Isolation and characterization of ovine monocyte-derived macrophages from peripheral blood

Publication date: Available online 3 November 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Yongxiao Liu, Dongbing Yang, Shao Wei, Yijuan Nie, Xiaosheng Zhang, Zhengxing Lian, Hongbing HanAbstractAs key elements and targets for various intracellular pathogens, macrophages play an essential role in host defense. Although sheep peripheral blood monocyte-derived cell lines have been established, their phenotypic characteristics and functional properties remain unknown. We have established several sheep macrophage cell lines from peripheral blood adherent cells that can proliferate spontaneously in long-term culture in vitro. Macrophages characteristics were shaped by cell morphology, cell adhesion, expression of cell surface markers, phagocytic activity and inflammatory resp...

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