Novel Approaches to Block Complement

The complement system may contribute in many ways to transplant injury, being a promising target for specific therapeutic interventions. There is evidence that the monoclonal anti-C5 antibody eculizumab is effective in the prevention and treatment of early antibody-mediated rejection, but terminal complement blockade might be of limited efficiency in chronic rejection. Given the diversity of immunological events triggered by activation steps upstream to C5, in particular, opsonin and anaphylatoxin formation through C3 cleavage, one may argue that, in the specific context of antibody-mediated rejection, inhibition of antibody-triggered classical pathway (CP) activation might be beneficial. Strategies to interfere with key CP component C1 are currently under clinical evaluation and include t...

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Novel Approaches to Block Complement

The complement system may contribute in many ways to transplant injury, being a promising target for specific therapeutic interventions. There is evidence that the monoclonal anti-C5 antibody eculizumab is effective in the prevention and treatment of early antibody-mediated rejection, but terminal complement blockade might be of limited efficiency in chronic rejection. Given the diversity of immunological events triggered by activation steps upstream to C5, in particular, opsonin and anaphylatoxin formation through C3 cleavage, one may argue that, in the specific context of antibody-mediated rejection, inhibition of antibody-triggered classical pathway (CP) activation might be beneficial. Strategies to interfere with key CP component C1 are currently under clinical evaluation and include t...

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The effect of a mixture of Nigella sativa and Thymus vulgaris extracts in children with refractory epilepsies; A randomized trial

Publication date: Available online 27 October 2018

Source: Journal of Herbal Medicine

Author(s): Ali Akbar Momen, Ali Asghar Hemati, Gholamreza Hoshmand, Maryam Heydar Azadzadeh, Reza Azizi Malamiri

Abstract

More than 25% of seizures in children are refractory to anti-seizure medications and need other modalities to control. Recently, herbal agents with anticonvulsive effects on seizure models in animals have received significant attention, but studies that show their impact on seizures in children are scarce. In a randomized, double-blind placebo-controlled cross-over design, we tried to demonstrate the efficacy of a mixture of Nigella sativa and Thymus vulgaris extracts (Epistop) on seizures in a group of children with refractory epilepsies. Twenty-two children with refractory epilepsies were randomly assigned into two sequences to receive Epistop or placebo in a cross-over design. Neither Epistop nor placebo had effects on the seizure frequency and duration over the study period. Only four children experienced clinically substantial seizure frequency (more than 50%) reduction after Epistop administration. These results indicate that a mixture of Nigella sativa and Thymus vulgaris extracts does not affect the seizure frequency and duration in children with refractory seizures. However, a minority of highly selected children with refractory seizures might benefit from the effects of a mixture of these agents' extracts.

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The effect of a mixture of Nigella sativa and Thymus vulgaris extracts in children with refractory epilepsies; A randomized trial

Publication date: Available online 27 October 2018

Source: Journal of Herbal Medicine

Author(s): Ali Akbar Momen, Ali Asghar Hemati, Gholamreza Hoshmand, Maryam Heydar Azadzadeh, Reza Azizi Malamiri

Abstract

More than 25% of seizures in children are refractory to anti-seizure medications and need other modalities to control. Recently, herbal agents with anticonvulsive effects on seizure models in animals have received significant attention, but studies that show their impact on seizures in children are scarce. In a randomized, double-blind placebo-controlled cross-over design, we tried to demonstrate the efficacy of a mixture of Nigella sativa and Thymus vulgaris extracts (Epistop) on seizures in a group of children with refractory epilepsies. Twenty-two children with refractory epilepsies were randomly assigned into two sequences to receive Epistop or placebo in a cross-over design. Neither Epistop nor placebo had effects on the seizure frequency and duration over the study period. Only four children experienced clinically substantial seizure frequency (more than 50%) reduction after Epistop administration. These results indicate that a mixture of Nigella sativa and Thymus vulgaris extracts does not affect the seizure frequency and duration in children with refractory seizures. However, a minority of highly selected children with refractory seizures might benefit from the effects of a mixture of these agents' extracts.

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Hypofractionated radiation therapy in the management of locally advanced NSCLC: a narrative review of the literature on behalf of the Italian Association of Radiation Oncology (AIRO)—Lung Working Group

Abstract

A systematic literature was performed to assess the benefit in terms of effectiveness and feasibility of hypofractionated radiotherapy (HypoRT), with or without chemotherapy (CT), in the treatment of locally advanced non-small cell lung cancer (NSCLC). We have identified all studies, published from 2007 onwards, on patients with locally advanced NSCLC treated with HypoRT with radical intent, with a minimal dose per fraction of 2.4 Gy, with or without concurrent chemotherapy. Twenty-nine studies were identified, for a total of 2614 patients. Patients were divided in the concurrent chemo-radiation therapy group (CT-RT) and radiotherapy alone (RT). In RT group, the delivered dose ranged from 45 to 85.5 Gy, with a dose/fraction from 2.4 to 4 Gy. Actuarial 2-year PFS ranged from 13 to 57.8%, and 1, 2- and 3-year overall survival (OS) ranged from 51.3 to 95%, from 22 to 68.7%, and from 7 to 32%, respectively. Acute Grade ≥ 3 esophagitis occurred in 0–15%, while late esophageal toxicity was 0–16%. Acute pneumonitis occured in 0–44%, whereas late pneumonitis occured in 0–47%, most commonly grade ≤ G3. In CT-RT group, the delivered dose ranged from 52.5 to 75 Gy, with a dose/fraction ranging from 2.4 to 3.5 Gy. Actuarial 2-year PFS ranged from 19 to 57.8%, and OS at 1, 2 and 3 years ranged from 28 to 95%, 38.6 to 68.7%, and 31 to 44%, respectively. Acute Grade 2 and 3 esophagitis occurred in 3–41.7%, while late esophageal toxicity occurred in 0–8.3%. Acute pneumonitis ranged from 0 to 23%, whereas late pneumonitis occured 0–47%. HypoRT seems to be safe in patients with locally advanced NSCLC. The encouraging survival results of several studies analyzed suggest that hypofractionated radiation schemes should be further investigated in the future.

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Hypofractionated radiation therapy in the management of locally advanced NSCLC: a narrative review of the literature on behalf of the Italian Association of Radiation Oncology (AIRO)—Lung Working Group

Abstract

A systematic literature was performed to assess the benefit in terms of effectiveness and feasibility of hypofractionated radiotherapy (HypoRT), with or without chemotherapy (CT), in the treatment of locally advanced non-small cell lung cancer (NSCLC). We have identified all studies, published from 2007 onwards, on patients with locally advanced NSCLC treated with HypoRT with radical intent, with a minimal dose per fraction of 2.4 Gy, with or without concurrent chemotherapy. Twenty-nine studies were identified, for a total of 2614 patients. Patients were divided in the concurrent chemo-radiation therapy group (CT-RT) and radiotherapy alone (RT). In RT group, the delivered dose ranged from 45 to 85.5 Gy, with a dose/fraction from 2.4 to 4 Gy. Actuarial 2-year PFS ranged from 13 to 57.8%, and 1, 2- and 3-year overall survival (OS) ranged from 51.3 to 95%, from 22 to 68.7%, and from 7 to 32%, respectively. Acute Grade ≥ 3 esophagitis occurred in 0–15%, while late esophageal toxicity was 0–16%. Acute pneumonitis occured in 0–44%, whereas late pneumonitis occured in 0–47%, most commonly grade ≤ G3. In CT-RT group, the delivered dose ranged from 52.5 to 75 Gy, with a dose/fraction ranging from 2.4 to 3.5 Gy. Actuarial 2-year PFS ranged from 19 to 57.8%, and OS at 1, 2 and 3 years ranged from 28 to 95%, 38.6 to 68.7%, and 31 to 44%, respectively. Acute Grade 2 and 3 esophagitis occurred in 3–41.7%, while late esophageal toxicity occurred in 0–8.3%. Acute pneumonitis ranged from 0 to 23%, whereas late pneumonitis occured 0–47%. HypoRT seems to be safe in patients with locally advanced NSCLC. The encouraging survival results of several studies analyzed suggest that hypofractionated radiation schemes should be further investigated in the future.

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A Systematic Review of the Role of Penile Rehabilitation in Prostate Cancer Patients Receiving Radiotherapy and Androgen Deprivation Therapy

Publication date: Available online 26 October 2018

Source: Journal of Medical Imaging and Radiation Sciences

Author(s): Wesley Doherty, Pete Bridge

Abstract

Introduction/Background

Treatment-induced erectile dysfunction (ED) is a common side effect of radiotherapy and androgen deprivation therapy (ADT) that impacts on patient quality of life. Penile rehabilitation interventions including pharmacologic and physical therapies aim to reduce the impact of ED. Despite The National Institute for Health and Care Excellence guidelines recommending access to ED services, penile rehabilitation is not widely discussed or implemented. This systematic review aimed to appraise the evidence base for penile rehabilitation and identify evidence-based recommendations for practice.

Methods

A systematic review of the evidence base was undertaken using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Scopus and Medline (EBSCO) databases were searched for articles relevant to penile rehabilitation interventions for prostate radiotherapy patients. Study quality was graded using the Oxford Levels of Evidence and the Scottish Intercollegiate Guidelines Network.

Results

This study identified 19 articles on penile rehabilitation in prostate radiotherapy patients, consisting of eight randomized controlled trials, three systematic reviews, and eight case studies. Findings confirmed the value of early use of phosphodiesterase type 5 inhibitors.

Discussion

Despite the range of available physical and pharmaceutical interventions, relevant research focussed solely on the use of phosphodiesterase type 5 inhibitors. Themes from the reviewed articles indicated that timing of intervention was important with early on-going dosage most useful. There was also an identified need for ongoing prophylactic use during ADT. Evidence, in general, was of low quality and based on quantitative data only.

