Purpose of review The perioperative outcome in obstructive sleep apnea (OSA) patients undergoing ambulatory surgery can be potentially impacted by the type of anesthetic technique, fluid management and choice of anesthetic agents. This review highlights the best perioperative practices in the management of OSA patients undergoing ambulatory surgical procedures. Recent findings A recent meta-analysis found that STOP-Bang might be used as a perioperative risk stratification tool. Patients with high-risk OSA (STOP-Bang ≥3) were found to be associated with an increased risk of postoperative complications and prolonged length of hospital stay compared with low-risk OSA (STOP-Bang 0-2) patients undergoing noncardiac surgical procedures. A bidirectional relationship exists between OSA and difficult airway. Both suspected or diagnosed OSA may be associated with either difficult intubation or difficult mask ventilation or both. A recent meta-analysis identified OSA as an important risk factor for opioid-induced respiratory depression. A dose–response relationship was shown between the morphine equivalent daily dose and death or near-death events in OSA patients undergoing surgery. Postoperative continuous monitoring is recommended for high-risk OSA patients receiving opioids. Minimising the dose of muscle relaxant, neuromuscular monitoring and ensuring complete reversal of neuromuscular blockade before extubation is essential in OSA patients to avoid postoperative complications. Whenever feasible, regional anesthesia with multimodal analgesia may be considered as a better alternative to general anesthesia in OSA patients. Summary Patients with OSA and associated comorbidities present a challenge to anesthesiologists as they are at a high risk of perioperative complications. It is important to identify patients with OSA, with the goal to raise awareness among providers, mitigate risk and improve outcomes. Correspondence to Frances Chung, Professor, Department of Anesthesia, Toronto Western Hospital, University Health Network, 399 Bathurst Street, MCL 2-405, Toronto, ON M5T 2S8, Canada. E-mail: Frances.chung@uhn.ca Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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Κυριακή 9 Σεπτεμβρίου 2018
Best perioperative practice in management of ambulatory patients with obstructive sleep apnea
Purpose of review The perioperative outcome in obstructive sleep apnea (OSA) patients undergoing ambulatory surgery can be potentially impacted by the type of anesthetic technique, fluid management and choice of anesthetic agents. This review highlights the best perioperative practices in the management of OSA patients undergoing ambulatory surgical procedures. Recent findings A recent meta-analysis found that STOP-Bang might be used as a perioperative risk stratification tool. Patients with high-risk OSA (STOP-Bang ≥3) were found to be associated with an increased risk of postoperative complications and prolonged length of hospital stay compared with low-risk OSA (STOP-Bang 0-2) patients undergoing noncardiac surgical procedures. A bidirectional relationship exists between OSA and difficult airway. Both suspected or diagnosed OSA may be associated with either difficult intubation or difficult mask ventilation or both. A recent meta-analysis identified OSA as an important risk factor for opioid-induced respiratory depression. A dose–response relationship was shown between the morphine equivalent daily dose and death or near-death events in OSA patients undergoing surgery. Postoperative continuous monitoring is recommended for high-risk OSA patients receiving opioids. Minimising the dose of muscle relaxant, neuromuscular monitoring and ensuring complete reversal of neuromuscular blockade before extubation is essential in OSA patients to avoid postoperative complications. Whenever feasible, regional anesthesia with multimodal analgesia may be considered as a better alternative to general anesthesia in OSA patients. Summary Patients with OSA and associated comorbidities present a challenge to anesthesiologists as they are at a high risk of perioperative complications. It is important to identify patients with OSA, with the goal to raise awareness among providers, mitigate risk and improve outcomes. Correspondence to Frances Chung, Professor, Department of Anesthesia, Toronto Western Hospital, University Health Network, 399 Bathurst Street, MCL 2-405, Toronto, ON M5T 2S8, Canada. E-mail: Frances.chung@uhn.ca Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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Evaluation of Intra‐ and Interscanner Reliability of MRI Protocols for Spinal Cord Gray Matter and Total Cross‐Sectional Area Measurements
Journal of Magnetic Resonance Imaging, EarlyView.
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Evaluation of Intra‐ and Interscanner Reliability of MRI Protocols for Spinal Cord Gray Matter and Total Cross‐Sectional Area Measurements
Journal of Magnetic Resonance Imaging, EarlyView.
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Icariin and icaritin recover UVB-induced photoaging by stimulating Nrf2/ARE and reducing AP-1 and NF-κB signaling pathways; A comparative study on UVB-irradiated human keratinocytes
Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00174J, Paper
DOI: 10.1039/C8PP00174J, Paper
Eunson Hwang, Pei Lin, Hien T. T. Ngo, Wei Gao, Yu-Shuai Wang, Hong-Shan Yu, Tae Hoo Yi
Icariin (ICA) and icaritin (ICT) possess many pharmacological functions including anti-osteoporosis, anti-cardiovascular, and anti-cancer; however, there are few comprehensive studies track the detailed effects on UVB-induced photoaging. The recovery effects...
The content of this RSS Feed (c) The Royal Society of Chemistry
Icariin (ICA) and icaritin (ICT) possess many pharmacological functions including anti-osteoporosis, anti-cardiovascular, and anti-cancer; however, there are few comprehensive studies track the detailed effects on UVB-induced photoaging. The recovery effects...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Icariin and icaritin recover UVB-induced photoaging by stimulating Nrf2/ARE and reducing AP-1 and NF-κB signaling pathways; A comparative study on UVB-irradiated human keratinocytes
Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00174J, Paper
DOI: 10.1039/C8PP00174J, Paper
Eunson Hwang, Pei Lin, Hien T. T. Ngo, Wei Gao, Yu-Shuai Wang, Hong-Shan Yu, Tae Hoo Yi
Icariin (ICA) and icaritin (ICT) possess many pharmacological functions including anti-osteoporosis, anti-cardiovascular, and anti-cancer; however, there are few comprehensive studies track the detailed effects on UVB-induced photoaging. The recovery effects...
The content of this RSS Feed (c) The Royal Society of Chemistry
Icariin (ICA) and icaritin (ICT) possess many pharmacological functions including anti-osteoporosis, anti-cardiovascular, and anti-cancer; however, there are few comprehensive studies track the detailed effects on UVB-induced photoaging. The recovery effects...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Family helps Cancer Assistance of Williams County
| Family helps Cancer Assistance of Williams County The Bryan TimesFull coverage |
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Family helps Cancer Assistance of Williams County
| Family helps Cancer Assistance of Williams County The Bryan TimesFull coverage |
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Needs unique for young adult cancer patients
| Needs unique for young adult cancer patients Fort Wayne Journal GazetteFull coverage |
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Needs unique for young adult cancer patients
| Needs unique for young adult cancer patients Fort Wayne Journal GazetteFull coverage |
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Pediatric Otolaryngological Emergency: An Experience from a Tertiary Care Teaching Institution at Kolkata, India
Abstract
Otolaryngological conditions constitute a major share of emergency medical problem among children. The present study was conducted to assess the patient profiles, incidences morbidities, mode of presentation and managements of different otolaryngological emergencies among pediatric patients presented in a tertiary care hospital. Descriptive cross-sectional study by analysing retrospectively collected information pertaining to the patients attended ENT emergency service department of a tertiary care hospital, Kolkata. Data were collected using predesigned proforma and were analysed with the help of SPSS version 20. About 39.0% of total ENT emergency attendance was contributed by pediatric age group. The male female ratio was 1:1.33 with average age of 58.95 ± 34.42 (mean ± SD) months. Half of the attendees had ear problem and almost one-third reported complaints related to nose. The major complaints at the time of presentation were earache (32.3%), nasal foreign body (24.0%) and aural foreign body (13.3%) closely followed by aero-digestive tract foreign body (12.0%). Inflammatory conditions affected the ears more, foreign bodies found most commonly in nose and miscellaneous condition such as impacted wax was found to be related to ear in significantly higher proportion. Conservative management was provided to 96.25% of patients. Foreign body insertion was found to be associated with lower age group. Most of the emergencies were managed conservatively which might be done at subdivision or district level to reduce the undesirable burden on the tertiary care medical colleges.
