoplasms exhibit most of the cellular phenomena considered hallmarks of cancer, except the capacity to metastasize. Thus, the elucidation of the mechanisms associated with the progression of benign neoplasms may complement and clarify the mechanisms involved in carcinogenesis. Benign odontogenic tumours often result in facial deformities and morbidities, and have complex pathogenesis, mainly due to the diversity of interactions between the odontogenic epithelium and the ectomesenchyme. Primary cell culture of such tumours is not only difficult to be established and maintained, but also tumour cells lose characteristic cellular morphology. Considering gene expression, growth, migration, proliferation and cellular morphology are controlled by cell‐cell interactions and cell‐extracellular matrix interactions, cell culture in 3D substrates has gained space as a way to overcome some of the limitations of traditional monolayer cell culture systems.
Methods
In this study, fragments obtained from mesenchymal odontogenic tumours were cultured in collagen type I scaffolds. Invasion tests were performed in these models, as well as phenotypic characterization of the cultured tumours.
Results
The results obtained for the odontogenic myxoma and the cemento‐ossifying fibroma demonstrate a good reproduction of the growth pattern of these tumours under ex vivo conditions. Microscopic evaluation showed maintenance of cell viability in the explants for more than 30 days, without the presence of necrosis.
Conclusion
This is the first study involving long‐term 3D primary cultures of benign odontogenic tumours, which is expected to support complex approaches to cell and molecular biology, and serve as an experimental model for testing molecular therapies.
This article is protected by copyright. All rights reserved.
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Controversies in Drug Allergy: Drug Allergy Pathways
Publication date: Available online 17 December 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Anca M. Chiriac, Aleena Banerji, Rebecca S. Gruchalla, Bernard Y.H. Thong, Paige Wickner, Paul-Michel Mertes, Ingrid Terreehorst, Kimberly G. Blumenthal
Drug allergy pathways are standardized approaches for patients reporting prior drug allergies with the aim of quality improvement and promotion of antibiotic stewardship. At the International Drug Allergy Symposium during the 2018 American Academy of Allergy, Asthma, and Immunology/World Allergy Organization Joint Congress in Orlando, Florida, drug allergy pathways were discussed from international perspectives with a focus on beta-lactam allergy pathways and pragmatic approaches for acute care hospitals. In this expert consensus document, we review current pathways, and detail important considerations in devising, implementing, and evaluating beta-lactam allergy pathways for hospitalized patients. We describe the key patient and institutional factors that must be considered in risk stratification, the central feature of pathway design. We detail shared obstacles to widespread beta-lactam allergy pathway implementation and identify potential solutions to address these challenges.
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Controversies in Drug Allergy: Drug Allergy Pathways
Publication date: Available online 17 December 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Anca M. Chiriac, Aleena Banerji, Rebecca S. Gruchalla, Bernard Y.H. Thong, Paige Wickner, Paul-Michel Mertes, Ingrid Terreehorst, Kimberly G. Blumenthal
Drug allergy pathways are standardized approaches for patients reporting prior drug allergies with the aim of quality improvement and promotion of antibiotic stewardship. At the International Drug Allergy Symposium during the 2018 American Academy of Allergy, Asthma, and Immunology/World Allergy Organization Joint Congress in Orlando, Florida, drug allergy pathways were discussed from international perspectives with a focus on beta-lactam allergy pathways and pragmatic approaches for acute care hospitals. In this expert consensus document, we review current pathways, and detail important considerations in devising, implementing, and evaluating beta-lactam allergy pathways for hospitalized patients. We describe the key patient and institutional factors that must be considered in risk stratification, the central feature of pathway design. We detail shared obstacles to widespread beta-lactam allergy pathway implementation and identify potential solutions to address these challenges.
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New on Netflix UK in January: Fifty Shades Darker, Inception and more arrive on streaming service - Daily Mail
January 2019 will bring with it an array of interesting new shows, blockbuster films, and the return of all your favourite binge-worthy programmes.
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The Relationship of Arterial Wall Enhancement Ratio on MRI with the Degree of Inflammation in a Rabbit Aneurysm Model: A Pilot Study
Publication date: Available online 17 December 2018
Source: Academic Radiology
Author(s): Guang-xian Wang, Chao Xia, Jian Liu, Chun Cui, Sheng Lei, Ming-fu Gong, Li Wen, Dong Zhang
Rationale and Objectives
To identify the relationship between enhancement ratio (ER) of aneurysm walls and degrees of inflammation.
