Obesity and dysregulated central and peripheral macrophage –neuron cross‐talk

Macrophages are central players in obesity ‐associated chronic low‐grade inflammation. Moreover, recent studies revealed an intriguing tri‐partite, neuronal–macrophage–adipocyte cross‐talk, involving norepinephrine (NE) in the white and brown adipose tissues (WAT; BAT) as well as a prominent role for microglia in the diet‐induc ed CNS inflammation. AbstractThe involvement of macrophages in the pathogenesis of obesity has been recognized since 2003. Early studies mostly focused on the role of macrophages in adipose tissue (AT) and in obesity ‐associated chronic low‐grade inflammation. Lately, AT macrophages were shown to undergo intrinsic metabolic changes that affect their immune function (i.e., immunometabolism), corresponding to their unique properties along the range o...

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