AbstractAdipose tissue is a target ofTrypanosoma cruzi infection being a parasite reservoir during the chronic phase in mice and humans. Previously, we reported that acuteTrypanosoma cruzi infection in mice is linked to a severe adipose tissue loss, probably triggered by inflammation, as well as by the parasite itself. Here, we evaluated how infection affects adipose tissue homeostasis, considering adipocyte anabolic and catabolic pathways, the immune –endocrine pattern and the possible repercussion upon adipogenesis. During in vivo infection, both lipolytic and lipogenic pathways are profoundly affected, since the expression of lipolytic enzymes and lipogenic enzymes was intensely downregulated. A similar pattern was observed in isolated adipo cytes from infected animals and in 3T3-L1 a...
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Πέμπτη 8 Νοεμβρίου 2018
Immune response triggered by Trypanosoma cruzi infection strikes adipose tissue homeostasis altering lipid storage, enzyme profile and adipokine expression
Immune response triggered by Trypanosoma cruzi infection strikes adipose tissue homeostasis altering lipid storage, enzyme profile and adipokine expression
AbstractAdipose tissue is a target ofTrypanosoma cruzi infection being a parasite reservoir during the chronic phase in mice and humans. Previously, we reported that acuteTrypanosoma cruzi infection in mice is linked to a severe adipose tissue loss, probably triggered by inflammation, as well as by the parasite itself. Here, we evaluated how infection affects adipose tissue homeostasis, considering adipocyte anabolic and catabolic pathways, the immune –endocrine pattern and the possible repercussion upon adipogenesis. During in vivo infection, both lipolytic and lipogenic pathways are profoundly affected, since the expression of lipolytic enzymes and lipogenic enzymes was intensely downregulated. A similar pattern was observed in isolated adipo cytes from infected animals and in 3T3-L1 a...
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Editorial Board
Publication date: November 2018Source: Speech Communication, Volume 104Author(s): (Source: Speech Communication)
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Measuring Articulation Rate: A Comparison of Two Methods
Conclusions The MAR method is a valid method to measure articulation rate. However, it cannot be used interchangeably with the prevailing global method. Further standardization of the MAR method is needed before general clinical use can be suggested. (Source: Journal of Speech, Language, and Hearing Research)
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Treating Speech Movement Hypokinesia in Parkinson's Disease: Does Movement Size Matter?
Conclusions This study demonstrated that using an augmented visual feedback approach is beneficial, beyond a verbal cue alone, in addressing articulatory hypokinesia in individuals with PD. An optimal degree of articulatory expansion might, however, be required to elicit a speech intelligibility benefit. (Source: Journal of Speech, Language, and Hearing Research)
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Introduction to the Research Symposium Forum
Purpose The purpose of this introduction is to provide an overview of the articles contained within this research forum ofJSLHR. Each of these articles is based upon presentations from the 2017 ASHA Research Symposium. (Source: Journal of Speech, Language, and Hearing Research)
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Time Course of the Second Morpheme Processing During Spoken Disyllabic Compound Word Recognition in Chinese
Conclusion Findings in this study suggest that semantic information of both the 2nd morpheme and the whole word of a compound was activated in spoken word recognition and that the meaning activation of the 2nd morpheme followed the activation of the whole word. (Source: Journal of Speech, Language, and Hearing Research)
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Changing Developmental Trajectories of Toddlers With Autism Spectrum Disorder: Strategies for Bridging Research to Community Practice
Conclusions Current health care and education systems are challenged to provide intervention of adequate intensity for toddlers with ASD. The use of innovative technology can increase acceleration of access to evidence-based early intervention for toddlers with ASD that addresses health disparities, enables immediate response as soon as ASD is suspected, and rapidly bridges the research-to-practice gap.Presentation Videohttps://doi.org/10.23641/asha.7297817 (Source: Journal of Speech, Language, and Hearing Research)
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Masthead
(Source: Journal of Speech, Language, and Hearing Research)
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Human Voice as a Measure of Mental Load Level
Conclusions Some acoustic parameters of the human voice could be an appropriate and efficient means for detecting mental load levels. (Source: Journal of Speech, Language, and Hearing Research)
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Minimally Detectable Change and Minimal Clinically Important Difference of a Decline in Sentence Intelligibility and Speaking Rate for Individuals With Amyotrophic Lateral Sclerosis
Conclusions The findings suggest that declines greater than 12% sentence intelligibility and 37 WPM are required to be outside measurement error and that these estimates vary widely across dysarthria severities. The MDC and MCID metrics used in this study to detect real and clinically relevant change should be estimated for other measures of speech outcomes in intervention research. (Source: Journal of Speech, Language, and Hearing Research)
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Lexical Development in Young Children With Autism Spectrum Disorder (ASD): How ASD May Affect Intake From the Input
Conclusion Our review of studies that examine lexical development in children with ASD suggests that innovative intervention approaches that take into account both the social communication and processing demands of the learning situation may be particularly beneficial. (Source: Journal of Speech, Language, and Hearing Research)
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The Dimensionality of Oral Language in Kindergarten Spanish –English Dual Language Learners
Conclusions These results indicate that a general language ability may underlie development in both Spanish and English. In contrast to a unidimensional structure found for monolingual English-speaking kindergarteners, oral language appears to be multidimensional in Spanish –English DLL kindergarteners, but multidimensionality is reflected in Spanish, not English. (Source: Journal of Speech, Language, and Hearing Research)
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Early Motor and Communicative Development in Infants With an Older Sibling With Autism Spectrum Disorder
Conclusions Advances in communicative and language development are supported by advances in motor skill. When these advances are slowed and/or when new skills are not consolidated and remain challenging for the infant, the enhanced potential for exploration afforded by new abilities and the concomitant increase in opportunities for learning are reduced. Improving our understanding of communicative delays of the sort observed in ASD and developing effective intervention methods requires going beyond the individual to consider the constant, complex interplay between developing communicators and their environments.Presentation Videohttps://doi.org/10.23641/asha.7299308 (Source: Journal of Speech, Language, and Hearing Research)
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Editorial Board
Publication date: November 2018Source: Speech Communication, Volume 104Author(s): (Source: Speech Communication)
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Plosive voicing acoustics and voice quality in Yerevan Armenian
Publication date: November 2018Source: Journal of Phonetics, Volume 71Author(s): Scott Seyfarth, Marc GarellekAbstractYerevan Armenian is a variety of Eastern Armenian with a three-way voicing contrast that includes voiced, voiceless unaspirated, and voiceless aspirated stops, but previous work has not converged on a description of how voice quality is involved in the contrast. We demonstrate how voice quality can be assessed in a two-dimensional acoustic space using a spectral tilt measure in conjunction with a measure of spectral noise. Eight speakers produced a list of words with prevocalic word-initial and postvocalic word-final plosives. The results suggest that Yerevan Armenian has breathy-voiced plosives which are produced with closure voicing and a relatively spread glottis that is...
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Accumulation of protoporphyrin IX in medulloblastoma cell lines and sensitivity to subsequent photodynamic treatment
ConclusionMedulloblastoma cell lines accumulate PPIX after application of 5-ALA and become sensitive to PDT, associated with low ferrochelatase expression and activity. Photosensitivity is more pronounced in MYC-amplified cell lines. In contrast to GBM cells, however, PPIX accumulation appears to be reduced, restricted to a subset of cells and associated with lower photosensitivity of the MB cell lines, possibly due to expression of the ABCG2 transporter protein CD338 on MB cells. (Source: Journal of Photochemistry and Photobiology B: Biology)
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Treating Speech Movement Hypokinesia in Parkinson's Disease: Does Movement Size Matter?
