Evaluation of the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw

Abstract

Objective

The aim of this study was to evaluate the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw (MRONJ).

Materials and methods

To induce MRONJ, a total of 120 rats received intravenous zoledronate 0.06 mg/kg once a week for 6 weeks and their right mandibular first molar was extracted. Eighty of 94 rats with MRONJ were randomly selected and underwent unilateral mandibular osteotomy to replicate a fracture. After surgery, the rats were randomly assigned to T (teriparatide-treated) and C (control) groups. Group T (n = 40) received subcutaneous injection of 2 μg/kg/day teriparatide and group C (n = 40) received the same volume of normal saline until sacrifice. Four and 8 weeks after surgery, 20 rats in each group were sacrificed. Fracture healing was scored using a histological grading system (1 to 10).

Results

In group C, at 4 weeks and 8 weeks post-fracture, fibrous and cartilaginous tissues and scant bone formation at the fracture site and lacunae without osteocyte in adjacent mandibular bone were seen. In group T, substantial amounts of new trabecular bone rimmed by osteoblasts and some areas of remodeled mature bone were seen. After 8 weeks, extensive replacement of trabecular bone with mature bone occurred. Except between C4 and C8 groups, the healing score was significantly different between all subgroups.

Conclusion

Teriparatide therapy successfully improved mandibular fracture healing in rats with MRONJ. However, this study was limited by the use of an animal model whose anatomy, physiology, and drug metabolism might be different from humans.

Clinical relevance

The present study showed that teriparatide therapy may be used adjunctive to surgery in the treatment of mandibular fractures in MRONJ patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MN1sDU

Evaluation of the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw

Abstract

Objective

The aim of this study was to evaluate the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw (MRONJ).

Materials and methods

To induce MRONJ, a total of 120 rats received intravenous zoledronate 0.06 mg/kg once a week for 6 weeks and their right mandibular first molar was extracted. Eighty of 94 rats with MRONJ were randomly selected and underwent unilateral mandibular osteotomy to replicate a fracture. After surgery, the rats were randomly assigned to T (teriparatide-treated) and C (control) groups. Group T (n = 40) received subcutaneous injection of 2 μg/kg/day teriparatide and group C (n = 40) received the same volume of normal saline until sacrifice. Four and 8 weeks after surgery, 20 rats in each group were sacrificed. Fracture healing was scored using a histological grading system (1 to 10).

Results

In group C, at 4 weeks and 8 weeks post-fracture, fibrous and cartilaginous tissues and scant bone formation at the fracture site and lacunae without osteocyte in adjacent mandibular bone were seen. In group T, substantial amounts of new trabecular bone rimmed by osteoblasts and some areas of remodeled mature bone were seen. After 8 weeks, extensive replacement of trabecular bone with mature bone occurred. Except between C4 and C8 groups, the healing score was significantly different between all subgroups.

Conclusion

Teriparatide therapy successfully improved mandibular fracture healing in rats with MRONJ. However, this study was limited by the use of an animal model whose anatomy, physiology, and drug metabolism might be different from humans.

Clinical relevance

The present study showed that teriparatide therapy may be used adjunctive to surgery in the treatment of mandibular fractures in MRONJ patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MN1sDU

Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population

Conditions:   Hepatitis E;   Immunisation Interventions:   Biological: HEV 239;   Other: Placebo Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UCBTZ1

Allergy UK Research and Development Nurse Project

Condition:   Allergy Intervention:   Other: Nurse Led Allergy Clinic Sponsors:   University of Edinburgh;   Allergy UK Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SaN0M3

Retrospective Chart Review of Candida Fungemia

Condition:   Candida Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UxRYiu

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Conditions:   Pulmonary Invasive Mold Infections;   Pulmonary Invasive Aspergillosis Intervention:   Diagnostic Test: Non-Invasive Testing for PIMI Sponsors:   Duke University;   Children's Hospital of Philadelphia;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S9Xv2a

Food Allergen Eliminations and Combined Protocols for Obesity Reduction: a Preliminary Comparison Study

Condition:   Obesity Intervention:   Behavioral: Food Allergy Elimination + Willis Exercise Sponsor:   Galveston Clinical Research Foundation Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UCBSEr

AQUApay (AQUA Predictive Ability in Youths): Study on the Predictive Ability of the Questionnaire AQUA © in Children and Adolescents

Condition:   Young Athletes Intervention:   Diagnostic Test: Questionnaire AQUA©, pediatric version Sponsor:   Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S7Bukr

Diagnostic Equivalence of the Skin Prick Test Tape vs. Conventional Skin PrickTest

Conditions:   Allergic Rhinitis;   Allergic Asthma;   Allergic Conjunctivitis;   Food Allergy Interventions:   Diagnostic Test: Skin Prick Test;   Diagnostic Test: Skin Prick Test TAPE Sponsor:   Prof. Dr. Claus Bachert BVBA Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UFyGYr

Blood Sampling of Healthy Volunteers for Immunological Research

Condition:   Healthy Volunteers Intervention:   Other: Blood sample Sponsor:   The Netherlands Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S554XT

A Phase 1b Study of STMC-103H in Multi-Sensitized Allergic Subjects Who Are Otherwise Healthy

Condition:   Atopic Immunoglobulin E-Mediated Allergic Disorder Interventions:   Biological: STMC-103H;   Biological: Placebo Sponsors:   Siolta Therapeutics, Inc.;   Integrium Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UDV1pj

Vaccination Coverage and Level of Protection in Patients at Risk

Conditions:   Diabetes;   Chronic Kidney Disease;   Allergy;   Cystic Fibrosis;   Heart Disease Intervention:   Sponsor:   Universitaire Ziekenhuizen Leuven Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S96Lnf

Study to Evaluate the Efficacy and Safety of " Allergovac Poliplus " in Polysensitized Patients With Allergic Rhinitis/Rhinoconjunctivitis, With or Without Asthma

Conditions:   Rhinitis, Allergic;   Rhinoconjunctivitis Intervention:   Biological: Allergen Immunotherapy (AIT) Sponsor:   Roxall Medicina España S.A Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UFC8m5

Pharmacokinetic Study to Evaluate Double-Dose Levonorgestrel Emergency Contraception in Combination With Efavirenz-Based Antiretroviral Therapy or Rifampicin-Containing Anti-Tuberculosis Therapy

Conditions:   HIV Infections;   Tuberculosis Intervention:   Drug: Levonorgestrel Emergency Contraception (LNG EC) Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S7BtwT

Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies

Conditions:   Bone Marrow Transplant Complications;   Graft Versus Host Disease;   Infection Viral;   Engraft Failure;   Immunologic Suppression Interventions:   Drug: Cyclophosphamide;   Drug: ATG Sponsor:   Hospital Israelita Albert Einstein Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UGjOt8

Swedish Study of Immunotherapy for Milk Allergy in Children

Condition:   Milk Allergy Intervention:   Other: Milk protein in fresh milk Sponsor:   Umeå University Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S9Xb3q

Siderophore-profile in Allergic and Non-allergic Subjects

Conditions:   Allergy;   Healthy;   Allergic Sensitisation Intervention:   Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UDr9cY

Immunogenicity and Safety Study of Inactivated Subunit H5N1 Influenza Vaccine in Prior Recipients of Live Attenuated H2N2, H6N1 and H9N2 Influenza Vaccines and in H5N1 and Live Attenuated Vaccine Na ïve Individuals

Condition:   Influenza Intervention:   Biological: H5N1 pISV Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SdrHcQ

Iron and Pollen Allergy in Women

Conditions:   Allergy Pollen;   Healthy Interventions:   Dietary Supplement: ImmunoBon;   Dietary Supplement: Placebo Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UFyE2L

Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population

Conditions:   Hepatitis E;   Immunisation Interventions:   Biological: HEV 239;   Other: Placebo Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UCBTZ1

Allergy UK Research and Development Nurse Project

Condition:   Allergy Intervention:   Other: Nurse Led Allergy Clinic Sponsors:   University of Edinburgh;   Allergy UK Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SaN0M3

Retrospective Chart Review of Candida Fungemia

Condition:   Candida Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UxRYiu

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Conditions:   Pulmonary Invasive Mold Infections;   Pulmonary Invasive Aspergillosis Intervention:   Diagnostic Test: Non-Invasive Testing for PIMI Sponsors:   Duke University;   Children's Hospital of Philadelphia;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S9Xv2a

Food Allergen Eliminations and Combined Protocols for Obesity Reduction: a Preliminary Comparison Study

Condition:   Obesity Intervention:   Behavioral: Food Allergy Elimination + Willis Exercise Sponsor:   Galveston Clinical Research Foundation Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UCBSEr

AQUApay (AQUA Predictive Ability in Youths): Study on the Predictive Ability of the Questionnaire AQUA © in Children and Adolescents

Condition:   Young Athletes Intervention:   Diagnostic Test: Questionnaire AQUA©, pediatric version Sponsor:   Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S7Bukr

Diagnostic Equivalence of the Skin Prick Test Tape vs. Conventional Skin PrickTest

Conditions:   Allergic Rhinitis;   Allergic Asthma;   Allergic Conjunctivitis;   Food Allergy Interventions:   Diagnostic Test: Skin Prick Test;   Diagnostic Test: Skin Prick Test TAPE Sponsor:   Prof. Dr. Claus Bachert BVBA Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UFyGYr

