Δευτέρα 29 Οκτωβρίου 2018

Maribel ’ s Sweets Inc. Allergy Alert on Undeclared Milk Allergens in Chocolate Bars

Maribel ' s Sweets Inc. of Brooklyn, NY is recalling its 2.82oz MarieBelle Japanese Matcha Japanese Green Tea and White Chocolate Bar, container code 101619, Cacao Market by MarieBelle Rosemary Truffle Salt 60% Dark Chocolate Bar, all container codes, and the Cacao Market by MarieBelle Orange Peels 60% Dark Chocolate Bar, all container codes, because they may contain undeclared milk allergens. Consumers who are allergic to milk allergens may run the risk of serious or life-threatening allergic reactions if they consume this product. (Source: Food and Drug Administration)

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Maribel ’ s Sweets Inc. Allergy Alert on Undeclared Milk Allergens in Chocolate Bars

Maribel ' s Sweets Inc. of Brooklyn, NY is recalling its 2.82oz MarieBelle Japanese Matcha Japanese Green Tea and White Chocolate Bar, container code 101619, Cacao Market by MarieBelle Rosemary Truffle Salt 60% Dark Chocolate Bar, all container codes, and the Cacao Market by MarieBelle Orange Peels 60% Dark Chocolate Bar, all container codes, because they may contain undeclared milk allergens. Consumers who are allergic to milk allergens may run the risk of serious or life-threatening allergic reactions if they consume this product. (Source: Food and Drug Administration)

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Cross-Sectional Survey of Plasmodium and Other Parasites in Pregnant Women and Children Around Margibi and Montserrado Counties, Liberia

Condition:   Malaria Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Endocrine Immunology in Early Stage ER+ Breast Cancer Patients

Conditions:   Breast Cancer;   Estrogen Receptor-positive Breast Cancer;   Healthy Intervention:   Sponsors:   Duke University;   United States Department of Defense Not yet recruiting (Source: ClinicalTrials.gov)

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Investigational Therapeutics for the Treatment of People With Ebola Virus Disease

Condition:   Ebola Virus Interventions:   Drug: ZMapp;   Drug: Remdesivir;   Drug: MAb114 Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis

Conditions:   Gingivitis;   Mucositis Intervention:   Behavioral: Experimentally induced plaque Sponsor:   University of Campinas, Brazil Completed (Source: ClinicalTrials.gov)

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Identification by Cytometry by Mass of Predictive Immunological Profiles of Answer to Treatmentby Biotherapics for Patients With Crohn's Disease

Condition:   Crohn Disease Interventions:   Drug: Anti-TNF Drug;   Drug: Ustekinumab Sponsor:   Hospices Civils de Lyon Not yet recruiting (Source: ClinicalTrials.gov)

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Hairy polyps: A new case presentation and a pathogenetic hypothesis

The Laryngoscope, EarlyView.


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Drought in the Semiarid Region of Brazil: Exposure, Vulnerabilities and Health Impacts from the Perspectives of Local Actors

Conclusion The results obtained from this research shows, in general, the fragility in the social and political infrastructure necessary to improve the living conditions of populations, particularly those that depend on family agriculture in drought prone areas. The conditions of social, economic and environmental vulnerabilities presented in the region can be amplified by the drought process, and can aggravate the impacts resulting drought events, thus disadvantaging the population of this region, as shown in the Fig. 1. The general perception of the interviewees of the health sector shows an agreement with what is found in the literature on the relationship between drought and health conditions. However, the lack of specific knowledge regarding the relation between drought and health, b...

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Phase 1 Clinical Trial of Single-Vial ID93 + GLA-SE in Healthy Adults

Condition:   Pulmonary TB Intervention:   Biological: ID93 + GLA-SE Sponsors:   IDRI;   National Institutes of Health (NIH);   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Cross-Sectional Survey of Plasmodium and Other Parasites in Pregnant Women and Children Around Margibi and Montserrado Counties, Liberia

Condition:   Malaria Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rl0wrm

Endocrine Immunology in Early Stage ER+ Breast Cancer Patients

Conditions:   Breast Cancer;   Estrogen Receptor-positive Breast Cancer;   Healthy Intervention:   Sponsors:   Duke University;   United States Department of Defense Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PqGazT

Investigational Therapeutics for the Treatment of People With Ebola Virus Disease

Condition:   Ebola Virus Interventions:   Drug: ZMapp;   Drug: Remdesivir;   Drug: MAb114 Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RlFdpG

Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis

Conditions:   Gingivitis;   Mucositis Intervention:   Behavioral: Experimentally induced plaque Sponsor:   University of Campinas, Brazil Completed (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PwQeHi

Identification by Cytometry by Mass of Predictive Immunological Profiles of Answer to Treatmentby Biotherapics for Patients With Crohn's Disease

Condition:   Crohn Disease Interventions:   Drug: Anti-TNF Drug;   Drug: Ustekinumab Sponsor:   Hospices Civils de Lyon Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RnwCTl

Hairy polyps: A new case presentation and a pathogenetic hypothesis

The Laryngoscope, EarlyView.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpiITF

Drought in the Semiarid Region of Brazil: Exposure, Vulnerabilities and Health Impacts from the Perspectives of Local Actors

Conclusion The results obtained from this research shows, in general, the fragility in the social and political infrastructure necessary to improve the living conditions of populations, particularly those that depend on family agriculture in drought prone areas. The conditions of social, economic and environmental vulnerabilities presented in the region can be amplified by the drought process, and can aggravate the impacts resulting drought events, thus disadvantaging the population of this region, as shown in the Fig. 1. The general perception of the interviewees of the health sector shows an agreement with what is found in the literature on the relationship between drought and health conditions. However, the lack of specific knowledge regarding the relation between drought and health, b...

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Endoscopic Transcanal Autologous Cartilage Ossiculoplasty

Abstract

This was a randomized clinical trial, of thirty-two patients undergoing endoscopic ossiculoplasty, as a second look surgery, at 6 months after primary endoscopic cholesteatoma surgery, in a duration of 9 years. All patients underwent trans-canal endoscopic ossiculoplasty under local anesthesia. Prosthesis used were (1) Titanium partial ossicular replacement prosthesis (PORP) in fourteen, (2) Titanium total ossicular replacement prosthesis (TORP) in six and (3) Autologous cartilage in twelve cases. Puretone audiometry (PTA) were done preoperatively and postoperatively at 2 months and 3 years. Out of twenty-four cases, which presented only with stapes superstructure; fourteen underwent PORP ossiculoplasty and twelve had cartilage short columella ossiculoplasty (SCC). Out of eight cases, which had only mobile stapes footplate, six underwent TORP ossiculoplasty and only two underwent long columella cartilage ossiculoplasty (LCC). Pre-operative average air conduction threshold (AC) of pure tone audiometry were 45.47 dB (PORP), 66.10 dB (TORP), 49.15 dB (SCC) and 59.15 dB (LCC) groups. The post-operative AC at 2 months were respectively 27.37 dB (PORP), 45.83 dB (TORP), 29.99 dB (SCC) and 39.15 dB (LCC) groups. The gap of air and bone conduction (ABG) at 2 months post-operative stage were 19.05 dB (PORP), 20 dB (TORP), 20.32 dB (SCC) and 39.15 dB (LCC) groups and not much changed after 3 years. Extrusion occurred in three PORPs and four TORPs at 4–8 years after surgery. Four cases were lost to follow up. No extrusion occurred in cartilage ossiculoplasty. Trans-canal endoscopic autologous cartilage ossiculoplasty shows encouraging results comparable to titanium prosthesis in repairing ossicles in cholesteatoma disease.



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Submental Ectopic Thyroid Cyst: An Atypical Presentation

Abstract

It is very unusual of an ectopic thyroid to be presented as a submental swelling, clinically mimicking a submental cyst. Suspicious of the disease with complete clinical, biochemical and radiological correlation is the mainstay of diagnosis as the first FNAC is not confirmatory of the ectopic thyroid especially in cases of dysgenesis of thyroid tissue in an unusual location. Here we have presented a rare case of an ectopic thyroid gland presented with a submental swelling successfully managed with the conservative treatment.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zfZ3Ls

Endoscopic Transcanal Autologous Cartilage Ossiculoplasty

Abstract

This was a randomized clinical trial, of thirty-two patients undergoing endoscopic ossiculoplasty, as a second look surgery, at 6 months after primary endoscopic cholesteatoma surgery, in a duration of 9 years. All patients underwent trans-canal endoscopic ossiculoplasty under local anesthesia. Prosthesis used were (1) Titanium partial ossicular replacement prosthesis (PORP) in fourteen, (2) Titanium total ossicular replacement prosthesis (TORP) in six and (3) Autologous cartilage in twelve cases. Puretone audiometry (PTA) were done preoperatively and postoperatively at 2 months and 3 years. Out of twenty-four cases, which presented only with stapes superstructure; fourteen underwent PORP ossiculoplasty and twelve had cartilage short columella ossiculoplasty (SCC). Out of eight cases, which had only mobile stapes footplate, six underwent TORP ossiculoplasty and only two underwent long columella cartilage ossiculoplasty (LCC). Pre-operative average air conduction threshold (AC) of pure tone audiometry were 45.47 dB (PORP), 66.10 dB (TORP), 49.15 dB (SCC) and 59.15 dB (LCC) groups. The post-operative AC at 2 months were respectively 27.37 dB (PORP), 45.83 dB (TORP), 29.99 dB (SCC) and 39.15 dB (LCC) groups. The gap of air and bone conduction (ABG) at 2 months post-operative stage were 19.05 dB (PORP), 20 dB (TORP), 20.32 dB (SCC) and 39.15 dB (LCC) groups and not much changed after 3 years. Extrusion occurred in three PORPs and four TORPs at 4–8 years after surgery. Four cases were lost to follow up. No extrusion occurred in cartilage ossiculoplasty. Trans-canal endoscopic autologous cartilage ossiculoplasty shows encouraging results comparable to titanium prosthesis in repairing ossicles in cholesteatoma disease.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SuJM2j

Submental Ectopic Thyroid Cyst: An Atypical Presentation

Abstract

It is very unusual of an ectopic thyroid to be presented as a submental swelling, clinically mimicking a submental cyst. Suspicious of the disease with complete clinical, biochemical and radiological correlation is the mainstay of diagnosis as the first FNAC is not confirmatory of the ectopic thyroid especially in cases of dysgenesis of thyroid tissue in an unusual location. Here we have presented a rare case of an ectopic thyroid gland presented with a submental swelling successfully managed with the conservative treatment.