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Ossifying Fibroma of Maxilla in a Female Affected by Neurofibromatosis Type 1
Abstract
Ossifying fibroma is a benign fibro-osseous lesion found exclusively in jaws. It has a predilection for premolar–molar region in the mandible. The occurrence of OF as solitary lesions with no underlying disease is common in jaws. However its co-existence in patients with neurofibromatosis type 1 (NF1) has not been described in jaws. NF1, also known as von Recklinghausen's disease or peripheral neurofibromatosis, is an autosomal dominant multisystem disorder that approximately affects 1 in 2500–3000 births. The common manifestations of this disease include Café-au-lait macules, skinfold freckling, cutaneous neurofibromas, blue-red and pseudoatrophic macules on skin, plexiform neurofibroma, scoliosis, optic glioma. So far only one case of ossifying fibroma (OF) in such patients has been reported in the skull but not in the maxillofacial region. We report a case of OF of the maxilla in a 45 year old female suffering from NF1. To the best of our knowledge this is the first case report where OF occurred in the maxilla in patient with NF1.
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Ahila’s Diathermy Round Knife for Endoscopic Ear Surgery
Abstract
As endoscopic ear surgery is evolving day by day there is a constant need for improvisation in terms of instrumentation, visualization and clear bloodless surgical field. The applications of Ahila's Diathermy Round Knife for Endoscopic Ear Surgery are presented. The development of Ahila's diathermy round knife will prevent shifting to two handed ear surgery or the need for Endo holders. This new instrument is a game changer in endoscopic ear surgery creating a clean incision and bloodless field to operate. Surgical Instruments represent a major financial asset to the healthcare facility. Careful attention to care, handling and sterilization is essential to avoid costly replacements, enhance patient and surgeon satisfaction, reduce costs and delays in the Operating room and enhance patient safety. Ahila's round diathermy knife may facilitate the performance of surgery and advance the art of Endoscopic surgery to a higher level.
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Cystic Myoepithelioma of Parapharyngeal Space
Abstract
Myoepitheliomas are rare tumours of salivary glands arising from myoepithelial cells, which are normal constituent of the salivary acini and ducts and are found between the epithelial cells and the basement membrane. The most common site of origin of Myoepitheliomas are the salivary glands and rarely other sites in the head and neck have been described in literature. Myoepithelioma arising from parapharyngeal space provide both a diagnostic and therapeutic challenge. We present such a case and discuss its diagnostic and therapeutic aspects.
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Pediatric Otolaryngological Emergency: An Experience from a Tertiary Care Teaching Institution at Kolkata, India
Abstract
Otolaryngological conditions constitute a major share of emergency medical problem among children. The present study was conducted to assess the patient profiles, incidences morbidities, mode of presentation and managements of different otolaryngological emergencies among pediatric patients presented in a tertiary care hospital. Descriptive cross-sectional study by analysing retrospectively collected information pertaining to the patients attended ENT emergency service department of a tertiary care hospital, Kolkata. Data were collected using predesigned proforma and were analysed with the help of SPSS version 20. About 39.0% of total ENT emergency attendance was contributed by pediatric age group. The male female ratio was 1:1.33 with average age of 58.95 ± 34.42 (mean ± SD) months. Half of the attendees had ear problem and almost one-third reported complaints related to nose. The major complaints at the time of presentation were earache (32.3%), nasal foreign body (24.0%) and aural foreign body (13.3%) closely followed by aero-digestive tract foreign body (12.0%). Inflammatory conditions affected the ears more, foreign bodies found most commonly in nose and miscellaneous condition such as impacted wax was found to be related to ear in significantly higher proportion. Conservative management was provided to 96.25% of patients. Foreign body insertion was found to be associated with lower age group. Most of the emergencies were managed conservatively which might be done at subdivision or district level to reduce the undesirable burden on the tertiary care medical colleges.
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Ossifying Fibroma of Maxilla in a Female Affected by Neurofibromatosis Type 1
Abstract
Ossifying fibroma is a benign fibro-osseous lesion found exclusively in jaws. It has a predilection for premolar–molar region in the mandible. The occurrence of OF as solitary lesions with no underlying disease is common in jaws. However its co-existence in patients with neurofibromatosis type 1 (NF1) has not been described in jaws. NF1, also known as von Recklinghausen's disease or peripheral neurofibromatosis, is an autosomal dominant multisystem disorder that approximately affects 1 in 2500–3000 births. The common manifestations of this disease include Café-au-lait macules, skinfold freckling, cutaneous neurofibromas, blue-red and pseudoatrophic macules on skin, plexiform neurofibroma, scoliosis, optic glioma. So far only one case of ossifying fibroma (OF) in such patients has been reported in the skull but not in the maxillofacial region. We report a case of OF of the maxilla in a 45 year old female suffering from NF1. To the best of our knowledge this is the first case report where OF occurred in the maxilla in patient with NF1.
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Ahila’s Diathermy Round Knife for Endoscopic Ear Surgery
Abstract
As endoscopic ear surgery is evolving day by day there is a constant need for improvisation in terms of instrumentation, visualization and clear bloodless surgical field. The applications of Ahila's Diathermy Round Knife for Endoscopic Ear Surgery are presented. The development of Ahila's diathermy round knife will prevent shifting to two handed ear surgery or the need for Endo holders. This new instrument is a game changer in endoscopic ear surgery creating a clean incision and bloodless field to operate. Surgical Instruments represent a major financial asset to the healthcare facility. Careful attention to care, handling and sterilization is essential to avoid costly replacements, enhance patient and surgeon satisfaction, reduce costs and delays in the Operating room and enhance patient safety. Ahila's round diathermy knife may facilitate the performance of surgery and advance the art of Endoscopic surgery to a higher level.
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Cystic Myoepithelioma of Parapharyngeal Space
Abstract
Myoepitheliomas are rare tumours of salivary glands arising from myoepithelial cells, which are normal constituent of the salivary acini and ducts and are found between the epithelial cells and the basement membrane. The most common site of origin of Myoepitheliomas are the salivary glands and rarely other sites in the head and neck have been described in literature. Myoepithelioma arising from parapharyngeal space provide both a diagnostic and therapeutic challenge. We present such a case and discuss its diagnostic and therapeutic aspects.
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Nigeria: Lagos Govt Warns Against Use of Asbestos in Homes
| Nigeria: Lagos Govt Warns Against Use of Asbestos in Homes AllAfrica.comFull coverage |
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Nigeria: Lagos Govt Warns Against Use of Asbestos in Homes
| Nigeria: Lagos Govt Warns Against Use of Asbestos in Homes AllAfrica.comFull coverage |
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A multi-stakeholder perspective on asthma care in Canada: findings from a mixed methods needs assessment in the treatment and management of asthma in adults
Although several aspects of asthma care have been identified as being sub-optimal in Canada, such as patient education, practice guideline adoption, and access to care, there remains a need to determine the ex...
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A multi-stakeholder perspective on asthma care in Canada: findings from a mixed methods needs assessment in the treatment and management of asthma in adults
Although several aspects of asthma care have been identified as being sub-optimal in Canada, such as patient education, practice guideline adoption, and access to care, there remains a need to determine the ex...
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A multi-stakeholder perspective on asthma care in Canada: findings from a mixed methods needs assessment in the treatment and management of asthma in adults
Abstract
Background
Although several aspects of asthma care have been identified as being sub-optimal in Canada, such as patient education, practice guideline adoption, and access to care, there remains a need to determine the extent to which these gaps remain, so as to investigate their underlying causes, and potential solutions.
Methods
An ethics-approved mixed methods educational needs assessment was conducted in four Canadian provinces (Alberta, British Columbia, Ontario, and Quebec), combining a qualitative phase (45-min semi-structured interviews with community-based healthcare providers and key stakeholders) and a quantitative phase (15-min survey, healthcare providers only).
Results
A total of 234 participants were included in the study, 44 in semi-structured interviews and 190 in the online survey. Five clinical areas were reported to be suboptimal by multiple categories of participants, and specific causes were identified for each. These areas included: Integration of guidelines into clinical practice, use of spirometry, individualisation of asthma devices to patient needs, emphasis on patient adherence and self-management, and clarity regarding roles and responsibilities of different members of the asthma healthcare team. Common causes for gaps in all these areas included suboptimal knowledge amongst healthcare providers, differing perceptions on the importance of certain interventions, and inadequate communication between healthcare providers.
Conclusions
This study provides a better understanding of the specific causes underlying common gaps and challenges in asthma care in Canada. This information can inform future continuing medical education, and help providers in community settings obtain access to adequate materials, resources, and training to support optimal care of adult patients with asthma.
