Characterization of autoantibodies in primary membranous nephropathy and their clinical significance.

Authors: Stahl RA, Reinhard L, Hoxha E Abstract INTRODUCTION: Membranous nephropathy (MN) is the most common cause of a nephrotic syndrome in Caucasian adults. The identification of target antigens in MN in the last decade has had a major impact on the clinical approach to these patients. Areas covered: Since the discoveries in animal models in the 1980s that circulating autoantibodies induce disease upon in situ binding to glomerular podocytes, many attempts have been undertaken to define the human antigens responsible for disease induction. Only in 2009 was Phospholipase A2 Receptor 1 described as the major antigen responsible for MN onset in about 70% of patients. Subsequently, in 2014 Thrombospondin Type-1 Domain-Containing 7A was identified as a second antigen, accounting for ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QWe9Od