Materials and Methods
Twenty-five white rabbits were used in this study; all underwent surgery to isolate the right common carotid artery (RCCA). Twenty rabbits underwent an aneurysm creation procedure, and 5 underwent a control procedure. In the aneurysm creation procedure, there was surgical exposure of the origin of RCCA and temporary occlusion with an aneurysm clip. The distal RCCA was ligated, and the trapped segment was infused with elastase for 20 minutes, after which the clip was removed. In the control procedure, the trapped segment was infused with saline. High-resolution magnetic resonance imaging was performed at weeks 2, 3, 4, and 5 after the procedure, and wall ER was calculated. After MRI, aneurysms were harvested and stained with hematoxylin-eosin. Pearson correlation analysis and scatter plots were used to evaluate the relationship between wall ER and the degree of inflammation. The relationships between the wall ER, the number of inflammatory cells and time were analyzed by linear graphs.
Results
Wall ER positively correlated with inflammatory cell count of the aneurysm wall (r = 0.877, p < 0.001). The relationships between wall ER, the number of inflammatory cells, and time increased and then decreased according linear graphs.
Conclusion
In this study, the aneurysm wall ER was confirmed to be associated with the degree of inflammation on the rabbit aneurysm model.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PKYyPQ
New on Netflix UK in January: Fifty Shades Darker, Inception and more arrive on streaming service - Daily Mail
January 2019 will bring with it an array of interesting new shows, blockbuster films, and the return of all your favourite binge-worthy programmes.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Er1kYH
The Relationship of Arterial Wall Enhancement Ratio on MRI with the Degree of Inflammation in a Rabbit Aneurysm Model: A Pilot Study
Publication date: Available online 17 December 2018
Source: Academic Radiology
Author(s): Guang-xian Wang, Chao Xia, Jian Liu, Chun Cui, Sheng Lei, Ming-fu Gong, Li Wen, Dong Zhang
Rationale and Objectives
To identify the relationship between enhancement ratio (ER) of aneurysm walls and degrees of inflammation.
Materials and Methods
Twenty-five white rabbits were used in this study; all underwent surgery to isolate the right common carotid artery (RCCA). Twenty rabbits underwent an aneurysm creation procedure, and 5 underwent a control procedure. In the aneurysm creation procedure, there was surgical exposure of the origin of RCCA and temporary occlusion with an aneurysm clip. The distal RCCA was ligated, and the trapped segment was infused with elastase for 20 minutes, after which the clip was removed. In the control procedure, the trapped segment was infused with saline. High-resolution magnetic resonance imaging was performed at weeks 2, 3, 4, and 5 after the procedure, and wall ER was calculated. After MRI, aneurysms were harvested and stained with hematoxylin-eosin. Pearson correlation analysis and scatter plots were used to evaluate the relationship between wall ER and the degree of inflammation. The relationships between the wall ER, the number of inflammatory cells and time were analyzed by linear graphs.
Results
Wall ER positively correlated with inflammatory cell count of the aneurysm wall (r = 0.877, p < 0.001). The relationships between wall ER, the number of inflammatory cells, and time increased and then decreased according linear graphs.
Conclusion
In this study, the aneurysm wall ER was confirmed to be associated with the degree of inflammation on the rabbit aneurysm model.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PKYyPQ
Controversies in drug allergy: Testing for delayed reactions
Controversies exist with regard to in vivo approaches to delayed immunologically mediated adverse drug reactions, such as exanthem (maculopapular eruption), drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome/toxic epidermal necrolysis, and fixed drug eruptions. In particular, widespread differences exist between regions and practice on the availability and use of intradermal and patch testing, the standard drug concentrations used, the use of additional drugs in intradermal and patch testing to help determine cross-reactivity, the timing of testing in relation to the occurrence of the adverse drug reaction, the use of testing in specific phenotypes, and the use of oral challenge in conjunction with delayed intradermal and patch testing to ascertain drug tolerance.
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Controversies in drug allergy: In vitro testing
Despite their low frequency, drug hypersensitivity reactions (DHRs) can be serious and result in lifelong sequelae. The diagnosis is critical to avert future reactions and should identify the culprit drug or drugs and safe alternatives. However, making the diagnosis can be complex and challenging. Reliable in vitro tests can offer the potential to improve a diagnosis of DHR and influence medical decision making. Importantly, in vitro testing is frequently not performed as a test in isolation but rather as a component of a diagnostic algorithm along with additional tests.
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