Penn researchers land $10.7M grant to study CAR-T cell therapy in solid tumors

The University of Pennsylvania's Abramson Cancer Center had received a $10.7 million grant from the National Cancer Institute to study CAR-T cells in solid tumors The five-year grant from the NCI's will support new experimental approaches in lung cancer and mesothelioma being conducted by Penn researchers at its translational center of excellence for lung cancer immunology "Although CAR-T cells have been revolutionized the treatment of leukemia and bone marrow cancers, we have not yet had the… (Source: bizjournals.com Health Care:Biotechnology headlines)

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A comprehensive institutional overview of intrathecal nusinersen injections for spinal muscular atrophy

Abstract

Background

Spinal muscular atrophy (SMA) is an autosomal-recessive neuromuscular disorder resulting in progressive muscle weakness. In December 2016, the U.S. Food and Drug Administration approved the first treatment for SMA, a drug named nusinersen (Spinraza) that is administered intrathecally. However many children with SMA have neuromuscular scoliosis or spinal instrumentation resulting in challenging intrathecal access. Therefore alternative routes must be considered in these complex patients.

Objective

To investigate routes of drug access, we reviewed our institutional experience of administering intrathecal nusinersen in all children with spinal muscular atrophy regardless of spinal anatomy or instrumentation.

Materials and methods

We reviewed children with SMA who were referred for intrathecal nusinersen injections from March to December 2017 at our institution. In select children with spinal hardware, spinal imaging was requested to facilitate pre-procedure planning. Standard equipment for intrathecal injections was utilized. All children were followed up by their referring neurologist.

Results

A total of 104 intrathecal nusinersen injections were performed in 26 children with 100% technical success. Sixty procedures were performed without pre-procedural imaging and via standard interspinous technique. The remaining 44 procedures were performed in 11 complex (i.e. neuromuscular scoliosis or spinal instrumentation) patients requiring pre-procedural imaging for planning purposes. Nineteen of the 44 complex procedures were performed via standard interspinous technique from L2 to S1. Twenty-two of the 44 complex procedures were performed using a neural-foraminal approach from L3 to L5. Three of the 44 complex procedures were performed via cervical puncture technique. There were no immediate or long-term complications but there was one child with short-term complications of meningismus and back pain at the injection site.

Conclusion

Although we achieved 100% technical success in intrathecal nusinersen administration, our practices evolved during the course of this study. As a result of our early experience we developed an algorithm to assist in promoting safe and effective nusinersen administration in children with spinal muscular atrophy regardless of SMA type, abnormal spinal anatomy and complex spinal instrumentation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ann4Ci

Meconium peritonitis: the role of postnatal radiographic and sonographic findings in predicting the need for surgery

Abstract

Background

The role of imaging in meconium peritonitis is not limited to establishing a diagnosis; rather, it might also be helpful in determining which neonates require surgery. However, few data in the literature correlate the postnatal radiographic and sonographic findings with the need for surgery.

Objective

To compare the role of postnatal radiographic and sonographic findings in predicting the need for surgery in neonates with meconium peritonitis.

Materials and methods

We conducted a retrospective analysis of clinical, imaging and surgical findings in all neonates with meconium peritonitis in the period 1999–2014. We divided the children into operative or non-operative groups and then correlated each group with the presence or absence of the following findings on both the radiographs and sonograms: peritoneal calcification, meconium pseudocyst, intestinal obstruction, volvulus, ascites and pneumoperitoneum.

Results

Thirty-seven neonates (22 males, 15 females) had meconium peritonitis in this period, of whom 23 (62%) required surgery and 14 (38%) were successfully treated non-surgically. None had an antenatal infection and three had cystic fibrosis (8%). Bowel obstruction identified on radiography (12/23, P=0.01) and sonography (9/23, P=0.04) and ascites identified with sonography (7/23, P=0.01) were associated with the need for surgical intervention. The presence of pneumoperitoneum and volvulus were also associated with surgical intervention. There was no significant statistical difference in the number of neonates with diffuse peritoneal calcification who were treated operatively or non-operatively. Four (33%) of the 12 neonates with meconium pseudocysts were successfully treated non-operatively.

Conclusion

Imaging findings that predicted the need for surgery were intestinal obstruction, ascites, volvulus and pneumoperitoneum. Neonates with meconium pseudocysts did not require surgery if they were not associated with the described findings. The findings in our patients also indicate that those with diffuse peritoneal calcification as an isolated finding can be successfully treated non-operatively.

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Hermes

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CyIUUY

Significance of pleural effusion at diagnosis in pediatric Hodgkin lymphoma: a report from Children’s Oncology Group protocol AHOD0031

Abstract

Background

Pleural effusion at presentation in Hodgkin lymphoma has been associated with inferior outcome but has not been systematically evaluated.

Objective

To determine whether pleural effusion at presentation in children with Hodgkin lymphoma is a primary indicator of poor prognosis or secondary to associated factors.

Materials and methods

Children's Oncology Group (COG) AHOD0031, a randomized, response-based, centrally reviewed protocol, enrolled 1,712 eligible patients <22 years of age with initial presentation of intermediate risk, biopsy-proven Hodgkin lymphoma; 1,423 had available imaging for retrospective review. We coded effusions as fluid-only or with associated pleural nodule or adjacent lung or bone involvement and correlated this with disease stage, tumor response, large mediastinal adenopathy, and mass effect on the superior vena cava (SVC) and left innominate vein. We recorded change in size and character of effusions post-chemotherapy.

Results

Pleural effusions were present in 217, with 204 having fluid-only and 13 having associated solid components. Patients with effusions were more likely to have large mediastinal adenopathy (P<0.0001), be slow early responders (P<0.0001) and have higher relapse rate (P<0.0001). Vascular compression was not significantly correlated with pleural effusion. Of 121 patients with adequate [F-18]2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/CT imaging, no FDG PET avidity was seen in any pleural effusion but was present in solid components. The side of the pleural effusion in those with moderate or large effusions was highly associated with the side of large mediastinal adenopathy (P<0.0001). Statistical analysis indicates that pleural effusion is an independent risk factor for poorer response and relapse.

Conclusion

Pleural effusion in Hodgkin lymphoma is an important independent poor prognostic indicator for response and relapse.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2And6ka

Pediatric Radiology Continuing Medical Education Activity

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cx9MEM

Allergic-like contrast media reaction management in children

Abstract

The use of contrast materials as part of imaging examinations is common in children of all ages, as these compounds increase image contrast, lesion detection and lesion characterization. Though modern iodinated, gadolinium-based and ultrasound microbubble contrast materials generally are quite safe, acute physiological and allergic-like reactions are possible. The majority of acute contrast reactions in children are mild and self-limited; however, life-threatening reactions can occur. It is our obligation as radiologists to recognize and manage these adverse reactions. The objective of this article is to review the frequency, manifestations and appropriate treatment of acute contrast reactions in the pediatric population.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cx9Xjq

Assessment of normal jejunum with diffusion-weighted imaging on MRE in children

Abstract

Background

Diffusion restriction has been utilized as a marker for bowel inflammation on magnetic resonance enterography (MRE). However, diffusion restriction has been seen in otherwise normal appearing small bowel in patients without active inflammation, with little published data on this subject.

Objective

Assess diffusion restriction in normal loops of jejunum and to determine if there is a correlation to luminal distention, age, magnet field strength, slice thickness, and bowel segment location.

Materials and methods

A retrospective analysis of subjects with a normal MRE and clinical work-up was performed. The abdomen was divided into four quadrants. If available, two loops of jejunum were randomly chosen in each quadrant. Two radiologists evaluated the loops of jejunum for distension, wall thickness, enhancement and diffusion restriction. Disagreement was resolved by consensus. Presence of diffusion restriction was correlated with luminal distension, age, magnet field strength, slice thickness and abdominal quadrant.

Results

One hundred ninety-seven loops of jejunum were evaluated in 39 subjects. Fifteen subjects (38.5%) had jejunal loops with diffusion restriction for a total of 28 loops. There was no correlation between diffusion restriction and luminal distension, age, magnet field strength or quadrant location (P>0.05, Pearson chi-squared test or Student's t-tests). Of the 15 subjects with a loop demonstrating diffusion restriction, additional loops with diffusion restriction were found in 40%. There was a very weak trend observed for greater slice thickness in patients with jejunal diffusion restriction (Student's t-test, P=0.10).

Conclusion

Jejunal diffusion restriction is a common finding in children with no clinical evidence of bowel pathology, irrespective of patient age, luminal distension, location of bowel loop and magnetic field strength. Further studies may be valuable in assessing the impact of slice thickness on subjective diffusion restriction in the jejunum.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ann45g

A pediatric radiologist in Rwanda

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cx9T3a

Imaging findings of iatrogenic pharyngeal and esophageal injuries in neonates

Abstract

Iatrogenic injuries to the upper gastrointestinal tract in neonates are rare but may lead to significant morbidity and mortality if undiagnosed. The clinical presentation of such injuries is usually nonspecific and symptoms may be overlooked, particularly in sick preterm neonates. Therefore, it is important to recognize the findings on plain chest radiographs obtained regularly in neonatal intensive care units (NICUs) on intubated patients. The purpose of this pictorial essay is to describe the imaging findings of various iatrogenic injuries to the pharynx and esophagus in the neonatal period in a cohort of seven cases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AnfdVu

Half-dose versus full-dose macrocyclic gadolinium at 3-T magnetic resonance imaging in paediatric bone and soft-tissue disease

Abstract

Background

Given the recent concerns about gadolinium-based contrast agent safety, dose reduction strategies are being investigated.