Conclusions This study demonstrated that using an augmented visual feedback approach is beneficial, beyond a verbal cue alone, in addressing articulatory hypokinesia in individuals with PD. An optimal degree of articulatory expansion might, however, be required to elicit a speech intelligibility benefit. (Source: Journal of Speech, Language, and Hearing Research)
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Introduction to the Research Symposium Forum
Purpose The purpose of this introduction is to provide an overview of the articles contained within this research forum ofJSLHR. Each of these articles is based upon presentations from the 2017 ASHA Research Symposium. (Source: Journal of Speech, Language, and Hearing Research)
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Time Course of the Second Morpheme Processing During Spoken Disyllabic Compound Word Recognition in Chinese
Conclusion Findings in this study suggest that semantic information of both the 2nd morpheme and the whole word of a compound was activated in spoken word recognition and that the meaning activation of the 2nd morpheme followed the activation of the whole word. (Source: Journal of Speech, Language, and Hearing Research)
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Changing Developmental Trajectories of Toddlers With Autism Spectrum Disorder: Strategies for Bridging Research to Community Practice
Conclusions Current health care and education systems are challenged to provide intervention of adequate intensity for toddlers with ASD. The use of innovative technology can increase acceleration of access to evidence-based early intervention for toddlers with ASD that addresses health disparities, enables immediate response as soon as ASD is suspected, and rapidly bridges the research-to-practice gap.Presentation Videohttps://doi.org/10.23641/asha.7297817 (Source: Journal of Speech, Language, and Hearing Research)
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Human Voice as a Measure of Mental Load Level
Conclusions Some acoustic parameters of the human voice could be an appropriate and efficient means for detecting mental load levels. (Source: Journal of Speech, Language, and Hearing Research)
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Executive Function Skills in School-Age Children With Autism Spectrum Disorder: Association With Language Abilities
Conclusions There is a need for future research to examine the direction of influence between EF and language. It would be beneficial for EF interventions with children with ASD to consider language outcomes and, conversely, to examine whether specific language training facilitates aspects of executive control in children on the autism spectrum.Presentation Videohttps://doi.org/10.23641/asha.7298144 (Source: Journal of Speech, Language, and Hearing Research)
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Minimally Detectable Change and Minimal Clinically Important Difference of a Decline in Sentence Intelligibility and Speaking Rate for Individuals With Amyotrophic Lateral Sclerosis
Conclusions The findings suggest that declines greater than 12% sentence intelligibility and 37 WPM are required to be outside measurement error and that these estimates vary widely across dysarthria severities. The MDC and MCID metrics used in this study to detect real and clinically relevant change should be estimated for other measures of speech outcomes in intervention research. (Source: Journal of Speech, Language, and Hearing Research)
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The Dimensionality of Oral Language in Kindergarten Spanish –English Dual Language Learners
Conclusions These results indicate that a general language ability may underlie development in both Spanish and English. In contrast to a unidimensional structure found for monolingual English-speaking kindergarteners, oral language appears to be multidimensional in Spanish –English DLL kindergarteners, but multidimensionality is reflected in Spanish, not English. (Source: Journal of Speech, Language, and Hearing Research)
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Early Motor and Communicative Development in Infants With an Older Sibling With Autism Spectrum Disorder
Conclusions Advances in communicative and language development are supported by advances in motor skill. When these advances are slowed and/or when new skills are not consolidated and remain challenging for the infant, the enhanced potential for exploration afforded by new abilities and the concomitant increase in opportunities for learning are reduced. Improving our understanding of communicative delays of the sort observed in ASD and developing effective intervention methods requires going beyond the individual to consider the constant, complex interplay between developing communicators and their environments.Presentation Videohttps://doi.org/10.23641/asha.7299308 (Source: Journal of Speech, Language, and Hearing Research)
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The Shape Bias in Children With Autism Spectrum Disorder: Potential Sources of Individual Differences
Conclusions These findings suggest that no single account sufficiently explains the observed individual differences in shape bias performance in children with ASD. Nonetheless, these findings break new ground in highlighting the role of social communicative interactions as integral to understanding specific language outcomes (i.e., the shape bias) in children with ASD, especially those with low verbal abilities, and point to new hypotheses concerning the linguistic content of these interactions.Presentation Videohttps://doi.org/10.23641/asha.7299581 (Source: Journal of Speech, Language, and Hearing Research)
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Effect of Dual-Carrier Processing on the Intelligibility of Concurrent Vocoded Sentences
Conclusions The data showed a clear benefit of using a distinct carrier to convey each sentence (i.e., DC processing). Accordingly, the poor speech intelligibility in noise typically observed with SC-vocoded speech may be partly attributed to the envelope of independent sound sources sharing the same carrier. Moreover, this work suggests that noise reduction may not be the only viable option to improve speech intelligibility in noise for users of cochlear implants. Alternative approaches aimed at enhancing sound source segregation such as DC processing may help to improve speech intelligibility while preserving and enhancing the background. (Source: Journal of Speech, Language, and Hearing Research)
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Spontaneous Otoacoustic Emissions Reveal an Efficient Auditory Efferent Network
Conclusions The results suggest that even the earliest stages of speech comprehension are modulated by top-down influences, resulting in changes to SOAEs depending on the presence of bimodal or unimodal input. Neural processes responsible for changes in cochlear function are sensitive to redundancy across auditory and visual input channels and coordinate activity to maximize efficiency in the auditory periphery. (Source: Journal of Speech, Language, and Hearing Research)
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Spontaneous Otoacoustic Emissions Reveal an Efficient Auditory Efferent Network
Conclusions The results suggest that even the earliest stages of speech comprehension are modulated by top-down influences, resulting in changes to SOAEs depending on the presence of bimodal or unimodal input. Neural processes responsible for changes in cochlear function are sensitive to redundancy across auditory and visual input channels and coordinate activity to maximize efficiency in the auditory periphery. (Source: Journal of Speech, Language, and Hearing Research)
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“Hanger” in Intubation and Laryngoscopy
Abstract
Achieving an adequate exposure in laryngoscopy is an extremely tedious task for the operating surgeon, especially for the anterior commissure lesions. Various maneuvers have been described to overcome this difficulty, but failed in providing an adequate exposure leading to a poor outcome. To create a device that can deliver uniform pressure over the laryngeal cartilage and succeed in providing an adequate exposure of the glottic lesion. A total of 44 patients were included in the study, divided into two groups containing 22 patients each. The distance at the level of anterior commissure from the superior border of the distal end of the laryngoscope was noted and compared. Group A subjected to digital cricoid pressure showed a mean distance of 9.09 of exposure with variance of 1.22 and Group B subjected to cricoid pressure with the cricoid catapult showed a mean distance of 11.76 with variance of 1.59. The groups were statistically analyzed using Anova Test and the test was found to be very significant (p < 0.0001). The catapult is made of a hanger defining its economics, which has a vital role in difficult intubations especially in anterior placed larynx, short neck and obese patients, also succeeds in providing an adequate exposure of the glottic lesion, (especially the anterior commissure) by delivering uniform pressure over the laryngeal cartilage, leading to a superior operative outcome.
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Completely Endoscopic Approach Using a Skeeter Drill to Treat Bilateral Congenital Choanal Atresia in a 33 Week Born Pre-term Baby
Abstract
Choanal atresia (CA) is a relatively rare condition manifesting with respiratory distress. Endoscopic approaches have superseded transnasal and transpalatal approaches. We present a case of a premature baby of 1.10 kg, who developed respiratory distress and was diagnosed with bilateral CA. A nasal airway was created endoscopically using a skeeter drill.
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Human Immunodeficiency Virus Infection: Does Highly Active Antiretroviral Therapy Influence Ear Nose Throat Manifestations?
Abstract
To study the change in trend of ear, nose and throat (ENT) manifestations in patients who were on treatment, before and after availability of highly active antiretroviral therapy (HAART). To find out the prevalence of ENT manifestations in human immunodeficiency virus (HIV) infected people who were on treatment, in the year of 2004 (before the availability of HAART) and in 2014 (after the availability of HAART). Design A combination of a retrospective and prospective study. Setting Anti Retroviral Therapy (ART) Center at Our Hospital. Subjects Patients with HIV infection on ART. Methods Retrospective review of case records of the patients visiting the center in the year 2004 and prospective study of the patients visiting in the year 2014 was conducted. Sample size was calculated as 200 in each group based on 95% confidence and 96% power. Convenience sampling was used in our study. The prevalence of ENT manifestations in HIV patients were found to be 86% in 2004 and 93% in 2014. Among ENT manifestations oropharyngeal manifestations were most common. Lesser the CD4 count more was the prevalence of disorders in oropharynx. Our study showed a high prevalence of ENT manifestations in HIV patients who were on treatment, irrespective of the gap of 10 years and introduction of HAART therapy. Most common ENT manifestation both in 2004 and 2014 was oropharyngeal candidiasis. Lesser the CD4 count more was the prevalence of disorders in oropharynx.
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Robot Assisted Trans Axillary Thyroidectomy: A Subcontinent Experience
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Functional Nasal Surgery and Use of CPAP in OSAS Patients: Our Experience
Abstract
The surgical correction of nasal obstruction is definitely effective and recommended in patients with poor CPAP compliance, often secondary to the high pressures that need to be given in patients with nasal sub stenosis. For this reason, the objective of this study is the evaluation of the effectiveness and effects of the functional nose surgery on adherence to CPAP- therapy in patients (with moderate to severe OSAS with indication of ventilation therapy) poorly compliant with CPAP. The study was performed on a sample of 52 patients, 40 male and 12 female, aged between 29 and 72 years followed by the Otolaryngology Unit of the University Palermo in the period between January 2015 and January 2017. All patients were subjected to the following s iter: anamnesis with Epworth Sleepiness Scale, NOSE scale, evaluation of "CPAP usage data." Upper airway optical fiber endoscopy with Müller's maneuver. We performed various type of nasal surgery (septoplasty, decongestion of the lower turbinates and FESS) 6 months after the surgery, CPAP usage was evaluated and the NOSE scale has been reapplied. All patients had a subjective degree of obstruction classified in severe or extreme by the NOSE scale before surgery. Almost all patients reported a mild degree of obstruction after the surgery. About CPAP usage, the average usage has passed by 2, 3 h at night to 6, 8 h after the surgery. The result is significant because it shows how the nasal functional surgery can make selected patients suitable to ventilation therapy. As our work shows, a better nasal function allows to reduce the CPAP pressure, Therefore, we believe that all patients with medium to severe obstructive apnea syndrome and for whom night-time ventilation therapy (CPAP) is advised should be evaluated with endoscopy and anamnesis oriented to evaluate nasal obstructive pathologies that may reduce effectiveness of CPAP.
