Publication date: Available online 21 January 2019
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Author(s): Yosuke Iijima, Miki Yamada, Miki Endo, Motohiko Sano, Shunsuke Hino, Takahiro Kaneko, Norio Horie
Abstract
Objective
The present study aimed to identify the characteristics of dysgeusia caused by cancer chemotherapy.
Patients and methods
We investigated 181 patients with oral adverse events from cancer chemotherapy who were referred to an oral surgery clinic.
Results
Oral mucositis, dysgeusia and dry mouth were found in 62 (34.3%), 61 (33.7%) and 28 (15.5%) patients, respectively. Most dysgeusia was grade 1 (95.1%, P < 0.001) and was found in 20 (50.0%), 16 (43.2%) and 5 (27.8%) patients with colorectal, breast and gynecological types of cancer, respectively. Dysgeusia was identified in 14 (70.0%), 13 (76.4%) and 10 (55.6%) patients treated with oxaliplatin, paclitaxel and doxorubicin, respectively. Peripheral neuropathy (PN) was evident in 70 (38.7%) patients, and 40 patients had both PN and dysgeusia. Frequency of dysgeusia was significantly higher in patients with PN than in patients without PN (P < 0.001).
Conclusion
Dysgeusia tended to occur during treatment with oxaliplatin, paclitaxel and doxorubicin, and an association with PN was also suggested.
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