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The 2018 Nobel Prize in Physiology or Medicine: An exemplar of Bench to Bedside in Immunology

(Source: Journal of Allergy and Clinical Immunology)

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Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients

The inability to resolve Coccidioides infection correlates with elevated Treg frequency and functional marker expression at diagnosis. Treg frequency may be a diagnostic for calibrating treatment aggressiveness for patients likely to develop chronic cocciodiomycosis. (Source: Journal of Allergy and Clinical Immunology)

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The 2018 Nobel Prize in Physiology or Medicine: An exemplar of Bench to Bedside in Immunology

(Source: Journal of Allergy and Clinical Immunology)

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MicroRNA-146b-3p Promotes Cell Metastasis by Directly Targeting NF2 in Human Papillary Thyroid Cancer

Thyroid, Ahead of Print.


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MicroRNA-146b-3p Promotes Cell Metastasis by Directly Targeting NF2 in Human Papillary Thyroid Cancer

Thyroid, Ahead of Print.


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Constrained least square nonuniform dynamic filter bank for delay and Hardware efficient digital hearing aids

AbstractHearing aid design requires a set of filters that provides reasonable audiogram matching for the specific type of hearing loss. Various fixed and reconfigurable filter banks are reported for different sound wave decomposition plans. But the delay and complexity of these structures are relatively large for a real hearing aid system. In this paper, a constrained least square, finite impulse response filter bank with low group delay and low hardware complexity is proposed. The method has considerable reduction in multiplications per sample and is more suitable for systems where the spectra of desired and undesired signals are overlapped. Coefficient decimation technique is used to vary the edge frequencies of the filters to make the system dynamic to accommodate the changes which can ...

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Hearing impairment and hypoxia ischaemic encephalopathy: Incidence and associated factors.

CONCLUSION: This study confirms that hearing impairment is common in term infants who have undergone therapeutic hypothermia for moderate/severe HIE. Blood glucose should be monitored carefully in these infants and developmental surveillance should include formal audiology. Further larger studies are needed to clarify the role, if any, of hypothermia per se in causation of hearing loss and to fully identify risk factors for hearing impairment in this population. WHAT IS NEW: The current study confirms that hearing impairment is common in term infants who have undergone therapeutic hypothermia for moderate/severe HIE. No association between gentamicin use and the development of hearing impairment was found however initial blood glucose outside the normal range was of significance. Other...

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Constrained least square nonuniform dynamic filter bank for delay and Hardware efficient digital hearing aids

AbstractHearing aid design requires a set of filters that provides reasonable audiogram matching for the specific type of hearing loss. Various fixed and reconfigurable filter banks are reported for different sound wave decomposition plans. But the delay and complexity of these structures are relatively large for a real hearing aid system. In this paper, a constrained least square, finite impulse response filter bank with low group delay and low hardware complexity is proposed. The method has considerable reduction in multiplications per sample and is more suitable for systems where the spectra of desired and undesired signals are overlapped. Coefficient decimation technique is used to vary the edge frequencies of the filters to make the system dynamic to accommodate the changes which can ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yF7Pn8

Hearing impairment and hypoxia ischaemic encephalopathy: Incidence and associated factors.

CONCLUSION: This study confirms that hearing impairment is common in term infants who have undergone therapeutic hypothermia for moderate/severe HIE. Blood glucose should be monitored carefully in these infants and developmental surveillance should include formal audiology. Further larger studies are needed to clarify the role, if any, of hypothermia per se in causation of hearing loss and to fully identify risk factors for hearing impairment in this population. WHAT IS NEW: The current study confirms that hearing impairment is common in term infants who have undergone therapeutic hypothermia for moderate/severe HIE. No association between gentamicin use and the development of hearing impairment was found however initial blood glucose outside the normal range was of significance. Other...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OfHLnd

MicroRNA-146b-3p Promotes Cell Metastasis by Directly Targeting NF2 in Human Papillary Thyroid Cancer

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zdCN55

MicroRNA-146b-3p Promotes Cell Metastasis by Directly Targeting NF2 in Human Papillary Thyroid Cancer

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zdCN55

MicroRNA-146b-3p Promotes Cell Metastasis by Directly Targeting NF2 in Human Papillary Thyroid Cancer

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6zJPA

MicroRNA-146b-3p Promotes Cell Metastasis by Directly Targeting NF2 in Human Papillary Thyroid Cancer

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6zJPA

Development and psychometric properties of the methamphetamine decisional balance scale (METH-DBS) for young adults

Drug misuse is a major problem that has an extreme negative effect on people's health. Methamphetamine (MA) is frequently used by young adults, despite its harmful consequences. The Transtheoretical Model (TTM...

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Development and psychometric properties of the methamphetamine decisional balance scale (METH-DBS) for young adults

Drug misuse is a major problem that has an extreme negative effect on people's health. Methamphetamine (MA) is frequently used by young adults, despite its harmful consequences. The Transtheoretical Model (TTM...

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Schistosoma “Eggs-Iting” the Host: Granuloma Formation and Egg Excretion

Christian Schwartz, Padraic G. Fallon (Source: Frontiers in Immunology)

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Engineering CAR-T Cells for Improved Function Against Solid Tumors

Michael A. Morgan, Axel Schambach (Source: Frontiers in Immunology)

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Coinfection With Influenza A Virus and Klebsiella oxytoca: An Underrecognized Impact on Host Resistance and Tolerance to Pulmonary Infections

Kayla M. Lee, Jenna Morris-Love, Damien J. Cabral, Peter Belenky, Steven M. Opal, Amanda M. Jamieson (Source: Frontiers in Immunology)

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21 ‐hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I

Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)

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Tape stripping alters the microbe ‐host correlations in mouse skin

Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)

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Impact of community respiratory viral infections in urban children with asthma

Upper respiratory tract viral infections cause asthma exacerbations in children. However, the impact of natural colds on asthmatic children in the community, particularly in the high-risk urban environment, is less well-defined. (Source: Annals of Allergy, Asthma and Immunology)

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Schistosoma “Eggs-Iting” the Host: Granuloma Formation and Egg Excretion

Christian Schwartz, Padraic G. Fallon (Source: Frontiers in Immunology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ss7ex7

Engineering CAR-T Cells for Improved Function Against Solid Tumors

Michael A. Morgan, Axel Schambach (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z8vkUI

Coinfection With Influenza A Virus and Klebsiella oxytoca: An Underrecognized Impact on Host Resistance and Tolerance to Pulmonary Infections

Kayla M. Lee, Jenna Morris-Love, Damien J. Cabral, Peter Belenky, Steven M. Opal, Amanda M. Jamieson (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ss79JP

21 ‐hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I

Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zcKTea

Tape stripping alters the microbe ‐host correlations in mouse skin

Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ss73St

Impact of community respiratory viral infections in urban children with asthma

Upper respiratory tract viral infections cause asthma exacerbations in children. However, the impact of natural colds on asthmatic children in the community, particularly in the high-risk urban environment, is less well-defined. (Source: Annals of Allergy, Asthma and Immunology)

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FDA to launch warning labels for sesame seeds as rate of allergies soars

More than 300,000 Americans are allergic to sesame, data suggest. It is now on par with fish and soy allergies, a huge increase in 20 years. Now, the FDA is taking action. (Source: the Mail online | Health)

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FDA to launch warning labels for sesame seeds as rate of allergies soars

More than 300,000 Americans are allergic to sesame, data suggest. It is now on par with fish and soy allergies, a huge increase in 20 years. Now, the FDA is taking action. (Source: the Mail online | Health)

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The Effect of Anaesthetic and Analgesic Technique on Oncological Outcomes

Abstract

Purpose of Review

The purpose of this review is to provide an examination of the recent literature relating to anaesthesia and analgesia for cancer surgery and their potential effects on cancer recurrence and metastasis.

Recent Findings

Opioids continue to have mixed results in terms of their long-term effects on cancer outcomes. While laboratory evidence suggests alterations in immune responses and pro-tumourigenic effects via opioid receptors on cancer cells, clinical evidence is lacking. Regional anaesthesia has the ability to regulate surgical stress response, but retrospective studies provide conflicting results. However, lidocaine appears to have protective functions against cancer and anti-inflammatory properties making it a potentially useful agent perioperatively. An association also exists between the use of non-steroidal anti-inflammatory agents and improved perioperative outcomes; however, prospective clinical studies are required to provide more robust data in this area. Inhalational agents appear to confer increased risk of cancer recurrence in comparison to total intravenous anaesthesia (TIVA). A recent large retrospective trial and in vivo and in vitro evidence point to a beneficial effect of TIVA versus volatiles that should be fully investigated.

