Antibody responses to chimeric peptides derived from parasite antigens in mice and other animal species

Publication date: February 2019Source: Molecular Immunology, Volume 106Author(s): R.A. Orbegozo-Medina, V. Martínez-Sernández, I. Folgueira, M. Mezo, M. González-Warleta, M.J. Perteguer, F. Romarís, J.M. Leiro, F.M. UbeiraAbstractPeptide vaccines constitute an interesting alternative to classical vaccines due to the possibility of selecting specific epitopes, easy of production and safety. However, an inadequate design may render these peptides poorly immunogenic or lead to undesirable outcomes (e.g., formation of B neoepitopes). As an approach to vaccine development, we evaluated the antibody response to chimeras composed of two or three known B epitopes from Trichinella and Fasciola, and several linkers (GSGSG, GPGPG and KK) in species as different as mice, sheep and turbot. All thes...

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