Blood Sampling of Healthy Volunteers for Immunological Research

Condition:   Healthy Volunteers Intervention:   Other: Blood sample Sponsor:   The Netherlands Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S554XT

A Phase 1b Study of STMC-103H in Multi-Sensitized Allergic Subjects Who Are Otherwise Healthy

Condition:   Atopic Immunoglobulin E-Mediated Allergic Disorder Interventions:   Biological: STMC-103H;   Biological: Placebo Sponsors:   Siolta Therapeutics, Inc.;   Integrium Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UDV1pj

Vaccination Coverage and Level of Protection in Patients at Risk

Conditions:   Diabetes;   Chronic Kidney Disease;   Allergy;   Cystic Fibrosis;   Heart Disease Intervention:   Sponsor:   Universitaire Ziekenhuizen Leuven Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S96Lnf

Study to Evaluate the Efficacy and Safety of " Allergovac Poliplus " in Polysensitized Patients With Allergic Rhinitis/Rhinoconjunctivitis, With or Without Asthma

Conditions:   Rhinitis, Allergic;   Rhinoconjunctivitis Intervention:   Biological: Allergen Immunotherapy (AIT) Sponsor:   Roxall Medicina España S.A Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UFC8m5

Pharmacokinetic Study to Evaluate Double-Dose Levonorgestrel Emergency Contraception in Combination With Efavirenz-Based Antiretroviral Therapy or Rifampicin-Containing Anti-Tuberculosis Therapy

Conditions:   HIV Infections;   Tuberculosis Intervention:   Drug: Levonorgestrel Emergency Contraception (LNG EC) Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S7BtwT

Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies

Conditions:   Bone Marrow Transplant Complications;   Graft Versus Host Disease;   Infection Viral;   Engraft Failure;   Immunologic Suppression Interventions:   Drug: Cyclophosphamide;   Drug: ATG Sponsor:   Hospital Israelita Albert Einstein Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UGjOt8

Swedish Study of Immunotherapy for Milk Allergy in Children

Condition:   Milk Allergy Intervention:   Other: Milk protein in fresh milk Sponsor:   Umeå University Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S9Xb3q

Siderophore-profile in Allergic and Non-allergic Subjects

Conditions:   Allergy;   Healthy;   Allergic Sensitisation Intervention:   Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UDr9cY

Immunogenicity and Safety Study of Inactivated Subunit H5N1 Influenza Vaccine in Prior Recipients of Live Attenuated H2N2, H6N1 and H9N2 Influenza Vaccines and in H5N1 and Live Attenuated Vaccine Na ïve Individuals

Condition:   Influenza Intervention:   Biological: H5N1 pISV Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SdrHcQ

Iron and Pollen Allergy in Women

Conditions:   Allergy Pollen;   Healthy Interventions:   Dietary Supplement: ImmunoBon;   Dietary Supplement: Placebo Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UFyE2L

Evaluation of salivary metabolomics in oral leukoplakia and oral squamous cell carcinoma

Abstract

Background

Metabolomics is the study of metabolome which describes the full repertoire of small molecules and the analysis of salivary metabolomics may help in identifying tumor specific biomarkers for early diagnosis and prediction of tumor progression. The aim of the study was to evaluate the clinical utility of salivary metabolites in oral leukoplakia and oral squamous cell carcinoma.

Methods

Salivary metabolomic profile of patients diagnosed with oral leukoplakia (n=21) and oral squamous cell carcinoma (n=22) were compared with apparently normal controls (n=18) using QTOF‐ liquid chromatography mass spectrometry. MassHunter profile software and Metlin database was used for metabolite identification. ANOVA analysis to identify the regulation of metabolites between the three groups; t‐test (p<0.05) to signify the changes between two groups and chi‐square test (p<0.05) to indicate the presence or absence of metabolites in the study participants of the three groups was performed.

Results

Significant upregulation of 1‐methylhistidine, inositol 1,3,4‐ triphosphate, d‐glycerate‐2‐phosphate, 4‐nitoquinolone‐1‐oxide, 2‐oxoarginine, norcocaine nitroxide, sphinganine‐1‐phosphate and pseudouridine in oral leukoplakia and OSCC was noted. Downregulated compounds in the diseased groups included L‐homocysteic acid, ubiquinone, neuraminic acid and estradiol valerate.

Conclusion

A range of salivary metabolites were significantly altered in oral leukoplakia and oral squamous cell carcinoma. Further, it is necessary to evaluate the clinical utility of the individual metabolites in preventing malignant transformation of oral leukoplakia and to improve prognosis of oral squamous cell carcinoma.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G9iU52

Evaluation of salivary metabolomics in oral leukoplakia and oral squamous cell carcinoma

Abstract

Background

Metabolomics is the study of metabolome which describes the full repertoire of small molecules and the analysis of salivary metabolomics may help in identifying tumor specific biomarkers for early diagnosis and prediction of tumor progression. The aim of the study was to evaluate the clinical utility of salivary metabolites in oral leukoplakia and oral squamous cell carcinoma.

Methods

Salivary metabolomic profile of patients diagnosed with oral leukoplakia (n=21) and oral squamous cell carcinoma (n=22) were compared with apparently normal controls (n=18) using QTOF‐ liquid chromatography mass spectrometry. MassHunter profile software and Metlin database was used for metabolite identification. ANOVA analysis to identify the regulation of metabolites between the three groups; t‐test (p<0.05) to signify the changes between two groups and chi‐square test (p<0.05) to indicate the presence or absence of metabolites in the study participants of the three groups was performed.

Results

Significant upregulation of 1‐methylhistidine, inositol 1,3,4‐ triphosphate, d‐glycerate‐2‐phosphate, 4‐nitoquinolone‐1‐oxide, 2‐oxoarginine, norcocaine nitroxide, sphinganine‐1‐phosphate and pseudouridine in oral leukoplakia and OSCC was noted. Downregulated compounds in the diseased groups included L‐homocysteic acid, ubiquinone, neuraminic acid and estradiol valerate.

Conclusion

A range of salivary metabolites were significantly altered in oral leukoplakia and oral squamous cell carcinoma. Further, it is necessary to evaluate the clinical utility of the individual metabolites in preventing malignant transformation of oral leukoplakia and to improve prognosis of oral squamous cell carcinoma.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G9iU52

Are penicillin allergies fake news?

Penicillin allergies are fake news. More than 95 percent of people with penicillin allergies are not allergic.   A recent article highlighted the opportunity anethesiologists have in helping evaluate beta-lactam allergies, in particular to cephalosporins. The author was correct, these allergies are common and usually not real. Unfortunately, premedication with antihistamines as suggested may mask allergic reactions and […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HPG1Dx

Food avoidance strategies in eosinophilic oesophagitis

Abstract

EoE is a chronic disease associated with significant morbidity that can result in permanent fibrosis and stricture formation. Given the complexity a multidisciplinary approach is recommended to manage these patients. In the majority of children with EoE not responsive to proton pump inhibitors (PPI), inflammation is driven by sensitivity to foods and treatment with an elimination diet can be effective.

Foods most commonly identified to trigger EoE in children are milk and wheat, but egg, soy, meats and grains can also be triggers. Foods can be eliminated using a step‐down or step‐up approach. If the goal is to achieve quick remission elemental diet or six food elimination diets are the most effective. A step‐up approach starting from a 1‐2 food elimination diet and increasing the number of foods based on a personalised dietary approach is recommended if the goal is to achieve remission using the least number of endoscopies and with increased acceptability to the patient.

Children with EoE on elimination diets require frequent monitoring of growth and nutrition, as well as screening for symptoms of EoE, allergy, and mindfulness regarding psychosocial impact of chronic disease on the family and child. Current research focused on tools to select patients who mostly will benefit from dietary treatment, identify relevant food allergens, obtain oesophageal tissue non‐invasively and induce tolerance will greatly improve the treatment of EoE.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DQqU8O

Are penicillin allergies fake news?

Penicillin allergies are fake news. More than 95 percent of people with penicillin allergies are not allergic.   A recent article highlighted the opportunity anethesiologists have in helping evaluate beta-lactam allergies, in particular to cephalosporins. The author was correct, these allergies are common and usually not real. Unfortunately, premedication with antihistamines as suggested may mask allergic reactions and […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HPG1Dx

Food avoidance strategies in eosinophilic oesophagitis

Abstract

EoE is a chronic disease associated with significant morbidity that can result in permanent fibrosis and stricture formation. Given the complexity a multidisciplinary approach is recommended to manage these patients. In the majority of children with EoE not responsive to proton pump inhibitors (PPI), inflammation is driven by sensitivity to foods and treatment with an elimination diet can be effective.

Foods most commonly identified to trigger EoE in children are milk and wheat, but egg, soy, meats and grains can also be triggers. Foods can be eliminated using a step‐down or step‐up approach. If the goal is to achieve quick remission elemental diet or six food elimination diets are the most effective. A step‐up approach starting from a 1‐2 food elimination diet and increasing the number of foods based on a personalised dietary approach is recommended if the goal is to achieve remission using the least number of endoscopies and with increased acceptability to the patient.