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“Hanger” in Intubation and Laryngoscopy
Abstract
Achieving an adequate exposure in laryngoscopy is an extremely tedious task for the operating surgeon, especially for the anterior commissure lesions. Various maneuvers have been described to overcome this difficulty, but failed in providing an adequate exposure leading to a poor outcome. To create a device that can deliver uniform pressure over the laryngeal cartilage and succeed in providing an adequate exposure of the glottic lesion. A total of 44 patients were included in the study, divided into two groups containing 22 patients each. The distance at the level of anterior commissure from the superior border of the distal end of the laryngoscope was noted and compared. Group A subjected to digital cricoid pressure showed a mean distance of 9.09 of exposure with variance of 1.22 and Group B subjected to cricoid pressure with the cricoid catapult showed a mean distance of 11.76 with variance of 1.59. The groups were statistically analyzed using Anova Test and the test was found to be very significant (p < 0.0001). The catapult is made of a hanger defining its economics, which has a vital role in difficult intubations especially in anterior placed larynx, short neck and obese patients, also succeeds in providing an adequate exposure of the glottic lesion, (especially the anterior commissure) by delivering uniform pressure over the laryngeal cartilage, leading to a superior operative outcome.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JdE8gr
Completely Endoscopic Approach Using a Skeeter Drill to Treat Bilateral Congenital Choanal Atresia in a 33 Week Born Pre-term Baby
Abstract
Choanal atresia (CA) is a relatively rare condition manifesting with respiratory distress. Endoscopic approaches have superseded transnasal and transpalatal approaches. We present a case of a premature baby of 1.10 kg, who developed respiratory distress and was diagnosed with bilateral CA. A nasal airway was created endoscopically using a skeeter drill.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JaOuBc
Human Immunodeficiency Virus Infection: Does Highly Active Antiretroviral Therapy Influence Ear Nose Throat Manifestations?
Abstract
To study the change in trend of ear, nose and throat (ENT) manifestations in patients who were on treatment, before and after availability of highly active antiretroviral therapy (HAART). To find out the prevalence of ENT manifestations in human immunodeficiency virus (HIV) infected people who were on treatment, in the year of 2004 (before the availability of HAART) and in 2014 (after the availability of HAART). Design A combination of a retrospective and prospective study. Setting Anti Retroviral Therapy (ART) Center at Our Hospital. Subjects Patients with HIV infection on ART. Methods Retrospective review of case records of the patients visiting the center in the year 2004 and prospective study of the patients visiting in the year 2014 was conducted. Sample size was calculated as 200 in each group based on 95% confidence and 96% power. Convenience sampling was used in our study. The prevalence of ENT manifestations in HIV patients were found to be 86% in 2004 and 93% in 2014. Among ENT manifestations oropharyngeal manifestations were most common. Lesser the CD4 count more was the prevalence of disorders in oropharynx. Our study showed a high prevalence of ENT manifestations in HIV patients who were on treatment, irrespective of the gap of 10 years and introduction of HAART therapy. Most common ENT manifestation both in 2004 and 2014 was oropharyngeal candidiasis. Lesser the CD4 count more was the prevalence of disorders in oropharynx.
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Robot Assisted Trans Axillary Thyroidectomy: A Subcontinent Experience
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Aural Atresia with Cholesteotoma and Its Management Strategies
Abstract
The term congenital aural atresia is used to describe failure of external auditory canal to open. Thus it results in conductive hearing loss. There are ways to improve the transmission of sound to the healthy inner ear, we have performed surgery to open the ear canal and restore the natural sound-conducting mechanism to the inner ear. Thus avoiding multiple surgeries. The study was conducted among patients aged between 12 and 24 years, our study included 8 patients with aural atresia with cholesteotoma. After a detailed examination of patients were subjected to surgery. In our study with the sample size of eight patients Where, all our patients underwent canal wall down mastoidectomy with simultaneous single stage reconstruction of ossicular chain. All our patients were discharge free and Had subjective improvement in hearing with the post operative period was well accomplished to < 35 dB. In our study all eight patients who underwent canal wall down mastoidectomy had good hearing outcome. As to avoid unnecessary recurrence and complications which are usually seen in intact canal wall down mastoidectomies, we suggest canal wall down and single stage reconstruction.
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Functional Nasal Surgery and Use of CPAP in OSAS Patients: Our Experience
Abstract
The surgical correction of nasal obstruction is definitely effective and recommended in patients with poor CPAP compliance, often secondary to the high pressures that need to be given in patients with nasal sub stenosis. For this reason, the objective of this study is the evaluation of the effectiveness and effects of the functional nose surgery on adherence to CPAP- therapy in patients (with moderate to severe OSAS with indication of ventilation therapy) poorly compliant with CPAP. The study was performed on a sample of 52 patients, 40 male and 12 female, aged between 29 and 72 years followed by the Otolaryngology Unit of the University Palermo in the period between January 2015 and January 2017. All patients were subjected to the following s iter: anamnesis with Epworth Sleepiness Scale, NOSE scale, evaluation of "CPAP usage data." Upper airway optical fiber endoscopy with Müller's maneuver. We performed various type of nasal surgery (septoplasty, decongestion of the lower turbinates and FESS) 6 months after the surgery, CPAP usage was evaluated and the NOSE scale has been reapplied. All patients had a subjective degree of obstruction classified in severe or extreme by the NOSE scale before surgery. Almost all patients reported a mild degree of obstruction after the surgery. About CPAP usage, the average usage has passed by 2, 3 h at night to 6, 8 h after the surgery. The result is significant because it shows how the nasal functional surgery can make selected patients suitable to ventilation therapy. As our work shows, a better nasal function allows to reduce the CPAP pressure, Therefore, we believe that all patients with medium to severe obstructive apnea syndrome and for whom night-time ventilation therapy (CPAP) is advised should be evaluated with endoscopy and anamnesis oriented to evaluate nasal obstructive pathologies that may reduce effectiveness of CPAP.
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Head and Neck Cancer Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2018-2026
| Head and Neck Cancer Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2018-2026 PR Newswire (press release)Head and Neck Cancer | Market 2018 Analysis | (Dorner Conveyors, Bunting Magnetics, Eriez) and more… TheFinanceGoof (press release)Full coverage |
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Antiemetic doses of dexamethasone and their effects on immune cell populations and plasma mediators of inflammation resolution in healthy volunteers
Dexamethasone is a synthetic glucocorticoid that is widely used as an antiemetic medication in the perioperative period [1]. It is relatively inexpensive, long acting, with proven efficacy and recommended as a first line antiemetic [2]. However, in common with other glucocorticoids, dexamethasone has significant metabolic and immunological side effects. Endogenous glucocorticoids play a key function in controlling the immune response to stress, infection and injury [3]. Exogenous glucocorticoids are agents that have protean effects upon the human immune system and are widely employed in clinical practice [4]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
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Antiemetic doses of dexamethasone and their effects on immune cell populations and plasma mediators of inflammation resolution in healthy volunteers
Dexamethasone is a synthetic glucocorticoid that is widely used as an antiemetic medication in the perioperative period [1]. It is relatively inexpensive, long acting, with proven efficacy and recommended as a first line antiemetic [2]. However, in common with other glucocorticoids, dexamethasone has significant metabolic and immunological side effects. Endogenous glucocorticoids play a key function in controlling the immune response to stress, infection and injury [3]. Exogenous glucocorticoids are agents that have protean effects upon the human immune system and are widely employed in clinical practice [4]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
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Head and Neck Cancer Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2018-2026
| Head and Neck Cancer Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2018-2026 PR Newswire (press release)Global Head and Neck Cancer Drugs/Therapeutics Market Segmentation by product types, application and by ... News Egypt (press release) (blog)Full coverage |
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Head and Neck Cancer Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2018-2026
| Head and Neck Cancer Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2018-2026 PR Newswire (press release)Global Head and Neck Cancer Drugs/Therapeutics Market Segmentation by product types, application and by ... News Egypt (press release) (blog)Full coverage |
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Retrospective comparison of the number of screws used for fixation of skeletal anchorage plates in orthodontics, and their failure rates
The aim of this study was to compare the failure rate of fixation of skeletal orthodontic anchorage plates (SAP) with two screws with that of three screws, and to find out if there is a relation between the number of screws used to fix the plates and the failure rate. We reviewed clinical records of 65 patients from five hospitals with 176 SAP, and took into account other factors that may have affected the failure. The overall failure rate was 15/176 (8.5%), and for with two-screw fixation it was 9/86 compared with 6/90 for those with three-screw fixation. (Source: The British Journal of Oral and Maxillofacial Surgery)
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Star flap: new reconstructive technique for defects of the scalp
The scalp has unique challenges for surgeons, because the tissue is inelastic and thick, it is often hair bearing, and small defects can be hard to cover. We have developed a technique using four flaps for reconstruction after the excision of skin cancer, which to our knowledge has never been described before. (Source: The British Journal of Oral and Maxillofacial Surgery)
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Retrospective comparison of the number of screws used for fixation of skeletal anchorage plates in orthodontics, and their failure rates
The aim of this study was to compare the failure rate of fixation of skeletal orthodontic anchorage plates (SAP) with two screws with that of three screws, and to find out if there is a relation between the number of screws used to fix the plates and the failure rate. We reviewed clinical records of 65 patients from five hospitals with 176 SAP, and took into account other factors that may have affected the failure. The overall failure rate was 15/176 (8.5%), and for with two-screw fixation it was 9/86 compared with 6/90 for those with three-screw fixation. (Source: The British Journal of Oral and Maxillofacial Surgery)
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Depiction of the Superior Petrosal Vein Complex by 3D Contrast-Enhanced MR Angiography [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Intraoperative obliteration of the superior petrosal vein complex has a relevant risk of postoperative complications. A large venous diameter and the absence of anastomoses have been previously suggested as possible risk factors. 3D contrast-enhanced MRA was evaluated for the identification of superior petrosal vein anatomy.
MATERIALS AND METHODS:Twenty-five patients (10 men; age, 20–77 years) with a 3D-MRA (voxel size, 0.4 x 0.4 x 0.5 mm3) at 3T, including the posterior fossa, were retrospectively identified. Image evaluation was performed independently by 2 neuroradiologists with respect to overall image quality and the presence, location, size, tributaries, and anastomotic veins of the superior petrosal vein complex. Additionally, 8 neurosurgical cases with intraoperative validation of the venous anatomy were examined.
