Effect of periodontal treatment on Aggregatibacter actinomycetemcomitans (Aa) colonization and serum IgG levels against Aa serotypes and Omp29 of aggressive periodontitis patients

Abstract

Objective

To evaluate the effect of the periodontal treatment on A. actinomycetemcomitans (Aa) JP2 clone, and the IgG serum levels against its outer membrane protein (Omp29) and Aa serotypes in aggressive periodontitis (AgP).

Subjects and Methods

Seventeen patients with generalized (GAgP), 10 with localized (LAgP) and 10 healthy controls were included. AgP participants were submitted to periodontal treatment – scaling and root planing plus antibiotics (SRP+A). Periodontal parameters, e.g. probing depth [PD] and clinical attachment loss [CAL]), were evaluated at baseline and at 1‐year. Serum IgG against Omp29 and serotypes a, b and c were determined by ELISA. The levels of Aa JP2 clone were determined in subgingival biofilm samples by qPCR.

Results

Periodontal treatment resulted in significant reductions of PD, CAL, and IgG levels against Omp29, serotypes b and c. After therapy, IgG levels against Aa serotypes, as well as the levels of the JP2 clone in AgP became similar to controls. The reduction in JP2 clone count was correlated with a reduction of PD and IgG response against Omp29.

Conclusion

SRP+A decreased IgG levels response against Omp29 and Aa serotypes involved in the disease (b and c), while the serum‐response increased against tne commensal serotype (a), similar to what occurs in periodontally healthy individuals.

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NTN1 gene was risk to NSCLO among Han Chinese Population

Abstract

Objective

Genome wide association studies (GWAS) found NTN1, NOG and the region between CREBBP and ADCY9 were risks to non‐syndromic cleft lip with or without cleft palate (NSCL/P). However, the association of single nucleotide polymorphisms (SNPs) in these genes with NSCL/P in Western China is unknown.

Subjects and Methods

We selected seven SNPs in NTN1, NOG and between CREBBP and ADCY9, then performed transmission disequilibrium test (TDT), parent‐of‐origin effect and sliding window haplotype analysis to test the associations among 302 NSCL/P case‐parent trios from Western Han Chinese.

Results

We found allele G at rs4791774 in NTN1 was significantly over‐transmitted among non‐syndromic cleft lip only (NSCLO) (P=0.0067, OR=1.79, 95%CI: 1.17‐2.74); rs4791774 and rs9915089 tightly linked with each other among NSCL/P (D'=0.87, r²=0.67) and haplotypes carrying the risk allele G at rs4791774 were always found to be over‐transmitted from parents to cases. Motif analysis indicated that allele G at rs4791774 could greatly alter the affinity of Myc_disc7, so allele G at rs4791774 in NTN1 might modulate C‐MYC transcription to participate in the etiology of NSCLO.

Conclusions

Our study suggested allele G at rs4791774 in NTN1 gene is risk for NSCLO, which could greatly increase the risk to have a baby with cleft.

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Issue Information

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Diagnostic and other challenges

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Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy

Summary

In this article, we described the development in the field of allergy as described by Clinical and Experimental Allergy in 2017. Experimental models of allergic disease, basic mechanisms, clinical mechanisms, allergens, asthma and rhinitis and clinical allergy are all covered.

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Best of the Other Journals

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Forthcoming Meetings

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Cover Image

The cover image is based on the Original Article Monocytes accumulate in the airways of children with fatal asthma by Ibon Eguíluz‐Gracia et al, DOI: https://doi.org/10.1111/cea.13265.

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Issue Information

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DXHS5I

Diagnostic and other challenges

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QsS7W3

Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy

Summary

In this article, we described the development in the field of allergy as described by Clinical and Experimental Allergy in 2017. Experimental models of allergic disease, basic mechanisms, clinical mechanisms, allergens, asthma and rhinitis and clinical allergy are all covered.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DYKArg

Best of the Other Journals

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QoRkFR

Forthcoming Meetings

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DUAsQs

Cover Image

The cover image is based on the Original Article Monocytes accumulate in the airways of children with fatal asthma by Ibon Eguíluz‐Gracia et al, DOI: https://doi.org/10.1111/cea.13265.