Children with EoE on elimination diets require frequent monitoring of growth and nutrition, as well as screening for symptoms of EoE, allergy, and mindfulness regarding psychosocial impact of chronic disease on the family and child. Current research focused on tools to select patients who mostly will benefit from dietary treatment, identify relevant food allergens, obtain oesophageal tissue non‐invasively and induce tolerance will greatly improve the treatment of EoE.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DQqU8O

Patient Reported Outcome Measures (PROMs) and maintenance events in 2‐implant supported mandibular overdenture patients: A five‐year prospective study

Abstract

Objective

To prospectively evaluate Patient Reported Outcome Measures (PROMs) and treatment outcomes of mandibular two‐implant retained overdentures (IOD) in an edentulous geriatric cohort with history of deficient Complete Dentures (CD).

Materials and Methods

103 patients with deficient CD received new optimal CD. After a period of 3 months, 80 of the patients voluntarily received IOD. Outcomes collected at pre‐, post‐CD/post‐IOD treatment annually up to 5 years, included: A) Clinical outcomes: denture‐quality (Woelfel's index), complications, and maintenance events, B) PROMs: patient complaints (maxillary, mandibular functional complaint scores, generic aesthetic complaint scores, frequency, and intensity of complaints) and patient satisfaction, C) Maintenance events: technical complications and adverse events.

Results

5 years data were collected from 67 patients (mean age at initiation =71.3 years, mean observation=5.9 years) with cumulative implant survival‐rate=98.72%. Multiple comparisons for 8 time‐points showed significant improvements in denture‐quality and PROMs after new CD and IOD delivery. Further significant improvements were only after IOD delivery in: mandibular denture‐quality, mandibular and generic functional complaints, frequency, intensity of complaints, and overall patient satisfaction score. Thereafter, denture‐quality and PROMs remained stable. Maintenance events clustered on 1st year and within a minority of patients. Technical complications and overall maintenance events significantly correlated with overall patient satisfaction score at 1st year.

Conclusions

Mandibular IOD was a beneficial treatment option for seniors with history of deficient CD, improving denture‐quality, patient satisfaction, and reducing patient complaints up to 5 years. Maintenance events clustered on 1st year, showing no significant impact on long‐term patient satisfaction and other PROMs.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rz9SQ1

Patient Reported Outcome Measures (PROMs) and maintenance events in 2‐implant supported mandibular overdenture patients: A five‐year prospective study

Abstract

Objective

To prospectively evaluate Patient Reported Outcome Measures (PROMs) and treatment outcomes of mandibular two‐implant retained overdentures (IOD) in an edentulous geriatric cohort with history of deficient Complete Dentures (CD).

Materials and Methods

103 patients with deficient CD received new optimal CD. After a period of 3 months, 80 of the patients voluntarily received IOD. Outcomes collected at pre‐, post‐CD/post‐IOD treatment annually up to 5 years, included: A) Clinical outcomes: denture‐quality (Woelfel's index), complications, and maintenance events, B) PROMs: patient complaints (maxillary, mandibular functional complaint scores, generic aesthetic complaint scores, frequency, and intensity of complaints) and patient satisfaction, C) Maintenance events: technical complications and adverse events.

Results

5 years data were collected from 67 patients (mean age at initiation =71.3 years, mean observation=5.9 years) with cumulative implant survival‐rate=98.72%. Multiple comparisons for 8 time‐points showed significant improvements in denture‐quality and PROMs after new CD and IOD delivery. Further significant improvements were only after IOD delivery in: mandibular denture‐quality, mandibular and generic functional complaints, frequency, intensity of complaints, and overall patient satisfaction score. Thereafter, denture‐quality and PROMs remained stable. Maintenance events clustered on 1st year and within a minority of patients. Technical complications and overall maintenance events significantly correlated with overall patient satisfaction score at 1st year.

Conclusions

Mandibular IOD was a beneficial treatment option for seniors with history of deficient CD, improving denture‐quality, patient satisfaction, and reducing patient complaints up to 5 years. Maintenance events clustered on 1st year, showing no significant impact on long‐term patient satisfaction and other PROMs.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rz9SQ1

Occupational lichenoid allergic contact dermatitis caused by tin

Allergic reactions to tin were previously reported in the literature (1,2). True cases of allergic contact dermatitis, however, are very rare.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RBYkeI

Occupational lichenoid allergic contact dermatitis caused by tin

Allergic reactions to tin were previously reported in the literature (1,2). True cases of allergic contact dermatitis, however, are very rare.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RBYkeI

Natural remedies for allergies

(Natural News) Seasonal allergies are often the bane of anyone who happens to have a hypersensitive immune system. Allergens are typically innocent substances, but when your body detects their presence, your immune system treats them as harmful intruders and responds accordingly. This is what causes an allergic reaction. While it is ideal to avoid exposure to allergens... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D3QLZk

Natural remedies for allergies

(Natural News) Seasonal allergies are often the bane of anyone who happens to have a hypersensitive immune system. Allergens are typically innocent substances, but when your body detects their presence, your immune system treats them as harmful intruders and responds accordingly. This is what causes an allergic reaction. While it is ideal to avoid exposure to allergens... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D3QLZk

Natural remedies for allergies

(Natural News) Seasonal allergies are often the bane of anyone who happens to have a hypersensitive immune system. Allergens are typically innocent substances, but when your body detects their presence, your immune system treats them as harmful intruders and responds accordingly. This is what causes an allergic reaction. While it is ideal to avoid exposure to allergens... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D3QLZk

Natural remedies for allergies

(Natural News) Seasonal allergies are often the bane of anyone who happens to have a hypersensitive immune system. Allergens are typically innocent substances, but when your body detects their presence, your immune system treats them as harmful intruders and responds accordingly. This is what causes an allergic reaction. While it is ideal to avoid exposure to allergens... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D3QLZk

Stepwise approach towards adoption of allergen immunotherapy for allergic rhinitis and asthma patients in daily practice in Belgium: a BelSACI-Abeforcal-EUFOREA statement

Abstract

Allergic rhinitis (AR) affects 23–30% of the European population with equal prevalence reported in Belgium. Despite guidelines on the correct use of effective treatment, up to 40% of AR patients remain uncontrolled. Allergen immunotherapy (AIT) has been shown to improve the level of control up to 84% of patients being controlled by AIT. Recently, new guidelines for AIT have been published, supporting the clinical evidence for effectiveness of various subcutaneous and sublingual products for AIT in patients who are allergic to airborne allergens. AIT in AR patients not only reduces nasal and/or ocular symptoms but also induces tolerance and has preventive potential. Adoption of AIT into daily clinical practice in Belgium and other European countries is hampered primarily by reimbursement issues of each of the single products but also by several patient- and physician-related factors. Patients need to be better informed about the effectiveness of AIT and the different routes of administration of AIT. Physicians dealing with AR patients should inform patients on tolerance-inducing effects of AIT and are in the need of a harmonized and practical guide that supports them in selecting eligible patients for AIT, in choosing evidence-based AIT products and in following treatment protocols with proven efficacy. Therefore, a stepwise and holistic approach is needed for better adoption of AIT in the real-life setting in Belgium.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D7sUId

Stepwise approach towards adoption of allergen immunotherapy for allergic rhinitis and asthma patients in daily practice in Belgium: a BelSACI-Abeforcal-EUFOREA statement

Abstract

Allergic rhinitis (AR) affects 23–30% of the European population with equal prevalence reported in Belgium. Despite guidelines on the correct use of effective treatment, up to 40% of AR patients remain uncontrolled. Allergen immunotherapy (AIT) has been shown to improve the level of control up to 84% of patients being controlled by AIT. Recently, new guidelines for AIT have been published, supporting the clinical evidence for effectiveness of various subcutaneous and sublingual products for AIT in patients who are allergic to airborne allergens. AIT in AR patients not only reduces nasal and/or ocular symptoms but also induces tolerance and has preventive potential. Adoption of AIT into daily clinical practice in Belgium and other European countries is hampered primarily by reimbursement issues of each of the single products but also by several patient- and physician-related factors. Patients need to be better informed about the effectiveness of AIT and the different routes of administration of AIT. Physicians dealing with AR patients should inform patients on tolerance-inducing effects of AIT and are in the need of a harmonized and practical guide that supports them in selecting eligible patients for AIT, in choosing evidence-based AIT products and in following treatment protocols with proven efficacy. Therefore, a stepwise and holistic approach is needed for better adoption of AIT in the real-life setting in Belgium.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D7sUId

F < sub > 0 < /sub > Timing and Tone Contrasts in Luganda

This article explores this contrast through an instrumental study of the timing of f0 events in Luganda. It was found that the 2-tone classes differed in the timing of both the f0 rise and the subsequent f0 fall, supporting a reanalysis of the contrast as one between an early high tone and a late high tone. It was also found that for the speakers in this study, the contrast was limited to syllables with long vowels. The timing of f0 events was sensitive to the duration of segments in the CVC interval centered on the high-toned syllable, including non-moraic elements and consonants outside the syllable. The association of a tone to a syllable identifies the segments relevant for the timing of the f0 contour, but that timing is not directly sensitive to the interval of the syllable.Phonetica...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G9tOI7

The relative contribution of computer assisted prosody training vs. instructor based prosody teaching in developing speaking skills by interpreter trainees: an experimental study

Publication date: Available online 2 February 2019Source: Speech CommunicationAuthor(s): Mahmood Yenkimaleki, Vincent J. van Heuven, Hossein MoradimokhlesAbstractThe present study investigates the relative contribution of computer assisted prosody training (CAPT) vs. instructor based prosody teaching (IBPT) on developing speaking skills by interpreter trainees. Three groups of student interpreters were formed. All were native speakers of Farsi who studied English translation and interpreting at the BA level at the University of Applied Sciences in Tehran, Iran. Participants were assigned to groups at random. No significant differences in speaking skills could be established between the groups prior to the experiment. The control group listened to authentic audio tracks in English and discu...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D8Zn0D

Editorial Board

Publication date: February 2019Source: Lingua, Volume 219Author(s): (Source: Lingua)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G86cn0

Examining the associations between children's receptive language skills and developmental domains in the United States and Turkey.