Objective

To compare half-dose and standard full-dose gadoterate meglumine at 3-tesla (T) MRI in paediatric bone and soft-tissue diseases.

Materials and methods

We prospectively enrolled 45 children (age range 2.7 months to 17.5 years, median age 8.7 years, 49 total anatomical segments) with bone and soft-tissue diseases (neoplastic, inflammatory/infectious, ischaemic and vascular) imaged at 3-T MRI. Two consecutive half-doses of gadoterate meglumine (0.05 mmol/kg body weight) were administered. Two sets of post-contrast T1-weighted images were obtained, one after the first half dose and the other after the second half dose. For qualitative analysis, three radiologists, masked to the gadolinium dose, compared the diagnostic quality of the images. For quantitative analysis, we compared signal-to-noise ratio and contrast-to-noise ratio at half and full doses.

Results

Signal-to-noise ratio and contrast-to-noise ratio did not vary significantly between the two groups. Qualitative analysis yielded excellent image quality in both post-contrast image datasets (Cohen κ=0.8).

Conclusion

In paediatric bone and soft-tissue 3-T MRI, it is feasible to halve the standard dose of gadoterate meglumine without losing image quality.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CyU1gr

Penn researchers land $10.7M grant to study CAR-T cell therapy in solid tumors

The University of Pennsylvania's Abramson Cancer Center had received a $10.7 million grant from the National Cancer Institute to study CAR-T cells in solid tumors The five-year grant from the NCI's will support new experimental approaches in lung cancer and mesothelioma being conducted by Penn researchers at its translational center of excellence for lung cancer immunology "Although CAR-T cells have been revolutionized the treatment of leukemia and bone marrow cancers, we have not yet had the… (Source: bizjournals.com Health Care:Biotechnology headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2S6ylxA

A comprehensive institutional overview of intrathecal nusinersen injections for spinal muscular atrophy

Abstract

Background

Spinal muscular atrophy (SMA) is an autosomal-recessive neuromuscular disorder resulting in progressive muscle weakness. In December 2016, the U.S. Food and Drug Administration approved the first treatment for SMA, a drug named nusinersen (Spinraza) that is administered intrathecally. However many children with SMA have neuromuscular scoliosis or spinal instrumentation resulting in challenging intrathecal access. Therefore alternative routes must be considered in these complex patients.

Objective

To investigate routes of drug access, we reviewed our institutional experience of administering intrathecal nusinersen in all children with spinal muscular atrophy regardless of spinal anatomy or instrumentation.

Materials and methods

We reviewed children with SMA who were referred for intrathecal nusinersen injections from March to December 2017 at our institution. In select children with spinal hardware, spinal imaging was requested to facilitate pre-procedure planning. Standard equipment for intrathecal injections was utilized. All children were followed up by their referring neurologist.

Results

A total of 104 intrathecal nusinersen injections were performed in 26 children with 100% technical success. Sixty procedures were performed without pre-procedural imaging and via standard interspinous technique. The remaining 44 procedures were performed in 11 complex (i.e. neuromuscular scoliosis or spinal instrumentation) patients requiring pre-procedural imaging for planning purposes. Nineteen of the 44 complex procedures were performed via standard interspinous technique from L2 to S1. Twenty-two of the 44 complex procedures were performed using a neural-foraminal approach from L3 to L5. Three of the 44 complex procedures were performed via cervical puncture technique. There were no immediate or long-term complications but there was one child with short-term complications of meningismus and back pain at the injection site.

Conclusion

Although we achieved 100% technical success in intrathecal nusinersen administration, our practices evolved during the course of this study. As a result of our early experience we developed an algorithm to assist in promoting safe and effective nusinersen administration in children with spinal muscular atrophy regardless of SMA type, abnormal spinal anatomy and complex spinal instrumentation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ann4Ci

Ultrasound diagnosis of tracheal cartilaginous sleeve in a patient with Pfeiffer syndrome

Abstract

There is an association between tracheal cartilaginous sleeve and syndromic craniosynostosis. We present a case of tracheal cartilaginous sleeve diagnosed by ultrasound (US) in a patient with Pfeiffer syndrome. The patient developed respiratory failure and was suspected at bronchoscopy to have tracheal cartilaginous sleeve. US performed before tracheostomy placement demonstrated continuous hypoechoic cartilage along the anterior surface of the trachea, confirming the diagnosis. Our report shows that US can make a definitive diagnosis of tracheal cartilaginous sleeve and raises the possibility of using US to screen for the condition in patients with syndromic craniosynostosis without the need for anesthesia or ionizing radiation.

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Hermes

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CyIUUY

Significance of pleural effusion at diagnosis in pediatric Hodgkin lymphoma: a report from Children’s Oncology Group protocol AHOD0031

Abstract

Background

Pleural effusion at presentation in Hodgkin lymphoma has been associated with inferior outcome but has not been systematically evaluated.

Objective

To determine whether pleural effusion at presentation in children with Hodgkin lymphoma is a primary indicator of poor prognosis or secondary to associated factors.

Materials and methods

Children's Oncology Group (COG) AHOD0031, a randomized, response-based, centrally reviewed protocol, enrolled 1,712 eligible patients <22 years of age with initial presentation of intermediate risk, biopsy-proven Hodgkin lymphoma; 1,423 had available imaging for retrospective review. We coded effusions as fluid-only or with associated pleural nodule or adjacent lung or bone involvement and correlated this with disease stage, tumor response, large mediastinal adenopathy, and mass effect on the superior vena cava (SVC) and left innominate vein. We recorded change in size and character of effusions post-chemotherapy.

Results

Pleural effusions were present in 217, with 204 having fluid-only and 13 having associated solid components. Patients with effusions were more likely to have large mediastinal adenopathy (P<0.0001), be slow early responders (P<0.0001) and have higher relapse rate (P<0.0001). Vascular compression was not significantly correlated with pleural effusion. Of 121 patients with adequate [F-18]2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/CT imaging, no FDG PET avidity was seen in any pleural effusion but was present in solid components. The side of the pleural effusion in those with moderate or large effusions was highly associated with the side of large mediastinal adenopathy (P<0.0001). Statistical analysis indicates that pleural effusion is an independent risk factor for poorer response and relapse.

Conclusion

Pleural effusion in Hodgkin lymphoma is an important independent poor prognostic indicator for response and relapse.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2And6ka

Pediatric Radiology Continuing Medical Education Activity

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cx9MEM

Barry Davis Fletcher, MDCM (1935–2018)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Anem6X

Allergic-like contrast media reaction management in children

Abstract

The use of contrast materials as part of imaging examinations is common in children of all ages, as these compounds increase image contrast, lesion detection and lesion characterization. Though modern iodinated, gadolinium-based and ultrasound microbubble contrast materials generally are quite safe, acute physiological and allergic-like reactions are possible. The majority of acute contrast reactions in children are mild and self-limited; however, life-threatening reactions can occur. It is our obligation as radiologists to recognize and manage these adverse reactions. The objective of this article is to review the frequency, manifestations and appropriate treatment of acute contrast reactions in the pediatric population.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cx9Xjq

Assessment of normal jejunum with diffusion-weighted imaging on MRE in children

Abstract

Background

Diffusion restriction has been utilized as a marker for bowel inflammation on magnetic resonance enterography (MRE). However, diffusion restriction has been seen in otherwise normal appearing small bowel in patients without active inflammation, with little published data on this subject.

Objective

Assess diffusion restriction in normal loops of jejunum and to determine if there is a correlation to luminal distention, age, magnet field strength, slice thickness, and bowel segment location.

Materials and methods

A retrospective analysis of subjects with a normal MRE and clinical work-up was performed. The abdomen was divided into four quadrants. If available, two loops of jejunum were randomly chosen in each quadrant. Two radiologists evaluated the loops of jejunum for distension, wall thickness, enhancement and diffusion restriction. Disagreement was resolved by consensus. Presence of diffusion restriction was correlated with luminal distension, age, magnet field strength, slice thickness and abdominal quadrant.

Results

One hundred ninety-seven loops of jejunum were evaluated in 39 subjects. Fifteen subjects (38.5%) had jejunal loops with diffusion restriction for a total of 28 loops. There was no correlation between diffusion restriction and luminal distension, age, magnet field strength or quadrant location (P>0.05, Pearson chi-squared test or Student's t-tests). Of the 15 subjects with a loop demonstrating diffusion restriction, additional loops with diffusion restriction were found in 40%. There was a very weak trend observed for greater slice thickness in patients with jejunal diffusion restriction (Student's t-test, P=0.10).