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A multi-stakeholder perspective on asthma care in Canada: findings from a mixed methods needs assessment in the treatment and management of asthma in adults
Abstract
Background
Although several aspects of asthma care have been identified as being sub-optimal in Canada, such as patient education, practice guideline adoption, and access to care, there remains a need to determine the extent to which these gaps remain, so as to investigate their underlying causes, and potential solutions.
Methods
An ethics-approved mixed methods educational needs assessment was conducted in four Canadian provinces (Alberta, British Columbia, Ontario, and Quebec), combining a qualitative phase (45-min semi-structured interviews with community-based healthcare providers and key stakeholders) and a quantitative phase (15-min survey, healthcare providers only).
Results
A total of 234 participants were included in the study, 44 in semi-structured interviews and 190 in the online survey. Five clinical areas were reported to be suboptimal by multiple categories of participants, and specific causes were identified for each. These areas included: Integration of guidelines into clinical practice, use of spirometry, individualisation of asthma devices to patient needs, emphasis on patient adherence and self-management, and clarity regarding roles and responsibilities of different members of the asthma healthcare team. Common causes for gaps in all these areas included suboptimal knowledge amongst healthcare providers, differing perceptions on the importance of certain interventions, and inadequate communication between healthcare providers.
Conclusions
This study provides a better understanding of the specific causes underlying common gaps and challenges in asthma care in Canada. This information can inform future continuing medical education, and help providers in community settings obtain access to adequate materials, resources, and training to support optimal care of adult patients with asthma.
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Is there an overlap in immune response between allergic bronchopulmonary and chronic pulmonary aspergillosis?
ConclusionsAbout 5% of subjects with CPA fulfilled all the immunological criteria used for diagnosing ABPA while 22% met the obligatory criteria for ABPA. Whether these patients would require a different management protocol requires further investigation. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing
Publication date: Available online 8 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Timothy J. Watts, David Thursfield, Rubaiyat Haque (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Oral vaccine based on a surface immunogenic protein mixed with alum promotes a decrease in Streptococcus agalactiae vaginal colonization in a mouse model
In this study, we show the immune response induced by an oral SIP-based vaccine formulated on alum in a mouse model. Our vaccine can reduce vaginal GBS colonization and induce specific SIP-antibodies with opsonophagocytosis activities against GBS. Moreover, we observed the activation of T-cells producing IFN-γ, TNF-α, IL-10, IL-2, and increased expression of the transcription factor T-bet, suggesting a Th1-type humoral response. The oral SIP-based vaccine is a novel alternative in the development of a vaccine against GBS. (Source: Molecular Immunology)
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Is there an overlap in immune response between allergic bronchopulmonary and chronic pulmonary aspergillosis?
ConclusionsAbout 5% of subjects with CPA fulfilled all the immunological criteria used for diagnosing ABPA while 22% met the obligatory criteria for ABPA. Whether these patients would require a different management protocol requires further investigation. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing
Publication date: Available online 8 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Timothy J. Watts, David Thursfield, Rubaiyat Haque (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Oral vaccine based on a surface immunogenic protein mixed with alum promotes a decrease in Streptococcus agalactiae vaginal colonization in a mouse model
In this study, we show the immune response induced by an oral SIP-based vaccine formulated on alum in a mouse model. Our vaccine can reduce vaginal GBS colonization and induce specific SIP-antibodies with opsonophagocytosis activities against GBS. Moreover, we observed the activation of T-cells producing IFN-γ, TNF-α, IL-10, IL-2, and increased expression of the transcription factor T-bet, suggesting a Th1-type humoral response. The oral SIP-based vaccine is a novel alternative in the development of a vaccine against GBS. (Source: Molecular Immunology)
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MicroRNA-300 suppresses metastasis of oral squamous cell carcinoma by inhibiting epithelial-to-mesenchymal transition
| MicroRNA-300 suppresses metastasis of oral squamous cell carcinoma by inhibiting epithelial-to-mesenchymal transition Dove Medical PressFull coverage |
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Podoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients
| Podoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients Dove Medical PressFull coverage |
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Why The Cancer Death Of A Fukushima Worker Was Likely Not Due To Fukushima
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MicroRNA-300 suppresses metastasis of oral squamous cell carcinoma by inhibiting epithelial-to-mesenchymal transition
| MicroRNA-300 suppresses metastasis of oral squamous cell carcinoma by inhibiting epithelial-to-mesenchymal transition Dove Medical PressFull coverage |
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Podoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients
| Podoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients Dove Medical PressFull coverage |
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Why The Cancer Death Of A Fukushima Worker Was Likely Not Due To Fukushima
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For new cancer treatments, less is more
| For new cancer treatments, less is more Washington PostFull coverage |
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For new cancer treatments, less is more
| For new cancer treatments, less is more Washington PostFull coverage |
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Characteristics of diffusion-weighted images and apparent diffusion coefficients of ranulas and other masses in and around the floor of the mouth
To evaluate the characteristics of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values of ranulas. In addition, to elucidate DWI findings and ADC values of other representative masses in and around the floor of the mouth.
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Characteristics of diffusion-weighted images and apparent diffusion coefficients of ranulas and other masses in and around the floor of the mouth
To evaluate the characteristics of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values of ranulas. In addition, to elucidate DWI findings and ADC values of other representative masses in and around the floor of the mouth.
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Gadi Singer interview — How Intel designs processors in the AI era
| Gadi Singer interview — How Intel designs processors in the AI era VentureBeatFull coverage |
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Gadi Singer interview — How Intel designs processors in the AI era
| Gadi Singer interview — How Intel designs processors in the AI era VentureBeatFull coverage |
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Painful Oral Lesions.
Authors: Hargitai IA Abstract Painful oral vesiculoerosive diseases (OVD) include lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, erythema multiforme, and recurrent aphthous stomatitis. OVD lesions have an immunopathic cause. Treatment is aimed at reducing the immunologic and the following inflammatory response. The mainstay of OVD management is topical or systemic corticosteroids to include topical triamcinolone, fluocinonide, and clobetasol, whereas systemic medications used in practice can include dexamethasone, prednisone, and prednisolone. Oral herpetic lesions can be primary or recurrent. If management is desired, they can be treated by topical or systemic antiviral drugs. Topical antiviral creams include prescription acyclovir, penciclovir and over-the-counter...
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Painful Oral Lesions.
Authors: Hargitai IA Abstract Painful oral vesiculoerosive diseases (OVD) include lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, erythema multiforme, and recurrent aphthous stomatitis. OVD lesions have an immunopathic cause. Treatment is aimed at reducing the immunologic and the following inflammatory response. The mainstay of OVD management is topical or systemic corticosteroids to include topical triamcinolone, fluocinonide, and clobetasol, whereas systemic medications used in practice can include dexamethasone, prednisone, and prednisolone. Oral herpetic lesions can be primary or recurrent. If management is desired, they can be treated by topical or systemic antiviral drugs. Topical antiviral creams include prescription acyclovir, penciclovir and over-the-counter...
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Biofloc technology (BFT): An alternative aquaculture system for prevention of Cyprinid herpesvirus 2 infection in gibel carp (Carassius auratus gibelio)
In conclusion, BFT could improve growth, immune response and disease resistance of gibel carp, and the effect was related with TSS concentration. The optimal TSS concentration of 600–800 mg L−1 was recommended in the present study. (Source: Fish and Shellfish Immunology)
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Identification and functional characterization of three myeloid differentiation factor 88 (MyD88) isoforms from thick shell mussel Mytilus coruscus
Publication date: Available online 8 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Baoying Guo, Shuobo Liu, Jiji Li, Zhi Liao, Huihui Liu, Hu Xia, Pengzhi QiAbstractMyeloid differentiation factor 88 (MyD88) is a pivotal adapter protein that involved in interleukin-1 receptor/toll-like receptor (IL-1R/TLR) signal transduction, which could spur downstream cascades and eventually drawn into innate immune response. MyD88 has been extensively studied in vertebrates, however, the information ascribe to MyD88 in invertebrates is still very scarce especially its function annotation remains extremely obscure. At here, three novel MyD88 isoforms termed McMyD88a, McMyD88b and McMyD88c were firstly cloned from thick shell mussel Mytilus coruscus. McMyD88a, McMyD88b and McMyD88c shared do...