This study examined the relations between receptive language development and other developmental domains of preschoolers from low-income families, through an inter-cultural perspective involving the United States and Turkey. A total of 471 children and their caregivers participated in Turkey, while 287 participated in the United States. Children's development was assessed using the Ages and Stages Questionnaire for both samples. Different versions of the Peabody Picture Vocabulary Test were used for Turkish and US samples, to measure receptive language development. Results revealed similar patterns, with some differences, between the two countries. Receptive language predicted only communication and personal-social scales in the Turkish sample, while the US children's receptive language sk...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D3k7a5

Data-driven item selection for the Shirts and Shoes Test.

CONCLUSIONS: Item Response Theory can be used productively to identify items that fail to add to the reliability and validity of a test during the earliest stages of test development. The number of items culled for this test demonstrates that the content of the items alone does not assure that the items perform in ways that promote accurate skill measurement. PMID: 30703736 [PubMed - as supplied by publisher] (Source: Journal of Communication Disorders)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G9grrw

F < sub > 0 < /sub > Timing and Tone Contrasts in Luganda

This article explores this contrast through an instrumental study of the timing of f0 events in Luganda. It was found that the 2-tone classes differed in the timing of both the f0 rise and the subsequent f0 fall, supporting a reanalysis of the contrast as one between an early high tone and a late high tone. It was also found that for the speakers in this study, the contrast was limited to syllables with long vowels. The timing of f0 events was sensitive to the duration of segments in the CVC interval centered on the high-toned syllable, including non-moraic elements and consonants outside the syllable. The association of a tone to a syllable identifies the segments relevant for the timing of the f0 contour, but that timing is not directly sensitive to the interval of the syllable.Phonetica...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G9tOI7

The relative contribution of computer assisted prosody training vs. instructor based prosody teaching in developing speaking skills by interpreter trainees: an experimental study

Publication date: Available online 2 February 2019Source: Speech CommunicationAuthor(s): Mahmood Yenkimaleki, Vincent J. van Heuven, Hossein MoradimokhlesAbstractThe present study investigates the relative contribution of computer assisted prosody training (CAPT) vs. instructor based prosody teaching (IBPT) on developing speaking skills by interpreter trainees. Three groups of student interpreters were formed. All were native speakers of Farsi who studied English translation and interpreting at the BA level at the University of Applied Sciences in Tehran, Iran. Participants were assigned to groups at random. No significant differences in speaking skills could be established between the groups prior to the experiment. The control group listened to authentic audio tracks in English and discu...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D8Zn0D

Editorial Board

Publication date: February 2019Source: Lingua, Volume 219Author(s): (Source: Lingua)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G86cn0

Examining the associations between children's receptive language skills and developmental domains in the United States and Turkey.

This study examined the relations between receptive language development and other developmental domains of preschoolers from low-income families, through an inter-cultural perspective involving the United States and Turkey. A total of 471 children and their caregivers participated in Turkey, while 287 participated in the United States. Children's development was assessed using the Ages and Stages Questionnaire for both samples. Different versions of the Peabody Picture Vocabulary Test were used for Turkish and US samples, to measure receptive language development. Results revealed similar patterns, with some differences, between the two countries. Receptive language predicted only communication and personal-social scales in the Turkish sample, while the US children's receptive language sk...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D3k7a5

Data-driven item selection for the Shirts and Shoes Test.

CONCLUSIONS: Item Response Theory can be used productively to identify items that fail to add to the reliability and validity of a test during the earliest stages of test development. The number of items culled for this test demonstrates that the content of the items alone does not assure that the items perform in ways that promote accurate skill measurement. PMID: 30703736 [PubMed - as supplied by publisher] (Source: Journal of Communication Disorders)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G9grrw

ATA supports dialogue on emergency preparedness around nuclear power stations

Here's what could happen in a nuclear disaster in Washtenaw County

The American Thyroid Association has called for pre-distribution of potassium iodide, also known as KI, to households within a 10-mile radius of nuclear power plants such as Fermi 2, and stockpiling it in public facilities such as schools, hospitals, clinics, post offices and police and fire stations in up to a 50-mile radius.
Michigan Live (www.MLive.com)

Read More…

The post ATA supports dialogue on emergency preparedness around nuclear power stations appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BiUiTr

ATA supports dialogue on emergency preparedness around nuclear power stations

Here's what could happen in a nuclear disaster in Washtenaw County

The American Thyroid Association has called for pre-distribution of potassium iodide, also known as KI, to households within a 10-mile radius of nuclear power plants such as Fermi 2, and stockpiling it in public facilities such as schools, hospitals, clinics, post offices and police and fire stations in up to a 50-mile radius.
Michigan Live (www.MLive.com)

Read More…

The post ATA supports dialogue on emergency preparedness around nuclear power stations appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BiUiTr

Controlled comparative clinical trial of hearing benefit outcomes for users of the Cochlear ™ Nucleus® 7 Sound Processor with mobile connectivity

. (Source: Cochlear Implants International)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GlEse8

Controlled comparative clinical trial of hearing benefit outcomes for users of the Cochlear ™ Nucleus® 7 Sound Processor with mobile connectivity

. (Source: Cochlear Implants International)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GlEse8

ATA supports dialogue on emergency preparedness around nuclear power stations

Here's what could happen in a nuclear disaster in Washtenaw County

The American Thyroid Association has called for pre-distribution of potassium iodide, also known as KI, to households within a 10-mile radius of nuclear power plants such as Fermi 2, and stockpiling it in public facilities such as schools, hospitals, clinics, post offices and police and fire stations in up to a 50-mile radius.
Michigan Live (www.MLive.com)

Read More…

The post ATA supports dialogue on emergency preparedness around nuclear power stations appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BiUiTr

ATA supports dialogue on emergency preparedness around nuclear power stations

Here's what could happen in a nuclear disaster in Washtenaw County

The American Thyroid Association has called for pre-distribution of potassium iodide, also known as KI, to households within a 10-mile radius of nuclear power plants such as Fermi 2, and stockpiling it in public facilities such as schools, hospitals, clinics, post offices and police and fire stations in up to a 50-mile radius.
Michigan Live (www.MLive.com)

Read More…

The post ATA supports dialogue on emergency preparedness around nuclear power stations appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BiUiTr

Searching for an end to peanut allergies

While you may have grown up without ever hearing of a food allergy, today an estimated 26 million people (including at least six million children) have one. But researchers now think they have the answer to possibly eliminating peanut allergies. How? By feeding kids peanuts early and often. Tony Dokoupil reports on a rare reversal of medical advice. (Source: Health News: CBSNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S4xUHG

Searching for an end to peanut allergies

While you may have grown up without ever hearing of a food allergy, today an estimated 26 million people (including at least six million children) have one. But researchers now think they have the answer to possibly eliminating peanut allergies. How? By feeding kids peanuts early and often. Tony Dokoupil reports on a rare reversal of medical advice. (Source: Health News: CBSNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S4xUHG

Searching for an end to peanut allergies

While you may have grown up without ever hearing of a food allergy, today an estimated 26 million people (including at least six million children) have one. But researchers now think they have the answer to possibly eliminating peanut allergies. How? By feeding kids peanuts early and often. Tony Dokoupil reports on a rare reversal of medical advice. (Source: Health News: CBSNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S4xUHG

Searching for an end to peanut allergies

While you may have grown up without ever hearing of a food allergy, today an estimated 26 million people (including at least six million children) have one. But researchers now think they have the answer to possibly eliminating peanut allergies. How? By feeding kids peanuts early and often. Tony Dokoupil reports on a rare reversal of medical advice. (Source: Health News: CBSNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S4xUHG

An end to food allergies?

26 million people, including 6 million kids, are allergic to one food or another, with peanuts producing one of the most severe reactions; might a reversal of medical advice slow or even eliminate the problem? (Source: Health News: CBSNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t5zz0V

An end to food allergies?

26 million people, including 6 million kids, are allergic to one food or another, with peanuts producing one of the most severe reactions; might a reversal of medical advice slow or even eliminate the problem? (Source: Health News: CBSNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t5zz0V

An end to food allergies?

26 million people, including 6 million kids, are allergic to one food or another, with peanuts producing one of the most severe reactions; might a reversal of medical advice slow or even eliminate the problem? (Source: Health News: CBSNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t5zz0V

Mayo Clinic Q and A: A pet allergy doesn't mean you have to live without furry family members

DEAR MAYO CLINIC:?My 8-year-old recently was diagnosed with a pet allergy. But we have a cat that our daughter picked out when it was a kitten, and she's very attached to it. She's heartbroken that her allergy may mean she has to say goodbye to her furry friend. Can we keep the cat without endangering [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BgsFu0

An end to food allergies?