RESULTS:All studies were of diagnostic image quality. Interobserver agreement was excellent for image-quality measurements (r = 0.751–0.982) and good for measured vessel size (r = 0.563–0.828). A total of 83 superior petrosal veins were identified. The distribution of drainage locations and identification of tributaries and anastomotic veins were consistent with previous anatomic studies. The results showed that 4.8% of superior petrosal veins had a diameter of >2 mm and lacked a visible anastomosis. All surgical cases showed excellent agreement between the MRA and the intraoperative observations.
CONCLUSIONS:3D-MRA with high resolution is appropriate for analyzing the size, course, tributaries, and anastomoses of the superior petrosal vein. A total of 4.8% of the identified superior petrosal veins had to be classified as potential high-risk veins. The measurements correlated with the intraoperative findings.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qBoCCV
Synthesizing a Contrast-Enhancement Map in Patients with High-Grade Gliomas Based on a Postcontrast MR Imaging Quantification Only [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Administration of a gadolinium-based contrast agent is an important diagnostic biomarker for blood-brain barrier damage. In clinical use, detection is based on subjective comparison of native and postgadolinium-based contrast agent T1-weighted images. Quantitative MR imaging studies have suggested a relation between the longitudinal relaxation rate and proton-density in the brain parenchyma, which is disturbed by gadolinium-based contrast agents. This discrepancy can be used to synthesize a contrast-enhancement map based solely on the postgadolinium-based contrast agent acquisition. The aim of this study was to compare synthetic enhancement maps with subtraction maps of native and postgadolinium-based contrast agent images.
MATERIALS AND METHODS:For 14 patients with high-grade gliomas, quantitative MR imaging was performed before and after gadolinium-based contrast agent administration. The quantification sequence was multidynamic and multiecho, with a scan time of 6 minutes. The 2 image stacks were coregistered using in-plane transformation. The longitudinal relaxation maps were subtracted and correlated with the synthetic longitudinal relaxation enhancement maps on the basis of the postgadolinium-based contrast agent images only. ROIs were drawn for tumor delineation.
RESULTS:Linear regression of the subtraction and synthetic longitudinal relaxation enhancement maps showed a slope of 1.02 ± 0.19 and an intercept of 0.05 ± 0.12. The Pearson correlation coefficient was 0.861 ± 0.059, and the coefficient of variation was 0.18 ± 0.04. On average, a volume of 1.71 ± 1.28 mL of low-intensity enhancement was detected in the synthetic enhancement maps outside the borders of the drawn ROI.
CONCLUSIONS:The study shows that there was a good correlation between subtraction longitudinal relaxation enhancement maps and synthetic longitudinal relaxation enhancement maps in patients with high-grade gliomas. The method may improve the sensitivity and objectivity for the detection of gadolinium-based contrast agent enhancement.
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Differentiation of Hemorrhage from Iodine Using Spectral Detector CT: A Phantom Study [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Conventional CT often cannot distinguish hemorrhage from iodine extravasation following reperfusion therapy for acute ischemic stroke. We investigated the potential of spectral detector CT in differentiating these lesions.
MATERIALS AND METHODS:Centrifuged blood with increasing hematocrit (5%–85%) was used to model hemorrhage. Pure blood, blood-iodine mixtures (75/25, 50/50, and 25/75 ratios), and iodine solutions (0–14 mg I/mL) were scanned in a phantom with attenuation ranging from 12 to 75 HU on conventional imaging. Conventional and virtual noncontrast attenuation was compared and investigated for correlation with calculation of relative virtual noncontrast attenuation. Values for all investigated categories were compared using the Mann-Whitney U test. Sensitivity and specificity of virtual noncontrast, relative virtual noncontrast, conventional CT attenuation, and iodine quantification for hemorrhage detection were determined with receiver operating characteristic analysis.
RESULTS:Conventional image attenuation was not significantly different among all samples containing blood (P > .05), while virtual noncontrast attenuation showed a significant decrease with a decreasing blood component (P < .01) in all blood-iodine mixtures. Relative virtual noncontrast values were significantly different among all investigated categories (P < .01), with correct hemorrhagic component size estimation for all categories within a 95% confidence interval. Areas under the curve for hemorrhage detection were 0.97, 0.87, 0.29, and 0.16 for virtual noncontrast, relative virtual noncontrast, conventional CT attenuation, and iodine quantification, respectively. A ≥10-HU virtual noncontrast, ≥20-HU virtual noncontrast, ≥40% relative virtual noncontrast, and combined ≥10-HU virtual noncontrast and ≥40% relative virtual noncontrast attenuation threshold had a sensitivity/specificity for detecting hemorrhage of 100%/23%, 89%/95%, 100%/82%, and 100%/100%, respectively.
CONCLUSIONS:Spectral detector CT can accurately differentiate blood from iodinated contrast in a phantom setting.
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Functional MRI as an Objective Measure of Olfaction Deficit in Patients with Traumatic Anosmia [ADULT BRAIN]
BACKGROUND AND PURPOSE:
While posttraumatic anosmia is not uncommon, the olfactory function evaluation has strongly relied on subjective responses given by patients. We aimed to examine the utility of fMRI as an objective tool for diagnosing traumatic anosmia.
MATERIALS AND METHODS:Sixteen patients (11 men and 5 women; mean age, 42.2 ± 10.4 years) with clinically diagnosed traumatic anosmia and 19 healthy control subjects (11 men and 8 women; mean age, 29.3 ± 8.5 years) underwent fMRI during olfactory stimulation with citral (a pleasant odor) or β-mercaptoethanol (an unpleasant odor). All patients were subjected to a clinical olfactory functional assessment and nasal endoscopic exploration. Two-sample t tests were conducted with age as a covariate to examine group differences in brain activation responses to olfactory stimulation (false discovery rate–corrected P < .05).
RESULTS:Compared with healthy control subjects, patients with traumatic anosmia had reduced activation in the bilateral primary and secondary olfactory cortices and the limbic system in response to β-mercaptoethanol stimulation, whereas reduced activation was observed only in the left frontal subgyral region in response to citral stimulation.
CONCLUSIONS:Brain activation was decreased in the bilateral primary and secondary olfactory cortices as well as the limbic system in response to olfactory stimulation in patients with traumatic anosmia compared with healthy control subjects. These preliminary results may shed light on the potential of fMRI for the diagnosis of traumatic anosmia.
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Initial and Long-Term Outcomes of Complex Bifurcation Aneurysms Treated by Y-Stent-Assisted Coiling with Low-Profile Braided Stents [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Coiling complex intracranial bifurcation aneurysms often necessitates the implantation of double stents in various configurations, such as Y-stent placement. Low-profile braided stents have been introduced recently to facilitate the endovascular treatment of wide-neck aneurysms. We aimed to investigate the feasibility, safety, efficacy, and durability of Y-stent-assisted coiling with double low-profile braided stents for the treatment of complex bifurcation aneurysms.
MATERIALS AND METHODS:A retrospective review was performed to identify patients who were treated using Y-stent-assisted coiling with low-profile braided stents. Technical success was assessed, as were initial and follow-up clinical and angiographic outcomes. Periprocedural and delayed complications were reviewed. Preprocedural and follow-up clinical statuses were assessed using the modified Rankin Scale.
RESULTS:Forty patients with 40 intracranial aneurysms were included in the study. Y-stent placement was successfully performed in all cases. Immediate postprocedural digital subtraction angiography images revealed total aneurysm occlusion in 72.5% of cases. The mean angiographic follow-up time was 24.8 months. The last follow-up angiograms showed complete occlusion in 85% of patients. During follow-up, only 1 patient showed an increase in the filling status of the aneurysm and that patient did not require retreatment. There was no mortality in this study. The overall procedure-related complication rate, including asymptomatic complications, was 17.5%. A permanent morbidity developed in 1 patient (2.5%).
CONCLUSIONS:The long-term angiographic and clinical outcomes of this retrospective study demonstrate that Y-stent-assisted coiling using low-profile braided stents is an effective, relatively safe, and durable endovascular treatment for wide-neck and complex bifurcation aneurysms.
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How to Size Intracranial Aneurysms: A Phantom Study of Invasive and Noninvasive Methods [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Endovascular treatment of intracranial aneurysms has relevantly changed over the past decades. Multiple new devices such as intrasaccular flow diverters have broadened the treatment spectrum but require very exact aneurysm sizing. In this study, we investigated multidetector and flat panel angiographic CT and digital subtraction imaging as well as different postprocessing methods (multiplanar reconstruction, volume-rendering technique, 3D DSA, and conventional 2D angiography) for their ability to exactly size 2 aneurysm models.
MATERIALS AND METHODS:Two aneurysm models with known aneurysm sizes were placed inside a human skull. After injection of iodine contrast media, imaging was performed using a 128-slice CT scanner or an Artis Q biplane angiosuite, respectively. Aneurysms were measured for width, neck, and height, and the mean difference from the known sizes was calculated for each technique. The technique with the most exact measurement was defined as the criterion standard. We performed Bland-Altman plots comparing all techniques against the criterion standard.
RESULTS:Angiograms adjusted according a previous 3D run with a short object-to-detector distance resulted in the most exact aneurysm measurement: –0.07 ± 0.61 mm for aneurysm 1 and 0.17 ± 0.39 mm for aneurysm 2. Measurements of conventional DSA images were similar, and CT-based images were significantly inferior to the criterion standard.
CONCLUSIONS:2D DSA with a short objective-to-detector distance adjusted according to a previous 3D run resulted in the most exact aneurysm measurement and should therefore be performed before all endovascular aneurysm treatments.