Conclusion

Jejunal diffusion restriction is a common finding in children with no clinical evidence of bowel pathology, irrespective of patient age, luminal distension, location of bowel loop and magnetic field strength. Further studies may be valuable in assessing the impact of slice thickness on subjective diffusion restriction in the jejunum.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ann45g

A pediatric radiologist in Rwanda

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cx9T3a

Imaging findings of iatrogenic pharyngeal and esophageal injuries in neonates

Abstract

Iatrogenic injuries to the upper gastrointestinal tract in neonates are rare but may lead to significant morbidity and mortality if undiagnosed. The clinical presentation of such injuries is usually nonspecific and symptoms may be overlooked, particularly in sick preterm neonates. Therefore, it is important to recognize the findings on plain chest radiographs obtained regularly in neonatal intensive care units (NICUs) on intubated patients. The purpose of this pictorial essay is to describe the imaging findings of various iatrogenic injuries to the pharynx and esophagus in the neonatal period in a cohort of seven cases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AnfdVu

Half-dose versus full-dose macrocyclic gadolinium at 3-T magnetic resonance imaging in paediatric bone and soft-tissue disease

Abstract

Background

Given the recent concerns about gadolinium-based contrast agent safety, dose reduction strategies are being investigated.

Objective

To compare half-dose and standard full-dose gadoterate meglumine at 3-tesla (T) MRI in paediatric bone and soft-tissue diseases.

Materials and methods

We prospectively enrolled 45 children (age range 2.7 months to 17.5 years, median age 8.7 years, 49 total anatomical segments) with bone and soft-tissue diseases (neoplastic, inflammatory/infectious, ischaemic and vascular) imaged at 3-T MRI. Two consecutive half-doses of gadoterate meglumine (0.05 mmol/kg body weight) were administered. Two sets of post-contrast T1-weighted images were obtained, one after the first half dose and the other after the second half dose. For qualitative analysis, three radiologists, masked to the gadolinium dose, compared the diagnostic quality of the images. For quantitative analysis, we compared signal-to-noise ratio and contrast-to-noise ratio at half and full doses.

Results

Signal-to-noise ratio and contrast-to-noise ratio did not vary significantly between the two groups. Qualitative analysis yielded excellent image quality in both post-contrast image datasets (Cohen κ=0.8).

Conclusion

In paediatric bone and soft-tissue 3-T MRI, it is feasible to halve the standard dose of gadoterate meglumine without losing image quality.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CyU1gr

Penn researchers land $10.7M grant to study CAR-T cell therapy in solid tumors

The University of Pennsylvania's Abramson Cancer Center had received a $10.7 million grant from the National Cancer Institute to study CAR-T cells in solid tumors The five-year grant from the NCI's will support new experimental approaches in lung cancer and mesothelioma being conducted by Penn researchers at its translational center of excellence for lung cancer immunology "Although CAR-T cells have been revolutionized the treatment of leukemia and bone marrow cancers, we have not yet had the… (Source: bizjournals.com Health Care:Biotechnology headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2S6ylxA

Penn researchers land $10.7M grant to study CAR-T cell therapy in solid tumors

The University of Pennsylvania's Abramson Cancer Center had received a $10.7 million grant from the National Cancer Institute to study CAR-T cells in solid tumors The five-year grant from the NCI's will support new experimental approaches in lung cancer and mesothelioma being conducted by Penn researchers at its translational center of excellence for lung cancer immunology "Although CAR-T cells have been revolutionized the treatment of leukemia and bone marrow cancers, we have not yet had the… (Source: bizjournals.com Health Care:Biotechnology headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2S6ylxA

Spotlight on Special Interest Group 12, Augmentative and Alternative Communication

SIG 12 is dedicated to improving the quality and availability of AAC services to consumers throughout the life span. Read on for why affiliate Kathy Beatty finds this SIG so professionally rewarding. When did you join your SIG—and what made you want to join? I have been a proud member of SIG 12 since 2010. I was presenting at the ASHA Schools Conference and spoke with a SIG 12 Coordinating Committee member about the benefits and support that I would receive by joining SIG 12. It was definitely a wise choice. How has your involvement with the SIG helped you in your career? Oh my goodness, in so many ways! The world of augmentative and alternative communication (AAC) changes at an incredible rate. It is wonderful to know that I have a place to find solid AAC clinical information. I part...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q4OYgf

Spotlight on Special Interest Group 12, Augmentative and Alternative Communication

SIG 12 is dedicated to improving the quality and availability of AAC services to consumers throughout the life span. Read on for why affiliate Kathy Beatty finds this SIG so professionally rewarding. When did you join your SIG—and what made you want to join? I have been a proud member of SIG 12 since 2010. I was presenting at the ASHA Schools Conference and spoke with a SIG 12 Coordinating Committee member about the benefits and support that I would receive by joining SIG 12. It was definitely a wise choice. How has your involvement with the SIG helped you in your career? Oh my goodness, in so many ways! The world of augmentative and alternative communication (AAC) changes at an incredible rate. It is wonderful to know that I have a place to find solid AAC clinical information. I part...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q4OYgf

Spotlight on Special Interest Group 12, Augmentative and Alternative Communication

SIG 12 is dedicated to improving the quality and availability of AAC services to consumers throughout the life span. Read on for why affiliate Kathy Beatty finds this SIG so professionally rewarding. When did you join your SIG—and what made you want to join? I have been a proud member of SIG 12 since 2010. I was presenting at the ASHA Schools Conference and spoke with a SIG 12 Coordinating Committee member about the benefits and support that I would receive by joining SIG 12. It was definitely a wise choice. How has your involvement with the SIG helped you in your career? Oh my goodness, in so many ways! The world of augmentative and alternative communication (AAC) changes at an incredible rate. It is wonderful to know that I have a place to find solid AAC clinical information. I part...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q4OYgf

Spotlight on Special Interest Group 12, Augmentative and Alternative Communication

SIG 12 is dedicated to improving the quality and availability of AAC services to consumers throughout the life span. Read on for why affiliate Kathy Beatty finds this SIG so professionally rewarding. When did you join your SIG—and what made you want to join? I have been a proud member of SIG 12 since 2010. I was presenting at the ASHA Schools Conference and spoke with a SIG 12 Coordinating Committee member about the benefits and support that I would receive by joining SIG 12. It was definitely a wise choice. How has your involvement with the SIG helped you in your career? Oh my goodness, in so many ways! The world of augmentative and alternative communication (AAC) changes at an incredible rate. It is wonderful to know that I have a place to find solid AAC clinical information. I part...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q4OYgf

Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

Recombinant adeno-associated virus (AAV) vectors have been broadly adopted as a gene delivery tool in clinical trials, owing to their high efficiency of transduction of several host tissues and their low immunogenicity. However, a considerable proportion of the population is naturally exposed to the WT virus from which AAV vectors are derived, which leads to the acquisition of immunological memory that can directly determine the outcome of gene transfer. Here, we show that prior exposure to AAV drives distinct capsid immunity profiles in healthy subjects. In peripheral blood mononuclear cells (PBMCs) isolated from AAV-seropositive donors, recombinant AAV triggered TNF-α secretion in memory CD8+ T cells, B cell differentiation into antibody-secreting cells, and anti-capsid antibody product...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3Rkpy

Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

Recombinant adeno-associated virus (AAV) vectors have been broadly adopted as a gene delivery tool in clinical trials, owing to their high efficiency of transduction of several host tissues and their low immunogenicity. However, a considerable proportion of the population is naturally exposed to the WT virus from which AAV vectors are derived, which leads to the acquisition of immunological memory that can directly determine the outcome of gene transfer. Here, we show that prior exposure to AAV drives distinct capsid immunity profiles in healthy subjects. In peripheral blood mononuclear cells (PBMCs) isolated from AAV-seropositive donors, recombinant AAV triggered TNF-α secretion in memory CD8+ T cells, B cell differentiation into antibody-secreting cells, and anti-capsid antibody product...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Mr John Jago 05 June 1940 –07 September 2018

Mr John Jago, formerly consultant maxillofacial surgeon at Dumfries and Galloway Hospitals, died peacefully at a hospital in southwest France on 7 September 2018, following a short illness. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NYogPZ

Multicentre approach to epidemiological aspects of craniosynostosis in Germany

We know of no current published data on the prevalence of craniosynostosis in Germany, so our objective in this study was to contribute to the limited knowledge of its epidemiology by assessing time trends, the frequency of prenatal diagnosis, and the timing of diagnosis and treatment. Data were collected in Saxony-Anhalt during the period 2000 –17, and we designed a retrospective multicentre cohort study. The prevalence was 4.8 cases of craniosynostosis/10 000 births, and did not increase during that time. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OHLvDn

Modification of Lackmann ’s classification of facial bite wounds: an aid to assessment and recording

We recently treated a 2-year-old toddler who had sustained serious right-sided facial injuries, including avulsion of the lower eyelid from its medial attachments, when he was attacked by his family 's dog. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NVJLRr