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Molecular characterization of minichromosome maintenance protein (MCM7) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection
Publication date: Available online 8 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Fei Zhu, Xiyi Qian, Ziyan WangAbstractThe minichromosome maintenance protein (MCM7) is a member of the MCM protein family which participates in the MCM complex by playing a role in the cell replication cycle and chromosome initiation in eukaryotes. The 2270 bp cDNA sequence of MCM7, including a 2127-bp open reading frame (ORF) encoding a 709-aa protein, was cloned from Scylla paramamosain using RT-PCR and RACE. Data showed that MCM7 was highly expressed in the digestive organ and hepatopancreas of S. paramamosain. Furthermore, MCM7 expression was down-regulated by infection with white spot syndrome virus (WSSV) or Vibrio alginolyticus. When MCM7 was knocked down, immune genes such as Janus kina...
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Transcriptome reveals involvement of immune defense, oxidative imbalance, and apoptosis in ammonia-stress response of the black tiger shrimp (Penaeus monodon)
In conclusion, our study clarifies shrimp defensive response to ammonia toxicity and should benefit efforts to breed more ammonia-tolerant varieties. (Source: Fish and Shellfish Immunology)
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Biofloc technology (BFT): An alternative aquaculture system for prevention of Cyprinid herpesvirus 2 infection in gibel carp (Carassius auratus gibelio)
In conclusion, BFT could improve growth, immune response and disease resistance of gibel carp, and the effect was related with TSS concentration. The optimal TSS concentration of 600–800 mg L−1 was recommended in the present study. (Source: Fish and Shellfish Immunology)
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Identification and functional characterization of three myeloid differentiation factor 88 (MyD88) isoforms from thick shell mussel Mytilus coruscus
Publication date: Available online 8 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Baoying Guo, Shuobo Liu, Jiji Li, Zhi Liao, Huihui Liu, Hu Xia, Pengzhi QiAbstractMyeloid differentiation factor 88 (MyD88) is a pivotal adapter protein that involved in interleukin-1 receptor/toll-like receptor (IL-1R/TLR) signal transduction, which could spur downstream cascades and eventually drawn into innate immune response. MyD88 has been extensively studied in vertebrates, however, the information ascribe to MyD88 in invertebrates is still very scarce especially its function annotation remains extremely obscure. At here, three novel MyD88 isoforms termed McMyD88a, McMyD88b and McMyD88c were firstly cloned from thick shell mussel Mytilus coruscus. McMyD88a, McMyD88b and McMyD88c shared do...
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Molecular characterization of minichromosome maintenance protein (MCM7) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection
Publication date: Available online 8 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Fei Zhu, Xiyi Qian, Ziyan WangAbstractThe minichromosome maintenance protein (MCM7) is a member of the MCM protein family which participates in the MCM complex by playing a role in the cell replication cycle and chromosome initiation in eukaryotes. The 2270 bp cDNA sequence of MCM7, including a 2127-bp open reading frame (ORF) encoding a 709-aa protein, was cloned from Scylla paramamosain using RT-PCR and RACE. Data showed that MCM7 was highly expressed in the digestive organ and hepatopancreas of S. paramamosain. Furthermore, MCM7 expression was down-regulated by infection with white spot syndrome virus (WSSV) or Vibrio alginolyticus. When MCM7 was knocked down, immune genes such as Janus kina...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NXVdNk
Transcriptome reveals involvement of immune defense, oxidative imbalance, and apoptosis in ammonia-stress response of the black tiger shrimp (Penaeus monodon)
In conclusion, our study clarifies shrimp defensive response to ammonia toxicity and should benefit efforts to breed more ammonia-tolerant varieties. (Source: Fish and Shellfish Immunology)
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Nimodipine for the treatment of otolaryngic indications.
CONCLUSION: Due to its proposed vasoactive and neuroprotective effects, nimodipine may play a role in the treatment of a number of otolaryngic pathologies including VS, Ménière's disease, peripheral vertigo, RLN injury, and facial weakness after maxillofacial surgery. Small studies have shown improved symptom control and recovery after surgery. Since all of the aforementioned indications are still considered off label, clinicians and patients should collaboratively assess the risks and benefits before initiating treatment. PMID: 30190294 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
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The role of speech rate for Italian-speaking cochlear implant users: insights for everyday speech perception
. (Source: International Journal of Audiology)
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Construction and evaluation of the Mandarin Chinese matrix (CMNmatrix) sentence test for the assessment of speech recognition in noise
. (Source: International Journal of Audiology)
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Patients ’ experiences of living with superior canal dehiscence syndrome
. (Source: International Journal of Audiology)
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Occurrence of major complications after cochlear implant surgery in Ireland
. (Source: Cochlear Implants International)
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Nimodipine for the treatment of otolaryngic indications.
CONCLUSION: Due to its proposed vasoactive and neuroprotective effects, nimodipine may play a role in the treatment of a number of otolaryngic pathologies including VS, Ménière's disease, peripheral vertigo, RLN injury, and facial weakness after maxillofacial surgery. Small studies have shown improved symptom control and recovery after surgery. Since all of the aforementioned indications are still considered off label, clinicians and patients should collaboratively assess the risks and benefits before initiating treatment. PMID: 30190294 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
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The role of speech rate for Italian-speaking cochlear implant users: insights for everyday speech perception
. (Source: International Journal of Audiology)
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Construction and evaluation of the Mandarin Chinese matrix (CMNmatrix) sentence test for the assessment of speech recognition in noise
. (Source: International Journal of Audiology)
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Patients ’ experiences of living with superior canal dehiscence syndrome
. (Source: International Journal of Audiology)
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Occurrence of major complications after cochlear implant surgery in Ireland
. (Source: Cochlear Implants International)
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Do Infants Learn from Isolated Words? An Ecological Study
. (Source: Language Learning and Development)
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Do Infants Learn from Isolated Words? An Ecological Study
. (Source: Language Learning and Development)
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LASG Warns Against Use Of Asbestos In Homes, Says It Is Carcinogenic
| LASG Warns Against Use Of Asbestos In Homes, Says It Is Carcinogenic Independent Newspapers LimitedFull coverage |
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LASG Warns Against Use Of Asbestos In Homes, Says It Is Carcinogenic
| LASG Warns Against Use Of Asbestos In Homes, Says It Is Carcinogenic Independent Newspapers LimitedFull coverage |
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Organ donation and management of the potential organ donor
Publication date: Available online 8 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Gilly Fleming, Euan M. Thomson
Abstract
Solid organ transplant offers the potential of disease-free survival for hundreds of thousands of patients worldwide. Transplantation not only increases life expectancy and improves quality of life, but offers long-term financial savings to health care systems. The clinician's role in early identification and management of potential donors ensures that the maximum benefit can be gained from the gift of donation. A chronic shortfall in transplantable organs has led to broadened inclusion criteria for donors, and a move towards presumed consent models for donation. Protocolized and goal-directed donor management with early involvement of the transplant multidisciplinary team increases both the quality and quantity of grafts successfully donated.
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Anaesthesia and intensive care for adult liver transplantation
Publication date: Available online 8 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Craig Beattie, Michael A. Gillies
Abstract
This review describes the preoperative assessment and listing of the patient for liver transplantation and some of the perioperative challenges specific to this group of patients. The principles of the postoperative management in the intensive care unit are discussed as well as some of the signs of early graft dysfunction. Increasingly complex patients with advanced liver disease are receiving grafts from more marginal donors and this can present significant challenges to the transplant team. The anaesthetist and intensivist play a vital role in determining outcome in the perioperative period and must work collaboratively with surgeons and hepatologists to achieve the best patient outcomes.
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Organ donation and management of the potential organ donor
Publication date: Available online 8 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Gilly Fleming, Euan M. Thomson
Abstract
Solid organ transplant offers the potential of disease-free survival for hundreds of thousands of patients worldwide. Transplantation not only increases life expectancy and improves quality of life, but offers long-term financial savings to health care systems. The clinician's role in early identification and management of potential donors ensures that the maximum benefit can be gained from the gift of donation. A chronic shortfall in transplantable organs has led to broadened inclusion criteria for donors, and a move towards presumed consent models for donation. Protocolized and goal-directed donor management with early involvement of the transplant multidisciplinary team increases both the quality and quantity of grafts successfully donated.