Summary

Retrospective analysis provides tenuous links between the techniques used perioperatively and potential cancer recurrence and metastasis. In vitro and in vivo animal studies have furthered research in the area, particularly providing mechanisms on how commonly used agents can affect patient outcomes. However, large prospective randomised control trials are required in this area to further the research on anaesthesia and its effects on cancer recurrence and metastasis.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yI4Ud9

Influence of ambient air pressure changes on vestibular symptoms after stapes surgery

To examine if vestibular irritation after stapes surgery may be provoked by pressure changes across the tympanic membrane, which consecutively results in displacements of the ossicular chain and the piston prosthesis suspended to it.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2COVoYs

The Effect of Anaesthetic and Analgesic Technique on Oncological Outcomes

Abstract

Purpose of Review

The purpose of this review is to provide an examination of the recent literature relating to anaesthesia and analgesia for cancer surgery and their potential effects on cancer recurrence and metastasis.

Recent Findings

Opioids continue to have mixed results in terms of their long-term effects on cancer outcomes. While laboratory evidence suggests alterations in immune responses and pro-tumourigenic effects via opioid receptors on cancer cells, clinical evidence is lacking. Regional anaesthesia has the ability to regulate surgical stress response, but retrospective studies provide conflicting results. However, lidocaine appears to have protective functions against cancer and anti-inflammatory properties making it a potentially useful agent perioperatively. An association also exists between the use of non-steroidal anti-inflammatory agents and improved perioperative outcomes; however, prospective clinical studies are required to provide more robust data in this area. Inhalational agents appear to confer increased risk of cancer recurrence in comparison to total intravenous anaesthesia (TIVA). A recent large retrospective trial and in vivo and in vitro evidence point to a beneficial effect of TIVA versus volatiles that should be fully investigated.

Summary

Retrospective analysis provides tenuous links between the techniques used perioperatively and potential cancer recurrence and metastasis. In vitro and in vivo animal studies have furthered research in the area, particularly providing mechanisms on how commonly used agents can affect patient outcomes. However, large prospective randomised control trials are required in this area to further the research on anaesthesia and its effects on cancer recurrence and metastasis.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yI4Ud9

Influence of ambient air pressure changes on vestibular symptoms after stapes surgery

To examine if vestibular irritation after stapes surgery may be provoked by pressure changes across the tympanic membrane, which consecutively results in displacements of the ossicular chain and the piston prosthesis suspended to it.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2COVoYs

FDA to launch warning labels for sesame seeds as rate of allergies soars

More than 300,000 Americans are allergic to sesame, data suggest. It is now on par with fish and soy allergies, a huge increase in 20 years. Now, the FDA is taking action. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qhOxPS

FDA to launch warning labels for sesame seeds as rate of allergies soars

More than 300,000 Americans are allergic to sesame, data suggest. It is now on par with fish and soy allergies, a huge increase in 20 years. Now, the FDA is taking action. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



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Personalisierte Prävention allergischer Erkrankungen



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Asthma hat viele Gesichter

Unter dem Begriff Asthma werden heute eine Reihe unterschiedlicher Phänotypen der entzündlichen Atemwegserkrankung zusammengefasst. Den Grundstein für diese Entwicklung legte vor 100 Jahren der Mediziner Francis M. Rackemann.



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„Für eine Welt ohne Allergien“

So weit, wie das ambitionierte Motto des 13. Deutschen Allergiekonkresses erahnen lassen könnte, ist es leider noch lange nicht. Doch wie man diesem bislang noch weit entfernten Ziel ein Stück näher kommen könnte, wurde Ende September in Dresden diskutiert. Behandelte Themen waren unter anderem die personalisierte Allergieprävention, Defizite in der Anapylaxietherapie und seltene allergische Erkrankungen.



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13. Deutscher Allergiekongress — ein Rückblick in Bildern



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Kombiniert oder einzeln — jetzt wieder erstattungsfähig!

Nicht verschreibungspflichtige nasale Glukokortikoide mit den Wirkstoffen Beclomethason, Fluticason und Mometason können inzwischen wieder auf Kassenrezept verordnet werden. Dies gilt auch für ein Kombinationspräparat aus nasalem Glukokortikoid und Antihistaminikum, wie der Ärzteverband Deutscher Allergologen klarstellt.



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Elektronische Abstracteinreichung Schritt für Schritt



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Basophilenaktivierungstest zur Diagnose von Sesamallergie

Für Menschen mit einer Allergie gegen Sesam können bereits Spuren von selbigem eine schwere anaphylaktische Reaktion auslösen. Doch bislang gibt es keine ideale Methode, mit der eine Sesamallergie zuverlässig und risikofrei diagnostiziert werden kann.



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Allergie im Fokus: ASIT und Biologika — „State of the ART“



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Seltene allergische Erkrankungen



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Minorallergene bei Walnussallergie relevant

Untersucht man Walnussallergiker mit Walnuss-ImmunoCAP-Extrakt, reagieren nicht alle Seren. Ein Grund könnten fehlende Minorallergene wie das Jug r 4 sein. Eine Laborstudie ging der Frage nach.



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Gezielte Exposition versus Allergenmeidung



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Einladung zur DGAKI-Frühjahrstagung



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Neuer Pfeil im Therapieköcher gegen Asthma von Kindern

Die Palette von Medikamenten für die Kontrolle von Asthma im Kindesalter hat Zuwachs bekommen: Der langwirksame Muskarinantagonist Tiotropium ergänzt die Optionen für die Add-on-Therapie.



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Allergologie unter Druck



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Personalisierte Prävention allergischer Erkrankungen



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P14oRX

Asthma hat viele Gesichter

Unter dem Begriff Asthma werden heute eine Reihe unterschiedlicher Phänotypen der entzündlichen Atemwegserkrankung zusammengefasst. Den Grundstein für diese Entwicklung legte vor 100 Jahren der Mediziner Francis M. Rackemann.



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13. Deutscher Allergiekongress — ein Rückblick in Bildern



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Spezifische Immuntherapie: Warnung vor unbedachter Anwendung



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Kombiniert oder einzeln — jetzt wieder erstattungsfähig!

Nicht verschreibungspflichtige nasale Glukokortikoide mit den Wirkstoffen Beclomethason, Fluticason und Mometason können inzwischen wieder auf Kassenrezept verordnet werden. Dies gilt auch für ein Kombinationspräparat aus nasalem Glukokortikoid und Antihistaminikum, wie der Ärzteverband Deutscher Allergologen klarstellt.



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Arzneimittelallergie bei Kindern und Jugendlichen



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Elektronische Abstracteinreichung Schritt für Schritt



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Akupunktur bei allergischen Erkrankungen — wann ist sie sinnvoll?



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Das Curriculum der deutschen Allergologie in einem Kurs



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Basophilenaktivierungstest zur Diagnose von Sesamallergie

Für Menschen mit einer Allergie gegen Sesam können bereits Spuren von selbigem eine schwere anaphylaktische Reaktion auslösen. Doch bislang gibt es keine ideale Methode, mit der eine Sesamallergie zuverlässig und risikofrei diagnostiziert werden kann.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CSnj9U

Allergie im Fokus: ASIT und Biologika — „State of the ART“



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OXAjCp

Seltene allergische Erkrankungen



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CR8JzQ

Minorallergene bei Walnussallergie relevant

Untersucht man Walnussallergiker mit Walnuss-ImmunoCAP-Extrakt, reagieren nicht alle Seren. Ein Grund könnten fehlende Minorallergene wie das Jug r 4 sein. Eine Laborstudie ging der Frage nach.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P1y94P

Gezielte Exposition versus Allergenmeidung



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CQoWoT

Einladung zur DGAKI-Frühjahrstagung



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Management of an avulsed tooth during the placement of a laryngeal mask airway

At the start of a full dental clearance under general anaesthetic, the surgical team noted an avulsed lower left central incisor with an empty bleeding socket, but the anaesthetic team was unaware of it. The tooth was crowned, grade III mobile, and had been checked by the surgeons, but not the anaesthetic team, preoperatively.

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Management of an avulsed tooth during the placement of a laryngeal mask airway

At the start of a full dental clearance under general anaesthetic, the surgical team noted an avulsed lower left central incisor with an empty bleeding socket, but the anaesthetic team was unaware of it. The tooth was crowned, grade III mobile, and had been checked by the surgeons, but not the anaesthetic team, preoperatively.

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Academic integrity and plagiarism: The new regulations in India

Dinesh Kadam

Indian Journal of Plastic Surgery 2018 51(2):109-110



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Shaping the nasal tip: A new approach to transdomal suturing

Argyro Kypraiou, Petros V Vlastarakos, Stefanos Papailiadis

Indian Journal of Plastic Surgery 2018 51(2):247-248



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Dr. Anil Chadha

Ayyappan Thangavel

Indian Journal of Plastic Surgery 2018 51(2):111-114



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Aesthetic subunits of the trunk: Anatomy and behavior of skin and adipose tissue in each unit for better outcomes in liposuction

Sanjay Parashar, Aniketh Venkataram

Indian Journal of Plastic Surgery 2018 51(2):115-122

Background: Liposuction and abdominal contouring is one of the most common procedures performed by plastic surgeons worldwide. Surprisingly, there has been few attempts at dividing the abdomen into subunits to delineate and aid in this endeavour. We have evolved a system of abdominal aesthetic subunits which has enabled us to achieve high quality results. Materials and Methods: A system of 8 subunits of the abdomen was evolved after analysing 1000 cases: Upper midline, upper rectus, lower rectus, pubic, Lateral abdomen, Lumbar Posterior midline and Bra Roll. Results: The system was used in 2000 cases with good results. The system enabled the performance of tailored liposuction in each area, with greater accuracy, better results and fewer complications. Conclusion: Our success with this classification validates its use, and makes liposuction more scientific and effective.

