Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,: 11/17/18

Σάββατο 17 Νοεμβρίου 2018

Pay-it-forward RCT for Gonorrhea and Chlamydia Testing

Conditions: Gonorrhea Male; Chlamydia;M Interventions: Other: Pay-it-forward testing; Other: Pay as you want Sponsors: University of North Carolina, Chapel Hill; National Institute of Allergy and Infectious Diseases (NIAID); National Institute on Aging (NIA) Recruiting (Source: ClinicalTrials.gov)

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Seal, Stopping Atopic Dermatitis and Allergy Study

Conditions: Eczema, Infantile; Eczema; Atopic Dermatitis Eczema; Atopic Dermatitis Interventions: Combination Product: Tri-lipid skin barrier cream (Epiceram); Combination Product: Fluticasone propionate Cream 0.05% Sponsors: Stanford University; King's College London; National Jewish Health Not yet recruiting (Source: ClinicalTrials.gov)

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Evaluating the Safety and Pharmacokinetics of VRC-HIVMAB075-00-AB (VRC07-523LS) in the Sera and Mucosae of Healthy, HIV-Uninfected Adult Participants

Condition: HIV Infections Intervention: Biological: VRC07-523LS Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Pragmatic Assessment Study Influenza Vaccine Effectiveness in DoD

Conditions: Influenza; Influenza-like Illness Interventions: Biological: Egg based influenza vaccines; Biological: Recombinant influenza vaccines; Biological: Cell-culture based influenza vaccines Sponsors: Henry M. Jackson Foundation for the Advancement of Military Medicine; National Institute of Allergy and Infectious Diseases (NIAID); Food and Drug Administration (FDA); Defense Health Agency Immunization Healthcare Branch; Armed Forces Health Surveillance Branch; Naval He alth Research Center; United States Air Force School of Aerospace Medicine; Uniformed Services University of the Health Sciences Not yet recruiting (Source: ClinicalTrials.gov)

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Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) Haploinsufficiency

Conditions: CTLA4 Haplonisufficiency; Chronic Cytopernia Interventions: Drug: Orencia (abatacept); Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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PREVAIL VIII: A CoHOrt Clinical, Viral, and ImmuNOlogic Monitoring Study of People Living With Retroviral Infection in Liberia (HONOR)

Condition: HIV Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Pay-it-forward RCT for Gonorrhea and Chlamydia Testing

Seal, Stopping Atopic Dermatitis and Allergy Study

Evaluating the Safety and Pharmacokinetics of VRC-HIVMAB075-00-AB (VRC07-523LS) in the Sera and Mucosae of Healthy, HIV-Uninfected Adult Participants

Condition: HIV Infections Intervention: Biological: VRC07-523LS Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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HOPE in Action Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients

Condition: Hiv Intervention: Other: HIVD+/R+ Sponsors: Johns Hopkins University; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Eczema Reminder and Accountability Program

Conditions: Atopic Dermatitis; Eczema Intervention: Behavioral: Patient reminders and accountability questionnaires Sponsors: McMaster University; Hamilton Allergy Recruiting (Source: ClinicalTrials.gov)

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Pragmatic Assessment Study Influenza Vaccine Effectiveness in DoD

Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) Haploinsufficiency

PREVAIL VIII: A CoHOrt Clinical, Viral, and ImmuNOlogic Monitoring Study of People Living With Retroviral Infection in Liberia (HONOR)

The Atopic March and Atopic Multimorbidity: Many Trajectories, Many Pathways

The "atopic march" recognizes the increased occurrence of asthma and/or allergic rhinitis after atopic dermatitis (AD) onset. Mechanisms for developing atopic comorbidities after AD onset are poorly understood, but may involve the impaired cutaneous barrier, which facilitates cutaneous sensitization . The association may also be driven or amplified in susceptible individuals by a systemic Th2-dominant immune response to cutaneous inflammation. However, these associations may merely involve shared genetic loci and environmental triggers, including microbiome dysregulation, with the temporal sequ ence reflecting tissue-specific peak time of occurrence of each disease, suggesting more of a clustering of disorders than a march. (Source: Journal of Allergy and Clinical Immunology)

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What can urban/rural differences in food allergy prevalence tell us about the drivers of food allergy?

(Source: Journal of Allergy and Clinical Immunology)

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The Atopic March and Atopic Multimorbidity: Many Trajectories, Many Pathways

What can urban/rural differences in food allergy prevalence tell us about the drivers of food allergy?

