Efficacy of axillary versus infraclavicular brachial plexus block in preventing tourniquet pain: A randomised trial

BACKGROUND Axillary and infraclavicular brachial plexus blocks are commonly used for upper limb surgery. Clinicians require information on the relative benefits of each to make a rational selection for specific patients and procedures. OBJECTIVES The main objective of the study was to compare axillary and infraclavicular brachial plexus block in terms of the incidence and severity of tourniquet pain. DESIGN Single blinded, randomised trial. SETTING University affiliated hospital, level-1 trauma centre. PATIENTS Age more than 18 years, ASAI-III patients undergoing orthopaedic surgery distal to the elbow, with an anticipated tourniquet duration of more than 45 min were recruited. INTERVENTIONS Patients underwent either ultrasound guided axillary brachial plexus block or infraclavicular block (ICB). MAIN OUTCOME MEASURES Incidence of tourniquet pain (onset, severity, associated haemodynamic changes) and block characteristics (block performance/onset times, distribution, incidence of adverse events, patient satisfaction) were recorded. RESULTS Eighty two patients (40 in the axillary block and 42 in the ICB group) were recruited. The incidence (5/36 and 3/35; P = 0.71), onset time mean (SD) were 73.0 (14.8) and 86.6 (5.7) min (P = 0.18) and severity (mild/moderate; 4/1 and 1/2; P = 0.51) of tourniquet pain were similar in the two groups. The incidence of paraesthesia during block performance, and block performance time were greater in the axillary block group (P = 0.0054 and 0.012, respectively). The volume of local anaesthetic administered was greater in the ICB group (P 

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American College of Allergy, Asthma & amp; Immunology, Nov. 15-19

The 2018 Annual Meeting of the American College of Allergy, Asthma& Immunology The annual meeting of the American College of Allergy, Asthma& Immunology was held from Nov. 15 to 19 in Seattle and attracted approximately 3,500 participants... (Source: Drugs.com - Pharma News)

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Efficacy of axillary versus infraclavicular brachial plexus block in preventing tourniquet pain: A randomised trial

BACKGROUND Axillary and infraclavicular brachial plexus blocks are commonly used for upper limb surgery. Clinicians require information on the relative benefits of each to make a rational selection for specific patients and procedures. OBJECTIVES The main objective of the study was to compare axillary and infraclavicular brachial plexus block in terms of the incidence and severity of tourniquet pain. DESIGN Single blinded, randomised trial. SETTING University affiliated hospital, level-1 trauma centre. PATIENTS Age more than 18 years, ASAI-III patients undergoing orthopaedic surgery distal to the elbow, with an anticipated tourniquet duration of more than 45 min were recruited. INTERVENTIONS Patients underwent either ultrasound guided axillary brachial plexus block or infraclavicular block (ICB). MAIN OUTCOME MEASURES Incidence of tourniquet pain (onset, severity, associated haemodynamic changes) and block characteristics (block performance/onset times, distribution, incidence of adverse events, patient satisfaction) were recorded. RESULTS Eighty two patients (40 in the axillary block and 42 in the ICB group) were recruited. The incidence (5/36 and 3/35; P = 0.71), onset time mean (SD) were 73.0 (14.8) and 86.6 (5.7) min (P = 0.18) and severity (mild/moderate; 4/1 and 1/2; P = 0.51) of tourniquet pain were similar in the two groups. The incidence of paraesthesia during block performance, and block performance time were greater in the axillary block group (P = 0.0054 and 0.012, respectively). The volume of local anaesthetic administered was greater in the ICB group (P 

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Bps5e7

American College of Allergy, Asthma & amp; Immunology, Nov. 15-19

The 2018 Annual Meeting of the American College of Allergy, Asthma& Immunology The annual meeting of the American College of Allergy, Asthma& Immunology was held from Nov. 15 to 19 in Seattle and attracted approximately 3,500 participants... (Source: Drugs.com - Pharma News)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Kn35qS

American College of Allergy, Asthma & amp; Immunology, Nov. 15-19

The 2018 Annual Meeting of the American College of Allergy, Asthma& Immunology The annual meeting of the American College of Allergy, Asthma& Immunology was held from Nov. 15 to 19 in Seattle and attracted approximately 3,500 participants... (Source: Drugs.com - Pharma News)

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Utility of Skin Biopsy and Culture in the Diagnosis and Classification of Chronic Ulcers: A Single-Institution, Retrospective Study

Abstract: In the United States, chronic ulcers affect 6.5 million people, with a cost of ≈$20 million annually. The most common etiology of chronic ulcers in the United States is venous stasis, followed by arterial insufficiency and neuropathic ulcers. Less common causes of chronic ulcers include infection, inflammatory etiologies such as vasculitis and pyoderma gangrenosum, and neoplastic causes. Obtaining skin biopsy and tissue culture can be helpful in diagnosing unusual causes of chronic ulcers; however, there are little data on the diagnostic utility of skin biopsy in rendering a definitive diagnosis of the etiology of chronic ulcers. A retrospective study of all skin ulcers biopsied during a 10-year period at the University of Washington was undertaken. Re-excisions and surgical wounds were excluded. A total of 270 ulcer biopsy specimens were included. In 48% of cases, no specific diagnosis could be rendered histologically. 44.8% of chronic ulcers biopsied were due to atypical causes, with neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma, and cutaneous T-cell lymphoma) being the most common. Vasculitis and pyoderma gangrenosum each represented 1.5% of rendered diagnoses. Concomitant skin culture was performed in 28.9% of cases, and special stains [acid-fast bacilli, Brown and Brenn (B&B), Grocott's methenamine silver, and periodic acid-Schiff stains] were performed in 34.0%. Although more than half (49 of 78) of tissue cultures were positive, only 6.8% (12 of 175) of special stains on tissue sections were positive. We conclude that although the etiology of many ulcers cannot be determined by routine histology alone, skin biopsy of ulcers remains a critical part of the workup given that when a specific cause can be determined, atypical etiologies, including neoplasms, represent a significant proportion of chronic ulcers. Limitations of our study include referral bias. Our results also confirm the higher diagnostic yield of conventional tissue culture compared with special tissue stain biopsies of skin ulcers. Correspondence: Shiva Khoobyari, MD, Department of Pathology, University of Washington Medical Center, Box 357470, 1959 NE Pacific Street, Seattle, WA 98195 (e-mail: Skhoob@uw.edu) S. Khoobyari and T. I. Miller had equal contribution. The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Concurrent Metastatic Merkel Cell Carcinoma and Cutaneous Squamous Cell Carcinoma in the Same Lymph Node

Abstract: The coexistence of Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC) in the same cutaneous lesion is well known. The pathogenesis is believed to be distinct from conventional polyomavirus-related MCC, and it has a more aggressive course. Metastasis of MCC and SCC to the same lymph node is exceedingly rare with only one previously reported case in the English literature. To the best of our knowledge, this is the second case of MCC and SCC with metastasis to the same lymph node. Our case demonstrates the aggressive nature of the combined MCC and SCC in the setting of immunosuppression. Correspondence: Lubna Suaiti, MBChB, MSc, Department of Pathology/Dermatopathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1072 (e-mail: lsuaiti@gmail.com). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Linear IgA Bullous Dermatosis Preceding the Diagnosis of Primary Sclerosing Cholangitis and Ulcerative Colitis: A Case Report

Abstract: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder seen in the pediatric and adult populations that is often linked to a medication, infection, or underlying gastrointestinal, hepatobiliary, or autoimmune disease. In this study, we describe the case of a 23-year-old white man whose presentation and diagnosis of LABD ultimately led to the discovery of underlying primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). His dermatitis resolved with topical steroids and dapsone, and he is undergoing systemic treatment for his UC and PSC. This exceptional case further validates the association between LABD with UC, strengthens that with PSC, and underscores the importance of alerting clinicians to consider conducting a systemic workup in addition to thorough medication history on making the diagnosis of LABD. Correspondence: Jaroslaw Jedrych, MD, PhD, UPMC Dermatology, 3708 Fifth Avenue Fifth Floor, Suite 500.68, Pittsburgh, PA 15213 (e-mail: jedrychj@upmc.edu). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Late-Onset Nevus Comedonicus With Follicular Epidermolytic Hyperkeratosis—Case Report and Review of the Literature

Abstract: Nevus comedonicus is a rare cutaneous follicular hamartoma, characterized by the clustering of papules with firm, blackened horny buffers. It is usually present at birth or during childhood, although few cases of late-onset disease have been described. We present a case of postmenopausal-onset nevus comedonicus in a 55-year-old white woman without relevant medical history. Skin biopsy showed the typical features of several cyst-dilated follicular structures occupied by keratotic material and the peculiar finding of epidermolytic hyperkeratosis of the follicular epithelial walls. A brief review of the clinical and histological features of other similar cases published in the literature is performed. Correspondence: Ramona Zanniello, MD, Section of Dermatology, University of Cagliari, via Ospedale 54, 09124 Cagliari, Italy (e-mail: ramonazanniello@gmail.com). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Positive Antinucleolar Antibodies on Direct Immunofluorescence of Lesional Skin of a Patient With Limited Systemic Sclerosis

