Late Lower Cranial Neuropathy in Oropharyngeal Cancer Patients

Late Lower Cranial Neuropathy in Oropharyngeal Cancer Patients  Cancer NetworkFull coverage

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Automated ASPECT rating: comparison between the Frontier ASPECT Score software and the Brainomix software

Abstract

Purpose

Computer-aided diagnosis (CAD) appears promising in early ischemic change detection computed tomography (CT). This study aimed to compare the performance of two new CAD systems (Frontier ASPECTS Prototype and Brainomix) with two experienced readers in selected patients with suspected acute ischemic stroke.

Methods

Retrospectively, non-contrast brain CTs of 150 patients suspected for acute middle cerebral artery ischemia were analyzed with respect to ASPECTS first separately, than in consensus by two senior radiologists, and by use of Frontier and Brainomix. Besides the fully automatic Frontier and Brainomix readings (Frontier_1, Brainomix_1), readings adjusted for the affected brain side (known by CT angiography or clinical presentation, Frontier_2, Brainomix_2) were assessed. Statistical analysis was performed by intraclass correlation and Bland-Altman statistics.

Results

The score-based ASPECTS readings of Brainomix_1, Brainomix_2, both radiologists, and the expert consensus reading correlated highly (r = 0.714 to 0.841; always p < 0.001), whereas Frontier_1 and Frontier_2 correlated only lowly or moderately with both radiologists, the expert consensus reading, and Brainomix (r = 0.471 to 0.680; always p < 0.001). Bland-Altman analysis revealed lower mean ASPECT difference and standard deviation of difference for Brainomix_2 (mean difference = −0.2; SD = 1.15) compared to Frontier_2 (mean difference = 1.2; SD = 1.76). Correlation of region-based ASPECTS reading with the expert consensus reading was moderate for Brainomix_2 (r = 0.534), but only low for Frontier_2 (r = 0283; always p < 0.001).

Conclusion

We found high agreement in ASPECTS rating between both radiologists, expert consensus reading, and Brainomix, but only low to moderate agreement to Frontier.

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Automated ASPECT rating: comparison between the Frontier ASPECT Score software and the Brainomix software

Abstract

Purpose

Computer-aided diagnosis (CAD) appears promising in early ischemic change detection computed tomography (CT). This study aimed to compare the performance of two new CAD systems (Frontier ASPECTS Prototype and Brainomix) with two experienced readers in selected patients with suspected acute ischemic stroke.

Methods

Retrospectively, non-contrast brain CTs of 150 patients suspected for acute middle cerebral artery ischemia were analyzed with respect to ASPECTS first separately, than in consensus by two senior radiologists, and by use of Frontier and Brainomix. Besides the fully automatic Frontier and Brainomix readings (Frontier_1, Brainomix_1), readings adjusted for the affected brain side (known by CT angiography or clinical presentation, Frontier_2, Brainomix_2) were assessed. Statistical analysis was performed by intraclass correlation and Bland-Altman statistics.

Results

The score-based ASPECTS readings of Brainomix_1, Brainomix_2, both radiologists, and the expert consensus reading correlated highly (r = 0.714 to 0.841; always p < 0.001), whereas Frontier_1 and Frontier_2 correlated only lowly or moderately with both radiologists, the expert consensus reading, and Brainomix (r = 0.471 to 0.680; always p < 0.001). Bland-Altman analysis revealed lower mean ASPECT difference and standard deviation of difference for Brainomix_2 (mean difference = −0.2; SD = 1.15) compared to Frontier_2 (mean difference = 1.2; SD = 1.76). Correlation of region-based ASPECTS reading with the expert consensus reading was moderate for Brainomix_2 (r = 0.534), but only low for Frontier_2 (r = 0283; always p < 0.001).

Conclusion

We found high agreement in ASPECTS rating between both radiologists, expert consensus reading, and Brainomix, but only low to moderate agreement to Frontier.

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Allergy to Surgical Implants

Abstract

Surgical implants are essential elements of repair procedures to correct worn out joints, damaged spinal components, heart and vascular disease, and chronic pain. However, many of the materials that provide stability, flexibility, and durability to the implants are also immunogenic. Fortunately, allergic responses to surgical implants are infrequent. When they do occur, however, the associated pain, swelling, inflammation, and decreased range of motion can significantly impair the implant function. Given the high numbers of joint replacements performed in the developed world, allergic reactions to orthopedic implants form the largest category of allergic responses. The most important allergens in this category include nickel, cobalt, chromium, and bone cement. These allergens are also the most important in reactions to spinal surgeries. Multiple cardiac and neurostimulatory devices are constructed of metals and adhesives that can be sensitizing in some individuals. Implantable pulse generators, important in cardiac pacemakers, gastric stimulators, and neurostimulators, may include components made of stainless steel, titanium alloy, platinum and iridium, epoxy resins, poly methyl methacrylates, and isocyanates, all of which are immunogenic in some patients. Cardiac stents and patches are often made of Nitinol, a composite of nickel and titanium. More surgical procedures are closed using skin glues, which are also capable of triggering a blistering contact dermatitis. Patch testing is the gold standard to determine sensitization, and this review provides a list of standard allergens to test for different implants. The patients most appropriate for testing include (1) pre-operative joint replacement patients with a prior history of skin reactions to metal jewelry, jean snaps, watch bands, metal glass frames, artificial nails, or skin glue; (2) post-operative joint replacement failure patients needing revision without an obvious cause such as infection or mechanical incompatibility; and (3) post-operative cardiac or neurological patients with localized rash, pain, swelling, or inflammation near or over the implant.

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Allergy to Surgical Implants

Abstract

Surgical implants are essential elements of repair procedures to correct worn out joints, damaged spinal components, heart and vascular disease, and chronic pain. However, many of the materials that provide stability, flexibility, and durability to the implants are also immunogenic. Fortunately, allergic responses to surgical implants are infrequent. When they do occur, however, the associated pain, swelling, inflammation, and decreased range of motion can significantly impair the implant function. Given the high numbers of joint replacements performed in the developed world, allergic reactions to orthopedic implants form the largest category of allergic responses. The most important allergens in this category include nickel, cobalt, chromium, and bone cement. These allergens are also the most important in reactions to spinal surgeries. Multiple cardiac and neurostimulatory devices are constructed of metals and adhesives that can be sensitizing in some individuals. Implantable pulse generators, important in cardiac pacemakers, gastric stimulators, and neurostimulators, may include components made of stainless steel, titanium alloy, platinum and iridium, epoxy resins, poly methyl methacrylates, and isocyanates, all of which are immunogenic in some patients. Cardiac stents and patches are often made of Nitinol, a composite of nickel and titanium. More surgical procedures are closed using skin glues, which are also capable of triggering a blistering contact dermatitis. Patch testing is the gold standard to determine sensitization, and this review provides a list of standard allergens to test for different implants. The patients most appropriate for testing include (1) pre-operative joint replacement patients with a prior history of skin reactions to metal jewelry, jean snaps, watch bands, metal glass frames, artificial nails, or skin glue; (2) post-operative joint replacement failure patients needing revision without an obvious cause such as infection or mechanical incompatibility; and (3) post-operative cardiac or neurological patients with localized rash, pain, swelling, or inflammation near or over the implant.