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Anaesthesia and intensive care for adult liver transplantation
Publication date: Available online 8 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Craig Beattie, Michael A. Gillies
Abstract
This review describes the preoperative assessment and listing of the patient for liver transplantation and some of the perioperative challenges specific to this group of patients. The principles of the postoperative management in the intensive care unit are discussed as well as some of the signs of early graft dysfunction. Increasingly complex patients with advanced liver disease are receiving grafts from more marginal donors and this can present significant challenges to the transplant team. The anaesthetist and intensivist play a vital role in determining outcome in the perioperative period and must work collaboratively with surgeons and hepatologists to achieve the best patient outcomes.
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Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing
Publication date: Available online 8 September 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Timothy J. Watts, David Thursfield, Rubaiyat Haque
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Is there an overlap in immune response between allergic bronchopulmonary and chronic pulmonary aspergillosis?
Publication date: Available online 8 September 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Inderpaul Singh Sehgal, Hansraj Choudhary, Sahajal Dhooria, Ashutosh Nath Aggarwal, Mandeep Garg, Arunaloke Chakrabarti, Ritesh Agarwal
ABSTRACT
Background
Chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA) are presumed to represent two distinct manifestations of Aspergillus species in the lung.
Objective
To investigate any possible overlap of the immunological tests used for diagnosing ABPA in proven cases of CPA.
Methods
In consecutive subjects with CPA, we calculated the proportion of subjects who tested positive for all the immunological investigations used to diagnose ABPA (A.fumigatus-specific IgE >0.35 kUA/L, total IgE ≥500 IU/mL and eosinophil count ≥500 cells/μL) or obligatory criteria (A.fumigatus-specific IgE >0.35 kUA/L and total IgE ≥500 IU/mL).
Results
269 subjects (53.5% males) of CPA with mean (SD) age of 44.3 (14.7) years were enrolled. The most common underlying disease was previously treated pulmonary tuberculosis (n=230, 85.5%). Ninety-three (34.6%) subjects had total IgE ≥500 IU/mL, while A.fumigatus-specific IgE >0.35 kUA/L was seen in 112 (41.6%) subjects. Thirteen (4.8%) subjects met all the immunological criteria for ABPA, while 59 (21.9%) subjects met the obligatory criteria. Subjects meeting the obligatory criteria had significantly higher eosinophil count (p=<0.0001), greater immediate cutaneous reactivity to Aspergillus antigen (CPA-others vs. obligatory criteria, 9.8±13.9 vs. 13.9±14.9 mm, p value=0.048), higher A.fumigatus-specific IgG (99.3±61.9 vs. 122±66.6 mgA/L, p=0.015) and greater number of fungal balls (0.9±0.7 [range, 0-3] vs. 1.1±0.9 [range, 0-4], p=0.026) compared to those without.
Conclusions
About 5% of subjects with CPA fulfilled all the immunological criteria used for diagnosing ABPA while 22% met the obligatory criteria for ABPA. Whether these patients would require a different management protocol requires further investigation.
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Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing
Publication date: Available online 8 September 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Timothy J. Watts, David Thursfield, Rubaiyat Haque
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wZNZC1
Is there an overlap in immune response between allergic bronchopulmonary and chronic pulmonary aspergillosis?
Publication date: Available online 8 September 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Inderpaul Singh Sehgal, Hansraj Choudhary, Sahajal Dhooria, Ashutosh Nath Aggarwal, Mandeep Garg, Arunaloke Chakrabarti, Ritesh Agarwal
ABSTRACT
Background
Chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA) are presumed to represent two distinct manifestations of Aspergillus species in the lung.
Objective
To investigate any possible overlap of the immunological tests used for diagnosing ABPA in proven cases of CPA.
Methods
In consecutive subjects with CPA, we calculated the proportion of subjects who tested positive for all the immunological investigations used to diagnose ABPA (A.fumigatus-specific IgE >0.35 kUA/L, total IgE ≥500 IU/mL and eosinophil count ≥500 cells/μL) or obligatory criteria (A.fumigatus-specific IgE >0.35 kUA/L and total IgE ≥500 IU/mL).
Results
269 subjects (53.5% males) of CPA with mean (SD) age of 44.3 (14.7) years were enrolled. The most common underlying disease was previously treated pulmonary tuberculosis (n=230, 85.5%). Ninety-three (34.6%) subjects had total IgE ≥500 IU/mL, while A.fumigatus-specific IgE >0.35 kUA/L was seen in 112 (41.6%) subjects. Thirteen (4.8%) subjects met all the immunological criteria for ABPA, while 59 (21.9%) subjects met the obligatory criteria. Subjects meeting the obligatory criteria had significantly higher eosinophil count (p=<0.0001), greater immediate cutaneous reactivity to Aspergillus antigen (CPA-others vs. obligatory criteria, 9.8±13.9 vs. 13.9±14.9 mm, p value=0.048), higher A.fumigatus-specific IgG (99.3±61.9 vs. 122±66.6 mgA/L, p=0.015) and greater number of fungal balls (0.9±0.7 [range, 0-3] vs. 1.1±0.9 [range, 0-4], p=0.026) compared to those without.
Conclusions
About 5% of subjects with CPA fulfilled all the immunological criteria used for diagnosing ABPA while 22% met the obligatory criteria for ABPA. Whether these patients would require a different management protocol requires further investigation.
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Relationship of age to foramen of Huschke and investigation of the development of spontaneous temporomandibular joint herniation
Publication date: Available online 8 September 2018
Source: International Journal of Oral and Maxillofacial Surgery
Author(s): S. Ertugrul, N.K. Keskin
Abstract
The aim of this study was to determine the prevalence, localization, and width of the foramen of Huschke (FH) and the relationship between age and FH. Another aim was to investigate the development of spontaneous temporomandibular joint (TMJ) herniation. This was a retrospective review of high-resolution computed tomography images of the temporal bone of 1025 patients. The prevalence of FH and the axial and sagittal diameters of the foramen were evaluated. Cases were found in which the TMJ had herniated through FH into the EAC. FH was detected in 137 (13.4%) of 1025 patients. The prevalence of FH was higher in females (18.4%) than in males (6.6%) (P < 0.001). The presence of FH increased with age (P = 0.005). Herniation of the TMJ through FH into the EAC was seen in four patients (0.4%), and 2.9% of patients with FH detected had TMJ herniation into the EAC. As well as being congenital, FH can also be senile; the prevalence may increase with age. Herniation of the TMJ through FH into the EAC is very rare; this was observed in 0.4% of all patients and 2.9% of patients with FH detected.
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Management of osteoradionecrosis of the jaws with pentoxifylline–tocopherol: a systematic review of the literature and meta-analysis
Publication date: Available online 8 September 2018
Source: International Journal of Oral and Maxillofacial Surgery
Author(s): A. Kolokythas, J.T. Rasmussen, J. Reardon, C. Feng
Abstract
Osteoradionecrosis (ORN) of the jaws remains among the most commonly encountered and challenging complications of radiotherapy to the head and neck. The purpose of this study was to provide a review of the medical management for ORN and evaluate the reported outcomes with the use of pentoxifylline and tocopherol (PENTO), by means of a systematic review and meta-analysis. The predictor variable was the use of PENTO in the treatment of ORN. The outcome variable was the proportion of full recovery or significant improvement not requiring further intervention. The likelihood function was used to combine the studies and estimate the proportion and standard deviation of each outcome by the maximum likelihood estimation. Seven studies met the inclusion criteria. A total 211 patients were treated. One hundred twenty-six patients recovered fully or improved significantly not requiring further intervention. Sixty patients remained the same, 10 were lost to follow-up, and the disease progressed in 15. The current literature supports the use of PENTO in the treatment of ORN of the jaws. Additional well-designed prospective studies are needed in order to further validate the regimen that can then be employed in the treatment of ORN.