(Source: Journal of Allergy and Clinical Immunology)

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Milk Allergy Most Common in U.S. Kids Under Age 5 Years

(MedPage Today) -- But many young children are not prescribed epinephrine (Source: MedPage Today Allergy)

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Parental Pacifier Sucking May Lower Kids' Allergy Risks

(MedPage Today) -- Lower early-life total IgE production linked to mom or dad orally " cleaning " pacifier (Source: MedPage Today Allergy)

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Milk Allergy Most Common in U.S. Kids Under Age 5 Years

(MedPage Today) -- But many young children are not prescribed epinephrine (Source: MedPage Today Allergy)

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Parental Pacifier Sucking May Lower Kids' Allergy Risks

Milk Allergy Most Common in U.S. Kids Under Age 5 Years

(MedPage Today) -- But many young children are not prescribed epinephrine (Source: MedPage Today Allergy)

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Parental Pacifier Sucking May Lower Kids' Allergy Risks

Man With Persistent Runny Nose Learns He Had Leaking Brain Fluid

Greg Phillpotts told ABC 11 that for years he believed his symptoms were due to allergies. (Source: Science - The Huffington Post)

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Milk Allergy Most Common in U.S. Kids Under Age 5 Years

(MedPage Today) -- But many young children are not prescribed epinephrine (Source: MedPage Today Allergy)

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Parental Pacifier Sucking May Lower Kids' Allergy Risks

Man With Persistent Runny Nose Learns He Had Leaking Brain Fluid

Milk Allergy Most Common in U.S. Kids Under Age 5 Years

(MedPage Today) -- But many young children are not prescribed epinephrine (Source: MedPage Today Allergy)

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Parental Pacifier Sucking May Lower Kids' Allergy Risks

Man With Persistent Runny Nose Learns He Had Leaking Brain Fluid

Milk Allergy Most Common in U.S. Kids Under Age 5 Years

(MedPage Today) -- But many young children are not prescribed epinephrine (Source: MedPage Today Allergy)

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Parental Pacifier Sucking May Lower Kids' Allergy Risks

Man With Persistent Runny Nose Learns He Had Leaking Brain Fluid

What May Happen To Allergies If You Suck On Your Infant's Pacifier

When your baby's pacifier drops to the ground, do you clean it with your mouth and put it back in the baby's mouth? Does this study really suggest that this may help prevent allergies in your baby? (Source: Forbes.com Healthcare News)

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What May Happen To Allergies If You Suck On Your Infant's Pacifier

Immunotherapy for metastatic or recurrent head and neck cancer

Immunotherapy for metastatic or recurrent head and neck cancer European Pharmaceutical ReviewImmunotherapy effective as first-line treatment for advanced head and neck cancer EurekAlert (press release)Immunotherapy effective as treatment for head and neck cancer, trial suggests The Irish NewsFull coverage

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Immunotherapy for metastatic or recurrent head and neck cancer

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What May Happen To Allergies If You Suck On Your Infant's Pacifier

Forty cases of acquired oral syphilis and a review of the literature

The aim of this study was to describe 40 cases of acquired oral syphilis (AOS) and to discuss the distribution of demographic characteristics, clinical features, and differential diagnosis of the disease. A retrospective study was conducted covering a 17-year period at a single institution in southern Brazil. Moreover, a literature review was performed through a search of the PubMed database for articles on AOS published between 1955 and March 2018. Data were analyzed descriptively. The predominant group within the case series was male patients in their twenties.

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Three-dimensional soft tissue effects of mandibular midline distraction and surgically assisted rapid maxillary expansion: an automatic stereophotogrammetry landmarking analysis

Studies on mandibular midline distraction (MMD) are mostly performed using conventional research methods. Concerning surgically assisted rapid maxillary expansion (SARME), more research is conducted using three-dimensional (3D) techniques. Research on bimaxillary expansion, the combination of MMD and SARME, is reported sparsely. The main objective of this study was to provide a 3D evaluation of soft tissue effects following SARME and/or MMD. Patients who underwent SARME and/or MMD between 2008 and 2013 were included.

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Forty cases of acquired oral syphilis and a review of the literature

Three-dimensional soft tissue effects of mandibular midline distraction and surgically assisted rapid maxillary expansion: an automatic stereophotogrammetry landmarking analysis

The Atopic March and Atopic Multimorbidity: Many Trajectories, Many Pathways

The "atopic march" recognizes the increased occurrence of asthma and/or allergic rhinitis after atopic dermatitis (AD) onset. Mechanisms for developing atopic comorbidities after AD onset are poorly understood, but may involve the impaired cutaneous barrier, which facilitates cutaneous sensitization. The association may also be driven or amplified in susceptible individuals by a systemic Th2-dominant immune response to cutaneous inflammation. However, these associations may merely involve shared genetic loci and environmental triggers, including microbiome dysregulation, with the temporal sequence reflecting tissue-specific peak time of occurrence of each disease, suggesting more of a clustering of disorders than a march.

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What can urban/rural differences in food allergy prevalence tell us about the drivers of food allergy?

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What can urban/rural differences in food allergy prevalence tell us about the drivers of food allergy?

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Patients With Food Allergies Rank Top Dining-Out Safeguards Patients With Food Allergies Rank Top Dining-Out Safeguards

People who use more preventive strategies when eating out at a restaurant reduce the risk for a reaction, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)

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Patients With Food Allergies Rank Top Dining-Out Safeguards Patients With Food Allergies Rank Top Dining-Out Safeguards

People who use more preventive strategies when eating out at a restaurant reduce the risk for a reaction, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)

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Disentangling the heterogeneity of allergic respiratory diseases by latent class analysis reveals novel phenotypes

Abstract

Background

Refined phenotyping of allergic diseases may unravel novel phenotypes. Conjunctivitis as an independent disorder has never been approached.