Conclusion

Additional research into the wider range of penile rehabilitation interventions is urgently required to ensure patients have access to those therapies that are most appropriate for them. A paradigm shift toward qualitative research in the field of penile rehabilitation for prostate cancer patients treated with radiotherapy and ADT may be of value in future studies.

Résumé

Introduction/contexte

La dysfonction érectile (DE) induite par le traitement est un effet secondaire commun de la radiothérapie et du traitement par déprivation androgénique (TDA) qui a une incidence sur la qualité de vie des patients. Les interventions de réadaptation pénienne comprennent les thérapies pharmacologiques et physiques visant à diminuer l'impact de la DE. Malgré les lignes directrices du The National Institute for Health and Care Excellence recommandant l'accès aux services de DE, la préadaptation pénienne n'est pas largement discutée ou appliquée. Cet examen systématique vise à évaluer la base d'éléments probants pour la réadaptation pénienne et à recenser des recommandations fondées sur les éléments probants pour la pratique clinique.

Méthodologie

Un examen systématique des bases de données probantes a été fait en suivant les directives PRISMA. Les recherches ont été faites dans les bases de données Scopus et Medline (EBSCO) pour trouver des articles pourtant sur les interventions en réadaptation pénienne pour les patients en radiothérapie de la prostate. La qualité des études a été évaluée en utilisant les normes Oxford Levels of Evidence et Scottish Intercollegiate Guidelines Network.

Résultats

Cette étude a recensé 19 articles sur la réadaptation pénienne chez des patients de radiothérapie de la prostate, incluant huit études sur des essais contrôlés randomisés, trois examens systématiques et huit études de cas. Les conclusions ont confirmé la valeur de l'utilisation précoce des inhibiteurs de la phosphodiestérase type 5.

Discussion

Malgré la gamme d'interventions physiques et pharmacologiques disponibles, les recherches pertinentes mettent uniquement l'accent sur l'utilisation des inhibiteurs de la phosphodiestérase type 5. Les thèmes des articles examinés indiquent que le moment de l'intervention était important, le dosage continu précoce étant le plus utile. On note également un besoin d'administration prophylactique continue pendant le TDA. De façon générale, les preuves sont de faible qualité et fondées uniquement sur des données quantitatives.

Conclusion

Des recherches additionnelles sur l'éventail étendu d'interventions en réadaptation pénienne sont requises de façon urgente pour que les patients puissent avoir accès aux thérapies les plus appropriées à leur cas. Un changement de paradigme vers la recherche qualitative dans le domaine de la réadaptation pénienne pour les patients en oncologie traités par radiothérapie et TDA pourrait être utile pour les études futures.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PZOCTI

A Systematic Review of the Role of Penile Rehabilitation in Prostate Cancer Patients Receiving Radiotherapy and Androgen Deprivation Therapy

Publication date: Available online 26 October 2018

Source: Journal of Medical Imaging and Radiation Sciences

Author(s): Wesley Doherty, Pete Bridge

Abstract

Introduction/Background

Treatment-induced erectile dysfunction (ED) is a common side effect of radiotherapy and androgen deprivation therapy (ADT) that impacts on patient quality of life. Penile rehabilitation interventions including pharmacologic and physical therapies aim to reduce the impact of ED. Despite The National Institute for Health and Care Excellence guidelines recommending access to ED services, penile rehabilitation is not widely discussed or implemented. This systematic review aimed to appraise the evidence base for penile rehabilitation and identify evidence-based recommendations for practice.

Methods

A systematic review of the evidence base was undertaken using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Scopus and Medline (EBSCO) databases were searched for articles relevant to penile rehabilitation interventions for prostate radiotherapy patients. Study quality was graded using the Oxford Levels of Evidence and the Scottish Intercollegiate Guidelines Network.

Results

This study identified 19 articles on penile rehabilitation in prostate radiotherapy patients, consisting of eight randomized controlled trials, three systematic reviews, and eight case studies. Findings confirmed the value of early use of phosphodiesterase type 5 inhibitors.

Discussion

Despite the range of available physical and pharmaceutical interventions, relevant research focussed solely on the use of phosphodiesterase type 5 inhibitors. Themes from the reviewed articles indicated that timing of intervention was important with early on-going dosage most useful. There was also an identified need for ongoing prophylactic use during ADT. Evidence, in general, was of low quality and based on quantitative data only.

Conclusion

Additional research into the wider range of penile rehabilitation interventions is urgently required to ensure patients have access to those therapies that are most appropriate for them. A paradigm shift toward qualitative research in the field of penile rehabilitation for prostate cancer patients treated with radiotherapy and ADT may be of value in future studies.

Résumé

Introduction/contexte

La dysfonction érectile (DE) induite par le traitement est un effet secondaire commun de la radiothérapie et du traitement par déprivation androgénique (TDA) qui a une incidence sur la qualité de vie des patients. Les interventions de réadaptation pénienne comprennent les thérapies pharmacologiques et physiques visant à diminuer l'impact de la DE. Malgré les lignes directrices du The National Institute for Health and Care Excellence recommandant l'accès aux services de DE, la préadaptation pénienne n'est pas largement discutée ou appliquée. Cet examen systématique vise à évaluer la base d'éléments probants pour la réadaptation pénienne et à recenser des recommandations fondées sur les éléments probants pour la pratique clinique.

Méthodologie

Un examen systématique des bases de données probantes a été fait en suivant les directives PRISMA. Les recherches ont été faites dans les bases de données Scopus et Medline (EBSCO) pour trouver des articles pourtant sur les interventions en réadaptation pénienne pour les patients en radiothérapie de la prostate. La qualité des études a été évaluée en utilisant les normes Oxford Levels of Evidence et Scottish Intercollegiate Guidelines Network.

Résultats

Cette étude a recensé 19 articles sur la réadaptation pénienne chez des patients de radiothérapie de la prostate, incluant huit études sur des essais contrôlés randomisés, trois examens systématiques et huit études de cas. Les conclusions ont confirmé la valeur de l'utilisation précoce des inhibiteurs de la phosphodiestérase type 5.

Discussion

Malgré la gamme d'interventions physiques et pharmacologiques disponibles, les recherches pertinentes mettent uniquement l'accent sur l'utilisation des inhibiteurs de la phosphodiestérase type 5. Les thèmes des articles examinés indiquent que le moment de l'intervention était important, le dosage continu précoce étant le plus utile. On note également un besoin d'administration prophylactique continue pendant le TDA. De façon générale, les preuves sont de faible qualité et fondées uniquement sur des données quantitatives.

Conclusion

Des recherches additionnelles sur l'éventail étendu d'interventions en réadaptation pénienne sont requises de façon urgente pour que les patients puissent avoir accès aux thérapies les plus appropriées à leur cas. Un changement de paradigme vers la recherche qualitative dans le domaine de la réadaptation pénienne pour les patients en oncologie traités par radiothérapie et TDA pourrait être utile pour les études futures.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PZOCTI

Acknowledgment of Reviewers 2016 and 2017

(Source: Dysphagia)

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Functional characterization of an ER-stress responding Crustin gene in Litopenaeus vannamei

In this study, we cloned a new Crustin gene (LvCruU) from Litopenaeus vannamei. We showed that LvCruU has antibacterial activity, and reducing its expression would increase the cumulative mortality of L. vannamei upon the Vibrio parahemolyticus infection. In addition, we found that promoter activity of LvCruU was enhanced not only by the deformed epidermal autoregulatory factor-1 (Deaf1), but also by activating transcription factor 3 (LvATF3) of shrimp UPR. Real-time RT-PCR showed that LvCruU and LvATF3 both were induced upon UPR activation. And moreover, in Thapsigargin plus dsLvCruU injection test, we showed that down-regulation of LvCruU increased the cumulative mortality of V. parahemolyticus-infected shrimp under ER-stress. These results suggest that LvCruU work as a downstream effect...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O9rEaI

Transient enhancement of immune resistance functions in Litopenaeus vannamei through a low-dose octopamine injection

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Use of synthetic and biologic DMARDs during pregnancy.

Authors: Balbi GGM, Domingues V, Balbi GGM, De Jesús GR, Levy RA Abstract INTRODUCTION: Since most of the autoimmune diseases (AID) affect mostly women in their fertile years, and fertility is in general preserved, the use of disease modifying anti-rheumatic drugs (DMARDs) during conception, pregnancy and lactation has been a matter of concern in the treatment of women affect by AID. Areas covered: We performed a comprehensive review of the latest and most relevant research papers published in the field and discussed different aspects related to the use of synthetic and biologic disease-modifying antirheumatic drugs (DMARDs) and immunosuppressants in the preconceptional period, during pregnancy and lactation in AID patients, both in males and females. Expert commentary: Active AID...

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Correction.

Authors: PMID: 30354801 [PubMed - in process] (Source: Expert Review of Clinical Immunology)

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A review of ixekizumab in the treatment of psoriatic arthritis.

Authors: O'Rielly DD, Rahman P Abstract INTRODUCTION: Psoriatic arthritis (PsA) is a heterogeneous inflammatory disorder with articular, peri-articular, and extra-articular features along with selected co-morbidities as a sequela to chronic inflammation. There is accumulating evidence that the Th-17 signaling pathway is of critical importance in PsA pathogenesis. Areas covered: Ixekizumab (IXE) is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody directed against IL-17A. Two phase III randomized clinical trials, SPIRIT-P1 and SPIRIT-P2, unequivocally demonstrated superiority of IXE (80 mg every two or 4 weeks) dosing over placebo in moderate-to-severe PsA patients that failed either NSAIDs, conventional disease-modifying anti-rheumatic drugs (csDMARDs) or tumour ne...