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Parapharyngeal Space Venous Malformation: An Imaging Mimic of Pleomorphic Adenoma [HEAD & NECK]
SUMMARY:
Venous malformations in the parapharyngeal space are rare and may be challenging to diagnose with imaging secondary to multiple overlapping features with pleomorphic adenoma, which is much more commonly found in this region. While both lesions are T1 isointense and T2 hyperintense relative to skeletal muscle and demonstrate contrast enhancement, more uniform T2 hyperintensity and progressive contrast pooling on delayed postcontrast T1WI may allow the radiologist to include venous malformation in the differential diagnosis. This is important because it has the potential to alter management from surgical resection to observation. The primary aim of this study was to review the imaging appearance of parapharyngeal venous malformations through a retrospective case series.
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Imaging of Surgical Free Flaps in Head and Neck Reconstruction [HEAD & NECK]
SUMMARY:
Head and neck surgical reconstruction is complex, and postoperative imaging interpretation is challenging. Surgeons now use microvascular free tissue transfer, also known as free flaps, more frequently in head and neck reconstruction than ever before. Thus, an understanding of free flaps, their expected appearance on cross-sectional imaging, and their associated complications (including tumor recurrence) is crucial for the interpreting radiologist. Despite the complexity and increasing frequency of free flap reconstruction, there is no comprehensive head and neck resource intended for the radiologist. We hope that this image-rich review will fill that void and serve as a go to reference for radiologists interpreting imaging of surgical free flaps in head and neck reconstruction.
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Transdural Blood Supply in Cerebral Arteriovenous Malformations: A Systematic Evaluation of Angioarchitecture [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Arterial transdural blood supply is a rare angiographic phenomenon in cerebral AVMs. This study aimed to evaluate angiographic transdural blood supply characteristics and to describe the clinical peculiarities of these lesions.
MATERIALS AND METHODS:A prospective AVM data base of 535 patients, enrolled from 1990 to 2016, was analyzed retrospectively. Clinical information was reviewed through patients' medical charts and radiologic studies. Patients with previous AVM treatment were excluded (n = 28).
RESULTS:Patients with (n = 32, male/female ratio = 10:22; mean age, 46 ± 15 years; range, 13–75 years) and without transdural blood supply (n = 475, male/female ratio = 260:215; mean age, 40 ± 18 years; range, 2–87 years) did not show significant differences in clinical presentation (age, hemorrhage, seizures, chronic headache). The predominant nidus size in patients with transdural blood supply was ≥30 mm, with significantly more patients with large AVMs (>60 mm, P = .001). To describe the transdural blood supply, we used 3 grades based on the angiographic transdural blood supply proportion and intensity of AVM nidus perfusion (I–III). Fifty-seven percent of patients with chronic headache had a strong and substantial transdural nidus perfusion (III) and a high-flow transdural blood supply.
CONCLUSIONS:Cerebral AVMs with transdural blood supply represent a rare and heterogeneous subgroup. Lesions can be graded by quantifying the transdural blood supply of the nidus and by capturing hemodynamic characteristics. The broad spread of angiographic features and comparable clinical patterns of patients with or without transdural blood supply raises questions about the relevance of the transdural blood supply to the natural history risk of an AVM and the intention for treatment.
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Depiction of the Superior Petrosal Vein Complex by 3D Contrast-Enhanced MR Angiography [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Intraoperative obliteration of the superior petrosal vein complex has a relevant risk of postoperative complications. A large venous diameter and the absence of anastomoses have been previously suggested as possible risk factors. 3D contrast-enhanced MRA was evaluated for the identification of superior petrosal vein anatomy.
MATERIALS AND METHODS:Twenty-five patients (10 men; age, 20–77 years) with a 3D-MRA (voxel size, 0.4 x 0.4 x 0.5 mm3) at 3T, including the posterior fossa, were retrospectively identified. Image evaluation was performed independently by 2 neuroradiologists with respect to overall image quality and the presence, location, size, tributaries, and anastomotic veins of the superior petrosal vein complex. Additionally, 8 neurosurgical cases with intraoperative validation of the venous anatomy were examined.
RESULTS:All studies were of diagnostic image quality. Interobserver agreement was excellent for image-quality measurements (r = 0.751–0.982) and good for measured vessel size (r = 0.563–0.828). A total of 83 superior petrosal veins were identified. The distribution of drainage locations and identification of tributaries and anastomotic veins were consistent with previous anatomic studies. The results showed that 4.8% of superior petrosal veins had a diameter of >2 mm and lacked a visible anastomosis. All surgical cases showed excellent agreement between the MRA and the intraoperative observations.
CONCLUSIONS:3D-MRA with high resolution is appropriate for analyzing the size, course, tributaries, and anastomoses of the superior petrosal vein. A total of 4.8% of the identified superior petrosal veins had to be classified as potential high-risk veins. The measurements correlated with the intraoperative findings.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qBoCCV
Synthesizing a Contrast-Enhancement Map in Patients with High-Grade Gliomas Based on a Postcontrast MR Imaging Quantification Only [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Administration of a gadolinium-based contrast agent is an important diagnostic biomarker for blood-brain barrier damage. In clinical use, detection is based on subjective comparison of native and postgadolinium-based contrast agent T1-weighted images. Quantitative MR imaging studies have suggested a relation between the longitudinal relaxation rate and proton-density in the brain parenchyma, which is disturbed by gadolinium-based contrast agents. This discrepancy can be used to synthesize a contrast-enhancement map based solely on the postgadolinium-based contrast agent acquisition. The aim of this study was to compare synthetic enhancement maps with subtraction maps of native and postgadolinium-based contrast agent images.
MATERIALS AND METHODS:For 14 patients with high-grade gliomas, quantitative MR imaging was performed before and after gadolinium-based contrast agent administration. The quantification sequence was multidynamic and multiecho, with a scan time of 6 minutes. The 2 image stacks were coregistered using in-plane transformation. The longitudinal relaxation maps were subtracted and correlated with the synthetic longitudinal relaxation enhancement maps on the basis of the postgadolinium-based contrast agent images only. ROIs were drawn for tumor delineation.
RESULTS:Linear regression of the subtraction and synthetic longitudinal relaxation enhancement maps showed a slope of 1.02 ± 0.19 and an intercept of 0.05 ± 0.12. The Pearson correlation coefficient was 0.861 ± 0.059, and the coefficient of variation was 0.18 ± 0.04. On average, a volume of 1.71 ± 1.28 mL of low-intensity enhancement was detected in the synthetic enhancement maps outside the borders of the drawn ROI.
CONCLUSIONS:The study shows that there was a good correlation between subtraction longitudinal relaxation enhancement maps and synthetic longitudinal relaxation enhancement maps in patients with high-grade gliomas. The method may improve the sensitivity and objectivity for the detection of gadolinium-based contrast agent enhancement.
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Brain MR Imaging Findings in Woodhouse-Sakati Syndrome [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Woodhouse-Sakati syndrome is a rare autosomal recessive disorder characterized by hypogonadism, alopecia, diabetes mellitus, and progressive extrapyramidal signs. The disease is caused by biallelic pathogenic variants in the DCAF17 gene. The purpose of this study was to describe the spectrum of brain MR imaging abnormalities in Woodhouse-Sakati syndrome.
MATERIALS AND METHODS:We reviewed brain MR images of 26 patients with a clinical and genetic diagnosis of Woodhouse-Sakati syndrome (12 males, 14 females; age range, 16–45 years; mean age, 26.6 years). Follow-up studies were conducted for 6 patients.
RESULTS:All patients had abnormal MR imaging findings. The most common abnormalities were a small pituitary gland (76.9%), pronounced basal ganglia iron deposition (73%), and white matter lesions in 69.2%. White matter lesions showed frontoparietal and periventricular predominance. All white matter lesions spared subcortical U-fibers and were nonenhanced. Prominent perivascular spaces (15.3%) and restricted diffusion in the splenium of the corpus callosum (7.6%) were less frequent findings. Follow-up studies showed expansion of white matter lesions with iron deposition further involving the red nucleus and substantia nigra. Older age was associated with a more severe degree of white matter lesions (P < .001).
CONCLUSIONS:Small pituitary gland, accentuated iron deposition in the globus pallidus, and nonenhancing frontoparietal/periventricular white matter lesions were the most noted abnormalities seen in our cohort. The pattern and extent of these findings were observed to correlate with older age, reflecting a possible progressive myelin destruction and/or axonal loss. The presence of pituitary hypoplasia and white matter lesions can further distinguish Woodhouse-Sakati syndrome from other neurodegenerative diseases with brain iron accumulation subtypes.
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Functional MRI as an Objective Measure of Olfaction Deficit in Patients with Traumatic Anosmia [ADULT BRAIN]
BACKGROUND AND PURPOSE:
While posttraumatic anosmia is not uncommon, the olfactory function evaluation has strongly relied on subjective responses given by patients. We aimed to examine the utility of fMRI as an objective tool for diagnosing traumatic anosmia.
MATERIALS AND METHODS:Sixteen patients (11 men and 5 women; mean age, 42.2 ± 10.4 years) with clinically diagnosed traumatic anosmia and 19 healthy control subjects (11 men and 8 women; mean age, 29.3 ± 8.5 years) underwent fMRI during olfactory stimulation with citral (a pleasant odor) or β-mercaptoethanol (an unpleasant odor). All patients were subjected to a clinical olfactory functional assessment and nasal endoscopic exploration. Two-sample t tests were conducted with age as a covariate to examine group differences in brain activation responses to olfactory stimulation (false discovery rate–corrected P < .05).