Mr John Jago 05 June 1940 –07 September 2018

Mr John Jago, formerly consultant maxillofacial surgeon at Dumfries and Galloway Hospitals, died peacefully at a hospital in southwest France on 7 September 2018, following a short illness. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NYogPZ

Multicentre approach to epidemiological aspects of craniosynostosis in Germany

We know of no current published data on the prevalence of craniosynostosis in Germany, so our objective in this study was to contribute to the limited knowledge of its epidemiology by assessing time trends, the frequency of prenatal diagnosis, and the timing of diagnosis and treatment. Data were collected in Saxony-Anhalt during the period 2000 –17, and we designed a retrospective multicentre cohort study. The prevalence was 4.8 cases of craniosynostosis/10 000 births, and did not increase during that time. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Cytotoxicity and Pro-/Anti-inflammatory Properties of Cinnamates, Acrylates and Methacrylates Against RAW264.7 Cells

Conclusion: Cinnamaldehyde and acrylates exhibited both anti-inflammatory and pro-inflammatory properties, possibly due to their marked ability to act as Michael reaction acceptors, as estimated from the beta-carbon 13C-nuclear magnetic resonance spectra. Methyl cinnamate exhibited potent anti-inflammatory activity with less cytotoxicity and pro-inflammatory activity, suggesting that this compound may be useful for treatment of periodontal disease and related systemic diseases. (Source: In Vivo)

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Cytotoxicity and Pro-/Anti-inflammatory Properties of Cinnamates, Acrylates and Methacrylates Against RAW264.7 Cells

Conclusion: Cinnamaldehyde and acrylates exhibited both anti-inflammatory and pro-inflammatory properties, possibly due to their marked ability to act as Michael reaction acceptors, as estimated from the beta-carbon 13C-nuclear magnetic resonance spectra. Methyl cinnamate exhibited potent anti-inflammatory activity with less cytotoxicity and pro-inflammatory activity, suggesting that this compound may be useful for treatment of periodontal disease and related systemic diseases. (Source: In Vivo)

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Anatomical characteristics of maxillary sinus septa visualized by cone beam computed tomography

Proper implant positioning in the posterior region of the edentulous maxilla commonly requires sinus floor elevation. Maxillary sinus septa increase the risk of membrane perforation during sinus floor elevation. The purpose of this retrospective, cone beam computed tomography (CBCT)-based study was to examine the frequency, number, location, and orientation of antral septa in the maxillary sinus. Further, possible associated factors were assessed. Measurements were performed on CBCT scans of 301 patients (602 sinuses). (Source: International Journal of Oral and Maxillofacial Surgery)

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Anatomical characteristics of maxillary sinus septa visualized by cone beam computed tomography

Proper implant positioning in the posterior region of the edentulous maxilla commonly requires sinus floor elevation. Maxillary sinus septa increase the risk of membrane perforation during sinus floor elevation. The purpose of this retrospective, cone beam computed tomography (CBCT)-based study was to examine the frequency, number, location, and orientation of antral septa in the maxillary sinus. Further, possible associated factors were assessed. Measurements were performed on CBCT scans of 301 patients (602 sinuses). (Source: International Journal of Oral and Maxillofacial Surgery)

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Teal Pumpkins Mark Allergy Safe Halloween Stops

It's now estimated that 4 million to 6 million children under the age of 18 have food allergies, meaning 1 in every 13 children are restricted in what they can safely eat. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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EU Panel Backs Drug for Rare Hereditary Angioedema EU Panel Backs Drug for Rare Hereditary Angioedema

Lanadelumab would be the first monoclonal antibody for preventing recurrent attacks of HAE in patients ages 12 years and older.International Approvals (Source: Medscape Medical News Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R81rLU

Think you're allergic to penicillin? Think again

People with penicillin allergies are more likely to get antibiotic-resistant infections such as C.difficile or MRSA, which can be life-threatening - yet 90 per cent are wrongly diagnosed. (Source: the Mail online | Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q4ydSn

Teal Pumpkins Mark Allergy Safe Halloween Stops

It's now estimated that 4 million to 6 million children under the age of 18 have food allergies, meaning 1 in every 13 children are restricted in what they can safely eat. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q73eFe

EU Panel Backs Drug for Rare Hereditary Angioedema EU Panel Backs Drug for Rare Hereditary Angioedema

Lanadelumab would be the first monoclonal antibody for preventing recurrent attacks of HAE in patients ages 12 years and older.International Approvals (Source: Medscape Medical News Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R81rLU

Think you're allergic to penicillin? Think again

People with penicillin allergies are more likely to get antibiotic-resistant infections such as C.difficile or MRSA, which can be life-threatening - yet 90 per cent are wrongly diagnosed. (Source: the Mail online | Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q4ydSn

Pharmacological neuroenhancement and the ability to recover from stress – a representative cross-sectional survey among the German population

Pharmacological neuroenhancement (PNE) refers to the use of psychoactive substances without doctor's prescription to enhance cognitive performance or to improve mood. Although some studies have reported that d...

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Apovitellin identified as a novel major egg allergen in goose egg allergy

Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)

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Structured intervention plan including component ‐resolved diagnostics helps reducing the burden of food allergy among school‐aged children

Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3r0fe

Pharmacological neuroenhancement and the ability to recover from stress – a representative cross-sectional survey among the German population

Pharmacological neuroenhancement (PNE) refers to the use of psychoactive substances without doctor's prescription to enhance cognitive performance or to improve mood. Although some studies have reported that d...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R38Eg2

Apovitellin identified as a novel major egg allergen in goose egg allergy

Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OHLP4L

Structured intervention plan including component ‐resolved diagnostics helps reducing the burden of food allergy among school‐aged children

Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3r0fe

Teal Pumpkins Mark Allergy Safe Halloween Stops

It's now estimated that 4 million to 6 million children under the age of 18 have food allergies, meaning 1 in every 13 children are restricted in what they can safely eat. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q73eFe

EU Panel Backs Drug for Rare Hereditary Angioedema EU Panel Backs Drug for Rare Hereditary Angioedema

Lanadelumab would be the first monoclonal antibody for preventing recurrent attacks of HAE in patients ages 12 years and older.International Approvals (Source: Medscape Medical News Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R81rLU

Think you're allergic to penicillin? Think again

People with penicillin allergies are more likely to get antibiotic-resistant infections such as C.difficile or MRSA, which can be life-threatening - yet 90 per cent are wrongly diagnosed. (Source: the Mail online | Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q4ydSn

Penn researchers land $10.7M grant to study CAR-T cell therapy in solid tumors

The University of Pennsylvania's Abramson Cancer Center had received a $10.7 million grant from the National Cancer Institute to study CAR-T cells in solid tumors The five-year grant from the NCI's will support new experimental approaches in lung cancer and mesothelioma being conducted by Penn researchers at its translational center of excellence for lung cancer immunology "Although CAR-T cells have been revolutionized the treatment of leukemia and bone marrow cancers, we have not yet had the… (Source: bizjournals.com Health Care:Physician Practices headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R5SnHq

Teal Pumpkins Mark Allergy Safe Halloween Stops

It's now estimated that 4 million to 6 million children under the age of 18 have food allergies, meaning 1 in every 13 children are restricted in what they can safely eat. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q73eFe

EU Panel Backs Drug for Rare Hereditary Angioedema EU Panel Backs Drug for Rare Hereditary Angioedema

Lanadelumab would be the first monoclonal antibody for preventing recurrent attacks of HAE in patients ages 12 years and older.International Approvals (Source: Medscape Medical News Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R81rLU

Think you're allergic to penicillin? Think again

People with penicillin allergies are more likely to get antibiotic-resistant infections such as C.difficile or MRSA, which can be life-threatening - yet 90 per cent are wrongly diagnosed. (Source: the Mail online | Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q4ydSn

Penn researchers land $10.7M grant to study CAR-T cell therapy in solid tumors

The University of Pennsylvania's Abramson Cancer Center had received a $10.7 million grant from the National Cancer Institute to study CAR-T cells in solid tumors The five-year grant from the NCI's will support new experimental approaches in lung cancer and mesothelioma being conducted by Penn researchers at its translational center of excellence for lung cancer immunology "Although CAR-T cells have been revolutionized the treatment of leukemia and bone marrow cancers, we have not yet had the… (Source: bizjournals.com Health Care:Physician Practices headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R5SnHq

Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma

This long-term extension study of mepolizumab in patients with severe eosinophilic asthma (exposure ≤4.5 years) identified no new safety concerns. Safety, immunogenicity, and efficacy profiles were durable and similar to previous, placebo-controlled clinical trials. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NWEJEn

Advances in Atopic Dermatitis in 2017

This review encompasses relevant scientific and clinical advances in atopic dermatitis published in 2017. These include articles from the Journal as well as other prominent publications that have contributed to the emerging field of the microenvironment of the skin and molecular patterns guiding biologic treatment strategies. The most commonly questioned and explored themes of the year included the impact of the microbiome on atopic dermatitis development as well as cell signaling and severity of symptoms. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OL9aCH