No abstract available

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Proliferating Neurocristic Hamartoma Arising in a Giant Congenital Nevus: Comparative Genomic Hybridization Findings

Abstract: Neurocristic cutaneous hamartomas (NCHs) are rarely reported tumors with divergent differentiation derived from persistently active pluripotent cells from the neural crest. They result from aberrant development of the neuromesenchyme, and they can express fibrogenic, melanocytic, and/or neurosustentacular differentiation. Thus, congenital melanocytic nevus also represents a neurocristic dysplasia of the skin in which cells are melanogenic cells arrested in development located in the reticular dermis, and nodular proliferative neurocristic hamartoma may arise within a congenital melanocytic nevus. The real importance of NCHs is that, although few cases have been reported in the literature, some cases have shown development of melanoma. Moreover, the only previously reported case of a similar "proliferative neurocristic nodule" analyzed with comparative genomic hybridization showed an aberration pattern similar to melanoma. We present a rare case of NCH associated with a congenital nevus in a 7-year-old boy, with classical histological and immunohistochemical features suggesting a "proliferative neurocristic hamartoma". Comparative genomic hybridization assay showed that chromosomal aberrations were absent in the congenital nevus, whereas, interestingly, the proliferative neurocristic proliferation had an aberration pattern similar to proliferative nodules with gains or losses of entire chromosomes only, similar to typical proliferative nodules and supporting the benign behavior of this lesion. Correspondence: Maria Concepcion Garrido, MD, PhD, Dpto. de Anatomía Patológica, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n, 28041 Madrid, Spain (e-mail: mariagarridoruiz@gmail.com). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Bprglx

Utility of Skin Biopsy and Culture in the Diagnosis and Classification of Chronic Ulcers: A Single-Institution, Retrospective Study

Abstract: In the United States, chronic ulcers affect 6.5 million people, with a cost of ≈$20 million annually. The most common etiology of chronic ulcers in the United States is venous stasis, followed by arterial insufficiency and neuropathic ulcers. Less common causes of chronic ulcers include infection, inflammatory etiologies such as vasculitis and pyoderma gangrenosum, and neoplastic causes. Obtaining skin biopsy and tissue culture can be helpful in diagnosing unusual causes of chronic ulcers; however, there are little data on the diagnostic utility of skin biopsy in rendering a definitive diagnosis of the etiology of chronic ulcers. A retrospective study of all skin ulcers biopsied during a 10-year period at the University of Washington was undertaken. Re-excisions and surgical wounds were excluded. A total of 270 ulcer biopsy specimens were included. In 48% of cases, no specific diagnosis could be rendered histologically. 44.8% of chronic ulcers biopsied were due to atypical causes, with neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma, and cutaneous T-cell lymphoma) being the most common. Vasculitis and pyoderma gangrenosum each represented 1.5% of rendered diagnoses. Concomitant skin culture was performed in 28.9% of cases, and special stains [acid-fast bacilli, Brown and Brenn (B&B), Grocott's methenamine silver, and periodic acid-Schiff stains] were performed in 34.0%. Although more than half (49 of 78) of tissue cultures were positive, only 6.8% (12 of 175) of special stains on tissue sections were positive. We conclude that although the etiology of many ulcers cannot be determined by routine histology alone, skin biopsy of ulcers remains a critical part of the workup given that when a specific cause can be determined, atypical etiologies, including neoplasms, represent a significant proportion of chronic ulcers. Limitations of our study include referral bias. Our results also confirm the higher diagnostic yield of conventional tissue culture compared with special tissue stain biopsies of skin ulcers. Correspondence: Shiva Khoobyari, MD, Department of Pathology, University of Washington Medical Center, Box 357470, 1959 NE Pacific Street, Seattle, WA 98195 (e-mail: Skhoob@uw.edu) S. Khoobyari and T. I. Miller had equal contribution. The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Concurrent Metastatic Merkel Cell Carcinoma and Cutaneous Squamous Cell Carcinoma in the Same Lymph Node

Abstract: The coexistence of Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC) in the same cutaneous lesion is well known. The pathogenesis is believed to be distinct from conventional polyomavirus-related MCC, and it has a more aggressive course. Metastasis of MCC and SCC to the same lymph node is exceedingly rare with only one previously reported case in the English literature. To the best of our knowledge, this is the second case of MCC and SCC with metastasis to the same lymph node. Our case demonstrates the aggressive nature of the combined MCC and SCC in the setting of immunosuppression. Correspondence: Lubna Suaiti, MBChB, MSc, Department of Pathology/Dermatopathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1072 (e-mail: lsuaiti@gmail.com). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Boe9Ry

Linear IgA Bullous Dermatosis Preceding the Diagnosis of Primary Sclerosing Cholangitis and Ulcerative Colitis: A Case Report

Abstract: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder seen in the pediatric and adult populations that is often linked to a medication, infection, or underlying gastrointestinal, hepatobiliary, or autoimmune disease. In this study, we describe the case of a 23-year-old white man whose presentation and diagnosis of LABD ultimately led to the discovery of underlying primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). His dermatitis resolved with topical steroids and dapsone, and he is undergoing systemic treatment for his UC and PSC. This exceptional case further validates the association between LABD with UC, strengthens that with PSC, and underscores the importance of alerting clinicians to consider conducting a systemic workup in addition to thorough medication history on making the diagnosis of LABD. Correspondence: Jaroslaw Jedrych, MD, PhD, UPMC Dermatology, 3708 Fifth Avenue Fifth Floor, Suite 500.68, Pittsburgh, PA 15213 (e-mail: jedrychj@upmc.edu). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Kl4oX1

Late-Onset Nevus Comedonicus With Follicular Epidermolytic Hyperkeratosis—Case Report and Review of the Literature

Abstract: Nevus comedonicus is a rare cutaneous follicular hamartoma, characterized by the clustering of papules with firm, blackened horny buffers. It is usually present at birth or during childhood, although few cases of late-onset disease have been described. We present a case of postmenopausal-onset nevus comedonicus in a 55-year-old white woman without relevant medical history. Skin biopsy showed the typical features of several cyst-dilated follicular structures occupied by keratotic material and the peculiar finding of epidermolytic hyperkeratosis of the follicular epithelial walls. A brief review of the clinical and histological features of other similar cases published in the literature is performed. Correspondence: Ramona Zanniello, MD, Section of Dermatology, University of Cagliari, via Ospedale 54, 09124 Cagliari, Italy (e-mail: ramonazanniello@gmail.com). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Positive Antinucleolar Antibodies on Direct Immunofluorescence of Lesional Skin of a Patient With Limited Systemic Sclerosis

No abstract available

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KmgoaN

Proliferating Neurocristic Hamartoma Arising in a Giant Congenital Nevus: Comparative Genomic Hybridization Findings

Abstract: Neurocristic cutaneous hamartomas (NCHs) are rarely reported tumors with divergent differentiation derived from persistently active pluripotent cells from the neural crest. They result from aberrant development of the neuromesenchyme, and they can express fibrogenic, melanocytic, and/or neurosustentacular differentiation. Thus, congenital melanocytic nevus also represents a neurocristic dysplasia of the skin in which cells are melanogenic cells arrested in development located in the reticular dermis, and nodular proliferative neurocristic hamartoma may arise within a congenital melanocytic nevus. The real importance of NCHs is that, although few cases have been reported in the literature, some cases have shown development of melanoma. Moreover, the only previously reported case of a similar "proliferative neurocristic nodule" analyzed with comparative genomic hybridization showed an aberration pattern similar to melanoma. We present a rare case of NCH associated with a congenital nevus in a 7-year-old boy, with classical histological and immunohistochemical features suggesting a "proliferative neurocristic hamartoma". Comparative genomic hybridization assay showed that chromosomal aberrations were absent in the congenital nevus, whereas, interestingly, the proliferative neurocristic proliferation had an aberration pattern similar to proliferative nodules with gains or losses of entire chromosomes only, similar to typical proliferative nodules and supporting the benign behavior of this lesion. Correspondence: Maria Concepcion Garrido, MD, PhD, Dpto. de Anatomía Patológica, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n, 28041 Madrid, Spain (e-mail: mariagarridoruiz@gmail.com). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

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Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Other: eABR Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

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Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Other: eABR Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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Audiological Benefit and Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Contact Mini

Condition:   Conductive Hearing Loss Interventions:   Device: Adhear;   Device: Contact Mini (CM) Sponsor:   Dominik Riss Recruiting (Source: ClinicalTrials.gov)

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Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

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N.I.S of AIT in Adult Patients With House Dust Mite Allergy in Real Practice in France

Conditions:   Allergic Rhinitis Due to House Dust Mite;   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus Intervention:   Drug: Tablet, Dispersible Sponsors:   ALK-Abelló A/S;   ITEC Services Recruiting (Source: ClinicalTrials.gov)