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Rectal Microbicide Acceptability, Tolerability and Adherence

Condition:   HIV Prevention Interventions:   Behavioral: Placebo rectal insert;   Behavioral: Placebo rectal suppository;   Behavioral: Placebo rectal douche Sponsors:   Microbicide Trials Network;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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The PEBBLES Study - Testing a Strategy for Preventing Eczema and Food Allergy in High Risk Infants

Conditions:   Eczema;   Asthma;   Allergy;Food Intervention:   Drug: EpiCeram Sponsor:   University of Melbourne Recruiting (Source: ClinicalTrials.gov)

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Patient Portal - Flu Reminder Recall

Conditions:   Influenza;   Respiratory Tract Infections;   Vaccines Interventions:   Behavioral: 1 MyChart R/R;   Behavioral: 2 MyChart R/R;   Behavioral: 3 MyChart R/R Sponsors:   University of California, Los Angeles;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Study Evaluating the Efficacy and Safety of Fexofenadine in Subjects Suffering From Seasonal Allergic Rhinitis in Presence of Pollutants

Condition:   Rhinitis Seasonal Interventions:   Drug: Fexofenadine M016455;   Drug: Placebo Sponsor:   Sanofi Not yet recruiting (Source: ClinicalTrials.gov)

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Serum Immunologic Markers Levels in During the Delivery

Condition:   Immunologic Markers Intervention:   Diagnostic Test: Blood sampling Sponsor:   Brno University Hospital Not yet recruiting (Source: ClinicalTrials.gov)

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COMISS Score for Detection of Cow's Milk Protein Allergy in Children With Recrrent or Persistent Gastrointestinal Manifistations in Infants Attending Assuit University Children Hospital - Egypt

Condition:   Cow Milk Allergy Intervention:   Diagnostic Test: COMISS score Sponsor:   caroline maher Not yet recruiting (Source: ClinicalTrials.gov)

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Growth of Infants With Cow's Milk Allergy Fed an Amino Acid-based Formula Containing Two Human Milk Oligosaccharides

Condition:   Cow Milk Allergy Intervention:   Other: Food for Specific Medical Purpose Sponsor:   Nestlé Not yet recruiting (Source: ClinicalTrials.gov)

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A Methodology Development Environmental Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis

Condition:   Allergic Conjunctivitis Interventions:   Drug: Reproxalap Ophthalmic Solution (0.25%);   Drug: Reproxalap Ophthalmic Solution (0.5%);   Drug: Vehicle Ophthalmic Solution Sponsor:   Aldeyra Therapeutics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)

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Rectal Microbicide Acceptability, Tolerability and Adherence

Condition:   HIV Prevention Interventions:   Behavioral: Placebo rectal insert;   Behavioral: Placebo rectal suppository;   Behavioral: Placebo rectal douche Sponsors:   Microbicide Trials Network;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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The PEBBLES Study - Testing a Strategy for Preventing Eczema and Food Allergy in High Risk Infants

Conditions:   Eczema;   Asthma;   Allergy;Food Intervention:   Drug: EpiCeram Sponsor:   University of Melbourne Recruiting (Source: ClinicalTrials.gov)

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Patient Portal - Flu Reminder Recall

Conditions:   Influenza;   Respiratory Tract Infections;   Vaccines Interventions:   Behavioral: 1 MyChart R/R;   Behavioral: 2 MyChart R/R;   Behavioral: 3 MyChart R/R Sponsors:   University of California, Los Angeles;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Study Evaluating the Efficacy and Safety of Fexofenadine in Subjects Suffering From Seasonal Allergic Rhinitis in Presence of Pollutants

Condition:   Rhinitis Seasonal Interventions:   Drug: Fexofenadine M016455;   Drug: Placebo Sponsor:   Sanofi Not yet recruiting (Source: ClinicalTrials.gov)

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COMISS Score for Detection of Cow's Milk Protein Allergy in Children With Recrrent or Persistent Gastrointestinal Manifistations in Infants Attending Assuit University Children Hospital - Egypt

Condition:   Cow Milk Allergy Intervention:   Diagnostic Test: COMISS score Sponsor:   caroline maher Not yet recruiting (Source: ClinicalTrials.gov)

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Growth of Infants With Cow's Milk Allergy Fed an Amino Acid-based Formula Containing Two Human Milk Oligosaccharides

Condition:   Cow Milk Allergy Intervention:   Other: Food for Specific Medical Purpose Sponsor:   Nestlé Not yet recruiting (Source: ClinicalTrials.gov)

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A Methodology Development Environmental Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis

Condition:   Allergic Conjunctivitis Interventions:   Drug: Reproxalap Ophthalmic Solution (0.25%);   Drug: Reproxalap Ophthalmic Solution (0.5%);   Drug: Vehicle Ophthalmic Solution Sponsor:   Aldeyra Therapeutics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)

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Audiovestibular Symptoms in Systemic Autoimmune Diseases.

Authors: Ralli M, D'Aguanno V, Di Stadio A, De Virgilio A, Croce A, Longo L, Greco A, de Vincentiis M Abstract Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and au...

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Hearing Aid Use and Auditory Verbal Therapy Improve Voice Quality of Deaf Children

Adequate phonation is self-regulated by auditory feedback. Children with bilateral profound hearing loss (PHL) lack this feedback resulting in abnormal voice. Adequate hearing aid use and auditory-verbal therapy (AVT) may improve voice quality in deaf children. (Source: Journal of Voice)

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Gender Differences in Improvement of Older-Person-Specific Quality of Life after Hearing-Aid Fitting

Age-related hearing loss is the third most common reason for disability in the world and has a significant impact on quality of life (QoL) amongst older adults. (Source: Disability and Health Journal)

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Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis

The aim of this systematic review was to determine whether bromelain is an effective drug for the control of pain and inflammation associated with third molar surgery. Randomized, controlled clinical trials on the subject were identified through a systematic search of the literature using the PubMed/MEDLINE, Scopus, and Cochrane Library databases. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Two independent, blinded reviewers selected studies based on the inclusion criteria. (Source: International Journal of Oral and Maxillofacial Surgery)

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Audiovestibular Symptoms in Systemic Autoimmune Diseases.

Authors: Ralli M, D'Aguanno V, Di Stadio A, De Virgilio A, Croce A, Longo L, Greco A, de Vincentiis M Abstract Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and au...

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Hearing Aid Use and Auditory Verbal Therapy Improve Voice Quality of Deaf Children

Adequate phonation is self-regulated by auditory feedback. Children with bilateral profound hearing loss (PHL) lack this feedback resulting in abnormal voice. Adequate hearing aid use and auditory-verbal therapy (AVT) may improve voice quality in deaf children. (Source: Journal of Voice)

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Gender Differences in Improvement of Older-Person-Specific Quality of Life after Hearing-Aid Fitting

Age-related hearing loss is the third most common reason for disability in the world and has a significant impact on quality of life (QoL) amongst older adults. (Source: Disability and Health Journal)

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Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis

The aim of this systematic review was to determine whether bromelain is an effective drug for the control of pain and inflammation associated with third molar surgery. Randomized, controlled clinical trials on the subject were identified through a systematic search of the literature using the PubMed/MEDLINE, Scopus, and Cochrane Library databases. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Two independent, blinded reviewers selected studies based on the inclusion criteria. (Source: International Journal of Oral and Maxillofacial Surgery)

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Allergy to Surgical Implants

Abstract

Surgical implants are essential elements of repair procedures to correct worn out joints, damaged spinal components, heart and vascular disease, and chronic pain. However, many of the materials that provide stability, flexibility, and durability to the implants are also immunogenic. Fortunately, allergic responses to surgical implants are infrequent. When they do occur, however, the associated pain, swelling, inflammation, and decreased range of motion can significantly impair the implant function. Given the high numbers of joint replacements performed in the developed world, allergic reactions to orthopedic implants form the largest category of allergic responses. The most important allergens in this category include nickel, cobalt, chromium, and bone cement. These allergens are also the most important in reactions to spinal surgeries. Multiple cardiac and neurostimulatory devices are constructed of metals and adhesives that can be sensitizing in some individuals. Implantable pulse generators, important in cardiac pacemakers, gastric stimulators, and neurostimulators, may include components made of stainless steel, titanium alloy, platinum and iridium, epoxy resins, poly methyl methacrylates, and isocyanates, all of which are immunogenic in some patients. Cardiac stents and patches are often made of Nitinol, a composite of nickel and titanium. More surgical procedures are closed using skin glues, which are also capable of triggering a blistering contact dermatitis. Patch testing is the gold standard to determine sensitization, and this review provides a list of standard allergens to test for different implants. The patients most appropriate for testing include (1) pre-operative joint replacement patients with a prior history of skin reactions to metal jewelry, jean snaps, watch bands, metal glass frames, artificial nails, or skin glue; (2) post-operative joint replacement failure patients needing revision without an obvious cause such as infection or mechanical incompatibility; and (3) post-operative cardiac or neurological patients with localized rash, pain, swelling, or inflammation near or over the implant.