Aim

To identify distinct classes of allergic respiratory diseases using latent class analysis (LCA) and distinguish each class using classification and regression tree (CART) analysis.

Methods

728 adults from the Portuguese general population study ICAR had a structured medical interview combined with blood collection, skin prick tests, spirometry with bronchodilation, and exhaled nitric oxide. LCA was applied to 19 variables. The CART algorithm selected the most likely variables distinguishing LCA‐classes.

Results

A six‐class model was obtained. Class 1 (25%): non‐allergic participants without bronchial or ocular symptoms. Classes 2 (22%) and 3 (11%): nasal and ocular (low levels) symptoms without nasal impairment, monosensitized (Class 2) or polysensitized (Class 3). Class 4 (13%): polysensitized participants with high levels of nasal and ocular symptoms, and nasal impairment. Classes 5 (16%) and 6 (14%): high level of nasal, bronchial and ocular symptoms with nasal impairment (non‐allergic or polysensitized, respectively). Participants in classes 5 and 6 had more bronchial exacerbations and unscheduled medical visits (p<0.001). Ocular symptoms were significantly higher in classes with nasal impairment, compared to those without impairment (p<0.001) or no nasal symptom (p<0.001). CART highlighted ocular symptoms as the most relevant variable in distinguishing LCA‐classes.

Conclusions

Novel severe phenotypes of participants with co‐occurrence of ocular, nasal and bronchial symptoms, and exacerbation‐prone were identified. The tree algorithm showed the importance of the ocular symptoms in the expression of allergic diseases phenotypes.

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Effect of oral hygiene programmes on oral opportunistic pathogens during stroke rehabilitation

Abstract

Objectives

This study was to assess the effectiveness of a conventional oral hygiene care programme (COHCP) and an advanced oral hygiene care programme (AOHCP) on prevalence and viable counts of oral opportunistic pathogens among patients undergoing stroke rehabilitation.

Methods

A total of 94 patients were randomized to two groups. Subjects were block randomized to: either (1) COHCP: manual toothbrushing with oral hygiene instruction (OHI); or (2) AOHCP: powered toothbrushing, mouthrinsing with chlorhexidine and OHI. Prevalence and viable counts of oral opportunistic pathogens including yeasts, aerobic and facultative anaerobic gram‐negative bacilli, Staphylococcus aureus, were assessed at baseline, the end of three months, and six months.

Results

No significant difference was observed in the prevalence of oral opportunistic pathogens within each group over the clinical trial period. A significant decrease in the viable counts of S. aureus was found over the clinical trial period within AOHCP group (p<0.05), while the viable counts of yeasts and AGNB remained stable within each group. Regression analysis failed to detect an association between intervention and the prevalence/viable counts of oral opportunistic pathogens.

Conclusions

Neither oral health care programme significantly affect AGNB, yeast or S. aureus over the study period in terms of prevalence and viable counts.

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Prevalence and normative values for Jaw Functional Limitations in the general population in Sweden

Abstract

Objectives

For Jaw Functional Limitations measured by the Jaw Functional Limitation Scale (JFLS), (i) determining prevalence in the Swedish general adult population, (ii) investigating the influence of demographic factors and self‐reported dental status, and (iii) deriving normative values.

Methods

A random sample of the general adult population in Sweden was approached (response rate: 46%, N=1,372). Prevalence was determined for the JFLS summary score and individual items. The influence of age, gender, and dental status was investigated with regression analyses and normative values presented.

Results

The JFLS median score was 0 and all items had prevalences <30%. Age and gender did not influence Jaw Functional Limitations but dental status did. Normative JFLS scores were 1, 9 and 28 for the 7^th, 8^th, and 9^th decile, respectively. In dental status‐stratified norms, 9^th deciles were 20, 43, and 100, for subjects with natural teeth only, removable and complete dentures, respectively.

Conclusions

The Swedish general adult population had excellent jaw function, but dental status was major determinant. In the absence of information linking JFLS scores to important patient concerns, the score distribution can serve as a reference with the 9^th decile as threshold for functional limitation.

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Disentangling the heterogeneity of allergic respiratory diseases by latent class analysis reveals novel phenotypes

Abstract

Background

Refined phenotyping of allergic diseases may unravel novel phenotypes. Conjunctivitis as an independent disorder has never been approached.

Aim

To identify distinct classes of allergic respiratory diseases using latent class analysis (LCA) and distinguish each class using classification and regression tree (CART) analysis.

Methods

Results

Conclusions

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Effect of oral hygiene programmes on oral opportunistic pathogens during stroke rehabilitation

Abstract

Objectives

Methods

Results

Conclusions

Neither oral health care programme significantly affect AGNB, yeast or S. aureus over the study period in terms of prevalence and viable counts.

