Immunologic characterization of patients with chronic mucocutaneous candidiasis disease

Even if initial immunologic screen is normal, a high index of suspicion for immunodeficiency should guide the evaluation and management of patients with recurrent episodes of mucocutaneous candidiasis. Although rare, a diagnosis of chronic mucocutaneous disease should always be considered in order to improve their outcome. Key Clinical MessageEven if initial immunologic screen is normal, a high index of suspicion for immunodeficiency should guide the evaluation and management of patients with recurrent episodes of mucocutaneous candidiasis. Although rare, a diagnosis of chronic mucocutaneous disease should always be considered in order to improve their outcome. (Source: Clinical Case Reports)

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Immunologic characterization of patients with chronic mucocutaneous candidiasis disease

Even if initial immunologic screen is normal, a high index of suspicion for immunodeficiency should guide the evaluation and management of patients with recurrent episodes of mucocutaneous candidiasis. Although rare, a diagnosis of chronic mucocutaneous disease should always be considered in order to improve their outcome. Key Clinical MessageEven if initial immunologic screen is normal, a high index of suspicion for immunodeficiency should guide the evaluation and management of patients with recurrent episodes of mucocutaneous candidiasis. Although rare, a diagnosis of chronic mucocutaneous disease should always be considered in order to improve their outcome. (Source: Clinical Case Reports)

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Pain therapy for the elderly patient: is opioid-free an option?

Purpose of review Chronic noncancer pain is an increasing problem in elderly because of rising life expectancy together with an increase of potentially painful medical conditions. Concomitantly, adequate treatment of elderly is often limited by coexisting diseases and polypharmacy.This review summarizes the most important specifics presented by elderly patients and discusses the pharmacological and nonpharmacological options of pain management. Recent findings A comprehensive pain assessment is a prerequisite for effective pain management. However, this can be a major challenge in patients who are unable to communicate adequately, that is, in patients with dementia. A recently developed electronic tool assessing automated facial expression and clinical behavioral indicators may help to solve this problem. The discussion about benefits and harms of opioids in elderly goes on. Although some authors underline the lack of efficacy together with the potential problems, such as, abuse, others report a beneficial effect in terms of pain relief, functional activities and disability. In addition, opioids have become an important treatment option in patients with restless legs syndrome. Various topical treatment options (i.e. capsaicin patch) and nonpharmacological interventions have been proven to be beneficial in elderly. Summary Adequate pain management of elderly patients constitutes numerous pharmacological options including nonopioids, opioids, coanalgesics and topical agents. Due to age-related characteristics, all systemic analgesics have to be given very cautiously ('start low, go slow'). Whenever possible, treatment should be performed as a multimodal approach based on the biopsychosocial model of chronic pain. Correspondence to Shahnaz Christina Azad, MD, PhD, Department of Anesthesiology and Pain Medicine, Ludwig-Maximilians University Munich, Marchioninistr. 15, 81377 Munich, Germany. Tel: +49 89440074464; fax: +49 89440074469; e-mail: shahnaz.azad@med.uni-muenchen.de Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.

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Ergonomics in endoscopic sinus surgery

Purpose of review Awareness of ergonomics is growing into surgical specialties including otolaryngology. Most otolaryngologists experience occupational physical discomfort, and daily incorporation of standard ergonomic principles may alleviate some of this pain. Recent findings Further demonstration of surgery-related physical discomfort has been documented based on surveys of general otolaryngologists and subspecialty rhinologists. One study utilized surface electromyography to document physical findings directly associated with the endoscopic sinus surgery procedure. However, relatively little work has been published on interventions to relieve task-related pain and body discomfort in rhinology. Summary Surgeon fatigue and bodily injury is a surprisingly frequent occurrence and is more likely to occur in procedures that are mentally challenging, prolonged, and require the surgeon to operate in a fixed position. Endoscopic sinus and skull base surgeons appear particularly susceptible to task-related physical discomfort, and incorporation of ergonomic principles should be a priority. Correspondence to Vijay R. Ramakrishnan, MD, Department of Otolaryngology, University of Colorado School of Medicine, 12631 E 17th Ave, B205, Aurora, CO 80045, USA. Tel: +1 303 724 1950; fax: +1 303 724 1961; e-mail: Vijay.ramakrishnan@ucdenver.edu Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Pain therapy for the elderly patient: is opioid-free an option?

Purpose of review Chronic noncancer pain is an increasing problem in elderly because of rising life expectancy together with an increase of potentially painful medical conditions. Concomitantly, adequate treatment of elderly is often limited by coexisting diseases and polypharmacy.This review summarizes the most important specifics presented by elderly patients and discusses the pharmacological and nonpharmacological options of pain management. Recent findings A comprehensive pain assessment is a prerequisite for effective pain management. However, this can be a major challenge in patients who are unable to communicate adequately, that is, in patients with dementia. A recently developed electronic tool assessing automated facial expression and clinical behavioral indicators may help to solve this problem. The discussion about benefits and harms of opioids in elderly goes on. Although some authors underline the lack of efficacy together with the potential problems, such as, abuse, others report a beneficial effect in terms of pain relief, functional activities and disability. In addition, opioids have become an important treatment option in patients with restless legs syndrome. Various topical treatment options (i.e. capsaicin patch) and nonpharmacological interventions have been proven to be beneficial in elderly. Summary Adequate pain management of elderly patients constitutes numerous pharmacological options including nonopioids, opioids, coanalgesics and topical agents. Due to age-related characteristics, all systemic analgesics have to be given very cautiously ('start low, go slow'). Whenever possible, treatment should be performed as a multimodal approach based on the biopsychosocial model of chronic pain. Correspondence to Shahnaz Christina Azad, MD, PhD, Department of Anesthesiology and Pain Medicine, Ludwig-Maximilians University Munich, Marchioninistr. 15, 81377 Munich, Germany. Tel: +49 89440074464; fax: +49 89440074469; e-mail: shahnaz.azad@med.uni-muenchen.de Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.

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Ergonomics in endoscopic sinus surgery

Purpose of review Awareness of ergonomics is growing into surgical specialties including otolaryngology. Most otolaryngologists experience occupational physical discomfort, and daily incorporation of standard ergonomic principles may alleviate some of this pain. Recent findings Further demonstration of surgery-related physical discomfort has been documented based on surveys of general otolaryngologists and subspecialty rhinologists. One study utilized surface electromyography to document physical findings directly associated with the endoscopic sinus surgery procedure. However, relatively little work has been published on interventions to relieve task-related pain and body discomfort in rhinology. Summary Surgeon fatigue and bodily injury is a surprisingly frequent occurrence and is more likely to occur in procedures that are mentally challenging, prolonged, and require the surgeon to operate in a fixed position. Endoscopic sinus and skull base surgeons appear particularly susceptible to task-related physical discomfort, and incorporation of ergonomic principles should be a priority. Correspondence to Vijay R. Ramakrishnan, MD, Department of Otolaryngology, University of Colorado School of Medicine, 12631 E 17th Ave, B205, Aurora, CO 80045, USA. Tel: +1 303 724 1950; fax: +1 303 724 1961; e-mail: Vijay.ramakrishnan@ucdenver.edu Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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European Surveillance System on Contact Allergies (ESSCA): contact allergies in relation to body sites in patients with allergic contact dermatitis

Background

Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on prevalence of contact allergies to the European baseline series; overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.

Objective

To determine prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD).

Methods

Analysis of data collected by ESSCA (www.essca‐dc.org) in consecutively patch tested patients, 2009‐2014, in 8 European countries. Cases were selected based on the presence of minimally one positive patch test to the baseline series, and a final diagnosis of ACD attributed to only one single body site.

Results

N=6,255 cases were analyzed. The head and hand were the most common single sites ACD was attributed to. Differences between countries were seen for several body sites. Nickel, fragrance mix I, cobalt and methylchloroisothiazolinone/methylisothiazolinone were the most frequent allergens reported for various body sites.

Conclusion

Distinct allergen patterns per body site were observed. However, contact allergies were probably not always relevant for the dermatitis that patients presented themselves with. Adding possibility to link positive patch test reactions to relevance, along with affected body sites should be a useful addition to data capturing systems.

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Christmas tree syndrome: How to prevent the allergy to festive trees - are you at risk?

CHRISTMAS trees and decorations could cause symptoms of the allergic Christmas tree syndrome. This is the health warning signs to look out for, as well as how to prevent the condition that causes runny noses and itchy skin. (Source: Daily Express - Health)

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CZI awards over $51 million to fight neurodegenerative disorders

(Chan Zuckerberg Initiative) Today, the Chan Zuckerberg Initiative (CZI) announced $64.25 million in funding and its selection of 17 early career investigators and nine collaborative science teams to launch the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields -- neuroscience, cell biology, biochemistry, immunology, and genomics -- along with computational biologists and physicians, to understand the underlying causes of neurodegenerative disorders. (Source: EurekAlert! - Medicine and Health)

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Christmas tree syndrome: How to prevent the allergy to festive trees - are you at risk?

CHRISTMAS trees and decorations could cause symptoms of the allergic Christmas tree syndrome. This is the health warning signs to look out for, as well as how to prevent the condition that causes runny noses and itchy skin. (Source: Daily Express - Health)

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CZI awards over $51 million to fight neurodegenerative disorders

(Chan Zuckerberg Initiative) Today, the Chan Zuckerberg Initiative (CZI) announced $64.25 million in funding and its selection of 17 early career investigators and nine collaborative science teams to launch the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields -- neuroscience, cell biology, biochemistry, immunology, and genomics -- along with computational biologists and physicians, to understand the underlying causes of neurodegenerative disorders. (Source: EurekAlert! - Medicine and Health)

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Christmas tree syndrome: How to prevent the allergy to festive trees - are you at risk?