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Fixators to retractors: Use of k-wires and glove rings as self-retaining retractors

Narayanamurthy Sundaramurthy, Manimaran Ramachandran, Surya Rao Rao Venkata Mahipathy, Alagar Raja Durairaj, Praveen Ganesh Natarajan

Indian Journal of Plastic Surgery 2018 51(2):254-255



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Adipofascial perforator flaps: Its role in reconstruction of soft-tissue defects of lower leg and ankle

Deepak Nanda, Shamendra Anand Sahu, Durga Karki, Sanjay Kumar, Amrita Mandal

Indian Journal of Plastic Surgery 2018 51(2):216-221

Background: Despite advances in surgical skills, adipofascial flaps are still less preferred option for coverage of leg defect. We evaluate the use of perforator-based adipofascial flap in small-to-medium-sized soft-tissue defects in the lower limb. Patients and Methods: After localisation of perforators along the major axial vessels in the lower limb using handheld Doppler, adipofascial flap based on the nearest best perforator of anterior tibial artery, posterior tibial artery and peroneal artery was raised to cover soft-tissue defect in 21 patients. The flap was transposed over the defect and covered by split-skin graft. Donor site was primarily closed. Flap complications, functional and aesthetic outcomes are noted in follow-up. Results: There was partial loss of flap in five patients. After debridement and dressings, split-skin grafting was done for four patients and one patient was managed with local flap. Scar over the flap was stable with no reports of recurrent ulceration or breakdown of wound in 6-month follow-up. Four of five patients reported adequate healing of the fractured bone. Average visual analogue score was 8.24/10 for appearance of donor site as evaluated by the patient. Conclusions: Perforator-based adipofascial flap is a good alternative for coverage of small-to-medium-sized soft-tissue defect of the leg, particularly over the malleolus and lower part of the leg. Use of adipofascial tissue and primary closure of the donor site causes minimal donor-site morbidity. Adipofascial perforator flap provides aesthetically superior recipient-site scar with satisfactory functional outcome.

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The refinement of the median tubercle of cleft lip

Jyotsna Murthy

Indian Journal of Plastic Surgery 2018 51(2):131-136

Aim: Repair of cleft lip aims to bring symmetry and provide normal aesthetics for the lip. Several techniques have been employed; however, the finer aspect of median lip tubercle has not been emphasised in cleft lip repair. Materials and Methods: We have modified cleft lip repair, both unilateral and bilateral, preserving all the tissues of the median tubercle to provide normal-looking median tubercle of the lip. The modified technique was carried out by a single surgeon on 322 cases of unilateral cleft lip and 68 cases of bilateral cleft lip. Follow-up was done for 1–3 years on these children to evaluate the outcome. Results: The evaluation showed excellent results in more than 80% of patients in unilateral cleft lip repair, on 1–3 years of follow-up; 20% had acceptable results. Of 68 patients with bilateral cleft lip, none had any complication, and excellent results were obtained in 70%. Result was rated acceptable in 30%; 15% may need revision surgery for white roll and vermilion adjustment. Conclusion: We present the technique of reconstructing a normal-looking median tubercle in cleft lip repair. The technique was modified based on the study of normal upper lip and embryology of cleft lip, with emphasis on creating better median tubercle of the lip.

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Birth palsy in congenital varicella syndrome: A lesson in anatomy

Ajeesh Sankaran, Praveen Bhardwaj, Hari Venkatramani, Shanmuganathan Raja Sabapathy

Indian Journal of Plastic Surgery 2018 51(2):238-242

While brachial plexus palsy sustained due to birth trauma is well known, congenital palsies are decidedly rare. We report such a case caused by congenital varicella syndrome, with associated congenital Horner's syndrome and heterochromia iridis. The surprising juxtaposition of a classic upper plexus palsy and a Horner's syndrome raises points of interest. Similar reports in literature are reviewed, and the genesis of a very characteristic group of findings is discussed.

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Autologous fat grafting in the treatment of velopharyngeal insufficiency: Clinical outcomes and treatment tolerability survey in a case series of 21 patients

Renzo Panizza, Marco Ghiglione, Enrico Maria Zingarelli, Michela Massa, Claudio Carlini, Rossella Arnoldi, Alessio Pini Prato, Silvia Scarrone, Francesco Vaccarella

Indian Journal of Plastic Surgery 2018 51(2):145-154

Introduction: Velopharyngeal insufficiency (VPI) is the inability to close the velopharyngeal sphincter during phonation and/or feeding. VPI is clinically characterised by hypernasal speech and nasal regurgitation. In cases of severe VPI, pharyngoplasty is recommended. Cases of mild-to-moderate VPI can be treated with fat grafting of the posterior pharyngeal wall in addition to speech therapy. The lipofilling can also be useful after pharyngoplasty to improve the outcomes. Materials and Methods: Twenty-one patients (14 males and 7 females), ages 4–23 affected by mild-to-moderate VPI and treated with lipofilling were included in this retrospective study. The mean injected fat volume was 7.95 cc (median 6 cc, min 4 cc, max 20 cc and range 16 cc). The follow-up ranged from 6 to 60 months. The pre- and post-operative Borel–Maisonny scores were compared using Wilcoxon test. Moreover, we performed a telephone survey with the aim to assess the parental perception on child's speech and quality of life after the surgical treatment. Results: Despite the small sample size, in this case series, we observed a statistically significant Borel–Maisonny score improvement and a parental satisfaction rate of about 85%. Conclusions: The augmentation of the posterior pharyngeal wall in addition to speech therapy improved the Borel–Maisonny score and the intelligibility of this case series of patients affected by mild-to-moderate VPI. In these patients, evaluated in a multidisciplinary approach, this technique allowed us to avoid major surgical procedures that would modify the anatomy of the velopharyngeal port. However, prospective comparative studies or randomised controlled trials could be useful to compare fat grafting with velopharyngoplasty techniques, with the aim to clarify indications and to define a specific treatment protocol.

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Essentials of aesthetic surgery Jeffery J. Janis

Surajit Bhattacharya

Indian Journal of Plastic Surgery 2018 51(2):258-259



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Application of embryonic equivalents in male-to-female sex reassignment surgery

Balakrishnan Margabandu Thalaivirithan, Maithreyi Sethu, Dinesh Karuvakkurichi Ramachandran, Mahadevan Kandasamy, Jaganmohan Janardhanam

Indian Journal of Plastic Surgery 2018 51(2):155-166

Introduction: The feeling of incongruence between phenotypic sex and psychological recognition of self-gender is termed gender dysphoria. Transsexualism is the most extreme form of this disorder. Aims and Objectives: The aims and objectives of the study are to evaluate the esthetic and functional outcome of embryonic equivalents-based male-to-female sex reassignment surgery in transwomen using the institutional scoring system. Materials and Methods: Thirty transwomen who had undergone male-to-female embryonic equivalents-based sex reassignment surgery (MFEEbSRS) from October 2012 to March 2016 were retrospectively studied. The outcome was evaluated by two independent plastic surgeons, based on interview with the individuals, visual assessment, and measurements. Surgical Technique: Clitoris was created from reduced glans on dorsal penile pedicle mounted on the crura of the conjoined corpora cavernosa. De-gloved unfurled proximal penile skin formed the introitus, hood for clitoris and labia minora. Neo-external urethral meatus was fashioned from the distal portion of the bulbar urethra. Distal de-gloved inverted penile tube flap was used for the creation of neovagina. Reduced scrotal flaps formed the labia majora. Observation and Results: The maximum length of neovagina in the study was 12 cm, and the average length was 9.8 cm. Based on our institutional scoring system for the assessment of esthetic and functional outcome, we got excellent results in all transwomen. Conclusion: The esthetic and functional outcome in all the patients was good. All patients were relieved of their primordial feminine tension and satisfied with the surgery. Their personality, lifestyle, and self-esteem improved remarkably following surgery.

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Defining giant mandibular ameloblastomas – is a separate clinical sub-entity warranted?

Aditya V Kanoi, Tibar Banerjee, Narayanamurthy Sundaramurthy, Arindam Sarkar, Pooja Kanoi, Sushovan Saha

Indian Journal of Plastic Surgery 2018 51(2):208-215

Context: The term giant mandibular ameloblastoma (GMAs) while being in popular usage in the medical literature remains largely equivocal. Although a few authors have in the past attempted to ascribe definite criteria to this entity, these are by and large arbitrary and without any benefit in decision-making or contributing to its management. Aims: The aim of this study is to propose a set of objective criteria for GMAs that can be clinically correlated and thereby aid in the management of this entity. Patients and Methods: Of a total of 16 patients with ameloblastoma of the mandible presenting at our institute from August 2012 to September 2016, 11 patients were identified as having GMAs as per the criteria proposed. Results: The defects in the mandible following segmental resection ranged from 7 to 11.5 cm in length (mean: 9.3 cm). No clinical or radiological evidence of tumour recurrence was found during a mean follow-up period of 10.7 months (range: 2–28 months). Conclusions: Defining GMA based on objective inclusion and exclusion criteria allows segregation of these lesions, thereby helping to remove ambiguity, simplify decision-making and facilitate communication among treating reconstructive surgeons. Inclusion criteria include: (i) The segmental bone defect following resection with a minimum 1 cm margin of healthy bone should exceed 6 cm (ii) The segmental bone defect should involve the central mandibular segment.