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Prevalence and normative values for Jaw Functional Limitations in the general population in Sweden

Abstract

Objectives

Methods

Results

Conclusions

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Characterization of autoantibodies in primary membranous nephropathy and their clinical significance.

Authors: Stahl RA, Reinhard L, Hoxha E Abstract INTRODUCTION: Membranous nephropathy (MN) is the most common cause of a nephrotic syndrome in Caucasian adults. The identification of target antigens in MN in the last decade has had a major impact on the clinical approach to these patients. Areas covered: Since the discoveries in animal models in the 1980s that circulating autoantibodies induce disease upon in situ binding to glomerular podocytes, many attempts have been undertaken to define the human antigens responsible for disease induction. Only in 2009 was Phospholipase A2 Receptor 1 described as the major antigen responsible for MN onset in about 70% of patients. Subsequently, in 2014 Thrombospondin Type-1 Domain-Containing 7A was identified as a second antigen, accounting for ...

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Immune Correlates of Protection Induced by Virus-Like Particles Containing 2009 H1N1 Pandemic Influenza HA, NA or M1 Proteins.

In this study, we generated VLPs containing hemagglutinin (HA), neuraminidase (NA) or M1 proteins derived from the A/California/04/09. Mice were immunized intramuscularly with HA-M1, NA-M1 or M1 VLPs and protective immunity was evaluated by assessing lung virus loads against low (5LD50) or high (100LD50) lethal dose of homologous virus challenges. High levels of virus-specific serum IgG antibody responses were induced in mice after HA-M1 VLPs immunization, whereas low or no IgG antibody responses were detected from immunization with NA-M1 VLPs or M1 VLPs, independently. Mice that were immunized with HA-M1 VLPs showed below the limit of detection on lung virus loads against low dose (5LD50) of challenge and significant reduction against high dose (100LD50) of challenge infection. Mice that ...

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Differential Diagnosis of Cheilitis - How to Classify Cheilitis?

Authors: Lugović-Mihić L, Pilipović K, Crnarić I, Šitum M, Duvančić T Abstract Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. The disease may appear as an isolated condition or as part of certain systemic diseases/conditions (such as anemia due to vitamin B12 or iron deficiency) or local infections (e.g., herpes and oral candidiasis). Cheilitis can also be a symptom of a contact reaction to an irritant or allergen, or may be provoked by sun exposure (actinic cheilitis) or drug intake, especially retinoids. Generally, the forms most commonly reported in the literature are angular, contact (allergic and irritant), actinic, glandul...

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Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience.

Authors: Jelušić M, Kronja M, Frković M, Sršen S, Huljev Frković S, Štekić Novački K Abstract Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic juvenile idiopathic arthritis (sJIA), caused by exaggerated but ineffective immune response. The aim of the study was to compare the capacity of the HLH-2004 guidelines with the capacity of the MAS guidelines from 2005, and with the new set of classification criteria from 2016 in diagnosing MAS complicating sJIA. The study included 35 children aged 1-18 diagnosed with sJIA according to ILAR criteria and treated at the Department of Pediatrics, Division of Immunology and Rheu-matology, Zagreb University Hospital Centre, in the period from 2009 to 2015. Out of 35 patients diagnosed with sJIA, there w...

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There is limited existing evidence to support the common assumption that strenuous endurance exercise bouts impair immune competency.

Authors: Campbell JP, Turner JE PMID: 30430884 [PubMed - as supplied by publisher] (Source: Expert Review of Clinical Immunology)

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Characterization of autoantibodies in primary membranous nephropathy and their clinical significance.

Immune Correlates of Protection Induced by Virus-Like Particles Containing 2009 H1N1 Pandemic Influenza HA, NA or M1 Proteins.

Differential Diagnosis of Cheilitis - How to Classify Cheilitis?

Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience.

Patients With Food Allergies Rank Top Dining-Out Safeguards Patients With Food Allergies Rank Top Dining-Out Safeguards

People who use more preventive strategies when eating out at a restaurant reduce the risk for a reaction, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)

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Patients With Food Allergies Rank Top Dining-Out Safeguards Patients With Food Allergies Rank Top Dining-Out Safeguards

People who use more preventive strategies when eating out at a restaurant reduce the risk for a reaction, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)

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Issue Information

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Issue Information

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Sawyer to state: Explain Mooresville cancer cases

Sawyer to state: Explain Mooresville cancer cases Mooresville TribuneFull coverage

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Sawyer to state: Explain Mooresville cancer cases

Sawyer to state: Explain Mooresville cancer cases Mooresville TribuneFull coverage

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Individual Risk Assessment Tool for School Age Asthma Prediction in UK Birth Cohort

ConclusionMAAS APT is a simple asthma prediction tool which could easily be applied in clinical and research settings.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)

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Upregulation of tumor PD-L1 by neoadjuvant chemoradiotherapy (neoCRT) confers improved survival in patients with lymph node metastasis of locally advanced rectal cancers