RESULTS:Compared with healthy control subjects, patients with traumatic anosmia had reduced activation in the bilateral primary and secondary olfactory cortices and the limbic system in response to β-mercaptoethanol stimulation, whereas reduced activation was observed only in the left frontal subgyral region in response to citral stimulation.
CONCLUSIONS:Brain activation was decreased in the bilateral primary and secondary olfactory cortices as well as the limbic system in response to olfactory stimulation in patients with traumatic anosmia compared with healthy control subjects. These preliminary results may shed light on the potential of fMRI for the diagnosis of traumatic anosmia.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qDuP1o
Initial and Long-Term Outcomes of Complex Bifurcation Aneurysms Treated by Y-Stent-Assisted Coiling with Low-Profile Braided Stents [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Coiling complex intracranial bifurcation aneurysms often necessitates the implantation of double stents in various configurations, such as Y-stent placement. Low-profile braided stents have been introduced recently to facilitate the endovascular treatment of wide-neck aneurysms. We aimed to investigate the feasibility, safety, efficacy, and durability of Y-stent-assisted coiling with double low-profile braided stents for the treatment of complex bifurcation aneurysms.
MATERIALS AND METHODS:A retrospective review was performed to identify patients who were treated using Y-stent-assisted coiling with low-profile braided stents. Technical success was assessed, as were initial and follow-up clinical and angiographic outcomes. Periprocedural and delayed complications were reviewed. Preprocedural and follow-up clinical statuses were assessed using the modified Rankin Scale.
RESULTS:Forty patients with 40 intracranial aneurysms were included in the study. Y-stent placement was successfully performed in all cases. Immediate postprocedural digital subtraction angiography images revealed total aneurysm occlusion in 72.5% of cases. The mean angiographic follow-up time was 24.8 months. The last follow-up angiograms showed complete occlusion in 85% of patients. During follow-up, only 1 patient showed an increase in the filling status of the aneurysm and that patient did not require retreatment. There was no mortality in this study. The overall procedure-related complication rate, including asymptomatic complications, was 17.5%. A permanent morbidity developed in 1 patient (2.5%).
CONCLUSIONS:The long-term angiographic and clinical outcomes of this retrospective study demonstrate that Y-stent-assisted coiling using low-profile braided stents is an effective, relatively safe, and durable endovascular treatment for wide-neck and complex bifurcation aneurysms.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FbWBff
How to Size Intracranial Aneurysms: A Phantom Study of Invasive and Noninvasive Methods [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Endovascular treatment of intracranial aneurysms has relevantly changed over the past decades. Multiple new devices such as intrasaccular flow diverters have broadened the treatment spectrum but require very exact aneurysm sizing. In this study, we investigated multidetector and flat panel angiographic CT and digital subtraction imaging as well as different postprocessing methods (multiplanar reconstruction, volume-rendering technique, 3D DSA, and conventional 2D angiography) for their ability to exactly size 2 aneurysm models.
MATERIALS AND METHODS:Two aneurysm models with known aneurysm sizes were placed inside a human skull. After injection of iodine contrast media, imaging was performed using a 128-slice CT scanner or an Artis Q biplane angiosuite, respectively. Aneurysms were measured for width, neck, and height, and the mean difference from the known sizes was calculated for each technique. The technique with the most exact measurement was defined as the criterion standard. We performed Bland-Altman plots comparing all techniques against the criterion standard.
RESULTS:Angiograms adjusted according a previous 3D run with a short object-to-detector distance resulted in the most exact aneurysm measurement: –0.07 ± 0.61 mm for aneurysm 1 and 0.17 ± 0.39 mm for aneurysm 2. Measurements of conventional DSA images were similar, and CT-based images were significantly inferior to the criterion standard.
CONCLUSIONS:2D DSA with a short objective-to-detector distance adjusted according to a previous 3D run resulted in the most exact aneurysm measurement and should therefore be performed before all endovascular aneurysm treatments.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qAUN5t
Parapharyngeal Space Venous Malformation: An Imaging Mimic of Pleomorphic Adenoma [HEAD & NECK]
SUMMARY:
Venous malformations in the parapharyngeal space are rare and may be challenging to diagnose with imaging secondary to multiple overlapping features with pleomorphic adenoma, which is much more commonly found in this region. While both lesions are T1 isointense and T2 hyperintense relative to skeletal muscle and demonstrate contrast enhancement, more uniform T2 hyperintensity and progressive contrast pooling on delayed postcontrast T1WI may allow the radiologist to include venous malformation in the differential diagnosis. This is important because it has the potential to alter management from surgical resection to observation. The primary aim of this study was to review the imaging appearance of parapharyngeal venous malformations through a retrospective case series.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FehKpg
Imaging of Surgical Free Flaps in Head and Neck Reconstruction [HEAD & NECK]
SUMMARY:
Head and neck surgical reconstruction is complex, and postoperative imaging interpretation is challenging. Surgeons now use microvascular free tissue transfer, also known as free flaps, more frequently in head and neck reconstruction than ever before. Thus, an understanding of free flaps, their expected appearance on cross-sectional imaging, and their associated complications (including tumor recurrence) is crucial for the interpreting radiologist. Despite the complexity and increasing frequency of free flap reconstruction, there is no comprehensive head and neck resource intended for the radiologist. We hope that this image-rich review will fill that void and serve as a go to reference for radiologists interpreting imaging of surgical free flaps in head and neck reconstruction.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qAUO9x
Transdural Blood Supply in Cerebral Arteriovenous Malformations: A Systematic Evaluation of Angioarchitecture [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Arterial transdural blood supply is a rare angiographic phenomenon in cerebral AVMs. This study aimed to evaluate angiographic transdural blood supply characteristics and to describe the clinical peculiarities of these lesions.
MATERIALS AND METHODS:A prospective AVM data base of 535 patients, enrolled from 1990 to 2016, was analyzed retrospectively. Clinical information was reviewed through patients' medical charts and radiologic studies. Patients with previous AVM treatment were excluded (n = 28).
RESULTS:Patients with (n = 32, male/female ratio = 10:22; mean age, 46 ± 15 years; range, 13–75 years) and without transdural blood supply (n = 475, male/female ratio = 260:215; mean age, 40 ± 18 years; range, 2–87 years) did not show significant differences in clinical presentation (age, hemorrhage, seizures, chronic headache). The predominant nidus size in patients with transdural blood supply was ≥30 mm, with significantly more patients with large AVMs (>60 mm, P = .001). To describe the transdural blood supply, we used 3 grades based on the angiographic transdural blood supply proportion and intensity of AVM nidus perfusion (I–III). Fifty-seven percent of patients with chronic headache had a strong and substantial transdural nidus perfusion (III) and a high-flow transdural blood supply.
CONCLUSIONS:Cerebral AVMs with transdural blood supply represent a rare and heterogeneous subgroup. Lesions can be graded by quantifying the transdural blood supply of the nidus and by capturing hemodynamic characteristics. The broad spread of angiographic features and comparable clinical patterns of patients with or without transdural blood supply raises questions about the relevance of the transdural blood supply to the natural history risk of an AVM and the intention for treatment.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2F7RcpA
Issues and Findings in Common Cavity Deformity
This narrative review describes the various aspects of common cavity deformity and examines cochlear implant, the first-line option for achieving hearing function in patients with common cavity deformity. (Source: JAMA Otolaryngology - Head and Neck Surgery)
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News: Introducing First Look, a preview of NeuroImage: Clinical papers under review
First Look makes papers discoverable earlier in the publication process, so authors can reveal their research quickly and readers can build on their work.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qw4Iom
News: Introducing First Look, a preview of NeuroImage: Clinical papers under review
First Look makes papers discoverable earlier in the publication process, so authors can reveal their research quickly and readers can build on their work.
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A Co-culture Model of PBMC and Stem Cell Derived Human Nasal Epithelium Reveals Rapid Activation of NK and Innate T Cells Upon Influenza A Virus Infection of the Nasal Epithelium
Annika Luukkainen, Kia Joo Puan, Nurhashikin Yusof, Bernett Lee, Kai Sen Tan, Jing Liu, Yan Yan, Sanna Toppila-Salmi, Risto Renkonen, Vincent T. Chow, Olaf Rotzschke, De Yun Wang (Source: Frontiers in Immunology)
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The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens
Neil A. Mabbott (Source: Frontiers in Immunology)
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TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation
Early exposure to inflammatory signals may have a lasting impact on immune function. Present throughout embryogenesis, macrophages are key cells providing innate immune protection to the developing fetus and newborn. Here, we have used an established model of macrophage development to test how early inflammatory signals can impact cellular differentiation and function. Bone marrow-derived macrophages were treated withEscherichia coli lipopolysaccharide (LPS) 2 days after initial isolation and culture. LPS treatment during this early stage of differentiation decreased the expression of CSF1R and increased that of the mature macrophage marker F4/80. These early changes in macrophage differentiation were also measured in cells from mice lacking IKK β, but the change in CSF1R expression after...