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

A novel PCR assay detected IgE M1 prime transcripts in nasal polyps of patients with CRSwNP and asthma, confirming that IgE switching occurred and membrane IgE-expressing B cells were resident at mucosal sites. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OFKJH0

Influenza Immunization in Common Variable Immunodeficiency

(Source: Journal of Allergy and Clinical Immunology)

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Prenatal 25-hydroxyvitamin D deficiency affects development of atopic dermatitis via DNA methylation

Due to the hypomethylation and consequently increased expression of oxidative stress-promoting genes in severely vitamin D-deficient fetus, the resulting offspring is predisposed to subsequent AD development and its severity. (Source: Journal of Allergy and Clinical Immunology)

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Award-Winning Research— IAO 2018

Int Arch Otorhinolaryngol 2018; 22: 335-335
DOI: 10.1055/s-0038-1673376

Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Article in Thieme eJournals:
Table of contents  |  open access Full text

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Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma

This long-term extension study of mepolizumab in patients with severe eosinophilic asthma (exposure ≤4.5 years) identified no new safety concerns. Safety, immunogenicity, and efficacy profiles were durable and similar to previous, placebo-controlled clinical trials. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NWEJEn

Advances in Atopic Dermatitis in 2017

This review encompasses relevant scientific and clinical advances in atopic dermatitis published in 2017. These include articles from the Journal as well as other prominent publications that have contributed to the emerging field of the microenvironment of the skin and molecular patterns guiding biologic treatment strategies. The most commonly questioned and explored themes of the year included the impact of the microbiome on atopic dermatitis development as well as cell signaling and severity of symptoms. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OL9aCH

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

A novel PCR assay detected IgE M1 prime transcripts in nasal polyps of patients with CRSwNP and asthma, confirming that IgE switching occurred and membrane IgE-expressing B cells were resident at mucosal sites. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OFKJH0

Influenza Immunization in Common Variable Immunodeficiency

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OyDoJ8

Prenatal 25-hydroxyvitamin D deficiency affects development of atopic dermatitis via DNA methylation

Due to the hypomethylation and consequently increased expression of oxidative stress-promoting genes in severely vitamin D-deficient fetus, the resulting offspring is predisposed to subsequent AD development and its severity. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOs5Y4

Five hundred patients reporting on adverse effects from dental materials: Frequencies, complaints, symptoms, allergies

Information on patients with real or claimed adverse reactions towards dental materials in large patient cohorts is rare. Therefore, the aim of the present study was to investigate patients reporting on complaints and symptoms to dental materials over a 16-year period. (Source: Dental Materials)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NXtziT

Legends of Allergology: Alfred William (Bill) Frankland

Allergy, EarlyView. (Source: Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OH1a5J

Milk and egg intervention during pregnancy and allergic disease in offspring up to 30 years of age

Allergy, EarlyView. (Source: Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NYpqLw

Apovitellin identified as a novel major egg allergen in goose egg allergy

Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OHLP4L

Structured intervention plan including component ‐resolved diagnostics helps reducing the burden of food allergy among school‐aged children

Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3r0fe

The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function

Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. (Source: Journal of Neuroimmunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OH191F

ZNF580 – a brake on Interleukin-6

Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 coul... (Source: Journal of Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3qSfK

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

A novel PCR assay detected IgE M1 prime transcripts in nasal polyps of patients with CRSwNP and asthma, confirming that IgE switching occurred and membrane IgE-expressing B cells were resident at mucosal sites. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OFKJH0

Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma

This long-term extension study of mepolizumab in patients with severe eosinophilic asthma (exposure ≤4.5 years) identified no new safety concerns. Safety, immunogenicity, and efficacy profiles were durable and similar to previous, placebo-controlled clinical trials. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NWEJEn

Advances in Atopic Dermatitis in 2017

This review encompasses relevant scientific and clinical advances in atopic dermatitis published in 2017. These include articles from the Journal as well as other prominent publications that have contributed to the emerging field of the microenvironment of the skin and molecular patterns guiding biologic treatment strategies. The most commonly questioned and explored themes of the year included the impact of the microbiome on atopic dermatitis development as well as cell signaling and severity of symptoms. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OL9aCH

Immunologic consequences of antimalarial chemoprevention

Date: Tuesday, 11 13, 2018; Speaker: Prasanna Jagannathan, Assistant Professor, Stanford University ; 5625 Fishers Lane; 5th Floor (Source: NIH Calendar of Events)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Immunometabolism

Date: Thursday, 10 25, 2018; Speaker: Luke O'Neill, Trinity College Dublin, Ireland , Krebs Cycle reprogrammed for cytokines, Trinity College Dublin, Ireland ; Iain Fraser, Role for mitochondrial NDP kinases in inflammasome activation, (NIAID) ; Amy Weinmann, Connections between metabolites, epigenetics, and genome organization in T cells, University of Alabama at Birmigham; Naomi Taylor, Metabolite orchestration of T cell differentiation and function, NCI; Ed Pearce, Metabolic compensation for self-inflicted damage during macrophage activation, The Max Planck Institute of Immunobiology and Epigenetics, Germany; Catharine Bosio, IFN-g drives host metabolism to control bacterial replication independent of ROS, NIAID; Jonathan Powell, Dissecting tumor metabolism from immunometabolism, Johns ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OEdbZE

Five hundred patients reporting on adverse effects from dental materials: Frequencies, complaints, symptoms, allergies

Information on patients with real or claimed adverse reactions towards dental materials in large patient cohorts is rare. Therefore, the aim of the present study was to investigate patients reporting on complaints and symptoms to dental materials over a 16-year period. (Source: Dental Materials)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NXtziT

Legends of Allergology: Alfred William (Bill) Frankland

Allergy, EarlyView. (Source: Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OH1a5J

Milk and egg intervention during pregnancy and allergic disease in offspring up to 30 years of age

Allergy, EarlyView. (Source: Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NYpqLw

Apovitellin identified as a novel major egg allergen in goose egg allergy

Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OHLP4L

Structured intervention plan including component ‐resolved diagnostics helps reducing the burden of food allergy among school‐aged children

Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3r0fe

The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function

Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. (Source: Journal of Neuroimmunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OH191F

ZNF580 – a brake on Interleukin-6

Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 coul... (Source: Journal of Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3qSfK

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

A novel PCR assay detected IgE M1 prime transcripts in nasal polyps of patients with CRSwNP and asthma, confirming that IgE switching occurred and membrane IgE-expressing B cells were resident at mucosal sites. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OFKJH0

Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma

This long-term extension study of mepolizumab in patients with severe eosinophilic asthma (exposure ≤4.5 years) identified no new safety concerns. Safety, immunogenicity, and efficacy profiles were durable and similar to previous, placebo-controlled clinical trials. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NWEJEn

Advances in Atopic Dermatitis in 2017

This review encompasses relevant scientific and clinical advances in atopic dermatitis published in 2017. These include articles from the Journal as well as other prominent publications that have contributed to the emerging field of the microenvironment of the skin and molecular patterns guiding biologic treatment strategies. The most commonly questioned and explored themes of the year included the impact of the microbiome on atopic dermatitis development as well as cell signaling and severity of symptoms. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OL9aCH

Immunologic consequences of antimalarial chemoprevention

Date: Tuesday, 11 13, 2018; Speaker: Prasanna Jagannathan, Assistant Professor, Stanford University ; 5625 Fishers Lane; 5th Floor (Source: NIH Calendar of Events)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NYppXY

Immunometabolism

Date: Thursday, 10 25, 2018; Speaker: Luke O'Neill, Trinity College Dublin, Ireland , Krebs Cycle reprogrammed for cytokines, Trinity College Dublin, Ireland ; Iain Fraser, Role for mitochondrial NDP kinases in inflammasome activation, (NIAID) ; Amy Weinmann, Connections between metabolites, epigenetics, and genome organization in T cells, University of Alabama at Birmigham; Naomi Taylor, Metabolite orchestration of T cell differentiation and function, NCI; Ed Pearce, Metabolic compensation for self-inflicted damage during macrophage activation, The Max Planck Institute of Immunobiology and Epigenetics, Germany; Catharine Bosio, IFN-g drives host metabolism to control bacterial replication independent of ROS, NIAID; Jonathan Powell, Dissecting tumor metabolism from immunometabolism, Johns ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OEdbZE

Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma

This long-term extension study of mepolizumab in patients with severe eosinophilic asthma (exposure ≤4.5 years) identified no new safety concerns. Safety, immunogenicity, and efficacy profiles were durable and similar to previous, placebo-controlled clinical trials.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yTwEe3

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

A novel PCR assay detected IgE M1 prime transcripts in nasal polyps of patients with CRSwNP and asthma, confirming that IgE switching occurred and membrane IgE-expressing B cells were resident at mucosal sites.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2S6UdsK

Advances in Atopic Dermatitis in 2017

This review encompasses relevant scientific and clinical advances in atopic dermatitis published in 2017. These include articles from the Journal as well as other prominent publications that have contributed to the emerging field of the microenvironment of the skin and molecular patterns guiding biologic treatment strategies. The most commonly questioned and explored themes of the year included the impact of the microbiome on atopic dermatitis development as well as cell signaling and severity of symptoms.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yW3wDa

Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma

This long-term extension study of mepolizumab in patients with severe eosinophilic asthma (exposure ≤4.5 years) identified no new safety concerns. Safety, immunogenicity, and efficacy profiles were durable and similar to previous, placebo-controlled clinical trials.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yTwEe3

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

A novel PCR assay detected IgE M1 prime transcripts in nasal polyps of patients with CRSwNP and asthma, confirming that IgE switching occurred and membrane IgE-expressing B cells were resident at mucosal sites.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2S6UdsK

Advances in Atopic Dermatitis in 2017

This review encompasses relevant scientific and clinical advances in atopic dermatitis published in 2017. These include articles from the Journal as well as other prominent publications that have contributed to the emerging field of the microenvironment of the skin and molecular patterns guiding biologic treatment strategies. The most commonly questioned and explored themes of the year included the impact of the microbiome on atopic dermatitis development as well as cell signaling and severity of symptoms.