CHRISTMAS trees and decorations could cause symptoms of the allergic Christmas tree syndrome. This is the health warning signs to look out for, as well as how to prevent the condition that causes runny noses and itchy skin. (Source: Daily Express - Health)

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CZI awards over $51 million to fight neurodegenerative disorders

(Chan Zuckerberg Initiative) Today, the Chan Zuckerberg Initiative (CZI) announced $64.25 million in funding and its selection of 17 early career investigators and nine collaborative science teams to launch the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields -- neuroscience, cell biology, biochemistry, immunology, and genomics -- along with computational biologists and physicians, to understand the underlying causes of neurodegenerative disorders. (Source: EurekAlert! - Medicine and Health)

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Christmas tree syndrome: How to prevent the allergy to festive trees - are you at risk?

CHRISTMAS trees and decorations could cause symptoms of the allergic Christmas tree syndrome. This is the health warning signs to look out for, as well as how to prevent the condition that causes runny noses and itchy skin. (Source: Daily Express - Health)

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CZI awards over $51 million to fight neurodegenerative disorders

(Chan Zuckerberg Initiative) Today, the Chan Zuckerberg Initiative (CZI) announced $64.25 million in funding and its selection of 17 early career investigators and nine collaborative science teams to launch the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields -- neuroscience, cell biology, biochemistry, immunology, and genomics -- along with computational biologists and physicians, to understand the underlying causes of neurodegenerative disorders. (Source: EurekAlert! - Medicine and Health)

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The North-Western Italian experience with anti IL-5 therapy amd comparison with regulatory trials

ConclusionsThe comparison of real-life patients' characteristics with regulatory trials, displayed several apparent discrepancies. The demographic and clinical aspects were similar in all groups, whereas other features (eosinophil count, pulmonary function FEV1%) differed. These data, for the first time, could represent a basis for a more accurate prescription of the drug. (Source: World Allergy Organization Journal)

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ALLERGY RELIEF (Cetirizine Hcl 10 Mg) Tablet [Genomma Labs USA, Inc]

Updated Date: Dec 5, 2018 EST (Source: DailyMed Drug Label Updates)

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The North-Western Italian experience with anti IL-5 therapy amd comparison with regulatory trials

ConclusionsThe comparison of real-life patients' characteristics with regulatory trials, displayed several apparent discrepancies. The demographic and clinical aspects were similar in all groups, whereas other features (eosinophil count, pulmonary function FEV1%) differed. These data, for the first time, could represent a basis for a more accurate prescription of the drug. (Source: World Allergy Organization Journal)

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ALLERGY RELIEF (Cetirizine Hcl 10 Mg) Tablet [Genomma Labs USA, Inc]

Updated Date: Dec 5, 2018 EST (Source: DailyMed Drug Label Updates)

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Day-case bilateral sagittal split osteotomy

In the UK, patients who have bilateral sagittal split osteotomy (BSSO) have generally been thought to require inpatient admission and an overnight hospital stay. However, since the introduction of national standards on day case surgery in the UK in 2011, patients at the Royal Gwent Hospital, Newport, have been treated as day cases, and have been pleased with the results. The aim of this paper was to show that these procedures conform to current national standards, and can be done successfully and safely. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Monte Carlo simulation of reasons for early failure of implants: effects of two risk factors

We have estimated the joint effects of two important risk factors on early failure of implants and then ranked all quoted risks by importance. We made a systematic search of published papers listed in PubMed, Web of Knowledge, Scopus, and Cochrane Central up to March 2018, and identified a total of 437 records. Eight studies met the inclusion criteria, in which seven significant risk factors for early failure were selected and used to build a conceptual simulation model. Selected risk factors were: "male sex", "smoking", "quality of bone", "short implants", "wide implants", "adjacent teeth", and "periodontitis". (Source: The British Journal of Oral and Maxillofacial Surgery)

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Day-case bilateral sagittal split osteotomy

In the UK, patients who have bilateral sagittal split osteotomy (BSSO) have generally been thought to require inpatient admission and an overnight hospital stay. However, since the introduction of national standards on day case surgery in the UK in 2011, patients at the Royal Gwent Hospital, Newport, have been treated as day cases, and have been pleased with the results. The aim of this paper was to show that these procedures conform to current national standards, and can be done successfully and safely. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Monte Carlo simulation of reasons for early failure of implants: effects of two risk factors

We have estimated the joint effects of two important risk factors on early failure of implants and then ranked all quoted risks by importance. We made a systematic search of published papers listed in PubMed, Web of Knowledge, Scopus, and Cochrane Central up to March 2018, and identified a total of 437 records. Eight studies met the inclusion criteria, in which seven significant risk factors for early failure were selected and used to build a conceptual simulation model. Selected risk factors were: "male sex", "smoking", "quality of bone", "short implants", "wide implants", "adjacent teeth", and "periodontitis". (Source: The British Journal of Oral and Maxillofacial Surgery)

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Lack of Sphenoid Pneumatization Does Not Affect Endoscopic Endonasal Pediatric Skull Base Surgery Outcomes

Objectives/Hypothesis

Currently, due to the rarity of pathology, there are limited data surrounding outcomes of pediatric skull base surgery. Traditionally, surgeons have proceeded with caution when electing endonasal endoscopic transsellar/transplanum approaches to the skull base in pediatric patients due to poor sphenoid pneumatization. In this study, we review outcomes of endoscopic pediatric skull base surgery based on sphenoid pneumatization patterns.

Study Design

Retrospective chart review.

Methods

A review of all cases of pediatric (age < 18 years) craniopharyngioma managed via an endoscopic endonasal approach at a tertiary academic medical center.

Results

A total of 27 patients were included in the analysis. The median age was 8 years. Nineteen (70%) patients were male. Presellar, sellar/postsellar, and conchal sphenoid pneumatizations were found in 6, 11, and 10 patients, respectively. There was no significant association between sphenoid pneumatization pattern and extent of resection (gross vs. subtotal, P = .414), postoperative cerebrospinal fluid (CSF) leak (P = .450), intraoperative estimated blood loss (P = .098), total operative time (P = .540), and length of stay (P = .336). On multivariate analysis, after accounting for age, sex, preoperative cranial nerve involvement, and cavernous sinus invasion, there remained no significant association between sphenoid pneumatization pattern and extent of resection (P = .999) and postoperative CSF leak (P = .959).

Conclusions

Sphenoid pneumatization pattern does not appear to affect outcomes in endoscopic skull base surgery in the pediatric population. Importantly, lack of sphenoid pneumatization does not impede gross total resection or increase complications. Thorough knowledge of the anatomy during the endoscopic approach is critical to optimize outcomes.

Level of Evidence

4 Laryngoscope, 2018

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Lack of Sphenoid Pneumatization Does Not Affect Endoscopic Endonasal Pediatric Skull Base Surgery Outcomes

Objectives/Hypothesis

Currently, due to the rarity of pathology, there are limited data surrounding outcomes of pediatric skull base surgery. Traditionally, surgeons have proceeded with caution when electing endonasal endoscopic transsellar/transplanum approaches to the skull base in pediatric patients due to poor sphenoid pneumatization. In this study, we review outcomes of endoscopic pediatric skull base surgery based on sphenoid pneumatization patterns.

Study Design

Retrospective chart review.

Methods

A review of all cases of pediatric (age < 18 years) craniopharyngioma managed via an endoscopic endonasal approach at a tertiary academic medical center.

Results

A total of 27 patients were included in the analysis. The median age was 8 years. Nineteen (70%) patients were male. Presellar, sellar/postsellar, and conchal sphenoid pneumatizations were found in 6, 11, and 10 patients, respectively. There was no significant association between sphenoid pneumatization pattern and extent of resection (gross vs. subtotal, P = .414), postoperative cerebrospinal fluid (CSF) leak (P = .450), intraoperative estimated blood loss (P = .098), total operative time (P = .540), and length of stay (P = .336). On multivariate analysis, after accounting for age, sex, preoperative cranial nerve involvement, and cavernous sinus invasion, there remained no significant association between sphenoid pneumatization pattern and extent of resection (P = .999) and postoperative CSF leak (P = .959).

Conclusions

Sphenoid pneumatization pattern does not appear to affect outcomes in endoscopic skull base surgery in the pediatric population. Importantly, lack of sphenoid pneumatization does not impede gross total resection or increase complications. Thorough knowledge of the anatomy during the endoscopic approach is critical to optimize outcomes.

Level of Evidence

4 Laryngoscope, 2018

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Chondrosarcoma of the jaw bones: a review of 224 cases reported to date and an analysis of prognostic factors

The objective was to integrate the available published data on chondrosarcoma (CHS) of the jaw bones into a comprehensive analysis of its clinical and histological features, treatment, and prognostic factors. An electronic search was undertaken in October 2017. To be eligible, the publication had to provide sufficient clinical/histological data to confirm the diagnosis. One hundred and ten publications (224 cases of CHS) were identified and included. There was a slightly higher prevalence of CHS in males than in females. (Source: International Journal of Oral and Maxillofacial Surgery)

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Chondrosarcoma of the jaw bones: a review of 224 cases reported to date and an analysis of prognostic factors

The objective was to integrate the available published data on chondrosarcoma (CHS) of the jaw bones into a comprehensive analysis of its clinical and histological features, treatment, and prognostic factors. An electronic search was undertaken in October 2017. To be eligible, the publication had to provide sufficient clinical/histological data to confirm the diagnosis. One hundred and ten publications (224 cases of CHS) were identified and included. There was a slightly higher prevalence of CHS in males than in females. (Source: International Journal of Oral and Maxillofacial Surgery)

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New Cancer Therapies: Implications for the Perioperative Period

Abstract

Purpose of Review

Cancer is on the rise. Standing on verge of exciting discoveries, research is being translated into therapies that are being widely administered to patients. Providing a hope for cure, where none existed before. This new body of knowledge has come from a better understanding of cancer genetics, molecular and sub molecular behavior, and understanding of cancer-generated cellular environments. These have led to development of immunotherapy and its many sub-genres, improvement and introduction of new radiation technologies, and decreasing toxicities of existing chemotherapies.