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Allergy to Surgical Implants

Abstract

Surgical implants are essential elements of repair procedures to correct worn out joints, damaged spinal components, heart and vascular disease, and chronic pain. However, many of the materials that provide stability, flexibility, and durability to the implants are also immunogenic. Fortunately, allergic responses to surgical implants are infrequent. When they do occur, however, the associated pain, swelling, inflammation, and decreased range of motion can significantly impair the implant function. Given the high numbers of joint replacements performed in the developed world, allergic reactions to orthopedic implants form the largest category of allergic responses. The most important allergens in this category include nickel, cobalt, chromium, and bone cement. These allergens are also the most important in reactions to spinal surgeries. Multiple cardiac and neurostimulatory devices are constructed of metals and adhesives that can be sensitizing in some individuals. Implantable pulse generators, important in cardiac pacemakers, gastric stimulators, and neurostimulators, may include components made of stainless steel, titanium alloy, platinum and iridium, epoxy resins, poly methyl methacrylates, and isocyanates, all of which are immunogenic in some patients. Cardiac stents and patches are often made of Nitinol, a composite of nickel and titanium. More surgical procedures are closed using skin glues, which are also capable of triggering a blistering contact dermatitis. Patch testing is the gold standard to determine sensitization, and this review provides a list of standard allergens to test for different implants. The patients most appropriate for testing include (1) pre-operative joint replacement patients with a prior history of skin reactions to metal jewelry, jean snaps, watch bands, metal glass frames, artificial nails, or skin glue; (2) post-operative joint replacement failure patients needing revision without an obvious cause such as infection or mechanical incompatibility; and (3) post-operative cardiac or neurological patients with localized rash, pain, swelling, or inflammation near or over the implant.

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Scientists map interactions between head and neck cancer and HPV virus

Scientists map interactions between head and neck cancer and HPV virus  Science DailyScientists Plot Communication Between Head And Neck Cancer And HPV Virus  FMR Blog (blog)Bad news for men with two lovers  News MailFull coverage

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Scientists map interactions between head and neck cancer and HPV virus

Scientists map interactions between head and neck cancer and HPV virus  Science DailyScientists Plot Communication Between Head And Neck Cancer And HPV Virus  FMR Blog (blog)Bad news for men with two lovers  News MailFull coverage

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Audiovestibular Symptoms in Systemic Autoimmune Diseases.

Authors: Ralli M, D'Aguanno V, Di Stadio A, De Virgilio A, Croce A, Longo L, Greco A, de Vincentiis M Abstract Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and au...

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The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.

Authors: Zhao X, Hua M, Yan S, Yu J, Han F, Zhong C, Wang R, Zhang C, Hou M, Ma D Abstract The pathogenesis of multiple myeloma (MM) remains unclear and the NLRP3 inflammasome has been more and more recognized in the progression of many diseases. To investigate the role of the NLRP3 inflammasome in MM, we determined the genetic polymorphisms and expression of NLRP3 inflammasome-related genes (IL-1β, IL-18, CARD8, and NF-κB) in MM patients, and explored their clinical relevance. Furthermore, we investigated the relationship of the NLRP3 inflammasome with Th cells in MM. Our study showed that the CARD8-C10X (rs2043211) AT genotype contributed to the susceptibility of MM. CARD8-C10X TT patients had earlier clinical stage. The WBC count in the three CARD8 genotypes showed an increasi...

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Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding.

Authors: Glueck B, Han Y, Cresci GAM Abstract Excessive ethanol consumption causes adverse effects and contributes to organ dysfunction. Ethanol metabolism triggers oxidative stress, altered immune function, and gut dysbiosis. The gut microbiome is known to contribute to the maintenance of intestinal homeostasis, and disturbances are associated with pathology. A consequence of gut dysbiosis is also alterations in its metabolic and fermentation byproducts. The gut microbiota ferments undigested dietary polysaccharides to yield short-chain fatty acids, predominantly acetate, propionate, and butyrate. Butyrate has many biological mechanisms of action including anti-inflammatory and immunoprotective effects, and its depletion is associated with intestinal injury. We previously showed t...

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Interspecies chimeric livers: A step closer to solving the problem of transplantable organ shortage?

'History of medicine tells us that procedures that were inconceivable yesterday, barely achievable today often become the routine of tomorrow'.1 When Dr. Thomas E. Starzl made this remarkable statement in 1982, he knew the medical, surgical, immunological, and even political challenges to perfor ming a liver transplantation. In the 1980s, liver transplantation was a barely achievable procedure. In 2018, we are living in Dr. Starzl's tomorrow, where the liver transplantation is a daily routine, not only in Europe2 or the United States. (Source: Journal of Hepatology)

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Pro ‐inflammatory role of transient receptor potential canonical channel 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps

International Forum of Allergy&Rhinology, EarlyView. (Source: International Forum of Allergy and Rhinology)

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Asthma phenotypes based on health services utilization for allergic diseases in a province-wide birth cohort

Previous studies on asthma phenotypes were often conducted in selected clinical populations and overlooked changes over the life course. (Source: Annals of Allergy, Asthma and Immunology)

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Dendritic cells cross ‐talk with tumour antigen‐specific CD8+ T cells, Vγ9γδT cells and Vα24NKT cells in patients with glioblastoma multiforme and in healthy donors

Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)

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Diagnosis and Management of NSAID ‐Exacerbated Respiratory Disease (N‐ERD) – a EAACI position paper

Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)

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Audiovestibular Symptoms in Systemic Autoimmune Diseases.

Authors: Ralli M, D'Aguanno V, Di Stadio A, De Virgilio A, Croce A, Longo L, Greco A, de Vincentiis M Abstract Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and au...

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The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.

Authors: Zhao X, Hua M, Yan S, Yu J, Han F, Zhong C, Wang R, Zhang C, Hou M, Ma D Abstract The pathogenesis of multiple myeloma (MM) remains unclear and the NLRP3 inflammasome has been more and more recognized in the progression of many diseases. To investigate the role of the NLRP3 inflammasome in MM, we determined the genetic polymorphisms and expression of NLRP3 inflammasome-related genes (IL-1β, IL-18, CARD8, and NF-κB) in MM patients, and explored their clinical relevance. Furthermore, we investigated the relationship of the NLRP3 inflammasome with Th cells in MM. Our study showed that the CARD8-C10X (rs2043211) AT genotype contributed to the susceptibility of MM. CARD8-C10X TT patients had earlier clinical stage. The WBC count in the three CARD8 genotypes showed an increasi...

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Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding.

Authors: Glueck B, Han Y, Cresci GAM Abstract Excessive ethanol consumption causes adverse effects and contributes to organ dysfunction. Ethanol metabolism triggers oxidative stress, altered immune function, and gut dysbiosis. The gut microbiome is known to contribute to the maintenance of intestinal homeostasis, and disturbances are associated with pathology. A consequence of gut dysbiosis is also alterations in its metabolic and fermentation byproducts. The gut microbiota ferments undigested dietary polysaccharides to yield short-chain fatty acids, predominantly acetate, propionate, and butyrate. Butyrate has many biological mechanisms of action including anti-inflammatory and immunoprotective effects, and its depletion is associated with intestinal injury. We previously showed t...

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Interspecies chimeric livers: A step closer to solving the problem of transplantable organ shortage?

'History of medicine tells us that procedures that were inconceivable yesterday, barely achievable today often become the routine of tomorrow'.1 When Dr. Thomas E. Starzl made this remarkable statement in 1982, he knew the medical, surgical, immunological, and even political challenges to perfor ming a liver transplantation. In the 1980s, liver transplantation was a barely achievable procedure. In 2018, we are living in Dr. Starzl's tomorrow, where the liver transplantation is a daily routine, not only in Europe2 or the United States. (Source: Journal of Hepatology)

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Dendritic cells cross ‐talk with tumour antigen‐specific CD8+ T cells, Vγ9γδT cells and Vα24NKT cells in patients with glioblastoma multiforme and in healthy donors

Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)

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Diagnosis and Management of NSAID ‐Exacerbated Respiratory Disease (N‐ERD) – a EAACI position paper

Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)

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Prevalence of anti-aquaporin 4 antibody in a diagnostic cohort of patients being investigated for possible neuromyelitis optica spectrum disorder in Western Australia

To evaluate the prevalence of anti-AQP4 antibody in serum and CSF samples from patients being investigated for possible neuromyelitis optica spectrum disorder (NMOSD) referred to the PathWest State reference laboratory using a sensitive cell-based assay (CBA). (Source: Journal of Neuroimmunology)

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Comparison of a new Skin Prick Test (SPT) Tape with the conventional SPT

The Skin Prick Test Tape delivered bio-equivalent results to the conventional skin prick test for the diagnosis of mite allergen sensitization, offering an easy and standardized application procedure, avoiding cross-contamination and guaranteeing sterility. (Source: Journal of Allergy and Clinical Immunology)

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Next generation anti-S. aureus vaccines: a potential new therapeutic option for atopic dermatitis?

