Παρασκευή 26 Οκτωβρίου 2018
Acknowledgment of Reviewers 2016 and 2017
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Acknowledgment of Reviewers 2016 and 2017
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Speech Understanding and Sound Localization with a New Nonimplantable Wearing Option for Baha.
Conclusions: Bone conduction sound processor mounted on a SoundArc or on a softband resulted in considerable improvements in hearing and speech understanding in subjects with a simulated, purely conductive, and bilateral hearing loss. No significant difference between the 2 wearing options was found. Using 2 sound processors improves sound localization and speech understanding in noise in certain spatial settings. PMID: 30356363 [PubMed - in process] (Source: Biomed Res)
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Development of Phonological, Lexical, and Syntactic Abilities in Children With Cochlear Implants Across the Elementary Grades
Conclusions Congenital hearing loss puts children at continued risk of language deficits, especially for phonologically based skills. Two interventions that appear to ameliorate that risk are providing a period of bimodal stimulation and strong literacy instruction. (Source: Journal of Speech, Language, and Hearing Research)
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Speech Understanding and Sound Localization with a New Nonimplantable Wearing Option for Baha.
Conclusions: Bone conduction sound processor mounted on a SoundArc or on a softband resulted in considerable improvements in hearing and speech understanding in subjects with a simulated, purely conductive, and bilateral hearing loss. No significant difference between the 2 wearing options was found. Using 2 sound processors improves sound localization and speech understanding in noise in certain spatial settings. PMID: 30356363 [PubMed - in process] (Source: Biomed Res)
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Development of Phonological, Lexical, and Syntactic Abilities in Children With Cochlear Implants Across the Elementary Grades
Conclusions Congenital hearing loss puts children at continued risk of language deficits, especially for phonologically based skills. Two interventions that appear to ameliorate that risk are providing a period of bimodal stimulation and strong literacy instruction. (Source: Journal of Speech, Language, and Hearing Research)
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Anlotinib for the Treatment of Patients with Locally Advanced or Metastatic Medullary Thyroid Cancer
Thyroid, Ahead of Print.
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Fear of Recurrence and View of Life Affect Health-Related Quality of Life in Patients with Differentiated Thyroid Carcinoma: A Prospective Swedish Population-Based Study
Thyroid, Ahead of Print.
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Anlotinib for the Treatment of Patients with Locally Advanced or Metastatic Medullary Thyroid Cancer
Thyroid, Ahead of Print.
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Fear of Recurrence and View of Life Affect Health-Related Quality of Life in Patients with Differentiated Thyroid Carcinoma: A Prospective Swedish Population-Based Study
Thyroid, Ahead of Print.
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Anlotinib for the Treatment of Patients with Locally Advanced or Metastatic Medullary Thyroid Cancer
Thyroid, Ahead of Print.
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Fear of Recurrence and View of Life Affect Health-Related Quality of Life in Patients with Differentiated Thyroid Carcinoma: A Prospective Swedish Population-Based Study
Thyroid, Ahead of Print.
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Anlotinib for the Treatment of Patients with Locally Advanced or Metastatic Medullary Thyroid Cancer
Thyroid, Ahead of Print.
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Fear of Recurrence and View of Life Affect Health-Related Quality of Life in Patients with Differentiated Thyroid Carcinoma: A Prospective Swedish Population-Based Study
Thyroid, Ahead of Print.
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Fear of Recurrence and View of Life Affect Health-Related Quality of Life in Patients with Differentiated Thyroid Carcinoma: A Prospective Swedish Population-Based Study
Thyroid, Ahead of Print.
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Anlotinib for the Treatment of Patients with Locally Advanced or Metastatic Medullary Thyroid Cancer
Thyroid, Ahead of Print.
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Anlotinib for the Treatment of Patients with Locally Advanced or Metastatic Medullary Thyroid Cancer
Thyroid, Ahead of Print.
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Fear of Recurrence and View of Life Affect Health-Related Quality of Life in Patients with Differentiated Thyroid Carcinoma: A Prospective Swedish Population-Based Study
Thyroid, Ahead of Print.
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Impact of cochlear implantation on peripheral vestibular function in adults
ConclusionsIn the medium term, although older subjects more frequently presented vestibular disorder, cochlear implantation induced little vertigo or balance disorder, sometimes even improving vestibular function. However, vestibular disorders were frequent preoperatively and increased postoperatively. We tested vestibular function on different stimulation frequencies and yet found no correlation between postoperative test results and postoperative vertigo. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)
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Impact of cochlear implantation on peripheral vestibular function in adults
ConclusionsIn the medium term, although older subjects more frequently presented vestibular disorder, cochlear implantation induced little vertigo or balance disorder, sometimes even improving vestibular function. However, vestibular disorders were frequent preoperatively and increased postoperatively. We tested vestibular function on different stimulation frequencies and yet found no correlation between postoperative test results and postoperative vertigo. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)
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Integrins αvβ5 and αvβ6 Mediate IL-4-Induced Collective Migration in Human Airway Epithelial Cells.
Authors: Lee SN, Ahn JS, Lee SG, Park JA, Lee HS, Choi AMK, Yoon JH Abstract A positive link between persistent cellular motion and a defective tight junction (TJ) barrier allows increased antigenic penetration and contact between ligand/receptor pairs, leading to exacerbated allergic airway inflammation and remodeling. Given that collective cell migration involves cell-cell and cell-extracellular matrix (ECM) adhesions, and that interleukin-4 (IL-4) induces epithelial barrier dysfunction and decreases cell-ECM adhesions, we hypothesized that IL-4 may induce collective migration in the well-differentiated primary human nasal epithelial cells (HNECs). Well-differentiated HNECs were treated with IL-4 and the effects of IL-4 on cell migration were investigated using genetic and pharma...
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Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite induced murine asthma model.
CONCLUSIONS AND CLINICAL RELEVANCE: This study suggests that kininogen could contribute to HDM induced rise in Penh independently of allergic lung inflammation. Further research is warranted to confirm these data using invasive measurements of airway responsiveness. PMID: 30358441 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
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Integrins αvβ5 and αvβ6 Mediate IL-4-Induced Collective Migration in Human Airway Epithelial Cells.
Authors: Lee SN, Ahn JS, Lee SG, Park JA, Lee HS, Choi AMK, Yoon JH Abstract A positive link between persistent cellular motion and a defective tight junction (TJ) barrier allows increased antigenic penetration and contact between ligand/receptor pairs, leading to exacerbated allergic airway inflammation and remodeling. Given that collective cell migration involves cell-cell and cell-extracellular matrix (ECM) adhesions, and that interleukin-4 (IL-4) induces epithelial barrier dysfunction and decreases cell-ECM adhesions, we hypothesized that IL-4 may induce collective migration in the well-differentiated primary human nasal epithelial cells (HNECs). Well-differentiated HNECs were treated with IL-4 and the effects of IL-4 on cell migration were investigated using genetic and pharma...
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Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite induced murine asthma model.
CONCLUSIONS AND CLINICAL RELEVANCE: This study suggests that kininogen could contribute to HDM induced rise in Penh independently of allergic lung inflammation. Further research is warranted to confirm these data using invasive measurements of airway responsiveness. PMID: 30358441 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
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Conventional Amplification for Children and Adults with Severe-to-Profound Hearing Loss
Semin Hear 2018; 39: 364-376
DOI: 10.1055/s-0038-1670699
The primary goal of amplification is to restore audibility without causing discomfort; for someone with severe-to-profound hearing loss, the reduced dynamic range poses unique challenges in hearing-assistive device fitting. These challenges, including physiological limitation, processing difficulties, technology constraints, and other confounding factors, must be considered when selecting, fitting, and counseling for appropriate amplification. Many of the advanced features in hearing aids do not adequately address the unique characteristics of patients with severe-to-profound hearing loss. This review article will attempt to unravel some of the challenges and associated considerations when fitting adults and children with severe-to-profound hearing loss.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Conventional Amplification for Children and Adults with Severe-to-Profound Hearing Loss
Semin Hear 2018; 39: 364-376
DOI: 10.1055/s-0038-1670699
The primary goal of amplification is to restore audibility without causing discomfort; for someone with severe-to-profound hearing loss, the reduced dynamic range poses unique challenges in hearing-assistive device fitting. These challenges, including physiological limitation, processing difficulties, technology constraints, and other confounding factors, must be considered when selecting, fitting, and counseling for appropriate amplification. Many of the advanced features in hearing aids do not adequately address the unique characteristics of patients with severe-to-profound hearing loss. This review article will attempt to unravel some of the challenges and associated considerations when fitting adults and children with severe-to-profound hearing loss.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Important Information Regarding Continuing Education Units for Seminars in Hearing through AAA and ASHA
Semin Hear 2018; 39: 345-346
DOI: 10.1055/s-0038-1675567
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
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Important Information Regarding Continuing Education Units for Seminars in Hearing through AAA and ASHA
Semin Hear 2018; 39: 345-346
DOI: 10.1055/s-0038-1675567
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
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Electric and Acoustic Stimulation in Cochlear Implant Recipients with Hearing Preservation
Semin Hear 2018; 39: 414-427
DOI: 10.1055/s-0038-1670707
Hearing loss affects 30 million people in the United States, and a subset of these patients have normal low-frequency hearing and ski-sloped high-frequency hearing loss. For these patients, hearing aids alone may not provide adequate benefit. Cochlear implantation alone has been utilized to improve speech perception. The addition of high-frequency electric hearing to low-frequency acoustic hearing in these patients is beneficial. Technical improvements have allowed preservation of low-frequency hearing in cochlear implant recipients, allowing for electric and acoustic stimulation in the same ear with significant improvements in speech perception, sound localization, music appreciation, and quality of life.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Consequences and Treatment Options for Severe-to-Profound Hearing Loss
Semin Hear 2018; 39: 347-348
DOI: 10.1055/s-0038-1670701
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
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The Use of Frequency Lowering Technology in the Treatment of Severe-to-Profound Hearing Loss: A Review of the Literature and Candidacy Considerations for Clinical Application
Semin Hear 2018; 39: 377-389
DOI: 10.1055/s-0038-1670700
