Condition: HIV Interventions: Biological: VRC-HIVMAB060-00-AB (VRC01); Biological: 10-1074; Biological: Normal Saline Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Κυριακή 10 Φεβρουαρίου 2019
Combination Therapy With VRC-HIVMAB060-00-AB (VRC01) and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions
The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers
Condition: Opioid Addiction Interventions: Drug: MDZ; Drug: ANS-6637 Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Srx1JE
Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet
Conditions: Intervention; Food Allergy; Food Preferences; Food Intolerance; Diet Habit; Diet Modification Intervention: Behavioral: Multicomponent intervention Sponsors: University Rovira i Virgili; Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DpOsQl
Retrospective Chart Review of Candida Fungemia
Condition: Candida Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsfiSn
Allergy UK Research and Development Nurse Project
Condition: Allergy Intervention: Other: Nurse Led Allergy Clinic Sponsors: University of Edinburgh; Allergy UK Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DqPQSS
Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population
Conditions: Hepatitis E; Immunisation Interventions: Biological: HEV 239; Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2StLvIP
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Conditions: Pulmonary Invasive Mold Infections; Pulmonary Invasive Aspergillosis Intervention: Diagnostic Test: Non-Invasive Testing for PIMI Sponsors: Duke University; Children's Hospital of Philadelphia; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dsu94M
Combination Therapy With VRC-HIVMAB060-00-AB (VRC01) and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions
Condition: HIV Interventions: Biological: VRC-HIVMAB060-00-AB (VRC01); Biological: 10-1074; Biological: Normal Saline Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DsdIWk
The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers
Condition: Opioid Addiction Interventions: Drug: MDZ; Drug: ANS-6637 Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Srx1JE
Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet
Conditions: Intervention; Food Allergy; Food Preferences; Food Intolerance; Diet Habit; Diet Modification Intervention: Behavioral: Multicomponent intervention Sponsors: University Rovira i Virgili; Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DpOsQl
Retrospective Chart Review of Candida Fungemia
Condition: Candida Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsfiSn
Allergy UK Research and Development Nurse Project
Condition: Allergy Intervention: Other: Nurse Led Allergy Clinic Sponsors: University of Edinburgh; Allergy UK Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DqPQSS
Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population
Conditions: Hepatitis E; Immunisation Interventions: Biological: HEV 239; Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2StLvIP
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Conditions: Pulmonary Invasive Mold Infections; Pulmonary Invasive Aspergillosis Intervention: Diagnostic Test: Non-Invasive Testing for PIMI Sponsors: Duke University; Children's Hospital of Philadelphia; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dsu94M
False negative rate of fine‐needle aspiration in thyroid nodules: impact of nodule size and ultrasound pattern
Abstract
Background
To retrospectively evaluate the false negative rate of ultrasound‐guided fine needle aspiration (FNA) according to the nodule size and ultrasound pattern.
Methods
We included 432 consecutive thyroid nodules from 384 patients who underwent ultrasound‐guided FNA with benign results (≥1 cm). The false negative rate in the nodules was assessed according to the nodule size and ultrasound pattern based on the Korean‐Thyroid Imaging Reporting and Data System (K‐TIRADS).
Results
The overall false negative rate was 3.2%. There was a trend toward an increasing false negative rate as the K‐TIRADS score increased (P < .001). In low or high suspicion nodules (K‐TIRADS 3 and 5), there was no significant difference in false negative rate according to the nodule size; however, among the intermediate suspicion nodules (K‐TIRADS 4), the false negative rate was higher in large nodules (≥3 cm, P = .039).
Conclusion
The impact of nodule size on the false negative rate differed according to the ultrasound pattern.
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False negative rate of fine‐needle aspiration in thyroid nodules: impact of nodule size and ultrasound pattern
Abstract
Background
To retrospectively evaluate the false negative rate of ultrasound‐guided fine needle aspiration (FNA) according to the nodule size and ultrasound pattern.