(Source: Journal of Allergy and Clinical Immunology)

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Hematopoietic Stem Cell Transplantation for Activated PI3K δ Syndrome: Who, When and How?

(Source: Journal of Allergy and Clinical Immunology)

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Next generation anti-S. aureus vaccines: a potential new therapeutic option for atopic dermatitis?

(Source: Journal of Allergy and Clinical Immunology)

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Hematopoietic Stem Cell Transplantation for Activated PI3K δ Syndrome: Who, When and How?

(Source: Journal of Allergy and Clinical Immunology)

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Global Head And Neck Cancer Drugs Therapeutics Market 2018 | Industry Key Players, Type, Applications, world's ...

Global Head And Neck Cancer Drugs Therapeutics Market 2018 | Industry Key Players, Type, Applications, world's ...  firstpharmacist.comHead And Neck Cancer Treatment Market Analysis, Size, Share, Key Player, Trends and Forecast to 2021  Our Market ResearchFull coverage

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Global Head And Neck Cancer Drugs Therapeutics Market 2018 | Industry Key Players, Type, Applications, world's ...

Global Head And Neck Cancer Drugs Therapeutics Market 2018 | Industry Key Players, Type, Applications, world's ...  firstpharmacist.comHead And Neck Cancer Treatment Market Analysis, Size, Share, Key Player, Trends and Forecast to 2021  Our Market ResearchFull coverage

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Assessing whether EORTC QLQ-30 and FACT-G measure the same constructs of quality of life in patients with total laryngectomy

The European Organization for Research and Treatment of Cancer QOL Core Questionnaire 30 (EORTC QLQ-30) and the Assessment of Cancer Therapy-General (FACT-G) are the two most widely used measures of cancer-spe...

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Physical activity, cardiovascular health, quality of life and blood pressure control in hypertensive subjects: randomized clinical trial

Physical activity (PA) promotes cardiovascular health and health related quality of life (HRQoL), although the effect of that on blood pressure (BP) control has rarely been studied in hypertensive subjects. Ou...

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Quality of life in persons with dementia using regional dementia care network services in Germany: a one-year follow-up study

The majority of individuals with dementia live in the community; thus, regional dementia care networks are becoming increasingly more important for the provision of care. To date, four different types of demen...

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Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) adapted for use in adult patients: report from an initial validation study

Localized scleroderma (LoS) affects both children and adults and is associated with permanent functional and cosmetic impairment, and reduced quality of life predominating in adults. The Localized Scleroderma ...

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Assessing whether EORTC QLQ-30 and FACT-G measure the same constructs of quality of life in patients with total laryngectomy

The European Organization for Research and Treatment of Cancer QOL Core Questionnaire 30 (EORTC QLQ-30) and the Assessment of Cancer Therapy-General (FACT-G) are the two most widely used measures of cancer-spe...

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Physical activity, cardiovascular health, quality of life and blood pressure control in hypertensive subjects: randomized clinical trial

Physical activity (PA) promotes cardiovascular health and health related quality of life (HRQoL), although the effect of that on blood pressure (BP) control has rarely been studied in hypertensive subjects. Ou...

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The interpretation of change score of the pain disability index after vocational rehabilitation is baseline dependent

The Pain Disability Index (PDI) is a widely-used instrument to measure pain-related disability. The aim of this study was to assess the responsiveness and interpretation of change score of the PDI in patients ...

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Quality of life in persons with dementia using regional dementia care network services in Germany: a one-year follow-up study

The majority of individuals with dementia live in the community; thus, regional dementia care networks are becoming increasingly more important for the provision of care. To date, four different types of demen...

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Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) adapted for use in adult patients: report from an initial validation study

Localized scleroderma (LoS) affects both children and adults and is associated with permanent functional and cosmetic impairment, and reduced quality of life predominating in adults. The Localized Scleroderma ...

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Audiology Faculty Author Impact Metrics as a Function of Institution

Conclusion These institutional metrics may be used to serve as a benchmark for institutional production, attracting students, hiring faculty, and assessing allocation of institutional funding. (Source: American Journal of Audiology)

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Tinnitus Suppression in Cochlear Implant Patients Using a Sound Therapy App

Conclusion The results suggest that the use of tinnitus therapy sounds delivered through a CI can be acceptable and provides relief for some tinnitus sufferers. (Source: American Journal of Audiology)

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Evaluating Hearing Aid Management: Development of the Hearing Aid Skills and Knowledge Inventory (HASKI)

Conclusions The Hearing Aid Skills and Knowledge Inventories are valid and reliable measures of hearing aid handling and management skills with good potential for use in clinical settings. Hearing aid management is an area of difficulty for the majority of hearing aid owners, indicating the need for clinicians to improve the efficacy of hearing aid management training delivered. (Source: American Journal of Audiology)

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Assessment of Subjective Visual Vertical (SVV) Using the “Bucket Test” and the Virtual SVV System

Conclusions The Virtual system is a more reliable measure of static SVV than the bucket test. Therefore, the Virtual system could be utilized as a screening device for utricular dysfunction in busy clinical settings. (Source: American Journal of Audiology)

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Author Response to Peck (2018), “Questionable Use of ‘Nonorganic’ in ‘Estimating Nonorganic Hearing Thresholds’”

Conclusions We prefer the term "nonorganic" rather than the term "false and exaggerated hearing loss." "Nonorganic," in our view, is a nonjudgmental term and, as stated byAusten and Lynch (2004), implies "as little as possible about its cause" (p. 450). (Source: American Journal of Audiology)

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Does Contralateral Inhibition of Transient Evoked Otoacoustic Emissions Suggest Sex or Ear Laterality Effects?

Conclusions If one considers that efferent inhibition of TEOAEs is an absolute quantity, the significant effect of ear and sex on normalized inhibition and the negative association and linear predictive relationship between TEOAE level and inhibition can be viewed as spurious effects. As such, contralateral inhibition of TEOAEs does not suggest sex or ear laterality effects. (Source: American Journal of Audiology)

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Negative Association of Hepatitis B Virus With Hearing Impairment

Conclusions Contrary to previous reports, subjects who are HBsAg positive had a lower prevalence of hearing impairment compared with subjects who are HBsAg negative. Further studies are warranted to investigate the underlying mechanism regarding their negative relationship. (Source: American Journal of Audiology)

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The Role of Audiologists in Assuring Follow-Up to Outpatient Screening in Early Hearing Detection and Intervention Systems

Conclusions The findings were used to identify quality improvement strategies to decrease the loss to follow-up. Strategies included ensuring audiology support, providing information in the parent's native language, educating personnel in the newborn intensive care units, developing and disseminating information in Spanish in written form, and educating hospitals on the importance of scheduling the outpatient rescreening before hospital discharge. (Source: American Journal of Audiology)

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Could the Use of Acoustic Reflexes Prior to Administering Distortion Product Otoacoustic Emissions (DPOAEs) Affect the Results of DPOAEs?

Conclusions The use of a protocol when using an automated system that includes both acoustic reflexes and distortion product otoacoustic emissions is important. Overall, presentation of acoustic reflexes prior to measuring distortion product otoacoustic emission did not affect distortion product otoacoustic emission results; therefore, test sequence can be modified as needed. (Source: American Journal of Audiology)

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Effects of Different Electrode Configurations on the Narrow Band Level-Specific CE-Chirp and Tone-Burst Auditory Brainstem Response at Multiple Intensity Levels and Frequencies in Subjects With Normal Hearing

Conclusion Both the ipsilateral and vertical montages can be used to record ABR to the NB LS CE-Chirp because of the small enhancement in the wave V amplitude provided by the vertical montage. (Source: American Journal of Audiology)

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Questionable Use of “Nonorganic” in Norrix et al. (2017), “Estimating Nonorganic Hearing Thresholds”

Conclusion"False" hearing loss is a more appropriate term than "nonorganic" hearing loss. (Source: American Journal of Audiology)

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Auditory Outcomes in Patients Who Received Proton Radiotherapy for Craniopharyngioma

Conclusion At a median follow-up time of 2 years post-PRT, normal hearing was maintained within the CF range. However, subclinical decreases in hearing were observed, particularly in the EHF range and in the DPOAE level; thus, long-term follow-up is recommended to monitor for potential auditory late effects from PRT. (Source: American Journal of Audiology)

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Audiology Faculty Author Impact Metrics as a Function of Institution