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Commentary on: Application of embryonic equivalents in male-to-female sex reassignment surgery

Richie Gupta

Indian Journal of Plastic Surgery 2018 51(2):167-169



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Primary free fibula reconstruction in life-threatening haemorrhage from high flow arteriovenous malformation of mandible

Parvathi Ravula, Srikanth Rangachari, Rammurti Susarla, Laxman Sambari, Srinivas Saraswathi Jammula

Indian Journal of Plastic Surgery 2018 51(2):222-230

Background: High flow arteriovenous malformation (AVM) of the mandible is rare, but it can present as a life-threatening emergency with severe intraoral bleeding for the first time. The gold standard of treatment for an AVM of the mandible is selective embolisation combined with resection and subsequent reconstructions. With the advent of advanced multidisciplinary techniques aimed at definitive therapy, surgical resection and primary reconstruction can provide an ideal anatomical and functional cure. There are no previous reports on primary resection and reconstruction for life-threatening haemorrhage from high flow AVM of the mandible. Aim: We discuss our approach aimed at definitive therapy in life-threatening intraoral bleeding from large high flow AVM of the mandible. Subjects and Methods: Four patients were managed for life-threatening intraoral bleeding during 2015–2017. Compression was applied over the bleeding point before the airway could be secured by endotracheal tube. Under general anaesthesia, the external carotid artery (ECA) was temporarily occluded using an umbilical tape loop ligature to control the bleeding. Emergency selective embolisation was done, followed by curative resection and primary mandible reconstruction using free fibula flap. Outcome assessed. Results: Temporary occlusion of the ECA successfully controlled the bleeding immediately and facilitated selective embolisation and definitive therapy. All the four cases were successfully reconstructed with a good outcome. There was no recurrence during the follow-up period. Conclusion: In life-threatening intraoral bleeding from large high flow AVM of the mandible, emergency selective embolisation followed by curative resection and primary reconstruction is safe in achieving an ideal cure.

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The role of plastic and reconstructive surgeon in trauma care: Perspectives from a Level 1 trauma centre in India

Maneesh Singhal, Ravikiran Naalla, Aniket Dave, Moumita De , Deepti Gupta, Shashank Chauhan

Indian Journal of Plastic Surgery 2018 51(2):170-176

Background: As the morbidity and mortality due to trauma are ever increasing, there is proportionally growing need of trauma care facilities across the country. In the context of expanding designated trauma care facilities, the role of plastic and reconstructive surgeon needs to be analysed and defined at least at a Level 1 trauma centre. Materials and Methods: We included the patients who were operated under the department of plastic, reconstructive & burns surgery at a Level 1 urban trauma centre between January 2016 and December 2017. We analysed the demographic data and categorised operative data according to anatomical areas and interacting specialties. Results: A total of 1539 procedures were performed under the division of plastic reconstructive and burn surgery. Amongst them, 81% were male, and 19% were female. Mean age was 27.3 years (range: 3–90 years). The anatomical locations treated were upper limb (49%), lower limb (35%), head and neck (8%) and trunk (8%). Interdepartmental cases were 600 and majority of them were in collaboration with orthopaedics (n = 298), general surgery (n = 163), neurosurgery (79) and maxillofacial surgery (60). Conclusion: There is a significant role of plastic surgeon at a Level 1 trauma centre in India. The plastic surgeon's interventions are limb saving and sometimes lifesaving, many at times morbidity of post-traumatic sequelae are either prevented or treated. Along with other core specialties involved in the management of trauma, plastic surgeons play an integral role in a Level 1 trauma centre. The policymakers should take note to augment the number of plastic surgeons at a Level 1 apex trauma centre on par with other specialties, as the workload is heavy and is steadily on an increasing trend.

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Borrowed feathers or Jugad

Ravin Thatte

Indian Journal of Plastic Surgery 2018 51(2):235-237



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Academic integrity and plagiarism: The new regulations in India

Dinesh Kadam

Indian Journal of Plastic Surgery 2018 51(2):109-110



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RoTMZK

Shaping the nasal tip: A new approach to transdomal suturing

Argyro Kypraiou, Petros V Vlastarakos, Stefanos Papailiadis

Indian Journal of Plastic Surgery 2018 51(2):247-248



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pw3V9I

Dr. Anil Chadha

Ayyappan Thangavel

Indian Journal of Plastic Surgery 2018 51(2):111-114



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An important superficial vein of the radial aspect of the forearm: An anatomical study

Madhubari Vathulya, Mohd Salahuddin Ansari

Indian Journal of Plastic Surgery 2018 51(2):231-234

Introduction: The superficial veins of upper limbs are seldom talked about. They are always avoided quoting them to be variable in anatomy. Other than the cephalic and basilic veins, no other superficial vein has caught the eyes of anatomists and other health professionals significantly. This article tries to explain the importance of a superficial vein that closely traces the radial vessels and explains its possible use in microvascular reconstruction. Materials and Methods: The forelimbs of 26 upper limbs of fresh frozen cadavers were dissected out. The anatomy of the superficial vein that follows the radial vessels was traced out from wrist to cubital fossa. Their relation to the deep venous system and cephalic veins was followed and documented. Results: All the 26 upper limbs showed the existence of the superficial vein that follows the radial vessels. The study also revealed the existence of venous perforators which are in turn the communication channels between the deep and superficial venous systems. Conclusion: The existence of the surface vein can logically hold an explanation for flap failure or success when one vein anastomosis is contemplated for radial forearm-free tissue transfers.

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Fixators to retractors: Use of k-wires and glove rings as self-retaining retractors

Narayanamurthy Sundaramurthy, Manimaran Ramachandran, Surya Rao Rao Venkata Mahipathy, Alagar Raja Durairaj, Praveen Ganesh Natarajan

Indian Journal of Plastic Surgery 2018 51(2):254-255



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PxCYlO

Birth palsy in congenital varicella syndrome: A lesson in anatomy

Ajeesh Sankaran, Praveen Bhardwaj, Hari Venkatramani, Shanmuganathan Raja Sabapathy

Indian Journal of Plastic Surgery 2018 51(2):238-242

While brachial plexus palsy sustained due to birth trauma is well known, congenital palsies are decidedly rare. We report such a case caused by congenital varicella syndrome, with associated congenital Horner's syndrome and heterochromia iridis. The surprising juxtaposition of a classic upper plexus palsy and a Horner's syndrome raises points of interest. Similar reports in literature are reviewed, and the genesis of a very characteristic group of findings is discussed.

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Encounter of plastic surgeons with pentazocine abuse: Lack of awareness or information overloaded

Neeti Neha, Veena Singh, Nandesh Kumar

Indian Journal of Plastic Surgery 2018 51(2):250-252



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Essentials of aesthetic surgery Jeffery J. Janis

Surajit Bhattacharya

Indian Journal of Plastic Surgery 2018 51(2):258-259



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PwQTIU

Application of embryonic equivalents in male-to-female sex reassignment surgery

Balakrishnan Margabandu Thalaivirithan, Maithreyi Sethu, Dinesh Karuvakkurichi Ramachandran, Mahadevan Kandasamy, Jaganmohan Janardhanam

Indian Journal of Plastic Surgery 2018 51(2):155-166

Introduction: The feeling of incongruence between phenotypic sex and psychological recognition of self-gender is termed gender dysphoria. Transsexualism is the most extreme form of this disorder. Aims and Objectives: The aims and objectives of the study are to evaluate the esthetic and functional outcome of embryonic equivalents-based male-to-female sex reassignment surgery in transwomen using the institutional scoring system. Materials and Methods: Thirty transwomen who had undergone male-to-female embryonic equivalents-based sex reassignment surgery (MFEEbSRS) from October 2012 to March 2016 were retrospectively studied. The outcome was evaluated by two independent plastic surgeons, based on interview with the individuals, visual assessment, and measurements. Surgical Technique: Clitoris was created from reduced glans on dorsal penile pedicle mounted on the crura of the conjoined corpora cavernosa. De-gloved unfurled proximal penile skin formed the introitus, hood for clitoris and labia minora. Neo-external urethral meatus was fashioned from the distal portion of the bulbar urethra. Distal de-gloved inverted penile tube flap was used for the creation of neovagina. Reduced scrotal flaps formed the labia majora. Observation and Results: The maximum length of neovagina in the study was 12 cm, and the average length was 9.8 cm. Based on our institutional scoring system for the assessment of esthetic and functional outcome, we got excellent results in all transwomen. Conclusion: The esthetic and functional outcome in all the patients was good. All patients were relieved of their primordial feminine tension and satisfied with the surgery. Their personality, lifestyle, and self-esteem improved remarkably following surgery.

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Defining giant mandibular ameloblastomas – is a separate clinical sub-entity warranted?

Aditya V Kanoi, Tibar Banerjee, Narayanamurthy Sundaramurthy, Arindam Sarkar, Pooja Kanoi, Sushovan Saha

Indian Journal of Plastic Surgery 2018 51(2):208-215

Context: The term giant mandibular ameloblastoma (GMAs) while being in popular usage in the medical literature remains largely equivocal. Although a few authors have in the past attempted to ascribe definite criteria to this entity, these are by and large arbitrary and without any benefit in decision-making or contributing to its management. Aims: The aim of this study is to propose a set of objective criteria for GMAs that can be clinically correlated and thereby aid in the management of this entity. Patients and Methods: Of a total of 16 patients with ameloblastoma of the mandible presenting at our institute from August 2012 to September 2016, 11 patients were identified as having GMAs as per the criteria proposed. Results: The defects in the mandible following segmental resection ranged from 7 to 11.5 cm in length (mean: 9.3 cm). No clinical or radiological evidence of tumour recurrence was found during a mean follow-up period of 10.7 months (range: 2–28 months). Conclusions: Defining GMA based on objective inclusion and exclusion criteria allows segregation of these lesions, thereby helping to remove ambiguity, simplify decision-making and facilitate communication among treating reconstructive surgeons. Inclusion criteria include: (i) The segmental bone defect following resection with a minimum 1 cm margin of healthy bone should exceed 6 cm (ii) The segmental bone defect should involve the central mandibular segment.