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Relationship of age to foramen of Huschke and investigation of the development of spontaneous temporomandibular joint herniation
Publication date: Available online 8 September 2018
Source: International Journal of Oral and Maxillofacial Surgery
Author(s): S. Ertugrul, N.K. Keskin
Abstract
The aim of this study was to determine the prevalence, localization, and width of the foramen of Huschke (FH) and the relationship between age and FH. Another aim was to investigate the development of spontaneous temporomandibular joint (TMJ) herniation. This was a retrospective review of high-resolution computed tomography images of the temporal bone of 1025 patients. The prevalence of FH and the axial and sagittal diameters of the foramen were evaluated. Cases were found in which the TMJ had herniated through FH into the EAC. FH was detected in 137 (13.4%) of 1025 patients. The prevalence of FH was higher in females (18.4%) than in males (6.6%) (P < 0.001). The presence of FH increased with age (P = 0.005). Herniation of the TMJ through FH into the EAC was seen in four patients (0.4%), and 2.9% of patients with FH detected had TMJ herniation into the EAC. As well as being congenital, FH can also be senile; the prevalence may increase with age. Herniation of the TMJ through FH into the EAC is very rare; this was observed in 0.4% of all patients and 2.9% of patients with FH detected.
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Management of osteoradionecrosis of the jaws with pentoxifylline–tocopherol: a systematic review of the literature and meta-analysis
Publication date: Available online 8 September 2018
Source: International Journal of Oral and Maxillofacial Surgery
Author(s): A. Kolokythas, J.T. Rasmussen, J. Reardon, C. Feng
Abstract
Osteoradionecrosis (ORN) of the jaws remains among the most commonly encountered and challenging complications of radiotherapy to the head and neck. The purpose of this study was to provide a review of the medical management for ORN and evaluate the reported outcomes with the use of pentoxifylline and tocopherol (PENTO), by means of a systematic review and meta-analysis. The predictor variable was the use of PENTO in the treatment of ORN. The outcome variable was the proportion of full recovery or significant improvement not requiring further intervention. The likelihood function was used to combine the studies and estimate the proportion and standard deviation of each outcome by the maximum likelihood estimation. Seven studies met the inclusion criteria. A total 211 patients were treated. One hundred twenty-six patients recovered fully or improved significantly not requiring further intervention. Sixty patients remained the same, 10 were lost to follow-up, and the disease progressed in 15. The current literature supports the use of PENTO in the treatment of ORN of the jaws. Additional well-designed prospective studies are needed in order to further validate the regimen that can then be employed in the treatment of ORN.
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Characteristics of diffusion-weighted images and apparent diffusion coefficients of ranulas and other masses in and around the floor of the mouth
Publication date: Available online 9 September 2018
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Nao Wakasugi-Sato, Manabu Habu DDS, Masafumi Oda, Tatsurou Tanaka, Ikuko Nishida, Tetsuro Wakasugi, Shinya Kokuryo, Daigo Yoshiga, Teppei Sago, Nozomu Harano, Shinji Kito, Shinobu Matsumoto-Takeda, Takaaki Jyoujima, Yuichi Miyamura, Naomi Yada, Masaaki Sasaguri, Yasuhiro Morimoto
Structured abstract
Objective
To evaluate the characteristics of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values of ranulas. In addition, to elucidate DWI findings and ADC values of other representative masses in and around the floor of the mouth.
Methods
DWI findings and ADC values of 35 patients with ranulas and 33 patients with other masses were retrospectively reviewed with a central focus on cystic masses or lesions that may have cyst-like components in and around the floor of the mouth based on the diagnosis of each respective disease.
Results
Ranulas were all well-defined, homogeneous masses with high signal intensity on DWI. The mean±standard deviation ADC value of the 35 ranulas was 2.59±0.31 × 10−3 mm2/s. There was a significant difference in ADC values between simple and plunging ranulas. On DWI, most other masses were heterogeneous, and most ADC values, except for thyroglossal duct cysts, hemangiomas, and pleomorphic adenomas, were significantly lower than those for ranulas.
Conclusions
The characteristic DWI and ADC findings of ranulas could be accurately recognized, and these data should be very useful in the differential diagnosis of many kinds of diseases in and around the oral floor.
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Endoscopic laryngo-pharyngeal surgery for elderly patients
Publication date: Available online 8 September 2018
Source: Auris Nasus Larynx
Author(s): Yo Kishimoto, Hiroyuki Harada, Makiko Funakoshi, Shin-ichi Miyamoto, Atsushi Suehiro, Morimasa Kitamura, Manabu Muto, Ichiro Tateya, Koichi Omori
Abstract
Objective
Due to the rising number of elderly patients and advances in endoscopic devices, early laryngeal and pharyngeal cancers are increasingly found in elderly patients. In these cases, minimally invasive endoscopic larygo-pharyngeal surgery (ELPS) may be indicated. However, the safety and efficacy of ELPS in elderly populations has not been established. The purpose of this study was to investigate the safety, outcomes and feasibility of ELPS in very elderly patients.
Methods
Between February 2010 and April 2016, 29 pharyngeal cancerous or pre-cancerous lesions in 19 patients aged 75 years or older were treated with ELPS. Twenty-six resections were performed in total, and the patients' clinical courses were reviewed.
Results
Sixteen patients had multiple comorbidities and moderate to severe comorbidities were observed in 17 patients. The average surgical time and hospitalization period was 54.3 min and 18.8 days, respectively. On average, oral intake began 4.4 days after the procedure, and all patients eventually received nourishment by mouth; no percutaneous endoscopic gastrostomy dependency was observed. Complications included post-operative bleeding and aspiration pneumonia in two cases each, and all complications were safely managed. The 3-year overall survival rate was 90.2% and the 3-year disease-specific survival rate was 100%.
Conclusion
ELPS was safely performed in elderly patients, suggesting that it is a feasible treatment option for pharyngeal lesions in very elderly patients.
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Endolymphatic hydrops severity in magnetic resonance imaging evidences disparate vestibular test results
Publication date: Available online 8 September 2018
Source: Auris Nasus Larynx
Author(s): Nicolas Pérez-Fernández, Pablo Dominguez, Raquel Manrique-Huarte, Diego Calavia, Lorea Arbizu, Reyes Garcia-Eulate, Laura Alvarez-Gomez, Carlos Guajardo, Jose Luis Zubieta
Abstract
Objectives
It has been suggested that in Ménière's disease (MD) a dissociated result in the caloric test (abnormal result) and video head-impulse test (normal result) probably indicates that hydrops affects the membranous labyrinth in the horizontal semicircular canal (HSC). The hypothesis in this study is that based on endolymphatic hydrops' cochleocentric progression, hydrops should also be more severe in the vestibule of these patients than in those for whom both tests are normal.
Methods
22 consecutive patients with unilateral definite MD were included and classified as NN if both tests were normal or AN if the caloric test was abnormal. MRI evaluation of endolymphatic hydrops was carried out with a T2-FLAIR sequence performed 4 h after intravenous gadolinium administration. The laterality and degree of vestibular endolymphatic hydrops and the presence or absence of cochlear endolymphatic hydrops were recorded. Demographic data, audiometric and vestibular evoked myogenic potentials were collected, and video head-impulse and caloric tests were performed.
Results
Patients in both groups (NN and AN) were similar in terms of demographic data and hearing loss. The interaural asymmetry ratio was significantly higher for ocular and cervical VEMP in patients in the AN group. There was a significantly higher degree of hydrops in the vestibule of the affected ear of AN patients (χ2; p = 0.028).
Conclusion
Significant canal paresis in the caloric test is associated with more severe endolymphatic hydrops in the vestibule as detected with gadolinium-enhanced MRI and with a more severe vestibular deficit.
Level of evidence: 2a
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Characteristics of diffusion-weighted images and apparent diffusion coefficients of ranulas and other masses in and around the floor of the mouth
Publication date: Available online 9 September 2018
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Nao Wakasugi-Sato, Manabu Habu DDS, Masafumi Oda, Tatsurou Tanaka, Ikuko Nishida, Tetsuro Wakasugi, Shinya Kokuryo, Daigo Yoshiga, Teppei Sago, Nozomu Harano, Shinji Kito, Shinobu Matsumoto-Takeda, Takaaki Jyoujima, Yuichi Miyamura, Naomi Yada, Masaaki Sasaguri, Yasuhiro Morimoto
Structured abstract
Objective
To evaluate the characteristics of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values of ranulas. In addition, to elucidate DWI findings and ADC values of other representative masses in and around the floor of the mouth.
Methods
DWI findings and ADC values of 35 patients with ranulas and 33 patients with other masses were retrospectively reviewed with a central focus on cystic masses or lesions that may have cyst-like components in and around the floor of the mouth based on the diagnosis of each respective disease.