In this study, we examined the roles of tumor PD-L1 and IFN-γ before and after neoCRT in locally advanced rectal cancer (LARC) patients. Our results demonstrate that patients with high PD-L1 expression in post-neoCRT tissues exhibit improved 5-year disease-free survival (DFS) and overall survival (OS) compared with those with low PD-L1 e xpression (p < 0.001). Furthermore, in the pN+ population, patients with high PD-L1 expression in post-neoCRT tissues exhibit improved 5-year DFS and OS. PD-L1 and IFN-γ upregulation increased in tumor tissues after neoCRT, and patients with high PD-L1 and high IFN-γ exhibit improved 5-year DFS and OS (p = 0.04 andp = 0.001, respectively). To the best of our knowledge, this study is the first to demonstrate that PD-L1 upregulation in a...

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Current therapeutical strategies for allergic rhinitis.

Authors: Klimek L, Sperl A, Becker S, Mösges R, Tomazic PV Abstract INTRODUCTION: Allergic rhinitis is a common condition with increasing prevalence and is associated with several comorbid disorders such as bronchial asthma and atopic dermatitis. If allergen avoidance is not possible, allergen-specific immunotherapy is the only causal treatment option. Areas covered: This review focuses on current treatments and the future outlook for allergic rhinitis. Pharmacotherapy includes mast cell stabilizers, antihistamines, glucocorticosteroids (GCSs), leukotriene receptor antagonists, and nasal decongestants. Nasal GCSs are currently regarded as the most effective treatment and are considered first-line therapy together with non-sedating antihistamines. The new formulation MP29-02 combin...

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Current therapeutical strategies for allergic rhinitis.

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Activation of Toll ‐like receptor 7 signaling in labial salivary glands of primary Sjögren's syndrome patients

ConclusionOur findings suggest that TLR7 is dominantly expressed in both MNCs and ducts with downstream signals for type I IFNs, indicating that TLR7 ‐dominant innate immunity is related to the development of sialadenitis in pSS.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)

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Upregulation of tumor PD-L1 by neoadjuvant chemoradiotherapy (neoCRT) confers improved survival in patients with lymph node metastasis of locally advanced rectal cancers

Regulatory T Cell Plasticity and Stability and Autoimmune Diseases

AbstractCD4+CD25+ regulatory T cells (Tregs) are a class of CD4+ T cells with immunosuppressive functions that play a critical role in maintaining immune homeostasis. However, in certain disease settings, Tregs demonstrate plastic differentiation, and the stability of these Tregs, which is characterized by the stable expression or protective epigenetic modifications of the transcription factor Foxp3, becomes abnormal. Plastic Tregs have some features of helper T (Th) cells, such as the secretion of Th-related cytokines and the expression of specific transcription factors in Th cells, but also still retain the expression of Foxp3, a feature of Tregs. Although such Th-like Tregs can secrete pro-inflammatory cytokines, they still possess a strong ability to inhibit specific Th cell responses....

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Regulatory T Cell Plasticity and Stability and Autoimmune Diseases

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Prostaglandin E2 decrease in induced sputum of hypersensitive asthmatics during oral challenge with aspirin

ConclusionsAspirin ‐precipitated bronchoconstriction is associated with a decrease in airway PGE2 biosynthesis. These results support the mechanism of PGE2 biosynthesis inhibition as a trigger for bronchoconstriction in NERD.This article is protected by copyright. All rights reserved. (Source: Allergy)

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Circulating natural antibodies to inflammatory cytokines are potential biomarkers for atherosclerosis

Inflammatory cytokines contribute to the development of atherosclerosis. Natural antibodies in the circulation have protective effects on common diseases including atherosclerosis-related conditions. (Source: Journal of Inflammation)

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Circulating natural antibodies to inflammatory cytokines are potential biomarkers for atherosclerosis

Contribution of the inflammasome to inflammaging

Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer 's d... (Source: Journal of Inflammation)

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Mechanisms of lymphatic system –specific viral replication and its potential role in autoimmune disease

In conclusion, several mechanisms promote viral replication in secondary lymphatic organs. Identifying such factors in humans is a challenge for future studies.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)

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Individual Risk Assessment Tool for School Age Asthma Prediction in UK Birth Cohort

Essentia Health offers way to quit smoking for better health

Essentia Health offers way to quit smoking for better health Brainerd Dispatch43RD GREAT AMERICAN SMOKEOUT HAPPENING THURSDAY kqennewsradio.comFull coverage

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Essentia Health offers way to quit smoking for better health

Essentia Health offers way to quit smoking for better health Brainerd Dispatch43RD GREAT AMERICAN SMOKEOUT HAPPENING THURSDAY kqennewsradio.comFull coverage

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Can EpiPens Still Work After Freezing?