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Commentary on: Application of embryonic equivalents in male-to-female sex reassignment surgery

Richie Gupta

Indian Journal of Plastic Surgery 2018 51(2):167-169



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Primary free fibula reconstruction in life-threatening haemorrhage from high flow arteriovenous malformation of mandible

Parvathi Ravula, Srikanth Rangachari, Rammurti Susarla, Laxman Sambari, Srinivas Saraswathi Jammula

Indian Journal of Plastic Surgery 2018 51(2):222-230

Background: High flow arteriovenous malformation (AVM) of the mandible is rare, but it can present as a life-threatening emergency with severe intraoral bleeding for the first time. The gold standard of treatment for an AVM of the mandible is selective embolisation combined with resection and subsequent reconstructions. With the advent of advanced multidisciplinary techniques aimed at definitive therapy, surgical resection and primary reconstruction can provide an ideal anatomical and functional cure. There are no previous reports on primary resection and reconstruction for life-threatening haemorrhage from high flow AVM of the mandible. Aim: We discuss our approach aimed at definitive therapy in life-threatening intraoral bleeding from large high flow AVM of the mandible. Subjects and Methods: Four patients were managed for life-threatening intraoral bleeding during 2015–2017. Compression was applied over the bleeding point before the airway could be secured by endotracheal tube. Under general anaesthesia, the external carotid artery (ECA) was temporarily occluded using an umbilical tape loop ligature to control the bleeding. Emergency selective embolisation was done, followed by curative resection and primary mandible reconstruction using free fibula flap. Outcome assessed. Results: Temporary occlusion of the ECA successfully controlled the bleeding immediately and facilitated selective embolisation and definitive therapy. All the four cases were successfully reconstructed with a good outcome. There was no recurrence during the follow-up period. Conclusion: In life-threatening intraoral bleeding from large high flow AVM of the mandible, emergency selective embolisation followed by curative resection and primary reconstruction is safe in achieving an ideal cure.

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The role of plastic and reconstructive surgeon in trauma care: Perspectives from a Level 1 trauma centre in India

Maneesh Singhal, Ravikiran Naalla, Aniket Dave, Moumita De , Deepti Gupta, Shashank Chauhan

Indian Journal of Plastic Surgery 2018 51(2):170-176

Background: As the morbidity and mortality due to trauma are ever increasing, there is proportionally growing need of trauma care facilities across the country. In the context of expanding designated trauma care facilities, the role of plastic and reconstructive surgeon needs to be analysed and defined at least at a Level 1 trauma centre. Materials and Methods: We included the patients who were operated under the department of plastic, reconstructive & burns surgery at a Level 1 urban trauma centre between January 2016 and December 2017. We analysed the demographic data and categorised operative data according to anatomical areas and interacting specialties. Results: A total of 1539 procedures were performed under the division of plastic reconstructive and burn surgery. Amongst them, 81% were male, and 19% were female. Mean age was 27.3 years (range: 3–90 years). The anatomical locations treated were upper limb (49%), lower limb (35%), head and neck (8%) and trunk (8%). Interdepartmental cases were 600 and majority of them were in collaboration with orthopaedics (n = 298), general surgery (n = 163), neurosurgery (79) and maxillofacial surgery (60). Conclusion: There is a significant role of plastic surgeon at a Level 1 trauma centre in India. The plastic surgeon's interventions are limb saving and sometimes lifesaving, many at times morbidity of post-traumatic sequelae are either prevented or treated. Along with other core specialties involved in the management of trauma, plastic surgeons play an integral role in a Level 1 trauma centre. The policymakers should take note to augment the number of plastic surgeons at a Level 1 apex trauma centre on par with other specialties, as the workload is heavy and is steadily on an increasing trend.

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Borrowed feathers or Jugad

Ravin Thatte

Indian Journal of Plastic Surgery 2018 51(2):235-237



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PTEN and miR‐26b: Promising prognostic biomarkers in initiation and progression of Oral Squamous Cell Carcinoma

Journal of Oral Pathology &Medicine, Volume 0, Issue ja, -Not available-.


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PTEN and miR‐26b: Promising prognostic biomarkers in initiation and progression of Oral Squamous Cell Carcinoma

Journal of Oral Pathology &Medicine, Volume 0, Issue ja, -Not available-.


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Tips for Targeting Curriculum-Based Language and Literacy

As a speech-language pathologist, I'm fascinated by the effect of language on literacy. I'm constantly learning, sharing ideas, and collaborating with other professionals on strategies for improving students' phonemic awareness, morphology, syntax, comprehension, spelling or written expression.  I'm so interested in this topic, that a few years back, I initiated a Facebook group, "The Speech-Language Pathologist's Role in Language and Literacy." Below, I share strategies to target comprehension for expository text and vocabulary instruction. Two primary areas SLPs can target to improve comprehension for expository text include background knowledge and vocabulary (in the text as well as general academic vocabulary). To get a head start, I gather curriculum information...

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Where Will the 500,000 Teens With Autism Work When They ’ re Adults?

October is National Disability Employment Awareness Month, hosted by the U.S. Department of Labor. Although this has been a designated event—in various forms—since 1945, few companies actively recruit people with disabilities. A structured UPS on-the-job training program helps young adults with autism prepare for life and work.   Job Programs for People With Autism Show Promise   Website Connects Employers to Job-Seekers With Autism A recent article in the Houston Chronicle highlights this issue. The headline shares a statistic from advocacy group Autism Speaks, estimating that 500,000 teens with autism will age out of school programs over the next decade. The rate of autism occurrence also continues to climb, with the Centers for Disease Control and Prevention increasing the rate ...

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Tips for Targeting Curriculum-Based Language and Literacy

As a speech-language pathologist, I'm fascinated by the effect of language on literacy. I'm constantly learning, sharing ideas, and collaborating with other professionals on strategies for improving students' phonemic awareness, morphology, syntax, comprehension, spelling or written expression.  I'm so interested in this topic, that a few years back, I initiated a Facebook group, "The Speech-Language Pathologist's Role in Language and Literacy." Below, I share strategies to target comprehension for expository text and vocabulary instruction. Two primary areas SLPs can target to improve comprehension for expository text include background knowledge and vocabulary (in the text as well as general academic vocabulary). To get a head start, I gather curriculum information...

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Where Will the 500,000 Teens With Autism Work When They ’ re Adults?

October is National Disability Employment Awareness Month, hosted by the U.S. Department of Labor. Although this has been a designated event—in various forms—since 1945, few companies actively recruit people with disabilities. A structured UPS on-the-job training program helps young adults with autism prepare for life and work.   Job Programs for People With Autism Show Promise   Website Connects Employers to Job-Seekers With Autism A recent article in the Houston Chronicle highlights this issue. The headline shares a statistic from advocacy group Autism Speaks, estimating that 500,000 teens with autism will age out of school programs over the next decade. The rate of autism occurrence also continues to climb, with the Centers for Disease Control and Prevention increasing the rate ...

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New Research Initiative to Focus on Cerebrovascular Diseases

A multidisciplinary group of clinical and bench researchers has been formed at the University of Rochester Medical Center to study cerebrovascular disease. The Cerebrovascular and Neurocognitive Research Group (CNRG), which consists of faculty from Neurology, Neurosurgery, Electrical and Computer Engineering, Microbiology and Immunology, and Vascular Biology will leverage advanced brain imaging technologies to investigate a number of diseases, including stroke, cerebral small vessel disease, and vascular dementia. (Source: University of Rochester Medical Center Press Releases)

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FDA considers labeling sesame for food allergies

The U.S. Food and Drug Administration is studying whether to add sesame as among foods that must be clearly labeled as an allergen on food packages. (Source: Health News - UPI.com)

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Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA ’s new consideration of labeling for sesame allergies

Food allergies have touched the lives of most of us. Thousands of Americans experience life-threatening, food-related reactions each year, and an estimated 20 people die from them annually. In some cases, such reactions occur despite a careful reading of packaged food labels by conscientious consumers. To me, that 's unacceptable. The FDA is committed to advancing our efforts to help ensure that Americans have access to the information they need about common allergens in packaged foods. (Source: Food and Drug Administration)

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Flu vaccine uptake is down on last year, official figures show

20% fewer over-65s have received the vaccine this year as practices wait for vaccines to be delivered Related items fromOnMedica Rapid rise in flu consultations putting strain on GPs Adjuvanted trivalent flu vaccine best option for over-65s Good evidence for sublingual immunotherapy Sublingual immunotherapy effective in children with allergies BMJ report questions swine flu jab transparency (Source: OnMedica Latest News)

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New Research Initiative to Focus on Cerebrovascular Diseases

A multidisciplinary group of clinical and bench researchers has been formed at the University of Rochester Medical Center to study cerebrovascular disease. The Cerebrovascular and Neurocognitive Research Group (CNRG), which consists of faculty from Neurology, Neurosurgery, Electrical and Computer Engineering, Microbiology and Immunology, and Vascular Biology will leverage advanced brain imaging technologies to investigate a number of diseases, including stroke, cerebral small vessel disease, and vascular dementia. (Source: University of Rochester Medical Center Press Releases)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OXS4Sp

FDA considers labeling sesame for food allergies

The U.S. Food and Drug Administration is studying whether to add sesame as among foods that must be clearly labeled as an allergen on food packages. (Source: Health News - UPI.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2COTd7i

Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA ’s new consideration of labeling for sesame allergies

Food allergies have touched the lives of most of us. Thousands of Americans experience life-threatening, food-related reactions each year, and an estimated 20 people die from them annually. In some cases, such reactions occur despite a careful reading of packaged food labels by conscientious consumers. To me, that 's unacceptable. The FDA is committed to advancing our efforts to help ensure that Americans have access to the information they need about common allergens in packaged foods. (Source: Food and Drug Administration)

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Flu vaccine uptake is down on last year, official figures show