Recent Findings

The purpose of this review is to have a summary look at this huge landscape of cancer therapy. Specially looking at toxicities that an anesthesiologist should be familiar with while providing perioperative care for these patients, complications like tumor lysis syndrome, cytokine release syndromes, Kounis syndrome, myocarditis, encephalopathies, and pituitary failure need to be kept in mind.

Summary

One should be knowledgeable about these therapies and approach these patients with a high index of suspicion. Anesthesiologists will need to refine preoperative assessment with appropriate testing and intraoperative and postoperative management in collaboration with oncologists, while involving the expertise of internists, cardiologist, and endocrinologists in helping assess and manage these patients in the perioperative period.

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Causes of variability in latent phenotypes of childhood wheeze

Latent class analysis (LCA) has been used extensively to identify (latent) phenotypes of childhood wheezing. However, the number and trajectory of discovered phenotypes differed substantially between studies. (Source: Journal of Allergy and Clinical Immunology)

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A computerized decision support tool to implement asthma guidelines for children and adolescents

The acceptance and performance of a guideline-based, computerized decision support tool to assess and score asthma control and then provide appropriate treatment step for inner-city children and adolescents with poorly controlled asthma was excellent. (Source: Journal of Allergy and Clinical Immunology)

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A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for ACO in low- and middle- income countries

(Source: Journal of Allergy and Clinical Immunology)

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Causes of variability in latent phenotypes of childhood wheeze

Latent class analysis (LCA) has been used extensively to identify (latent) phenotypes of childhood wheezing. However, the number and trajectory of discovered phenotypes differed substantially between studies. (Source: Journal of Allergy and Clinical Immunology)

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A computerized decision support tool to implement asthma guidelines for children and adolescents

The acceptance and performance of a guideline-based, computerized decision support tool to assess and score asthma control and then provide appropriate treatment step for inner-city children and adolescents with poorly controlled asthma was excellent. (Source: Journal of Allergy and Clinical Immunology)

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Role of Der p 1-specific B cells in immune tolerance during 2-year house dust mite-specific immunotherapy

Allergen-specific immunotherapy induces IgG4-producing allergen-specific B cells, plasmablasts, and IL-10- and/or IL-1RA-producing Breg cells which correlate with clinical response during the treatment. (Source: Journal of Allergy and Clinical Immunology)

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A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for ACO in low- and middle- income countries

(Source: Journal of Allergy and Clinical Immunology)

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Miscarriage History, ART May Up Offspring Asthma Risk

(MedPage Today) -- Fertility issues pop up in registry study (Source: MedPage Today Allergy)

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Miscarriage History, ART May Up Offspring Asthma Risk

(MedPage Today) -- Fertility issues pop up in registry study (Source: MedPage Today Allergy)

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Miscarriage History, ART May Up Offspring Asthma Risk

(MedPage Today) -- Fertility issues pop up in registry study (Source: MedPage Today Allergy)

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Miscarriage History, ART May Up Offspring Asthma Risk

(MedPage Today) -- Fertility issues pop up in registry study (Source: MedPage Today Allergy)

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Miscarriage History, ART May Up Offspring Asthma Risk

(MedPage Today) -- Fertility issues pop up in registry study (Source: MedPage Today Allergy)

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Miscarriage History, ART May Up Offspring Asthma Risk

(MedPage Today) -- Fertility issues pop up in registry study (Source: MedPage Today Allergy)

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A computerized decision support tool to implement asthma guidelines for children and adolescents

The acceptance and performance of a guideline-based, computerized decision support tool to assess and score asthma control and then provide appropriate treatment step for inner-city children and adolescents with poorly controlled asthma was excellent. (Source: Journal of Allergy and Clinical Immunology)

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Arrhythmia in thiamine responsive megaloblastic anemia syndrome.

We present cardiac features of five patients with TRMAS. Five patients had macrocytic anemia, diabetes mellitus, and sensorineural deafness. Two siblings had also optic atrophy. SLC19A2 gene mutation was shown in all patients. Two patients developed supraventricular tachycardia during an episode of diabetic ketoacidosis. Five patients had absent P waves on baseline electrocardiography, and one patient had additional low QRS voltage. None of the patients had structural heart disease. Discontinuation of thiamine treatment appears to trigger supraventricular tachycardia episodes at puberty. PMID: 30511554 [PubMed - in process] (Source: The Turkish Journal of Pediatrics)

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Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

Anna C. Belkina, Alina Starchenko, Katherine A. Drake, Elizabeth A. Proctor, Riley M. F. Pihl, Alex Olson, Douglas A. Lauffenburger, Nina Lin, Jennifer E. Snyder-Cappione (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QBoEJz

The North-Western Italian experience with anti IL-5 therapy amd comparison with regulatory trials

ConclusionsThe comparison of real-life patients' characteristics with regulatory trials, displayed several apparent discrepancies. The demographic and clinical aspects were similar in all groups, whereas other features (eosinophil count, pulmonary function FEV1%) differed. These data, for the first time, could represent a basis for a more accurate prescription of the drug. (Source: World Allergy Organization Journal)

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Corrigendum to “Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway” [J. Neuroimmunol. 299 (2016) 164–171]

After publication of this article, the authors became aware of a typographical error in Fig. 2A. The immunofluorescence staining image of VAChT and AChE in the sham group in Fig. 2A was inadvertently a duplicate of the BCAS+RAD001 group. The authors apologize for this oversight. All the original data and analyses in the paper have now been thoroughly checked, and the Fig. 2A has been replaced now with the right image based on the original data. We can verify that no data from the analytic results were affected. (Source: Journal of Neuroimmunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QEEEKS

Causes of variability in latent phenotypes of childhood wheeze

Latent class analysis (LCA) has been used extensively to identify (latent) phenotypes of childhood wheezing. However, the number and trajectory of discovered phenotypes differed substantially between studies. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E1q1uC

Role of Der p 1-specific B cells in immune tolerance during 2-year house dust mite-specific immunotherapy

Allergen-specific immunotherapy induces IgG4-producing allergen-specific B cells, plasmablasts, and IL-10- and/or IL-1RA-producing Breg cells which correlate with clinical response during the treatment. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E5qig9

A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for ACO in low- and middle- income countries

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QzaTeG

Hyperemia Analysis Software for Assessment of Conjunctival Hyperemia Severity.

CONCLUSION: The percent coverage from our hyperemia analysis software reflects the clinical grading score, suggesting that our software can be used to obtain a detailed analysis of conjunctival hyperemia. PMID: 30512976 [PubMed - as supplied by publisher] (Source: Current Eye Research)

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Der Mini-Audio-Test (MAT) – eine Screeningmethode auf Schwerhörigkeit für Haus- und Fachärzte

Laryngo-Rhino-Otol
DOI: 10.1055/a-0805-5741

Hintergrund In Deutschland leiden etwa 15 Millionen Menschen an einer Schwerhörigkeit (SH), doch nur 16 % tragen Hörgeräte. Diese Unterversorgung kann für die Betroffenen zu schwerwiegenden Folgen (soziale Isolation, Depression, Förderung einer Demenz etc.) führen. Ein frühzeitiges und flächendeckendes Hörscreening ab dem 50. Lebensjahr kann dies verbessern. In dieser Studie wurde der Mini-Audio-Test (MAT), ein sechs Fragen zum subjektiven Hörverlust (HV) umfassender Test mit dreistufiger Antwortskala, an einem Normalkollektiv überprüft (Sensitivität (Se), Spezifität (Sp), positiver prädiktiver Wert (PPW)). Methode Es wurden 943 Patienten (älter als 50 Jahre) ohne bekannte Ohrenerkrankungen mittels MAT befragt, zum Vergleich die Hörschwellen tonaudiometrisch ermittelt und die Se, Sp und der PPW zur Detektion eines relevanten HV durch den MAT für die Altersklassen < 60 Jahre (AG1) und ≥ 60 Jahre (AG2) mittels binomialer Proportionen ermittelt. Ergebnisse Die Se lag für AG1 bei 0,66, die Sp bei 0,61, der PW bei 0,60, für die AG2 lag die Se bei 0,47, die Sp bei 0,80, der PPW bei 0,89. Schlussfolgerung Entsprechend der vorliegenden Ergebnisse wird der Einsatz des MAT als Screeningmethode für Nicht-HNO-Ärzte zur Detektion von schwerhörenden Patienten ab dem 50. Lebensjahr vorgeschlagen. Hierdurch ließen sich auch schwerwiegende Begleiterkrankungen wie Minderung der kognitiven Leistungsfähigkeit, Sturzrisiko, Depression und Demenz positiv beeinflussen.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Arrhythmia in thiamine responsive megaloblastic anemia syndrome.

