The Atopic March and Atopic Multimorbidity: Many Trajectories, Many Pathways

The "atopic march" recognizes the increased occurrence of asthma and/or allergic rhinitis after atopic dermatitis (AD) onset. Mechanisms for developing atopic comorbidities after AD onset are poorly understood, but may involve the impaired cutaneous barrier, which facilitates cutaneous sensitization . The association may also be driven or amplified in susceptible individuals by a systemic Th2-dominant immune response to cutaneous inflammation. However, these associations may merely involve shared genetic loci and environmental triggers, including microbiome dysregulation, with the temporal sequ ence reflecting tissue-specific peak time of occurrence of each disease, suggesting more of a clustering of disorders than a march. (Source: Journal of Allergy and Clinical Immunology)

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