Conclusion These institutional metrics may be used to serve as a benchmark for institutional production, attracting students, hiring faculty, and assessing allocation of institutional funding. (Source: American Journal of Audiology)

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Tinnitus Suppression in Cochlear Implant Patients Using a Sound Therapy App

Conclusion The results suggest that the use of tinnitus therapy sounds delivered through a CI can be acceptable and provides relief for some tinnitus sufferers. (Source: American Journal of Audiology)

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Evaluating Hearing Aid Management: Development of the Hearing Aid Skills and Knowledge Inventory (HASKI)

Conclusions The Hearing Aid Skills and Knowledge Inventories are valid and reliable measures of hearing aid handling and management skills with good potential for use in clinical settings. Hearing aid management is an area of difficulty for the majority of hearing aid owners, indicating the need for clinicians to improve the efficacy of hearing aid management training delivered. (Source: American Journal of Audiology)

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Assessment of Subjective Visual Vertical (SVV) Using the “Bucket Test” and the Virtual SVV System

Conclusions The Virtual system is a more reliable measure of static SVV than the bucket test. Therefore, the Virtual system could be utilized as a screening device for utricular dysfunction in busy clinical settings. (Source: American Journal of Audiology)

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Author Response to Peck (2018), “Questionable Use of ‘Nonorganic’ in ‘Estimating Nonorganic Hearing Thresholds’”

Conclusions We prefer the term "nonorganic" rather than the term "false and exaggerated hearing loss." "Nonorganic," in our view, is a nonjudgmental term and, as stated byAusten and Lynch (2004), implies "as little as possible about its cause" (p. 450). (Source: American Journal of Audiology)

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Does Contralateral Inhibition of Transient Evoked Otoacoustic Emissions Suggest Sex or Ear Laterality Effects?

Conclusions If one considers that efferent inhibition of TEOAEs is an absolute quantity, the significant effect of ear and sex on normalized inhibition and the negative association and linear predictive relationship between TEOAE level and inhibition can be viewed as spurious effects. As such, contralateral inhibition of TEOAEs does not suggest sex or ear laterality effects. (Source: American Journal of Audiology)

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Negative Association of Hepatitis B Virus With Hearing Impairment

Conclusions Contrary to previous reports, subjects who are HBsAg positive had a lower prevalence of hearing impairment compared with subjects who are HBsAg negative. Further studies are warranted to investigate the underlying mechanism regarding their negative relationship. (Source: American Journal of Audiology)

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The Role of Audiologists in Assuring Follow-Up to Outpatient Screening in Early Hearing Detection and Intervention Systems

Conclusions The findings were used to identify quality improvement strategies to decrease the loss to follow-up. Strategies included ensuring audiology support, providing information in the parent's native language, educating personnel in the newborn intensive care units, developing and disseminating information in Spanish in written form, and educating hospitals on the importance of scheduling the outpatient rescreening before hospital discharge. (Source: American Journal of Audiology)

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Could the Use of Acoustic Reflexes Prior to Administering Distortion Product Otoacoustic Emissions (DPOAEs) Affect the Results of DPOAEs?

Conclusions The use of a protocol when using an automated system that includes both acoustic reflexes and distortion product otoacoustic emissions is important. Overall, presentation of acoustic reflexes prior to measuring distortion product otoacoustic emission did not affect distortion product otoacoustic emission results; therefore, test sequence can be modified as needed. (Source: American Journal of Audiology)

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Effects of Different Electrode Configurations on the Narrow Band Level-Specific CE-Chirp and Tone-Burst Auditory Brainstem Response at Multiple Intensity Levels and Frequencies in Subjects With Normal Hearing

Conclusion Both the ipsilateral and vertical montages can be used to record ABR to the NB LS CE-Chirp because of the small enhancement in the wave V amplitude provided by the vertical montage. (Source: American Journal of Audiology)

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Questionable Use of “Nonorganic” in Norrix et al. (2017), “Estimating Nonorganic Hearing Thresholds”

Conclusion"False" hearing loss is a more appropriate term than "nonorganic" hearing loss. (Source: American Journal of Audiology)

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Auditory Outcomes in Patients Who Received Proton Radiotherapy for Craniopharyngioma

Conclusion At a median follow-up time of 2 years post-PRT, normal hearing was maintained within the CF range. However, subclinical decreases in hearing were observed, particularly in the EHF range and in the DPOAE level; thus, long-term follow-up is recommended to monitor for potential auditory late effects from PRT. (Source: American Journal of Audiology)

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Masthead

(Source: American Journal of Audiology)

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Letter to the Editor about the article published in Clinical Oral Investigations tilted “Impacted and transmigrated mandibular canines: an analysis of 3D radiographic imaging data” (Bertl MH, Frey C, Bertl K, Giannis K, Gahleitner A, Strbac GD (2018), Clin Oral Investig , doi: 10.1007/s00784-018-2342-0)

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Cancer centre to soon launch in-patient, home care services

Cancer centre to soon launch in-patient, home care services  The Hindu24-hour in-patient wing at Cochin Cancer Centre soon  Deccan ChronicleFull coverage

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Letter to the Editor about the article published in Clinical Oral Investigations tilted “Impacted and transmigrated mandibular canines: an analysis of 3D radiographic imaging data” (Bertl MH, Frey C, Bertl K, Giannis K, Gahleitner A, Strbac GD (2018), Clin Oral Investig , doi: 10.1007/s00784-018-2342-0)

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Cancer centre to soon launch in-patient, home care services

Cancer centre to soon launch in-patient, home care services  The Hindu24-hour in-patient wing at Cochin Cancer Centre soon  Deccan ChronicleFull coverage

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Halloween gala set to benefit cancer survivors

Halloween gala set to benefit cancer survivors  MassLive.comFull coverage

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Eosinophilic Esophagitis - Pathophysiology and its Clinical Implications.

Authors: Inage E, Furuta GT, Menard-Katcher C, Masterson JC Abstract Eosinophilic Esophagitis is an antigen mediated chronic disease that is distinct from gastroesophageal reflux disease. EoE an emerging clinical problem that is rapidly growing in incidence and in recognition. It is characterized clinically by feeding dysfunction, dysphagia and reflux-like symptoms. Histologically EoE is identifiable by a dense epithelial eosinophilic infiltrate. Experimental modeling and clinical studies over the last decade have greatly improved our understanding of this disease and led to improvements in clinical understanding and the assessment of therapeutic options for patients and their clinicians who manage this disease. In this review we review the cliniopathologic diagnostic criteria and ...

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Halloween gala set to benefit cancer survivors

Halloween gala set to benefit cancer survivors  MassLive.comFull coverage

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Eosinophilic Esophagitis - Pathophysiology and its Clinical Implications.

Authors: Inage E, Furuta GT, Menard-Katcher C, Masterson JC Abstract Eosinophilic Esophagitis is an antigen mediated chronic disease that is distinct from gastroesophageal reflux disease. EoE an emerging clinical problem that is rapidly growing in incidence and in recognition. It is characterized clinically by feeding dysfunction, dysphagia and reflux-like symptoms. Histologically EoE is identifiable by a dense epithelial eosinophilic infiltrate. Experimental modeling and clinical studies over the last decade have greatly improved our understanding of this disease and led to improvements in clinical understanding and the assessment of therapeutic options for patients and their clinicians who manage this disease. In this review we review the cliniopathologic diagnostic criteria and ...