We present cardiac features of five patients with TRMAS. Five patients had macrocytic anemia, diabetes mellitus, and sensorineural deafness. Two siblings had also optic atrophy. SLC19A2 gene mutation was shown in all patients. Two patients developed supraventricular tachycardia during an episode of diabetic ketoacidosis. Five patients had absent P waves on baseline electrocardiography, and one patient had additional low QRS voltage. None of the patients had structural heart disease. Discontinuation of thiamine treatment appears to trigger supraventricular tachycardia episodes at puberty. PMID: 30511554 [PubMed - in process] (Source: The Turkish Journal of Pediatrics)

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Transforming and transitioning —the past and the future

. (Source: International Journal of Audiology)

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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature

Fulan Shan, Youming Long, Wei Qiu (Source: Frontiers in Immunology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E1qdKm

Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

Anna C. Belkina, Alina Starchenko, Katherine A. Drake, Elizabeth A. Proctor, Riley M. F. Pihl, Alex Olson, Douglas A. Lauffenburger, Nina Lin, Jennifer E. Snyder-Cappione (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QBoEJz

Corrigendum to “Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway” [J. Neuroimmunol. 299 (2016) 164–171]

After publication of this article, the authors became aware of a typographical error in Fig. 2A. The immunofluorescence staining image of VAChT and AChE in the sham group in Fig. 2A was inadvertently a duplicate of the BCAS+RAD001 group. The authors apologize for this oversight. All the original data and analyses in the paper have now been thoroughly checked, and the Fig. 2A has been replaced now with the right image based on the original data. We can verify that no data from the analytic results were affected. (Source: Journal of Neuroimmunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QEEEKS

Causes of variability in latent phenotypes of childhood wheeze

Latent class analysis (LCA) has been used extensively to identify (latent) phenotypes of childhood wheezing. However, the number and trajectory of discovered phenotypes differed substantially between studies. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E1q1uC

A computerized decision support tool to implement asthma guidelines for children and adolescents

The acceptance and performance of a guideline-based, computerized decision support tool to assess and score asthma control and then provide appropriate treatment step for inner-city children and adolescents with poorly controlled asthma was excellent. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QDLZuj

Role of Der p 1-specific B cells in immune tolerance during 2-year house dust mite-specific immunotherapy

Allergen-specific immunotherapy induces IgG4-producing allergen-specific B cells, plasmablasts, and IL-10- and/or IL-1RA-producing Breg cells which correlate with clinical response during the treatment. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E5qig9

A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for ACO in low- and middle- income countries

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QzaTeG

Hyperemia Analysis Software for Assessment of Conjunctival Hyperemia Severity.

CONCLUSION: The percent coverage from our hyperemia analysis software reflects the clinical grading score, suggesting that our software can be used to obtain a detailed analysis of conjunctival hyperemia. PMID: 30512976 [PubMed - as supplied by publisher] (Source: Current Eye Research)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E3zXDI

Der Mini-Audio-Test (MAT) – eine Screeningmethode auf Schwerhörigkeit für Haus- und Fachärzte

Laryngo-Rhino-Otol
DOI: 10.1055/a-0805-5741

Hintergrund In Deutschland leiden etwa 15 Millionen Menschen an einer Schwerhörigkeit (SH), doch nur 16 % tragen Hörgeräte. Diese Unterversorgung kann für die Betroffenen zu schwerwiegenden Folgen (soziale Isolation, Depression, Förderung einer Demenz etc.) führen. Ein frühzeitiges und flächendeckendes Hörscreening ab dem 50. Lebensjahr kann dies verbessern. In dieser Studie wurde der Mini-Audio-Test (MAT), ein sechs Fragen zum subjektiven Hörverlust (HV) umfassender Test mit dreistufiger Antwortskala, an einem Normalkollektiv überprüft (Sensitivität (Se), Spezifität (Sp), positiver prädiktiver Wert (PPW)). Methode Es wurden 943 Patienten (älter als 50 Jahre) ohne bekannte Ohrenerkrankungen mittels MAT befragt, zum Vergleich die Hörschwellen tonaudiometrisch ermittelt und die Se, Sp und der PPW zur Detektion eines relevanten HV durch den MAT für die Altersklassen < 60 Jahre (AG1) und ≥ 60 Jahre (AG2) mittels binomialer Proportionen ermittelt. Ergebnisse Die Se lag für AG1 bei 0,66, die Sp bei 0,61, der PW bei 0,60, für die AG2 lag die Se bei 0,47, die Sp bei 0,80, der PPW bei 0,89. Schlussfolgerung Entsprechend der vorliegenden Ergebnisse wird der Einsatz des MAT als Screeningmethode für Nicht-HNO-Ärzte zur Detektion von schwerhörenden Patienten ab dem 50. Lebensjahr vorgeschlagen. Hierdurch ließen sich auch schwerwiegende Begleiterkrankungen wie Minderung der kognitiven Leistungsfähigkeit, Sturzrisiko, Depression und Demenz positiv beeinflussen.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rm7uBw

The North-Western Italian experience with anti IL-5 therapy amd comparison with regulatory trials

Abstract

Background

The severe forms of asthma represent a major burden, because of severity of symptoms, costs and impact on everyday life. Recently, Mepolizumab (MEP) was approved and marketed for the treatment of hypereosinophilic severe asthma. This anti-IL-5 monoclonal antibody reduced exacerbation rates and oral corticosteroid (OCS) use in well selected patients. The aim of this study was to evaluate the characteristics of patients receiving MEP in a real-life setting. Thus, we describe a retrospective analysis of patients treated with MEP in six centres in North Western Italy, including those who participated in the main regulatory trials.

Methods

The baseline data, before prescription, from six North Western Italy severe asthma clinics, between June 1st 2017 and December 31st 2017, were evaluated. The collected real-life data were then compared with those of SIRUS, MENSA, DREAM and MUSCA trials.

Results

Sixty-five patients were included (45% female; mean age 56 years; age range 19–84). Main observed differences with regulatory trials could be observed in eosinophils blood count at baseline, where the mean of our real-life patients (653 cells/μL) was overall higher than the one of all trials (240 cells/μL, 296 cells/μL, 253 cells/μL; p <  0.0001). The incidence of polyposis was also significantly higher in our sample (72% vs. 24%, 49%, 10%, 19%; p <  0.0001). The daily average dose of OCS was lower in our real-life patients (9 mg), if compared with SIRIUS (13.7 mg), MENSA (13.2) and MUSCA (13), and similar to the data published in DREAM (10.8).

Conclusions

The comparison of real-life patients' characteristics with regulatory trials, displayed several apparent discrepancies. The demographic and clinical aspects were similar in all groups, whereas other features (eosinophil count, pulmonary function FEV1%) differed. These data, for the first time, could represent a basis for a more accurate prescription of the drug.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QBnUUZ

The North-Western Italian experience with anti IL-5 therapy amd comparison with regulatory trials

Abstract

Background

The severe forms of asthma represent a major burden, because of severity of symptoms, costs and impact on everyday life. Recently, Mepolizumab (MEP) was approved and marketed for the treatment of hypereosinophilic severe asthma. This anti-IL-5 monoclonal antibody reduced exacerbation rates and oral corticosteroid (OCS) use in well selected patients. The aim of this study was to evaluate the characteristics of patients receiving MEP in a real-life setting. Thus, we describe a retrospective analysis of patients treated with MEP in six centres in North Western Italy, including those who participated in the main regulatory trials.

Methods

The baseline data, before prescription, from six North Western Italy severe asthma clinics, between June 1st 2017 and December 31st 2017, were evaluated. The collected real-life data were then compared with those of SIRUS, MENSA, DREAM and MUSCA trials.

Results

Sixty-five patients were included (45% female; mean age 56 years; age range 19–84). Main observed differences with regulatory trials could be observed in eosinophils blood count at baseline, where the mean of our real-life patients (653 cells/μL) was overall higher than the one of all trials (240 cells/μL, 296 cells/μL, 253 cells/μL; p <  0.0001). The incidence of polyposis was also significantly higher in our sample (72% vs. 24%, 49%, 10%, 19%; p <  0.0001). The daily average dose of OCS was lower in our real-life patients (9 mg), if compared with SIRIUS (13.7 mg), MENSA (13.2) and MUSCA (13), and similar to the data published in DREAM (10.8).

Conclusions

The comparison of real-life patients' characteristics with regulatory trials, displayed several apparent discrepancies. The demographic and clinical aspects were similar in all groups, whereas other features (eosinophil count, pulmonary function FEV1%) differed. These data, for the first time, could represent a basis for a more accurate prescription of the drug.

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Immunotherapy extends the life of head and neck cancer patients

Source: Pharmatimes.com Date: 12/3/18 Author: Anna Smith A new immunotherapy can greatly extend the lives of a proportion of people with […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2L14gN2

Immunotherapy extends the life of head and neck cancer patients

Source: Pharmatimes.com Date: 12/3/18 Author: Anna Smith A new immunotherapy can greatly extend the lives of a proportion of people with […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2L14gN2

Immunotherapy extends the life of head and neck cancer patients

Source: Pharmatimes.com Date: 12/3/18 Author: Anna Smith A new immunotherapy can greatly extend the lives of a proportion of people with […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2L14gN2

Maxillary sinus floor augmentation using low-crystalline carbonate apatite granules with simultaneous implant installation: First-in-human clinical trial

Carbonate apatite (CO3Ap), an inorganic component of human bone, can be fabricated in chemically pure form from calcium carbonate block via dissolution-precipitation. A first-in-human clinical trial was conducted in which low-crystalline CO3Ap granules were evaluated for safety and efficacy in sinus floor augmentation and simultaneous implant installation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UhxGKN

Morphological evaluation of the nasopalatine canal in patients with different facial profiles and ages

To evaluate the influence of the facial profile and age on the morphology of the nasopalatine canal.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AZqlqm

Immunotherapy extends the life of head and neck cancer patients

Source: Pharmatimes.com Date: 12/3/18 Author: Anna Smith A new immunotherapy can greatly extend the lives of a proportion of people with […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2L14gN2

Maxillary sinus floor augmentation using low-crystalline carbonate apatite granules with simultaneous implant installation: First-in-human clinical trial