Methods
We included 432 consecutive thyroid nodules from 384 patients who underwent ultrasound‐guided FNA with benign results (≥1 cm). The false negative rate in the nodules was assessed according to the nodule size and ultrasound pattern based on the Korean‐Thyroid Imaging Reporting and Data System (K‐TIRADS).
Results
The overall false negative rate was 3.2%. There was a trend toward an increasing false negative rate as the K‐TIRADS score increased (P < .001). In low or high suspicion nodules (K‐TIRADS 3 and 5), there was no significant difference in false negative rate according to the nodule size; however, among the intermediate suspicion nodules (K‐TIRADS 4), the false negative rate was higher in large nodules (≥3 cm, P = .039).
Conclusion
The impact of nodule size on the false negative rate differed according to the ultrasound pattern.
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TWiV 534: Portal to the METTL
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Calicivirus portal visualized (Nature) Calicivirus portal - long version (biorXiv) m6A modification and innate response (Nat Immunol) Brianne Barker's immunology course m6A modification and innate response (Genes Dev) Letters read on TWiV 534 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - The Red Queen's Race Car...
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Randy Q. Cron, MD, PhD - Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment
Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment (Source: PeerView CME/CE Audio Podcast - Immunology)
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TWiV 534: Portal to the METTL
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Calicivirus portal visualized (Nature) Calicivirus portal - long version (biorXiv) m6A modification and innate response (Nat Immunol) Brianne Barker's immunology course m6A modification and innate response (Genes Dev) Letters read on TWiV 534 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - The Red Queen's Race Car...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BsgiLO
Randy Q. Cron, MD, PhD - Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment
Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment (Source: PeerView CME/CE Audio Podcast - Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TIsVt8
Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
Abstract
Background
Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity.
Material and method
A cross-sectional multicentre study enrolled children aged 6–7 and 13–14 years and adults aged 20–44 years from a Polish national cohort. The diagnosis of allergic diseases was made by a physician. Skin prick tests to 13 allergens and serum IgE levels to 4 allergens were tested.
Results
Among the 3856 participants, single disease (asthma, allergic rhinitis or atopic dermatitis) was diagnosed in 27.7% subjects and allergic multimorbidity in 9.3%. Allergic multimorbidity occurred more commonly in children than in adults (p < 0.01). Asthma or atopic dermatitis alone were not associated with polysensitization. Rhinitis and multimorbidity were associated with polysensitization. Allergic multimorbidity occurred in 2.2% of participants with negative skin prick tests, 9.8% of those with one positive prick test (SPT ≥ 3 mm) and 20.6% of polysensitized ones (p < 0.001). There was an increasing risk of multimorbidity depending on the number of positive prick tests for both SPT ≥ 3 mm (OR 9.6–16.5) and SPT ≥ 6 mm (OR 5.9–13.7). A statistically significant relationship was found between allergic multimorbidity and sensitization to cat and mite allergens.
Conclusions
Multimorbidity is associated with polysensitization especially in children compared with adults in Polish population cohort. New insights into single disease patterns were found: bronchial asthma is the strongest risk factor for the development of multimorbidity in comparison with allergic rhinitis and atopic dermatitis.
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Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
Abstract
Background
Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity.
Material and method
A cross-sectional multicentre study enrolled children aged 6–7 and 13–14 years and adults aged 20–44 years from a Polish national cohort. The diagnosis of allergic diseases was made by a physician. Skin prick tests to 13 allergens and serum IgE levels to 4 allergens were tested.
Results
Among the 3856 participants, single disease (asthma, allergic rhinitis or atopic dermatitis) was diagnosed in 27.7% subjects and allergic multimorbidity in 9.3%. Allergic multimorbidity occurred more commonly in children than in adults (p < 0.01). Asthma or atopic dermatitis alone were not associated with polysensitization. Rhinitis and multimorbidity were associated with polysensitization. Allergic multimorbidity occurred in 2.2% of participants with negative skin prick tests, 9.8% of those with one positive prick test (SPT ≥ 3 mm) and 20.6% of polysensitized ones (p < 0.001). There was an increasing risk of multimorbidity depending on the number of positive prick tests for both SPT ≥ 3 mm (OR 9.6–16.5) and SPT ≥ 6 mm (OR 5.9–13.7). A statistically significant relationship was found between allergic multimorbidity and sensitization to cat and mite allergens.