This article provides a review of the current literature on the topic of frequency lowering hearing aid technology specific to the treatment of severe and profound levels of hearing impairment in child and adult listeners. Factors to consider when assessing listener candidacy for frequency lowering technology are discussed. These include factors related to audiometric assessment, the listener, the type of hearing aid technology, and the verification and validation procedures that can assist in determining candidacy for frequency lowering technology. An individualized candidacy assessment including the use of real-ear verification measures and carefully chosen validation tools are recommended for listeners requiring greater audibility of high-frequency sounds, when compared with amplification via conventional hearing aid technology.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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The Use of Frequency Lowering Technology in the Treatment of Severe-to-Profound Hearing Loss: A Review of the Literature and Candidacy Considerations for Clinical Application
Semin Hear 2018; 39: 377-389
DOI: 10.1055/s-0038-1670700
This article provides a review of the current literature on the topic of frequency lowering hearing aid technology specific to the treatment of severe and profound levels of hearing impairment in child and adult listeners. Factors to consider when assessing listener candidacy for frequency lowering technology are discussed. These include factors related to audiometric assessment, the listener, the type of hearing aid technology, and the verification and validation procedures that can assist in determining candidacy for frequency lowering technology. An individualized candidacy assessment including the use of real-ear verification measures and carefully chosen validation tools are recommended for listeners requiring greater audibility of high-frequency sounds, when compared with amplification via conventional hearing aid technology.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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The Physiologic and Psychophysical Consequences of Severe-to-Profound Hearing Loss
Semin Hear 2018; 39: 349-363
DOI: 10.1055/s-0038-1670698
Substantial loss of cochlear function is required to elevate pure-tone thresholds to the severe hearing loss range; yet, individuals with severe or profound hearing loss continue to rely on hearing for communication. Despite the impairment, sufficient information is encoded at the periphery to make acoustic hearing a viable option. However, the probability of significant cochlear and/or neural damage associated with the loss has consequences for sound perception and speech recognition. These consequences include degraded frequency selectivity, which can be assessed with tests including psychoacoustic tuning curves and broadband rippled stimuli. Because speech recognition depends on the ability to resolve frequency detail, a listener with severe hearing loss is likely to have impaired communication in both quiet and noisy environments. However, the extent of the impairment varies widely among individuals. A better understanding of the fundamental abilities of listeners with severe and profound hearing loss and the consequences of those abilities for communication can support directed treatment options in this population.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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The Physiologic and Psychophysical Consequences of Severe-to-Profound Hearing Loss
Semin Hear 2018; 39: 349-363
DOI: 10.1055/s-0038-1670698
Substantial loss of cochlear function is required to elevate pure-tone thresholds to the severe hearing loss range; yet, individuals with severe or profound hearing loss continue to rely on hearing for communication. Despite the impairment, sufficient information is encoded at the periphery to make acoustic hearing a viable option. However, the probability of significant cochlear and/or neural damage associated with the loss has consequences for sound perception and speech recognition. These consequences include degraded frequency selectivity, which can be assessed with tests including psychoacoustic tuning curves and broadband rippled stimuli. Because speech recognition depends on the ability to resolve frequency detail, a listener with severe hearing loss is likely to have impaired communication in both quiet and noisy environments. However, the extent of the impairment varies widely among individuals. A better understanding of the fundamental abilities of listeners with severe and profound hearing loss and the consequences of those abilities for communication can support directed treatment options in this population.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Bimodal Hearing in Individuals with Severe-to-Profound Hearing Loss: Benefits, Challenges, and Management
Semin Hear 2018; 39: 405-413
DOI: 10.1055/s-0038-1670706
Binaural hearing offers numerous advantages over monaural hearing. While bilateral implants are a successful treatment option for some patients, many individuals choose to achieve binaural hearing by using a cochlear implant with a contralateral hearing aid. Compared with monaural hearing, benefits of bimodal hearing include improved speech perception in quiet and in noise, improved localization, and more natural sound quality. Despite the advantages, there exist disadvantages to bimodal hearing, primarily related to binaural integration. Management of these devices can be challenging in that the hearing aid and cochlear implant may be managed by different clinicians. When fitting devices, strategies are recommended to optimize the integration of input from both devices. In managing bimodal devices, recommended outcomes measures include those that would reflect bimodal benefit, such as speech understanding in noise and spatial sound quality perception.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Bimodal Hearing in Individuals with Severe-to-Profound Hearing Loss: Benefits, Challenges, and Management
Semin Hear 2018; 39: 405-413
DOI: 10.1055/s-0038-1670706
Binaural hearing offers numerous advantages over monaural hearing. While bilateral implants are a successful treatment option for some patients, many individuals choose to achieve binaural hearing by using a cochlear implant with a contralateral hearing aid. Compared with monaural hearing, benefits of bimodal hearing include improved speech perception in quiet and in noise, improved localization, and more natural sound quality. Despite the advantages, there exist disadvantages to bimodal hearing, primarily related to binaural integration. Management of these devices can be challenging in that the hearing aid and cochlear implant may be managed by different clinicians. When fitting devices, strategies are recommended to optimize the integration of input from both devices. In managing bimodal devices, recommended outcomes measures include those that would reflect bimodal benefit, such as speech understanding in noise and spatial sound quality perception.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Profound Hearing Loss: Addressing Barriers to Hearing Healthcare
Semin Hear 2018; 39: 428-436
DOI: 10.1055/s-0038-1670708
The impact of profound hearing loss on infants and adults is variable and greatly influenced by improved audition derived from hearing aids and cochlear implants. However, barriers to healthcare, hearing healthcare in particular, can offset the benefits provided by these sensory devices. Common barriers include cost, location, availability of trained professionals, acceptance of the hearing loss, language and cultural differences, secondary disabilities, and mental health issues. These barriers and their distinct presentations vary somewhat by age, language, and where people live (urban vs. rural), and can interfere with receiving testing and devices in a timely manner. They also can limit auditory, speech and language therapies, and interfere with acceptance of the hearing loss and devices. Rehabilitation should focus on eliminating or reducing the adverse impact of these barriers on patients and their families. Some of which can be done through professional training and multidisciplinary activities, counseling, and community outreach.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Self-Assessment Questions
Semin Hear 2018; 39: C1-C8
DOI: 10.1055/s-0038-1673388
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
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Adrenocortical carcinoma presenting as reversible dilated cardiomyopathy
Mansoor C Abdulla
Heart Views 2018 19(2):71-73
We present a 32-year-old woman with no morbidities who was admitted with a dilated cardiomyopathy and cardiac failure due to adrenocortical carcinoma (ACC) which improved completely with surgical resection. Awareness regarding such rare presentations can avoid undue delay in diagnosis and management.
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Heart Views 2018 19(2):71-73
We present a 32-year-old woman with no morbidities who was admitted with a dilated cardiomyopathy and cardiac failure due to adrenocortical carcinoma (ACC) which improved completely with surgical resection. Awareness regarding such rare presentations can avoid undue delay in diagnosis and management.
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Adrenocortical carcinoma presenting as reversible dilated cardiomyopathy
Mansoor C Abdulla
Heart Views 2018 19(2):71-73
We present a 32-year-old woman with no morbidities who was admitted with a dilated cardiomyopathy and cardiac failure due to adrenocortical carcinoma (ACC) which improved completely with surgical resection. Awareness regarding such rare presentations can avoid undue delay in diagnosis and management.
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Heart Views 2018 19(2):71-73
We present a 32-year-old woman with no morbidities who was admitted with a dilated cardiomyopathy and cardiac failure due to adrenocortical carcinoma (ACC) which improved completely with surgical resection. Awareness regarding such rare presentations can avoid undue delay in diagnosis and management.
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Predictors of coronary artery disease progression among high-risk patients with recurrent symptoms
Iyad Farah, Amjad M Ahmed, Raed Odeh, Eltayyeb Alameen, May Al-Khateeb, Elias Fadel, Raid Rabai, Dalia Ali, Bassam Bdeir, Mouaz H Al-Mallah
Heart Views 2018 19(2):45-48
Background: Despite the availability of new potent medical therapies, the rate of progression of angiographic coronary artery disease (CAD) is not well described. The aim of this analysis is to describe the rate and predictors of progression of CAD among patients with recurrent symptoms. Materials and Methods: We reviewed 259 patients (mean age 61 ± 11 years, 70% males) who underwent two coronary angiograms between 2008 and 2013. Progressive CAD was defined as obstructive CAD in a previously disease-free segment or new obstruction in a previously nonobstructive segment. Patients who had coronary artery bypass surgery between these two angiograms were excluded from the analysis. Multivariate logistic regression was used to determine the independent predictors of progression of CAD. Results: The included cohort had a high prevalence of coronary risk factors; hypertension (71%), diabetes (69%), and dyslipidemia (75%). Despite adequate medical therapy, more than half of the patients (61%) had CAD progression. Using multivariate logistic regression, a drop in the left ventricular ejection fraction (LVEF) by more than 5% was the predictor of CAD progression (adjusted odds ratio 5.8, P = 0.042, 95% confidence interval 1.1–31.2). Conclusion: Among high-risk patients with recurrent symptoms, the short-term rate of progression of CAD is high. A drop in LVEF >5% is a predictor of CAD progression. Further studies are needed to determine the prognostic value of CAD progression in the era of potent medical therapy.
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Heart Views 2018 19(2):45-48
Background: Despite the availability of new potent medical therapies, the rate of progression of angiographic coronary artery disease (CAD) is not well described. The aim of this analysis is to describe the rate and predictors of progression of CAD among patients with recurrent symptoms. Materials and Methods: We reviewed 259 patients (mean age 61 ± 11 years, 70% males) who underwent two coronary angiograms between 2008 and 2013. Progressive CAD was defined as obstructive CAD in a previously disease-free segment or new obstruction in a previously nonobstructive segment. Patients who had coronary artery bypass surgery between these two angiograms were excluded from the analysis. Multivariate logistic regression was used to determine the independent predictors of progression of CAD. Results: The included cohort had a high prevalence of coronary risk factors; hypertension (71%), diabetes (69%), and dyslipidemia (75%). Despite adequate medical therapy, more than half of the patients (61%) had CAD progression. Using multivariate logistic regression, a drop in the left ventricular ejection fraction (LVEF) by more than 5% was the predictor of CAD progression (adjusted odds ratio 5.8, P = 0.042, 95% confidence interval 1.1–31.2). Conclusion: Among high-risk patients with recurrent symptoms, the short-term rate of progression of CAD is high. A drop in LVEF >5% is a predictor of CAD progression. Further studies are needed to determine the prognostic value of CAD progression in the era of potent medical therapy.