Carbonate apatite (CO3Ap), an inorganic component of human bone, can be fabricated in chemically pure form from calcium carbonate block via dissolution-precipitation. A first-in-human clinical trial was conducted in which low-crystalline CO3Ap granules were evaluated for safety and efficacy in sinus floor augmentation and simultaneous implant installation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UhxGKN

Morphological evaluation of the nasopalatine canal in patients with different facial profiles and ages

To evaluate the influence of the facial profile and age on the morphology of the nasopalatine canal.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AZqlqm

Maxillary sinus floor augmentation using low-crystalline carbonate apatite granules with simultaneous implant installation: First-in-human clinical trial

Carbonate apatite (CO3Ap), an inorganic component of human bone, can be fabricated in chemically pure form from calcium carbonate block via dissolution-precipitation. A first-in-human clinical trial was conducted in which low-crystalline CO3Ap granules were evaluated for safety and efficacy in sinus floor augmentation and simultaneous implant installation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UhxGKN

Morphological evaluation of the nasopalatine canal in patients with different facial profiles and ages

To evaluate the influence of the facial profile and age on the morphology of the nasopalatine canal.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AZqlqm

Maxillary sinus floor augmentation using low-crystalline carbonate apatite granules with simultaneous implant installation: First-in-human clinical trial

Carbonate apatite (CO3Ap), an inorganic component of human bone, can be fabricated in chemically pure form from calcium carbonate block via dissolution-precipitation. A first-in-human clinical trial was conducted in which low-crystalline CO3Ap granules were evaluated for safety and efficacy in sinus floor augmentation and simultaneous implant installation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UhxGKN

Risk factors and distribution features of level IB lymph nodes metastasis in nasopharyngeal carcinoma

The objective of this study is to investigate the risk factors and distribution features for level IB metastasis in nasopharyngeal carcinoma (NPC) and provide clinical evidence for defining the indications and clinical target volume (CTV) of prophylactic level IB irradiation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SwcZJj

Risk factors and distribution features of level IB lymph nodes metastasis in nasopharyngeal carcinoma

The objective of this study is to investigate the risk factors and distribution features for level IB metastasis in nasopharyngeal carcinoma (NPC) and provide clinical evidence for defining the indications and clinical target volume (CTV) of prophylactic level IB irradiation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SwcZJj

A computerized decision support tool to implement asthma guidelines for children and adolescents

The acceptance and performance of a guideline-based, computerized decision support tool to assess and score asthma control and then provide appropriate treatment step for inner-city children and adolescents with poorly controlled asthma was excellent.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EjuwBA

A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for ACO in low- and middle- income countries

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Efvw9Y

Role of Der p 1-specific B cells in immune tolerance during 2-year house dust mite-specific immunotherapy

Allergen-specific immunotherapy induces IgG4-producing allergen-specific B cells, plasmablasts, and IL-10- and/or IL-1RA-producing Breg cells which correlate with clinical response during the treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sx7uua

Causes of variability in latent phenotypes of childhood wheeze

Latent class analysis (LCA) has been used extensively to identify (latent) phenotypes of childhood wheezing. However, the number and trajectory of discovered phenotypes differed substantially between studies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sx7tGC

Newly identified T cells could play a role in cancer and other diseases

FINDINGSResearchers from the UCLA Jonsson Comprehensive Cancer Center and the La Jolla Institute for Immunology have identified a new type of T cell called a phospholipid-reactive T cell that is able to recognize phospholipids, the molecules that help form cells ' outer membranes.The scientists also discovered that phospholipids compete with glycolipids, another type of molecule that helps form cells ' outer membranes, in a way that prevents glycolipids from readily reaching the surface of a cell.BACKGROUNDCell membranes are primarily made up of two types of lipids — phospholipids and glycolipids. Inside cells, these lipids bind to a molecule called CD1d that transports them to the surface. Once there, phospholipids stimulate phospholipid-reactive T cells, and glycolipids stimulate a...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Eeoy4Z

CZI awards over $64 million to fight neurodegenerative disorders

(Chan Zuckerberg Initiative) Today, the Chan Zuckerberg Initiative (CZI) announced $64.25 million in funding and its selection of 17 early career investigators and nine collaborative science teams to launch the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields -- neuroscience, cell biology, biochemistry, immunology, and genomics -- along with computational biologists and physicians, to understand the underlying causes of neurodegenerative disorders. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SqYjey

A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for ACO in low- and middle- income countries

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Efvw9Y

Role of Der p 1-specific B cells in immune tolerance during 2-year house dust mite-specific immunotherapy

Allergen-specific immunotherapy induces IgG4-producing allergen-specific B cells, plasmablasts, and IL-10- and/or IL-1RA-producing Breg cells which correlate with clinical response during the treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sx7uua

A computerized decision support tool to implement asthma guidelines for children and adolescents

The acceptance and performance of a guideline-based, computerized decision support tool to assess and score asthma control and then provide appropriate treatment step for inner-city children and adolescents with poorly controlled asthma was excellent.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EjuwBA

Causes of variability in latent phenotypes of childhood wheeze

Latent class analysis (LCA) has been used extensively to identify (latent) phenotypes of childhood wheezing. However, the number and trajectory of discovered phenotypes differed substantially between studies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sx7tGC

Newly identified T cells could play a role in cancer and other diseases

FINDINGSResearchers from the UCLA Jonsson Comprehensive Cancer Center and the La Jolla Institute for Immunology have identified a new type of T cell called a phospholipid-reactive T cell that is able to recognize phospholipids, the molecules that help form cells ' outer membranes.The scientists also discovered that phospholipids compete with glycolipids, another type of molecule that helps form cells ' outer membranes, in a way that prevents glycolipids from readily reaching the surface of a cell.BACKGROUNDCell membranes are primarily made up of two types of lipids — phospholipids and glycolipids. Inside cells, these lipids bind to a molecule called CD1d that transports them to the surface. Once there, phospholipids stimulate phospholipid-reactive T cells, and glycolipids stimulate a...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Eeoy4Z

CZI awards over $64 million to fight neurodegenerative disorders

(Chan Zuckerberg Initiative) Today, the Chan Zuckerberg Initiative (CZI) announced $64.25 million in funding and its selection of 17 early career investigators and nine collaborative science teams to launch the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields -- neuroscience, cell biology, biochemistry, immunology, and genomics -- along with computational biologists and physicians, to understand the underlying causes of neurodegenerative disorders. (Source: EurekAlert! - Medicine and Health)

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Chondrosarcoma of the jaw bones: a review of 224 cases reported to date and an analysis of prognostic factors

The objective was to integrate the available published data on chondrosarcoma (CHS) of the jaw bones into a comprehensive analysis of its clinical and histological features, treatment, and prognostic factors. An electronic search was undertaken in October 2017. To be eligible, the publication had to provide sufficient clinical/histological data to confirm the diagnosis. One hundred and ten publications (224 cases of CHS) were identified and included. There was a slightly higher prevalence of CHS in males than in females.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2G3mtdP

Chondrosarcoma of the jaw bones: a review of 224 cases reported to date and an analysis of prognostic factors

The objective was to integrate the available published data on chondrosarcoma (CHS) of the jaw bones into a comprehensive analysis of its clinical and histological features, treatment, and prognostic factors. An electronic search was undertaken in October 2017. To be eligible, the publication had to provide sufficient clinical/histological data to confirm the diagnosis. One hundred and ten publications (224 cases of CHS) were identified and included. There was a slightly higher prevalence of CHS in males than in females.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2G3mtdP

Monte Carlo simulation of reasons for early failure of implants: effects of two risk factors

We have estimated the joint effects of two important risk factors on early failure of implants and then ranked all quoted risks by importance. We made a systematic search of published papers listed in PubMed, Web of Knowledge, Scopus, and Cochrane Central up to March 2018, and identified a total of 437 records. Eight studies met the inclusion criteria, in which seven significant risk factors for early failure were selected and used to build a conceptual simulation model. Selected risk factors were: "male sex", "smoking", "quality of bone", "short implants", "wide implants", "adjacent teeth", and "periodontitis".

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Day-case bilateral sagittal split osteotomy

In the UK, patients who have bilateral sagittal split osteotomy (BSSO) have generally been thought to require inpatient admission and an overnight hospital stay. However, since the introduction of national standards on day case surgery in the UK in 2011, patients at the Royal Gwent Hospital, Newport, have been treated as day cases, and have been pleased with the results. The aim of this paper was to show that these procedures conform to current national standards, and can be done successfully and safely.

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Monte Carlo simulation of reasons for early failure of implants: effects of two risk factors

We have estimated the joint effects of two important risk factors on early failure of implants and then ranked all quoted risks by importance. We made a systematic search of published papers listed in PubMed, Web of Knowledge, Scopus, and Cochrane Central up to March 2018, and identified a total of 437 records. Eight studies met the inclusion criteria, in which seven significant risk factors for early failure were selected and used to build a conceptual simulation model. Selected risk factors were: "male sex", "smoking", "quality of bone", "short implants", "wide implants", "adjacent teeth", and "periodontitis".

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Day-case bilateral sagittal split osteotomy

In the UK, patients who have bilateral sagittal split osteotomy (BSSO) have generally been thought to require inpatient admission and an overnight hospital stay. However, since the introduction of national standards on day case surgery in the UK in 2011, patients at the Royal Gwent Hospital, Newport, have been treated as day cases, and have been pleased with the results. The aim of this paper was to show that these procedures conform to current national standards, and can be done successfully and safely.

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The effects of common yarrow (Achillea millefolium Linnaeus), cinnamon (Cinnamomum zeylanicum Blume) and rosemary (Rosemarinus officinalis Linnaeus) hydrosols on the some immunological and hematological parameters of common carp (Cyprinus carpio L., 1758).