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Effect of age on NK cell compartment in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Paulo Rodrigues-Santos, Nelson L ópez Sejas, JaniSofia Almeida, Lenka Ruzičková, Patricia Couceiro, Vera Alves, Carmen Campos, Corona Alonso, Raquel Tarazona, Paulo Freitas-Tavares, Rafael Solana, Manuel Santos Rosa (Source: Frontiers in Immunology)
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Immune activation and regulatory T cells in Mycobacterium tuberculosis infected lymph nodes
Lymph node tuberculosis (LNTB) is the most frequent extrapulmonary form of tuberculosis (TB). Studies of human tuberculosis at sites of disease are limited. LNTB provides a unique opportunity to compare local in ... (Source: BMC Immunology)
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Low dose provocation and skin tests in patients with hypersensitivity to Gadolinium ‐based contrast agents
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
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Sweet syndrome: a rare feature of ANCA-associated vasculitis or unusual consequence of azathioprine-induced treatment
Sweet syndrome is a rare skin condition characterised by fever, neutrophilia, and tender erythematous skin lesions and has been reported to occur in association with anti-neutrophil cytoplasmic antibodies (ANC... (Source: Allergy, Asthma and Clinical Immunology)
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Component resolved analysis of ash pollen allergy in Bavaria
Sensitization to ash pollen is underestimated in various regions. The prevalence in Germany is about 10%. However, allergy to ash pollen is widely overlooked by allergists, since the pollination period of ash ... (Source: Allergy, Asthma and Clinical Immunology)
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The Basophil Activation Test reduces the need for a food challenge test in children suspected of IgE‐mediated cow's milk allergy
Abstract
Background
The gold standard for the diagnosis of cow's milk allergy is the Double‐Blind Placebo‐Controlled Food Challenge (DBPCFC) test. However, disadvantages of the DBPCFC are the potential risk of anaphylactic reactions, the time consuming procedure and high costs.
Objective
The aim of this study is to determine the reliability of the Basophil Activation Test (BAT) both for the initial diagnosis of cow's milk allergy in children and for determination of tolerance in children with cow's milk allergy.
Methods
97 BATs and cow's milk specific IgE (sIgE) tests were performed in 86 infants/young children, suspected of (persistent) cow's milk allergy, who were qualified for an in‐hospital DBPCFC. The BAT was performed with cow's milk extract and the purified major allergens casein, α‐lactalbumin, β‐lactoglubulin. Basophil activation was determined by CD63 up‐regulation measured by flow cytometry. The BAT results were compared to the DBPCFC outcomes.
Results
Based on unequivocal DBPCFC and BAT result combinations (80%), the BAT had a sensitivity and specificity of 100% (CI 86‐100% and 68‐100%, respectively) in IgE sensitized children (41% of the tested children). All non‐IgE sensitized children (59%) had a negative DBPCFC and BAT, except for five patients. These latter showed delayed and relatively mild symptoms in the DBPCFC with a negative BAT, supporting a non‐IgE mediated allergy in these children.
Conclusions and Clinical Relevance
The BAT seems reliable and cost‐effective to diagnose patients with an IgE‐mediated cow's milk allergy. In IgE sensitized patients a BAT might replace a DBPCFC. For non‐IgE sensitized patients presenting with mild symptoms we propose to consider a (double‐blind) extended (time) challenge test at home.
This article is protected by copyright. All rights reserved.
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The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens
Neil A. Mabbott (Source: Frontiers in Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PiBMDv
TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation
Early exposure to inflammatory signals may have a lasting impact on immune function. Present throughout embryogenesis, macrophages are key cells providing innate immune protection to the developing fetus and newborn. Here, we have used an established model of macrophage development to test how early inflammatory signals can impact cellular differentiation and function. Bone marrow-derived macrophages were treated withEscherichia coli lipopolysaccharide (LPS) 2 days after initial isolation and culture. LPS treatment during this early stage of differentiation decreased the expression of CSF1R and increased that of the mature macrophage marker F4/80. These early changes in macrophage differentiation were also measured in cells from mice lacking IKK β, but the change in CSF1R expression after...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QC3kjO
Effect of age on NK cell compartment in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Paulo Rodrigues-Santos, Nelson L ópez Sejas, JaniSofia Almeida, Lenka Ruzičková, Patricia Couceiro, Vera Alves, Carmen Campos, Corona Alonso, Raquel Tarazona, Paulo Freitas-Tavares, Rafael Solana, Manuel Santos Rosa (Source: Frontiers in Immunology)
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Immune activation and regulatory T cells in Mycobacterium tuberculosis infected lymph nodes
Lymph node tuberculosis (LNTB) is the most frequent extrapulmonary form of tuberculosis (TB). Studies of human tuberculosis at sites of disease are limited. LNTB provides a unique opportunity to compare local in ... (Source: BMC Immunology)
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Low dose provocation and skin tests in patients with hypersensitivity to Gadolinium ‐based contrast agents
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
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Lung –infiltrating T helper 17 cells as the major source of interleukin-17A production during pulmonary Cryptococcus neoformans infection
In this study, we aim to elucidate the activity of IL-17... (Source: BMC Immunology)
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The utility of anti-SOX2 antibodies for cancer prediction in patients with paraneoplastic neurological disorders
Antibodies to SOXB1 proteins in patients with paraneoplastic disorders are associated with small-cell lung cancer (SCLC), particularly in Lambert-Eaton myasthenic syndrome (LEMS). We aimed to establish if SOX2 antibodies could be used to identify SCLC and other tumours found in a range of paraneoplastic disorders and controls.SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC. (Source: Journal of Neuroimmunology)
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Aetiology of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka
The aetiology of anaphylaxis differs according to types of foods consumed, fauna and foliage and cultural practices. Although the aetiology of anaphylaxis in Western countries are well known, the causes in Sou... (Source: Allergy, Asthma and Clinical Immunology)
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Sweet syndrome: a rare feature of ANCA-associated vasculitis or unusual consequence of azathioprine-induced treatment
Sweet syndrome is a rare skin condition characterised by fever, neutrophilia, and tender erythematous skin lesions and has been reported to occur in association with anti-neutrophil cytoplasmic antibodies (ANC... (Source: Allergy, Asthma and Clinical Immunology)
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Component resolved analysis of ash pollen allergy in Bavaria
Sensitization to ash pollen is underestimated in various regions. The prevalence in Germany is about 10%. However, allergy to ash pollen is widely overlooked by allergists, since the pollination period of ash ... (Source: Allergy, Asthma and Clinical Immunology)
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Veracyte Announces Publication of Data Demonstrating “Real World” Performance of Afirma GSC in Thyroid Cancer ...
| Veracyte Announces Publication of Data Demonstrating "Real World" Performance of Afirma GSC in Thyroid Cancer ... Watertown Public OpinionFull coverage |
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Primatene Mist Returns After 7-Year Absence
(MedPage Today) -- Reformulated asthma inhaler OK'd for over-the-counter sale (Source: MedPage Today Allergy)
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Sanofi and Regeneron's Dupixent Gets More Positive Feedback From U.S. FDA Sanofi and Regeneron's Dupixent Gets More Positive Feedback From U.S. FDA
The U.S. Food& Drug Administration (FDA) regulator has given more positive feedback on the Dupixent eczema treatment being developed by drugmakers Sanofi and Regeneron, the companies said on Tuesday.Reuters Health Information (Source: Medscape Allergy Headlines)
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U.S. Marine Families Battle Mice, Mold and Landlords U.S. Marine Families Battle Mice, Mold and Landlords
When Matt Limon enlisted in the U.S. Marines, he and wife Sharon were prepared to make sacrifices for their country: faraway deployments, long absences and frequent moves for a family with two young children.Reuters Health Information (Source: Medscape Allergy Headlines)
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Innate immune crosstalk in asthmatic airways: innate lymphoid cells coordinate the polarization of lung macrophage
Increased numbers of all types of ILCs, including ILC2s, were observed in induced sputum of asthma patients when compared with healthy controls. ILCs affect the polarization of macrophages and contribute to the development of different phenotypes of asthma. (Source: Journal of Allergy and Clinical Immunology)
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Peak Flow Variability In Childhood And Body Mass Index In Adult Life
Peak flow variability in childhood is a significant and independent predictor of subsequent body mass index increase up to age 26. Shared developmental and genetic factors may explain, at least in part, the association between these two phenotypes. (Source: Journal of Allergy and Clinical Immunology)
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Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation
Ceramide-CD300f binding inhibits mouse Mrgprb2 (human MrgprX2)-mediated mast cell activation, thereby suppressing pseudo-allergic reactions. CD300f could be a therapeutic target against IgE-independent pseudo-allergy as well as IgE-dependent allergy. (Source: Journal of Allergy and Clinical Immunology)
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Eosinophil progenitor levels correlate with tissue pathology in pediatric eosinophilic esophagitis
Blood eosinophil progenitors (EoPs) correlate with tissue pathology during active eosinophilic esophagitis (EoE), providing additional evidence for blood EoP levels as a biomarker for disease activity and suggesting a role for EoPs in EoE pathogenesis. (Source: Journal of Allergy and Clinical Immunology)
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New delivery forms of nasal corticosteroids
(Source: Journal of Allergy and Clinical Immunology)
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Efficacy and safety of histamine H4 receptor antagonist ZPL-3893787 in atopic dermatitis
ZPL-3893787, a selective H4 receptor antagonist, has a clinically significant anti-inflammatory effect in moderate to severe AD in humans upon oral administration over a period of 8 weeks. (Source: Journal of Allergy and Clinical Immunology)
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Engineering of structural variants of the major peanut allergens Ara h 2 and Ara h 6 for allergen-specific immunotherapy
Applying a novel way to design hypoallergens, we produced variants of the major peanut allergens Ara h 2 and Ara h 6 with significantly reduced IgE-binding and basophil activation capacities and preserved T-cell stimulatory activity. (Source: Journal of Allergy and Clinical Immunology)
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Novel locus for atopic dermatitis in African Americans and replication in European Americans