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Predictors of coronary artery disease progression among high-risk patients with recurrent symptoms
Iyad Farah, Amjad M Ahmed, Raed Odeh, Eltayyeb Alameen, May Al-Khateeb, Elias Fadel, Raid Rabai, Dalia Ali, Bassam Bdeir, Mouaz H Al-Mallah
Heart Views 2018 19(2):45-48
Background: Despite the availability of new potent medical therapies, the rate of progression of angiographic coronary artery disease (CAD) is not well described. The aim of this analysis is to describe the rate and predictors of progression of CAD among patients with recurrent symptoms. Materials and Methods: We reviewed 259 patients (mean age 61 ± 11 years, 70% males) who underwent two coronary angiograms between 2008 and 2013. Progressive CAD was defined as obstructive CAD in a previously disease-free segment or new obstruction in a previously nonobstructive segment. Patients who had coronary artery bypass surgery between these two angiograms were excluded from the analysis. Multivariate logistic regression was used to determine the independent predictors of progression of CAD. Results: The included cohort had a high prevalence of coronary risk factors; hypertension (71%), diabetes (69%), and dyslipidemia (75%). Despite adequate medical therapy, more than half of the patients (61%) had CAD progression. Using multivariate logistic regression, a drop in the left ventricular ejection fraction (LVEF) by more than 5% was the predictor of CAD progression (adjusted odds ratio 5.8, P = 0.042, 95% confidence interval 1.1–31.2). Conclusion: Among high-risk patients with recurrent symptoms, the short-term rate of progression of CAD is high. A drop in LVEF >5% is a predictor of CAD progression. Further studies are needed to determine the prognostic value of CAD progression in the era of potent medical therapy.
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Heart Views 2018 19(2):45-48
Background: Despite the availability of new potent medical therapies, the rate of progression of angiographic coronary artery disease (CAD) is not well described. The aim of this analysis is to describe the rate and predictors of progression of CAD among patients with recurrent symptoms. Materials and Methods: We reviewed 259 patients (mean age 61 ± 11 years, 70% males) who underwent two coronary angiograms between 2008 and 2013. Progressive CAD was defined as obstructive CAD in a previously disease-free segment or new obstruction in a previously nonobstructive segment. Patients who had coronary artery bypass surgery between these two angiograms were excluded from the analysis. Multivariate logistic regression was used to determine the independent predictors of progression of CAD. Results: The included cohort had a high prevalence of coronary risk factors; hypertension (71%), diabetes (69%), and dyslipidemia (75%). Despite adequate medical therapy, more than half of the patients (61%) had CAD progression. Using multivariate logistic regression, a drop in the left ventricular ejection fraction (LVEF) by more than 5% was the predictor of CAD progression (adjusted odds ratio 5.8, P = 0.042, 95% confidence interval 1.1–31.2). Conclusion: Among high-risk patients with recurrent symptoms, the short-term rate of progression of CAD is high. A drop in LVEF >5% is a predictor of CAD progression. Further studies are needed to determine the prognostic value of CAD progression in the era of potent medical therapy.
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Effect of sociodemographic variables and other factors on the usage of different doses of aspirin in postmyocardial infarction patients: A cross-sectional study
Syed Raza Shah, Richard Alweis, Mohammad Yousuf Ul Islam, Maham Khan, Mehwish Hussain, Syed Zawahir Hassan, Aisha Aslam, Waqas Shahnawaz
Heart Views 2018 19(2):49-53
Background: Aspirin (acetylsalicylic acid) is commonly prescribed to patients with a history of myocardial infarction (MI) or occlusive vascular events (e.g., stroke). Due to the complications associated with failure to follow aspirin usage guidelines, determining predictors of aspirin noncompliance in these patient populations is of clinical value and may help prevent poor outcomes. Methods: This cross-sectional study of all patients with a previously diagnosed MI was conducted over a period of 3 months from May 2015 to July 2015 at a government-based hospital in Karachi, Pakistan. Patients were administered a questionnaire that comprised two parts. Part A was designed to measure sociodemographic data including age, gender, and marital status. Part B determined whether the patient was counseled on aspirin significance, and dosage recommendation, and was participating in cardiac rehabilitation therapy. Results: A total of 456 patients included in the study. Of them, 298 (66.7%) were males. The average age was 59 (standard deviation 11) years. The outcome from univariate logistic regression revealed that with 1 year increase of age, the usage of low dose of aspirin was significantly decreased by 2%. Patients with higher education attributed a significantly different effect on the usage of aspirin. Marital status divulged no significant association with the use of different doses of aspirin. The role of rehabilitation had no effect when adjusted for age and level of education. Conclusion: Post-MI patients with higher education level and undergoing rehabilitative therapy are more likely to take low-dose aspirin as compared to those who failed to have these attributes. There is a need for carrying out further work to confirm these findings and expand our recommendations, particularly the sensitive issue regarding adequate doctor counseling among these high-risk patients.
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Heart Views 2018 19(2):49-53
Background: Aspirin (acetylsalicylic acid) is commonly prescribed to patients with a history of myocardial infarction (MI) or occlusive vascular events (e.g., stroke). Due to the complications associated with failure to follow aspirin usage guidelines, determining predictors of aspirin noncompliance in these patient populations is of clinical value and may help prevent poor outcomes. Methods: This cross-sectional study of all patients with a previously diagnosed MI was conducted over a period of 3 months from May 2015 to July 2015 at a government-based hospital in Karachi, Pakistan. Patients were administered a questionnaire that comprised two parts. Part A was designed to measure sociodemographic data including age, gender, and marital status. Part B determined whether the patient was counseled on aspirin significance, and dosage recommendation, and was participating in cardiac rehabilitation therapy. Results: A total of 456 patients included in the study. Of them, 298 (66.7%) were males. The average age was 59 (standard deviation 11) years. The outcome from univariate logistic regression revealed that with 1 year increase of age, the usage of low dose of aspirin was significantly decreased by 2%. Patients with higher education attributed a significantly different effect on the usage of aspirin. Marital status divulged no significant association with the use of different doses of aspirin. The role of rehabilitation had no effect when adjusted for age and level of education. Conclusion: Post-MI patients with higher education level and undergoing rehabilitative therapy are more likely to take low-dose aspirin as compared to those who failed to have these attributes. There is a need for carrying out further work to confirm these findings and expand our recommendations, particularly the sensitive issue regarding adequate doctor counseling among these high-risk patients.
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Effect of sociodemographic variables and other factors on the usage of different doses of aspirin in postmyocardial infarction patients: A cross-sectional study
Syed Raza Shah, Richard Alweis, Mohammad Yousuf Ul Islam, Maham Khan, Mehwish Hussain, Syed Zawahir Hassan, Aisha Aslam, Waqas Shahnawaz
Heart Views 2018 19(2):49-53
Background: Aspirin (acetylsalicylic acid) is commonly prescribed to patients with a history of myocardial infarction (MI) or occlusive vascular events (e.g., stroke). Due to the complications associated with failure to follow aspirin usage guidelines, determining predictors of aspirin noncompliance in these patient populations is of clinical value and may help prevent poor outcomes. Methods: This cross-sectional study of all patients with a previously diagnosed MI was conducted over a period of 3 months from May 2015 to July 2015 at a government-based hospital in Karachi, Pakistan. Patients were administered a questionnaire that comprised two parts. Part A was designed to measure sociodemographic data including age, gender, and marital status. Part B determined whether the patient was counseled on aspirin significance, and dosage recommendation, and was participating in cardiac rehabilitation therapy. Results: A total of 456 patients included in the study. Of them, 298 (66.7%) were males. The average age was 59 (standard deviation 11) years. The outcome from univariate logistic regression revealed that with 1 year increase of age, the usage of low dose of aspirin was significantly decreased by 2%. Patients with higher education attributed a significantly different effect on the usage of aspirin. Marital status divulged no significant association with the use of different doses of aspirin. The role of rehabilitation had no effect when adjusted for age and level of education. Conclusion: Post-MI patients with higher education level and undergoing rehabilitative therapy are more likely to take low-dose aspirin as compared to those who failed to have these attributes. There is a need for carrying out further work to confirm these findings and expand our recommendations, particularly the sensitive issue regarding adequate doctor counseling among these high-risk patients.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qbruWW
Heart Views 2018 19(2):49-53
Background: Aspirin (acetylsalicylic acid) is commonly prescribed to patients with a history of myocardial infarction (MI) or occlusive vascular events (e.g., stroke). Due to the complications associated with failure to follow aspirin usage guidelines, determining predictors of aspirin noncompliance in these patient populations is of clinical value and may help prevent poor outcomes. Methods: This cross-sectional study of all patients with a previously diagnosed MI was conducted over a period of 3 months from May 2015 to July 2015 at a government-based hospital in Karachi, Pakistan. Patients were administered a questionnaire that comprised two parts. Part A was designed to measure sociodemographic data including age, gender, and marital status. Part B determined whether the patient was counseled on aspirin significance, and dosage recommendation, and was participating in cardiac rehabilitation therapy. Results: A total of 456 patients included in the study. Of them, 298 (66.7%) were males. The average age was 59 (standard deviation 11) years. The outcome from univariate logistic regression revealed that with 1 year increase of age, the usage of low dose of aspirin was significantly decreased by 2%. Patients with higher education attributed a significantly different effect on the usage of aspirin. Marital status divulged no significant association with the use of different doses of aspirin. The role of rehabilitation had no effect when adjusted for age and level of education. Conclusion: Post-MI patients with higher education level and undergoing rehabilitative therapy are more likely to take low-dose aspirin as compared to those who failed to have these attributes. There is a need for carrying out further work to confirm these findings and expand our recommendations, particularly the sensitive issue regarding adequate doctor counseling among these high-risk patients.