Conclusions
Multimorbidity is associated with polysensitization especially in children compared with adults in Polish population cohort. New insights into single disease patterns were found: bronchial asthma is the strongest risk factor for the development of multimorbidity in comparison with allergic rhinitis and atopic dermatitis.
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Treatment fidelity in aphasia randomised controlled trials
. (Source: Aphasiology)
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Management of velopharyngeal insufficiency by modified Furlow palatoplasty with pharyngeal flap: a retrospective outcome review
The surgical approach for the correction of residual velopharyngeal insufficiency requiring secondary surgery at Chang Gung Memorial Hospital is the modified Furlow palatoplasty with pharyngeal flap (mFP-PF). The aim of this study was to describe the mFP-PF technique and to determine the results obtained with regard to improvements in velopharyngeal function in patients undergoing this surgery. This retrospective analysis included 58 non-syndromic patients treated during the period 1992 –2015 who complained of hypernasal speech after primary cleft palate repair and failed postoperative speech therapy. (Source: International Journal of Oral and Maxillofacial Surgery)
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Efficacy of elaborated semantic features analysis in Aphasia: a quasi-randomised controlled trial
. (Source: Aphasiology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2E418Om
Management of velopharyngeal insufficiency by modified Furlow palatoplasty with pharyngeal flap: a retrospective outcome review
The surgical approach for the correction of residual velopharyngeal insufficiency requiring secondary surgery at Chang Gung Memorial Hospital is the modified Furlow palatoplasty with pharyngeal flap (mFP-PF). The aim of this study was to describe the mFP-PF technique and to determine the results obtained with regard to improvements in velopharyngeal function in patients undergoing this surgery. This retrospective analysis included 58 non-syndromic patients treated during the period 1992 –2015 who complained of hypernasal speech after primary cleft palate repair and failed postoperative speech therapy. (Source: International Journal of Oral and Maxillofacial Surgery)
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Treatment fidelity in aphasia randomised controlled trials
. (Source: Aphasiology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GAKFmD
Efficacy of elaborated semantic features analysis in Aphasia: a quasi-randomised controlled trial
. (Source: Aphasiology)
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Atypical variants of posterior canal benign paroxysmal positional vertigo after canalith repositioning: a case report
. (Source: Hearing, Balance and Communication)
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Effect of auditory status on visual emotion recognition in adolescents
. (Source: Cochlear Implants International)
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sqy78e
Pulse-wave velocity and benign paroxysmal positional vertigo (BPPV)
. (Source: Hearing, Balance and Communication)
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Atypical variants of posterior canal benign paroxysmal positional vertigo after canalith repositioning: a case report
. (Source: Hearing, Balance and Communication)
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Effect of auditory status on visual emotion recognition in adolescents
. (Source: Cochlear Implants International)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Pulse-wave velocity and benign paroxysmal positional vertigo (BPPV)
. (Source: Hearing, Balance and Communication)
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Allergic contact dermatitis to (meth)acrylates involving nail technicians and users: prognosis and differential diagnosis
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Allergic contact dermatitis to (meth)acrylates involving nail technicians and users: prognosis and differential diagnosis
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TH0coF
Combination Therapy With VRC-HIVMAB060-00-AB (VRC01) and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions
Condition: HIV Interventions: Biological: VRC-HIVMAB060-00-AB (VRC01); Biological: 10-1074; Biological: Normal Saline Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SncXYW
The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers