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BPF Genetics of ILD Study

Conditions:   Lung; Disease, Interstitial, With Fibrosis;   Alveolitis, Extrinsic Allergic;   Bird Fancier's Lung;   Idiopathic Interstitial Pneumonias;   Lung Diseases, Interstitial;   Idiopathic Pulmonary Fibrosis Intervention:   Diagnostic Test: Genetic profiling Sponsors:   NHS Forth Valley;   University of Leicester;   University of Glasgow;   Newcastle University;   British Lung Foundation;   British Pigeon Fanciers Medical Research Not yet recruiting (Source: ClinicalTrials.gov)

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Pay-it-forward RCT for Gonorrhea and Chlamydia Testing

Conditions:   Gonorrhea Male;   Chlamydia;M Interventions:   Other: Pay-it-forward testing;   Other: Pay as you want Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute on Aging (NIA) Recruiting (Source: ClinicalTrials.gov)

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Audiological Benefit and Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Contact Mini

Condition:   Conductive Hearing Loss Interventions:   Device: Adhear;   Device: Contact Mini (CM) Sponsor:   Dominik Riss Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Fwwe43

Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qWbSHl

Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Other: eABR Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FyR2YG

Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Other: eABR Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qZ3RRG

Audiological Benefit and Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Contact Mini

Condition:   Conductive Hearing Loss Interventions:   Device: Adhear;   Device: Contact Mini (CM) Sponsor:   Dominik Riss Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Fww0dd

Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qVE6Si

N.I.S of AIT in Adult Patients With House Dust Mite Allergy in Real Practice in France

Conditions:   Allergic Rhinitis Due to House Dust Mite;   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus Intervention:   Drug: Tablet, Dispersible Sponsors:   ALK-Abelló A/S;   ITEC Services Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FwvSuf

BPF Genetics of ILD Study

Conditions:   Lung; Disease, Interstitial, With Fibrosis;   Alveolitis, Extrinsic Allergic;   Bird Fancier's Lung;   Idiopathic Interstitial Pneumonias;   Lung Diseases, Interstitial;   Idiopathic Pulmonary Fibrosis Intervention:   Diagnostic Test: Genetic profiling Sponsors:   NHS Forth Valley;   University of Leicester;   University of Glasgow;   Newcastle University;   British Lung Foundation;   British Pigeon Fanciers Medical Research Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qZgZGM

Pay-it-forward RCT for Gonorrhea and Chlamydia Testing

Conditions:   Gonorrhea Male;   Chlamydia;M Interventions:   Other: Pay-it-forward testing;   Other: Pay as you want Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute on Aging (NIA) Recruiting (Source: ClinicalTrials.gov)

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1.2 Million Children and Teens Have Peanut Allergies

(MedPage Today) -- Two studies estimate current PA prevalence to be 2.2% (Source: MedPage Today Allergy)

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EpiPens Still Work After Freezing

(MedPage Today) -- Devices still fired after being frozen for 24 hours in study (Source: MedPage Today Allergy)

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Study: Adult-Onset Food Allergy Fairly Common

(MedPage Today) -- Almost half of over 40,000 U.S. adults reported allergy development after age 18 (Source: MedPage Today Allergy)

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1.2 Million Children and Teens Have Peanut Allergies

(MedPage Today) -- Two studies estimate current PA prevalence to be 2.2% (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TvzCPq

EpiPens Still Work After Freezing

(MedPage Today) -- Devices still fired after being frozen for 24 hours in study (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TuHJfd

Study: Adult-Onset Food Allergy Fairly Common

(MedPage Today) -- Almost half of over 40,000 U.S. adults reported allergy development after age 18 (Source: MedPage Today Allergy)

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Deep neck infection in patients with and without human immunodeficiency virus: a comparison of clinical features, complications, and outcomes

We retrospectively studied the clinical features, complications, and outcomes of deep neck infections in 31 adult patients with the human immunodeficiency virus (HIV) (HIV group) and 192 patients without (non-HIV group). In the HIV group, the cause was more likely to be odontogenic (21 (68%) compared with 90 (47%); odds ratio (OR) 2.38; 95% CI 1.06 to 5.32). In both groups, the parapharyngeal, submandibular, and masticator spaces, were those most often involved. However, in the HIV group, Ludwig 's angina was common, and was the main cause of airway obstruction. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Mitchell –Hoole–Kanatas (MHK) questionnaire: the first to measure patient-reported outcomes relating to problems with intimacy after diagnosis and treatment of head and neck cancer

Patient-reported outcomes are increasingly used by clinical teams as indicators of quality when assessing treatment after a diagnosis of head and neck cancer. About a third of patients report reduced sexual interest or enjoyment after such treatment but, despite that, there is no questionnaire about intimacy that has been developed specifically for them. The aim of this study was to develop such a questionnaire, to gain an indication of the relative incidence of individual items, and to compare characteristics such as age, stage, treatment, time since treatment for an established head and neck cancer, and a health-related quality of life (QoL) measure (European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-C30 with the Head and Neck 35 module). (So...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BoUMrw

Deep neck infection in patients with and without human immunodeficiency virus: a comparison of clinical features, complications, and outcomes

We retrospectively studied the clinical features, complications, and outcomes of deep neck infections in 31 adult patients with the human immunodeficiency virus (HIV) (HIV group) and 192 patients without (non-HIV group). In the HIV group, the cause was more likely to be odontogenic (21 (68%) compared with 90 (47%); odds ratio (OR) 2.38; 95% CI 1.06 to 5.32). In both groups, the parapharyngeal, submandibular, and masticator spaces, were those most often involved. However, in the HIV group, Ludwig 's angina was common, and was the main cause of airway obstruction. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Kowr7W

Mitchell –Hoole–Kanatas (MHK) questionnaire: the first to measure patient-reported outcomes relating to problems with intimacy after diagnosis and treatment of head and neck cancer

Patient-reported outcomes are increasingly used by clinical teams as indicators of quality when assessing treatment after a diagnosis of head and neck cancer. About a third of patients report reduced sexual interest or enjoyment after such treatment but, despite that, there is no questionnaire about intimacy that has been developed specifically for them. The aim of this study was to develop such a questionnaire, to gain an indication of the relative incidence of individual items, and to compare characteristics such as age, stage, treatment, time since treatment for an established head and neck cancer, and a health-related quality of life (QoL) measure (European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-C30 with the Head and Neck 35 module). (So...

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Clinical Thyroidology®for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Thyroid hormones have major effects on the heart and palpitations and irregular heart rhythms are frequent symptoms caused by hyperthyroidism. Because of this, hyperthyroidism is associated with increased cardiac problems. Read More…

We welcome your feedback and suggestions. Let us know what you want to see in this publication.

Feedback & Suggestions

The post Clinical Thyroidology^®for the Public – Highlighted Article appeared first on American Thyroid Association.

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Clinical Thyroidology®for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Thyroid hormones have major effects on the heart and palpitations and irregular heart rhythms are frequent symptoms caused by hyperthyroidism. Because of this, hyperthyroidism is associated with increased cardiac problems. Read More…

We welcome your feedback and suggestions. Let us know what you want to see in this publication.

Feedback & Suggestions

The post Clinical Thyroidology^®for the Public – Highlighted Article appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PGZfic

New experimental drug offers hope for those with peanut allergies

An immunotherapy drug may allow allergy sufferers lead more normal lives. (Source: ABC News: Health)

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EpiPens Still Work After Freezing

(MedPage Today) -- Devices still fired after being frozen for 24 hours in study (Source: MedPage Today Allergy)

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Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial

ConclusionPeriodontal treatment with SRP  + aPDT in multiples episodes was not able to promote additional clinical, immunological, and microbiological benefits in smokers when compared SRP alone in patients with chronic periodontitis.Clinical relevanceMultiple episodes of aPDT adjunctive to non-surgical treatment did not improve significantly the clinical, immunological, and microbiological parameters when compared with SRP alone. More randomized clinical trials are needed to evaluate adjuvant therapies for scaling and root planning in smokers with chronic periodontitis.ClinicalTrials.gov Identifier: NCT03039244 (Source: Dental Technology Blog)

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AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial

AstraZeneca said on Friday its immunotherapy drug Imfinzi did not meet the main goal of improving survival rates for patients with the most advanced form of lung cancer, putting pressure on its shares.Reuters Health Information (Source: Medscape Allergy Headlines)

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1.2 Million Children and Teens Have Peanut Allergies

(MedPage Today) -- Two studies estimate current PA prevalence to be 2.2% (Source: MedPage Today Allergy)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TvzCPq

New experimental drug offers hope for those with peanut allergies

An immunotherapy drug may allow allergy sufferers lead more normal lives. (Source: ABC News: Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A9TDSY

EpiPens Still Work After Freezing

(MedPage Today) -- Devices still fired after being frozen for 24 hours in study (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TuHJfd

Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial

ConclusionPeriodontal treatment with SRP  + aPDT in multiples episodes was not able to promote additional clinical, immunological, and microbiological benefits in smokers when compared SRP alone in patients with chronic periodontitis.Clinical relevanceMultiple episodes of aPDT adjunctive to non-surgical treatment did not improve significantly the clinical, immunological, and microbiological parameters when compared with SRP alone. More randomized clinical trials are needed to evaluate adjuvant therapies for scaling and root planning in smokers with chronic periodontitis.ClinicalTrials.gov Identifier: NCT03039244 (Source: Dental Technology Blog)

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AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial

AstraZeneca said on Friday its immunotherapy drug Imfinzi did not meet the main goal of improving survival rates for patients with the most advanced form of lung cancer, putting pressure on its shares.Reuters Health Information (Source: Medscape Allergy Headlines)

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Prevalence of allergic and nonallergic rhinitis in a rural area of northern China based on sensitization to specific aeroallergens

Abstract

Background

Most epidemiologic studies reporting prevalence of allergic rhinitis (AR) and nonallergic rhinitis (NAR) have assessed solely self-reported prevalence, without confirmation by objective measures. Furthermore, reports of prevalence of NAR in Chinese subjects are scarce. Thus, we aimed to explore the prevalence and risk factors of AR and NAR in a Chinese, based on both clinical manifestation and allergic status.