Title: Can EpiPens Still Work After Freezing?Category: Health NewsCreated: 11/16/2018 12:00:00 AMLast Editorial Review: 11/16/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Many Infants With Milk Allergy Seem to Outgrow It

Title: Many Infants With Milk Allergy Seem to Outgrow ItCategory: Health NewsCreated: 11/16/2018 12:00:00 AMLast Editorial Review: 11/16/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Climate Change Could Change the Ragweed Sneezin' Season

Title: Climate Change Could Change the Ragweed Sneezin' SeasonCategory: Health NewsCreated: 11/15/2018 12:00:00 AMLast Editorial Review: 11/16/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Dining Out With Allergies Is Tough, But These Steps Can Help

Title: Dining Out With Allergies Is Tough, But These Steps Can HelpCategory: Health NewsCreated: 11/16/2018 12:00:00 AMLast Editorial Review: 11/16/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Can EpiPens Still Work After Freezing?

Title: Can EpiPens Still Work After Freezing?Category: Health NewsCreated: 11/16/2018 12:00:00 AMLast Editorial Review: 11/16/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Climate Change Could Change the Ragweed Sneezin' Season

Dining Out With Allergies Is Tough, But These Steps Can Help

The intersection of affinity and specificity in the development and optimization of T cell receptor based therapeutics

Publication date: December 2018Source: Seminars in Cell & Developmental Biology, Volume 84Author(s): Timothy P. Riley, Brian M. BakerAbstractThe role of the αβ T cell receptor (TCR) in identifying immunological targets and signaling appropriate responses provides for exciting translational opportunities. Yet TCRs mediate one of the most complex protein–protein interactions in biology, with intricate signaling and selection mechanisms adding additional layers of sophistication. In this review, we discuss how these complexities influence the development and optimization of TCR-based therapeutics, focusing on the intersection between structure, affinity, and specificity. We highlight similarities between TCRs and germline antibodies in molecular recognition, but emphasize that engineering...

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The intersection of affinity and specificity in the development and optimization of T cell receptor based therapeutics

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Improvement of protein quality and degradation of allergen in soybean meal fermented by Neurospora crassa

Publication date: March 2019Source: LWT, Volume 101Author(s): Jing Li, Ruo-lin Zhou, Zhi-qing Ren, Ya-wei Fan, Sheng-ben Hu, Cheng-fei Zhuo, Ze-yuan DengAbstractThe nutrition quality and bioactivity of soybean meal was investigated via solid-state fermentation using Neurospora crassa (NC) alone or Neurospora crassa and saccharomyces cerevisiae (NCSC) together. The optimized fermentation conditions of NC or NCSC were obtained as follow: fermentation temperature (30 °C both), fermentation time (72 h vs 74.7 h), solid-liquid ratio [1:3.5 vs 1:3.0 (g/mL)], inoculation amount (the inoculation amount of fungi/soybean meal (dry weight)) of Neurospora crassa + Saccharomyces [1% (m/m)+0 vs 1% (m/m) +20% (v/m)], initial pH (7.0 both). The protein hydrolysis of fermented soybean meal (FSM) c...

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Improvement of protein quality and degradation of allergen in soybean meal fermented by Neurospora crassa

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Prognostic Value of Serum Liver Enzymes in Oral and Oropharynx Squamous Cell Carcinomas

Abstract

Background

Serum liver enzymes, which catalyze relevant catabolic pathways, have been indicated to be diagnostic and prognostic tools for several malignant tumors. The correlation between serum liver enzymes levels and survival in patients with oral and oropharynx squamous cell carcinomas (OSCC) is still absent. Here, we conducted a study focusing on predictive value of serum liver enzymes in terms of prognosis in the patients.

Methods

A retrospective study including 134 OSCC patients from years 2009 to 2014 was performed to investigate the association between levels of pretreatment serum liver enzymes, various clinical parameters and prognostic outcomes, which are overall survival (OS) and disease‐free survival (DFS). Log‐rank tests with Kaplan‐Meier method were used to detect potential prognostic biomarkers. Multivariate analyses by Cox proportional hazards model were used to identify significant predictors of prognosis.

Results

Serum adenosine deaminase (ADA) level was associated with patients' OS and DFS by univariate analyses (P = 0.006 and P = 0.024, respectively). Multivariate analyses showed that higher serum ADA (>17.2 μmol/L) (P = 0.019) as well as positive lymph node status (P = 0.035) independently predicted worse OS of patients with OSCC. In addition, older age (≥ 60 years) (P = 0.043) and positive lymph node status (P = 0.027) were independently prognostic parameters for poorer DFS.

Conclusions

Preoperative serum ADA levels may serve as a reliable independent prognostic predictor for OS in OSCC patients.

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Prognostic Value of Serum Liver Enzymes in Oral and Oropharynx Squamous Cell Carcinomas

Abstract

Background

Methods

Results

Conclusions

Preoperative serum ADA levels may serve as a reliable independent prognostic predictor for OS in OSCC patients.

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LncRNA LINC00974 activates TGF‐β/Smad signaling to promote oral fibrogenesis

Abstract

Background

Oral submucous fibrosis (OSF) is a progressive scarring disease and has been considered as a premalignant condition of the oral cavity. However, the detailed molecular mechanisms underlying the pathogenesis of OSF are still unclear.

