Microbiome modulates intestinal homeostasis against inflammatory diseases

Publication date: Available online 3 November 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Xiaolun Sun, Zhenquan JiaAbstractEliminating prophylactic antibiotics in food animal production has exerted pressure on discovering antimicrobial alternatives (e.g. microbiome) to reduce elevated intestinal diseases. Intestinal tract is a complex ecosystem coupling host cells with microbiota. The microbiota and its metabolic activities and products are collectively called microbiome. Intestinal homeostasis is reached through dynamic and delicate crosstalk between host immunity and microbiome. However, this balance can be occasionally broken, which results in intestinal inflammatory diseases such as human Inflammatory Bowel Diseases, chicken necrotic enteritis, and swine postweaning...

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