Methods

We conducted a population-based cross-sectional survey, involving 1084 local residents from a rural area of Beijing, China. Participants were enrolled using a stratified two-stage cluster sampling method. All adult participants or the guardians of children completed standardized questionnaires to provide relevant demographic and clinical information. Skin prick tests were also performed to determine sensitization to specific aeroallergens. AR/NAR was classified according to Allergic Rhinitis and its Impact on Asthma criteria.

Results

Prevalence of self-reported AR was 46.80%. Based on SPT results, the confirmed standardized prevalence of AR and NAR were 16.78% and 24.60%, respectively. Severity scores for nasal itching, sneezing, rhinorrhea and congestion were significantly higher in subjects with AR, than subjects with NAR (P < 0.05 for all). The three most common aeroallergens in self-reported AR group were Blattella germanica (16.6%), Dermatophagoides farinae (14.6%), and Dermatophagoides pteronyssinus (13.9%). Family history of AR and atopic dermatitis were significantly associated with AR (adjusted OR: 4.97 and 2.69, respectively), whereas family history of AR and asthma were significantly associated with NAR (adjusted OR: 3.53 and 2.45, respectively). Similarly, comorbid asthma, CRS, and atopic dermatitis were significant risk factors for both AR and NAR.

Conclusions

Combination of standardized questionnaires and specific allergen tests may provide more accurate estimates of prevalence of AR and NAR and associated risk factors.

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1.2 Million Children and Teens Have Peanut Allergies

(MedPage Today) -- Two studies estimate current PA prevalence to be 2.2% (Source: MedPage Today Allergy)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TvzCPq

New experimental drug offers hope for those with peanut allergies

An immunotherapy drug may allow allergy sufferers lead more normal lives. (Source: ABC News: Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A9TDSY

EpiPens Still Work After Freezing

(MedPage Today) -- Devices still fired after being frozen for 24 hours in study (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TuHJfd

Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial

ConclusionPeriodontal treatment with SRP  + aPDT in multiples episodes was not able to promote additional clinical, immunological, and microbiological benefits in smokers when compared SRP alone in patients with chronic periodontitis.Clinical relevanceMultiple episodes of aPDT adjunctive to non-surgical treatment did not improve significantly the clinical, immunological, and microbiological parameters when compared with SRP alone. More randomized clinical trials are needed to evaluate adjuvant therapies for scaling and root planning in smokers with chronic periodontitis.ClinicalTrials.gov Identifier: NCT03039244 (Source: Dental Technology Blog)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ae5FKS

AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial

AstraZeneca said on Friday its immunotherapy drug Imfinzi did not meet the main goal of improving survival rates for patients with the most advanced form of lung cancer, putting pressure on its shares.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zlKhnw

1.2 Million Children and Teens Have Peanut Allergies

(MedPage Today) -- Two studies estimate current PA prevalence to be 2.2% (Source: MedPage Today Allergy)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TvzCPq

New experimental drug offers hope for those with peanut allergies

An immunotherapy drug may allow allergy sufferers lead more normal lives. (Source: ABC News: Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A9TDSY

EpiPens Still Work After Freezing

(MedPage Today) -- Devices still fired after being frozen for 24 hours in study (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TuHJfd

Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial

ConclusionPeriodontal treatment with SRP  + aPDT in multiples episodes was not able to promote additional clinical, immunological, and microbiological benefits in smokers when compared SRP alone in patients with chronic periodontitis.Clinical relevanceMultiple episodes of aPDT adjunctive to non-surgical treatment did not improve significantly the clinical, immunological, and microbiological parameters when compared with SRP alone. More randomized clinical trials are needed to evaluate adjuvant therapies for scaling and root planning in smokers with chronic periodontitis.ClinicalTrials.gov Identifier: NCT03039244 (Source: Dental Technology Blog)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ae5FKS

AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial

AstraZeneca said on Friday its immunotherapy drug Imfinzi did not meet the main goal of improving survival rates for patients with the most advanced form of lung cancer, putting pressure on its shares.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zlKhnw

Prevalence of allergic and nonallergic rhinitis in a rural area of northern China based on sensitization to specific aeroallergens

Abstract

Background

Most epidemiologic studies reporting prevalence of allergic rhinitis (AR) and nonallergic rhinitis (NAR) have assessed solely self-reported prevalence, without confirmation by objective measures. Furthermore, reports of prevalence of NAR in Chinese subjects are scarce. Thus, we aimed to explore the prevalence and risk factors of AR and NAR in a Chinese, based on both clinical manifestation and allergic status.

Methods

We conducted a population-based cross-sectional survey, involving 1084 local residents from a rural area of Beijing, China. Participants were enrolled using a stratified two-stage cluster sampling method. All adult participants or the guardians of children completed standardized questionnaires to provide relevant demographic and clinical information. Skin prick tests were also performed to determine sensitization to specific aeroallergens. AR/NAR was classified according to Allergic Rhinitis and its Impact on Asthma criteria.

Results

Prevalence of self-reported AR was 46.80%. Based on SPT results, the confirmed standardized prevalence of AR and NAR were 16.78% and 24.60%, respectively. Severity scores for nasal itching, sneezing, rhinorrhea and congestion were significantly higher in subjects with AR, than subjects with NAR (P < 0.05 for all). The three most common aeroallergens in self-reported AR group were Blattella germanica (16.6%), Dermatophagoides farinae (14.6%), and Dermatophagoides pteronyssinus (13.9%). Family history of AR and atopic dermatitis were significantly associated with AR (adjusted OR: 4.97 and 2.69, respectively), whereas family history of AR and asthma were significantly associated with NAR (adjusted OR: 3.53 and 2.45, respectively). Similarly, comorbid asthma, CRS, and atopic dermatitis were significant risk factors for both AR and NAR.

Conclusions

Combination of standardized questionnaires and specific allergen tests may provide more accurate estimates of prevalence of AR and NAR and associated risk factors.

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Chronic Rhinosinusitis in Elderly Patients is Associated with an Exaggerated Neutrophilic Pro-Inflammatory Response to Pathogenic Bacteria

The immune signature in elderly patients with CRS suggests a distinct pathophysiology marked by prevalence of bacterial colonization and an exaggerated but apparently ineffective neutrophilic pro-inflammatory response to microbial pathogens. (Source: Journal of Allergy and Clinical Immunology)

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Inter-laboratory variability in multiplexed pneumococcal antibody testing

This pragmatic, updated assessment of variability among pneumococcal antibody assays suggests that variability may now be greater than previously reported, and potentially influential in clinical decision making. (Source: Journal of Allergy and Clinical Immunology)

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Mast cells as protectors of health

Mast cells (MC), well known for their effector functions in Th2 skewed allergic and also autoimmune inflammation, become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs like skin or gut. MC can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy. (Source: Journal of Allergy and Clinical Immunology)

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Chronic Rhinosinusitis in Elderly Patients is Associated with an Exaggerated Neutrophilic Pro-Inflammatory Response to Pathogenic Bacteria

The immune signature in elderly patients with CRS suggests a distinct pathophysiology marked by prevalence of bacterial colonization and an exaggerated but apparently ineffective neutrophilic pro-inflammatory response to microbial pathogens. (Source: Journal of Allergy and Clinical Immunology)

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Inter-laboratory variability in multiplexed pneumococcal antibody testing

This pragmatic, updated assessment of variability among pneumococcal antibody assays suggests that variability may now be greater than previously reported, and potentially influential in clinical decision making. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R6sMhC

Mast cells as protectors of health

Mast cells (MC), well known for their effector functions in Th2 skewed allergic and also autoimmune inflammation, become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs like skin or gut. MC can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy. (Source: Journal of Allergy and Clinical Immunology)

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AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial

AstraZeneca said on Friday its immunotherapy drug Imfinzi did not meet the main goal of improving survival rates for patients with the most advanced form of lung cancer, putting pressure on its shares.Reuters Health Information (Source: Medscape Allergy Headlines)

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Prevalence of Asthma, Rhinitis and Respiratory Symptoms Prevalence of Asthma, Rhinitis and Respiratory Symptoms

Which factors may be implicated in the changes in prevalence noted for respiratory disorders and symptoms over a 20-year period?BMC Pulmonary Medicine (Source: Medscape Allergy Headlines)

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AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial AstraZeneca's Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial

AstraZeneca said on Friday its immunotherapy drug Imfinzi did not meet the main goal of improving survival rates for patients with the most advanced form of lung cancer, putting pressure on its shares.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zlKhnw

Prevalence of Asthma, Rhinitis and Respiratory Symptoms Prevalence of Asthma, Rhinitis and Respiratory Symptoms

Which factors may be implicated in the changes in prevalence noted for respiratory disorders and symptoms over a 20-year period?BMC Pulmonary Medicine (Source: Medscape Allergy Headlines)

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Ethnopharmaceutical knowledge in Samogitia region of Lithuania: where old traditions overlap with modern medicine

Modern ethnopharmaceutical studies are still quite unusual in Northern Europe. Data regarding the medicinal use of plants, animals, and fungi and also of spiritual rituals of healing is obtained mostly from et...