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Inhibition of autophagy by chloroquine makes chemotherapy in nasopharyngeal carcinoma more efficient

A combination of platinum-based chemotherapy and radiotherapy is the standard treatment for nasopharyngeal carcinoma (NPC). However, the efficacy of chemotherapy has reached a plateau. Many autophagy studies suggest that autophagy can either promote or suppress to cancer progression. Thus, a role of autophagy in the acquisition of chemoradioresistance has recently been a notable event. Therefore, we examined the relationship between autophagy and chemotherapy in NPC.

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Inhibition of autophagy by chloroquine makes chemotherapy in nasopharyngeal carcinoma more efficient

A combination of platinum-based chemotherapy and radiotherapy is the standard treatment for nasopharyngeal carcinoma (NPC). However, the efficacy of chemotherapy has reached a plateau. Many autophagy studies suggest that autophagy can either promote or suppress to cancer progression. Thus, a role of autophagy in the acquisition of chemoradioresistance has recently been a notable event. Therefore, we examined the relationship between autophagy and chemotherapy in NPC.

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Cochlear implantation in far-advanced otosclerosis: hearing results and complications.

Authors: Dumas AR, Schwalje AT, Franco-Vidal V, Bébéar JP, Darrouzet V, Bonnard D Abstract Severe forms of otosclerosis known as far-advanced otosclerosis (FAO) can lead to severe to profound sensorineural hearing loss and can justify cochlear implantation. Because of the pathophysiology of otosclerosis, patients implanted for FAO may experience an increased rate of complications, such as facial nerve stimulation or electrode dislocation, and may have poorer hearing outcomes than expected. This retrospective study aimed to compare cochlear implantation hearing outcomes, surgical difficulties and complications in FAO patients versus non-FAO patients. Moreover, we evaluated whether high resolution computed tomography (CT scan) findings were predictive of perioperative problems, com...

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Report from a Consensus Conference on the treatment of M énière's disease with betahistine: rationale, methodology and results.

Report from a Consensus Conference on the treatment of Ménière's disease with betahistine: rationale, methodology and results. Acta Otorhinolaryngol Ital. 2018 Oct;38(5):460-467 Authors: Casani AP, Guidetti G, Schoenhuber R, Consensus Conference Group Abstract Ménière's disease is a disorder of the inner ear that causes vertigo, tinnitus, fullness and hearing loss. Although several treatments are available, the success rate is reported to be around 70%, similar to placebo. Betahistine, a weak H1 receptor agonist and an effective H3 receptor antagonist, is frequently prescribed for Ménière's disease, especially to reduce recurrent vertigo attacks. The effects of this drug on hearing and other audiological symptoms remains unclear. Given the inconclusive reports in...

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Radiologic measurement of cochlea and hearing preservation rate using slim straight electrode (CI422) and round window approach.

Authors: Skarzynski H, Matusiak M, Furmanek M, Pilka A, Wlodarczyk E, Oldak M, Skarzynski PH Abstract Hearing preservation surgery constitutes a considerable branch of cochlear implantation surgery and is being steadily developed and perfected. The aim of the study was to verify if insertion of a cochlear implant electrode according to individually calculated linear insertion depth improves hearing preservation. We evaluated the relations between the size of a cochlea, insertion depth angle, linear insertion depth and hearing preservation rate (HP) according to Hearing Preservation Classification in a retrospective case review of 54 patients implanted with a slim straight electrode Nucleus CI422 in 2008-2011. Group HP was 0.75 at activation, 0.67 at 12 months (for 53 patients) and ...

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Prediction of hearing recovery in sudden deafness treated with intratympanic steroids.

Authors: Attanasio G, Russo FY, Di Porto E, Cagnoni L, Masci E, Ralli M, Greco A, De Vincentiis M Abstract The present study aims to obtain a probability model allowing prediction of auditory recovery in patients affected by sudden sensorineural hearing loss treated exclusively with intratympanic steroids. A monocentric retrospective chart review of 381 patients has been performed. A Probit model was used to investigate the correlation between the success of treatment (marked or total recovery according to Furuashi's criteria) and the delay between onset of disease and beginning of therapy. The age of patients and audiometric curve shapes were included in the analysis. The results show that delay is negatively correlated with variable success. Considering the entire sample, each da...

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