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Les prothèses mammaires : n’oublions pas les implants en sérum physiologique

Publication date: Available online 26 October 2018

Source: Annales de Chirurgie Plastique Esthétique

Author(s): D. Boccara, N. Malca, K. Serror, M.-C. Dutot, M. Chaouat, M. Mimoun

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Évaluation et impact du respect du référentiel ESMO sur la prise en charge des lésions des tissus mous, étude menée au centre de référence de Lorraine

Publication date: Available online 26 October 2018

Source: Annales de Chirurgie Plastique Esthétique

Author(s): J. Genet, J. Salleron, A. Leroux, J.-L. Verhaeghe, E. Simon

Résumé

Introduction

Malgré les recommandations régulières émises par l'European Society for Medical Oncology (ESMO), la prise en charge des lésions des tissus mous est encore trop souvent insuffisante, pouvant aggraver le pronostic fonctionnel mais aussi vital du patient.

Méthode

Une étude a été menée au centre de référence de Lorraine. Tous Les patients inscrits dans la base de données NetSarc, au décours d'un passage en RCP, entre le 1er janvier 2010 et le 1er septembre 2016 ont été inclus. Les critères de conformité de prise en charge ont été établis en utilisant le dernier référentiel ESMO 2014, permettant de distinguer deux groupes, « conforme » et « non conforme » aux recommandations. Une première analyse comparative a été faite entre les deux groupes toutes lésions confondues. Puis une seconde uniquement sur les sarcomes.

Résultats

Au total, 445 patients présentant une lésion des tissus mous ont été inclus, 344 cas ont été traités selon les recommandations de l'ESMO, soit un taux de conformité de 77,3 %% (IC95 % : 73,4 %, 81,2 %). La conformité était meilleure pour le centre de référence que pour les structures périphériques (p < 0,001), avec des taux de conformité respectivement de 88,7 % et 51,6 %. Sur les 247 sarcomes, nous retrouvions un taux de résection R0 meilleur en cas de dossiers conformes 55 % contre 18 % (p < 0,001). Les taux de R1 étaient de 34 % contre 56 % et R2 de 11 contre 26 %. La survie n'était pas liée de manière significative à l'observance des recommandations dans l'analyse univariée. Après ajustement sur les facteurs pronostiques potentiels, en analyse multivariée, les résultats étaient similaires.

Conclusion

Le respect des recommandations de l'ESMO, permet d'améliorer la qualité de l'exérèse chirurgicale des sarcomes et évite les gestes chirurgicaux inappropriés.

Summary

Introduction

Despite regular recommendations issued by the European Society for Medical Oncology (ESMO), patients faced still too often inadequate care with a direct influence on prognosis.

Methods

A retrospective study was carried out at the Competence center in Lorraine Area. Patients registered in the NetSarc database between 1st, 2010 and September 1st, 2016 were included. Compliance criteria were established using the latest ESMO 2014 referential. Two groups "conforming" and "non conforming" were analyzed. A first analyze about all of the soft tissue lesion and a second only about sarcomas.

Results

In total, 445 patients were eligible, 344 cases were treated according to the ESMO guidelines, giving a 77.3% conformity rate (95% CI: 73.4%, 81.2%). Compliance was better for the competence center than district hospitals (P < 0.001), with compliance rates of 88.7%, and 51.6%, respectively. Among the 247 sarcomas, we found a R0 resection rate better according to the ESMO guideline, 55% against 18% (P < 0.001). R1 rates were 34% vs. 56% and R2 11 vs. 26% disease free survival was not related significantly to the observance of recommendations in the univariate analysis. After adjustment on potential DFS prognostic factors, in the multivariate analysis, the results were similar.

Conclusion

Compliance with the ESMO guidelines, through appropriate management, improves the quality of surgical excision for sarcomas and avoids non-corresponding surgical gestures.

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Acknowledgment of Reviewers 2016 and 2017

(Source: Dysphagia)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OTg9d2

Functional characterization of an ER-stress responding Crustin gene in Litopenaeus vannamei

In this study, we cloned a new Crustin gene (LvCruU) from Litopenaeus vannamei. We showed that LvCruU has antibacterial activity, and reducing its expression would increase the cumulative mortality of L. vannamei upon the Vibrio parahemolyticus infection. In addition, we found that promoter activity of LvCruU was enhanced not only by the deformed epidermal autoregulatory factor-1 (Deaf1), but also by activating transcription factor 3 (LvATF3) of shrimp UPR. Real-time RT-PCR showed that LvCruU and LvATF3 both were induced upon UPR activation. And moreover, in Thapsigargin plus dsLvCruU injection test, we showed that down-regulation of LvCruU increased the cumulative mortality of V. parahemolyticus-infected shrimp under ER-stress. These results suggest that LvCruU work as a downstream effect...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O9rEaI

Transient enhancement of immune resistance functions in Litopenaeus vannamei through a low-dose octopamine injection

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVq4yI

Use of synthetic and biologic DMARDs during pregnancy.

Authors: Balbi GGM, Domingues V, Balbi GGM, De Jesús GR, Levy RA Abstract INTRODUCTION: Since most of the autoimmune diseases (AID) affect mostly women in their fertile years, and fertility is in general preserved, the use of disease modifying anti-rheumatic drugs (DMARDs) during conception, pregnancy and lactation has been a matter of concern in the treatment of women affect by AID. Areas covered: We performed a comprehensive review of the latest and most relevant research papers published in the field and discussed different aspects related to the use of synthetic and biologic disease-modifying antirheumatic drugs (DMARDs) and immunosuppressants in the preconceptional period, during pregnancy and lactation in AID patients, both in males and females. Expert commentary: Active AID...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OaRUlo

Correction.

Authors: PMID: 30354801 [PubMed - in process] (Source: Expert Review of Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ORjObl

A review of ixekizumab in the treatment of psoriatic arthritis.

Authors: O'Rielly DD, Rahman P Abstract INTRODUCTION: Psoriatic arthritis (PsA) is a heterogeneous inflammatory disorder with articular, peri-articular, and extra-articular features along with selected co-morbidities as a sequela to chronic inflammation. There is accumulating evidence that the Th-17 signaling pathway is of critical importance in PsA pathogenesis. Areas covered: Ixekizumab (IXE) is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody directed against IL-17A. Two phase III randomized clinical trials, SPIRIT-P1 and SPIRIT-P2, unequivocally demonstrated superiority of IXE (80 mg every two or 4 weeks) dosing over placebo in moderate-to-severe PsA patients that failed either NSAIDs, conventional disease-modifying anti-rheumatic drugs (csDMARDs) or tumour ne...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O8XcxF

Les prothèses mammaires : n’oublions pas les implants en sérum physiologique

Publication date: Available online 26 October 2018

Source: Annales de Chirurgie Plastique Esthétique

Author(s): D. Boccara, N. Malca, K. Serror, M.-C. Dutot, M. Chaouat, M. Mimoun

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Snezy7

Évaluation et impact du respect du référentiel ESMO sur la prise en charge des lésions des tissus mous, étude menée au centre de référence de Lorraine

Publication date: Available online 26 October 2018

Source: Annales de Chirurgie Plastique Esthétique

Author(s): J. Genet, J. Salleron, A. Leroux, J.-L. Verhaeghe, E. Simon

Résumé

Introduction

Malgré les recommandations régulières émises par l'European Society for Medical Oncology (ESMO), la prise en charge des lésions des tissus mous est encore trop souvent insuffisante, pouvant aggraver le pronostic fonctionnel mais aussi vital du patient.

Méthode

Une étude a été menée au centre de référence de Lorraine. Tous Les patients inscrits dans la base de données NetSarc, au décours d'un passage en RCP, entre le 1er janvier 2010 et le 1er septembre 2016 ont été inclus. Les critères de conformité de prise en charge ont été établis en utilisant le dernier référentiel ESMO 2014, permettant de distinguer deux groupes, « conforme » et « non conforme » aux recommandations. Une première analyse comparative a été faite entre les deux groupes toutes lésions confondues. Puis une seconde uniquement sur les sarcomes.

Résultats

Au total, 445 patients présentant une lésion des tissus mous ont été inclus, 344 cas ont été traités selon les recommandations de l'ESMO, soit un taux de conformité de 77,3 %% (IC95 % : 73,4 %, 81,2 %). La conformité était meilleure pour le centre de référence que pour les structures périphériques (p < 0,001), avec des taux de conformité respectivement de 88,7 % et 51,6 %. Sur les 247 sarcomes, nous retrouvions un taux de résection R0 meilleur en cas de dossiers conformes 55 % contre 18 % (p < 0,001). Les taux de R1 étaient de 34 % contre 56 % et R2 de 11 contre 26 %. La survie n'était pas liée de manière significative à l'observance des recommandations dans l'analyse univariée. Après ajustement sur les facteurs pronostiques potentiels, en analyse multivariée, les résultats étaient similaires.

Conclusion

Le respect des recommandations de l'ESMO, permet d'améliorer la qualité de l'exérèse chirurgicale des sarcomes et évite les gestes chirurgicaux inappropriés.

Summary

Introduction

Despite regular recommendations issued by the European Society for Medical Oncology (ESMO), patients faced still too often inadequate care with a direct influence on prognosis.

Methods

A retrospective study was carried out at the Competence center in Lorraine Area. Patients registered in the NetSarc database between 1st, 2010 and September 1st, 2016 were included. Compliance criteria were established using the latest ESMO 2014 referential. Two groups "conforming" and "non conforming" were analyzed. A first analyze about all of the soft tissue lesion and a second only about sarcomas.