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Exercise and health
Rachel Hajar
Heart Views 2018 19(2):75-75
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Heart Views 2018 19(2):75-75
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Exercise and health
Rachel Hajar
Heart Views 2018 19(2):75-75
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Heart Views 2018 19(2):75-75
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Clinical significance of elevated high-sensitivity troponin T in low likelihood acute coronary syndrome patients
Mamatha Punjee Rajarao, Abdul Malik Al Kharoosi, Prashanth Panduranga
Heart Views 2018 19(2):54-57
High-sensitivity cardiac troponin T (hs-cTnT) is widely used in Oman and other Gulf countries. The availability of newer generation hs-cTnT has increased the sensitivity of diagnosing non-ST-elevation acute coronary syndrome (ACS). They utilize same antibodies as fourth-generation assay but can measure 10-fold lower levels of cTnT. Any detectable level above the 99th percentile of population suggests myocardial damage. However, the cause could be non-ACS. Therefore, the increase in sensitivity of hs-cTnT assays for ACS comes at the cost of a reduced ACS specificity because more patients with other causes of myocardial injury are detected than with previous cTnT assays. Hence, there is large confusion among emergency physicians regarding optimal cutoff values to definitely confirm non-ST-elevation ACS, especially in patients with low likelihood of ACS. This review summarizes the available clinical and biochemical data to make recommendations about hs-cTnT cutoff values which will guide physicians to take decision in patients presenting with low likelihood ACS.
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Heart Views 2018 19(2):54-57
High-sensitivity cardiac troponin T (hs-cTnT) is widely used in Oman and other Gulf countries. The availability of newer generation hs-cTnT has increased the sensitivity of diagnosing non-ST-elevation acute coronary syndrome (ACS). They utilize same antibodies as fourth-generation assay but can measure 10-fold lower levels of cTnT. Any detectable level above the 99th percentile of population suggests myocardial damage. However, the cause could be non-ACS. Therefore, the increase in sensitivity of hs-cTnT assays for ACS comes at the cost of a reduced ACS specificity because more patients with other causes of myocardial injury are detected than with previous cTnT assays. Hence, there is large confusion among emergency physicians regarding optimal cutoff values to definitely confirm non-ST-elevation ACS, especially in patients with low likelihood of ACS. This review summarizes the available clinical and biochemical data to make recommendations about hs-cTnT cutoff values which will guide physicians to take decision in patients presenting with low likelihood ACS.
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Radial artery pseudoaneurysm following cardiac catheterization: A nonsurgical conservative management approach
Venkatesan Kongunattan, N Ganesh
Heart Views 2018 19(2):67-70
A radial artery pseudoaneurysm represents a rare, potentially catastrophic complication of arterial cannulation that has been reported after cardiac catheterization. Treatment options are limited to chemical, mechanical, and combined approaches to obliterate the radial artery pseudoaneurysm and tract. Manual compression protocols using the TR Band have been variableand anecdotal, without objective measurements of adequate compression, making this technique prone to failure (1). In this report, we present an efficient, safe, and noninvasive management for treatment of radial artery pseudoaneurysms that is cost-effective and efficient and ensures correction without occlusion of the radial artery.
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Heart Views 2018 19(2):67-70
A radial artery pseudoaneurysm represents a rare, potentially catastrophic complication of arterial cannulation that has been reported after cardiac catheterization. Treatment options are limited to chemical, mechanical, and combined approaches to obliterate the radial artery pseudoaneurysm and tract. Manual compression protocols using the TR Band have been variableand anecdotal, without objective measurements of adequate compression, making this technique prone to failure (1). In this report, we present an efficient, safe, and noninvasive management for treatment of radial artery pseudoaneurysms that is cost-effective and efficient and ensures correction without occlusion of the radial artery.
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Radial artery pseudoaneurysm following cardiac catheterization: A nonsurgical conservative management approach
Venkatesan Kongunattan, N Ganesh
Heart Views 2018 19(2):67-70
A radial artery pseudoaneurysm represents a rare, potentially catastrophic complication of arterial cannulation that has been reported after cardiac catheterization. Treatment options are limited to chemical, mechanical, and combined approaches to obliterate the radial artery pseudoaneurysm and tract. Manual compression protocols using the TR Band have been variableand anecdotal, without objective measurements of adequate compression, making this technique prone to failure (1). In this report, we present an efficient, safe, and noninvasive management for treatment of radial artery pseudoaneurysms that is cost-effective and efficient and ensures correction without occlusion of the radial artery.
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Heart Views 2018 19(2):67-70
A radial artery pseudoaneurysm represents a rare, potentially catastrophic complication of arterial cannulation that has been reported after cardiac catheterization. Treatment options are limited to chemical, mechanical, and combined approaches to obliterate the radial artery pseudoaneurysm and tract. Manual compression protocols using the TR Band have been variableand anecdotal, without objective measurements of adequate compression, making this technique prone to failure (1). In this report, we present an efficient, safe, and noninvasive management for treatment of radial artery pseudoaneurysms that is cost-effective and efficient and ensures correction without occlusion of the radial artery.
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Rheumatic mitral stenosis with incidental Wolff–Parkinson–White syndrome: A rare association. Treated by percutaneous transmitral commissurotomy and radiofrequency ablation
Fahad Alkindi, Hossam Abed, Anees Thajudeen, Fathi El-Allus, Salah Arafa
Heart Views 2018 19(2):58-62
The combination of Wolff–Parkinson–White (WPW) syndrome and rheumatic mitral stenosis (MS) is rare in clinical practice. The management of this condition primarily depends on the clinical picture. We describe a 26-year-old male patient with no significant previous medical history and who came for a routine medical assessment before entrance to a police academy service. He was found to have rheumatic MS and WPW.
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Heart Views 2018 19(2):58-62
The combination of Wolff–Parkinson–White (WPW) syndrome and rheumatic mitral stenosis (MS) is rare in clinical practice. The management of this condition primarily depends on the clinical picture. We describe a 26-year-old male patient with no significant previous medical history and who came for a routine medical assessment before entrance to a police academy service. He was found to have rheumatic MS and WPW.
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Heart failure due to massive constrictive calcific pericarditis
Jorge A Brenes-Salazar
Heart Views 2018 19(2):74-74
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Heart Views 2018 19(2):74-74
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Heart failure due to massive constrictive calcific pericarditis
Jorge A Brenes-Salazar
Heart Views 2018 19(2):74-74
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Heart Views 2018 19(2):74-74
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Dissection of ascending aorta: A complication of transradial artery access of coronary procedure
Muhammad Zubair Khan, Luis Guzman, Leila Rezai Gharai, Jose E Exaire
Heart Views 2018 19(2):63-66
Iatrogenic acute dissection of ascending aorta following coronary angiography and percutaneous intervention is a rare complication. Most reports involve localized aortic dissections as a complication of cannulation of a coronary artery with propagation into the ascending aorta. It is usually treated by sealing the intima with a stent in the ostium of the coronary artery or conservative management, while extensive dissections may require a surgical intervention. We describe a case of the subclavian dissection extending into the ascending aorta that occurred during diagnostic catheterization using the radial approach. The patient was successfully treated utilizing conservative management.
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Heart Views 2018 19(2):63-66
Iatrogenic acute dissection of ascending aorta following coronary angiography and percutaneous intervention is a rare complication. Most reports involve localized aortic dissections as a complication of cannulation of a coronary artery with propagation into the ascending aorta. It is usually treated by sealing the intima with a stent in the ostium of the coronary artery or conservative management, while extensive dissections may require a surgical intervention. We describe a case of the subclavian dissection extending into the ascending aorta that occurred during diagnostic catheterization using the radial approach. The patient was successfully treated utilizing conservative management.
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The pulse in medieval and Arab-Islamic medicine: Part 2
Rachel Hajar
Heart Views 2018 19(2):76-80
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Heart Views 2018 19(2):76-80
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Dissection of ascending aorta: A complication of transradial artery access of coronary procedure
Muhammad Zubair Khan, Luis Guzman, Leila Rezai Gharai, Jose E Exaire
Heart Views 2018 19(2):63-66
Iatrogenic acute dissection of ascending aorta following coronary angiography and percutaneous intervention is a rare complication. Most reports involve localized aortic dissections as a complication of cannulation of a coronary artery with propagation into the ascending aorta. It is usually treated by sealing the intima with a stent in the ostium of the coronary artery or conservative management, while extensive dissections may require a surgical intervention. We describe a case of the subclavian dissection extending into the ascending aorta that occurred during diagnostic catheterization using the radial approach. The patient was successfully treated utilizing conservative management.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qcQBIX
Heart Views 2018 19(2):63-66
Iatrogenic acute dissection of ascending aorta following coronary angiography and percutaneous intervention is a rare complication. Most reports involve localized aortic dissections as a complication of cannulation of a coronary artery with propagation into the ascending aorta. It is usually treated by sealing the intima with a stent in the ostium of the coronary artery or conservative management, while extensive dissections may require a surgical intervention. We describe a case of the subclavian dissection extending into the ascending aorta that occurred during diagnostic catheterization using the radial approach. The patient was successfully treated utilizing conservative management.
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The pulse in medieval and Arab-Islamic medicine: Part 2
Rachel Hajar
Heart Views 2018 19(2):76-80
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Heart Views 2018 19(2):76-80
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Dermatologist reveals what ingredients to avoid when choosing Halloween face paint
The US Consumer Product Safety Commission said five percent of Halloween injuries last year were due to allergic reactions and rashes. Dr Alan Levy gives some tips you can follow. (Source: the Mail online | Health)
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Dermatologist reveals what ingredients to avoid when choosing Halloween face paint
The US Consumer Product Safety Commission said five percent of Halloween injuries last year were due to allergic reactions and rashes. Dr Alan Levy gives some tips you can follow. (Source: the Mail online | Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Dermatologist reveals what ingredients to avoid when choosing Halloween face paint
The US Consumer Product Safety Commission said five percent of Halloween injuries last year were due to allergic reactions and rashes. Dr Alan Levy gives some tips you can follow. (Source: the Mail online | Health)
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Lactation Policy and Resources for Trainees in the Department of Radiology
The benefits of breastfeeding are well established for both lactating mothers and their children. Breast milk has been shown to improve infant health outcomes across a number of different measures, including respiratory tract infections, gastrointestinal tract infections, allergies, obesity, and mortality [1], while breastfeeding has been demonstrated to improve health outcomes for mothers, including decreasing the risk for type 2 diabetes and breast and ovarian cancer [1,2]. Given these significant benefits, the American Academy of Pediatrics, World Health Organization, and Institute of Medicine all recommend breastfeeding for 1 year or longer if desired by mother and child [1]. (Source: Journal of the American College of Radiology : JACR)
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Dermatologist reveals what ingredients to avoid when choosing Halloween face paint
The US Consumer Product Safety Commission said five percent of Halloween injuries last year were due to allergic reactions and rashes. Dr Alan Levy gives some tips you can follow. (Source: the Mail online | Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Lactation Policy and Resources for Trainees in the Department of Radiology
The benefits of breastfeeding are well established for both lactating mothers and their children. Breast milk has been shown to improve infant health outcomes across a number of different measures, including respiratory tract infections, gastrointestinal tract infections, allergies, obesity, and mortality [1], while breastfeeding has been demonstrated to improve health outcomes for mothers, including decreasing the risk for type 2 diabetes and breast and ovarian cancer [1,2]. Given these significant benefits, the American Academy of Pediatrics, World Health Organization, and Institute of Medicine all recommend breastfeeding for 1 year or longer if desired by mother and child [1]. (Source: Journal of the American College of Radiology : JACR)
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Disease-modifying therapies alter gut microbial composition in MS
Objective To determine the effects of the disease-modifying therapies, glatiramer acetate (GA) and dimethyl fumarate (DMF), on the gut microbiota in patients with MS. Methods Participants with relapsing MS who were either treatment-naive or treated with GA or DMF were recruited. Peripheral blood mononuclear cells were immunophenotyped. Bacterial DNA was extracted from stool, and amplicons targeting the V4 region of the bacterial/archaeal 16S rRNA gene were sequenced (Illumina MiSeq). Raw reads were clustered into Operational Taxonomic Units using the GreenGenes database. Differential abundance analysis was performed using linear discriminant analysis effect size. Phylogenetic investigation of communities by reconstruction of unobserved states was used to investigate changes to functional ...