In this study, the effects of some plant hydrosols (distilled plant waters) based upon some hematological parameters and Nitroblue Tetrazolium (NBT) activities in the common carp (Cyprinus carpio Linnaeus, 1758) infected with Yersinia ruckeri were investigated. In the trial, it was utilized totally 200 common carps with 54.3±6.7 g mean live weight and 15.7±1.8 cm mean total lenght. The 10% rate of the common yarrow (Achillea millefolium Linnaeus) hydrosol; 0.5% rate of the cinnamon (Cinnamomum zeylanicum Blume) hydrosol; and 5% rate of the rosemary (Rosemarinus officinalis Linnaeus) hydrosol were applied to fish as a bath treatment. The erythrocyte (RBC), leukocyte count (WBC), hematocrit value (HCT), haemoglobin amount (Hg), mean corpuscular volume (MCV), mean corpuscular haemoglobin (M...

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STAT6 variants and non-atopic asthma in Pakistani population.

Authors: Riaz A, Ahsan Riaz M, Khan L, Shareef Masoud M, Hussain G, Iqbal M, Qasim M Abstract Asthma a chronic airway inflammatory disease mainly characterized by airways obstruction. Airway hyper responsiveness particularly in eosinophils and inflammatory mediators affect the bronchial mucosa. Genetic association studies show the association of single nucleotide polymorphisms (SNPs) in the STAT6 gene with asthma risk. Role of Signal transducer and activator of transcription 6 (STAT6) is acute for T-helper 2 (Th2) mediated responses during allergic airway diseases. Objective was to investigate whether the two single nucleotide polymorphism (rs4559 and rs324011) in STAT6 gene are associated with non-atopic asthma risk in Pakistani population. One hundred (100) asthma patients with a...

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Immunological effects of the intraparenchymal administration of allogeneic and autologous adipose-derived mesenchymal stem cells after the acute phase of middle cerebral artery occlusion in rats

This study was aimed at analyzi... (Source: Journal of Translational Medicine)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Eg7xra

Recurrence of allergic bronchopulmonary aspergillosis after adjunctive surgery for aspergilloma: a case report with long-term follow-up

Coexistence of aspergilloma and allergic bronchopulmonary aspergillosis (ABPA) has rarely been reported. Although the treatment for ABPA includes administration of corticosteroids and antifungal agents, little... (Source: BMC Pulmonary Medicine)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sx1SjA

Newly identified T cells could play a role in cancer and other diseases

FINDINGSResearchers from the UCLA Jonsson Comprehensive Cancer Center and the La Jolla Institute for Immunology have identified a new type of T cell called a phospholipid-reactive T cell that is able to recognize phospholipids, the molecules that help form cells ' outer membranes.The scientists also discovered that phospholipids compete with glycolipids, another type of molecule that helps form cells ' outer membranes, in a way that prevents glycolipids from readily reaching the surface of a cell.BACKGROUNDCell membranes are primarily made up of two types of lipids — phospholipids and glycolipids. Inside cells, these lipids bind to a molecule called CD1d that transports them to the surface. Once there, phospholipids stimulate phospholipid-reactive T cells, and glycolipids stimulate a...

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CZI awards over $64 million to fight neurodegenerative disorders

(Chan Zuckerberg Initiative) Today, the Chan Zuckerberg Initiative (CZI) announced $64.25 million in funding and its selection of 17 early career investigators and nine collaborative science teams to launch the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields -- neuroscience, cell biology, biochemistry, immunology, and genomics -- along with computational biologists and physicians, to understand the underlying causes of neurodegenerative disorders. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SqYjey

The effects of common yarrow (Achillea millefolium Linnaeus), cinnamon (Cinnamomum zeylanicum Blume) and rosemary (Rosemarinus officinalis Linnaeus) hydrosols on the some immunological and hematological parameters of common carp (Cyprinus carpio L., 1758).

In this study, the effects of some plant hydrosols (distilled plant waters) based upon some hematological parameters and Nitroblue Tetrazolium (NBT) activities in the common carp (Cyprinus carpio Linnaeus, 1758) infected with Yersinia ruckeri were investigated. In the trial, it was utilized totally 200 common carps with 54.3±6.7 g mean live weight and 15.7±1.8 cm mean total lenght. The 10% rate of the common yarrow (Achillea millefolium Linnaeus) hydrosol; 0.5% rate of the cinnamon (Cinnamomum zeylanicum Blume) hydrosol; and 5% rate of the rosemary (Rosemarinus officinalis Linnaeus) hydrosol were applied to fish as a bath treatment. The erythrocyte (RBC), leukocyte count (WBC), hematocrit value (HCT), haemoglobin amount (Hg), mean corpuscular volume (MCV), mean corpuscular haemoglobin (M...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sw4TAp

STAT6 variants and non-atopic asthma in Pakistani population.

Authors: Riaz A, Ahsan Riaz M, Khan L, Shareef Masoud M, Hussain G, Iqbal M, Qasim M Abstract Asthma a chronic airway inflammatory disease mainly characterized by airways obstruction. Airway hyper responsiveness particularly in eosinophils and inflammatory mediators affect the bronchial mucosa. Genetic association studies show the association of single nucleotide polymorphisms (SNPs) in the STAT6 gene with asthma risk. Role of Signal transducer and activator of transcription 6 (STAT6) is acute for T-helper 2 (Th2) mediated responses during allergic airway diseases. Objective was to investigate whether the two single nucleotide polymorphism (rs4559 and rs324011) in STAT6 gene are associated with non-atopic asthma risk in Pakistani population. One hundred (100) asthma patients with a...

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Ebola Virus Infection Associated with Transmission from Survivors.

Authors: Den Boon S, Marston BJ, Nyenswah TG, Jambai A, Barry M, Keita S, Durski K, Senesie SS, Perkins D, Shah A, Green HH, Hamblion EL, Lamunu M, Gasasira A, Mahmoud NO, Djingarey MH, Morgan O, Crozier I, Dye C Abstract Ebola virus (EBOV) can persist in immunologically protected body sites in survivors of Ebola virus disease, creating the potential to initiate new chains of transmission. From the outbreak in West Africa during 2014-2016, we identified 13 possible events of viral persistence-derived transmission of EBOV (VPDTe) and applied predefined criteria to classify transmission events based on the strength of evidence for VPDTe and source and route of transmission. For 8 events, a recipient case was identified; possible source cases were identified for 5 of these 8. For 5 ev...

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Immunological effects of the intraparenchymal administration of allogeneic and autologous adipose-derived mesenchymal stem cells after the acute phase of middle cerebral artery occlusion in rats

This study was aimed at analyzi... (Source: Journal of Translational Medicine)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Eg7xra

Recurrence of allergic bronchopulmonary aspergillosis after adjunctive surgery for aspergilloma: a case report with long-term follow-up

Coexistence of aspergilloma and allergic bronchopulmonary aspergillosis (ABPA) has rarely been reported. Although the treatment for ABPA includes administration of corticosteroids and antifungal agents, little... (Source: BMC Pulmonary Medicine)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sx1SjA

Newly identified T cells could play a role in cancer and other diseases

FINDINGSResearchers from the UCLA Jonsson Comprehensive Cancer Center and the La Jolla Institute for Immunology have identified a new type of T cell called a phospholipid-reactive T cell that is able to recognize phospholipids, the molecules that help form cells ' outer membranes.The scientists also discovered that phospholipids compete with glycolipids, another type of molecule that helps form cells ' outer membranes, in a way that prevents glycolipids from readily reaching the surface of a cell.BACKGROUNDCell membranes are primarily made up of two types of lipids — phospholipids and glycolipids. Inside cells, these lipids bind to a molecule called CD1d that transports them to the surface. Once there, phospholipids stimulate phospholipid-reactive T cells, and glycolipids stimulate a...

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CZI awards over $64 million to fight neurodegenerative disorders

(Chan Zuckerberg Initiative) Today, the Chan Zuckerberg Initiative (CZI) announced $64.25 million in funding and its selection of 17 early career investigators and nine collaborative science teams to launch the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields -- neuroscience, cell biology, biochemistry, immunology, and genomics -- along with computational biologists and physicians, to understand the underlying causes of neurodegenerative disorders. (Source: EurekAlert! - Medicine and Health)

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Correlations between cervical spinal cord magnetic resonance diffusion tensor and diffusion kurtosis imaging metrics and motor performance in patients with chronic ischemic brain lesions of the corticospinal tract

Abstract

Purpose

To investigate modifications of Magnetic Resonance Diffusion Tensor Imaging (DTI) and Diffusion Kurtosis Imaging (DKI) metrics in lateral white matter (WM) bundles of the cervical spinal cord in patients with previous stroke in the vascular territory of the middle cerebral artery (MCA).

Methods

Twenty consecutive patients with a previous ischemic stroke of the MCA territory and a varying degree of upper motor impairment were enrolled. DKI was centered at the C3C4 and C5C6 intervertebral level.

Results

The fractional anisotropy (FA) values in C3C4 and C5C6 were found to be significantly lower in the lateral WM bundles contralateral to the ischemic lesion and thus, in the WM bundle including the affected corticospinal tract (CST) (p = 0.005 and p = 0.008, respectively), as well as mean kurtosis (MK) and axonal water fraction (AWF) values (p = 0.004 and p = 0.04. respectively). FA values correlated significantly with the Global Motor Index (GMI) both for C3C4 (ρ = 0.61, p = 0.004) and C5C6 (ρ = 0.69, p = 0.002). At C3C4, AWF correlated significantly with GMI (ρ = 0.54, p = 0.03). No correlations were found between lateral WM bundle volumes and GMI.