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Patients With OUD Who Receive Extended-Release Naltrexone May Be More Likely to Stay in Treatment

Naltrexone is a proven treatment for opioid use disorder (OUD), but its clinical usefulness, when taken orally, has been limited by poor adherence among patients, according to several studies. Astudy inAJP in Advance now suggests that patients with OUD may be twice as likely to stay in therapy if they receive monthly injections of extended-release naltrexone (XR-naltrexone) following opioid withdrawal compared with daily oral naltrexone."These study findings have immediate clinical relevance for treatment of opioid use disorder at a time when an opioid epidemic continues unabated in the United States," wrote Maria Sullivan, M.D., Ph.D., of Columbia University and colleagues. "Given that postdetoxification outpatient treatment without pharmacotherapy yields poor completion rates, high...

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Efficacy comparison between long-term high-dose praziquantel and surgical therapy for cerebral sparganosis: A multicenter retrospective cohort study

Conclusions/SignificanceIn this small-sample, nonrandomized, retrospective exploratory study, some patients with cerebral sparganosis were responsive to long-term, high-dose praziquantel with an efficacy similar to that of surgical lesion removal. These findings increase the treatment flexibility for this serious infection. (Source: PLoS Neglected Tropical Diseases)

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Patients With OUD Who Receive Extended-Release Naltrexone May Be More Likely to Stay in Treatment

Naltrexone is a proven treatment for opioid use disorder (OUD), but its clinical usefulness, when taken orally, has been limited by poor adherence among patients, according to several studies. Astudy inAJP in Advance now suggests that patients with OUD may be twice as likely to stay in therapy if they receive monthly injections of extended-release naltrexone (XR-naltrexone) following opioid withdrawal compared with daily oral naltrexone."These study findings have immediate clinical relevance for treatment of opioid use disorder at a time when an opioid epidemic continues unabated in the United States," wrote Maria Sullivan, M.D., Ph.D., of Columbia University and colleagues. "Given that postdetoxification outpatient treatment without pharmacotherapy yields poor completion rates, high...

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Efficacy comparison between long-term high-dose praziquantel and surgical therapy for cerebral sparganosis: A multicenter retrospective cohort study

Conclusions/SignificanceIn this small-sample, nonrandomized, retrospective exploratory study, some patients with cerebral sparganosis were responsive to long-term, high-dose praziquantel with an efficacy similar to that of surgical lesion removal. These findings increase the treatment flexibility for this serious infection. (Source: PLoS Neglected Tropical Diseases)

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Anatomical characteristics of maxillary sinus septa visualized by cone beam computed tomography

Proper implant positioning in the posterior region of the edentulous maxilla commonly requires sinus floor elevation. Maxillary sinus septa increase the risk of membrane perforation during sinus floor elevation. The purpose of this retrospective, cone beam computed tomography (CBCT)-based study was to examine the frequency, number, location, and orientation of antral septa in the maxillary sinus. Further, possible associated factors were assessed. Measurements were performed on CBCT scans of 301 patients (602 sinuses).

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Multicentre approach to epidemiological aspects of craniosynostosis in Germany

We know of no current published data on the prevalence of craniosynostosis in Germany, so our objective in this study was to contribute to the limited knowledge of its epidemiology by assessing time trends, the frequency of prenatal diagnosis, and the timing of diagnosis and treatment. Data were collected in Saxony-Anhalt during the period 2000–17, and we designed a retrospective multicentre cohort study. The prevalence was 4.8 cases of craniosynostosis/10 000 births, and did not increase during that time.

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Mr John Jago 05 June 1940–07 September 2018

Mr John Jago, formerly consultant maxillofacial surgeon at Dumfries and Galloway Hospitals, died peacefully at a hospital in southwest France on 7 September 2018, following a short illness.

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Anatomical characteristics of maxillary sinus septa visualized by cone beam computed tomography

Proper implant positioning in the posterior region of the edentulous maxilla commonly requires sinus floor elevation. Maxillary sinus septa increase the risk of membrane perforation during sinus floor elevation. The purpose of this retrospective, cone beam computed tomography (CBCT)-based study was to examine the frequency, number, location, and orientation of antral septa in the maxillary sinus. Further, possible associated factors were assessed. Measurements were performed on CBCT scans of 301 patients (602 sinuses).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OE2HJT

Multicentre approach to epidemiological aspects of craniosynostosis in Germany

We know of no current published data on the prevalence of craniosynostosis in Germany, so our objective in this study was to contribute to the limited knowledge of its epidemiology by assessing time trends, the frequency of prenatal diagnosis, and the timing of diagnosis and treatment. Data were collected in Saxony-Anhalt during the period 2000–17, and we designed a retrospective multicentre cohort study. The prevalence was 4.8 cases of craniosynostosis/10 000 births, and did not increase during that time.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CC0CXo

Mr John Jago 05 June 1940–07 September 2018

Mr John Jago, formerly consultant maxillofacial surgeon at Dumfries and Galloway Hospitals, died peacefully at a hospital in southwest France on 7 September 2018, following a short illness.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AmDPgN

Dissect the mode of action of probiotics in affecting host-microbial interactions and immunity in food producing animals

Publication date: Available online 22 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Tao Ma, Yutaka Suzuki, Le Luo GuanAbstractProphylactic antimicrobials have been widely used in food animal production with the aim to prevent infectious diseases, enhance feed efficiency, and promote growth. However, the extensive use of antimicrobials in food animal production systems has led to the emergence of antimicrobial resistant pathogens, which are potential threats to human and animal health. Probiotics have been proposed to be a promising alternative of prophylactic antimicrobials, with potential beneficial effects on the host animal by improving the balance of intestinal microbiota and host immunity. Although an increasing body of evidence shows that probiotics could di...

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Dissect the mode of action of probiotics in affecting host-microbial interactions and immunity in food producing animals

Publication date: Available online 22 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Tao Ma, Yutaka Suzuki, Le Luo GuanAbstractProphylactic antimicrobials have been widely used in food animal production with the aim to prevent infectious diseases, enhance feed efficiency, and promote growth. However, the extensive use of antimicrobials in food animal production systems has led to the emergence of antimicrobial resistant pathogens, which are potential threats to human and animal health. Probiotics have been proposed to be a promising alternative of prophylactic antimicrobials, with potential beneficial effects on the host animal by improving the balance of intestinal microbiota and host immunity. Although an increasing body of evidence shows that probiotics could di...

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Transcending Dimensions: a Comparative Analysis of Cloaca Imaging in Advancing the Surgeon’s Understanding of Complex Anatomy

Abstract

Surgeons have a steep learning capacity to understand 2-D images provided by conventional cloacagrams. Imaging advances now allow for 3-D reconstruction and 3-D models; but no evaluation of the value of these techniques exists in the literature. Therefore, we sought to determine if advances in 3-D imaging would benefit surgeons, lead to accelerated learning, and improve understanding for operative planning of a cloaca reconstruction. Questionnaires were used to assess the understanding of 2-D and 3-D images by pediatric surgical faculty and trainees. For the same case of a cloacal malformation, a 2D contrast study cloacagram, a 3D model rotatable CT scan reconstruction, a software enhanced 3D video animation (which allowed the observer to manipulate the structure in any orientation), and a printed physical 3D cloaca model that could be held in the observer's hand were employed. Logistic mixed effect models assessed whether the proportion of questions about the case that were answered correctly differed by imaging modality, and whether the proportion answered correctly differed between trainee and attending surgeons for any particular modality. Twenty-nine pediatric surgery trainees (27 pediatric general surgery and 2 pediatric urology surgery trainees) and 30 pediatric surgery and urology faculty participated. For trainees, the percentage of questions answered correctly was: 2-D 10.5%, 3-D PACS 46.7%, 3-D Enhanced 67.1%, and 3-D Printed 73.8%. For faculty, the total percentage of questions answered correctly was: 2-D 22.2%, 3-D PACS 54.8%, 3D Enhanced 66.2%, and 3-D printed 74.0%. The differences in rates of correctness across all four modalities were significant in both fellows and attendings (p < 0.001), with performance being lowest for the 2-D modality, and with increasing percentage of correct answers with each subsequent modality. The difference between trainees and attendings in correctness rate was significant only for the 2-D modality, with attendings answering correctly more often. The 2-D cloacagram, as the least complex model, was the most difficult to interpret. The more complex the modality, the more correct were the responses obtained from both groups. Trainees and attendings had similar levels of correct answers and understanding of the cloacagram for the more advanced modalities. Mental visualization skills of anatomy and complex 3-D spatial arrangements traditionally have taken years of experience to master. Now with novel surgical education resources of a 3-D cloacagram, a more quickly advancing skill is possible.