20% fewer over-65s have received the vaccine this year as practices wait for vaccines to be delivered Related items fromOnMedica Rapid rise in flu consultations putting strain on GPs Adjuvanted trivalent flu vaccine best option for over-65s Good evidence for sublingual immunotherapy Sublingual immunotherapy effective in children with allergies BMJ report questions swine flu jab transparency (Source: OnMedica Latest News)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CKPRCt

New Research Initiative to Focus on Cerebrovascular Diseases

A multidisciplinary group of clinical and bench researchers has been formed at the University of Rochester Medical Center to study cerebrovascular disease. The Cerebrovascular and Neurocognitive Research Group (CNRG), which consists of faculty from Neurology, Neurosurgery, Electrical and Computer Engineering, Microbiology and Immunology, and Vascular Biology will leverage advanced brain imaging technologies to investigate a number of diseases, including stroke, cerebral small vessel disease, and vascular dementia. (Source: University of Rochester Medical Center Press Releases)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OXS4Sp

FDA considers labeling sesame for food allergies

The U.S. Food and Drug Administration is studying whether to add sesame as among foods that must be clearly labeled as an allergen on food packages. (Source: Health News - UPI.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2COTd7i

Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA ’s new consideration of labeling for sesame allergies

Food allergies have touched the lives of most of us. Thousands of Americans experience life-threatening, food-related reactions each year, and an estimated 20 people die from them annually. In some cases, such reactions occur despite a careful reading of packaged food labels by conscientious consumers. To me, that 's unacceptable. The FDA is committed to advancing our efforts to help ensure that Americans have access to the information they need about common allergens in packaged foods. (Source: Food and Drug Administration)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OXPOuf

Flu vaccine uptake is down on last year, official figures show

20% fewer over-65s have received the vaccine this year as practices wait for vaccines to be delivered Related items fromOnMedica Rapid rise in flu consultations putting strain on GPs Adjuvanted trivalent flu vaccine best option for over-65s Good evidence for sublingual immunotherapy Sublingual immunotherapy effective in children with allergies BMJ report questions swine flu jab transparency (Source: OnMedica Latest News)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CKPRCt

New Research Initiative to Focus on Cerebrovascular Diseases

A multidisciplinary group of clinical and bench researchers has been formed at the University of Rochester Medical Center to study cerebrovascular disease. The Cerebrovascular and Neurocognitive Research Group (CNRG), which consists of faculty from Neurology, Neurosurgery, Electrical and Computer Engineering, Microbiology and Immunology, and Vascular Biology will leverage advanced brain imaging technologies to investigate a number of diseases, including stroke, cerebral small vessel disease, and vascular dementia. (Source: University of Rochester Medical Center Press Releases)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OXS4Sp

FDA considers labeling sesame for food allergies

The U.S. Food and Drug Administration is studying whether to add sesame as among foods that must be clearly labeled as an allergen on food packages. (Source: Health News - UPI.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2COTd7i

Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA ’s new consideration of labeling for sesame allergies

Food allergies have touched the lives of most of us. Thousands of Americans experience life-threatening, food-related reactions each year, and an estimated 20 people die from them annually. In some cases, such reactions occur despite a careful reading of packaged food labels by conscientious consumers. To me, that 's unacceptable. The FDA is committed to advancing our efforts to help ensure that Americans have access to the information they need about common allergens in packaged foods. (Source: Food and Drug Administration)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OXPOuf

Flu vaccine uptake is down on last year, official figures show

20% fewer over-65s have received the vaccine this year as practices wait for vaccines to be delivered Related items fromOnMedica Rapid rise in flu consultations putting strain on GPs Adjuvanted trivalent flu vaccine best option for over-65s Good evidence for sublingual immunotherapy Sublingual immunotherapy effective in children with allergies BMJ report questions swine flu jab transparency (Source: OnMedica Latest News)

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A Survey of Imaging Informatics Fellowships and Their Curricula: Current State Assessment

Abstract

In a 2016 survey of imaging informatics ("II") fellowship graduates, the surveyed fellowship graduates expressed the "opinion that II fellowships needed further formalization and standardization" Liao et al. (J Digit Imaging, 2016). This, coupled with the fact that the original published "standardized" curriculum is about 15 years out of date in our rapidly changing systems, suggests an opportunity for curriculum improvement. Before agreeing on improved structural and content suggestions for fellowships, we completed a current-state assessment of how each fellowship organizes its education and what requirements each have for fellowship completion. In this work, we aimed to collect existing information about imaging informatics fellowship curricula by contacting institutions across the country. A survey was completed by phone with the fellowship directors of existing imaging informatics fellowships across the country. Additionally, we collected existing documentation that outlines the curricula currently in use at institutions. We reviewed both the interview responses and documentation to assess overlapping trends and institutional differences in curriculum structure and content. All fellowships had suggested reading lists, didactic lectures, and a required project for each fellow. There were required practicum activities or teaching experience each in two fellowships, and one fellowship had a mandatory certification requirement for graduation. Curriculum topics in Technical Informatics or Business and Management were covered by a majority of institutions, while Quality and Safety and Research topics had inconsistent coverage across fellowships. Our plan is to reengage II fellowship directors to develop a core curriculum, which is part of the Society of Imaging Informatics in Medicine strategic plan.



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A Survey of Imaging Informatics Fellowships and Their Curricula: Current State Assessment

Abstract

In a 2016 survey of imaging informatics ("II") fellowship graduates, the surveyed fellowship graduates expressed the "opinion that II fellowships needed further formalization and standardization" Liao et al. (J Digit Imaging, 2016). This, coupled with the fact that the original published "standardized" curriculum is about 15 years out of date in our rapidly changing systems, suggests an opportunity for curriculum improvement. Before agreeing on improved structural and content suggestions for fellowships, we completed a current-state assessment of how each fellowship organizes its education and what requirements each have for fellowship completion. In this work, we aimed to collect existing information about imaging informatics fellowship curricula by contacting institutions across the country. A survey was completed by phone with the fellowship directors of existing imaging informatics fellowships across the country. Additionally, we collected existing documentation that outlines the curricula currently in use at institutions. We reviewed both the interview responses and documentation to assess overlapping trends and institutional differences in curriculum structure and content. All fellowships had suggested reading lists, didactic lectures, and a required project for each fellow. There were required practicum activities or teaching experience each in two fellowships, and one fellowship had a mandatory certification requirement for graduation. Curriculum topics in Technical Informatics or Business and Management were covered by a majority of institutions, while Quality and Safety and Research topics had inconsistent coverage across fellowships. Our plan is to reengage II fellowship directors to develop a core curriculum, which is part of the Society of Imaging Informatics in Medicine strategic plan.



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Philips board backs reappointment of CEO van Houten, CFO Bhattacharya | Personnel Moves – October 29, 2018

Royal Philips (NYSE:PHG) said today that its board of directors is backing the re-appointment of Frans van Houten as its president and CEO and Abhijit Bhattacharya as chief financial officer and board member. CEO van Houten has been at the head of Philips since 2011, while Bhattacharya joined the company in 2015, Amsterdam-based Philips said. During his time in the corner office, van Houten led the initial public offering for Philips Lighting in May 2016 and has increased R&D investments and led acquisitions including Volcano, Spectranetics, Wellcentive and VitalHealth. Board members will officially vote on a new CEO and CFO next May at the company's annual general meeting of shareholders. "The supervisory board is very pleased that Frans van Houten and Abhijit Bhattachary...

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Philips board backs reappointment of CEO van Houten, CFO Bhattacharya | Personnel Moves – October 29, 2018

Royal Philips (NYSE:PHG) said today that its board of directors is backing the re-appointment of Frans van Houten as its president and CEO and Abhijit Bhattacharya as chief financial officer and board member. CEO van Houten has been at the head of Philips since 2011, while Bhattacharya joined the company in 2015, Amsterdam-based Philips said. During his time in the corner office, van Houten led the initial public offering for Philips Lighting in May 2016 and has increased R&D investments and led acquisitions including Volcano, Spectranetics, Wellcentive and VitalHealth. Board members will officially vote on a new CEO and CFO next May at the company's annual general meeting of shareholders. "The supervisory board is very pleased that Frans van Houten and Abhijit Bhattachary...

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Delta radiomics for rectal cancer response prediction with hybrid 0.35 T magnetic resonance-guided radiotherapy (MRgRT): a hypothesis-generating study for an innovative personalized medicine approach

Abstract

The aim of this study was to evaluate the variation of radiomics features, defined as "delta radiomics", in patients undergoing neoadjuvant radiochemotherapy (RCT) for rectal cancer treated with hybrid magnetic resonance (MR)-guided radiotherapy (MRgRT). The delta radiomics features were then correlated with clinical complete response (cCR) outcome, to investigate their predictive power. A total of 16 patients were enrolled, and 5 patients (31%) showed cCR at restaging examinations. T2*/T1 MR images acquired with a hybrid 0.35 T MRgRT unit were considered for this analysis. An imaging acquisition protocol of 6 MR scans per patient was performed: the first MR was acquired at first simulation (t0) and the remaining ones at fractions 5, 10, 15, 20 and 25. Radiomics features were extracted from the gross tumour volume (GTV), and each feature was correlated with the corresponding delivered dose. The variations of each feature during treatment were quantified, and the ratio between the values calculated at different dose levels and the one extracted at t0 was calculated too. The Wilcoxon–Mann–Whitney test was performed to identify the features whose variation can be predictive of cCR, assessed with a MR acquired 6 weeks after RCT and digital examination. The most predictive feature ratios in cCR prediction were the L_least and glnu ones, calculated at the second week of treatment (22 Gy) with a p value = 0.001. Delta radiomics approach showed promising results and the quantitative analysis of images throughout MRgRT treatment can successfully predict cCR offering an innovative personalized medicine approach to rectal cancer treatment.