Results
Ranulas were all well-defined, homogeneous masses with high signal intensity on DWI. The mean±standard deviation ADC value of the 35 ranulas was 2.59±0.31 × 10−3 mm2/s. There was a significant difference in ADC values between simple and plunging ranulas. On DWI, most other masses were heterogeneous, and most ADC values, except for thyroglossal duct cysts, hemangiomas, and pleomorphic adenomas, were significantly lower than those for ranulas.
Conclusions
The characteristic DWI and ADC findings of ranulas could be accurately recognized, and these data should be very useful in the differential diagnosis of many kinds of diseases in and around the oral floor.
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Endoscopic laryngo-pharyngeal surgery for elderly patients
Publication date: Available online 8 September 2018
Source: Auris Nasus Larynx
Author(s): Yo Kishimoto, Hiroyuki Harada, Makiko Funakoshi, Shin-ichi Miyamoto, Atsushi Suehiro, Morimasa Kitamura, Manabu Muto, Ichiro Tateya, Koichi Omori
Abstract
Objective
Due to the rising number of elderly patients and advances in endoscopic devices, early laryngeal and pharyngeal cancers are increasingly found in elderly patients. In these cases, minimally invasive endoscopic larygo-pharyngeal surgery (ELPS) may be indicated. However, the safety and efficacy of ELPS in elderly populations has not been established. The purpose of this study was to investigate the safety, outcomes and feasibility of ELPS in very elderly patients.
Methods
Between February 2010 and April 2016, 29 pharyngeal cancerous or pre-cancerous lesions in 19 patients aged 75 years or older were treated with ELPS. Twenty-six resections were performed in total, and the patients' clinical courses were reviewed.
Results
Sixteen patients had multiple comorbidities and moderate to severe comorbidities were observed in 17 patients. The average surgical time and hospitalization period was 54.3 min and 18.8 days, respectively. On average, oral intake began 4.4 days after the procedure, and all patients eventually received nourishment by mouth; no percutaneous endoscopic gastrostomy dependency was observed. Complications included post-operative bleeding and aspiration pneumonia in two cases each, and all complications were safely managed. The 3-year overall survival rate was 90.2% and the 3-year disease-specific survival rate was 100%.
Conclusion
ELPS was safely performed in elderly patients, suggesting that it is a feasible treatment option for pharyngeal lesions in very elderly patients.
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Endolymphatic hydrops severity in magnetic resonance imaging evidences disparate vestibular test results
Publication date: Available online 8 September 2018
Source: Auris Nasus Larynx
Author(s): Nicolas Pérez-Fernández, Pablo Dominguez, Raquel Manrique-Huarte, Diego Calavia, Lorea Arbizu, Reyes Garcia-Eulate, Laura Alvarez-Gomez, Carlos Guajardo, Jose Luis Zubieta
Abstract
Objectives
It has been suggested that in Ménière's disease (MD) a dissociated result in the caloric test (abnormal result) and video head-impulse test (normal result) probably indicates that hydrops affects the membranous labyrinth in the horizontal semicircular canal (HSC). The hypothesis in this study is that based on endolymphatic hydrops' cochleocentric progression, hydrops should also be more severe in the vestibule of these patients than in those for whom both tests are normal.
Methods
22 consecutive patients with unilateral definite MD were included and classified as NN if both tests were normal or AN if the caloric test was abnormal. MRI evaluation of endolymphatic hydrops was carried out with a T2-FLAIR sequence performed 4 h after intravenous gadolinium administration. The laterality and degree of vestibular endolymphatic hydrops and the presence or absence of cochlear endolymphatic hydrops were recorded. Demographic data, audiometric and vestibular evoked myogenic potentials were collected, and video head-impulse and caloric tests were performed.
Results
Patients in both groups (NN and AN) were similar in terms of demographic data and hearing loss. The interaural asymmetry ratio was significantly higher for ocular and cervical VEMP in patients in the AN group. There was a significantly higher degree of hydrops in the vestibule of the affected ear of AN patients (χ2; p = 0.028).
Conclusion
Significant canal paresis in the caloric test is associated with more severe endolymphatic hydrops in the vestibule as detected with gadolinium-enhanced MRI and with a more severe vestibular deficit.
Level of evidence: 2a
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Les prothèses mammaires : quelles offres sur le marché français
Publication date: Available online 8 September 2018
Source: Annales de Chirurgie Plastique Esthétique
Author(s): R. Sinna
Résumé
Le choix dans le type d'implant que le chirurgien utilise se fait souvent sur des arguments médico-commerciaux, des croyances, et du ressenti subjectif plutôt que sur de réels arguments scientifiques. Nous avons rarement l'occasion de comparer de manières objectives les fabricants entre eux. Ainsi notre objectif ici a été simplement de regrouper sur un même support l'ensemble des spécificités des différents acteurs du marché français. Ceci aussi bien sur le plan technique que sur le plan de l'offre commerciale.
Summary
The choice of an implant by a plastic surgeon is often based on marketing arguments, beliefs, and subjective reasons more than real high level evidence basis. Furthermore, we rarely compare manufacturers with each other objectively. Therefore our aim was to put together information coming from the different companies available in France in a single article.
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Les prothèses mammaires : quelles offres sur le marché français
Publication date: Available online 8 September 2018
Source: Annales de Chirurgie Plastique Esthétique
Author(s): R. Sinna
Résumé
Le choix dans le type d'implant que le chirurgien utilise se fait souvent sur des arguments médico-commerciaux, des croyances, et du ressenti subjectif plutôt que sur de réels arguments scientifiques. Nous avons rarement l'occasion de comparer de manières objectives les fabricants entre eux. Ainsi notre objectif ici a été simplement de regrouper sur un même support l'ensemble des spécificités des différents acteurs du marché français. Ceci aussi bien sur le plan technique que sur le plan de l'offre commerciale.
Summary
The choice of an implant by a plastic surgeon is often based on marketing arguments, beliefs, and subjective reasons more than real high level evidence basis. Furthermore, we rarely compare manufacturers with each other objectively. Therefore our aim was to put together information coming from the different companies available in France in a single article.
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Lagos govt warns against use of asbestos in homes
| Lagos govt warns against use of asbestos in homes Premium TimesFull coverage |
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Impact of Unilateral Congenital Aural Atresia on Academic Performance:a Systematic Review
Publication date: Available online 8 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): C.V.A. van Hövell tot Westerflier, J.A.A. van Heteren, C.C. Breugem, A.L. Smit, I. Stegeman
Abstract
Background
Little is known about the academic performance of children with unilateral congenital aural atresia (CAA).
Objective
of review: Our objective was to summarize what is known about the academic performance of children with hearing loss by unilateral congenital aural atresia, in order to provide pragmatic recommendations to clinicians who see children with this entity.
Type of review
Systematic review.
Search strategy
We conducted a systematic search in PubMed Medline, EMBASE, and Cochrane Library combining the terms "atresia" and synonyms with "unilateral hearing loss" and synonyms. Date of the most recent search was 16 May 2018.
Evaluation method
Two independent authors identified studies, extracted data, and assessed risk of bias. This review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Observational studies on the academic achievements of patients of any age with unilateral conductive hearing loss of any level due to congenital aural atresia were included. We considered grade retention, special education, individualized education plans, and parental report of school performance as outcome measures for academic achievement.Results: Two studies reporting on academic performance of patients with unilateral CAA, which both had a significant risk of bias. One study (n = 140) showed a grade retention rate of 3.6% (n = 5) in total. 15.7 % (n = 22) needed special education, and 36.4% (n = 51) used an individualized education program. The second study, reporting on 67 patients with unilateral CAA, showed that 29.9% (n = 20) of the patients received school intervention, and 25.4% (n = 17) had learning problems.
Conclusion
Current evidence regarding the effect of unilateral congenital aural atresia on academic performance is sparse, inconclusive and has a significant risk of bias. High quality observational studies assessing the effects of aural atresia on academic performance in these patients should be initiated.
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Anaplastic Thyroid Cancer Drug | Global market 2018-2023 analysis (Major Players:Daiichi Sankyo Company, Limited ...