26 million people, including 6 million kids, are allergic to one food or another, with peanuts producing one of the most severe reactions; might a reversal of medical advice slow or even eliminate the problem? (Source: Health News: CBSNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t5zz0V

Mayo Clinic Q and A: A pet allergy doesn't mean you have to live without furry family members

DEAR MAYO CLINIC:?My 8-year-old recently was diagnosed with a pet allergy. But we have a cat that our daughter picked out when it was a kitten, and she's very attached to it. She's heartbroken that her allergy may mean she has to say goodbye to her furry friend. Can we keep the cat without endangering [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BgsFu0

Mayo Clinic Q and A: A pet allergy doesn't mean you have to live without furry family members

DEAR MAYO CLINIC:?My 8-year-old recently was diagnosed with a pet allergy. But we have a cat that our daughter picked out when it was a kitten, and she's very attached to it. She's heartbroken that her allergy may mean she has to say goodbye to her furry friend. Can we keep the cat without endangering [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BgsFu0

Mayo Clinic Q and A: A pet allergy doesn't mean you have to live without furry family members

DEAR MAYO CLINIC:?My 8-year-old recently was diagnosed with a pet allergy. But we have a cat that our daughter picked out when it was a kitten, and she's very attached to it. She's heartbroken that her allergy may mean she has to say goodbye to her furry friend. Can we keep the cat without endangering [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BgsFu0

Asthma Status and Risks among Lesbian, Gay, and Bisexual Adults in the United States: A Scoping Review

Publication date: Available online 2 February 2019

Source: Annals of Allergy, Asthma & Immunology

Author(s): Cindy B. Veldhuis, Jean-Marie Bruzzese, Tonda L. Hughes, Maureen George

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MLEvAT

Asthma Status and Risks among Lesbian, Gay, and Bisexual Adults in the United States: A Scoping Review

Publication date: Available online 2 February 2019

Source: Annals of Allergy, Asthma & Immunology

Author(s): Cindy B. Veldhuis, Jean-Marie Bruzzese, Tonda L. Hughes, Maureen George

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MLEvAT

Sliding window correlation analysis: Modulating window shape for dynamic brain connectivity in resting state

Publication date: Available online 2 February 2019

Source: NeuroImage

Author(s): Fatemeh Mokhtari, Milad I. Akhlaghi, Sean L. Simpson, Guorong Wu, Paul J. Laurienti

Abstract

The sliding window correlation (SWC) analysis is a straightforward and common approach for evaluating dynamic functional connectivity. Despite the fact that sliding window analyses have been long used, there are still considerable technical issues associated with the approach. A great effort has recently been dedicated to investigate the window setting effects on dynamic connectivity estimation. In this direction, tapered windows have been proposed to alleviate the effect of sudden changes associated with the edges of rectangular windows. Nevertheless, the majority of the windows exploited to estimate brain connectivity tend to suppress dynamic correlations, especially those with faster variations over time. Here, we introduced a window named modulated rectangular (mRect) to address the suppressing effect associated with the conventional windows. We provided a frequency domain analysis using simulated time series to investigate how sliding window analysis (using the regular window functions, e.g. rectangular and tapered windows) may lead to unwanted spectral modulations, and then we showed how this issue can be alleviated through the mRect window. Moreover, we created simulated dynamic network data with altering states over time using simulated fMRI time series, to examine the performance of different windows in tracking network states. We quantified the state identification rate of different window functions through the Jaccard index, and observed superior performance of the mRect window compared to the conventional window functions. Overall, the proposed window function provides an approach that improves SWC estimations, and thus the subsequent inferences and interpretations based on the connectivity network analyses.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tvut9C

Sliding window correlation analysis: Modulating window shape for dynamic brain connectivity in resting state

Publication date: Available online 2 February 2019

Source: NeuroImage

Author(s): Fatemeh Mokhtari, Milad I. Akhlaghi, Sean L. Simpson, Guorong Wu, Paul J. Laurienti

Abstract

The sliding window correlation (SWC) analysis is a straightforward and common approach for evaluating dynamic functional connectivity. Despite the fact that sliding window analyses have been long used, there are still considerable technical issues associated with the approach. A great effort has recently been dedicated to investigate the window setting effects on dynamic connectivity estimation. In this direction, tapered windows have been proposed to alleviate the effect of sudden changes associated with the edges of rectangular windows. Nevertheless, the majority of the windows exploited to estimate brain connectivity tend to suppress dynamic correlations, especially those with faster variations over time. Here, we introduced a window named modulated rectangular (mRect) to address the suppressing effect associated with the conventional windows. We provided a frequency domain analysis using simulated time series to investigate how sliding window analysis (using the regular window functions, e.g. rectangular and tapered windows) may lead to unwanted spectral modulations, and then we showed how this issue can be alleviated through the mRect window. Moreover, we created simulated dynamic network data with altering states over time using simulated fMRI time series, to examine the performance of different windows in tracking network states. We quantified the state identification rate of different window functions through the Jaccard index, and observed superior performance of the mRect window compared to the conventional window functions. Overall, the proposed window function provides an approach that improves SWC estimations, and thus the subsequent inferences and interpretations based on the connectivity network analyses.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tvut9C

Importance of root uptake of 14CO2 on 14C transfer to plants impacted by below-ground 14CH4 release

Publication date: May 2019

Source: Journal of Environmental Radioactivity, Volume 201

Author(s): Masakazu Ota, Taku Tanaka

Abstract

¹⁴C-labelled methane (¹⁴CH₄) released from deep underground radioactive waste disposal facilities can be a below-ground source of ¹⁴CO₂ owing to microbial oxidation of ¹⁴CH₄ to ¹⁴CO₂ in soils. Environmental ¹⁴C models assume that the transfer of ¹⁴CO₂ from soil to plant occurs via foliar uptake of ¹⁴CO₂. Nevertheless, the importance of ¹⁴CO₂ root uptake is not well understood. In the present study, below-ground transport and oxidation of ¹⁴CH₄ were modeled and incorporated into an existing land-surface ¹⁴CO₂ model (SOLVEG-II) to assess the relative importance of root uptake and foliar uptake on ¹⁴CO₂ transfer from soil to plants. Performance of the model in calculating the below-ground dynamics of ¹⁴CH₄ was validated by simulating a field experiment of ¹³CH₄ (as a substitute for ¹⁴CH₄) injection into subsoil in a wheat field in the UK. The proposed model simulation was then applied to ¹⁴C transfer in a hypothetical ecosystem impacted by continuous ¹⁴CH₄ input from the water table (bottom of 1-m thick soil), which simulated continuous release of ¹⁴CH₄ from a deep underground radioactive waste disposal facility. The contrast between the results obtained from the model calculation that assumed different distributions of roots (rooting depths of 11 cm, or 97 cm) and methane oxidation (characterized by e-folding depths of 5 cm, 20 cm, or 80 cm) in the soil provided insight into the relative importance of root uptake and foliar uptake pathways. In the shallowly rooted ecosystem with rooting depth of 11 cm, foliar uptake of ¹⁴CO₂ was significant, accounting for 80% of the ¹⁴C accumulation (as organic ¹⁴C) in the plant (leaf compartment). By contrast, in a deeply rooted ecosystem (rooting depth of 97 cm), where the root penetrated to depths close to the water-table, more than half (63%) the ¹⁴C accumulated in the plant was transferred via the root uptake pathway. We found that ¹⁴CO₂ root uptake (thus ¹⁴C accumulation in the plant) in this ecosystem depended on the distribution of methane oxidation in the soil; all ¹⁴C accumulated in the plant was transferred by the root uptake pathway when methane oxidation occurred at considerable depths (e-folding depths of 20 cm, or 80 cm) in the soil. The high level of ¹⁴CO₂ root uptake was ascribed to the oxidation of added ¹⁴CH₄ (i.e., production of ¹⁴CO₂) in the deep part of the soil and the subsequent high level of root uptake of the deep soil-water containing ¹⁴CO₂. These results indicate that ¹⁴CO₂ root uptake contributes significantly to ¹⁴CO₂ transfer to plants if ¹⁴CH₄ oxidation occurs at great depths and roots penetrate deeply into the soil. It is recommended that current environmental ¹⁴C models must be refined to consider the importance of the root uptake pathway to ensure that dose estimates of ¹⁴CH₄ release from deep underground waste disposal facilities are accurate.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SpMvNs

Importance of root uptake of 14CO2 on 14C transfer to plants impacted by below-ground 14CH4 release

