Malaria Systems Immunology: Plasmodium vivax induces tolerance during primary infection through dysregulation of neutrophils and dendritic cells

Malaria remains an important public health problem worldwide, with more than 216 million cases per year 445,000 deaths.1 The cyclical fever and pro-inflammatory state associated with malaria has been postulated to inhibit establishment and maintenance of immunological memory 2; indeed, humoral and cellular responses to Plasmodium antigens are inefficiently generated and rapidly lost in the absence of ongoing exposure. As a result, individuals from high malaria transmission areas develop partial protection against severe symptoms at an early age and experience a significant number of asymptomatic infections afterwards. (Source: Journal of Infection)

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