Method

Here, we examined the expression of a novel long non‐coding RNA LINC00974 in OSF and investigated its function role in myofibroblast transdifferentiation. Phenotypic analyses, including collagen gel contraction, migration, invasion and wound healing assays, were used to assess the myofibroblast activities following overexpression or inhibition of LINC00974.

Results

We found that the expression of LINC00974 in OSF tissues or myofibroblasts was aberrantly upregulated, and there was a positive correlation between LINC00974 and myofibroblast markers. Our results showed that inhibition of LINC00974 suppressed the myofibroblast activities, while overexpression of LINC00974 increased the activation. We demonstrated that the expression levels of α‐SMA, α‐1 type I collagen, fibronectin were downregulated in the LINC00974‐inhibited myofibroblasts. Additionally, the TGF‐β secretion and phosphorylated Smad2 expression were also repressed in the LINC00974‐inhibited myofibroblasts. We further demonstrated that silence of LINC00974 prevented the arecoline‐induced myofibroblast activation, and LINC00974‐increased myofibroblast activities were via TGF‐β pathway.

Conclusion

Altogether, these findings suggested that arecoline‐increased myofibroblast transdifferentiation was via LINC00974‐mediated activation of TGF‐β signaling.

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LncRNA LINC00974 activates TGF‐β/Smad signaling to promote oral fibrogenesis

Abstract

Background

Method

Results

Conclusion

Altogether, these findings suggested that arecoline‐increased myofibroblast transdifferentiation was via LINC00974‐mediated activation of TGF‐β signaling.

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Can EpiPens Still Work After Freezing?

Title: Can EpiPens Still Work After Freezing?Category: Health NewsCreated: 11/16/2018 12:00:00 AMLast Editorial Review: 11/16/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Can EpiPens Still Work After Freezing?

Title: Can EpiPens Still Work After Freezing?Category: Health NewsCreated: 11/16/2018 12:00:00 AMLast Editorial Review: 11/16/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Many Infants With Milk Allergy Seem to Outgrow It

Climate Change Could Change the Ragweed Sneezin' Season

Dining Out With Allergies Is Tough, But These Steps Can Help

Expression of Toll-like receptors 2, 4 and 6 in the equine chorioallantois

This study examined the expression of TLR 2, 4 and 6 as transcript and protein in the placenta (chorioallantois) of 14 foals born alive. By PCR, all examined placental samples contained TLR 2, 4 and 6 transcripts. Using immunohistochemistry, trophoblasts and allantoic epithelium were immunopositive for TLR 2, 4 and 6 in all placental samples. The majority of placental samples contained TLR 4 and 6 positive stromal cells and vascular smooth muscle cells. Since these results confirm the expression of TLR 2, 4 and 6 in different cell populations of the equine placenta, they are the basis for studies into the pathogenesis of TLR-associated placental diseases in mares. (Source: Veterinary Immunology and Immunopathology)

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25(OH)D serum concentration in women with menstrual disorders -risk factors for Vitamin D deficiency.

CONCLUSIONS: Thorough assessment of vitamin D deficiency/insufficiency is required among patients with menstrual disorders, especially those overweighed and obese. Early screening and VD supplementation in women with estrogen-dependent disorders may become a part of routine management in order to optimize endocrine health. PMID: 30431736 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)

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Towards a better understanding of allograft-induced stress response in the pearl oyster Pinctada fucata martensii: Insights from iTRAQ-based comparative proteomic analysis

In this study, we took advantage of the iTRAQ-based proteomics and LC-MS/MS approach to look into allograft induced gene regulation at the protein expression level in the pearl oyster Pinctada fucata martensii, across a period of 30 days following nucleus implantation. A wide variety of proteins, including a group of immune-related proteins such as E3 ubiquitin-ligase and heat shock proteins, exhibited differential expression in response to the surgical operation. Further comparisons between different sampling points revealed that GO terms including "translation" and "oxidation-reduction process" and KEGG pathways including "glycolysis/gluconeogenesis" and "pyruvate metabolism" were significantly enriched at several time points, indicating the important roles of these molec...

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Local regulation of immune genes in rainbow trout (Oncorhynchus mykiss) naturally infected with Flavobacterium psychrophilum

Publication date: March 2019Source: Fish & Shellfish Immunology, Volume 86Author(s): Estefanía Muñoz-Atienza, Carlos Távara, Patricia Díaz-Rosales, Luis Llanco, Enrique Serrano-Martínez, Carolina TafallaAbstractFlavobacterium psychrophilum is the etiological agent of bacterial cold water disease (BCWD), also referred to as rainbow trout fry syndrome (RTFS), a disease with great economic impact in salmonid aquaculture. Despite this, to date, not many studies have analyzed in depth how the immune system is regulated during the course of the disease. In the current study, we have studied the transcription of several immune genes related to T and B cell activity in the skin of rainbow trout (Oncorhynchus mykiss) naturally infected with F. psychrophilum in a farm located in Lake Titicaca (...