Conclusion

A reduction of anisotropy and microstructural complexity in the affected lateral WM bundle of the cervical spinal cord was observed in patients with previous ischemic stroke involving the CST. The correlations between these metrics and motor performance were statistically significant.

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Correlations between cervical spinal cord magnetic resonance diffusion tensor and diffusion kurtosis imaging metrics and motor performance in patients with chronic ischemic brain lesions of the corticospinal tract

Abstract

Purpose

To investigate modifications of Magnetic Resonance Diffusion Tensor Imaging (DTI) and Diffusion Kurtosis Imaging (DKI) metrics in lateral white matter (WM) bundles of the cervical spinal cord in patients with previous stroke in the vascular territory of the middle cerebral artery (MCA).

Methods

Twenty consecutive patients with a previous ischemic stroke of the MCA territory and a varying degree of upper motor impairment were enrolled. DKI was centered at the C3C4 and C5C6 intervertebral level.

Results

The fractional anisotropy (FA) values in C3C4 and C5C6 were found to be significantly lower in the lateral WM bundles contralateral to the ischemic lesion and thus, in the WM bundle including the affected corticospinal tract (CST) (p = 0.005 and p = 0.008, respectively), as well as mean kurtosis (MK) and axonal water fraction (AWF) values (p = 0.004 and p = 0.04. respectively). FA values correlated significantly with the Global Motor Index (GMI) both for C3C4 (ρ = 0.61, p = 0.004) and C5C6 (ρ = 0.69, p = 0.002). At C3C4, AWF correlated significantly with GMI (ρ = 0.54, p = 0.03). No correlations were found between lateral WM bundle volumes and GMI.

Conclusion

A reduction of anisotropy and microstructural complexity in the affected lateral WM bundle of the cervical spinal cord was observed in patients with previous ischemic stroke involving the CST. The correlations between these metrics and motor performance were statistically significant.

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Language evaluation in children with pre-lingual hearing loss and cochlear implant

ConclusionThe longer duration of the cochlear implant use, the younger age at surgery and the better performance in the auditory perception of speech influenced the performance in expressive and receptive oral language skills, but not in all the studied semantic categories.ResumoIntroduçãoO implante coclear é um tratamento eficaz para crianças com deficiência auditiva pré-lingual de grau severo e/ou profundo, uma vez que proporciona melhoria considerável na aquisição da linguagem oral por meio da via auditiva. O uso do implante coclear contribui para o desenvolvimento da percepção auditiva favorecendo a aquisição dos processos linguísticos voltados à aquisição de habilidades comunicativas que poderá repercutir positivamente em outras áreas do desenvolvimento.ObjetivoO ob...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Efkwcw

Language evaluation in children with pre-lingual hearing loss and cochlear implant

ConclusionThe longer duration of the cochlear implant use, the younger age at surgery and the better performance in the auditory perception of speech influenced the performance in expressive and receptive oral language skills, but not in all the studied semantic categories.ResumoIntroduçãoO implante coclear é um tratamento eficaz para crianças com deficiência auditiva pré-lingual de grau severo e/ou profundo, uma vez que proporciona melhoria considerável na aquisição da linguagem oral por meio da via auditiva. O uso do implante coclear contribui para o desenvolvimento da percepção auditiva favorecendo a aquisição dos processos linguísticos voltados à aquisição de habilidades comunicativas que poderá repercutir positivamente em outras áreas do desenvolvimento.ObjetivoO ob...

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Ocular Surface Stem Cell Transplantation for Treatment of Keratitis–Ichthyosis–Deafness Syndrome

Conclusions: KID syndrome is a rare cause of LSCD. Although OSST can stabilize the surface, long-term treatment of KID syndrome can be challenging. An lr-CLAL may offer further benefit over a KLAL in these eyes because it is HLA- and ABO-matched tissue; it also helps to treat keratoconjunctivitis sicca, often a prominent feature of KID syndrome. (Source: Cornea)

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Three‐dimensional structure of the wheat β‐amylase Tri a 17, a clinically relevant food allergen

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The relationship of habitual diet with oesophageal inflammation and integrity in Eosinophilic Esophagitis

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Smoking habits among adolescents with asthma – data from a population based birth cohort

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Long‐term outcomes in chronic hypersensitivity pneumonitis

Abstract

Introduction

The objective of this study was to analyze mortality, possible predictors of long‐term survival and health‐related quality of life of a large chronic hypersensitivity pneumonitis (CHP) patient sample.

Methods

Longitudinal study in patients diagnosed with CHP during 2004‐2013, followed for at least one year. Patients remaining alive and consenting to participate had a follow‐up visit during 2015, including a complete pulmonary function study and the EuroQol‐5D and Beck Depression and Anxiety Inventories.

Results

Out of the 160 patients finally included, 87 remained alive. Seventy‐three had died or underwent lung transplantation at the time of the study with a median survival of 7.0 (4.4‐14.5) years. A Cox proportional risk model showed that factors associated with lower survival were: increased age, a low percentage of lymphocytes in bronchoalveolar lavage (BAL), a decreased transfer factor of the lung for carbon monoxide (DLCO), presence of honeycomb in the high resolution chest scan (HRCT) and the usual interstitial pneumonia (UIP) histologic pattern. At follow‐up all patients presented an EuroQol‐5D score < 0.8 and 21(50%) and 9(28.6%) subjects presented a probable anxiety and depressive syndrome, respectively.

Conclusion

CHP is a severe disease with a bad mid‐term prognosis. Lymphocyte values in BAL and DLCO values at baseline, presence of honeycomb in HRCT and UIP histologic pattern were found to be predictors of survival. Early accurate diagnosis of the disease is fundamental for prompt initiation of antigen avoidance.

This article is protected by copyright. All rights reserved.

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The WHO/IUIS Allergen Nomenclature

Summary

The WHO/IUIS Allergen Nomenclature Sub‐Committee (http://www.allergen.org/), an international body of experts, has developed an allergen nomenclature system to provide a common language for unambiguous communications between researchers, clinicians, pharmaceutical companies and regulatory authorities regarding specific allergenic proteins. Official allergen names are only assigned by the WHO/IUIS Nomenclature Sub‐Committee once a new allergen has successfully undergone the submission and evaluation process. This article highlights the necessary steps to obtain an official allergen name and the high importance of having an official allergen nomenclature.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Eii5pu

Three‐dimensional structure of the wheat β‐amylase Tri a 17, a clinically relevant food allergen

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EfTYI2

The relationship of habitual diet with oesophageal inflammation and integrity in Eosinophilic Esophagitis

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sty5rS

Smoking habits among adolescents with asthma – data from a population based birth cohort

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EeGjB7

Long‐term outcomes in chronic hypersensitivity pneumonitis

Abstract

Introduction

The objective of this study was to analyze mortality, possible predictors of long‐term survival and health‐related quality of life of a large chronic hypersensitivity pneumonitis (CHP) patient sample.

Methods

Longitudinal study in patients diagnosed with CHP during 2004‐2013, followed for at least one year. Patients remaining alive and consenting to participate had a follow‐up visit during 2015, including a complete pulmonary function study and the EuroQol‐5D and Beck Depression and Anxiety Inventories.

Results

Out of the 160 patients finally included, 87 remained alive. Seventy‐three had died or underwent lung transplantation at the time of the study with a median survival of 7.0 (4.4‐14.5) years. A Cox proportional risk model showed that factors associated with lower survival were: increased age, a low percentage of lymphocytes in bronchoalveolar lavage (BAL), a decreased transfer factor of the lung for carbon monoxide (DLCO), presence of honeycomb in the high resolution chest scan (HRCT) and the usual interstitial pneumonia (UIP) histologic pattern. At follow‐up all patients presented an EuroQol‐5D score < 0.8 and 21(50%) and 9(28.6%) subjects presented a probable anxiety and depressive syndrome, respectively.

Conclusion

CHP is a severe disease with a bad mid‐term prognosis. Lymphocyte values in BAL and DLCO values at baseline, presence of honeycomb in HRCT and UIP histologic pattern were found to be predictors of survival. Early accurate diagnosis of the disease is fundamental for prompt initiation of antigen avoidance.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2StxZR2

The WHO/IUIS Allergen Nomenclature

Summary

The WHO/IUIS Allergen Nomenclature Sub‐Committee (http://www.allergen.org/), an international body of experts, has developed an allergen nomenclature system to provide a common language for unambiguous communications between researchers, clinicians, pharmaceutical companies and regulatory authorities regarding specific allergenic proteins. Official allergen names are only assigned by the WHO/IUIS Nomenclature Sub‐Committee once a new allergen has successfully undergone the submission and evaluation process. This article highlights the necessary steps to obtain an official allergen name and the high importance of having an official allergen nomenclature.

This article is protected by copyright. All rights reserved.

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Test for Respiratory and Asthma Control in Kids (TRACK): validation of the Portuguese version

ConclusionWe have demonstrated that the Portuguese version of the TRACK questionnaire has satisfactory reliability (internal consistency), adequate criterion validity (compared against GINA levels of control) and constructive validity (compared against respiratory symptoms and medical opinion), showing that it can be a useful tool to discriminate among children with different levels of respiratory symptom control.Trial registrationClinicalTrials.gov:NCT03290222. (Source: World Allergy Organization Journal)

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Test for Respiratory and Asthma Control in Kids (TRACK): validation of the Portuguese version

ConclusionWe have demonstrated that the Portuguese version of the TRACK questionnaire has satisfactory reliability (internal consistency), adequate criterion validity (compared against GINA levels of control) and constructive validity (compared against respiratory symptoms and medical opinion), showing that it can be a useful tool to discriminate among children with different levels of respiratory symptom control.Trial registrationClinicalTrials.gov:NCT03290222. (Source: World Allergy Organization Journal)

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Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease

Publication date: February 2019Source: Microbial Pathogenesis, Volume 127Author(s): Pourya Gholizadeh, Majid Mahallei, Ali Pormohammad, Mojtaba Varshochi, Khudaverdi Ganbarov, Elham Zeinalzadeh, Bahman Yousefi, Milad Bastami, Asghar Tanomand, Suhad Saad Mahmood, Mehdi Yousefi, Mohammad Asgharzadeh, Hossein Samadi KafilAbstractRecent studies have been considered to symbiotic interactions of the human gastrointestinal microbiota and human lifestyle-related disorders. The human gastrointestinal microbiota continuously stimulates the immune system against opportunistic and pathogen bacteria from infancy. Changes in gastrointestinal microbiota have been associated with numbers of human diseases such as allergic diseases, autoimmune encephalitis, atherosclerosis, colorectal cancer, obesity, diab...

