Early Life Origins of Asthma: A Review of Potential Effectors.

Authors: Bobolea I, Arismendi E, Valero A, Agustí A Abstract There is currently growing evidence that events occurring early in life, both before and after birth, are significantly associated with the risk of asthma, COPD and low lung function later in life. In fact, from conception to death there are continuous, dynamic numbers of gene-environment interactions that determine two fundamental biologic processes, lung development and lung ageing. Over 130 birth cohorts have been initiated in the last 30 years. These birth cohorts have improved our understanding of asthma inception, progression and persistency. In this review, we summarize the main data upon those early life events proven to determine later development and persistence of asthma, such as maternal atopy or smoking, pre...

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