The role of mitochondria in NLRP3 inflammasome activation

Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Qiuyun Liu, Danyan Zhang, Diyu Hu, Xiangmei Zhou, Yang ZhouAbstractThe NLRP3 inflammasome is a multiprotein platform which is activated upon cellular infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory cytokines like interleukin-1β (IL-1β) and IL-18, and an inflammatory form of cell death termed as pyroptosis. Recent studies have unveiled the pivotal roles of mitochondria in initiation and regulation of the NLRP3 (nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3) inflammasome. NLRP3 activators induce mitochondrial destabilization, NLRP3 deubiquitination, linear ubiquitination of ASC, and externalization or release of mitoch...

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