Condition: Opioid Addiction Interventions: Drug: MDZ; Drug: ANS-6637 Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dlj45m
Retrospective Chart Review of Candida Fungemia
Condition: Candida Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Soyn81
Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet
Conditions: Intervention; Food Allergy; Food Preferences; Food Intolerance; Diet Habit; Diet Modification Intervention: Behavioral: Multicomponent intervention Sponsors: University Rovira i Virgili; Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dtkc7h
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Conditions: Pulmonary Invasive Mold Infections; Pulmonary Invasive Aspergillosis Intervention: Diagnostic Test: Non-Invasive Testing for PIMI Sponsors: Duke University; Children's Hospital of Philadelphia; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Snf92l
Allergy UK Research and Development Nurse Project
Condition: Allergy Intervention: Other: Nurse Led Allergy Clinic Sponsors: University of Edinburgh; Allergy UK Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DoJ1Bl
Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population
Conditions: Hepatitis E; Immunisation Interventions: Biological: HEV 239; Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SolECb
Combination Therapy With VRC-HIVMAB060-00-AB (VRC01) and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions
Condition: HIV Interventions: Biological: VRC-HIVMAB060-00-AB (VRC01); Biological: 10-1074; Biological: Normal Saline Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SncXYW
The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers
Condition: Opioid Addiction Interventions: Drug: MDZ; Drug: ANS-6637 Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dlj45m
Retrospective Chart Review of Candida Fungemia
Condition: Candida Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Soyn81
Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet
Conditions: Intervention; Food Allergy; Food Preferences; Food Intolerance; Diet Habit; Diet Modification Intervention: Behavioral: Multicomponent intervention Sponsors: University Rovira i Virgili; Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dtkc7h
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Conditions: Pulmonary Invasive Mold Infections; Pulmonary Invasive Aspergillosis Intervention: Diagnostic Test: Non-Invasive Testing for PIMI Sponsors: Duke University; Children's Hospital of Philadelphia; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Snf92l
Allergy UK Research and Development Nurse Project
Condition: Allergy Intervention: Other: Nurse Led Allergy Clinic Sponsors: University of Edinburgh; Allergy UK Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DoJ1Bl
Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population
Conditions: Hepatitis E; Immunisation Interventions: Biological: HEV 239; Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SolECb
T2 mapping with 3.0 T MRI of the temporomandibular joint disc of patients with disc dislocation
Publication date: Available online 10 February 2019
Source: Magnetic Resonance Imaging
Author(s): Margit Bristela, Astrid Skolka, Jaryna Eder, Pavol Szomolanyi, Michael Weber, Eva Piehslinger, Martina Schmid-Schwap, Siegfried Trattnig
Abstract
Introduction
T2 mapping, as a quantitative biochemical MRI-technique that provides information on water and collagen fiber content and composition, was shown to be clinically feasible for the evaluation of healthy temporomandibular joints.
Objectives
The aim of our study was to compare the T2 values of whole discs in patients with and without disc dislocation, to evaluate the possible influence of morphological findings on T2 values and to assess the interrater agreement.
Methods
Sixty-six patients were included in the study. Three experienced examiners assessed the perceptibility of the morphological parameters and the position of the articular disc on the morphological MR images. On the T2 maps, the T2 values of the region-of-interest (ROI) were assessed.
Results
The ICC (Intraclass Correlation Coefficient) for the reproducibility of the T2 values was 0.717. The assessment of the morphologic parameters was excellent or good in most of the discs. There was no significant difference in the T2 values based on disc position or signal intensity. But, a statistically significant moderation effect (p = .014) could be identified, indicating that the effect of disc position differs for different signal intensities. Condyle position, effusion, and degenerative changes showed pronounced moderation effects on the T2 values.