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Transcending Dimensions: a Comparative Analysis of Cloaca Imaging in Advancing the Surgeon’s Understanding of Complex Anatomy

Abstract

Surgeons have a steep learning capacity to understand 2-D images provided by conventional cloacagrams. Imaging advances now allow for 3-D reconstruction and 3-D models; but no evaluation of the value of these techniques exists in the literature. Therefore, we sought to determine if advances in 3-D imaging would benefit surgeons, lead to accelerated learning, and improve understanding for operative planning of a cloaca reconstruction. Questionnaires were used to assess the understanding of 2-D and 3-D images by pediatric surgical faculty and trainees. For the same case of a cloacal malformation, a 2D contrast study cloacagram, a 3D model rotatable CT scan reconstruction, a software enhanced 3D video animation (which allowed the observer to manipulate the structure in any orientation), and a printed physical 3D cloaca model that could be held in the observer's hand were employed. Logistic mixed effect models assessed whether the proportion of questions about the case that were answered correctly differed by imaging modality, and whether the proportion answered correctly differed between trainee and attending surgeons for any particular modality. Twenty-nine pediatric surgery trainees (27 pediatric general surgery and 2 pediatric urology surgery trainees) and 30 pediatric surgery and urology faculty participated. For trainees, the percentage of questions answered correctly was: 2-D 10.5%, 3-D PACS 46.7%, 3-D Enhanced 67.1%, and 3-D Printed 73.8%. For faculty, the total percentage of questions answered correctly was: 2-D 22.2%, 3-D PACS 54.8%, 3D Enhanced 66.2%, and 3-D printed 74.0%. The differences in rates of correctness across all four modalities were significant in both fellows and attendings (p < 0.001), with performance being lowest for the 2-D modality, and with increasing percentage of correct answers with each subsequent modality. The difference between trainees and attendings in correctness rate was significant only for the 2-D modality, with attendings answering correctly more often. The 2-D cloacagram, as the least complex model, was the most difficult to interpret. The more complex the modality, the more correct were the responses obtained from both groups. Trainees and attendings had similar levels of correct answers and understanding of the cloacagram for the more advanced modalities. Mental visualization skills of anatomy and complex 3-D spatial arrangements traditionally have taken years of experience to master. Now with novel surgical education resources of a 3-D cloacagram, a more quickly advancing skill is possible.

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Pluripotent stem cell-derived cochlear cells: a challenge in constant progress.

Authors: Czajkowski A, Mounier A, Delacroix L, Malgrange B Abstract Hearing loss is a common affection mainly resulting from irreversible loss of the sensory hair cells of the cochlea; therefore, developing therapies to replace missing hair cells is essential. Understanding the mechanisms that drive their formation will not only help to unravel the molecular basis of deafness, but also give a roadmap for recapitulating hair cells development from cultured pluripotent stem cells. In this review, we provide an overview of the molecular mechanisms involved in hair cell production from both human and mouse embryonic stem cells. We then provide insights how this knowledge has been applied to differentiate induced pluripotent stem cells into otic progenitors and hair cells. Finally, we d...

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Pluripotent stem cell-derived cochlear cells: a challenge in constant progress.

Authors: Czajkowski A, Mounier A, Delacroix L, Malgrange B Abstract Hearing loss is a common affection mainly resulting from irreversible loss of the sensory hair cells of the cochlea; therefore, developing therapies to replace missing hair cells is essential. Understanding the mechanisms that drive their formation will not only help to unravel the molecular basis of deafness, but also give a roadmap for recapitulating hair cells development from cultured pluripotent stem cells. In this review, we provide an overview of the molecular mechanisms involved in hair cell production from both human and mouse embryonic stem cells. We then provide insights how this knowledge has been applied to differentiate induced pluripotent stem cells into otic progenitors and hair cells. Finally, we d...

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Manage your allergic rhinitis with Yu ping feng san, a Chinese herbal medicine

(Natural News) Allergic rhinitis, which is often triggered by allergen exposure, is a common nasal problem affecting adults. In Chinese herbal medicine, Yu ping feng san has been used to treat this problem. A study published in the journal BMC Complementary and Alternative Medicine has proven that Yu ping feng san is a safe and... (Source: NaturalNews.com)

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Abramson Cancer Center receives $10.7 million to study CAR T cells in solid tumors

(University of Pennsylvania School of Medicine) A new program project grant from the National Cancer Institute (NCI) will fund research by the Translational Center of Excellence for Lung Cancer Immunology at the Abramson Cancer Center of the University of Pennsylvania to improve the effectiveness of chimeric antigen receptor (CAR) T cell therapy at fighting solid tumors. (Source: EurekAlert! - Medicine and Health)

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Cedar ’ s Mediterranean Foods Issues Allergy Alert on Undeclared Soy in Cedar ’ s Chickpea Salad 8 oz.

Cedar ' s Mediterranean Foods, of Ward Hill, MA is voluntarily recalling Cedar ' s Chickpea Salad 8 oz. because it may contain undeclared edamame (soy). People who have an allergy or severe sensitivity to soy run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

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Stewart ’ s Shops Issues Allergy Alert on Undeclared Milk in Cranberry Apple Refresher

Saratoga Springs, NY - Stewart ' s Shops Corp. is recalling units of Stewart ' s Shops brand Cranberry Apple Refresher 16 fluid oz. because the product may contain undeclared milk.   People who have an allergy to milk run the risk of serious or life-threatening allergic reaction if they consume this product. Approximately 2,300 units of affected product were distributed in upstate New York and Southern Vermont. (Source: Food and Drug Administration)

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Manage your allergic rhinitis with Yu ping feng san, a Chinese herbal medicine

(Natural News) Allergic rhinitis, which is often triggered by allergen exposure, is a common nasal problem affecting adults. In Chinese herbal medicine, Yu ping feng san has been used to treat this problem. A study published in the journal BMC Complementary and Alternative Medicine has proven that Yu ping feng san is a safe and... (Source: NaturalNews.com)

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Abramson Cancer Center receives $10.7 million to study CAR T cells in solid tumors

(University of Pennsylvania School of Medicine) A new program project grant from the National Cancer Institute (NCI) will fund research by the Translational Center of Excellence for Lung Cancer Immunology at the Abramson Cancer Center of the University of Pennsylvania to improve the effectiveness of chimeric antigen receptor (CAR) T cell therapy at fighting solid tumors. (Source: EurekAlert! - Medicine and Health)

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Cedar ’ s Mediterranean Foods Issues Allergy Alert on Undeclared Soy in Cedar ’ s Chickpea Salad 8 oz.

Cedar ' s Mediterranean Foods, of Ward Hill, MA is voluntarily recalling Cedar ' s Chickpea Salad 8 oz. because it may contain undeclared edamame (soy). People who have an allergy or severe sensitivity to soy run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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Stewart ’ s Shops Issues Allergy Alert on Undeclared Milk in Cranberry Apple Refresher

Saratoga Springs, NY - Stewart ' s Shops Corp. is recalling units of Stewart ' s Shops brand Cranberry Apple Refresher 16 fluid oz. because the product may contain undeclared milk.   People who have an allergy to milk run the risk of serious or life-threatening allergic reaction if they consume this product. Approximately 2,300 units of affected product were distributed in upstate New York and Southern Vermont. (Source: Food and Drug Administration)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CxfGFP

Manage your allergic rhinitis with Yu ping feng san, a Chinese herbal medicine

(Natural News) Allergic rhinitis, which is often triggered by allergen exposure, is a common nasal problem affecting adults. In Chinese herbal medicine, Yu ping feng san has been used to treat this problem. A study published in the journal BMC Complementary and Alternative Medicine has proven that Yu ping feng san is a safe and... (Source: NaturalNews.com)

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Abramson Cancer Center receives $10.7 million to study CAR T cells in solid tumors

(University of Pennsylvania School of Medicine) A new program project grant from the National Cancer Institute (NCI) will fund research by the Translational Center of Excellence for Lung Cancer Immunology at the Abramson Cancer Center of the University of Pennsylvania to improve the effectiveness of chimeric antigen receptor (CAR) T cell therapy at fighting solid tumors. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CxUsaN

Cedar ’ s Mediterranean Foods Issues Allergy Alert on Undeclared Soy in Cedar ’ s Chickpea Salad 8 oz.