Results

In total, 445 patients were eligible, 344 cases were treated according to the ESMO guidelines, giving a 77.3% conformity rate (95% CI: 73.4%, 81.2%). Compliance was better for the competence center than district hospitals (P < 0.001), with compliance rates of 88.7%, and 51.6%, respectively. Among the 247 sarcomas, we found a R0 resection rate better according to the ESMO guideline, 55% against 18% (P < 0.001). R1 rates were 34% vs. 56% and R2 11 vs. 26% disease free survival was not related significantly to the observance of recommendations in the univariate analysis. After adjustment on potential DFS prognostic factors, in the multivariate analysis, the results were similar.

Conclusion

Compliance with the ESMO guidelines, through appropriate management, improves the quality of surgical excision for sarcomas and avoids non-corresponding surgical gestures.

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The 2018 Nobel Prize in Physiology or Medicine: An exemplar of Bench to Bedside in Immunology

Publication date: Available online 26 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Zuhair K. Ballas

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Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients

Publication date: Available online 26 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Dan Davini, Fouzia Naeem, Aron Phong, Mufadhal Al-Kuhlani, Kristen M. Valentine, James McCarty, David M. Ojcius, David M. Gravano, Katrina K. Hoyer

Summary

The inability to resolve Coccidioides infection correlates with elevated Treg frequency and functional marker expression at diagnosis. Treg frequency may be a diagnostic for calibrating treatment aggressiveness for patients likely to develop chronic cocciodiomycosis.

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The 2018 Nobel Prize in Physiology or Medicine: An exemplar of Bench to Bedside in Immunology

Publication date: Available online 26 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Zuhair K. Ballas

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Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients

Publication date: Available online 26 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Dan Davini, Fouzia Naeem, Aron Phong, Mufadhal Al-Kuhlani, Kristen M. Valentine, James McCarty, David M. Ojcius, David M. Gravano, Katrina K. Hoyer

Summary

The inability to resolve Coccidioides infection correlates with elevated Treg frequency and functional marker expression at diagnosis. Treg frequency may be a diagnostic for calibrating treatment aggressiveness for patients likely to develop chronic cocciodiomycosis.

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The Use of Video Glasses Improved Learning of Tonsillectomy and Adenoidectomy Surgery: A Randomized Controlled Trial

Publication date: Available online 27 October 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Evie Landry, Michael Yong, Julie Pauwels, Neil K. Chadha

Abstract

Objective

One of the most common challenges in surgical education for trainees is gaining practical experience through observing procedures in the operating room. Due to the nature of some procedures, a narrow surgical view severely limits the learning experience. Video glasses are new devices that offer the potential to project the primary surgeon's exact view to learners in real-time, allowing for an enhanced operative learning experience.

Study Design

Single center randomized prospective trial.

Setting

Tertiary care pediatric hospital.

Participants

Using block randomization, medical students and surgical residents observed either a tonsillectomy or adenoidectomy, either directly at table-side or by real-time video feed from the surgeon's video glasses projected to a screen in the operating room, in random order. Participants then completed a survey comparing aspects of their learning experience viewing the procedure through the video feed in comparison to direct observation.

Main Outcome

Measures: Evaluating the hypothesis that video glasses provided an improved overall learning experience and a realistic simulation of the open surgical procedures tested.

Results

23 trainees participated in the study. Survey results demonstrated that the overall learning experience with the use of video glasses was significantly improved when compared to direct visualization (average Visual Analog scale (VAS) score 82/100 vs. 64/100, p=0.021).Video glasses were shown to be superior when comparing the view of the surgical field (83/100 vs. 54/100 on VAS, p<0.001) and the ability to identify anatomical structures (79/100 vs. 56/100 on VAS, p=0.001). The ease of following surgical steps with video glasses was also shown to be better than by direct visualization (81/100 vs. 69/100 on VAS, p=0.039). All participants stated that video glasses closely simulated the learning environment of the real-life open procedure.

Conclusion

This study showed that the use of video glasses was beneficial for surgical education and a realistic tool for learners at varying levels of training. Video glasses may significantly improve the learning experience for procedures with a narrow field of view.

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Prediction of uptake and retention of conventional hearing aids in Korean pediatric patients with unilateral hearing loss

Publication date: Available online 26 October 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Hyesook Lee, Hyunyong Lee, Heil Noh

Abstract

Objective

The purpose of this study was to describe and predict hearing aid uptake and retention in Korean pediatric patients with unilateral hearing loss (UHL) in a secondary referral hospital.

Methods

This was a retrospective study using clinical data collected at the time of UHL diagnosis. The study included data collected from 2009 to 2016. Serial audiograms were extracted from clinical charts, and follow-up status and rehabilitation decisions were analyzed.

Results

Of 102 children and adolescents (9.5±5.1 years, 64 male), 52.9% followed a check-up schedule, and 31 (30.4%) obtained a hearing aid. Hearing threshold and speech discrimination scores were predictive parameters of hearing aid uptake. Among those who used a hearing aid, 17 (56.7%) subjects used it successfully based on significant predictive parameters of channel number.

Conclusion

Hearing aid retention in pediatric patients seems less predictable than in adults with UHL. No good predictable parameter for hearing aid retention was identified except channel number for pediatric UHL cases. Regular monitoring of hearing and selection of a multi-channel hearing aid are crucial to minimize the potential negative effects of UHL.

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The Use of Video Glasses Improved Learning of Tonsillectomy and Adenoidectomy Surgery: A Randomized Controlled Trial

Publication date: Available online 27 October 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Evie Landry, Michael Yong, Julie Pauwels, Neil K. Chadha

Abstract

Objective

One of the most common challenges in surgical education for trainees is gaining practical experience through observing procedures in the operating room. Due to the nature of some procedures, a narrow surgical view severely limits the learning experience. Video glasses are new devices that offer the potential to project the primary surgeon's exact view to learners in real-time, allowing for an enhanced operative learning experience.

Study Design

Single center randomized prospective trial.

Setting

Tertiary care pediatric hospital.

Participants

Using block randomization, medical students and surgical residents observed either a tonsillectomy or adenoidectomy, either directly at table-side or by real-time video feed from the surgeon's video glasses projected to a screen in the operating room, in random order. Participants then completed a survey comparing aspects of their learning experience viewing the procedure through the video feed in comparison to direct observation.

Main Outcome

Measures: Evaluating the hypothesis that video glasses provided an improved overall learning experience and a realistic simulation of the open surgical procedures tested.

Results

23 trainees participated in the study. Survey results demonstrated that the overall learning experience with the use of video glasses was significantly improved when compared to direct visualization (average Visual Analog scale (VAS) score 82/100 vs. 64/100, p=0.021).Video glasses were shown to be superior when comparing the view of the surgical field (83/100 vs. 54/100 on VAS, p<0.001) and the ability to identify anatomical structures (79/100 vs. 56/100 on VAS, p=0.001). The ease of following surgical steps with video glasses was also shown to be better than by direct visualization (81/100 vs. 69/100 on VAS, p=0.039). All participants stated that video glasses closely simulated the learning environment of the real-life open procedure.

Conclusion

This study showed that the use of video glasses was beneficial for surgical education and a realistic tool for learners at varying levels of training. Video glasses may significantly improve the learning experience for procedures with a narrow field of view.

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Prediction of uptake and retention of conventional hearing aids in Korean pediatric patients with unilateral hearing loss

Publication date: Available online 26 October 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Hyesook Lee, Hyunyong Lee, Heil Noh

Abstract

Objective

The purpose of this study was to describe and predict hearing aid uptake and retention in Korean pediatric patients with unilateral hearing loss (UHL) in a secondary referral hospital.

Methods

This was a retrospective study using clinical data collected at the time of UHL diagnosis. The study included data collected from 2009 to 2016. Serial audiograms were extracted from clinical charts, and follow-up status and rehabilitation decisions were analyzed.

Results

Of 102 children and adolescents (9.5±5.1 years, 64 male), 52.9% followed a check-up schedule, and 31 (30.4%) obtained a hearing aid. Hearing threshold and speech discrimination scores were predictive parameters of hearing aid uptake. Among those who used a hearing aid, 17 (56.7%) subjects used it successfully based on significant predictive parameters of channel number.

Conclusion

Hearing aid retention in pediatric patients seems less predictable than in adults with UHL. No good predictable parameter for hearing aid retention was identified except channel number for pediatric UHL cases. Regular monitoring of hearing and selection of a multi-channel hearing aid are crucial to minimize the potential negative effects of UHL.

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Albumin Plasma Exchange For Life Threatening Angioedema With Normal C1-Inhibitor

Publication date: Available online 26 October 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Danny M. Cohn, Sacha S. Zeerleder, Joost C.M. Meijers, Erik S.G. Stroes, Marcel Levi

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Pricking Away At Penicillin Allergy with a Dedicated Outpatient Clinic

Publication date: Available online 26 October 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Renee Kleris, Monica Tang, Cristine Radojicic, Patricia L. Lugar

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Albumin Plasma Exchange For Life Threatening Angioedema With Normal C1-Inhibitor

Publication date: Available online 26 October 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Danny M. Cohn, Sacha S. Zeerleder, Joost C.M. Meijers, Erik S.G. Stroes, Marcel Levi

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Pricking Away At Penicillin Allergy with a Dedicated Outpatient Clinic

Publication date: Available online 26 October 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Renee Kleris, Monica Tang, Cristine Radojicic, Patricia L. Lugar

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A robust alternative estimator for small to moderate sample SEM: Bias-corrected factor score path analysis

Publication date: Available online 27 October 2018

Source: Addictive Behaviors

Author(s): Ben Kelcey

Abstract

Structural equation modeling using full information maximum likelihood is the predominant method to empirically assess complex theories involving multiple latent variables in addiction research. Although full information estimators have many desirable properties including consistency, a major limitation in structural equation models is that they often sustain significant bias when implemented in small to moderate size studies (e.g., fewer than 100 or 200). Recent literature has developed a limited information estimator designed to address this limitation—implemented through a bias-corrected factor score path analysis approach—that has been shown to produce unbiased and efficient estimates in small to moderate sample settings. Despite its theoretical and empirical merits, literature has suggested that the method is underused because of three primary reasons—the methods are unfamiliar to applied researchers, there is a lack of practical and accessible guidance and software available for applied researchers, and comparisons against full information methods that are grounded in discipline-specific examples are lacking. In this study, I delineate this method through a step-by-step example analysis of a sequential mediation involving internet addiction. I provide example R code using the lavaan package and data based on a hypothetical study of addiction. I examine the differences between the full and limited information estimators within the example data and subsequently probe the extent to which these differences are indicative of a consistent divergence between the estimators using a simulation study. The results suggest that the limited information estimator outperforms the conventional full information maximum likelihood estimator in small to moderate sample sizes in terms of bias, efficiency, and power.