Conclusion
Due to the high sensitivity to effusion, T2 mapping currently seems to be unsuitable as a diagnostic tool for routine use in the temporomandibular joint. The moderation effect clearly shows the influence of factors such as signal intensity, effusion, arthrosis, and condyle position. Perhaps a solution for these problems could be the development of dedicated TMJ coils for higher field strengths at 7.0 T.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2THwIH8
T2 mapping with 3.0 T MRI of the temporomandibular joint disc of patients with disc dislocation
Publication date: Available online 10 February 2019
Source: Magnetic Resonance Imaging
Author(s): Margit Bristela, Astrid Skolka, Jaryna Eder, Pavol Szomolanyi, Michael Weber, Eva Piehslinger, Martina Schmid-Schwap, Siegfried Trattnig
Abstract
Introduction
T2 mapping, as a quantitative biochemical MRI-technique that provides information on water and collagen fiber content and composition, was shown to be clinically feasible for the evaluation of healthy temporomandibular joints.
Objectives
The aim of our study was to compare the T2 values of whole discs in patients with and without disc dislocation, to evaluate the possible influence of morphological findings on T2 values and to assess the interrater agreement.
Methods
Sixty-six patients were included in the study. Three experienced examiners assessed the perceptibility of the morphological parameters and the position of the articular disc on the morphological MR images. On the T2 maps, the T2 values of the region-of-interest (ROI) were assessed.
Results
The ICC (Intraclass Correlation Coefficient) for the reproducibility of the T2 values was 0.717. The assessment of the morphologic parameters was excellent or good in most of the discs. There was no significant difference in the T2 values based on disc position or signal intensity. But, a statistically significant moderation effect (p = .014) could be identified, indicating that the effect of disc position differs for different signal intensities. Condyle position, effusion, and degenerative changes showed pronounced moderation effects on the T2 values.
Conclusion
Due to the high sensitivity to effusion, T2 mapping currently seems to be unsuitable as a diagnostic tool for routine use in the temporomandibular joint. The moderation effect clearly shows the influence of factors such as signal intensity, effusion, arthrosis, and condyle position. Perhaps a solution for these problems could be the development of dedicated TMJ coils for higher field strengths at 7.0 T.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2THwIH8
Guidelines for best practice: Imaging for Age Estimation in the Living
Publication date: Available online 10 February 2019
Source: Journal of Forensic Radiology and Imaging
Author(s): Edel Doyle, Nicholas Márquez-Grant, Lisa Field, Trish Holmes, Owen J Arthurs, Rick R. van Rijn, Lucina Hackman, Kathleen Kasper, Jim Lewis, Peter Loomis, Denise Elliott, Jeroen Kroll, Mark Viner, Soren Blau, Alison Brough, Stella Martín de las Heras, Pedro Manuel Garamendi
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Guidelines for best practice: Imaging for Age Estimation in the Living
Publication date: Available online 10 February 2019
Source: Journal of Forensic Radiology and Imaging
Author(s): Edel Doyle, Nicholas Márquez-Grant, Lisa Field, Trish Holmes, Owen J Arthurs, Rick R. van Rijn, Lucina Hackman, Kathleen Kasper, Jim Lewis, Peter Loomis, Denise Elliott, Jeroen Kroll, Mark Viner, Soren Blau, Alison Brough, Stella Martín de las Heras, Pedro Manuel Garamendi
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The importance of BRAF‐V600E mutation to ameloblastoma metabolism
Abstract
Background
Ameloblastoma is a locally infiltrative, aggressive epithelial odontogenic neoplasm. BRAF‐V600E mutation is frequently found in this tumor and has a pivotal role in its pathogenesis, but the consequences of this alteration need to be addressed. An untargeted metabolomics approach was applied to verify whether metabolic disturbances are related to tumor biology and whether BRAF‐V600E mutation contributes to these alterations.
Methods
Formalin‐fixed and paraffin‐embedded tissue specimens from thirteen ameloblastoma and six dental follicles were included in this study. BRAF mutational status was determined by competitive allele‐specific real‐time PCR. Metabolite extracts were analyzed using gas chromatography coupled to mass spectrometry. Univariate and multivariate statistical methods were employed to compare the metabolic profiles of the samples.