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Panax ginseng: A candidate herbal medicine for autoimmune disease
Publication date: Available online 26 October 2018Source: Journal of Ginseng ResearchAuthor(s): Joon-Il Lee, Ik-Hyun ChoAbstractPanax ginseng Meyer (P. ginseng; Korean ginseng) is well known for its medicinal properties. It can alleviate pathological symptoms, promote health, and prevent potential diseases via its anti-inflammatory, anti-oxidant, homeostatic, and other positive effects on biological metabolism. Although many studies have determined effects of P. ginseng on various diseases such as cardiovascular, neurological, and immunological diseases, little is known about the effect of P. ginseng on autoimmune diseases. Here, we review a few reports about effects of P. ginseng on autoimmune diseases (e.g., multiple sclerosis, Crohn's disease, ulcerative colitis, atopic dermatitis, an...
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Disease-modifying therapies alter gut microbial composition in MS
Objective To determine the effects of the disease-modifying therapies, glatiramer acetate (GA) and dimethyl fumarate (DMF), on the gut microbiota in patients with MS. Methods Participants with relapsing MS who were either treatment-naive or treated with GA or DMF were recruited. Peripheral blood mononuclear cells were immunophenotyped. Bacterial DNA was extracted from stool, and amplicons targeting the V4 region of the bacterial/archaeal 16S rRNA gene were sequenced (Illumina MiSeq). Raw reads were clustered into Operational Taxonomic Units using the GreenGenes database. Differential abundance analysis was performed using linear discriminant analysis effect size. Phylogenetic investigation of communities by reconstruction of unobserved states was used to investigate changes to functional ...
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Comparative evaluation of clinical outcomes of laser skin resurfacing using ultrapulse CO2 laser and manual dermabrasion using medium grit drywall sand screen for scar revision in adults – a split scar prospective study
To evaluate the clinical outcomes of laser skin resurfacing using ultrapulse CO2 laser and manual dermabrasion using medium grit drywall sand screen for scar revision in adults with Fitzpatrick Skin type III – V.
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Comparative evaluation of clinical outcomes of laser skin resurfacing using ultrapulse CO2 laser and manual dermabrasion using medium grit drywall sand screen for scar revision in adults – a split scar prospective study
To evaluate the clinical outcomes of laser skin resurfacing using ultrapulse CO2 laser and manual dermabrasion using medium grit drywall sand screen for scar revision in adults with Fitzpatrick Skin type III – V.
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Comparative evaluation of clinical outcomes of laser skin resurfacing using ultrapulse CO2 laser and manual dermabrasion using medium grit drywall sand screen for scar revision in adults – a split scar prospective study
To evaluate the clinical outcomes of laser skin resurfacing using ultrapulse CO2 laser and manual dermabrasion using medium grit drywall sand screen for scar revision in adults with Fitzpatrick Skin type III – V.
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Comparative evaluation of clinical outcomes of laser skin resurfacing using ultrapulse CO2 laser and manual dermabrasion using medium grit drywall sand screen for scar revision in adults – a split scar prospective study
To evaluate the clinical outcomes of laser skin resurfacing using ultrapulse CO2 laser and manual dermabrasion using medium grit drywall sand screen for scar revision in adults with Fitzpatrick Skin type III – V.
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Identification of Factors Related to Cases of Benign Paroxysmal Positional Vertigo Refractory to Canalicular Repositioning Maneuvers and Evaluation of the Need for Magnetic Resonance Imaging in their Management: Retrospective Analysis of a Series of 176 Cases
Int Arch Otorhinolaryngol
DOI: 10.1055/s-0038-1670693
Introduction Benign paroxysmal positional vertigo (BPPV) is the most common form of peripheral vertigo, and, in most cases, it presents a favorable prognosis. The treatment is based on a series of specific canalicular repositioning maneuvers that offer an efficacy close to 100%. Despite this, there are cases that are refractory to treatment, with the persistence of the vertigo symptoms. Objectives The objective of the present paper is to analyze the factors associated with an increased risk of refractory BPPV and the importance of nuclear magnetic resonance in the study of these patients. Methods We retrospectively reviewed the cases of 176 patients diagnosed with BPPV in our center. We divided them into two groups: responders and non-responders to the treatment, and analyzed the possible risk factors associated with a higher risk of refractory vertigo. Fischer exact test was used. Results We found 11 cases refractory to treatment; all of them underwent magnetic resonance imaging (MRI) with gadolinium according to our protocol. Of these, four had an otoneurologic background or pathology, and two other patients presented a multicanal involvement. The difference between the two groups was statistically significant (p < 0.05). Conclusion Otoneurologic background and multicanal involvement were associated with a higher risk of refractory BPPV. When dealing with a BPPV with persistent symptomatology/nystagmus or with early relapse after an initial improvement, other entities that enter into the differential diagnosis must always be considered. We consider it essential to perform an MRI with gadolinium to rule out cases of BPPV that have a central cause.
[...]
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil
Article in Thieme eJournals:
Table of contents | Abstract | open access Full text
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Fish Bone Foreign Body: The Role of Imaging
Int Arch Otorhinolaryngol
DOI: 10.1055/s-0038-1673631
Introduction Fish bone foreign body (FFB) impaction in the upper aerodigestive tract is a common cause for emergency department referral. Its management varies in both diagnosis and treatment paradigms. Fish bone foreign bodies are more commonly found in the oropharynx in cases of patients < 40 years old, and in the esophagus in cases of patients > 40 years old. Symptoms are typically non-indicative for the location of the FFB, with the exception of foreign body sensation at/superior to the cervical esophagus. A lack of findings during the physical examination is routinely followed by imaging, with computed tomography (CT) being the preferred modality. In practice, many patients undergo unnecessary imaging studies, including CT scans. Objectives To identify patients with suspected fish bone impaction who do not require CT imaging and can be safely discharged. Data Synthesis We have searched the PubMed database for the following medical subject headings (MeSH) terms: fish bone, fish foreign body AND oropharynx, hypopharynx, esophagus, flexible esophagoscopy, and rigid esophagoscopy. Our search in the English language yielded 32 papers. Case reports were included, since they highlighted rare and serious complications. Conclusion In patients > 40 years old suspected of fish bone impaction, non-contrast CT is recommended and should be urgently performed, even in the presence of ambiguous symptoms. However, in patients < 40 years old presenting within 24 hours from ingestion, imaging has little diagnostic value due to the low probability of esophageal fish bones. For this specific subgroup, in the absence of clinical findings, discharge without imaging studies may be considered safe.
[...]
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil
Article in Thieme eJournals:
Table of contents | Abstract | open access Full text
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Fish Bone Foreign Body: The Role of Imaging
Int Arch Otorhinolaryngol
DOI: 10.1055/s-0038-1673631
Introduction Fish bone foreign body (FFB) impaction in the upper aerodigestive tract is a common cause for emergency department referral. Its management varies in both diagnosis and treatment paradigms. Fish bone foreign bodies are more commonly found in the oropharynx in cases of patients < 40 years old, and in the esophagus in cases of patients > 40 years old. Symptoms are typically non-indicative for the location of the FFB, with the exception of foreign body sensation at/superior to the cervical esophagus. A lack of findings during the physical examination is routinely followed by imaging, with computed tomography (CT) being the preferred modality. In practice, many patients undergo unnecessary imaging studies, including CT scans. Objectives To identify patients with suspected fish bone impaction who do not require CT imaging and can be safely discharged. Data Synthesis We have searched the PubMed database for the following medical subject headings (MeSH) terms: fish bone, fish foreign body AND oropharynx, hypopharynx, esophagus, flexible esophagoscopy, and rigid esophagoscopy. Our search in the English language yielded 32 papers. Case reports were included, since they highlighted rare and serious complications. Conclusion In patients > 40 years old suspected of fish bone impaction, non-contrast CT is recommended and should be urgently performed, even in the presence of ambiguous symptoms. However, in patients < 40 years old presenting within 24 hours from ingestion, imaging has little diagnostic value due to the low probability of esophageal fish bones. For this specific subgroup, in the absence of clinical findings, discharge without imaging studies may be considered safe.
[...]