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Cigarette smoking rates among veterans: Association with rurality and psychiatric disorders

Publication date: Available online 26 October 2018

Source: Addictive Behaviors

Author(s): Lara N. Coughlin, Sarah M. Wilson, Meredith C. Erwin, Jean C. Beckham, Patrick S. Calhoun, VA Mid-Atlantic MIRECC Workgroup

Abstract

Aims

Compared to the general U.S. population, military veterans and those living in rural areas disproportionately smoke cigarettes at higher rates, leading to increased health consequences. In the current study, prevalence and severity of cigarette smoking in Iraq and Afghanistan era veterans was assessed across rural and urban areas and comorbid mental health disorders.

Method

Iraq/Afghanistan era veterans who participated in the Post-Deployment Mental Health study from 2005 to 2017 (N = 3229) were cross-sectionally assessed for the probability of being a current cigarette smoker based on locality status and psychiatric comorbidity. Multivariate logistic and linear regressions, adjusted for demographic characteristics, were used to model the odds of being a current smoker and the severity of nicotine dependence, respectively.

Results

Veterans residing in rural regions, veterans with psychiatric comorbidities, and the interaction of locality and psychiatric disorders were significantly associated with smoking rates. Those veterans living in extremely rural areas and, independently, those living with psychiatric comorbidities were also more severely dependent on nicotine compared to urban veterans and veterans without psychiatric conditions.

Conclusions

Rural veterans and veterans with psychiatric comorbidities are at increased risk of smoking and are more severely dependent on nicotine than urban veterans. These findings underscore the need to reduce barriers for treatment both for smoking cessation and mental healthcare for veterans residing in the most rural areas.

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A robust alternative estimator for small to moderate sample SEM: Bias-corrected factor score path analysis

Publication date: Available online 27 October 2018

Source: Addictive Behaviors

Author(s): Ben Kelcey

Abstract

Structural equation modeling using full information maximum likelihood is the predominant method to empirically assess complex theories involving multiple latent variables in addiction research. Although full information estimators have many desirable properties including consistency, a major limitation in structural equation models is that they often sustain significant bias when implemented in small to moderate size studies (e.g., fewer than 100 or 200). Recent literature has developed a limited information estimator designed to address this limitation—implemented through a bias-corrected factor score path analysis approach—that has been shown to produce unbiased and efficient estimates in small to moderate sample settings. Despite its theoretical and empirical merits, literature has suggested that the method is underused because of three primary reasons—the methods are unfamiliar to applied researchers, there is a lack of practical and accessible guidance and software available for applied researchers, and comparisons against full information methods that are grounded in discipline-specific examples are lacking. In this study, I delineate this method through a step-by-step example analysis of a sequential mediation involving internet addiction. I provide example R code using the lavaan package and data based on a hypothetical study of addiction. I examine the differences between the full and limited information estimators within the example data and subsequently probe the extent to which these differences are indicative of a consistent divergence between the estimators using a simulation study. The results suggest that the limited information estimator outperforms the conventional full information maximum likelihood estimator in small to moderate sample sizes in terms of bias, efficiency, and power.

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Cigarette smoking rates among veterans: Association with rurality and psychiatric disorders

Publication date: Available online 26 October 2018

Source: Addictive Behaviors

Author(s): Lara N. Coughlin, Sarah M. Wilson, Meredith C. Erwin, Jean C. Beckham, Patrick S. Calhoun, VA Mid-Atlantic MIRECC Workgroup

Abstract

Aims

Compared to the general U.S. population, military veterans and those living in rural areas disproportionately smoke cigarettes at higher rates, leading to increased health consequences. In the current study, prevalence and severity of cigarette smoking in Iraq and Afghanistan era veterans was assessed across rural and urban areas and comorbid mental health disorders.

Method

Iraq/Afghanistan era veterans who participated in the Post-Deployment Mental Health study from 2005 to 2017 (N = 3229) were cross-sectionally assessed for the probability of being a current cigarette smoker based on locality status and psychiatric comorbidity. Multivariate logistic and linear regressions, adjusted for demographic characteristics, were used to model the odds of being a current smoker and the severity of nicotine dependence, respectively.

Results

Veterans residing in rural regions, veterans with psychiatric comorbidities, and the interaction of locality and psychiatric disorders were significantly associated with smoking rates. Those veterans living in extremely rural areas and, independently, those living with psychiatric comorbidities were also more severely dependent on nicotine compared to urban veterans and veterans without psychiatric conditions.

Conclusions

Rural veterans and veterans with psychiatric comorbidities are at increased risk of smoking and are more severely dependent on nicotine than urban veterans. These findings underscore the need to reduce barriers for treatment both for smoking cessation and mental healthcare for veterans residing in the most rural areas.

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Local Anesthesia for Pediatric Cochlear Implant

Condition:   Anesthesia, Local Interventions:   Drug: Lidocaine 1%/Epi 1:200000;   Other: Na Cl 0.9%/Epi 1:200000 Sponsor:   Ain Shams University Completed (Source: ClinicalTrials.gov)

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Local Anesthesia for Pediatric Cochlear Implant

Condition:   Anesthesia, Local Interventions:   Drug: Lidocaine 1%/Epi 1:200000;   Other: Na Cl 0.9%/Epi 1:200000 Sponsor:   Ain Shams University Completed (Source: ClinicalTrials.gov)

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A practical approach to limit the radiation dose from building materials applied in dwellings, in compliance with the Euratom Basic Safety Standards

Publication date: January 2019

Source: Journal of Environmental Radioactivity, Volume 196

Author(s): Ronald C.G.M. Smetsers, Jasper M. Tomas

Abstract

Individuals receive a significant part of their radiation exposure indoors. We anticipate that this exposure is likely to increase in the near future, due to a growing use in the building industry of recycled materials and materials previously regarded as waste. Such materials often contain elevated levels of natural radionuclides. Directive 2013/59/Euratom ('Basic Safety Standards', BSS) pays comprehensive attention to indoor exposure from natural radionuclides, but proper implementation of all corresponding BSS regulations is not straightforward, especially when regarding the regulation of building materials containing so-called Annex XIII materials. In this paper, we discuss the most relevant deficiencies in the BSS and present a practical approach to cope with these. Our most important observation is that adequate methods for assessing the annual dose due to gamma radiation from building materials are not provided by the BSS. This is in particular difficult because compliance of single building materials has to be tested, but the corresponding BSS reference level refers to gamma radiation emitted by all building materials present in a room. Based on a simple model of three layers of building materials, we present a set of operational conditions for building materials, either used for construction purposes ('bulk layers') or for the finishing of walls, floors and ceilings ('superficial layers'). Any customary combination of building materials meeting these conditions will stay below the BSS reference level for gamma radiation. This statement holds for the middle of a reference room, but is not always the case close to the walls, especially when low density materials with a relatively high content of natural radionuclides are present at the inner side of the room. This can be avoided by applying more strict conditions for those kind of materials than presented in this paper. We further focus on the indoor exposure to thoron progeny. Building materials that pass the test for gamma radiation can still be a significant source for indoor air concentrations of thoron progeny. When the average annual thoron inhalation dose were to be restricted to 1 mSv a⁻¹ − a level comparable to the BSS reference level for gamma radiation − the activity concentration of Ra-224 in (especially porous) building materials used for wall finishing purposes should be limited to a value of typically 50 Bq kg⁻¹. Even if our suggested approach of the BSS regulations is fully implemented, it still allows for a significant increase in the average radiation exposure in dwellings due to external radiation and thoron progeny. However, the situation will be worse if a less strict interpretation of the BSS regulations will be applied.

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A practical approach to limit the radiation dose from building materials applied in dwellings, in compliance with the Euratom Basic Safety Standards

Publication date: January 2019

Source: Journal of Environmental Radioactivity, Volume 196

Author(s): Ronald C.G.M. Smetsers, Jasper M. Tomas

Abstract

Individuals receive a significant part of their radiation exposure indoors. We anticipate that this exposure is likely to increase in the near future, due to a growing use in the building industry of recycled materials and materials previously regarded as waste. Such materials often contain elevated levels of natural radionuclides. Directive 2013/59/Euratom ('Basic Safety Standards', BSS) pays comprehensive attention to indoor exposure from natural radionuclides, but proper implementation of all corresponding BSS regulations is not straightforward, especially when regarding the regulation of building materials containing so-called Annex XIII materials. In this paper, we discuss the most relevant deficiencies in the BSS and present a practical approach to cope with these. Our most important observation is that adequate methods for assessing the annual dose due to gamma radiation from building materials are not provided by the BSS. This is in particular difficult because compliance of single building materials has to be tested, but the corresponding BSS reference level refers to gamma radiation emitted by all building materials present in a room. Based on a simple model of three layers of building materials, we present a set of operational conditions for building materials, either used for construction purposes ('bulk layers') or for the finishing of walls, floors and ceilings ('superficial layers'). Any customary combination of building materials meeting these conditions will stay below the BSS reference level for gamma radiation. This statement holds for the middle of a reference room, but is not always the case close to the walls, especially when low density materials with a relatively high content of natural radionuclides are present at the inner side of the room. This can be avoided by applying more strict conditions for those kind of materials than presented in this paper. We further focus on the indoor exposure to thoron progeny. Building materials that pass the test for gamma radiation can still be a significant source for indoor air concentrations of thoron progeny. When the average annual thoron inhalation dose were to be restricted to 1 mSv a⁻¹ − a level comparable to the BSS reference level for gamma radiation − the activity concentration of Ra-224 in (especially porous) building materials used for wall finishing purposes should be limited to a value of typically 50 Bq kg⁻¹. Even if our suggested approach of the BSS regulations is fully implemented, it still allows for a significant increase in the average radiation exposure in dwellings due to external radiation and thoron progeny. However, the situation will be worse if a less strict interpretation of the BSS regulations will be applied.