Results
The abundance of eleven metabolites were significantly higher in ameloblastoma in relation to dental follicles, including amino acids, fatty acids, carbohydrates, inorganic acids, and organoheterocyclic compounds. The presence of BRAF‐V600E mutations in ameloblastoma was related to decreased levels of glycerol in comparison to tumors carrying only wild‐type alleles of this gene. No metabolic differences were observed between recurrent and primary manifestations of ameloblastoma.
Conclusions
Ameloblastoma exhibits a distinct metabolic profile from normal odontogenic epithelium. BRAF‐V600E may contribute to metabolic alterations in ameloblastoma. Collectively, our findings suggest that metabolic alterations might play a role in tumor pathogenesis.
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Association between geographic tongue and psoriasis. A systematic review and meta‐analyses
Abstract
Geographic tongue (GT) has been described as a predictor of psoriasis. The objective of this study was to analyse the prevalence of GT in psoriatic and non‐psoriatic patients. For this purpose, we conducted a systematic review and meta‐analysis. A literature search was performed on PubMed, Embase, Web of Science and the Cochrane Database of Systematic Reviews. The search and selection process was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) criteria. Only case‐control studies were selected and the prevalence of GT in both groups was compared. Eleven articles met the inclusion criteria and the frequency of GT was statistically associated with psoriasis in ten studies. The pooled odds ratio (OR) was 3.53 (95% confidence interval [CI] 2.56–4.86). There were no significant differences between the presence of GT and the clinical form. However, the Psoriasis Area and Severity Index (PASI) score was statistically higher in patients affected by GT in three of four studies. Psoriatic patients with GT also exhibited less improvement in the PASI score after treatment. One study found an association between GT and a negative impact on patients' quality of life. Nevertheless, age, gender, toxic habits, psoriasis onset and duration of the disease were not clearly associated. The results support the concept of GT as a manifestation of psoriasis. Future research should focus on the repercussions of GT in psoriatic patients, due to the negative consequences on severity and treatment response.
This article is protected by copyright. All rights reserved.
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The importance of BRAF‐V600E mutation to ameloblastoma metabolism
Abstract
Background
Ameloblastoma is a locally infiltrative, aggressive epithelial odontogenic neoplasm. BRAF‐V600E mutation is frequently found in this tumor and has a pivotal role in its pathogenesis, but the consequences of this alteration need to be addressed. An untargeted metabolomics approach was applied to verify whether metabolic disturbances are related to tumor biology and whether BRAF‐V600E mutation contributes to these alterations.
Methods
Formalin‐fixed and paraffin‐embedded tissue specimens from thirteen ameloblastoma and six dental follicles were included in this study. BRAF mutational status was determined by competitive allele‐specific real‐time PCR. Metabolite extracts were analyzed using gas chromatography coupled to mass spectrometry. Univariate and multivariate statistical methods were employed to compare the metabolic profiles of the samples.
Results
The abundance of eleven metabolites were significantly higher in ameloblastoma in relation to dental follicles, including amino acids, fatty acids, carbohydrates, inorganic acids, and organoheterocyclic compounds. The presence of BRAF‐V600E mutations in ameloblastoma was related to decreased levels of glycerol in comparison to tumors carrying only wild‐type alleles of this gene. No metabolic differences were observed between recurrent and primary manifestations of ameloblastoma.
Conclusions
Ameloblastoma exhibits a distinct metabolic profile from normal odontogenic epithelium. BRAF‐V600E may contribute to metabolic alterations in ameloblastoma. Collectively, our findings suggest that metabolic alterations might play a role in tumor pathogenesis.
This article is protected by copyright. All rights reserved.