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Clinical Thyroidology®for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Thyroid hormones have major effects on the heart and palpitations and irregular heart rhythms are frequent symptoms caused by hyperthyroidism. Because of this, hyperthyroidism is associated with increased cardiac problems. Read More…

We welcome your feedback and suggestions. Let us know what you want to see in this publication.

Feedback & Suggestions

The post Clinical Thyroidology^®for the Public – Highlighted Article appeared first on American Thyroid Association.

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Comparing Indigenous and public health infant feeding recommendations in Peru: opportunities for optimizing intercultural health policies

The problem of childhood undernutrition in low-income countries persists despite long-standing efforts by local governmental and international development agencies. In order to address this problem, the Peruvi...

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Techniques for Remotely Programming Children With Cochlear Implants Using Pediatric Audiological Methods via Telepractice.

Conclusions: The results from studies to date suggest that distance technology can be used successfully to program CI sound processors for young children using standard, age-appropriate testing techniques. The alternative of remote testing has substantial implications for reducing time and travel burdens for families, potentially leading to the construction of appropriate maps for young children with CIs in a timelier manner. PMID: 30452743 [PubMed - in process] (Source: American Journal of Audiology)

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Toward Better Outcomes in Audiology Distance Education: An Educational Data Mining Approach.

Conclusions: EDM methods offer new tools to discover knowledge from digital traces (i.e., logs) and support key stakeholders (students, instructors, or course administrators) to raise awareness about course dynamics. This approach has the potential to foster a better understanding and management of educational processes in audiology distance education. PMID: 30452755 [PubMed - in process] (Source: American Journal of Audiology)

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User-Innovated eHealth Solutions for Service Delivery to Older Persons With Hearing Impairment.

Conclusions: Future eHealth solutions must offer personalized rehabilitation strategies that are appropriate for every person with hearing impairment and their level of technical savviness. Thus, a central requirement is anchoring of digital support in the clients' everyday life situations by facilitating easy access to personalized information, communication, and learning milieus. Moreover, the participants' visions for eHealth solutions call for providing both traditional analogue and digital services. Supplemental Material: https://ift.tt/2r5rTLf. PMID: 30452745 [PubMed - in process] (Source: American Journal of Audiology)

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An Application of the Medical Research Council's Guidelines for Evaluating Complex Interventions: A Usability Study Assessing Smartphone-Connected Listening Devices in Adults With Hearing Loss.

Conclusions: This developmental work, guided by the Medical Research Council's framework, lays the foundation for feasibility and pilot studies, leading to high-quality research assessing the effectiveness of smartphone-connected listening devices. This future evidence is necessary to guide health care commissioners and policymakers when considering new service delivery models for adults living with hearing loss. PMID: 30452751 [PubMed - in process] (Source: American Journal of Audiology)

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Big Data for Sound Policies: Toward Evidence-Informed Hearing Health Policies.

Conclusion: In the future, Big Data can inform all steps of the hearing health policy-making process and all levels of hearing health care services. PMID: 30452753 [PubMed - in process] (Source: American Journal of Audiology)

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Internet and Audiology: A Review of the Third International Meeting.

Conclusion: Innovations in teleaudiology, mHealth, and Internet-based audiology are developing at a rapid pace and thus research in the field must continue. We invite readers to the next International Meeting on Internet and Audiology that will take place in Southampton, England, June 17-18, 2019. PMID: 30452741 [PubMed - in process] (Source: American Journal of Audiology)

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Geographic Distribution of the Hearing Aid Dispensing Workforce: A Teleaudiology Planning Assessment for Arizona.

Conclusions: There are geographic areas of Arizona that lack licensed hearing aid locations yet are populated by individuals who may need services. Resource availability data inform teleaudiology program expansion. Future research will include data from providers and community members on their perceived needs for services. PMID: 30452750 [PubMed - in process] (Source: American Journal of Audiology)

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A Smartphone National Hearing Test: Performance and Characteristics of Users.

Conclusions: High test uptake, particularly among younger users, and high overall referral rate indicates that the hearZA app addresses a public health need. The test also reaches target audiences, including those with self-reported hearing difficulty and those with normal hearing who should monitor their hearing ability. PMID: 30452748 [PubMed - in process] (Source: American Journal of Audiology)

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Empowering Senior Cochlear Implant Users at Home via a Tablet Computer Application.

Conclusions: This study evaluated a tablet computer application (MHA) for experienced senior CI users by means of a prospective design, which provided novel insights into delivering CI care into the home of the CI user. The user feedback from this small-scale study suggests that the participants are open to take more responsibility for and to become a more active actor in their own hearing care, if only this is facilitated with the right tools. This may foster the evolution from a clinic-led to a more patient-centered care model, where CI users feel more empowered in the self-management of their hearing implant device. PMID: 30452746 [PubMed - in process] (Source: American Journal of Audiology)

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Stories From the Webcams: Cincinnati Children's Hospital Medical Center Audiology Telehealth and Pediatric Auditory Device Services.

Conclusion: The described regulatory, technological, and training hierarchy provides a framework for audiologists interested in starting a telehealth program. The cases presented illustrate that telehealth can be used to provide some auditory device services, such as troubleshooting, mapping, and parent consulting. PMID: 30452744 [PubMed - in process] (Source: American Journal of Audiology)

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Long-Term Efficacy of Audiologist-Guided Internet-Based Cognitive Behavior Therapy for Tinnitus.

Conclusions: The clinical benefits of audiologist-guided iCBT for tinnitus and tinnitus-related difficulties were sustained 1 year postintervention. Predictors of outcome indicated that the intervention is applicable to a wide range of participants regardless of their demographic backgrounds. Attempts should be made to minimize unwanted events in subsequent trials. PMID: 30452747 [PubMed - in process] (Source: American Journal of Audiology)

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Toward Better Outcomes in Audiology Distance Education: An Educational Data Mining Approach.

Conclusions: EDM methods offer new tools to discover knowledge from digital traces (i.e., logs) and support key stakeholders (students, instructors, or course administrators) to raise awareness about course dynamics. This approach has the potential to foster a better understanding and management of educational processes in audiology distance education. PMID: 30452755 [PubMed - in process] (Source: American Journal of Audiology)

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User-Innovated eHealth Solutions for Service Delivery to Older Persons With Hearing Impairment.

Conclusions: Future eHealth solutions must offer personalized rehabilitation strategies that are appropriate for every person with hearing impairment and their level of technical savviness. Thus, a central requirement is anchoring of digital support in the clients' everyday life situations by facilitating easy access to personalized information, communication, and learning milieus. Moreover, the participants' visions for eHealth solutions call for providing both traditional analogue and digital services. Supplemental Material: https://ift.tt/2r5rTLf. PMID: 30452745 [PubMed - in process] (Source: American Journal of Audiology)

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Techniques for Remotely Programming Children With Cochlear Implants Using Pediatric Audiological Methods via Telepractice.

Conclusions: The results from studies to date suggest that distance technology can be used successfully to program CI sound processors for young children using standard, age-appropriate testing techniques. The alternative of remote testing has substantial implications for reducing time and travel burdens for families, potentially leading to the construction of appropriate maps for young children with CIs in a timelier manner. PMID: 30452743 [PubMed - in process] (Source: American Journal of Audiology)

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Big Data for Sound Policies: Toward Evidence-Informed Hearing Health Policies.

Conclusion: In the future, Big Data can inform all steps of the hearing health policy-making process and all levels of hearing health care services. PMID: 30452753 [PubMed - in process] (Source: American Journal of Audiology)

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An Application of the Medical Research Council's Guidelines for Evaluating Complex Interventions: A Usability Study Assessing Smartphone-Connected Listening Devices in Adults With Hearing Loss.

