Association of IL-36 γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer

AbstractIL-1 family cytokines play a dual role in the gut, with different family members contributing either protective or pathogenic effects. IL-36 γ is an IL-1 family cytokine involved in polarizing type-1 immune responses. However, its function in the gut, including in colorectal cancer pathogenesis, is not well appreciated. In a murine model of colon carcinoma, IL-36γ controls tertiary lymphoid structure formation and promotes a type-1 imm une response concurrently with a decrease in expression of immune checkpoint molecules in the tumor microenvironment. Here, we demonstrate that IL-36γ plays a similar role in driving a pro-inflammatory phenotype in human colorectal cancer. We analyzed a cohort of 33 primary colorectal carcinoma tum ors using imaging, flow cytometry, and transcript...

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