Publication date: May 2019

Source: Journal of Environmental Radioactivity, Volume 201

Author(s): Masakazu Ota, Taku Tanaka

Abstract

¹⁴C-labelled methane (¹⁴CH₄) released from deep underground radioactive waste disposal facilities can be a below-ground source of ¹⁴CO₂ owing to microbial oxidation of ¹⁴CH₄ to ¹⁴CO₂ in soils. Environmental ¹⁴C models assume that the transfer of ¹⁴CO₂ from soil to plant occurs via foliar uptake of ¹⁴CO₂. Nevertheless, the importance of ¹⁴CO₂ root uptake is not well understood. In the present study, below-ground transport and oxidation of ¹⁴CH₄ were modeled and incorporated into an existing land-surface ¹⁴CO₂ model (SOLVEG-II) to assess the relative importance of root uptake and foliar uptake on ¹⁴CO₂ transfer from soil to plants. Performance of the model in calculating the below-ground dynamics of ¹⁴CH₄ was validated by simulating a field experiment of ¹³CH₄ (as a substitute for ¹⁴CH₄) injection into subsoil in a wheat field in the UK. The proposed model simulation was then applied to ¹⁴C transfer in a hypothetical ecosystem impacted by continuous ¹⁴CH₄ input from the water table (bottom of 1-m thick soil), which simulated continuous release of ¹⁴CH₄ from a deep underground radioactive waste disposal facility. The contrast between the results obtained from the model calculation that assumed different distributions of roots (rooting depths of 11 cm, or 97 cm) and methane oxidation (characterized by e-folding depths of 5 cm, 20 cm, or 80 cm) in the soil provided insight into the relative importance of root uptake and foliar uptake pathways. In the shallowly rooted ecosystem with rooting depth of 11 cm, foliar uptake of ¹⁴CO₂ was significant, accounting for 80% of the ¹⁴C accumulation (as organic ¹⁴C) in the plant (leaf compartment). By contrast, in a deeply rooted ecosystem (rooting depth of 97 cm), where the root penetrated to depths close to the water-table, more than half (63%) the ¹⁴C accumulated in the plant was transferred via the root uptake pathway. We found that ¹⁴CO₂ root uptake (thus ¹⁴C accumulation in the plant) in this ecosystem depended on the distribution of methane oxidation in the soil; all ¹⁴C accumulated in the plant was transferred by the root uptake pathway when methane oxidation occurred at considerable depths (e-folding depths of 20 cm, or 80 cm) in the soil. The high level of ¹⁴CO₂ root uptake was ascribed to the oxidation of added ¹⁴CH₄ (i.e., production of ¹⁴CO₂) in the deep part of the soil and the subsequent high level of root uptake of the deep soil-water containing ¹⁴CO₂. These results indicate that ¹⁴CO₂ root uptake contributes significantly to ¹⁴CO₂ transfer to plants if ¹⁴CH₄ oxidation occurs at great depths and roots penetrate deeply into the soil. It is recommended that current environmental ¹⁴C models must be refined to consider the importance of the root uptake pathway to ensure that dose estimates of ¹⁴CH₄ release from deep underground waste disposal facilities are accurate.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SpMvNs

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Conditions:   Pulmonary Invasive Mold Infections;   Pulmonary Invasive Aspergillosis Intervention:   Diagnostic Test: Non-Invasive Testing for PIMI Sponsors:   Duke University;   Children's Hospital of Philadelphia;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S5Gaal

Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet

Conditions:   Intervention;   Food Allergy;   Food Preferences;   Food Intolerance;   Diet Habit;   Diet Modification Intervention:   Behavioral: Multicomponent intervention Sponsors:   University Rovira i Virgili;   Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D41YsT

Allergy UK Research and Development Nurse Project

Condition:   Allergy Intervention:   Other: Nurse Led Allergy Clinic Sponsors:   University of Edinburgh;   Allergy UK Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D6EUtf

Allergy UK Research and Development Nurse Project

Condition:   Allergy Intervention:   Other: Nurse Led Allergy Clinic Sponsors:   University of Edinburgh;   Allergy UK Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D6EUtf

Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population

Conditions:   Hepatitis E;   Immunisation Interventions:   Biological: HEV 239;   Other: Placebo Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S8gRVm

Retrospective Chart Review of Candida Fungemia

Condition:   Candida Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S62j8D

Food Allergen Eliminations and Combined Protocols for Obesity Reduction: a Preliminary Comparison Study

Condition:   Obesity Intervention:   Behavioral: Food Allergy Elimination + Willis Exercise Sponsor:   Galveston Clinical Research Foundation Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D6FpU9

AQUApay (AQUA Predictive Ability in Youths): Study on the Predictive Ability of the Questionnaire AQUA © in Children and Adolescents

Condition:   Young Athletes Intervention:   Diagnostic Test: Questionnaire AQUA©, pediatric version Sponsor:   Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S5ScAB

Vaccination Coverage and Level of Protection in Patients at Risk

Conditions:   Diabetes;   Chronic Kidney Disease;   Allergy;   Cystic Fibrosis;   Heart Disease Intervention:   Sponsor:   Universitaire Ziekenhuizen Leuven Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D6EF1j

Blood Sampling of Healthy Volunteers for Immunological Research

Condition:   Healthy Volunteers Intervention:   Other: Blood sample Sponsor:   The Netherlands Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S7FYr9

A Phase 1b Study of STMC-103H in Multi-Sensitized Allergic Subjects Who Are Otherwise Healthy

Condition:   Atopic Immunoglobulin E-Mediated Allergic Disorder Interventions:   Biological: STMC-103H;   Biological: Placebo Sponsors:   Siolta Therapeutics, Inc.;   Integrium Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D2JZTE

Diagnostic Equivalence of the Skin Prick Test Tape vs. Conventional Skin PrickTest

Conditions:   Allergic Rhinitis;   Allergic Asthma;   Allergic Conjunctivitis;   Food Allergy Interventions:   Diagnostic Test: Skin Prick Test;   Diagnostic Test: Skin Prick Test TAPE Sponsor:   Prof. Dr. Claus Bachert BVBA Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S4twJ1

Study to Evaluate the Efficacy and Safety of " Allergovac Poliplus " in Polysensitized Patients With Allergic Rhinitis/Rhinoconjunctivitis, With or Without Asthma

Conditions:   Rhinitis, Allergic;   Rhinoconjunctivitis Intervention:   Biological: Allergen Immunotherapy (AIT) Sponsor:   Roxall Medicina España S.A Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D41VNJ

Pharmacokinetic Study to Evaluate Double-Dose Levonorgestrel Emergency Contraception in Combination With Efavirenz-Based Antiretroviral Therapy or Rifampicin-Containing Anti-Tuberculosis Therapy

Conditions:   HIV Infections;   Tuberculosis Intervention:   Drug: Levonorgestrel Emergency Contraception (LNG EC) Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S66HEM

Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies

Conditions:   Bone Marrow Transplant Complications;   Graft Versus Host Disease;   Infection Viral;   Engraft Failure;   Immunologic Suppression Interventions:   Drug: Cyclophosphamide;   Drug: ATG Sponsor:   Hospital Israelita Albert Einstein Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D5BAP8

Swedish Study of Immunotherapy for Milk Allergy in Children

Condition:   Milk Allergy Intervention:   Other: Milk protein in fresh milk Sponsor:   Umeå University Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SamaDB

Siderophore-profile in Allergic and Non-allergic Subjects

Conditions:   Allergy;   Healthy;   Allergic Sensitisation Intervention:   Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D513Iw

Immunogenicity and Safety Study of Inactivated Subunit H5N1 Influenza Vaccine in Prior Recipients of Live Attenuated H2N2, H6N1 and H9N2 Influenza Vaccines and in H5N1 and Live Attenuated Vaccine Na ïve Individuals

Condition:   Influenza Intervention:   Biological: H5N1 pISV Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S7FWQ3

Iron and Pollen Allergy in Women

Conditions:   Allergy Pollen;   Healthy Interventions:   Dietary Supplement: ImmunoBon;   Dietary Supplement: Placebo Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D7rjlo

Zoledronate Treatment Duration Is Linked to Bisphosphonate‐Related ONJ Prevalence in Rice Rats with Generalized Periodontitis

Abstract

Objectives

To determine the extent that zoledronate (ZOL) dose and duration is associated with bisphosphonate‐related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with generalized periodontitis (PD); characterize structural and tissue‐level features of BRONJ‐like lesions in this model; and examine the specific anti‐resorptive role of ZOL in BRONJ.

Materials and Methods

Rice rats (n=228) consumed high‐sucrose‐casein diet to enhance generalized PD. Groups of rats received 0, 8, 20, 50 or 125μg/kg IV ZOL/4wks encompassing osteoporosis and oncology ZOL doses. Rats from each dose group (n=9‐16) were necropsied after 12, 18, 24, and 30wks of treatment. BRONJ‐like lesion prevalence and tissue‐level features were assessed grossly, histopathologically, and by MicroCT. ZOL bone turnover effects were assessed by femoral pQCT, serum bone‐turnover marker ELISAs, and osteoclast immunolabeling.

Results

Prevalence of BRONJ‐like lesions was significantly associated with 1) ZOL treatment duration, but plateaued at the lowest oncologic dose, and 2) there was a similar dose‐related plateau in the systemic anti‐resorptive effect of ZOL. ZOL and BRONJ‐like lesions also altered the structural and tissue‐level features of the jaw.