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil
Article in Thieme eJournals:
Table of contents | Abstract | open access Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z5M3Ih
Christian Bioethics would like to thank the following guest reviewers for their help during the past year:
David Bradshaw
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Bodies, Agency, and the Relational Self: A Pauline Approach to the Goals and Use of Psychiatric Drugs
Abstract
In this essay, I use the theological anthropology of the apostle Paul as a diagnostic lens in order to bring into focus some implicit assumptions about human personhood in the goals and methods of treatment with psychotropic medications. I argue that Paul views the body as a mode of participation in larger relational matrices in both vulnerable and vital ways. He thus sees the self as constituted relationally rather than as fundamentally isolated and self-determining. Such an understanding of personhood yields an account of human agency as co-constituted and freedom as interpersonally mediated and sustained. From this perspective, the proper goal for psychiatric medication is the removal of barriers to life-giving human connections; methods of care for persons in psychological distress may include medication, but they also require embodied personal encounter.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CIcdUY
That Jagged Little Pill and the Counter-Politics of the Community of the Expelled: Sacramentality and Psychiatric Medications
Abstract
This essay challenges an understandable temptation to view psychiatric pharmacologic interventions as, per se, sacramental. The instinct, I argue, that sacramentality lies at the heart of faithful care for persons with mental illness, is correct, but to locate that sacramentality within the taking of psychiatric medications themselves is to misplace that heart. Rather, Bruce Rogers-Vaughn argues that much of contemporary mental illness is a product of the neoliberal cultural paradigm and correlatively suggests that the primary response must be a counter-politics—a practice of deep solidarity enacted within communities of the expelled. M. Shawn Copeland locates this counter-politics in the dynamic sacramental identity of the Church in a practice she refers to as Eucharistic solidarity. It is this understanding of sacramentality that responds to the etiology and phenomenology Rogers-Vaughn describes and that provides an overarching framework for thinking carefully about the faithful use of psychiatric medications.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qb0jLX
That Jagged Little Pill and the Counter-Politics of the Community of the Expelled: Sacramentality and Psychiatric Medications
Abstract
This essay challenges an understandable temptation to view psychiatric pharmacologic interventions as, per se, sacramental. The instinct, I argue, that sacramentality lies at the heart of faithful care for persons with mental illness, is correct, but to locate that sacramentality within the taking of psychiatric medications themselves is to misplace that heart. Rather, Bruce Rogers-Vaughn argues that much of contemporary mental illness is a product of the neoliberal cultural paradigm and correlatively suggests that the primary response must be a counter-politics—a practice of deep solidarity enacted within communities of the expelled. M. Shawn Copeland locates this counter-politics in the dynamic sacramental identity of the Church in a practice she refers to as Eucharistic solidarity. It is this understanding of sacramentality that responds to the etiology and phenomenology Rogers-Vaughn describes and that provides an overarching framework for thinking carefully about the faithful use of psychiatric medications.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qb0jLX
Christian Bioethics Loses Its Founding Editor
On Monday, June 25, 2018, H. Tristram Engelhardt, Jr., PhD, MD, founder of Christian Bioethics: Non-Ecumenical Studies in Medical Morality, was laid to rest at Holy Archangels Orthodox Christian monastery, set within the beautiful Hill Country of Texas near Comal County. Professor Engelhardt founded Christian Bioethics in 1995. He served as Editor and then Senior Editor from 1995 until 2018. Christian Bioethics thrived for more than two decades through his energy, vision, and dedication. One of the intellectual founders of the fields that would become known as bioethics and the philosophy of medicine, Engelhardt's seminal scholarship has framed philosophical debates surrounding healthcare policy and medical practice throughout the world. Professor Engelhardt's work over the past two decades has focused largely on articulating a traditional Christian bioethics. He made major contributions in advancing our understanding of what bioethics is when it is set within the beliefs, practices, and commitments of the ancient Christian Church. Christian Bioethics mourns his passing.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CFH0Su
Christian Bioethics Loses Its Founding Editor
On Monday, June 25, 2018, H. Tristram Engelhardt, Jr., PhD, MD, founder of Christian Bioethics: Non-Ecumenical Studies in Medical Morality, was laid to rest at Holy Archangels Orthodox Christian monastery, set within the beautiful Hill Country of Texas near Comal County. Professor Engelhardt founded Christian Bioethics in 1995. He served as Editor and then Senior Editor from 1995 until 2018. Christian Bioethics thrived for more than two decades through his energy, vision, and dedication. One of the intellectual founders of the fields that would become known as bioethics and the philosophy of medicine, Engelhardt's seminal scholarship has framed philosophical debates surrounding healthcare policy and medical practice throughout the world. Professor Engelhardt's work over the past two decades has focused largely on articulating a traditional Christian bioethics. He made major contributions in advancing our understanding of what bioethics is when it is set within the beliefs, practices, and commitments of the ancient Christian Church. Christian Bioethics mourns his passing.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CFH0Su
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CFH0Su
Taking Our Meds Faithfully? Christian Engagements with Psychiatric Medication
Abstract
One in seven American adults takes medication to alter or to prevent unwanted experience or behavior. But, the prescription and use of psychiatric medication raises practically important theological and ethical questions for practitioners, for clergy, for scholars, and for people who take medication. How does the prescription and use of psychiatric medication shape imagination and belief about what it means to be human and about the relationship of the body to the acting person? To what extent does medication facilitate technological interpretation and engagement of human life and experience? How does medication use reflect and form modern individualism? How does medication affect human experiences and perceptions of God and of God's action? In this special issue of Christian Bioethics, five scholars from different disciplines—Jeffrey Bishop, M. Therese Lysaught, Warren Kinghorn, Susan Eastman, and John Swinton—engage the meaning of psychiatric medication for Christian bioethics and for faithful Christian practice.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qb0erD
Taking Our Meds Faithfully? Christian Engagements with Psychiatric Medication
Abstract
One in seven American adults takes medication to alter or to prevent unwanted experience or behavior. But, the prescription and use of psychiatric medication raises practically important theological and ethical questions for practitioners, for clergy, for scholars, and for people who take medication. How does the prescription and use of psychiatric medication shape imagination and belief about what it means to be human and about the relationship of the body to the acting person? To what extent does medication facilitate technological interpretation and engagement of human life and experience? How does medication use reflect and form modern individualism? How does medication affect human experiences and perceptions of God and of God's action? In this special issue of Christian Bioethics, five scholars from different disciplines—Jeffrey Bishop, M. Therese Lysaught, Warren Kinghorn, Susan Eastman, and John Swinton—engage the meaning of psychiatric medication for Christian bioethics and for faithful Christian practice.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qb0erD
Christian Bioethics would like to thank the following guest reviewers for their help during the past year:
David Bradshaw
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CL99HA
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CL99HA
“As One Infirm, I Approach the Balm of Life”: Psychiatric Medication, Agency, and Freedom in the Psychology of St. Thomas Aquinas
Abstract
People often take psychiatric medication in order to obtain both freedom from painful experience and freedom for relationships and vocation. Thomas Aquinas' account of agency and freedom offers resources for using medications wisely. For Aquinas, bodily health is only the beginning of freedom. True freedom—always realized imperfectly in this life and perfected only with the assistance of grace—emerges when the acting person consistently pursues life-giving ends and develops habits to act for these ends with ease and pleasure. Psychiatric medications can encourage agency and freedom by correcting pathological processes, by relieving incapacitating suffering, and perhaps by lowering barriers to habituation in virtue, but they can also discourage agency and freedom by inhibiting morally salient emotional responses, by facilitating avoidance of pathological social contexts, and by reinforcing biological determinism. Psychiatric medications must be used only in ways that attend to social context and that encourage the cultivation of healthy agency.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qb05V7
“As One Infirm, I Approach the Balm of Life”: Psychiatric Medication, Agency, and Freedom in the Psychology of St. Thomas Aquinas
Abstract
People often take psychiatric medication in order to obtain both freedom from painful experience and freedom for relationships and vocation. Thomas Aquinas' account of agency and freedom offers resources for using medications wisely. For Aquinas, bodily health is only the beginning of freedom. True freedom—always realized imperfectly in this life and perfected only with the assistance of grace—emerges when the acting person consistently pursues life-giving ends and develops habits to act for these ends with ease and pleasure. Psychiatric medications can encourage agency and freedom by correcting pathological processes, by relieving incapacitating suffering, and perhaps by lowering barriers to habituation in virtue, but they can also discourage agency and freedom by inhibiting morally salient emotional responses, by facilitating avoidance of pathological social contexts, and by reinforcing biological determinism. Psychiatric medications must be used only in ways that attend to social context and that encourage the cultivation of healthy agency.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qb05V7
Of Minds and Brains and Cocreation: Psychopharmaceuticals and Modern Technological Imaginaries
Abstract
Christians are not immune to psychological and psychiatric illness. Yet, Christians should also be careful not to permit popular cultural trends to shape the way that they think about the use of psychiatric treatment with medication. In this essay, I suggest that the tendencies for default usage of psychiatric medication can be problematic for Christians in contemporary culture where a technological imaginary exists. Modern scientific studies of psychiatric medication are partly constructive of how we imagine ourselves. The typical justification for the usage of technology in contemporary culture is the theme of cocreation with God, where Christians see any usage of technology as equivalent to our participating in God's ongoing creative activity. I challenge these ideas in the foregoing paper, noting that the modern technological imaginary that animates modern psychiatry is as constricting as it is enabling. I conclude with a different take on what it might mean for Christians to be cocreators with God.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CHYi19
Of Minds and Brains and Cocreation: Psychopharmaceuticals and Modern Technological Imaginaries
Abstract
Christians are not immune to psychological and psychiatric illness. Yet, Christians should also be careful not to permit popular cultural trends to shape the way that they think about the use of psychiatric treatment with medication. In this essay, I suggest that the tendencies for default usage of psychiatric medication can be problematic for Christians in contemporary culture where a technological imaginary exists. Modern scientific studies of psychiatric medication are partly constructive of how we imagine ourselves. The typical justification for the usage of technology in contemporary culture is the theme of cocreation with God, where Christians see any usage of technology as equivalent to our participating in God's ongoing creative activity. I challenge these ideas in the foregoing paper, noting that the modern technological imaginary that animates modern psychiatry is as constricting as it is enabling. I conclude with a different take on what it might mean for Christians to be cocreators with God.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CHYi19
Medicating the Soul: Why Medication Needs Stories