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Viruses, Vol. 10, Pages 646: Human Fetal Astrocytes Infected with Zika Virus Exhibit Delayed Apoptosis and Resistance to Interferon: Implications for Persistence

Authors: Daniel Limonta Juan Jovel Anil Kumar Adriana M. Airo Shangmei Hou Leina Saito William Branton Gane Ka-Shu Wong Andrew Mason Christopher Power Tom C. Hobman Zika virus (ZIKV) infection and persistence during pregnancy can lead to microcephaly and other fetal neurological disorders collectively known as Congenital Zika Syndrome. The immunological and virological events that contribute to the establishment of persistent ZIKV infection in humans are unclear though. Here we show that human fetal astrocytes (HFAs), the most abundant cell type in the central nervous system, become persistently infected with ZIKV resulting in continuous viral shedding for at least one month; a process that is facilitated by TIM/TAM receptors. HFAs are relatively resistant to ZIKV...

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Expression of Toll-like receptors 2, 4 and 6 in the equine chorioallantois

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25(OH)D serum concentration in women with menstrual disorders -risk factors for Vitamin D deficiency.

Towards a better understanding of allograft-induced stress response in the pearl oyster Pinctada fucata martensii: Insights from iTRAQ-based comparative proteomic analysis

Local regulation of immune genes in rainbow trout (Oncorhynchus mykiss) naturally infected with Flavobacterium psychrophilum

Viruses, Vol. 10, Pages 646: Human Fetal Astrocytes Infected with Zika Virus Exhibit Delayed Apoptosis and Resistance to Interferon: Implications for Persistence

Individual Risk Assessment Tool for School Age Asthma Prediction in UK Birth Cohort

Abstract

Background

Current published asthma predictive tools have moderate positive likelihood ratios (LR+) but high negative likelihood ratios (‐LR) based on their recommended cut‐offs, which limit their clinical usefulness.

Objective

To develop a simple clinically applicable asthma prediction tool within a population‐based birth cohort.

Method

Children from the Manchester Asthma and Allergy Study (MAAS) attended follow‐up at ages 3, 8 and 11 years. Data on pre‐school wheeze was extracted from primary‐care records. Parents completed validated respiratory questionnaires. Children were skin prick tested (SPT). Asthma at 8/11 years (school ‐age) was defined as parentally‐reported (1) physician‐diagnosed asthma and wheeze in the previous 12 months or (2) ≥3 wheeze attacks in the previous 12 months. An asthma prediction tool (MAAS APT) was developed using logistic regression of characteristics at age 3 years to predict school‐age asthma.

Results

Of 336 children with physician‐confirmed wheeze by age 3 years, 117(35%) had school‐age asthma. Logistic regression selected 5 significant risk factors which formed the basis of the MAAS APT: wheeze after exercise; wheeze causing breathlessness; cough on exertion; current eczema and SPT sensitisation(maximum score 5). A total of 281(84%) children had complete data at age 3 years and were used to test the MAAS APT. Children scoring ≥3 were at high risk of having asthma at school‐age(PPV>75%; +LR 6.3,‐LR 0.6), whereas children who had a score of 0 had very low risk(PPV 9.3%; LR 0.2).

Conclusion

MAAS APT is a simple asthma prediction tool which could easily be applied in clinical and research settings.

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Individual Risk Assessment Tool for School Age Asthma Prediction in UK Birth Cohort

Abstract

Background

Objective

To develop a simple clinically applicable asthma prediction tool within a population‐based birth cohort.

Method

Results

Conclusion

MAAS APT is a simple asthma prediction tool which could easily be applied in clinical and research settings.

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Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity

Abstract

Background

Optimal treatment and prognostic factors affecting long‐term survival in patients with sinonasal adenoid cystic carcinoma (ACC) have yet to be clearly defined.

Methods

We conducted a retrospective review of patients treated with curative intent from 1980‐2015 at MD Anderson Cancer Center.

Results

One hundred sixty patients met inclusion criteria, including 8 who were treated with radiotherapy alone. Median follow‐up time was 55 months. The 5‐year overall survival (OS) and disease‐free survival (DFS) rates were 67.0% and 49.0%, respectively. The 10‐year OS and DFS rates were 44.8% and 25.4%, respectively. Factors that portended for poor survival on multivariate analysis were recurrent disease, any solid type histology, epicenter in the sinus cavity, the presence of facial symptoms, or the original disease not treated with surgery. There was no association between surgical margin status or nodal status and survival.

Conclusion

In this large cohort of patients with sinonasal ACC with extended follow‐up, long‐term survival is better than reported in prior literature. Future research should target patients with adverse risk factors.

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Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity

Abstract

Background

Optimal treatment and prognostic factors affecting long‐term survival in patients with sinonasal adenoid cystic carcinoma (ACC) have yet to be clearly defined.

Methods

We conducted a retrospective review of patients treated with curative intent from 1980‐2015 at MD Anderson Cancer Center.