Reply

We read Akiyama's correspondence1 on our findings2 with interest. The concept of the autoinflammatory keratinization diseases (AIKDs) is intriguing. We are glad to join the discussion as to whether this umbrella term could include early-onset generalized pustular psoriasis (GPP) without psoriasis vulgaris (PV) concurrence (GPP without PV). The definition of AIKD includes 4 criteria3 (Table I). We agree that criteria 1 and 3 are clearly met in early-onset GPP without PV. The inflammation site is the epidermis and dermis.

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