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Current pharmacotherapeutic options for pediatric lower respiratory tract infections with a focus on antimicrobial agents.

Authors: Matera MG, Rogliani P, Ora J, Cazzola M Abstract INTRODUCTION: Antibiotics are frequently prescribed to children in the community and in nosocomial settings, mainly because of lower respiratory tract infections(LRTIs), which include influenza, bronchitis, bronchiolitis, pneumonia, and tuberculosis, in addition to bronchiectasis and cystic fibrosis lung disease. It is important to note, however, that more than 50% of these prescriptions are unnecessary or inappropriate. Areas covered: The current choice of antimicrobial therapy for etiological agents of LRTIs is examined and discussed considering each type of LRTI. Expert opinion: There is a clear need for the appropriate utilization of antibiotics in children. Therefore, accurate drug selection and choice of best dosage an...

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Synergism Between Immune-Driven Illnesses and TBI Predicts Suicidal Behavior: A Danish Registers Based Study

To capitalize on the robust capabilities of the Danish registers to estimate interactions between history of immune mediated clinical conditions (infections, allergy and autoimmune) and traumatic brain injury (TBI) future predicting future suicidal self directed violence (SSDV). (Source: Archives of Physical Medicine and Rehabilitation)

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Synergism Between Immune-Driven Illnesses and TBI Predicts Suicidal Behavior: A Danish Registers Based Study

To capitalize on the robust capabilities of the Danish registers to estimate interactions between history of immune mediated clinical conditions (infections, allergy and autoimmune) and traumatic brain injury (TBI) future predicting future suicidal self directed violence (SSDV). (Source: Archives of Physical Medicine and Rehabilitation)

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Emotion Words Modulate Early Conflict Processing in a Flanker Task: Differentiating Emotion-Label Words and Emotion-Laden Words in Second Language.

Authors: Zhang J, Teo T, Wu C Abstract Emotion words modulate conflict processing, even at an early stage (i.e., N200). However, the previous studies implicitly mixed emotion-label words and emotion-laden words together and mostly concentrated on first language (L1) rather than on second language (L2). The current study aimed to investigate whether L2 negative emotion-label words, negative emotion-laden words, and neutral words would affect conflict processing in a flanker task by using event-related potential (ERP) measurements. Twenty Chinese-English bilinguals completed a modified flanker task to decide the color of the target words. The results revealed that only L2 negative emotion-label words elicited larger left frontal N200 in the incongruent condition than in the congruent...

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Endoscopic Management of Lacrimal System Dysgenesis and Dacryocystoceles in Fraser Syndrome: A Case Report and Literature Review.

Endoscopic Management of Lacrimal System Dysgenesis and Dacryocystoceles in Fraser Syndrome: A Case Report and Literature Review.

Allergy Rhinol (Providence). 2018 Jan-Dec;9:2152656718804905

Authors: Falls ME, Rabinowitz MP, Carrasco JR, Rabinowitz MR

Abstract
Background: Fraser syndrome is an autosomal recessive disorder characterized primarily by syndactyly, cryptophthalmos, urinary tract anomalies, ambiguous genitalia, and laryngeal anomalies. A 28-year-old man with Fraser syndrome presented with cryptophthalmos, microphthalmia, lacrimal system dysgenesis, and chronic sinusitis.
Objective: The patients' clinical condition and surgical treatment are described. A literature review was conducted, and articles relevant to the case are presented.
Methods: Case report.
Results: To our knowledge, this is the first published case report of endonasal management of dacryocystoceles in a Fraser syndrome patient. The patient was treated via endoscopic endonasal marsupialization and drainage.
Conclusion: Fraser syndrome patients may initially present to many different specialties as the spectrum of clinical manifestations is broad. Physicians treating these patients should take a collaborative approach to surgical and medical management.

PMID: 30364810 [PubMed]

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A Phase 1/2a Study of PGT121 and VRC07-523LS Monoclonal Antibodies in HIV-uninfected and HIV-infected Adults

Condition:   HIV/AIDS Intervention:   Biological: PGT121 + VRC07-523LS Sponsors:   International AIDS Vaccine Initiative;   Beth Israel Deaconess Medical Center;   Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Not yet recruiting (Source: ClinicalTrials.gov)

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Perception of American-English Vowels by Early and Late Spanish-English Bilinguals.

Authors: Baigorri M, Campanelli L, Levy ES Abstract Increasing numbers of Hispanic immigrants are entering the US and learning American-English (AE) as a second language (L2). Previous studies investigating the relationship between AE and Spanish vowels have revealed an advantage for early L2 learners for their accuracy of L2 vowel perception. Replicating and extending such previous research, this study examined the patterns with which early and late Spanish-English bilingual adults assimilated naturally-produced AE vowels to their native vowel inventory and the accuracy with which they discriminated the vowels. Twelve early Spanish-English bilingual, 12 late Spanish-English bilingual, and 10 monolingual listeners performed perceptual-assimilation and categorical-discrimination tas...

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Endoscopic Management of Lacrimal System Dysgenesis and Dacryocystoceles in Fraser Syndrome: A Case Report and Literature Review.

Endoscopic Management of Lacrimal System Dysgenesis and Dacryocystoceles in Fraser Syndrome: A Case Report and Literature Review.

Allergy Rhinol (Providence). 2018 Jan-Dec;9:2152656718804905

Authors: Falls ME, Rabinowitz MP, Carrasco JR, Rabinowitz MR

Abstract
Background: Fraser syndrome is an autosomal recessive disorder characterized primarily by syndactyly, cryptophthalmos, urinary tract anomalies, ambiguous genitalia, and laryngeal anomalies. A 28-year-old man with Fraser syndrome presented with cryptophthalmos, microphthalmia, lacrimal system dysgenesis, and chronic sinusitis.
Objective: The patients' clinical condition and surgical treatment are described. A literature review was conducted, and articles relevant to the case are presented.
Methods: Case report.
Results: To our knowledge, this is the first published case report of endonasal management of dacryocystoceles in a Fraser syndrome patient. The patient was treated via endoscopic endonasal marsupialization and drainage.
Conclusion: Fraser syndrome patients may initially present to many different specialties as the spectrum of clinical manifestations is broad. Physicians treating these patients should take a collaborative approach to surgical and medical management.

PMID: 30364810 [PubMed]

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The Impact of Transitional Movements and Non-Manual Markings on the Disambiguation of Locally Ambiguous Argument Structures in Austrian Sign Language ( ÖGS).

The Impact of Transitional Movements and Non-Manual Markings on the Disambiguation of Locally Ambiguous Argument Structures in Austrian Sign Language (ÖGS). Lang Speech. 2018 Oct 24;:23830918801399 Authors: Krebs J, Wilbur RB, Alday PM, Roehm D Abstract Previous studies of Austrian Sign Language (ÖGS) word-order variations have demonstrated the human processing system's tendency to interpret a sentence-initial (case-) ambiguous argument as the subject of the clause ("subject preference"). The electroencephalogram study motivating the current report revealed earlier reanalysis effects for object-subject compared to subject-object sentences, in particular, before the start of the movement of the agreement marking sign. The effects were bound to time points prior to whe...

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A Phase 1/2a Study of PGT121 and VRC07-523LS Monoclonal Antibodies in HIV-uninfected and HIV-infected Adults

Condition:   HIV/AIDS Intervention:   Biological: PGT121 + VRC07-523LS Sponsors:   International AIDS Vaccine Initiative;   Beth Israel Deaconess Medical Center;   Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Not yet recruiting (Source: ClinicalTrials.gov)

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Perception of American-English Vowels by Early and Late Spanish-English Bilinguals.

Authors: Baigorri M, Campanelli L, Levy ES Abstract Increasing numbers of Hispanic immigrants are entering the US and learning American-English (AE) as a second language (L2). Previous studies investigating the relationship between AE and Spanish vowels have revealed an advantage for early L2 learners for their accuracy of L2 vowel perception. Replicating and extending such previous research, this study examined the patterns with which early and late Spanish-English bilingual adults assimilated naturally-produced AE vowels to their native vowel inventory and the accuracy with which they discriminated the vowels. Twelve early Spanish-English bilingual, 12 late Spanish-English bilingual, and 10 monolingual listeners performed perceptual-assimilation and categorical-discrimination tas...

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The Impact of Transitional Movements and Non-Manual Markings on the Disambiguation of Locally Ambiguous Argument Structures in Austrian Sign Language ( ÖGS).

The Impact of Transitional Movements and Non-Manual Markings on the Disambiguation of Locally Ambiguous Argument Structures in Austrian Sign Language (ÖGS). Lang Speech. 2018 Oct 24;:23830918801399 Authors: Krebs J, Wilbur RB, Alday PM, Roehm D Abstract Previous studies of Austrian Sign Language (ÖGS) word-order variations have demonstrated the human processing system's tendency to interpret a sentence-initial (case-) ambiguous argument as the subject of the clause ("subject preference"). The electroencephalogram study motivating the current report revealed earlier reanalysis effects for object-subject compared to subject-object sentences, in particular, before the start of the movement of the agreement marking sign. The effects were bound to time points prior to whe...