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Tongue-in-Groove Technique for Rhinoplasty: Technical Refinements and Considerations

Facial plast Surg
DOI: 10.1055/s-0038-1670647

A key concept in successful rhinoplasty surgery is maintaining or increasing tip support, and addressing tip projection and rotation. The tongue-in-groove (TIG) technique is a method to achieve this goal using sutures to create a strong connection between the septum and medial crura to change tip rotation and projection. Criticisms of this method include that it may cause stiffness of the nasal tip and columellar retraction. TIG is routinely used by the authors during anterior septal reconstructions (a modified extracorporeal septoplasty technique), as well as in primary and revision aesthetic and functional rhinoplasties. Through this review, technical aspects of the TIG technique are discussed, as well as how pitfalls of the technique can be avoided, as illustrated by several rhinoplasty patient examples.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Tongue-in-Groove Technique for Rhinoplasty: Technical Refinements and Considerations

Facial plast Surg
DOI: 10.1055/s-0038-1670647

A key concept in successful rhinoplasty surgery is maintaining or increasing tip support, and addressing tip projection and rotation. The tongue-in-groove (TIG) technique is a method to achieve this goal using sutures to create a strong connection between the septum and medial crura to change tip rotation and projection. Criticisms of this method include that it may cause stiffness of the nasal tip and columellar retraction. TIG is routinely used by the authors during anterior septal reconstructions (a modified extracorporeal septoplasty technique), as well as in primary and revision aesthetic and functional rhinoplasties. Through this review, technical aspects of the TIG technique are discussed, as well as how pitfalls of the technique can be avoided, as illustrated by several rhinoplasty patient examples.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Medical News Today: What to know about chicken allergies

While fish and seafood often cause allergies, chicken meat allergies are less common. The symptoms can vary from mild to very severe. In some cases, chicken allergies are related to bird egg allergies, though they can also exist separately. Chicken allergies may be linked to other bird allergies. Learn more here. (Source: Health News from Medical News Today)

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Medical News Today: What to know about chicken allergies

While fish and seafood often cause allergies, chicken meat allergies are less common. The symptoms can vary from mild to very severe. In some cases, chicken allergies are related to bird egg allergies, though they can also exist separately. Chicken allergies may be linked to other bird allergies. Learn more here. (Source: Health News from Medical News Today)

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Coexistence of oral lichen planus and pemphigus vulgaris

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Clinical, double blind, randomized controlled trial of experimental adhesive protocols in caries-affected dentin

Abstract

Objective

To evaluate the clinical performance of posterior resin composite restorations regarding experimental and regular adhesive protocols in caries affected-dentin (CAD).

Material and methods

A total of 92 class I and class II cavities with carious lesions were selected and randomly assigned to the following groups: (1) bioactive glass-ceramic powder/two-step etch and rinse system, (2) control/two-step etch and rinse system, (3) bioactive glass-ceramic powder/two-step self-etching system, and (4) control/two-step self-etching system. Two operators carried out the adhesive protocols and restored the cavities with a nano-hybrid resin composite. Participants were followed up at 1 week and 6, 12, and 18 months for clinical evaluation performed by two blinded examiners and calibrated according to FDI criteria. Data were analyzed using Kruskal-Wallis and Dunn tests with a confidence of 95%.

Results

The clinical performance of resin composite restoration was not affected by the experimental use of an adhesive protocol including a bioactive glass-ceramic powder for 18 months post-procedure. However, there was a significant difference between group 2 and group 4 (p < 0.05) for marginal adaptation (18 months). Group 2 was significantly different from group 3 (p < 0.05) for fracture of material/retention (18 months) and marginal adaptation (1 week); group 2 showed a better performance.

Conclusion

Adhesive protocols can alter the clinical performance of posterior restorations in terms of marginal adaptation and the fracture of material/retention in CAD. Clinical significance: Adhesive protocols may influence the success of resin composite restorations in CAD; this is important because failure can lead to caries, re-incidence, and/or clinical re-work.

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Mineral density changes in bovine carious dentin after treatment with bioactive dental cements: a comparative micro-CT study

Abstract

Objectives

To evaluate the potential of conventional glass ionomer cement (GIC), Biodentine™, MTA, and Portland cement to induce mineral density changes in carious dentin compared to zinc oxide eugenol control cement (ZOE).

Materials and methods

Fifty blocks of bovine root dentin were prepared and a biofilm model using ATCC strains of S.mutans, S.sobrinus, and L.casei was used to promote artificial dentin lesions. After demineralization, the blocks were randomly divided into the five cement groups. Half of the surface of each specimen received the tested material and the other half was covered with wax (control). Samples were stored in phosphate buffered saline solution for 30 days and after that were scanned in a micro-CT with standardized parameters. Dentin mineral density changes were calculated using differences in plot profiles of the exposed and control carious dentin. Friedman's test, followed by Wilcoxon signed-rank test was used with 5% significance.

Results

Mean ΔZ values for the cements were 48.63 ± 19.09 for the control (ZOE), 63.31 ± 32.59 for Biodentine™, 114.63 ± 72.92 for GIC, 109.56 ± 66.28 for MTA, and 106.88 ± 66.02 for Portland cement. All cements showed a statistically significant increase in ΔZ values compared to the control, but Biodentine™ values were statistically significantly lower compared to GIC and the other calcium silicate cements.

Conclusions

Tested materials present potential to induce mineral density changes in carious bovine dentin. MTA, Portland, and GIC showed higher bioactivity potential than Biodentine™.

Clinical relevance

Based on minimally invasive concept, materials with remineralization potential can be used to preserve diseased but still repairable dental tissue.

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Clinical, double blind, randomized controlled trial of experimental adhesive protocols in caries-affected dentin

Abstract

Objective

To evaluate the clinical performance of posterior resin composite restorations regarding experimental and regular adhesive protocols in caries affected-dentin (CAD).

Material and methods

A total of 92 class I and class II cavities with carious lesions were selected and randomly assigned to the following groups: (1) bioactive glass-ceramic powder/two-step etch and rinse system, (2) control/two-step etch and rinse system, (3) bioactive glass-ceramic powder/two-step self-etching system, and (4) control/two-step self-etching system. Two operators carried out the adhesive protocols and restored the cavities with a nano-hybrid resin composite. Participants were followed up at 1 week and 6, 12, and 18 months for clinical evaluation performed by two blinded examiners and calibrated according to FDI criteria. Data were analyzed using Kruskal-Wallis and Dunn tests with a confidence of 95%.

Results

The clinical performance of resin composite restoration was not affected by the experimental use of an adhesive protocol including a bioactive glass-ceramic powder for 18 months post-procedure. However, there was a significant difference between group 2 and group 4 (p < 0.05) for marginal adaptation (18 months). Group 2 was significantly different from group 3 (p < 0.05) for fracture of material/retention (18 months) and marginal adaptation (1 week); group 2 showed a better performance.

Conclusion

Adhesive protocols can alter the clinical performance of posterior restorations in terms of marginal adaptation and the fracture of material/retention in CAD. Clinical significance: Adhesive protocols may influence the success of resin composite restorations in CAD; this is important because failure can lead to caries, re-incidence, and/or clinical re-work.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QC5b90

Mineral density changes in bovine carious dentin after treatment with bioactive dental cements: a comparative micro-CT study

Abstract

Objectives

To evaluate the potential of conventional glass ionomer cement (GIC), Biodentine™, MTA, and Portland cement to induce mineral density changes in carious dentin compared to zinc oxide eugenol control cement (ZOE).

Materials and methods

Fifty blocks of bovine root dentin were prepared and a biofilm model using ATCC strains of S.mutans, S.sobrinus, and L.casei was used to promote artificial dentin lesions. After demineralization, the blocks were randomly divided into the five cement groups. Half of the surface of each specimen received the tested material and the other half was covered with wax (control). Samples were stored in phosphate buffered saline solution for 30 days and after that were scanned in a micro-CT with standardized parameters. Dentin mineral density changes were calculated using differences in plot profiles of the exposed and control carious dentin. Friedman's test, followed by Wilcoxon signed-rank test was used with 5% significance.

Results

Mean ΔZ values for the cements were 48.63 ± 19.09 for the control (ZOE), 63.31 ± 32.59 for Biodentine™, 114.63 ± 72.92 for GIC, 109.56 ± 66.28 for MTA, and 106.88 ± 66.02 for Portland cement. All cements showed a statistically significant increase in ΔZ values compared to the control, but Biodentine™ values were statistically significantly lower compared to GIC and the other calcium silicate cements.

Conclusions

Tested materials present potential to induce mineral density changes in carious bovine dentin. MTA, Portland, and GIC showed higher bioactivity potential than Biodentine™.

Clinical relevance

Based on minimally invasive concept, materials with remineralization potential can be used to preserve diseased but still repairable dental tissue.

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Medical News Today: What to know about chicken allergies

While fish and seafood often cause allergies, chicken meat allergies are less common. The symptoms can vary from mild to very severe. In some cases, chicken allergies are related to bird egg allergies, though they can also exist separately. Chicken allergies may be linked to other bird allergies. Learn more here. (Source: Health News from Medical News Today)

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A Phonetic Complexity-Based Approach For Intelligibility and Articulatory Precision Testing: A Preliminary Study on Talkers With Amyotrophic Lateral Sclerosis.

