An affinity peptide exerts antiviral activity by strongly binding nervous necrosis virus to block viral entry

Publication date: Available online 4 December 2018Source: Fish & Shellfish ImmunologyAuthor(s): Qiong Zhou, Jing Zhang, Runqing Huang, Siyou Huang, Yujia Wu, Lijie Huang, Jianguo He, Junfeng XieAbstractNervous necrosis virus (NNV) causes viral nervous necrosis (VNN), a disease that leads to almost 100% mortality among larvae and juvenile fish, severely affecting the aquaculture industry. VNN vaccines based on inactivated viruses or virus-like particles (VLPs) are unsuitable for fish fry with immature adaptive immune systems. Here, we applied an anti-NNV strategy based on affinity peptides (AFPs). Three phage display peptide libraries were screened against RBS, the VLP of orange-spotted grouper nervous necrosis virus (OGNNV). From the positive clones, a dodecapeptide with the highest bindin...

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