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Emotion Words Modulate Early Conflict Processing in a Flanker Task: Differentiating Emotion-Label Words and Emotion-Laden Words in Second Language.

Authors: Zhang J, Teo T, Wu C Abstract Emotion words modulate conflict processing, even at an early stage (i.e., N200). However, the previous studies implicitly mixed emotion-label words and emotion-laden words together and mostly concentrated on first language (L1) rather than on second language (L2). The current study aimed to investigate whether L2 negative emotion-label words, negative emotion-laden words, and neutral words would affect conflict processing in a flanker task by using event-related potential (ERP) measurements. Twenty Chinese-English bilinguals completed a modified flanker task to decide the color of the target words. The results revealed that only L2 negative emotion-label words elicited larger left frontal N200 in the incongruent condition than in the congruent...

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Transarterial embolization of peripheral high-flow arteriovenous malformation with ethylene vinyl alcohol copolymer (Onyx ® ): single-center 10-year experience

Abstract

Purpose

High-flow arteriovenous malformations (AVMs) are complex vascular lesions for which transcatheter embolization is considered as first-choice treatment nowadays. Multiple embolizing agents have been described, and among them, Onyx^® seems to be promising; this is a liquid embolic agent, originally applied in neurointerventional radiology and recently adopted also in peripheral embolizations. The aim of this study is to report on a 10-year experience of transarterial embolization of peripheral high-flow AVM with Onyx^® in terms of technical and clinical outcomes.

Materials and methods

Retrospective analysis was conducted on patients affected by high-flow AVM and treated electively by transarterial embolization with Onyx^®. Data collection included: preinterventional clinical radiological evaluations, procedural data and post-procedural clinical radiological assessment. Technical and clinical success was evaluated; follow-up was conducted 30 days after the last treatment session and yearly in case of success.

Results

Sixteen patients have been included, totally 38 embolizing procedures. Additional embolizing agents were required in 5 patients. Technical success was obtained in 11 patients; at 30-day follow-up, 15 patients showed improvements in symptoms, even those with incomplete embolization; however, after almost 1 year from treatment accomplishment, 7 patients showed relapse of symptoms and presented radiological signs of AVM recurrence. No clinically relevant complications occurred.

Conclusions

In this series, in accordance with previous but limited published data, Onyx^® appeared safe and technically effective to embolize high-flow peripheral AVM with transarterial approach. Clinical radiological follow-up is mandatory because new feeder recruitment has to be expected; patients should be informed of the concrete possibility of multiple treatment sessions.

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On the scaling behavior of water diffusion in human brain white matter

Publication date: 15 January 2019

Source: NeuroImage, Volume 185

Author(s): Jelle Veraart, Els Fieremans, Dmitry S. Novikov

Abstract

Development of therapies for neurological disorders depends on our ability to non-invasively diagnose and monitor the progression of underlying pathologies at the cellular level. Physics and physiology limit the resolution of human MRI to be orders of magnitude coarser than cell dimensions. Here we identify and quantify the MRI signal coming from within micrometer-thin axons in human white matter tracts in vivo, by utilizing the sensitivity of diffusion MRI to Brownian motion of water molecules restricted by cell walls. We study a specific power-law scaling of the diffusion MRI signal with the diffusion weighting, predicted for water confined to narrow axons, and quantify axonal water fraction and orientation dispersion.

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MDCT in acute ischaemic left colitis: a pictorial essay

Abstract

The pathogenesis of acute ischaemic colitis depends on two different forms of vascular colonic insult: occlusive injury and non-occlusive injury. Clinically, ischaemic colitis may be classified as two major forms: mild (non-gangrenous) and acute fulminant (gangrenous). The classic presentation is abdominal pain, diarrhoea and/or rectal bleeding, but it is not specific and highly variable and so the diagnosis usually depends on clinical suspicion and is supported by serologic and colonoscopic findings. Imaging methods have their role in diagnosing IC. While plain radiography and ultrasound can orient the diagnosis, CT allows to define the morphofunctional alterations discriminating the non-occlusive forms from the occlusive forms and in most cases to estimate the timing of ischaemic damage. Purpose of the review is to define the role of CT in the early identification of pathological findings and in the definition of evolution of colonic ischaemic lesions, in order to plan the correct therapeutic approach, suggesting the decision of medical or surgical treatment.

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On the scaling behavior of water diffusion in human brain white matter

Publication date: 15 January 2019

Source: NeuroImage, Volume 185

Author(s): Jelle Veraart, Els Fieremans, Dmitry S. Novikov

Abstract

Development of therapies for neurological disorders depends on our ability to non-invasively diagnose and monitor the progression of underlying pathologies at the cellular level. Physics and physiology limit the resolution of human MRI to be orders of magnitude coarser than cell dimensions. Here we identify and quantify the MRI signal coming from within micrometer-thin axons in human white matter tracts in vivo, by utilizing the sensitivity of diffusion MRI to Brownian motion of water molecules restricted by cell walls. We study a specific power-law scaling of the diffusion MRI signal with the diffusion weighting, predicted for water confined to narrow axons, and quantify axonal water fraction and orientation dispersion.

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V1 activity during feedforward and early feedback processing is necessary for both conscious and unconscious motion perception

Publication date: 15 January 2019

Source: NeuroImage, Volume 185

Author(s): Mikko Hurme, Mika Koivisto, Antti Revonsuo, Henry Railo

Abstract

The study of blindsight has revealed a seminal dissociation between conscious vision and visually guided behavior: some patients who are blind due to V1 lesions seem to be able to employ unconscious visual information in their behavior. The standard assumption is that these findings generalize to the neurologically healthy. We tested whether unconscious processing of motion is possible without the contribution of V1 in neurologically healthy participants by disturbing activity in V1 using transcranial magnetic stimulation (TMS). Unconscious processing was measured with redundant target effect (RTE), a phenomenon where participants respond faster to two stimuli than to one stimulus, when the task is just to respond as fast as possible when one stimulus or two simultaneous stimuli are presented. We measured the RTE caused by a motion stimulus. V1 activity was interfered with different stimulus onset asynchronies (SOA) to test whether TMS delivered in a specific time window suppresses conscious perception (participant reports seeing only one of the two stimuli) but does not affect unconscious processing (RTE). We observed that at each SOA, when TMS suppressed conscious perception of the stimulus, the RTE was also eliminated. However, when visibility of the redundant target was suppressed with a visual mask, we found unconscious processing of motion. This suggests that unconscious processing of motion depends on V1 in neurologically healthy humans. We conclude that the neural mechanisms that enable motion processing in blindsight are modulated by neuroplastic changes in connectivity between subcortical areas and the visual cortex after the V1 lesion. Neurologically healthy observers cannot process motion unconsciously without functioning of V1.

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MDCT in acute ischaemic left colitis: a pictorial essay

Abstract

The pathogenesis of acute ischaemic colitis depends on two different forms of vascular colonic insult: occlusive injury and non-occlusive injury. Clinically, ischaemic colitis may be classified as two major forms: mild (non-gangrenous) and acute fulminant (gangrenous). The classic presentation is abdominal pain, diarrhoea and/or rectal bleeding, but it is not specific and highly variable and so the diagnosis usually depends on clinical suspicion and is supported by serologic and colonoscopic findings. Imaging methods have their role in diagnosing IC. While plain radiography and ultrasound can orient the diagnosis, CT allows to define the morphofunctional alterations discriminating the non-occlusive forms from the occlusive forms and in most cases to estimate the timing of ischaemic damage. Purpose of the review is to define the role of CT in the early identification of pathological findings and in the definition of evolution of colonic ischaemic lesions, in order to plan the correct therapeutic approach, suggesting the decision of medical or surgical treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Jjs11P

Transarterial embolization of peripheral high-flow arteriovenous malformation with ethylene vinyl alcohol copolymer (Onyx ® ): single-center 10-year experience

Abstract

Purpose

High-flow arteriovenous malformations (AVMs) are complex vascular lesions for which transcatheter embolization is considered as first-choice treatment nowadays. Multiple embolizing agents have been described, and among them, Onyx^® seems to be promising; this is a liquid embolic agent, originally applied in neurointerventional radiology and recently adopted also in peripheral embolizations. The aim of this study is to report on a 10-year experience of transarterial embolization of peripheral high-flow AVM with Onyx^® in terms of technical and clinical outcomes.

Materials and methods

Retrospective analysis was conducted on patients affected by high-flow AVM and treated electively by transarterial embolization with Onyx^®. Data collection included: preinterventional clinical radiological evaluations, procedural data and post-procedural clinical radiological assessment. Technical and clinical success was evaluated; follow-up was conducted 30 days after the last treatment session and yearly in case of success.

Results

Sixteen patients have been included, totally 38 embolizing procedures. Additional embolizing agents were required in 5 patients. Technical success was obtained in 11 patients; at 30-day follow-up, 15 patients showed improvements in symptoms, even those with incomplete embolization; however, after almost 1 year from treatment accomplishment, 7 patients showed relapse of symptoms and presented radiological signs of AVM recurrence. No clinically relevant complications occurred.

Conclusions

In this series, in accordance with previous but limited published data, Onyx^® appeared safe and technically effective to embolize high-flow peripheral AVM with transarterial approach. Clinical radiological follow-up is mandatory because new feeder recruitment has to be expected; patients should be informed of the concrete possibility of multiple treatment sessions.