Conclusions: This developmental work, guided by the Medical Research Council's framework, lays the foundation for feasibility and pilot studies, leading to high-quality research assessing the effectiveness of smartphone-connected listening devices. This future evidence is necessary to guide health care commissioners and policymakers when considering new service delivery models for adults living with hearing loss. PMID: 30452751 [PubMed - in process] (Source: American Journal of Audiology)

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Findings and Ethical Considerations From a Thematic Analysis of Threads Within Tinnitus Online Support Groups.

Conclusions: This study represents the 1st research into discussion forums in tinnitus online support groups. A nonintrusive (passive) analysis method was used, whereby messages comprising the dataset were retrieved without direct interaction with the discussion forum. Individuals and the community of tinnitus online support groups are deemed to be at low risk from potential harm in this study. Most tinnitus patients likely benefit from accessing online support groups, for example, they discover they are not alone, and they find new coping strategies. However, for those who are particularly vulnerable or prone to psychological stress, accessing these groups could be detrimental. PMID: 30452754 [PubMed - in process] (Source: American Journal of Audiology)

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Automated Characterization of Mobile Health Apps' Features by Extracting Information From the Web: An Exploratory Study.

Conclusions: These preliminary results suggested the viability of automated characterization of apps based on text analytics and highlighted directions for improvement in terms of classification rules and vocabularies, analysis of semantic types, and extraction of key features (promoters, services, and users). The availability of automated tools for app characterization is important as it may support health care professionals in informed, aware selection of health apps to recommend to their patients. PMID: 30452752 [PubMed - in process] (Source: American Journal of Audiology)

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Geographic Distribution of the Hearing Aid Dispensing Workforce: A Teleaudiology Planning Assessment for Arizona.

Conclusions: There are geographic areas of Arizona that lack licensed hearing aid locations yet are populated by individuals who may need services. Resource availability data inform teleaudiology program expansion. Future research will include data from providers and community members on their perceived needs for services. PMID: 30452750 [PubMed - in process] (Source: American Journal of Audiology)

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A Smartphone National Hearing Test: Performance and Characteristics of Users.

Conclusions: High test uptake, particularly among younger users, and high overall referral rate indicates that the hearZA app addresses a public health need. The test also reaches target audiences, including those with self-reported hearing difficulty and those with normal hearing who should monitor their hearing ability. PMID: 30452748 [PubMed - in process] (Source: American Journal of Audiology)

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Empowering Senior Cochlear Implant Users at Home via a Tablet Computer Application.

Conclusions: This study evaluated a tablet computer application (MHA) for experienced senior CI users by means of a prospective design, which provided novel insights into delivering CI care into the home of the CI user. The user feedback from this small-scale study suggests that the participants are open to take more responsibility for and to become a more active actor in their own hearing care, if only this is facilitated with the right tools. This may foster the evolution from a clinic-led to a more patient-centered care model, where CI users feel more empowered in the self-management of their hearing implant device. PMID: 30452746 [PubMed - in process] (Source: American Journal of Audiology)

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Stories From the Webcams: Cincinnati Children's Hospital Medical Center Audiology Telehealth and Pediatric Auditory Device Services.

Conclusion: The described regulatory, technological, and training hierarchy provides a framework for audiologists interested in starting a telehealth program. The cases presented illustrate that telehealth can be used to provide some auditory device services, such as troubleshooting, mapping, and parent consulting. PMID: 30452744 [PubMed - in process] (Source: American Journal of Audiology)

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Newborn Screening for Severe Combined Immunodeficiency in the United States

In the United States, significant improvement in diagnosis and outcomes for children affected with severe combined immunodeficiency has followed institution of newborn screening using an assay to measure T-cell receptor excision circles in newborn dried blood spot specimens. Key to this outcome is the avoidance of infectious complications in infants with severe combined immunodeficiency. (Source: Immunology and Allergy Clinics of North America)

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Update on Advances in Hematopoietic Cell Transplantation for Primary Immunodeficiency Disorders

Hematopoietic stem cell transplantation (HSCT) in patients with primary immunodeficiency disorders (PIDDs) is being increasingly used as a curative option. Understanding the critical components, such as disease 's nature and activity and pre-HSCT and post-HSCT patient care is key to a successful outcome. HSCT should be tailored to the underlying PIDD, as different PIDDs, such as severe combined immune deficiency, Treg dysfunction, and phagocytic disorders, have different transplant approaches. Therefore, successful HSCT in patients with PIDDs requires teamwork between immunologists and transplant physicians. In this article, the authors elaborate on various aspects of PIDD-HSCT and highlight recent advances. (Source: Immunology and Allergy Clinics of North America)

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Hereditary Autoinflammatory Disorders

This article focuses on the clinical presentation of IL-1 and interferon-driven autoinflammatory disorders, and discusses novel diseases with features of immunodeficiency. Approaches to the clinical diagnosis, genetic testing, and treatment of these disorders are addressed. (Source: Immunology and Allergy Clinics of North America)

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Primary Immunodeficiency Disorders

This issue on primary immunodeficiency disorders (PIDD) builds upon a previous set of reviews in the Immunology and Allergy Clinics of North America. The field of Clinical Immunology continues to expand at a rapid rate, so this issue updates readers on new diagnoses and new therapies and highlights some of the exciting developments in our field. Many of our well-known colleagues have contributed their expertise and time to educate us about important advances, which will benefit our patients with PIDD. (Source: Immunology and Allergy Clinics of North America)

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Newborn Screening for Severe Combined Immunodeficiency in the United States

In the United States, significant improvement in diagnosis and outcomes for children affected with severe combined immunodeficiency has followed institution of newborn screening using an assay to measure T-cell receptor excision circles in newborn dried blood spot specimens. Key to this outcome is the avoidance of infectious complications in infants with severe combined immunodeficiency. (Source: Immunology and Allergy Clinics of North America)

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Update on Advances in Hematopoietic Cell Transplantation for Primary Immunodeficiency Disorders

Hematopoietic stem cell transplantation (HSCT) in patients with primary immunodeficiency disorders (PIDDs) is being increasingly used as a curative option. Understanding the critical components, such as disease 's nature and activity and pre-HSCT and post-HSCT patient care is key to a successful outcome. HSCT should be tailored to the underlying PIDD, as different PIDDs, such as severe combined immune deficiency, Treg dysfunction, and phagocytic disorders, have different transplant approaches. Therefore, successful HSCT in patients with PIDDs requires teamwork between immunologists and transplant physicians. In this article, the authors elaborate on various aspects of PIDD-HSCT and highlight recent advances. (Source: Immunology and Allergy Clinics of North America)

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Hereditary Autoinflammatory Disorders

This article focuses on the clinical presentation of IL-1 and interferon-driven autoinflammatory disorders, and discusses novel diseases with features of immunodeficiency. Approaches to the clinical diagnosis, genetic testing, and treatment of these disorders are addressed. (Source: Immunology and Allergy Clinics of North America)

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Primary Immunodeficiency Disorders

This issue on primary immunodeficiency disorders (PIDD) builds upon a previous set of reviews in the Immunology and Allergy Clinics of North America. The field of Clinical Immunology continues to expand at a rapid rate, so this issue updates readers on new diagnoses and new therapies and highlights some of the exciting developments in our field. Many of our well-known colleagues have contributed their expertise and time to educate us about important advances, which will benefit our patients with PIDD. (Source: Immunology and Allergy Clinics of North America)

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Double Fogarty balloon catheter technique for difficult to retrieve esophageal foreign bodies

Foreign body ingestion is common, especially in the pediatric population. Plans for retrieval should be tailored to the specific esophageal foreign bodies.

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Effectiveness of discovery learning using a mobile otoscopy simulator on knowledge acquisition and retention in medical students: a randomized controlled trial

Portable educational technologies, like simulators, afford students the opportunity to learn independently. A key question in education, is how to pair self-regulated learning (SRL) with direct instruction. A ...

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Long term follow-up demonstrating stability and patient satisfaction of minimally invasive punch technique for percutaneous bone anchored hearing devices

Minimally Invasive Ponto Surgery (MIPS) was recently described to facilitate the placement of percutaneous bone anchored hearing devices. As early adopters of this new procedure, we sought to perform a quality...

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Effectiveness of discovery learning using a mobile otoscopy simulator on knowledge acquisition and retention in medical students: a randomized controlled trial

Portable educational technologies, like simulators, afford students the opportunity to learn independently. A key question in education, is how to pair self-regulated learning (SRL) with direct instruction. A ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUZnoV

Long term follow-up demonstrating stability and patient satisfaction of minimally invasive punch technique for percutaneous bone anchored hearing devices

Minimally Invasive Ponto Surgery (MIPS) was recently described to facilitate the placement of percutaneous bone anchored hearing devices. As early adopters of this new procedure, we sought to perform a quality...