Conclusion

The relationship between BRONJ‐like lesion prevalence and ZOL dose and duration varies depending on the co‐ or pre‐existing oral risk factor. At clinically relevant doses of ZOL, BRONJ‐like lesions are associated with anti‐resorptive activity.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BjViGT

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Conditions:   Pulmonary Invasive Mold Infections;   Pulmonary Invasive Aspergillosis Intervention:   Diagnostic Test: Non-Invasive Testing for PIMI Sponsors:   Duke University;   Children's Hospital of Philadelphia;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S5Gaal

Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet

Conditions:   Intervention;   Food Allergy;   Food Preferences;   Food Intolerance;   Diet Habit;   Diet Modification Intervention:   Behavioral: Multicomponent intervention Sponsors:   University Rovira i Virgili;   Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D41YsT

Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population

Conditions:   Hepatitis E;   Immunisation Interventions:   Biological: HEV 239;   Other: Placebo Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S8gRVm

Retrospective Chart Review of Candida Fungemia

Condition:   Candida Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S62j8D

Food Allergen Eliminations and Combined Protocols for Obesity Reduction: a Preliminary Comparison Study

Condition:   Obesity Intervention:   Behavioral: Food Allergy Elimination + Willis Exercise Sponsor:   Galveston Clinical Research Foundation Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D6FpU9

AQUApay (AQUA Predictive Ability in Youths): Study on the Predictive Ability of the Questionnaire AQUA © in Children and Adolescents

Condition:   Young Athletes Intervention:   Diagnostic Test: Questionnaire AQUA©, pediatric version Sponsor:   Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S5ScAB

Vaccination Coverage and Level of Protection in Patients at Risk

Conditions:   Diabetes;   Chronic Kidney Disease;   Allergy;   Cystic Fibrosis;   Heart Disease Intervention:   Sponsor:   Universitaire Ziekenhuizen Leuven Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D6EF1j

Blood Sampling of Healthy Volunteers for Immunological Research

Condition:   Healthy Volunteers Intervention:   Other: Blood sample Sponsor:   The Netherlands Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S7FYr9

A Phase 1b Study of STMC-103H in Multi-Sensitized Allergic Subjects Who Are Otherwise Healthy

Condition:   Atopic Immunoglobulin E-Mediated Allergic Disorder Interventions:   Biological: STMC-103H;   Biological: Placebo Sponsors:   Siolta Therapeutics, Inc.;   Integrium Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D2JZTE

Diagnostic Equivalence of the Skin Prick Test Tape vs. Conventional Skin PrickTest

Conditions:   Allergic Rhinitis;   Allergic Asthma;   Allergic Conjunctivitis;   Food Allergy Interventions:   Diagnostic Test: Skin Prick Test;   Diagnostic Test: Skin Prick Test TAPE Sponsor:   Prof. Dr. Claus Bachert BVBA Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S4twJ1

Study to Evaluate the Efficacy and Safety of " Allergovac Poliplus " in Polysensitized Patients With Allergic Rhinitis/Rhinoconjunctivitis, With or Without Asthma

Conditions:   Rhinitis, Allergic;   Rhinoconjunctivitis Intervention:   Biological: Allergen Immunotherapy (AIT) Sponsor:   Roxall Medicina España S.A Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D41VNJ

Pharmacokinetic Study to Evaluate Double-Dose Levonorgestrel Emergency Contraception in Combination With Efavirenz-Based Antiretroviral Therapy or Rifampicin-Containing Anti-Tuberculosis Therapy

Conditions:   HIV Infections;   Tuberculosis Intervention:   Drug: Levonorgestrel Emergency Contraception (LNG EC) Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S66HEM

Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies

Conditions:   Bone Marrow Transplant Complications;   Graft Versus Host Disease;   Infection Viral;   Engraft Failure;   Immunologic Suppression Interventions:   Drug: Cyclophosphamide;   Drug: ATG Sponsor:   Hospital Israelita Albert Einstein Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D5BAP8

Swedish Study of Immunotherapy for Milk Allergy in Children

Condition:   Milk Allergy Intervention:   Other: Milk protein in fresh milk Sponsor:   Umeå University Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SamaDB

Siderophore-profile in Allergic and Non-allergic Subjects

Conditions:   Allergy;   Healthy;   Allergic Sensitisation Intervention:   Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D513Iw

Immunogenicity and Safety Study of Inactivated Subunit H5N1 Influenza Vaccine in Prior Recipients of Live Attenuated H2N2, H6N1 and H9N2 Influenza Vaccines and in H5N1 and Live Attenuated Vaccine Na ïve Individuals

Condition:   Influenza Intervention:   Biological: H5N1 pISV Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S7FWQ3

Iron and Pollen Allergy in Women

Conditions:   Allergy Pollen;   Healthy Interventions:   Dietary Supplement: ImmunoBon;   Dietary Supplement: Placebo Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D7rjlo

Zoledronate Treatment Duration Is Linked to Bisphosphonate‐Related ONJ Prevalence in Rice Rats with Generalized Periodontitis

Abstract

Objectives

To determine the extent that zoledronate (ZOL) dose and duration is associated with bisphosphonate‐related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with generalized periodontitis (PD); characterize structural and tissue‐level features of BRONJ‐like lesions in this model; and examine the specific anti‐resorptive role of ZOL in BRONJ.

Materials and Methods

Rice rats (n=228) consumed high‐sucrose‐casein diet to enhance generalized PD. Groups of rats received 0, 8, 20, 50 or 125μg/kg IV ZOL/4wks encompassing osteoporosis and oncology ZOL doses. Rats from each dose group (n=9‐16) were necropsied after 12, 18, 24, and 30wks of treatment. BRONJ‐like lesion prevalence and tissue‐level features were assessed grossly, histopathologically, and by MicroCT. ZOL bone turnover effects were assessed by femoral pQCT, serum bone‐turnover marker ELISAs, and osteoclast immunolabeling.

Results

Prevalence of BRONJ‐like lesions was significantly associated with 1) ZOL treatment duration, but plateaued at the lowest oncologic dose, and 2) there was a similar dose‐related plateau in the systemic anti‐resorptive effect of ZOL. ZOL and BRONJ‐like lesions also altered the structural and tissue‐level features of the jaw.

Conclusion

The relationship between BRONJ‐like lesion prevalence and ZOL dose and duration varies depending on the co‐ or pre‐existing oral risk factor. At clinically relevant doses of ZOL, BRONJ‐like lesions are associated with anti‐resorptive activity.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BjViGT

Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis

Publication date: Available online 2 February 2019

Source: Journal of Oral Biology and Craniofacial Research

Author(s): Shalini Kaushal, Anita Kumari Singh, Nand Lal, Siddharth K. Das, Abbas Ali Mahdi

Abstract

Background

Evidence have been proposed a positive association between severity of Periodontitis and Rheumatoid arthritis (RA) activity, individuals with advanced RA are more likely to develop periodontal problems compared to their non-RA counterparts, and vice versa. Studies have been suggested that RA manifest as a result of an inflammatory imbalance and autoimmunity. In this perspective, treatment modalities that lead to inhibition of proinflammatory mediators, may prove beneficial for reducing the severity of RA. This study examined the effects of non surgical periodontal therapy (NSPT) on disease activity of RA.

Methods

Diagnosed patients of active rheumatoid arthritis with chronic periodontitis were recruited in this study and divided in to treatment and controls groups, both groups were similar in all demographics assessed. Treatment group (n = 20) and controls group (n = 20) underwent assessment for periodontal clinical parameters (plaque index, gingival index, probing pocket depth, clinical attachment level), Rheumatologic clinical (simplified disease activity index) and biochemical parameters(C-reactive protein, Rheumatoid factor, Anti-cyclic citrullinated protein) at baseline and 8 weeks. Serum levels of biochemical parameters were measured by enzyme-linked immunosorbent assay (ELISA).

Results

The statistically significant (p < 0.001) reduction observed in mean values of PI, GI, PPD, CAL, SDAI in treatment group at 8weeks after NSPT as compare to control group. However serum level of ACCPA, CRP and RF did not show statistically significant (p > 0.05) changes from baseline to reassessment (8 weeks) in both groups.

Conclusions

The improvement in RA disease activity may occurs after non surgical periodontal therapy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HWziI2

Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis

Publication date: Available online 2 February 2019

Source: Journal of Oral Biology and Craniofacial Research

Author(s): Shalini Kaushal, Anita Kumari Singh, Nand Lal, Siddharth K. Das, Abbas Ali Mahdi

Abstract

Background

Evidence have been proposed a positive association between severity of Periodontitis and Rheumatoid arthritis (RA) activity, individuals with advanced RA are more likely to develop periodontal problems compared to their non-RA counterparts, and vice versa. Studies have been suggested that RA manifest as a result of an inflammatory imbalance and autoimmunity. In this perspective, treatment modalities that lead to inhibition of proinflammatory mediators, may prove beneficial for reducing the severity of RA. This study examined the effects of non surgical periodontal therapy (NSPT) on disease activity of RA.

Methods

Diagnosed patients of active rheumatoid arthritis with chronic periodontitis were recruited in this study and divided in to treatment and controls groups, both groups were similar in all demographics assessed. Treatment group (n = 20) and controls group (n = 20) underwent assessment for periodontal clinical parameters (plaque index, gingival index, probing pocket depth, clinical attachment level), Rheumatologic clinical (simplified disease activity index) and biochemical parameters(C-reactive protein, Rheumatoid factor, Anti-cyclic citrullinated protein) at baseline and 8 weeks. Serum levels of biochemical parameters were measured by enzyme-linked immunosorbent assay (ELISA).

Results

The statistically significant (p < 0.001) reduction observed in mean values of PI, GI, PPD, CAL, SDAI in treatment group at 8weeks after NSPT as compare to control group. However serum level of ACCPA, CRP and RF did not show statistically significant (p > 0.05) changes from baseline to reassessment (8 weeks) in both groups.