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Associations of unsafe, unsupportive and underdeveloped neighborhoods with atopic dermatitis in US children

Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 12.97% of US children1 and 7% of US adults.2 Emotional factors, e.g. anxiety and stress, can also exacerbate AD flares and influence the course of disease.3,4 AD also poses a significant financial burden on society and negatively impacts patient and family quality of life.5,6 However, the relationship between childhood AD and neighborhood conditions has yet to be examined. (Source: Annals of Allergy, Asthma and Immunology)

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Window Studies in Squamous Cell Carcinoma of the Head and Neck: Values and Limits

Opinion statementIn head and neck cancer, we continue to work towards a more personalized approach to treatment of patients, where analysis of a patient 's tumor guides targeting of molecular or immunologic pathways. Critically important to this pursuit is a better understanding of the direct biologic effect of a drug or combination on the tumor microenvironment in humans, as well as biomarker discovery. These goals are consistent with the primary purpose of a "window of opportunity" trial and while conduct of these trials requires a careful balance of benefits and potential risks, to date these trials have been both feasible and safe in HNSCC in the curative intent setting. In the era of immunotherapy, with countless possible combinatio ns and ongoing clinical trials, window trials ...

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Window Studies in Squamous Cell Carcinoma of the Head and Neck: Values and Limits

Opinion statementIn head and neck cancer, we continue to work towards a more personalized approach to treatment of patients, where analysis of a patient 's tumor guides targeting of molecular or immunologic pathways. Critically important to this pursuit is a better understanding of the direct biologic effect of a drug or combination on the tumor microenvironment in humans, as well as biomarker discovery. These goals are consistent with the primary purpose of a "window of opportunity" trial and while conduct of these trials requires a careful balance of benefits and potential risks, to date these trials have been both feasible and safe in HNSCC in the curative intent setting. In the era of immunotherapy, with countless possible combinatio ns and ongoing clinical trials, window trials ...

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Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients

The inability to resolve Coccidioides infection correlates with elevated Treg frequency and functional marker expression at diagnosis. Treg frequency may be a diagnostic for calibrating treatment aggressiveness for patients likely to develop chronic cocciodiomycosis. (Source: Journal of Allergy and Clinical Immunology)

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The 2018 Nobel Prize in Physiology or Medicine: An exemplar of Bench to Bedside in Immunology

(Source: Journal of Allergy and Clinical Immunology)

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The 2018 Nobel Prize in Physiology or Medicine: An exemplar of Bench to Bedside in Immunology

(Source: Journal of Allergy and Clinical Immunology)

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Co-existent TBX1 Mutation and Chromosomal 20q13.13-q13.2 Duplication in an Infant with Abnormal TREC Newborn Screening

An eight day old male, term infant of a diabetic mother with patent ductus arteriosus was transferred from an outlying facility for surgical management of truncus arteriosus (TA), coarctation of the aorta, hypoplastic aortic arch, and anomalous origin of the right subclavian artery. The newborn also had absent thymic shadow on chest radiograph, hypocalcemia, and abnormal newborn screening (NBS) for severe combined immunodeficiency (SCID) measuring T cell receptor rearrangement circles (TRECs); threshold cycle (Ct) was 36.86 (Normal (Source: Annals of Allergy, Asthma and Immunology)

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Associations of unsafe, unsupportive and underdeveloped neighborhoods with atopic dermatitis in US children

Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 12.97% of US children1 and 7% of US adults.2 Emotional factors, e.g. anxiety and stress, can also exacerbate AD flares and influence the course of disease.3,4 AD also poses a significant financial burden on society and negatively impacts patient and family quality of life.5,6 However, the relationship between childhood AD and neighborhood conditions has yet to be examined. (Source: Annals of Allergy, Asthma and Immunology)

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Progestogen Hypersensitivity: presentation and natural history

To review the published medical literature on the clinical presentation, risk factors, and natural history of hypersensitivity reactions to progestogens. (Source: Annals of Allergy, Asthma and Immunology)

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Progestogen Hypersensitivity: presentation and natural history

To review the published medical literature on the clinical presentation, risk factors, and natural history of hypersensitivity reactions to progestogens. (Source: Annals of Allergy, Asthma and Immunology)

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Mayo Clinic Minute: How to keep kids with food allergies safe during Halloween

Halloween can be a particularly difficult time for kids with food allergies since many common candies contain one or more common allergens. The consequences can be dangerous and traumatic for kids who accidentally consume something they're allergic to. But a growing movement to give kids with food allergies some non-food treat options is making things [...] (Source: News from Mayo Clinic)

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The synergistic effect of NOD2 and TLR4 on the activation of autophagy in human submandibular gland inflammation

Journal of Oral Pathology &Medicine, Volume 0, Issue ja, -Not available-.


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Mayo Clinic Minute: How to keep kids with food allergies safe during Halloween

Halloween can be a particularly difficult time for kids with food allergies since many common candies contain one or more common allergens. The consequences can be dangerous and traumatic for kids who accidentally consume something they're allergic to. But a growing movement to give kids with food allergies some non-food treat options is making things [...] (Source: News from Mayo Clinic)

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Mayo Clinic Minute: How to keep kids with food allergies safe during Halloween

Halloween can be a particularly difficult time for kids with food allergies since many common candies contain one or more common allergens. The consequences can be dangerous and traumatic for kids who accidentally consume something they're allergic to. But a growing movement to give kids with food allergies some non-food treat options is making things [...] (Source: News from Mayo Clinic)

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Mayo Clinic Minute: How to keep kids with food allergies safe during Halloween

Halloween can be a particularly difficult time for kids with food allergies since many common candies contain one or more common allergens. The consequences can be dangerous and traumatic for kids who accidentally consume something they're allergic to. But a growing movement to give kids with food allergies some non-food treat options is making things [...] (Source: News from Mayo Clinic)

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Fixed airflow obstruction relates to eosinophil activation in asthmatics

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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Fixed airflow obstruction relates to eosinophil activation in asthmatics

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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Orthognathic surgery induces genome‐wide changes longitudinally in DNA methylation in saliva

Oral Diseases, Volume 0, Issue ja, -Not available-.


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Orthognathic surgery induces genome‐wide changes longitudinally in DNA methylation in saliva

Oral Diseases, Volume 0, Issue ja, -Not available-.


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18 F-FDG PET/CT detects Metastatic Renal Cell Carcinoma Masquerading as Primary Breast Malignancy

Abstract

We present the case of a 36-year-old woman who underwent ¹⁸F-FDG PET/CT with suspicion of a primary breast malignancy. However, PET/CT detected an occult renal cell carcinoma with metastases to the thyroid, breast, lungs and lymph nodes. Thyroid and breast metastases are atypical metastatic sites of renal cell carcinoma. Breast metastases from extra mammary tissue are extremely rare, more so from renal cell carcinoma. Histopathologic confirmation of the breast lesions is imperative to avoid unnecessary mastectomy and imaging can help in raising the suspicion of metastatic involvement versus primary breast malignancy.

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Letter to the Editor in reference to: Expression of 15‐lipoxygenase‐1 in Merkel cell carcinoma is linked to advanced disease

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


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Reducing observation time in children post‐adenoidectomy

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


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Letter to the Editor in reference to: Expression of 15‐lipoxygenase‐1 in Merkel cell carcinoma is linked to advanced disease

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


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Reducing observation time in children post‐adenoidectomy

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


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Osteopontin protects against pneumococcal infection in a murine model of allergic airway inflammation

Allergy, Volume 0, Issue ja, -Not available-.


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Osteopontin protects against pneumococcal infection in a murine model of allergic airway inflammation

Allergy, Volume 0, Issue ja, -Not available-.


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The hippo pathway effector YAP promotes epithelial proliferation and remodeling in chronic rhinosinusitis with nasal polyps

Allergy, Volume 0, Issue ja, -Not available-.


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Clustering analysis in outpatients with allergic rhinitis in clinical practice

Allergy, Volume 0, Issue ja, -Not available-.


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Clustering analysis in outpatients with allergic rhinitis in clinical practice

Allergy, Volume 0, Issue ja, -Not available-.


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MR‐Based Radiomics Nomogram of Cervical Cancer in Prediction of the Lymph‐Vascular Space Invasion preoperatively

Journal of Magnetic Resonance Imaging, EarlyView.


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MR‐Based Radiomics Nomogram of Cervical Cancer in Prediction of the Lymph‐Vascular Space Invasion preoperatively

Journal of Magnetic Resonance Imaging, EarlyView.


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Acknowledgment of Reviewers 2016 and 2017

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Acknowledgment of Reviewers 2016 and 2017

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Speech Understanding and Sound Localization with a New Nonimplantable Wearing Option for Baha.

Conclusions: Bone conduction sound processor mounted on a SoundArc or on a softband resulted in considerable improvements in hearing and speech understanding in subjects with a simulated, purely conductive, and bilateral hearing loss. No significant difference between the 2 wearing options was found. Using 2 sound processors improves sound localization and speech understanding in noise in certain spatial settings. PMID: 30356363 [PubMed - in process] (Source: Biomed Res)

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Development of Phonological, Lexical, and Syntactic Abilities in Children With Cochlear Implants Across the Elementary Grades

Conclusions Congenital hearing loss puts children at continued risk of language deficits, especially for phonologically based skills. Two interventions that appear to ameliorate that risk are providing a period of bimodal stimulation and strong literacy instruction. (Source: Journal of Speech, Language, and Hearing Research)

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Speech Understanding and Sound Localization with a New Nonimplantable Wearing Option for Baha.

Conclusions: Bone conduction sound processor mounted on a SoundArc or on a softband resulted in considerable improvements in hearing and speech understanding in subjects with a simulated, purely conductive, and bilateral hearing loss. No significant difference between the 2 wearing options was found. Using 2 sound processors improves sound localization and speech understanding in noise in certain spatial settings. PMID: 30356363 [PubMed - in process] (Source: Biomed Res)

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