Cedar ' s Mediterranean Foods, of Ward Hill, MA is voluntarily recalling Cedar ' s Chickpea Salad 8 oz. because it may contain undeclared edamame (soy). People who have an allergy or severe sensitivity to soy run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AmL3RY

Stewart ’ s Shops Issues Allergy Alert on Undeclared Milk in Cranberry Apple Refresher

Saratoga Springs, NY - Stewart ' s Shops Corp. is recalling units of Stewart ' s Shops brand Cranberry Apple Refresher 16 fluid oz. because the product may contain undeclared milk.   People who have an allergy to milk run the risk of serious or life-threatening allergic reaction if they consume this product. Approximately 2,300 units of affected product were distributed in upstate New York and Southern Vermont. (Source: Food and Drug Administration)

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Abstracts

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Manage your allergic rhinitis with Yu ping feng san, a Chinese herbal medicine

(Natural News) Allergic rhinitis, which is often triggered by allergen exposure, is a common nasal problem affecting adults. In Chinese herbal medicine, Yu ping feng san has been used to treat this problem. A study published in the journal BMC Complementary and Alternative Medicine has proven that Yu ping feng san is a safe and... (Source: NaturalNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AmOwA4

Abramson Cancer Center receives $10.7 million to study CAR T cells in solid tumors

(University of Pennsylvania School of Medicine) A new program project grant from the National Cancer Institute (NCI) will fund research by the Translational Center of Excellence for Lung Cancer Immunology at the Abramson Cancer Center of the University of Pennsylvania to improve the effectiveness of chimeric antigen receptor (CAR) T cell therapy at fighting solid tumors. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CxUsaN

Cedar ’ s Mediterranean Foods Issues Allergy Alert on Undeclared Soy in Cedar ’ s Chickpea Salad 8 oz.

Cedar ' s Mediterranean Foods, of Ward Hill, MA is voluntarily recalling Cedar ' s Chickpea Salad 8 oz. because it may contain undeclared edamame (soy). People who have an allergy or severe sensitivity to soy run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AmL3RY

Stewart ’ s Shops Issues Allergy Alert on Undeclared Milk in Cranberry Apple Refresher

Saratoga Springs, NY - Stewart ' s Shops Corp. is recalling units of Stewart ' s Shops brand Cranberry Apple Refresher 16 fluid oz. because the product may contain undeclared milk.   People who have an allergy to milk run the risk of serious or life-threatening allergic reaction if they consume this product. Approximately 2,300 units of affected product were distributed in upstate New York and Southern Vermont. (Source: Food and Drug Administration)

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Abstracts

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Left ventricular geometry and periodontitis in patients with the metabolic syndrome

Abstract

Objective

The presence of periodontal disease (PD) in subjects affected by the metabolic syndrome (MetS) may affect their risk of developing cardiovascular disease. The aim of this cross-sectional study was to investigate the systemic impact of PD in MetS, by assessing measures of sub-clinical atherosclerosis and left ventricular mass and geometry.

Materials and methods

A total of 103 patients undergoing treatment for MetS were examined for confirmation of diagnosis, blood sampling, and measures of pulse wave velocity (PWV), carotid intima-media thickness (c-IMT), left ventricular mass index (LVM), and relative wall thickness (RWT). All subjects underwent a detailed dental assessment, including measurements of DMFT (decayed-missing-filled teeth) and periodontal parameters.

Results

Ten patients (10%) were diagnosed with healthy-mild periodontitis, 38 patients (37%) were diagnosed in the moderate periodontitis group, and 55 (53%) had severe periodontitis. A total of 37% of subjects were affected by dental caries. Linear regression analysis revealed that patients with severe PD had increased average ventricular RWT (adjusted p = 0.032). Average full mouth probing pocket depth (PPD) was also associated with RWT (adjusted p = 0.006). No associations between PD and c-IMT, PWV, and LVM were detected after adjusted analyses.

Conclusion

This study suggests that periodontitis may be associated with concentric left ventricular remodeling, a predictive index of cardiovascular events.

Clinical relevance

The presence of periodontitis in patients with MetS might have an effect on left ventricular geometry. These findings stress the importance of prevention, diagnosis, and management of periodontitis in patients with MetS.

Trail registration

NCT03297749

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Radiomics in RayPlus: a Web-Based Tool for Texture Analysis in Medical Images

Abstract

Radiomics has been shown to have considerable potential and value in quantifying the tumor phenotype and predicting the treatment response. In most scenarios, the commercial and open-source software programs are available for quantitative analysis in medical images to streamline radiomics research. However, at this stage, most of these programs are local applications and require users to have experience in programming and software engineering, which clinicians usually do not have. Therefore, in this article, a web-based tool was proposed to flexibly support radiomics research workflow tasks. Radiomics in RayPlus requires zero installation, is easy to maintain, and accessible anywhere via any PC or MAC with an Internet connection. The system provides functions including multimodality image import and viewing, ROI definition, feature extraction, and data sharing. As a web application, it appears an effective way to multi-institution and multi-department collaborative radiomics research and moreover, its transparency, flexibility, and portability can greatly accelerate the pace of clinical data analysis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Jdtere

Left ventricular geometry and periodontitis in patients with the metabolic syndrome

Abstract

Objective

The presence of periodontal disease (PD) in subjects affected by the metabolic syndrome (MetS) may affect their risk of developing cardiovascular disease. The aim of this cross-sectional study was to investigate the systemic impact of PD in MetS, by assessing measures of sub-clinical atherosclerosis and left ventricular mass and geometry.

Materials and methods

A total of 103 patients undergoing treatment for MetS were examined for confirmation of diagnosis, blood sampling, and measures of pulse wave velocity (PWV), carotid intima-media thickness (c-IMT), left ventricular mass index (LVM), and relative wall thickness (RWT). All subjects underwent a detailed dental assessment, including measurements of DMFT (decayed-missing-filled teeth) and periodontal parameters.

Results

Ten patients (10%) were diagnosed with healthy-mild periodontitis, 38 patients (37%) were diagnosed in the moderate periodontitis group, and 55 (53%) had severe periodontitis. A total of 37% of subjects were affected by dental caries. Linear regression analysis revealed that patients with severe PD had increased average ventricular RWT (adjusted p = 0.032). Average full mouth probing pocket depth (PPD) was also associated with RWT (adjusted p = 0.006). No associations between PD and c-IMT, PWV, and LVM were detected after adjusted analyses.

Conclusion

This study suggests that periodontitis may be associated with concentric left ventricular remodeling, a predictive index of cardiovascular events.

Clinical relevance

The presence of periodontitis in patients with MetS might have an effect on left ventricular geometry. These findings stress the importance of prevention, diagnosis, and management of periodontitis in patients with MetS.

Trail registration

NCT03297749

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Radiomics in RayPlus: a Web-Based Tool for Texture Analysis in Medical Images

Abstract

Radiomics has been shown to have considerable potential and value in quantifying the tumor phenotype and predicting the treatment response. In most scenarios, the commercial and open-source software programs are available for quantitative analysis in medical images to streamline radiomics research. However, at this stage, most of these programs are local applications and require users to have experience in programming and software engineering, which clinicians usually do not have. Therefore, in this article, a web-based tool was proposed to flexibly support radiomics research workflow tasks. Radiomics in RayPlus requires zero installation, is easy to maintain, and accessible anywhere via any PC or MAC with an Internet connection. The system provides functions including multimodality image import and viewing, ROI definition, feature extraction, and data sharing. As a web application, it appears an effective way to multi-institution and multi-department collaborative radiomics research and moreover, its transparency, flexibility, and portability can greatly accelerate the pace of clinical data analysis.

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Assessing the effect of multibracket appliance treatment on tooth color by using electronic measurement

Abstract

Background

The purpose of this study was to investigate how tooth color is affected by multibracket appliance (MBA) treatment.

Methods

The color of teeth #14 to #24 of 15 patients with MBA was measured on body and gingival tooth segments using the spectrophotometer Shade Inspector™. Colors of both segments were recorded before start of MBA treatment (baseline T₀), end of MBA treatment (T₁; 2 years ±0.3), and 3 months after T₁ (T₂). A 2D color system and a 3D system served as reference systems.

Multilevel models were used to analyze color change within segments and to compare the difference in color change between segments (treatment effect).

Results

2D system. Changes within tooth segments from T₀ to T₂ were at worst 2.0 units (ΔE in the gingival segment), which is less than the threshold of 2.7 units for a clinically meaningful difference. Confidence intervals for the treatment effect indicated no clinically important differences in color change between body and gingival segments.

3D system. Changes within tooth segments from T₀ to T₂ were at worst 2.3 units (ΔE in the body segment), which is less than the threshold of 2.7 units for a clinically meaningful difference. Confidence intervals for the treatment effect indicated no clinically important differences in color change between body and gingival segments.

Thus, MBA treatment did not lead to clinically relevant changes in tooth color.

Conclusion

Within the limitation of this study the MBA treatment can be seen as a safe method with respect to tooth color.

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Use of acid suppressive medications and antibiotics in young infants is associated with development of allergic disease

Mitre E, Susi A, Kropp LE, Schwartz DJ, Gorman GH, Nylund CM. Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood. JAMA Pediatr 2018;172:e180315. (Source: The Journal of Pediatrics)

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