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Delta radiomics for rectal cancer response prediction with hybrid 0.35 T magnetic resonance-guided radiotherapy (MRgRT): a hypothesis-generating study for an innovative personalized medicine approach

Abstract

The aim of this study was to evaluate the variation of radiomics features, defined as "delta radiomics", in patients undergoing neoadjuvant radiochemotherapy (RCT) for rectal cancer treated with hybrid magnetic resonance (MR)-guided radiotherapy (MRgRT). The delta radiomics features were then correlated with clinical complete response (cCR) outcome, to investigate their predictive power. A total of 16 patients were enrolled, and 5 patients (31%) showed cCR at restaging examinations. T2*/T1 MR images acquired with a hybrid 0.35 T MRgRT unit were considered for this analysis. An imaging acquisition protocol of 6 MR scans per patient was performed: the first MR was acquired at first simulation (t0) and the remaining ones at fractions 5, 10, 15, 20 and 25. Radiomics features were extracted from the gross tumour volume (GTV), and each feature was correlated with the corresponding delivered dose. The variations of each feature during treatment were quantified, and the ratio between the values calculated at different dose levels and the one extracted at t0 was calculated too. The Wilcoxon–Mann–Whitney test was performed to identify the features whose variation can be predictive of cCR, assessed with a MR acquired 6 weeks after RCT and digital examination. The most predictive feature ratios in cCR prediction were the L_least and glnu ones, calculated at the second week of treatment (22 Gy) with a p value = 0.001. Delta radiomics approach showed promising results and the quantitative analysis of images throughout MRgRT treatment can successfully predict cCR offering an innovative personalized medicine approach to rectal cancer treatment.



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Philips board backs reappointment of CEO van Houten, CFO Bhattacharya | Personnel Moves – October 29, 2018

Royal Philips (NYSE:PHG) said today that its board of directors is backing the re-appointment of Frans van Houten as its president and CEO and Abhijit Bhattacharya as chief financial officer and board member. CEO van Houten has been at the head of Philips since 2011, while Bhattacharya joined the company in 2015, Amsterdam-based Philips said. During his time in the corner office, van Houten led the initial public offering for Philips Lighting in May 2016 and has increased R&D investments and led acquisitions including Volcano, Spectranetics, Wellcentive and VitalHealth. Board members will officially vote on a new CEO and CFO next May at the company's annual general meeting of shareholders. "The supervisory board is very pleased that Frans van Houten and Abhijit Bhattachary...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Js2kwc

Philips board backs reappointment of CEO van Houten, CFO Bhattacharya | Personnel Moves – October 29, 2018

Royal Philips (NYSE:PHG) said today that its board of directors is backing the re-appointment of Frans van Houten as its president and CEO and Abhijit Bhattacharya as chief financial officer and board member. CEO van Houten has been at the head of Philips since 2011, while Bhattacharya joined the company in 2015, Amsterdam-based Philips said. During his time in the corner office, van Houten led the initial public offering for Philips Lighting in May 2016 and has increased R&D investments and led acquisitions including Volcano, Spectranetics, Wellcentive and VitalHealth. Board members will officially vote on a new CEO and CFO next May at the company's annual general meeting of shareholders. "The supervisory board is very pleased that Frans van Houten and Abhijit Bhattachary...

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Autologous fat grafting in the treatment of velopharyngeal insufficiency: Clinical outcomes and treatment tolerability survey in a case series of 21 patients

Conclusions: The augmentation of the posterior pharyngeal wall in addition to speech therapy improved the Borel–Maisonny score and the intelligibility of this case series of patients affected by mild-to-moderate VPI. In these patients, evaluated in a multidisciplinary approach, this technique allowed us to avoid major surgical procedures that would modify the anatomy of the velopharyngeal port. However, prospective comparative studies or randomised controlled trials could be useful to compare fat grafting with velopharyngoplasty techniques, with the aim to clarify indications and to define a specific treatment protocol. (Source: Indian Journal of Plastic Surgery)

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Introduction: Regimes of language and the social, hierarchized organization of ideologies

Publication date: Available online 26 October 2018Source: Language & CommunicationAuthor(s): James CostaAbstractThis introduction seeks to problematize the notion of regimes of language with respect to how the term regimentation is used in the other social sciences, and with respect to language ideologies. It argues that regimentation, a term possibly more useful than regimes, strengthens the position already developed in semiotic anthropology that ideologies are not mere ideas but should also encompass social action, by focusing not only on 'the rules of the [linguistic] game' but also the strategies that guide social action. (Source: Language and Communication)

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Aspectual features and categorial shift: deverbal nominals in German and English

Publication date: Available online 27 October 2018Source: Language SciencesAuthor(s): Ulrike DemskeAbstractThe point of departure of this paper is the claim by Heyvaert, Maekelberghe & Buyle (this issue) that the suffix -ing has no aspectual meaning in English gerunds. Rather, the interpretation of nominal and verbal gerunds depends, so they argue, on situation or viewpoint aspect, a claim that contradicts the wide-spread view that the aspectual meaning of English gerunds is brought about by the nominalizing suffix. The present paper addresses the issue from a comparative perspective, focusing on German ung-nominals: while they share aspectual features with their English counterparts, empirical evidence from productivity, distribution, and argument linking shows (i) that the derivational s...

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Extreme classification

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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Talmy, Leonard: The targeting system of language

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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Standing up to the canoe: Competing cognitive biases in the encoding of stative spatial relations in a language with a single spatial preposition

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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Acknowledgment of Reviewers 2016 and 2017

(Source: Dysphagia)

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Explaining Reading Comprehension in Children With Developmental Language Disorder: The Importance of Elaborative Inferencing

Conclusions These results indicate that interventions targeting the reading comprehension of children with DLD should focus on elaborative inferencing skill. There are also clinical implications as the development of new standardized assessments differentiating between inference types is called for. (Source: Journal of Speech, Language, and Hearing Research)

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Perceptual Organization of Interrupted Speech and Text

Conclusion The observed rate-specific variation in the perception of speech and text may potentially affect the degree to which recognition accuracy in one modality is predictive of the other. (Source: Journal of Speech, Language, and Hearing Research)

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Chiari Type I Malformation Associated With Verbal Fluency Impairment

Conclusions From the results of this study, it can be concluded that people suffering from CM exhibit less verbal fluency than healthy control individuals and that this difference is not caused by depression or anxiety. (Source: Journal of Speech, Language, and Hearing Research)

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Dynamic Assessment of Narratives Among Navajo Preschoolers

Conclusion The PEARL is a promising assessment for accurately differentiating Navajo preschool children with LI from those with TD language, particularly with a revised pretest cutoff score. (Source: Journal of Speech, Language, and Hearing Research)

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Bilingual Speech Sound Development During the Preschool Years: The Role of Language Proficiency and Cross-Linguistic Relatedness

Conclusions This study is the first to document developmental changes in the speech patterns of Spanish –English bilingual preschool children over 1 year. Accuracy rates improved significantly in both languages, suggesting that enhanced exposure to the majority language at school may not impede phonological development in the home language. Bootstrapping effects were particularly pronounced on cross -linguistically shared sounds, which suggests that the same underlying skills are utilized in both languages, whereas language-specific singleton consonants and consonant clusters did not appear to benefit from exposure to the other language. The results also suggest an intricate link between phonol ogical skills and morphosyntactic performance at the early stages of development, but a more c...

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Managing and supporting quality-of-life issues in dysphagia: A survey of clinical practice patterns and perspectives in the UK, Ireland and South Africa.

CONCLUSIONS & IMPLICATIONS: SLTs believe they have an important role to play in supporting QOL issues in dysphagia. However, it is reported that the area is currently under-developed, under-resourced and under-supported. Increased awareness raising of the role of SLT, alongside the development of best-practice guidelines and disease-specific QOL assessment tools, will enhance the quality of care that can be offered in this area. PMID: 30362200 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)

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Examining Factors Influencing the Viability of Automatic Acoustic Analysis of Child Speech

Conclusions Alignment accuracy of child speech can be improved by using more specific training and transcription. However, poor alignment accuracy was not found to impede acoustic analysis of /s/ produced by even very young children. Thus, forced alignment presents a useful tool for the analysis of child speech.Supplemental Materialhttps://doi.org/10.23641/asha.7070105 (Source: Journal of Speech, Language, and Hearing Research)

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Changes in English Past Tense Use by Bilingual School-Age Children With and Without Developmental Language Disorder

Discussion Contrary to an earlier report (Jacobson& Schwartz, 2005), the relative greater difficulty with regular and novel verbs was replaced by greater difficulty for irregular past tense, a pattern consistent with monolingual impairment. Age was a contributing factor, particularly for younger children with DLD who produced more stem + ing errors in the novel verb condition. For all children, and particularly for those with DLD, an extended period for irregular past tense learning was evident. The results support a usage-based theory of language acquisition and impairment. (Source: Journal of Speech, Language, and Hearing Research)

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Characteristics of Speech Rate in Children With Cerebral Palsy: A Longitudinal Study

Conclusions There were no significant age-related differences in speech rate in children with CP regardless of group membership. Sentence length differentially impacted speech rate and its characteristics in both groups of children with CP. This may be due to cognitive –linguistic and/or speech motor control factors. (Source: Journal of Speech, Language, and Hearing Research)

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Development of Phonological, Lexical, and Syntactic Abilities in Children With Cochlear Implants Across the Elementary Grades

Conclusions Congenital hearing loss puts children at continued risk of language deficits, especially for phonologically based skills. Two interventions that appear to ameliorate that risk are providing a period of bimodal stimulation and strong literacy instruction. (Source: Journal of Speech, Language, and Hearing Research)

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