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Lagos govt warns against use of asbestos in homes
| Lagos govt warns against use of asbestos in homes Premium TimesFull coverage |
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CyoQ6w
Impact of Unilateral Congenital Aural Atresia on Academic Performance:a Systematic Review
Publication date: Available online 8 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): C.V.A. van Hövell tot Westerflier, J.A.A. van Heteren, C.C. Breugem, A.L. Smit, I. Stegeman
Abstract
Background
Little is known about the academic performance of children with unilateral congenital aural atresia (CAA).
Objective
of review: Our objective was to summarize what is known about the academic performance of children with hearing loss by unilateral congenital aural atresia, in order to provide pragmatic recommendations to clinicians who see children with this entity.
Type of review
Systematic review.
Search strategy
We conducted a systematic search in PubMed Medline, EMBASE, and Cochrane Library combining the terms "atresia" and synonyms with "unilateral hearing loss" and synonyms. Date of the most recent search was 16 May 2018.
Evaluation method
Two independent authors identified studies, extracted data, and assessed risk of bias. This review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Observational studies on the academic achievements of patients of any age with unilateral conductive hearing loss of any level due to congenital aural atresia were included. We considered grade retention, special education, individualized education plans, and parental report of school performance as outcome measures for academic achievement.Results: Two studies reporting on academic performance of patients with unilateral CAA, which both had a significant risk of bias. One study (n = 140) showed a grade retention rate of 3.6% (n = 5) in total. 15.7 % (n = 22) needed special education, and 36.4% (n = 51) used an individualized education program. The second study, reporting on 67 patients with unilateral CAA, showed that 29.9% (n = 20) of the patients received school intervention, and 25.4% (n = 17) had learning problems.
Conclusion
Current evidence regarding the effect of unilateral congenital aural atresia on academic performance is sparse, inconclusive and has a significant risk of bias. High quality observational studies assessing the effects of aural atresia on academic performance in these patients should be initiated.
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Anaplastic Thyroid Cancer Drug | Global market 2018-2023 analysis (Major Players:Daiichi Sankyo Company, Limited ...
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LASG warns against use of asbestos in homes, says it is carcinogenic
| LASG warns against use of asbestos in homes, says it is carcinogenic Daily SunFull coverage |
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The use of asbestos can cause cancer – Lagos Commissioner
| The use of asbestos can cause cancer – Lagos Commissioner VanguardFull coverage |
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Characteristics of NSAID ‐induced Hypersensitivity Reactions in Childhood
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
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Improved lung function at age 6 in children born very preterm and fed extra protein post discharge
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
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Palatability of Hypoallergenic Formulas for Cow's Milk Allergy and Healthcare Professional Recommendation
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
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LASG warns against use of asbestos in homes, says it is carcinogenic
| LASG warns against use of asbestos in homes, says it is carcinogenic Daily SunFull coverage |
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The use of asbestos can cause cancer – Lagos Commissioner
| The use of asbestos can cause cancer – Lagos Commissioner VanguardFull coverage |
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Characteristics of NSAID ‐induced Hypersensitivity Reactions in Childhood
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
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Improved lung function at age 6 in children born very preterm and fed extra protein post discharge
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
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Palatability of Hypoallergenic Formulas for Cow's Milk Allergy and Healthcare Professional Recommendation
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
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Revisiting the dose constraints for head and neck OARs in the current era of IMRT
Publication date: November 2018
Source: Oral Oncology, Volume 86
Author(s): N.Patrik Brodin, Wolfgang A. Tomé
Abstract
Head and neck cancer poses a particular challenge in radiation therapy, whilst being an effective treatment modality it requires very high doses of radiation to provide effective therapy. This is further complicated by the fact that the head and neck region contains a large number of radiosensitive tissues, often resulting in patients experiencing debilitating normal tissue complications. In the era of intensity-modulated radiation therapy (IMRT) treatments can be delivered using non-uniform dose distributions selectively aimed at reducing the dose to critical organs-at-risk while still adequately covering the tumor target. Dose-volume constraints for the different risk organs play a vital role in one's ability to devise the best IMRT treatment plan for a head and neck cancer patient. To this end, it is pivotal to have access to the latest and most relevant dose constraints available and as such the goal of this review is to provide a summary of suggested dose-volume constraints for head and neck cancer RT that have been published after the QUANTEC reports were made available in early 2010.
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‘Meditation Training Intervention’ – A necessary shift for head and neck cancer patients
Publication date: Available online 8 September 2018
Source: Oral Oncology
Author(s): Prashanth Panta
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Revisiting the dose constraints for head and neck OARs in the current era of IMRT
Publication date: November 2018
Source: Oral Oncology, Volume 86
Author(s): N.Patrik Brodin, Wolfgang A. Tomé
Abstract
Head and neck cancer poses a particular challenge in radiation therapy, whilst being an effective treatment modality it requires very high doses of radiation to provide effective therapy. This is further complicated by the fact that the head and neck region contains a large number of radiosensitive tissues, often resulting in patients experiencing debilitating normal tissue complications. In the era of intensity-modulated radiation therapy (IMRT) treatments can be delivered using non-uniform dose distributions selectively aimed at reducing the dose to critical organs-at-risk while still adequately covering the tumor target. Dose-volume constraints for the different risk organs play a vital role in one's ability to devise the best IMRT treatment plan for a head and neck cancer patient. To this end, it is pivotal to have access to the latest and most relevant dose constraints available and as such the goal of this review is to provide a summary of suggested dose-volume constraints for head and neck cancer RT that have been published after the QUANTEC reports were made available in early 2010.
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‘Meditation Training Intervention’ – A necessary shift for head and neck cancer patients
Publication date: Available online 8 September 2018
Source: Oral Oncology
Author(s): Prashanth Panta
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Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid.
In conclusion, submicroscopic Plasmodium infection altered the development of the immune response to the TT vaccine in Colombian pregnant women. The impact of Plasmodium infections on the immune regulatory pathways warrants further exploration. This article is protected by copyright. All rights reserved. PMID: 30194852 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
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STAT6 & IL ‐10 are required for the anti‐arthritic effects of Schistosoma mansoni via different mechanisms
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
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Modulation of trophoblast function by concurrent hyperglycemia and antiphospholipid antibodies is in part TLR4 ‐dependent
American Journal of Reproductive Immunology, EarlyView. (Source: American Journal of Reproductive Immunology)
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Characteristics of NSAID ‐induced Hypersensitivity Reactions in Childhood
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wUPEsH
Improved lung function at age 6 in children born very preterm and fed extra protein post discharge
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CBrcSo
STAT6 & IL-10 are required for the anti-arthritic effects of Schistosoma mansoni via different mechanisms.
This article is protected by copyright. All rights reserved. PMID: 30194773 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wUqnic
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid.
In conclusion, submicroscopic Plasmodium infection altered the development of the immune response to the TT vaccine in Colombian pregnant women. The impact of Plasmodium infections on the immune regulatory pathways warrants further exploration. This article is protected by copyright. All rights reserved. PMID: 30194852 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wUUqX6
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CCRzHH
STAT6 & IL ‐10 are required for the anti‐arthritic effects of Schistosoma mansoni via different mechanisms
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wW7cVj
Modulation of trophoblast function by concurrent hyperglycemia and antiphospholipid antibodies is in part TLR4 ‐dependent
American Journal of Reproductive Immunology, EarlyView. (Source: American Journal of Reproductive Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CN9QCf
Characteristics of NSAID ‐induced Hypersensitivity Reactions in Childhood
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wUPEsH
Improved lung function at age 6 in children born very preterm and fed extra protein post discharge
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CBrcSo
STAT6 & IL-10 are required for the anti-arthritic effects of Schistosoma mansoni via different mechanisms.
This article is protected by copyright. All rights reserved. PMID: 30194773 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Why The Cancer Death Of A Fukushima Worker Was Likely Not Due To Fukushima
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Why The Cancer Death Of A Fukushima Worker Was Likely Not Due To Fukushima
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The cephalic tetanus of rose: A rare clinical entity
Publication date: Available online 8 September 2018
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Author(s): Arnaud Salami, Nadine Yavo, Camille Assouan, Dine Mourtada
Abstract
Peripheral facial palsy is caused by a variety of aetiologies. The cephalic tetanus of Rose is a very infrequent, life-threatening aetiology and has become rare in countries with high tetanus immunization coverage. It's a disease bad known by head and neck specialists. The authors report a case of Rose cephalic tetanus revealed by a peripheral facial palsy.
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