Conclusions: Considering phonetic complexity for dysarthria tests could result in more sensitive assessments for detecting and monitoring dysarthria progression. PMID: 30208408 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Morphosyntax Production of Preschool Children With Hearing Loss: An Evaluation of the Extended Optional Infinitive and Surface Accounts.

Conclusions: Taken together, the findings of this study support a unified theoretical account of morphosyntax weakness in CHL in which both tense and duration of morphemes play a role in morphosyntax production accuracy, with a more robust role for tense than duration. PMID: 30208485 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Medical News Today: What to know about chicken allergies

While fish and seafood often cause allergies, chicken meat allergies are less common. The symptoms can vary from mild to very severe. In some cases, chicken allergies are related to bird egg allergies, though they can also exist separately. Chicken allergies may be linked to other bird allergies. Learn more here. (Source: Health News from Medical News Today)

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Reliability of Measures of N1 Peak Amplitude of the Compound Action Potential in Younger and Older Adults.

Conclusions: Our results suggest that measurements of AN activity can be robustly and reliably recorded in both younger and older adults using either peak-to-peak or baseline-corrected measurements of the N1 of the CAP. Peak-to-peak measurements yield larger N1 response amplitudes and are the default measurement type for many clinical systems, whereas baseline-corrected measurements are computationally simpler. Furthermore, the relationships between AN activity and stimulus- and participant-related variables were not affected by measurement technique, which suggests that these relationships can be compared across studies using different techniques for measuring the CAP N1. PMID: 30208403 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JS...

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The Impact of Exposure With No Training: Implications for Future Partner Training Research.

Conclusions: If the results of this small study are in any way representative of what happens in real life, communication partner training in aphasia becomes even more important than indicated from the positive results of training studies. That is, it is possible that mere exposure to a communication disability such as aphasia could have negative impacts on communication and social interaction. This may be akin to what is known as a "nocebo" effect-something for partner training studies in aphasia to take into account. PMID: 30208393 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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A Potential Bias in Subjective Ratings of Mental Effort.

Conclusions: Participants likely substitute an easier question when asked to rate the multidimensional construct of mental effort. The results presented here suggest that perceived performance can serve as a ready heuristic and may explain the dissociation between subjective measures of listening effort and behavioral and physiological measures. PMID: 30208416 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Diagnosing Middle Ear Pathology in 6- to 9-Month-Old Infants Using Wideband Absorbance: A Risk Prediction Model.

Conclusions: The risk prediction model had accurate discrimination and satisfactory calibration. Validation results indicate that it may generalize well to new infants. The model could potentially be used in diagnostic and screening settings. In the context of screening, probabilities provide an intuitive and flexible mechanism for setting the referral threshold that is sensitive to the costs associated with true and false-positive outcomes. In a diagnostic setting, predictions could be used to supplement visual inspection of absorbance for individualized diagnoses. Further research assessing the performance and impact of the model in these contexts is warranted. PMID: 30208481 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Perceptual Encoding in Auditory Brainstem Responses: Effects of Stimulus Frequency.

Conclusions: Results demonstrate that the ABR provides a useful measure of early perceptual encoding for stimuli varying in frequency and that the tonotopic organization of the auditory system is preserved at this stage of processing for stimuli from 500 to 8000 Hz. Such a measure may serve as a useful clinical tool for evaluating a listener's ability to encode specific frequencies in sounds. Supplemental Material: https://ift.tt/2Qeaviq. PMID: 30193361 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Exploring the Effects of Imitating Hand Gestures and Head Nods on L1 and L2 Mandarin Tone Production.

Conclusion: Results suggest that metaphoric bodily actions do not influence the lowest levels of L1 speech production in a tonal language and may play a very modest role during preliminary L2 learning. PMID: 30193334 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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A Phonetic Complexity-Based Approach For Intelligibility and Articulatory Precision Testing: A Preliminary Study on Talkers With Amyotrophic Lateral Sclerosis.

Conclusions: Considering phonetic complexity for dysarthria tests could result in more sensitive assessments for detecting and monitoring dysarthria progression. PMID: 30208408 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NftOtV

Morphosyntax Production of Preschool Children With Hearing Loss: An Evaluation of the Extended Optional Infinitive and Surface Accounts.

Conclusions: Taken together, the findings of this study support a unified theoretical account of morphosyntax weakness in CHL in which both tense and duration of morphemes play a role in morphosyntax production accuracy, with a more robust role for tense than duration. PMID: 30208485 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CVrseZ

Reliability of Measures of N1 Peak Amplitude of the Compound Action Potential in Younger and Older Adults.

Conclusions: Our results suggest that measurements of AN activity can be robustly and reliably recorded in both younger and older adults using either peak-to-peak or baseline-corrected measurements of the N1 of the CAP. Peak-to-peak measurements yield larger N1 response amplitudes and are the default measurement type for many clinical systems, whereas baseline-corrected measurements are computationally simpler. Furthermore, the relationships between AN activity and stimulus- and participant-related variables were not affected by measurement technique, which suggests that these relationships can be compared across studies using different techniques for measuring the CAP N1. PMID: 30208403 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JS...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CVq9g5

The Impact of Exposure With No Training: Implications for Future Partner Training Research.

Conclusions: If the results of this small study are in any way representative of what happens in real life, communication partner training in aphasia becomes even more important than indicated from the positive results of training studies. That is, it is possible that mere exposure to a communication disability such as aphasia could have negative impacts on communication and social interaction. This may be akin to what is known as a "nocebo" effect-something for partner training studies in aphasia to take into account. PMID: 30208393 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CWylwM

A Potential Bias in Subjective Ratings of Mental Effort.

Conclusions: Participants likely substitute an easier question when asked to rate the multidimensional construct of mental effort. The results presented here suggest that perceived performance can serve as a ready heuristic and may explain the dissociation between subjective measures of listening effort and behavioral and physiological measures. PMID: 30208416 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Facing the Challenges of Primary Progressive Aphasia: The Spousal Perspective.

Conclusions: Greater understanding of the spousal experiences of PPA is crucial to the development of intervention to help sustain spouses' emotional and relational connections with their partner. PMID: 30208478 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Perceptual Encoding in Auditory Brainstem Responses: Effects of Stimulus Frequency.

Conclusions: Results demonstrate that the ABR provides a useful measure of early perceptual encoding for stimuli varying in frequency and that the tonotopic organization of the auditory system is preserved at this stage of processing for stimuli from 500 to 8000 Hz. Such a measure may serve as a useful clinical tool for evaluating a listener's ability to encode specific frequencies in sounds. Supplemental Material: https://ift.tt/2Qeaviq. PMID: 30193361 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Erratum.

Authors: PMID: 30193369 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Exploring the Effects of Imitating Hand Gestures and Head Nods on L1 and L2 Mandarin Tone Production.

Conclusion: Results suggest that metaphoric bodily actions do not influence the lowest levels of L1 speech production in a tonal language and may play a very modest role during preliminary L2 learning. PMID: 30193334 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Correction to: A Comparison of Measurements of a Pediatric Supplement

The original version of this article unfortunately contained mistakes. (Source: Dysphagia)

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Correction to: A Comparison of Measurements of a Pediatric Supplement

The original version of this article unfortunately contained mistakes. (Source: Dysphagia)

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Cancer centre to soon launch in-patient, home care services

Cancer centre to soon launch in-patient, home care services  The HinduFull coverage

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Cancer centre to soon launch in-patient, home care services

Cancer centre to soon launch in-patient, home care services  The HinduFull coverage

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‘Atypical ’ Season 2 Adds Actors and Consultant With Autism

The Netflix series "Atypical" shares the story of a high school boy with autism facing the challenges of romance and achieving independence. The show originated last year and the second season recently aired. The first season was criticized for not using an actor with autism spectrum disorder (ASD) to play the main character, Sam. The show has responded with new episodes that include eight actors and a writing consultant who all have ASD. Through improv, teens with autism tap into their inner comedian while building social-communication skills.  Broadway Performances Aimed at Audiences With Autism Children who use AAC devices put on a play to show the world that communicating is more than talking. According to an article in The New York Times, the second season makes several changes...

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Medical News Today: Can people be allergic to strawberries?