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Marjoram Extract Down-regulates the Expression of Pasteurella multocida Adhesion, Colonization and Toxin genes: a Potential Mechanism for its Antimicrobial activity

This study provides an in vitro research framework to investigate the antibacterial activities of 5 herbal (marjoram, garlic, onion, cinnamon and black seed) extracts against 16 multidrug-resistant and virulent P. multocida serogroup A isolates recovered from dead and clinically diseased rabbits. Pathogenicity of the screened isolates was further proven experimentally and was verified by PCR analyses of 5 randomly selected virulence genes encoding attachment and colonization proteins (ptfA, pfhA, and omp87), sialidases (nanB) and dermonecrotoxin (toxA). A total of 12 P. multocida isolates were highly pathogenic with the possession of the examined virulence genes, while the other 4 isolates were of lower pathogenicity with expression of the target genes except toxA. In vitro anti-P. multoci...

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Allergic Contact Dermatitis Due to Chlorhexidine in 2 Pediatric Patient

Publication date: Available online 5 December 2018Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): S. Córdoba, T. Sanz-Sánchez, E. Mohedano-Vicente, J. Borbujo (Source: Actas Dermo-Sifiliograficas)

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Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease

Publication date: February 2019Source: Microbial Pathogenesis, Volume 127Author(s): Pourya Gholizadeh, Majid Mahallei, Ali Pormohammad, Mojtaba Varshochi, Khudaverdi Ganbarov, Elham Zeinalzadeh, Bahman Yousefi, Milad Bastami, Asghar Tanomand, Suhad Saad Mahmood, Mehdi Yousefi, Mohammad Asgharzadeh, Hossein Samadi KafilAbstractRecent studies have been considered to symbiotic interactions of the human gastrointestinal microbiota and human lifestyle-related disorders. The human gastrointestinal microbiota continuously stimulates the immune system against opportunistic and pathogen bacteria from infancy. Changes in gastrointestinal microbiota have been associated with numbers of human diseases such as allergic diseases, autoimmune encephalitis, atherosclerosis, colorectal cancer, obesity, diab...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E0vLVn

Marjoram Extract Down-regulates the Expression of Pasteurella multocida Adhesion, Colonization and Toxin genes: a Potential Mechanism for its Antimicrobial activity

This study provides an in vitro research framework to investigate the antibacterial activities of 5 herbal (marjoram, garlic, onion, cinnamon and black seed) extracts against 16 multidrug-resistant and virulent P. multocida serogroup A isolates recovered from dead and clinically diseased rabbits. Pathogenicity of the screened isolates was further proven experimentally and was verified by PCR analyses of 5 randomly selected virulence genes encoding attachment and colonization proteins (ptfA, pfhA, and omp87), sialidases (nanB) and dermonecrotoxin (toxA). A total of 12 P. multocida isolates were highly pathogenic with the possession of the examined virulence genes, while the other 4 isolates were of lower pathogenicity with expression of the target genes except toxA. In vitro anti-P. multoci...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QIKGKN

Allergic Contact Dermatitis Due to Chlorhexidine in 2 Pediatric Patient

Publication date: Available online 5 December 2018Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): S. Córdoba, T. Sanz-Sánchez, E. Mohedano-Vicente, J. Borbujo (Source: Actas Dermo-Sifiliograficas)

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Dysphagia diagnosis with questionnaire, tongue strength measurement, and FEES in patients with childhood-onset muscular dystrophy

Publication date: Available online 5 December 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Athanasia Printza, Charalambos Goutsikas, Stefanos Triaridis, Athanasios Kyrgidis, Katerina Haidopoulou, Jannis Constantinidis, Evagelos Pavlou

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Dysphagia diagnosis with questionnaire, tongue strength measurement, and FEES in patients with childhood-onset muscular dystrophy

Publication date: Available online 5 December 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Athanasia Printza, Charalambos Goutsikas, Stefanos Triaridis, Athanasios Kyrgidis, Katerina Haidopoulou, Jannis Constantinidis, Evagelos Pavlou

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Does suturing tonsil pillars post-tonsillectomy reduce postoperative hemorrhage?: A Literature Review

Publication date: Available online 4 December 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Jacqueline A. Wulu, Melissa Chua, Jessica R. Levi

Abstract

Objective

Literature review comparing post-tonsillectomy hemorrhage in pediatric and adult patients with and without suturing tonsil pillars to investigate whether suturing tonsil pillars reduces the risk of post-tonsillectomy hemorrhage.

Review

methods; Online journal databases were searched using the key phrases "post tonsillectomy hemorrhage", "post tonsillectomy bleed", and "tonsil pillar suture". 10 published studies were found regarding tonsil pillar suturing, four directly related to postoperative bleeding and five focusing on postoperative pain reduction. There was one study that evaluated both pain and bleeding. The pain reduction studies were comprised of 225 patients while the postoperative bleeding studies included 3987 patients.

Conclusions

Suturing tonsil pillars after tonsillectomy may be beneficial after cold tonsillectomy.

Implications for practice; Post-operative bleeding is one of the most common complications that can result in increased patient distress and hospitalization. In this article, we provide literature review of tonsil pillar suturing and post-tonsillectomy hemorrhage. Our study suggests suturing the tonsil pillars immediately post-tonsillectomy may reduce the risk of severe post-operative bleeding requiring return to the operating room for certain patients.

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Peanut Allergy

Title: Peanut AllergyCategory: Diseases and ConditionsCreated: 12/20/2000 12:00:00 AMLast Editorial Review: 12/4/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Peanut Allergy

Title: Peanut AllergyCategory: Diseases and ConditionsCreated: 12/20/2000 12:00:00 AMLast Editorial Review: 12/4/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Differences in perceptions of e-cigarettes across daily and non-daily users

Publication date: Available online 5 December 2018

Source: Addictive Behaviors

Author(s): Nubia A. Mayorga, Lorra Garey, Michael J. Zvolensky

Abstract

Objective

E-cigarette use has increased significantly over the past decade. Among the growing population of e-cigarette users, several pattern-based subgroups have emerged, including daily and non-daily users. Daily users are at greater risk for experiencing negative health consequences from use. Yet, little is understood about underlying e-cigarette processes that may be related to daily use relative to non-daily use.

Method

The present study sought to investigate differences in three clinically-relevant e-cigarette processes, including perceived risks (including both absolute and comparable risks to combustible cigarettes), benefits, and innovation of e-cigarettes between daily and non-daily users. The study included 564 adult current e-cigarette users (51.1% female, M_age = 35.1 years, SD = 10.2).

Results

Results indicated a significant difference in levels of perception for all three dependent variables, such that daily users reported a higher level of perceived risks, benefits, and innovation for e-cigarettes.

Conclusions

Overall, the current study provides empirical evidence that perceived risks, benefits and innovations may be more strongly endorsed by more daily e-cigarette uses. Importantly, this study adds to evolving, but thus far limited, knowledge of e-cigarettes by highlighting how frequency of e-cigarette use relates to beliefs about e-cigarette use.

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Tobacco smoking and opioid use disorders: A meta-analysis

Publication date: Available online 4 December 2018

Source: Addictive Behaviors

Author(s): Abdolhalim Rajabi, Mohsen Dehghani, Azadeh Shojaei, Mojtaba Farjam, Seyed Abbas Motevalian

Abstract

Background

Tobacco smoking has been shown a major risk factor for opioid use disorders in several observational studies, but the results are inconsistent. We conducted a systematic review and meta-analysis of observational studies to investigate the association between smoking behaviors and opioid use disorders.

Methods

We performed a systematic literature search of Medline, Embase, Scopus, ISI Web of Science, and Google Scholar through October 2017, using MeSH terms related to smoking, opioid, and opiate. The reference list of retrieved article was also examined. We calculated pooled odds ratio (ORs) with 95% confidence intervals (CIs) using fixed and random-effects models. Subgroup analyses was performed using participants and studies characteristics to assess the sources of heterogeneity.

Results

We identified 11 eligible observational studies (7 cohort and 4 population based cross-sectional studies) with 199,411 participants. The pooled OR of opioid use disorders was 3.18 (95% CI: 2.37–4.25) for current smoking compared with nonsmoking. Pooled OR for prevalent cases of opiate use disorders were 13.78 (95% CI: 6.81–27.89), pooled OR for prevalent cases of opioid use disorders were 3.15 (95% CI: 2.62–3.80) and pooled OR for incident cases of opiate use disorders were 1.86 (95% CI: 1.39–2.49). Opioid use disorders was positively associated with earlier age of onset tobacco smoking (pooled OR = 1.66; 95% CI: 1.33–2.07).

Conclusion

The results of present meta-analysis confirm that tobacco smoking is associated with opioid use disorders development. If the association between smoking and risk of opioid use disorders is causal or gateway public health efforts to reduce smoking could have a substantial effect on the worldwide burden of opioid use disorders.

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