Characterization of microRNA profile in IgE-mediated mouse BMMCs degranulation

Publication date: Available online 9 November 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Yanhong Li, Jie Liu, Jiaojiao Zhang, Wenjin Zhang, Zhengli WuAbstractBackgroundMast cells play a central role in innate and adaptive immunity by releasing pre-formed and de novo synthesized mediators, which include microRNAs. Although miRNAs have been confirmed to function in cell proliferation, differentiation, apoptosis, and the immune response, their functions are still limited in mast cells degranulagion.MethodsHere, we survey miRNA expression profiles in activated mouse bone marrow-derived mast cells (BMMCs) with a miRNA microarray and compare the profiles to those from resting BMMCs. Partial miRNAs were selected for confirmation by qPCR, and let-7i was selected for fu...

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