Strawberry allergies are less common than other allergies, but they do occur. Most allergic reactions to strawberries are mild, but they can occasionally be life-threatening for some people. In this article, we look at the symptoms of this allergy as well as the risk factors and diagnosis. We also cover foods to avoid. (Source: Health News from Medical News Today)

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Situation Framing, Language Can Influence Decision - Making

Docs should provide risks of both having treatment and not having treatment to minimize loss aversion (Source: Pulmonary Medicine News - Doctors Lounge)

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FRESH program combines basic science with social benefits for women at risk of HIV

(Massachusetts General Hospital) A program established by the Ragon Institute of MGH, MIT and Harvard is addressing the persistently elevated risk of HIV infection among young women in South Africa from two angles -- first, investigating biological factors that modulate infection risk and the early immunologic events following viral exposure, and second, alleviating the socioeconomic factors that limit opportunities for young women, the group at greatest risk in the region hit hardest by the HIV epidemic. (Source: EurekAlert! - Medicine and Health)

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Study: Brain networks responsible for naming objects — (Details)

Study: Brain networks responsible for naming objects — (Details)  TdnewsFull coverage

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Medical News Today: Can people be allergic to strawberries?

Strawberry allergies are less common than other allergies, but they do occur. Most allergic reactions to strawberries are mild, but they can occasionally be life-threatening for some people. In this article, we look at the symptoms of this allergy as well as the risk factors and diagnosis. We also cover foods to avoid. (Source: Health News from Medical News Today)

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Situation Framing, Language Can Influence Decision - Making

Docs should provide risks of both having treatment and not having treatment to minimize loss aversion (Source: Pulmonary Medicine News - Doctors Lounge)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OngArG

FRESH program combines basic science with social benefits for women at risk of HIV

(Massachusetts General Hospital) A program established by the Ragon Institute of MGH, MIT and Harvard is addressing the persistently elevated risk of HIV infection among young women in South Africa from two angles -- first, investigating biological factors that modulate infection risk and the early immunologic events following viral exposure, and second, alleviating the socioeconomic factors that limit opportunities for young women, the group at greatest risk in the region hit hardest by the HIV epidemic. (Source: EurekAlert! - Medicine and Health)

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Study: Brain networks responsible for naming objects — (Details)

Study: Brain networks responsible for naming objects — (Details)  TdnewsFull coverage

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Situation Framing, Language Can Influence Decision - Making

Docs should provide risks of both having treatment and not having treatment to minimize loss aversion (Source: Pulmonary Medicine News - Doctors Lounge)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OngArG

FRESH program combines basic science with social benefits for women at risk of HIV

(Massachusetts General Hospital) A program established by the Ragon Institute of MGH, MIT and Harvard is addressing the persistently elevated risk of HIV infection among young women in South Africa from two angles -- first, investigating biological factors that modulate infection risk and the early immunologic events following viral exposure, and second, alleviating the socioeconomic factors that limit opportunities for young women, the group at greatest risk in the region hit hardest by the HIV epidemic. (Source: EurekAlert! - Medicine and Health)

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Medical News Today: Can people be allergic to strawberries?

Strawberry allergies are less common than other allergies, but they do occur. Most allergic reactions to strawberries are mild, but they can occasionally be life-threatening for some people. In this article, we look at the symptoms of this allergy as well as the risk factors and diagnosis. We also cover foods to avoid. (Source: Health News from Medical News Today)

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Situation Framing, Language Can Influence Decision - Making

Docs should provide risks of both having treatment and not having treatment to minimize loss aversion (Source: Pulmonary Medicine News - Doctors Lounge)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OngArG

‘Atypical ’ Season 2 Adds Actors and Consultant With Autism

The Netflix series "Atypical" shares the story of a high school boy with autism facing the challenges of romance and achieving independence. The show originated last year and the second season recently aired. The first season was criticized for not using an actor with autism spectrum disorder (ASD) to play the main character, Sam. The show has responded with new episodes that include eight actors and a writing consultant who all have ASD. Through improv, teens with autism tap into their inner comedian while building social-communication skills.  Broadway Performances Aimed at Audiences With Autism Children who use AAC devices put on a play to show the world that communicating is more than talking. According to an article in The New York Times, the second season makes several changes...

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A Systematic Review and Meta-analysis: Do Absorbable or Non-Absorbable Suture Materials Differ in Cosmetic Outcomes in Patients Requiring Primary Closure of Facial Wounds?

Surgeons are often judged on the cosmetic appearance of any scar after surgery rather than the functional outcome of treatment, especially when considering facial wounds.

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Head And Neck Cancer Treatment Market Analysis, Size, Share, Key Player, Trends and Forecast to 2021

Head And Neck Cancer Treatment Market Analysis, Size, Share, Key Player, Trends and Forecast to 2021  Our Market ResearchFull coverage

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‘Atypical ’ Season 2 Adds Actors and Consultant With Autism

The Netflix series "Atypical" shares the story of a high school boy with autism facing the challenges of romance and achieving independence. The show originated last year and the second season recently aired. The first season was criticized for not using an actor with autism spectrum disorder (ASD) to play the main character, Sam. The show has responded with new episodes that include eight actors and a writing consultant who all have ASD. Through improv, teens with autism tap into their inner comedian while building social-communication skills.  Broadway Performances Aimed at Audiences With Autism Children who use AAC devices put on a play to show the world that communicating is more than talking. According to an article in The New York Times, the second season makes several changes...

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A Systematic Review and Meta-analysis: Do Absorbable or Non-Absorbable Suture Materials Differ in Cosmetic Outcomes in Patients Requiring Primary Closure of Facial Wounds?

Surgeons are often judged on the cosmetic appearance of any scar after surgery rather than the functional outcome of treatment, especially when considering facial wounds.

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Head And Neck Cancer Treatment Market Analysis, Size, Share, Key Player, Trends and Forecast to 2021

Head And Neck Cancer Treatment Market Analysis, Size, Share, Key Player, Trends and Forecast to 2021  Our Market ResearchFull coverage

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Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis

The aim of this systematic review was to determine whether bromelain is an effective drug for the control of pain and inflammation associated with third molar surgery. Randomized, controlled clinical trials on the subject were identified through a systematic search of the literature using the PubMed/MEDLINE, Scopus, and Cochrane Library databases. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Two independent, blinded reviewers selected studies based on the inclusion criteria.

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Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis

The aim of this systematic review was to determine whether bromelain is an effective drug for the control of pain and inflammation associated with third molar surgery. Randomized, controlled clinical trials on the subject were identified through a systematic search of the literature using the PubMed/MEDLINE, Scopus, and Cochrane Library databases. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Two independent, blinded reviewers selected studies based on the inclusion criteria.

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Comparison of temporalis fascia and tragal cartilage grafts in type 1 tympanoplasty in elderly patients

To investigate the success rates and hearing outcomes of temporalis fascia and tragal cartilage grafts used for type-1 tympanoplasty in the elderly (³65 years)

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Global Head And Neck Cancer Drugs Therapeutics Market 2018 | Industry Key Players, Type, Applications, world's ...

Global Head And Neck Cancer Drugs Therapeutics Market 2018 | Industry Key Players, Type, Applications, world's ...  firstpharmacist.comFull coverage

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Comparison of temporalis fascia and tragal cartilage grafts in type 1 tympanoplasty in elderly patients

To investigate the success rates and hearing outcomes of temporalis fascia and tragal cartilage grafts used for type-1 tympanoplasty in the elderly (³65 years)

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Global Head And Neck Cancer Drugs Therapeutics Market 2018 | Industry Key Players, Type, Applications, world's ...

Global Head And Neck Cancer Drugs Therapeutics Market 2018 | Industry Key Players, Type, Applications, world's ...  firstpharmacist.comFull coverage

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A Simplified Dose Schedule of Cetuximab as a Maintenance Therapy in Head and Neck Cancer May Reduce Drug ...

A Simplified Dose Schedule of Cetuximab as a Maintenance Therapy in Head and Neck Cancer May Reduce Drug ...  Cancer Therapy AdvisorFull coverage

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A Simplified Dose Schedule of Cetuximab as a Maintenance Therapy in Head and Neck Cancer May Reduce Drug ...

A Simplified Dose Schedule of Cetuximab as a Maintenance Therapy in Head and Neck Cancer May Reduce Drug ...  Cancer Therapy AdvisorFull coverage

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Discovery suggests which thyroid cancer patients may need more aggressive treatment

Discovery suggests which thyroid cancer patients may need more aggressive treatment  Medical XpressFull coverage

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Discovery suggests which thyroid cancer patients may need more aggressive treatment

Discovery suggests which thyroid cancer patients may need more aggressive treatment  Medical XpressFull coverage

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