Conclusions

The improvement in RA disease activity may occurs after non surgical periodontal therapy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HWziI2

Pediatric Anesthesia: A Problem-Based Learning Approach

No abstract available

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WDeE2N

Pediatric Anesthesia: A Problem-Based Learning Approach

No abstract available

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WDeE2N

Correlations between MDCT features and clinicopathological findings of primary adrenal lymphoma

Publication date: Available online 2 February 2019

Source: European Journal of Radiology

Author(s): Ling yang, Mengni Zhang, Shuang Zhao, Yajun Hu, Jin Yao

ABSTRACT

Objective

To investigate the MDCT features of primary adrenal lymphoma (PAL) and correlate the results with clinicopathological findings.

Materials and Methods

Twenty eight patients (17 men, 11 women; median age, 61.5years) with pathologically confirmed PAL were included in this study. MDCT features of the lesions were retrospectively reviewed and correlated with clinicopathological findings.

Results

All of the 28 cases were non-Hodgkin's lymphoma (NHL), in which 25 cases were diffuse large B-cell lymphoma and 3 cases T-cell lymphoma. 21 (75%) patients had bilateral tumors with maximum diameter of 3.9-17.7 cm (median, 9.18 cm), and 7 (25%) patients had unilateral tumors with maximum diameter of 4.3-14.9 cm (median, 8.6 cm). The sign of infiltrating adjacent organs and encasing adjacent vessels were appeared in 10 and 15 patients respectively, in which 9 patients had both signs. 20 (71.4%) patients had the appearance of adeniform, and 3 (10.7%) patients showed infiltrating and embedding the adrenal gland. Among all the patients, 27 (96.4%) and 26 (92.9%) patients had mild enhancement on arterial and parenchymal phase, respectively; and 12 (42.8%) were homogenous, 14 (50%) slightly inhomogeneous and 2 (7.1%) heterogeneous on both phase. In addition, adrenal insufficiency was found in 33.3% (7/21) of the patients with bilateral lesions, and none in unilateral lesions.

Conclusion

Large adrenal soft tissue mass with maintenance of adreniform shape, encasing vessels, homogenous or slightly inhomogeneous density with no calcification, and mild enhancement on both arterial and parenchymal phase could be seen as the main MDCT features of PAL. In addition, infiltrating and embedding the adrenal gland may be specific imaging characteristics of PAL.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t4yYMW

Correlations between MDCT features and clinicopathological findings of primary adrenal lymphoma

Publication date: Available online 2 February 2019

Source: European Journal of Radiology

Author(s): Ling yang, Mengni Zhang, Shuang Zhao, Yajun Hu, Jin Yao

ABSTRACT

Objective

To investigate the MDCT features of primary adrenal lymphoma (PAL) and correlate the results with clinicopathological findings.

Materials and Methods

Twenty eight patients (17 men, 11 women; median age, 61.5years) with pathologically confirmed PAL were included in this study. MDCT features of the lesions were retrospectively reviewed and correlated with clinicopathological findings.

Results

All of the 28 cases were non-Hodgkin's lymphoma (NHL), in which 25 cases were diffuse large B-cell lymphoma and 3 cases T-cell lymphoma. 21 (75%) patients had bilateral tumors with maximum diameter of 3.9-17.7 cm (median, 9.18 cm), and 7 (25%) patients had unilateral tumors with maximum diameter of 4.3-14.9 cm (median, 8.6 cm). The sign of infiltrating adjacent organs and encasing adjacent vessels were appeared in 10 and 15 patients respectively, in which 9 patients had both signs. 20 (71.4%) patients had the appearance of adeniform, and 3 (10.7%) patients showed infiltrating and embedding the adrenal gland. Among all the patients, 27 (96.4%) and 26 (92.9%) patients had mild enhancement on arterial and parenchymal phase, respectively; and 12 (42.8%) were homogenous, 14 (50%) slightly inhomogeneous and 2 (7.1%) heterogeneous on both phase. In addition, adrenal insufficiency was found in 33.3% (7/21) of the patients with bilateral lesions, and none in unilateral lesions.

Conclusion

Large adrenal soft tissue mass with maintenance of adreniform shape, encasing vessels, homogenous or slightly inhomogeneous density with no calcification, and mild enhancement on both arterial and parenchymal phase could be seen as the main MDCT features of PAL. In addition, infiltrating and embedding the adrenal gland may be specific imaging characteristics of PAL.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t4yYMW

Cockroach allergens – coping with challenging complexity

Publication date: Available online 2 February 2019

Source: Journal of Allergy and Clinical Immunology

Author(s): Jörg Kleine-Tebbe, Robert G. Hamilton, Richard E. Goodman

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tt4hN5

Mining Social Media Data to Assess the Risk of Skin and Soft Tissue Infections from Allergen Immunotherapy

Publication date: Available online 2 February 2019

Source: Journal of Allergy and Clinical Immunology

Author(s): Kimberly G. Blumenthal, Maxim Topaz, Li Zhou, Tyler Harkness, Roee Sa'adon, Ofrit Bar-Bachar, Aidan A. Long

Abstract

Background

Allergen immunotherapy (AIT) treatment for allergic rhinitis and asthma is used by 2.6 million Americans annually. Clinical and sterility testing studies identify no risk of contamination or infection from extracts prepared using recommended aseptic techniques, but regulatory concerns persist. Social media can be used to investigate rare adverse effects not captured by traditional studies.

Objective

To investigate large social media databases for suggestion of AIT skin and soft tissue infection (SSTI) risk and compare this risk to a comparator procedure with a sterile pharmaceutical.

Methods

We analyzed USA-restricted data from over 10 common text-based social media platforms including Facebook, Twitter, and Reddit between 2012-2016. We employed natural language processing (NLP) to identify posts related to AIT and, separately, Influenza vaccination (comparator procedure). NLP was followed by manual review to identify posts suggesting a possible SSTI associated with either AIT or Influenza vaccination. SSTI frequencies with 95% confidence intervals (CI) were compared.

Results

We identified 25,126 AIT posts, which were matched by social media platform to 25,126 Influenza vaccination-related posts. NLP identified 4,088 (16.3%) AIT posts that required manual review, with 6 posts (0.02%, 95%CI 0.005% to 0.043%) indicative of possible AIT-related SSTI. NLP identified 2,689 (10.7%) Influenza posts that required manual review, with 7 posts (0.03%, 95%CI 0.007% to 0.048%) indicative of possible Influenza vaccination-related SSTI.

Conclusion

Social media data suggest that SSTI from AIT and Influenza vaccination are equally rare events. Given that AIT's SSTI risk appears comparable to the risk using a sterile pharmaceutical based on social media data, current aseptic technique procedures seem safe.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BjMKjh

Regulation of Ectodomain Shedding of ADAM33 In Vitro and In Vivo

Publication date: Available online 2 February 2019

Source: Journal of Allergy and Clinical Immunology

Author(s): Elizabeth R. Davies, Laura Denney, Marieke Wandel, Clare M. Lloyd, Donna E. Davies, Hans Michael Haitchi

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TubjRs

Cockroach allergens – coping with challenging complexity

Publication date: Available online 2 February 2019

Source: Journal of Allergy and Clinical Immunology

Author(s): Jörg Kleine-Tebbe, Robert G. Hamilton, Richard E. Goodman

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tt4hN5

Mining Social Media Data to Assess the Risk of Skin and Soft Tissue Infections from Allergen Immunotherapy

Publication date: Available online 2 February 2019

Source: Journal of Allergy and Clinical Immunology

Author(s): Kimberly G. Blumenthal, Maxim Topaz, Li Zhou, Tyler Harkness, Roee Sa'adon, Ofrit Bar-Bachar, Aidan A. Long

Abstract

Background

Allergen immunotherapy (AIT) treatment for allergic rhinitis and asthma is used by 2.6 million Americans annually. Clinical and sterility testing studies identify no risk of contamination or infection from extracts prepared using recommended aseptic techniques, but regulatory concerns persist. Social media can be used to investigate rare adverse effects not captured by traditional studies.

Objective

To investigate large social media databases for suggestion of AIT skin and soft tissue infection (SSTI) risk and compare this risk to a comparator procedure with a sterile pharmaceutical.

Methods

We analyzed USA-restricted data from over 10 common text-based social media platforms including Facebook, Twitter, and Reddit between 2012-2016. We employed natural language processing (NLP) to identify posts related to AIT and, separately, Influenza vaccination (comparator procedure). NLP was followed by manual review to identify posts suggesting a possible SSTI associated with either AIT or Influenza vaccination. SSTI frequencies with 95% confidence intervals (CI) were compared.

Results

We identified 25,126 AIT posts, which were matched by social media platform to 25,126 Influenza vaccination-related posts. NLP identified 4,088 (16.3%) AIT posts that required manual review, with 6 posts (0.02%, 95%CI 0.005% to 0.043%) indicative of possible AIT-related SSTI. NLP identified 2,689 (10.7%) Influenza posts that required manual review, with 7 posts (0.03%, 95%CI 0.007% to 0.048%) indicative of possible Influenza vaccination-related SSTI.

Conclusion

Social media data suggest that SSTI from AIT and Influenza vaccination are equally rare events. Given that AIT's SSTI risk appears comparable to the risk using a sterile pharmaceutical based on social media data, current aseptic technique procedures seem safe.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BjMKjh