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Cardiac metastasis in a living patient with oral cancer

Cardiac metastasis from head and neck cancers are very rare. Metastases to heart are mostly diagnosed at autopsy, and seldom found while patients are alive. Patients with cardiac metastasis do not present with specific symptoms in the early stages, and diagnosis is often delayed until the disease has advanced significantly. Here, we report a 66-year-old lady who was diagnosed with cardiac metastasis 10 months after surgical resection of oral cancer. She died one month following the discovery of cardiac metastasis.

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Surgical deroofing in the treatment of patients with auricular pseudocyst

An auricular pseudocyst is a fluid filled cavity, characterized by a lack of epithelium, in the intra-cartilaginous space. Clinically, it presents as a painless lump on the upper anterior surface of the ear. Various treatment methods have been discussed in the literature, including aspiration, incision and drainage, or steroid injection. However, these approaches are associated with a high rate of recurrence and results are often esthetically unsatisfactory; therefore, a need for improved treatment approaches remains.

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Abramson Developing CAR T-Cell Therapy for Mesothelioma

The National Cancer Institute awarded a five-year, $10.7 million grant to the Abramson Cancer Center at the University of Pennsylvania to develop CAR T-cell therapy for mesothelioma and lung cancer. The hopes are high for a breakthrough. The program involves a laboratory modification of a patient's T cells — a type of white blood cell — that prompts the immune system to attack cancer cells. The therapy also is known as chimeric antigen receptor T-cell therapy. It already is revolutionizing the way some blood and bone marrow cancers are treated. The grant is designed to investigate whether this type of gene therapy can do the same for solid tumors such as mesothelioma. "CAR T cells have completely changed the way we treat leukemia, so the hope is that yes, over the next decade we ca...

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Eyes of CJD patients show evidence of prions

(NIH/National Institute of Allergy and Infectious Diseases) NIH scientists and colleagues have found evidence of the infectious agent of sporadic Creutzfeldt-Jakob disease (CJD) in the eyes of deceased CJD patients. The finding suggests that the eye may be a source for early CJD diagnosis and raises questions about the safety of routine eye exams and corneal transplants. Sporadic CJD, a fatal neurodegenerative prion disease of humans, is untreatable and difficult to diagnose. (Source: EurekAlert! - Medicine and Health)

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Abramson Developing CAR T-Cell Therapy for Mesothelioma

The National Cancer Institute awarded a five-year, $10.7 million grant to the Abramson Cancer Center at the University of Pennsylvania to develop CAR T-cell therapy for mesothelioma and lung cancer. The hopes are high for a breakthrough. The program involves a laboratory modification of a patient's T cells — a type of white blood cell — that prompts the immune system to attack cancer cells. The therapy also is known as chimeric antigen receptor T-cell therapy. It already is revolutionizing the way some blood and bone marrow cancers are treated. The grant is designed to investigate whether this type of gene therapy can do the same for solid tumors such as mesothelioma. "CAR T cells have completely changed the way we treat leukemia, so the hope is that yes, over the next decade we ca...

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Regulating the immune system's 'regulator'

(Institute for Basic Science) A research team at the Academy of Immunology and Microbiology, within the Institute for Basic Science (IBS) has discovered a possible therapeutic target that pulls the reins of immunity. On Nature Communications, the scientists reported that mice lacking Foxp1 protein in some specific immune cells are more susceptible to immune-induced inflammation. (Source: EurekAlert! - Biology)

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Eyes of CJD patients show evidence of prions

(NIH/National Institute of Allergy and Infectious Diseases) NIH scientists and colleagues have found evidence of the infectious agent of sporadic Creutzfeldt-Jakob disease (CJD) in the eyes of deceased CJD patients. The finding suggests that the eye may be a source for early CJD diagnosis and raises questions about the safety of routine eye exams and corneal transplants. Sporadic CJD, a fatal neurodegenerative prion disease of humans, is untreatable and difficult to diagnose. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Fzvg7c

Abramson Developing CAR T-Cell Therapy for Mesothelioma

The National Cancer Institute awarded a five-year, $10.7 million grant to the Abramson Cancer Center at the University of Pennsylvania to develop CAR T-cell therapy for mesothelioma and lung cancer. The hopes are high for a breakthrough. The program involves a laboratory modification of a patient's T cells — a type of white blood cell — that prompts the immune system to attack cancer cells. The therapy also is known as chimeric antigen receptor T-cell therapy. It already is revolutionizing the way some blood and bone marrow cancers are treated. The grant is designed to investigate whether this type of gene therapy can do the same for solid tumors such as mesothelioma. "CAR T cells have completely changed the way we treat leukemia, so the hope is that yes, over the next decade we ca...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FzPxcA

Regulating the immune system's 'regulator'

(Institute for Basic Science) A research team at the Academy of Immunology and Microbiology, within the Institute for Basic Science (IBS) has discovered a possible therapeutic target that pulls the reins of immunity. On Nature Communications, the scientists reported that mice lacking Foxp1 protein in some specific immune cells are more susceptible to immune-induced inflammation. (Source: EurekAlert! - Biology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2r5jOWV

Eyes of CJD patients show evidence of prions

(NIH/National Institute of Allergy and Infectious Diseases) NIH scientists and colleagues have found evidence of the infectious agent of sporadic Creutzfeldt-Jakob disease (CJD) in the eyes of deceased CJD patients. The finding suggests that the eye may be a source for early CJD diagnosis and raises questions about the safety of routine eye exams and corneal transplants. Sporadic CJD, a fatal neurodegenerative prion disease of humans, is untreatable and difficult to diagnose. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Fzvg7c

Abramson Developing CAR T-Cell Therapy for Mesothelioma

The National Cancer Institute awarded a five-year, $10.7 million grant to the Abramson Cancer Center at the University of Pennsylvania to develop CAR T-cell therapy for mesothelioma and lung cancer. The hopes are high for a breakthrough. The program involves a laboratory modification of a patient's T cells — a type of white blood cell — that prompts the immune system to attack cancer cells. The therapy also is known as chimeric antigen receptor T-cell therapy. It already is revolutionizing the way some blood and bone marrow cancers are treated. The grant is designed to investigate whether this type of gene therapy can do the same for solid tumors such as mesothelioma. "CAR T cells have completely changed the way we treat leukemia, so the hope is that yes, over the next decade we ca...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FzPxcA

Regulating the immune system's 'regulator'

(Institute for Basic Science) A research team at the Academy of Immunology and Microbiology, within the Institute for Basic Science (IBS) has discovered a possible therapeutic target that pulls the reins of immunity. On Nature Communications, the scientists reported that mice lacking Foxp1 protein in some specific immune cells are more susceptible to immune-induced inflammation. (Source: EurekAlert! - Biology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2r5jOWV

Eyes of CJD patients show evidence of prions

(NIH/National Institute of Allergy and Infectious Diseases) NIH scientists and colleagues have found evidence of the infectious agent of sporadic Creutzfeldt-Jakob disease (CJD) in the eyes of deceased CJD patients. The finding suggests that the eye may be a source for early CJD diagnosis and raises questions about the safety of routine eye exams and corneal transplants. Sporadic CJD, a fatal neurodegenerative prion disease of humans, is untreatable and difficult to diagnose. (Source: EurekAlert! - Medicine and Health)

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Translation and validation of the Arabic version of the 5-item Oral health impact profile: OHIP5-Ar

The aim of this study was to translate and validate an Arabic version of the 5-item Oral Health Impact Profile (OHIP).

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Clinical validity and diagnostic accuracy of the Maslach Burnout Inventory-Student Survey in Sri Lanka

Absence of context-specific clinically validated cut-off values for assessing burnout as a dichotomous phenomenon has hindered the progress of student burnout research with regard to quantifying the magnitude ...

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The quality of life when a partner has substance use problems: a scoping review

To examine the existing body of knowledge on quality of life (QoL) in partners of people with substance use problems (PP-SUPs) to provide a synthesized summary of the evidence and identify gaps in our knowledg...

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Comparing oral health in patients with different levels of dental anxiety

Dental Anxiety is still today one of the most common fears and is therefore a great challenge for every dental practitioner. The aim of this study was to identify patients with dental anxiety using the Dental ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zk7LJH

Translation and validation of the Arabic version of the 5-item Oral health impact profile: OHIP5-Ar

The aim of this study was to translate and validate an Arabic version of the 5-item Oral Health Impact Profile (OHIP).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Kq9fGI

Clinical validity and diagnostic accuracy of the Maslach Burnout Inventory-Student Survey in Sri Lanka

Absence of context-specific clinically validated cut-off values for assessing burnout as a dichotomous phenomenon has hindered the progress of student burnout research with regard to quantifying the magnitude ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Bothyx

The quality of life when a partner has substance use problems: a scoping review

To examine the existing body of knowledge on quality of life (QoL) in partners of people with substance use problems (PP-SUPs) to provide a synthesized summary of the evidence and identify gaps in our knowledg...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KlD4bd

Comparing oral health in patients with different levels of dental anxiety

Dental Anxiety is still today one of the most common fears and is therefore a great challenge for every dental practitioner. The aim of this study was to identify patients with dental anxiety using the Dental ...

