Molecular variants of Leishmania (Viannia) braziliensis trigger distinct patterns of cytokines and chemokines expression in golden hamster

Publication date: February 2019Source: Molecular Immunology, Volume 106Author(s): Felipe Dutra Rêgo, Jordana Rodrigues Barbosa Fradico, Andréa Teixeira-Carvalho, Célia Maria Ferreira GontijoAbstractCutaneous leishmaniasis (CL) mainly caused by Leishmania braziliensis is a chronic inflammatory disease widely spread in Brazil. Genetic variant strains of this parasite have been associated with atypical clinical manifestations of CL in an endemic area in Brazil. Furthermore, these strains have presented distinct biological behaviors in golden hamster, suggesting differential activation of the immune response. In the present study we proposed to evaluate the localized immune response in golden hamsters infected with known molecular variant strains of L. braziliensis, in distinct time points ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QIx6Yo