Abstract
This paper explores and develops a theological perspective on taking and receiving medication. It argues that the task of prescribing and administering psychopharmaceutical drugs is a thoroughly theological enterprise and should be looked at and practiced accordingly. The paper presents a theological anthropology that opens up space for rethinking the role of medication not only in relation to therapeutic intervention, but in relation to the chief end of human beings: to glorify God and live with God forever. Drawing on theology and the narratives of people living with mental health challenges, the paper seeks to facilitate a movement from neurons to souls: a movement that realigns the goals of prescribing and opens up space to rethink the nature of "symptoms" and the ultimate intentions of the psychopharmacological enterprise.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qcKaph
Ara h 1 and Ara h 6 Sensitization Causes Clinical Peanut Allergy in Ara h 2-Negative Individuals
Conclusions: Half of the peanut-sensitized individuals in Iceland were not sensitized to the major allergen Ara h 2. Ara h 1, Ara h 3, and Ara h 6 sensitizations resulted in a positive open peanut challenge and they are therefore clinically important for individuals with a peanut allergy in Iceland.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3t4DT
IgE Cross-Reactivity of Cashew Nut Allergens
Conclusions: Results demonstrate the in vitro presence of IgE cross-sensitisation in children towards multiple Anacardiaceae species. In this study, putative novel allergens were identified in cashew, pistachio, and pink peppercorn, which may pose factors that underlie the observed cross-sensitivity to these species. The clinical relevance of this widespread cross-sensitisation is unknown.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
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CBCT assessment of gubernacular canals in relation to eruption disturbance and pathologic condition associated with impacted/unerupted teeth
The aim of this study was to demonstrate the imaging characteristics of gubernacular canals (GCs) in impacted/unerupted permanent teeth and to determine whether these characteristics differ as a result of the presence of eruption disturbances or pathologic conditions associated with impacted/unerupted teeth.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SkxN7k
Ara h 1 and Ara h 6 Sensitization Causes Clinical Peanut Allergy in Ara h 2-Negative Individuals
Conclusions: Half of the peanut-sensitized individuals in Iceland were not sensitized to the major allergen Ara h 2. Ara h 1, Ara h 3, and Ara h 6 sensitizations resulted in a positive open peanut challenge and they are therefore clinically important for individuals with a peanut allergy in Iceland.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3t4DT
IgE Cross-Reactivity of Cashew Nut Allergens
Conclusions: Results demonstrate the in vitro presence of IgE cross-sensitisation in children towards multiple Anacardiaceae species. In this study, putative novel allergens were identified in cashew, pistachio, and pink peppercorn, which may pose factors that underlie the observed cross-sensitivity to these species. The clinical relevance of this widespread cross-sensitisation is unknown.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yAoqbs
CBCT assessment of gubernacular canals in relation to eruption disturbance and pathologic condition associated with impacted/unerupted teeth
The aim of this study was to demonstrate the imaging characteristics of gubernacular canals (GCs) in impacted/unerupted permanent teeth and to determine whether these characteristics differ as a result of the presence of eruption disturbances or pathologic conditions associated with impacted/unerupted teeth.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SkxN7k
Advances in mechanisms of allergic disease in 2017
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells, TH2 lymphocytes, B cells, dendritic cells, microbiome and barrier function, eosinophils, and mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (TH2) and type 2 innate lymphoid effector cells. New pathways of lymphocyte activation, trafficking, and recruitment and effector cell mechanisms have been discovered. (Source: Journal of Allergy and Clinical Immunology)
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Advances in mechanisms of allergic disease in 2017
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells, TH2 lymphocytes, B cells, dendritic cells, microbiome and barrier function, eosinophils, and mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (TH2) and type 2 innate lymphoid effector cells. New pathways of lymphocyte activation, trafficking, and recruitment and effector cell mechanisms have been discovered. (Source: Journal of Allergy and Clinical Immunology)
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AIF-1 and RNASET2 Play Complementary Roles in the Innate Immune Response of Medicinal Leech
Recent studies demonstrated that allograft inflammatory factor-1 (AIF-1) and RNASET2 act as chemoattractants for macrophages and modulate the inflammatory processes in both vertebrates and invertebrates. The expression of these proteins significantly increases after bacterial infection; however, the mechanisms by which they regulate the innate immune response are still poorly defined. Here, we evaluate the effect of bacterial lipopolysaccharide injection on the expression pattern of these genes and the interrelation between them during innate immune response in the medicinal leech, an invertebrate model with a simple anatomy and a marked similarity with vertebrates in inflammatory processes. Collectively, prokaryotic-eukaryotic co-cultures and in vivo infection assays suggest that RNASET2 ...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Oe9WmQ
AIF-1 and RNASET2 Play Complementary Roles in the Innate Immune Response of Medicinal Leech
Recent studies demonstrated that allograft inflammatory factor-1 (AIF-1) and RNASET2 act as chemoattractants for macrophages and modulate the inflammatory processes in both vertebrates and invertebrates. The expression of these proteins significantly increases after bacterial infection; however, the mechanisms by which they regulate the innate immune response are still poorly defined. Here, we evaluate the effect of bacterial lipopolysaccharide injection on the expression pattern of these genes and the interrelation between them during innate immune response in the medicinal leech, an invertebrate model with a simple anatomy and a marked similarity with vertebrates in inflammatory processes. Collectively, prokaryotic-eukaryotic co-cultures and in vivo infection assays suggest that RNASET2 ...
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Differentiating acute food protein-induced enterocolitis syndrome from its mimics: a comparison of clinical features and routine laboratory biomarkers
ConclusionsIn the young vomiting child, lethargy, floppiness, pallor without fever and normal CRP should alert clinicians to a possible diagnosis of FPIES. In contrast a highly elevated CRP is not a feature of FPIES, and in such cases an alternative diagnosis must be considered. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Differentiating acute food protein-induced enterocolitis syndrome from its mimics: a comparison of clinical features and routine laboratory biomarkers
ConclusionsIn the young vomiting child, lethargy, floppiness, pallor without fever and normal CRP should alert clinicians to a possible diagnosis of FPIES. In contrast a highly elevated CRP is not a feature of FPIES, and in such cases an alternative diagnosis must be considered. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yAj5kG
Ara h 1 and Ara h 6 Sensitization Causes Clinical Peanut Allergy in Ara h 2-Negative Individuals
Conclusions: Half of the peanut-sensitized individuals in Iceland were not sensitized to the major allergen Ara h 2. Ara h 1, Ara h 3, and Ara h 6 sensitizations resulted in a positive open peanut challenge and they are therefore clinically important for individuals with a peanut allergy in Iceland.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3t4DT
Ara h 1 and Ara h 6 Sensitization Causes Clinical Peanut Allergy in Ara h 2-Negative Individuals
Conclusions: Half of the peanut-sensitized individuals in Iceland were not sensitized to the major allergen Ara h 2. Ara h 1, Ara h 3, and Ara h 6 sensitizations resulted in a positive open peanut challenge and they are therefore clinically important for individuals with a peanut allergy in Iceland.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O3t4DT
IgE Cross-Reactivity of Cashew Nut Allergens
Conclusions: Results demonstrate the in vitro presence of IgE cross-sensitisation in children towards multiple Anacardiaceae species. In this study, putative novel allergens were identified in cashew, pistachio, and pink peppercorn, which may pose factors that underlie the observed cross-sensitivity to these species. The clinical relevance of this widespread cross-sensitisation is unknown.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yAoqbs
Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients
The inability to resolve Coccidioides infection correlates with elevated Treg frequency and functional marker expression at diagnosis. Treg frequency may be a diagnostic for calibrating treatment aggressiveness for patients likely to develop chronic cocciodiomycosis.
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The 2018 Nobel Prize in Physiology or Medicine: An exemplar of Bench to Bedside in Immunology
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The 2018 Nobel Prize in Physiology or Medicine: An exemplar of Bench to Bedside in Immunology
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Validation of a novel method for localization of parathyroid adenomas using SPECT/CT
Accurate localization of parathyroid adenomas is of critical importance in surgical planning for minimally invasive parathyroidectomy. SPECT/CT is considered the investigation of choice but has limitations reg...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yDknv8
Bone-Cancer Assessment and Destruction Pattern Analysis in Long-Bone X -ray Image
Abstract
Bone cancer originates from bone and rapidly spreads to the rest of the body affecting the patient. A quick and preliminary diagnosis of bone cancer begins with the analysis of bone X-ray or MRI image. Compared to MRI, an X-ray image provides a low-cost diagnostic tool for diagnosis and visualization of bone cancer. In this paper, a novel technique for the assessment of cancer stage and grade in long bones based on X-ray image analysis has been proposed. Cancer-affected bone images usually appear with a variation in bone texture in the affected region. A fusion of different methodologies is used for the purpose of our analysis. In the proposed approach, we extract certain features from bone X-ray images and use support vector machine (SVM) to discriminate healthy and cancerous bones. A technique based on digital geometry is deployed for localizing cancer-affected regions. Characterization of the present stage and grade of the disease and identification of the underlying bone-destruction pattern are performed using a decision tree classifier. Furthermore, the method leads to the development of a computer-aided diagnostic tool that can readily be used by paramedics and doctors. Experimental results on a number of test cases reveal satisfactory diagnostic inferences when compared with ground truth known from clinical findings.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JgTdy9
Validation of a novel method for localization of parathyroid adenomas using SPECT/CT
Accurate localization of parathyroid adenomas is of critical importance in surgical planning for minimally invasive parathyroidectomy. SPECT/CT is considered the investigation of choice but has limitations reg...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yDknv8
Bone-Cancer Assessment and Destruction Pattern Analysis in Long-Bone X -ray Image
Abstract
Bone cancer originates from bone and rapidly spreads to the rest of the body affecting the patient. A quick and preliminary diagnosis of bone cancer begins with the analysis of bone X-ray or MRI image. Compared to MRI, an X-ray image provides a low-cost diagnostic tool for diagnosis and visualization of bone cancer. In this paper, a novel technique for the assessment of cancer stage and grade in long bones based on X-ray image analysis has been proposed. Cancer-affected bone images usually appear with a variation in bone texture in the affected region. A fusion of different methodologies is used for the purpose of our analysis. In the proposed approach, we extract certain features from bone X-ray images and use support vector machine (SVM) to discriminate healthy and cancerous bones. A technique based on digital geometry is deployed for localizing cancer-affected regions. Characterization of the present stage and grade of the disease and identification of the underlying bone-destruction pattern are performed using a decision tree classifier. Furthermore, the method leads to the development of a computer-aided diagnostic tool that can readily be used by paramedics and doctors. Experimental results on a number of test cases reveal satisfactory diagnostic inferences when compared with ground truth known from clinical findings.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JgTdy9
Variability of efavirenz plasma concentrations among pediatric HIV patients treated with efavirenz based combination antiretroviral therapy in Dar es Salaam, Tanzania.