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High-Resolution Chest Computed Tomography Imaging of the Lungs: Impact of 1024 Matrix Reconstruction and Photon-Counting Detector Computed Tomography

Objectives The aim of this study was to evaluate if a high-resolution photon-counting detector computed tomography (PCD-CT) system with a 1024×1024 matrix reconstruction can improve the visualization of fine structures in the lungs compared with conventional high-resolution CT (HRCT). Materials and Methods Twenty-two adult patients referred for clinical chest HRCT (mean CTDI vol, 13.58 mGy) underwent additional dose-matched PCD-CT (mean volume CT dose index, 13.37 mGy) after written informed consent. Computed tomography images were reconstructed at a slice thickness of 1.5 mm and an image increment of 1 mm with our routine HRCT reconstruction kernels (B46 and Bv49) at 512 and 1024 matrix sizes for conventional energy-integrating detector (EID) CT scans. For PCD-CT, routine B46 kernel and an additional sharp kernel (Q65, unavailable for EID) images were reconstructed at 1024 matrix size. Two thoracic radiologists compared images from EID and PCD-CT noting the highest level bronchus clearly identified in each lobe of the right lung, and rating bronchial wall conspicuity of third- and fourth-order bronchi. Lung nodules were also compared with the B46/EID/512 images using a 5-point Likert scale. Statistical analysis was performed using a Wilcoxon signed rank test with a P

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High-Resolution Chest Computed Tomography Imaging of the Lungs: Impact of 1024 Matrix Reconstruction and Photon-Counting Detector Computed Tomography

Objectives The aim of this study was to evaluate if a high-resolution photon-counting detector computed tomography (PCD-CT) system with a 1024×1024 matrix reconstruction can improve the visualization of fine structures in the lungs compared with conventional high-resolution CT (HRCT). Materials and Methods Twenty-two adult patients referred for clinical chest HRCT (mean CTDI vol, 13.58 mGy) underwent additional dose-matched PCD-CT (mean volume CT dose index, 13.37 mGy) after written informed consent. Computed tomography images were reconstructed at a slice thickness of 1.5 mm and an image increment of 1 mm with our routine HRCT reconstruction kernels (B46 and Bv49) at 512 and 1024 matrix sizes for conventional energy-integrating detector (EID) CT scans. For PCD-CT, routine B46 kernel and an additional sharp kernel (Q65, unavailable for EID) images were reconstructed at 1024 matrix size. Two thoracic radiologists compared images from EID and PCD-CT noting the highest level bronchus clearly identified in each lobe of the right lung, and rating bronchial wall conspicuity of third- and fourth-order bronchi. Lung nodules were also compared with the B46/EID/512 images using a 5-point Likert scale. Statistical analysis was performed using a Wilcoxon signed rank test with a P

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Inter-laboratory variability in multiplexed pneumococcal antibody testing

This pragmatic, updated assessment of variability among pneumococcal antibody assays suggests that variability may now be greater than previously reported, and potentially influential in clinical decision making.

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Chronic Rhinosinusitis in Elderly Patients is Associated with an Exaggerated Neutrophilic Pro-Inflammatory Response to Pathogenic Bacteria

The immune signature in elderly patients with CRS suggests a distinct pathophysiology marked by prevalence of bacterial colonization and an exaggerated but apparently ineffective neutrophilic pro-inflammatory response to microbial pathogens.

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Mast cells as protectors of health

Mast cells (MC), well known for their effector functions in Th2 skewed allergic and also autoimmune inflammation, become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs like skin or gut. MC can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FHQ0tc

Inter-laboratory variability in multiplexed pneumococcal antibody testing

This pragmatic, updated assessment of variability among pneumococcal antibody assays suggests that variability may now be greater than previously reported, and potentially influential in clinical decision making.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FHZXHs

Chronic Rhinosinusitis in Elderly Patients is Associated with an Exaggerated Neutrophilic Pro-Inflammatory Response to Pathogenic Bacteria

The immune signature in elderly patients with CRS suggests a distinct pathophysiology marked by prevalence of bacterial colonization and an exaggerated but apparently ineffective neutrophilic pro-inflammatory response to microbial pathogens.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qVl5zz

Mast cells as protectors of health

Mast cells (MC), well known for their effector functions in Th2 skewed allergic and also autoimmune inflammation, become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs like skin or gut. MC can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy.

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Changes of the maxillary width and upper airway spaces in young adults after the surgically assisted rapid palatal expansion with surgically facilitated orthodontic therapy

The objective was to evaluate the changes of the maxillary width and upper airway spaces in young adults after the surgically assisted rapid palatal expansion (SARPE) combined with surgically facilitated orthodontic therapy (SFOT) with the maxillary transverse deficiency.

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Data matters: implications for surgery and anesthesia in achieving universal health coverage

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Potential gender remuneration gaps in anesthesiology

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Contributions of academic institutions in high income countries to anesthesia and surgical care in low- and middle-income countries: are they providing what is really needed?

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Data matters: implications for surgery and anesthesia in achieving universal health coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Tv1kf5

Potential gender remuneration gaps in anesthesiology

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AaSVVg

Contributions of academic institutions in high income countries to anesthesia and surgical care in low- and middle-income countries: are they providing what is really needed?

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Mitchell–Hoole–Kanatas (MHK) questionnaire: the first to measure patient-reported outcomes relating to problems with intimacy after diagnosis and treatment of head and neck cancer

Patient-reported outcomes are increasingly used by clinical teams as indicators of quality when assessing treatment after a diagnosis of head and neck cancer. About a third of patients report reduced sexual interest or enjoyment after such treatment but, despite that, there is no questionnaire about intimacy that has been developed specifically for them. The aim of this study was to develop such a questionnaire, to gain an indication of the relative incidence of individual items, and to compare characteristics such as age, stage, treatment, time since treatment for an established head and neck cancer, and a health-related quality of life (QoL) measure (European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-C30 with the Head and Neck 35 module).

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Deep neck infection in patients with and without human immunodeficiency virus: a comparison of clinical features, complications, and outcomes

We retrospectively studied the clinical features, complications, and outcomes of deep neck infections in 31 adult patients with the human immunodeficiency virus (HIV) (HIV group) and 192 patients without (non-HIV group). In the HIV group, the cause was more likely to be odontogenic (21 (68%) compared with 90 (47%); odds ratio (OR) 2.38; 95% CI 1.06 to 5.32). In both groups, the parapharyngeal, submandibular, and masticator spaces, were those most often involved. However, in the HIV group, Ludwig's angina was common, and was the main cause of airway obstruction.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A8Gae3

Mitchell–Hoole–Kanatas (MHK) questionnaire: the first to measure patient-reported outcomes relating to problems with intimacy after diagnosis and treatment of head and neck cancer

Patient-reported outcomes are increasingly used by clinical teams as indicators of quality when assessing treatment after a diagnosis of head and neck cancer. About a third of patients report reduced sexual interest or enjoyment after such treatment but, despite that, there is no questionnaire about intimacy that has been developed specifically for them. The aim of this study was to develop such a questionnaire, to gain an indication of the relative incidence of individual items, and to compare characteristics such as age, stage, treatment, time since treatment for an established head and neck cancer, and a health-related quality of life (QoL) measure (European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-C30 with the Head and Neck 35 module).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A8GcCH

Deep neck infection in patients with and without human immunodeficiency virus: a comparison of clinical features, complications, and outcomes

We retrospectively studied the clinical features, complications, and outcomes of deep neck infections in 31 adult patients with the human immunodeficiency virus (HIV) (HIV group) and 192 patients without (non-HIV group). In the HIV group, the cause was more likely to be odontogenic (21 (68%) compared with 90 (47%); odds ratio (OR) 2.38; 95% CI 1.06 to 5.32). In both groups, the parapharyngeal, submandibular, and masticator spaces, were those most often involved. However, in the HIV group, Ludwig's angina was common, and was the main cause of airway obstruction.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A8Gae3

First Case of Allergy to Second-Hand Marijuana Reported First Case of Allergy to Second-Hand Marijuana Reported

Allergy to marijuana can occur in adults who use it, but researchers are flagging the first report of a young child with a positive allergy test who was exposed only to second-hand smoke.Medscape Medical News (Source: Medscape Today Headlines)

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Peanut allergy treatment raises concerns over cost

Patients would probably have to keep taking the medication to maintain tolerance levels (Source: FT.com - Drugs and Healthcare)

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Secondhand cannabis smoke may cause allergy, worsen asthma in children

(Reuters Health) - Secondhand marijuana smoke appears to have provoked a cannabis allergy and worsened the asthma of a 6-year-old child, researchers told the American College of Allergy, Asthma, and Immunology's annual conference in Seattle. (Source: Reuters: Health)

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First Case of Allergy to Second-Hand Marijuana Reported First Case of Allergy to Second-Hand Marijuana Reported

Allergy to marijuana can occur in adults who use it, but researchers are flagging the first report of a young child with a positive allergy test who was exposed only to second-hand smoke.Medscape Medical News (Source: Medscape Today Headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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