Melatonin enhances responsiveness to Dichelobacter nodosus vaccine in sheep and increases peripheral blood CD4 T lymphocytes and IgG-expressing B lymphocytes

Publication date: Available online 8 November 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Asunción Ramos, María Prado Míguez, Sara Morgado, Beatriz Sanchez-Correa, Juan J. Gordillo, Javier G. Casado, Raquel Tarazona, Sergio RegodónAbstractThe immunomodulatory functions mediated by melatonin support its use as vaccine adjuvant. Previously, we have demonstrated that melatonin enhances antibody responses in sheep vaccinated against Dichelobacter nodosus. Here, we analyze the effect of melatonin on T and B lymphocyte subsets in peripheral blood of sheep vaccinated against D. nodosus. We also compare the use of melatonin in implants and in injections. Melatonin administration either as implants or by injection produced higher antibody titers against A1 and C serotypes co...

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