CONCLUSION: Wide inter-individual variability in efavirenz plasma concentrations is seen among Tanzanian children in routine clinical practice with many being outside the recommended therapeutic range. Virologic failure is very high in children with sub-therapeutic levels. Concentrations outside the therapeutic window suggest the need for dose adjustment on the basis of therapeutic drug monitoring to optimize treatment. PMID: 30352627 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OPozSC
Variability of efavirenz plasma concentrations among pediatric HIV patients treated with efavirenz based combination antiretroviral therapy in Dar es Salaam, Tanzania.
CONCLUSION: Wide inter-individual variability in efavirenz plasma concentrations is seen among Tanzanian children in routine clinical practice with many being outside the recommended therapeutic range. Virologic failure is very high in children with sub-therapeutic levels. Concentrations outside the therapeutic window suggest the need for dose adjustment on the basis of therapeutic drug monitoring to optimize treatment. PMID: 30352627 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
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In vitro and In vivo Effects of Tribulus terrestris on Some Immunological Parameters, Lymphocyte Proliferation, and DNA Integrity in Sheep
In conclusion, TTE could modulate the immune functions and induce lymphocyte transformation in rams. (Source: Small Ruminant Research)
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In vitro and In vivo Effects of Tribulus terrestris on Some Immunological Parameters, Lymphocyte Proliferation, and DNA Integrity in Sheep
In conclusion, TTE could modulate the immune functions and induce lymphocyte transformation in rams. (Source: Small Ruminant Research)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RfwnK0
Editorial Board
Publication date: October 2018Source: Veterinary Immunology and Immunopathology, Volume 204Author(s): (Source: Veterinary Immunology and Immunopathology)
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Endometrial transcripts of proinflammatory cytokine and enzymes in prostaglandin synthesis are upregulated in the bitches with atrophic pyometra
Publication date: Available online 25 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Laishram Kipjen Singh, Manas Kumar Patra, Girish Kumar Mishra, Vidya Singh, Vikramaditya Upmanyu, Abhishek C. Saxena, Sanjay Kumar Singh, Goutam Kumar Das, Harendra Kumar, Narayanan KrishnaswamyAbstractInflammatory markers of endometrial origin are valuable in order to differentiate the pyometra from cystic endometrial hyperplasia in the bitch. In the present study, we hypothesized that histological categorization would distinguish the differential regulation of the proinflammatory genes in the endometrium of bitches with pyometra. Ovariohysterectomy was done on bitches with confirmatory diagnosis of pyometra (n = 18). Using endometrium to myometrium ratio of 0.79 as threshold,...
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Treatment of allergic rhinitis reduces acute asthma exacerbation risk among asthmatic children aged 2-18 years
ConclusionThe preschool patients had a higher incidence of AE than the older patients in general. Adequate treatment with INCS and/or SGH in asthma with AR patients is important for reducing the incidence of AE of asthma. (Source: Journal of Microbiology, Immunology and Infection)
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Surgical treatment of non-tuberculous mycobacterial lymphadenitis in children: Our experience and a narrative review.
Authors: Torretta S, Gaffuri M, Ibba T, Capaccio P, Marchisio P, Maruca A, Bosis S, Pignataro L Abstract Non-tuberculous mycobacterial lymphadenitis (NTML) accounts for about 95% of the cases of head-and-neck mycobacterial lymphadenitis, and its prevalence has been increasing in the Western world. The diagnostic work-up can be challenging, and differential diagnoses such as tuberculous and suppurative lymphadenitis need to be considered. It may, therefore, not be diagnosed until the disease is in a late stage, by which time it becomes locally destructive and is characterized by a chronically discharging sinus. The treatment options include a medical approach, a wait-and-see policy, and surgery, with the last being considered the treatment of choice despite the high risk of iatrogen...
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Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3 β-dependent pathway.
In this study, the neuroprotective effects of taurine against ACR-induced neurotoxicity and the potential underlying mechanisms were explored. Rats were intoxicated with ACR and injected with taurine in different groups for totally 2 weeks between January and July 2017. Electron microscopic analysis was used to observe the changes in tissues of the rats. Meanwhile, the levels of proteins including p-Akt, p-GSK3β, SIM312, and MBP were detected by Western blot. Furthermore, the GSK3β phosphorylation in taurine-treated dorsal root ganglion (DRG) with ACR was examined in the presence of the Akt inhibitor, MK-2206. The analysis of behavioral performances and electron micrographs indicated that taurine treatment significantly attenuated the toxic manifestations induced by ACR and stimulated ...
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Molecules, Vol. 23, Pages 2778: Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea
Authors: Michele Catanzaro Emanuela Corsini Michela Rosini Marco Racchi Cristina Lanni The immune system is an efficient integrated network of cellular elements and chemicals developed to preserve the integrity of the organism against external insults and its correct functioning and balance are essential to avoid the occurrence of a great variety of disorders. To date, evidence from literature highlights an increase in immunological diseases and a great attention has been focused on the development of molecules able to modulate the immune response. There is an enormous global demand for new effective therapies and researchers are investigating new fields. One promising strategy is the use of herbal medicines as integrative, complementary and preventive therapy. The active com...
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Molecules, Vol. 23, Pages 2776: Anti-Inflammatory Activities of Pentaherbs formula and Its Influence on Gut Microbiota in Allergic Asthma
This study sheds light on the anti-inflammatory activities of PHF on allergic asthma. It also provides novel in vivo evidence that herbal medicines can ameliorate symptoms of allergic diseases may potentially prevent the development of subsequent atopic disorder such as allergic asthma through the influence of the gut microbiota. (Source: Molecules)
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CD16a with oligomannose-type N-glycans is the only “low-affinity” Fc {gamma} receptor that binds the IgG crystallizable fragment with high affinity in vitro [Immunology]
Fc γ receptors (FcγRs) bind circulating IgG (IgG1) at the surface of leukocytes. Antibodies clustered at the surface of a targeted particle trigger a protective immune response through activating FcγRs. Three recent reports indicate that the composition of the asparagine-linked carbohydrate chains (N-glycans) of FcγRIIIa/CD16a impacted IgG1-binding affinity. Here we determined how N-glycan composition affected the affinity of the "low-affinity" FcγRs for six homogeneous IgG1 Fc N-glycoforms (G0, G0F, G2, G2F, A2G2, and A2G2F). Surprisingly, CD16a with oligomannose N-glycans bound to IgG1 Fc (A2G2) with a KD = 1.0 ± 0.1 nm. This affinity represents a 51-fold increase over the affinity measured for CD16a with complex-type N-glycans (51 ± 8 nm) and is comparable with the affinity o...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yBmm2V
Endometrial transcripts of proinflammatory cytokine and enzymes in prostaglandin synthesis are upregulated in the bitches with atrophic pyometra
Publication date: Available online 25 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Laishram Kipjen Singh, Manas Kumar Patra, Girish Kumar Mishra, Vidya Singh, Vikramaditya Upmanyu, Abhishek C. Saxena, Sanjay Kumar Singh, Goutam Kumar Das, Harendra Kumar, Narayanan KrishnaswamyAbstractInflammatory markers of endometrial origin are valuable in order to differentiate the pyometra from cystic endometrial hyperplasia in the bitch. In the present study, we hypothesized that histological categorization would distinguish the differential regulation of the proinflammatory genes in the endometrium of bitches with pyometra. Ovariohysterectomy was done on bitches with confirmatory diagnosis of pyometra (n = 18). Using endometrium to myometrium ratio of 0.79 as threshold,...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yD3lNI
Treatment of allergic rhinitis reduces acute asthma exacerbation risk among asthmatic children aged 2-18 years
ConclusionThe preschool patients had a higher incidence of AE than the older patients in general. Adequate treatment with INCS and/or SGH in asthma with AR patients is important for reducing the incidence of AE of asthma. (Source: Journal of Microbiology, Immunology and Infection)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O8JXNf
Surgical treatment of non-tuberculous mycobacterial lymphadenitis in children: Our experience and a narrative review.
Authors: Torretta S, Gaffuri M, Ibba T, Capaccio P, Marchisio P, Maruca A, Bosis S, Pignataro L Abstract Non-tuberculous mycobacterial lymphadenitis (NTML) accounts for about 95% of the cases of head-and-neck mycobacterial lymphadenitis, and its prevalence has been increasing in the Western world. The diagnostic work-up can be challenging, and differential diagnoses such as tuberculous and suppurative lymphadenitis need to be considered. It may, therefore, not be diagnosed until the disease is in a late stage, by which time it becomes locally destructive and is characterized by a chronically discharging sinus. The treatment options include a medical approach, a wait-and-see policy, and surgery, with the last being considered the treatment of choice despite the high risk of iatrogen...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yzemPR
Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3 β-dependent pathway.
In this study, the neuroprotective effects of taurine against ACR-induced neurotoxicity and the potential underlying mechanisms were explored. Rats were intoxicated with ACR and injected with taurine in different groups for totally 2 weeks between January and July 2017. Electron microscopic analysis was used to observe the changes in tissues of the rats. Meanwhile, the levels of proteins including p-Akt, p-GSK3β, SIM312, and MBP were detected by Western blot. Furthermore, the GSK3β phosphorylation in taurine-treated dorsal root ganglion (DRG) with ACR was examined in the presence of the Akt inhibitor, MK-2206. The analysis of behavioral performances and electron micrographs indicated that taurine treatment significantly attenuated the toxic manifestations induced by ACR and stimulated ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ob6edw
Molecules, Vol. 23, Pages 2778: Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea
Authors: Michele Catanzaro Emanuela Corsini Michela Rosini Marco Racchi Cristina Lanni The immune system is an efficient integrated network of cellular elements and chemicals developed to preserve the integrity of the organism against external insults and its correct functioning and balance are essential to avoid the occurrence of a great variety of disorders. To date, evidence from literature highlights an increase in immunological diseases and a great attention has been focused on the development of molecules able to modulate the immune response. There is an enormous global demand for new effective therapies and researchers are investigating new fields. One promising strategy is the use of herbal medicines as integrative, complementary and preventive therapy. The active com...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yCN0IP
Molecules, Vol. 23, Pages 2776: Anti-Inflammatory Activities of Pentaherbs formula and Its Influence on Gut Microbiota in Allergic Asthma
This study sheds light on the anti-inflammatory activities of PHF on allergic asthma. It also provides novel in vivo evidence that herbal medicines can ameliorate symptoms of allergic diseases may potentially prevent the development of subsequent atopic disorder such as allergic asthma through the influence of the gut microbiota. (Source: Molecules)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O9EJRz
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