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Association between geographic tongue and psoriasis. A systematic review and meta‐analyses
Abstract
Geographic tongue (GT) has been described as a predictor of psoriasis. The objective of this study was to analyse the prevalence of GT in psoriatic and non‐psoriatic patients. For this purpose, we conducted a systematic review and meta‐analysis. A literature search was performed on PubMed, Embase, Web of Science and the Cochrane Database of Systematic Reviews. The search and selection process was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) criteria. Only case‐control studies were selected and the prevalence of GT in both groups was compared. Eleven articles met the inclusion criteria and the frequency of GT was statistically associated with psoriasis in ten studies. The pooled odds ratio (OR) was 3.53 (95% confidence interval [CI] 2.56–4.86). There were no significant differences between the presence of GT and the clinical form. However, the Psoriasis Area and Severity Index (PASI) score was statistically higher in patients affected by GT in three of four studies. Psoriatic patients with GT also exhibited less improvement in the PASI score after treatment. One study found an association between GT and a negative impact on patients' quality of life. Nevertheless, age, gender, toxic habits, psoriasis onset and duration of the disease were not clearly associated. The results support the concept of GT as a manifestation of psoriasis. Future research should focus on the repercussions of GT in psoriatic patients, due to the negative consequences on severity and treatment response.
This article is protected by copyright. All rights reserved.
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Juvenile nasopharyngeal angiofibroma: A retrospective study of 27 cases in the ent Department of ipo‐Porto
Abstract
Juvenile nasopharyngeal angiofibroma (JNA) is a benign, rare and highly vascular tumour, occurring in adolescent males.
Clinical records of 27 patients who underwent surgical resection, performed between 1989 and 2017, were reviewed.
Three patients were submitted to paralatero‐nasal rhinotomy, 23 patients (85%), to the sublabial transnasomaxillary approach (Rouge Denker approach), complemented in 19 (70.0%) with transpalatine approach (Wilson technique). Endoscopic resection was performed only at one patient stage IB.
There were no cases of death, major significant complications or significant morbidity. Persistence rate was 18.5% and recurrence rate 14.8%.
Patients with tumour extension to infratemporal fossa and no massive cavernous sinus invasion may be treated effectively without previous embolization and facial scars, with sublabial transnasomaxillary approach (Rouge Denker approach), complemented with transpalatine approach (Wilson technique).
This article is protected by copyright. All rights reserved.
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Juvenile nasopharyngeal angiofibroma: A retrospective study of 27 cases in the ent Department of ipo‐Porto
Abstract
Juvenile nasopharyngeal angiofibroma (JNA) is a benign, rare and highly vascular tumour, occurring in adolescent males.
Clinical records of 27 patients who underwent surgical resection, performed between 1989 and 2017, were reviewed.
Three patients were submitted to paralatero‐nasal rhinotomy, 23 patients (85%), to the sublabial transnasomaxillary approach (Rouge Denker approach), complemented in 19 (70.0%) with transpalatine approach (Wilson technique). Endoscopic resection was performed only at one patient stage IB.
There were no cases of death, major significant complications or significant morbidity. Persistence rate was 18.5% and recurrence rate 14.8%.
Patients with tumour extension to infratemporal fossa and no massive cavernous sinus invasion may be treated effectively without previous embolization and facial scars, with sublabial transnasomaxillary approach (Rouge Denker approach), complemented with transpalatine approach (Wilson technique).
This article is protected by copyright. All rights reserved.
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The Effects of Ozone Therapy on Periodontal Therapy: A Randomized Placebo‐Controlled Clinical Trial
Abstract
Objectives
The aim of this randomized split‐mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non‐surgical periodontal therapy.
Methods
A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm CAL were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non‐surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin‐3 (PTX‐3), interleukin‐1β (IL‐1β) and high sensitivity C‐reactive protein (Hs‐CRP) were evaluated. All statistical data were analyzed using SPSS software.
Results
Total of 36 participants completed the study (18 males, 18 females). PI, GI, PD, percentage of bleeding on probing, percentage of pockets deeper than 5mm and CAL, and percentage of ≥3 mm CAL, were improved, and there were no significant differences between the two sides. All inflammatory parameters, PTX‐3, Hs‐CRP and IL‐1β, were reduced at 3‐months follow‐up. Only the decrease in PTX‐3 levels between baseline and 3‐months follow‐up was statistically significant.
