The burden of depression in systemic sclerosis patients: insights from a real-world big data-based analysis

Systemic sclerosis (SSc) is an autoimmune connective-tissue disorder characterized by micro-vascular damage, immunologic impairments and tissue fibrosis, due to a massive deposition of collagen and other matrix substances within the skin and internal organs (Elhai et al., 2015). According to a large, population-wide assessment of two claim databases, in the USA, SSc has a prevalence of 0.05% (Robinson et al., 2008). Immune-mediated inflammatory diseases including SSc have a substantial societal burden, owing to the impacts of chronicity, acute exacerbations and progressive disability (Enns et al., 2018). (Source: Journal of Affective Disorders)

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