The present study provides the first genetic locus associated with AD in African Americans. (Source: Journal of Allergy and Clinical Immunology)
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Sanofi and Regeneron's Dupixent Gets More Positive Feedback From U.S. FDA Sanofi and Regeneron's Dupixent Gets More Positive Feedback From U.S. FDA
The U.S. Food& Drug Administration (FDA) regulator has given more positive feedback on the Dupixent eczema treatment being developed by drugmakers Sanofi and Regeneron, the companies said on Tuesday.Reuters Health Information (Source: Medscape Allergy Headlines)
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Many Women Over 50 Have Urinary Incontinence, Most Don't Seek Treatment Many Women Over 50 Have Urinary Incontinence, Most Don't Seek Treatment
Nearly half of women over age 50 report bladder leakage and many say it's a major problem for them, according to a new U.S. survey.Reuters Health Information (Source: Medscape Allergy Headlines)
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U.S. Marine Families Battle Mice, Mold and Landlords U.S. Marine Families Battle Mice, Mold and Landlords
When Matt Limon enlisted in the U.S. Marines, he and wife Sharon were prepared to make sacrifices for their country: faraway deployments, long absences and frequent moves for a family with two young children.Reuters Health Information (Source: Medscape Allergy Headlines)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DpzeNE
Innate immune crosstalk in asthmatic airways: innate lymphoid cells coordinate the polarization of lung macrophage
Increased numbers of all types of ILCs, including ILC2s, were observed in induced sputum of asthma patients when compared with healthy controls. ILCs affect the polarization of macrophages and contribute to the development of different phenotypes of asthma. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2REIf8C
Peak Flow Variability In Childhood And Body Mass Index In Adult Life
Peak flow variability in childhood is a significant and independent predictor of subsequent body mass index increase up to age 26. Shared developmental and genetic factors may explain, at least in part, the association between these two phenotypes. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yXXgvy
Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation
Ceramide-CD300f binding inhibits mouse Mrgprb2 (human MrgprX2)-mediated mast cell activation, thereby suppressing pseudo-allergic reactions. CD300f could be a therapeutic target against IgE-independent pseudo-allergy as well as IgE-dependent allergy. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2REpgv0
Eosinophil progenitor levels correlate with tissue pathology in pediatric eosinophilic esophagitis
Blood eosinophil progenitors (EoPs) correlate with tissue pathology during active eosinophilic esophagitis (EoE), providing additional evidence for blood EoP levels as a biomarker for disease activity and suggesting a role for EoPs in EoE pathogenesis. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z0T3Hv
New delivery forms of nasal corticosteroids
(Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RJXT2u
Efficacy and safety of histamine H4 receptor antagonist ZPL-3893787 in atopic dermatitis
ZPL-3893787, a selective H4 receptor antagonist, has a clinically significant anti-inflammatory effect in moderate to severe AD in humans upon oral administration over a period of 8 weeks. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z2uoSH
Engineering of structural variants of the major peanut allergens Ara h 2 and Ara h 6 for allergen-specific immunotherapy
Applying a novel way to design hypoallergens, we produced variants of the major peanut allergens Ara h 2 and Ara h 6 with significantly reduced IgE-binding and basophil activation capacities and preserved T-cell stimulatory activity. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RKxFgq
Novel locus for atopic dermatitis in African Americans and replication in European Americans
The present study provides the first genetic locus associated with AD in African Americans. (Source: Journal of Allergy and Clinical Immunology)
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Identification of Pen m 4 as a potential cause of occupational asthma to Gammarus shrimp
Abstract
We present the case of a 34-year-old male patient employed for 8 years in a company manufacturing and packaging animal feed. The patient developed occupational asthma to dry Gammarus powder. The diagnosis was confirmed by specific bronchial provocation test. The determination of specific IgE antibodies was positive for Pen m 4, a sarcoplasmic calcium binding protein, with a level of 6.7 ISU-E. The sensitization to Pen m 4 described here may identify a new allergen causing occupational asthma in these workers.
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Identification of Pen m 4 as a potential cause of occupational asthma to Gammarus shrimp
Abstract
We present the case of a 34-year-old male patient employed for 8 years in a company manufacturing and packaging animal feed. The patient developed occupational asthma to dry Gammarus powder. The diagnosis was confirmed by specific bronchial provocation test. The determination of specific IgE antibodies was positive for Pen m 4, a sarcoplasmic calcium binding protein, with a level of 6.7 ISU-E. The sensitization to Pen m 4 described here may identify a new allergen causing occupational asthma in these workers.
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Seltene Differenzialdiagnose einer Tonsillopharyngitis
Laryngo-Rhino-Otol
DOI: 10.1055/a-0762-4033
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
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Endogenous nerve growth factor stimulation: effects on auditory pathway neural cells in a mouse model.
CONCLUSIONS: This treatment can significantly protect and/or delay degeneration of cochlear auditory NGF-target cells. It is free from side effects and can be used in chronic diseases for as long as needed. It remains to be investigated whether the effects of short-term therapy are long-lasting, or if the treatment must be repeated. PMID: 30402868 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
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Sensorimotor characteristics of sign translations modulate EEG when deaf signers read English.
Authors: Quandt LC, Kubicek E Abstract Bilingual individuals automatically translate written words from one language to another. While this process is established in spoken-language bilinguals, there is less known about its occurrence in deaf bilinguals who know signed and spoken languages. Since sign language uses motion and space to convey linguistic content, it is possible that action simulation in the brain's sensorimotor system plays a role in this process. We recorded EEG from deaf participants fluent in ASL as they read individual English words and found significant differences in alpha and beta EEG at central electrode sites during the reading of English words whose ASL translations use two hands, compared to English words whose ASL translations use one hand. Hearing non-si...
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Seltene Differenzialdiagnose einer Tonsillopharyngitis
Laryngo-Rhino-Otol
DOI: 10.1055/a-0762-4033
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OwLcpP
Endogenous nerve growth factor stimulation: effects on auditory pathway neural cells in a mouse model.
CONCLUSIONS: This treatment can significantly protect and/or delay degeneration of cochlear auditory NGF-target cells. It is free from side effects and can be used in chronic diseases for as long as needed. It remains to be investigated whether the effects of short-term therapy are long-lasting, or if the treatment must be repeated. PMID: 30402868 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z0GdZv
Sensorimotor characteristics of sign translations modulate EEG when deaf signers read English.
Authors: Quandt LC, Kubicek E Abstract Bilingual individuals automatically translate written words from one language to another. While this process is established in spoken-language bilinguals, there is less known about its occurrence in deaf bilinguals who know signed and spoken languages. Since sign language uses motion and space to convey linguistic content, it is possible that action simulation in the brain's sensorimotor system plays a role in this process. We recorded EEG from deaf participants fluent in ASL as they read individual English words and found significant differences in alpha and beta EEG at central electrode sites during the reading of English words whose ASL translations use two hands, compared to English words whose ASL translations use one hand. Hearing non-si...
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Effect of a multistrain probiotic (Lactoflorene® Plus) on inflammatory parameters and microbiota composition in subjects with stress-related symptoms
Publication date: Available online 7 November 2018Source: Neurobiology of StressAuthor(s): Sara Soldi, Sara Carlotta Tagliacarne, Chiara Valsecchi, Simone Perna, Mariangela Rondanelli, Luigi Ziviani, Stefano Milleri, Ariella Annoni, Annamaria CastellazziAbstractStress affects the immune system and intestinal microbiota composition and can lead to imbalance between pro- and anti-inflammatory cytokines or to uncontrolled production of cytokines. The effect of emotional stress on secretory IgA levels also indicates that stress decreases mucosal integrity. Our aim was to evaluate whether a probiotic product (Lactoflorene® Plus) can prevent alterations in the immune response associated with self-reported stress and microbiota composition. Healthy adult volunteers who self-reported psychologica...
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Inflammatory biomarkers in psychosis and clinical high risk populations
In this study we investigated potential contributing inflammatory mechanisms for IL-6 elevation. (Source: Schizophrenia Research)
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Look for early signs of thyroid cancer, experts urge
| Look for early signs of thyroid cancer, experts urge Health24Full coverage |
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Effect of a multistrain probiotic (Lactoflorene® Plus) on inflammatory parameters and microbiota composition in subjects with stress-related symptoms
Publication date: Available online 7 November 2018Source: Neurobiology of StressAuthor(s): Sara Soldi, Sara Carlotta Tagliacarne, Chiara Valsecchi, Simone Perna, Mariangela Rondanelli, Luigi Ziviani, Stefano Milleri, Ariella Annoni, Annamaria CastellazziAbstractStress affects the immune system and intestinal microbiota composition and can lead to imbalance between pro- and anti-inflammatory cytokines or to uncontrolled production of cytokines. The effect of emotional stress on secretory IgA levels also indicates that stress decreases mucosal integrity. Our aim was to evaluate whether a probiotic product (Lactoflorene® Plus) can prevent alterations in the immune response associated with self-reported stress and microbiota composition. Healthy adult volunteers who self-reported psychologica...
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Inflammatory biomarkers in psychosis and clinical high risk populations
In this study we investigated potential contributing inflammatory mechanisms for IL-6 elevation. (Source: Schizophrenia Research)
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Look for early signs of thyroid cancer, experts urge
| Look for early signs of thyroid cancer, experts urge Health24Full coverage |
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OuMjq8
Nationwide survey of congenital cholesteatoma using staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society
This study was undertaken to determine the characteristics of congenital cholesteatoma (CC) in Japan, via a nationwide survey using staging and classification criteria for middle ear cholesteatoma, as proposed by the Japan Otological Society (JOS).
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Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970–99: a report ...
| Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970–99: a report ... The LancetFull coverage |
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