Conclusions
Ozone therapy did not have any additional effect on periodontal parameters. All cytokines were reduced after periodontal therapy. Only PTX‐3 levels were significantly lower at ozone sites compared to those at the control sites.
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Sex Hormone Replacement Therapy in Periodontology – A Systematic Review
Abstract
Objective
To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans.
Materials and Methods
Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/Medline. Human observational and interventional studies that evaluated the following parameters were included: Clinical Attachment Loss (CAL), Probing Pocket Depth (PPD), Bleeding on Probing (BOP), Radiographic Bone Loss (RBL) or osseointegration.
Results
Initial search retrieved 1282 non‐duplicated articles. Fifteen studies were selected after inclusion criteria were applied. All studies were performed in postmenopausal women. Mean differences for PPD reduction ranged from 0.02‐0.2 mm in HRT‐positive patients; mean CAL gain ‐0.18‐0.54 mm; mean RBL reduction ‐0.87‐0.15 mm; and mean BOP reduction 9‐30.3%. Failure rate of dental implants increased ‐5.5‐11.21% when HRT was used.
Conclusions
Very low but consistent evidence suggests a reduction in BOP and no impact on RBL in postmenopausal women receiving HRT. There are inconsistent reports that suggests that HRT in postmenopausal women: 1)improves or does not impact PPD reduction and CAL gain; and 2)does not impact or increase implant loss. In summary, there is no evidence to support HRT prescription for either men or women for periodontal/implant placement purposes.
This article is protected by copyright. All rights reserved.
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The Effects of Ozone Therapy on Periodontal Therapy: A Randomized Placebo‐Controlled Clinical Trial
Abstract
Objectives
The aim of this randomized split‐mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non‐surgical periodontal therapy.
Methods
A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm CAL were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non‐surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin‐3 (PTX‐3), interleukin‐1β (IL‐1β) and high sensitivity C‐reactive protein (Hs‐CRP) were evaluated. All statistical data were analyzed using SPSS software.
Results
Total of 36 participants completed the study (18 males, 18 females). PI, GI, PD, percentage of bleeding on probing, percentage of pockets deeper than 5mm and CAL, and percentage of ≥3 mm CAL, were improved, and there were no significant differences between the two sides. All inflammatory parameters, PTX‐3, Hs‐CRP and IL‐1β, were reduced at 3‐months follow‐up. Only the decrease in PTX‐3 levels between baseline and 3‐months follow‐up was statistically significant.
Conclusions
Ozone therapy did not have any additional effect on periodontal parameters. All cytokines were reduced after periodontal therapy. Only PTX‐3 levels were significantly lower at ozone sites compared to those at the control sites.
This article is protected by copyright. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RSAPhV
Sex Hormone Replacement Therapy in Periodontology – A Systematic Review
Abstract
Objective
To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans.
Materials and Methods
Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/Medline. Human observational and interventional studies that evaluated the following parameters were included: Clinical Attachment Loss (CAL), Probing Pocket Depth (PPD), Bleeding on Probing (BOP), Radiographic Bone Loss (RBL) or osseointegration.
Results
Initial search retrieved 1282 non‐duplicated articles. Fifteen studies were selected after inclusion criteria were applied. All studies were performed in postmenopausal women. Mean differences for PPD reduction ranged from 0.02‐0.2 mm in HRT‐positive patients; mean CAL gain ‐0.18‐0.54 mm; mean RBL reduction ‐0.87‐0.15 mm; and mean BOP reduction 9‐30.3%. Failure rate of dental implants increased ‐5.5‐11.21% when HRT was used.
Conclusions
Very low but consistent evidence suggests a reduction in BOP and no impact on RBL in postmenopausal women receiving HRT. There are inconsistent reports that suggests that HRT in postmenopausal women: 1)improves or does not impact PPD reduction and CAL gain; and 2)does not impact or increase implant loss. In summary, there is no evidence to support HRT prescription for either men or women for periodontal/implant placement purposes.
This article is protected by copyright. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WUapzP
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