No abstract available
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Κυριακή 16 Σεπτεμβρίου 2018
Temporal Changes in Ventilator Settings in Patients With Uninjured Lungs: A Systematic Review
In patients with uninjured lungs, increasing evidence indicates that tidal volume (VT) reduction improves outcomes in the intensive care unit (ICU) and in the operating room (OR). However, the degree to which this evidence has translated to clinical changes in ventilator settings for patients with uninjured lungs is unknown. To clarify whether ventilator settings have changed, we searched MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science for publications on invasive ventilation in ICUs or ORs, excluding those on patients 25% of patients with acute respiratory distress syndrome (ARDS). Our primary end point was temporal change in VT over time. Secondary end points were changes in maximum airway pressure, mean airway pressure, positive end-expiratory pressure, inspiratory oxygen fraction, development of ARDS (ICU studies only), and postoperative pulmonary complications (OR studies only) determined using correlation analysis and linear regression. We identified 96 ICU and 96 OR studies comprising 130,316 patients from 1975 to 2014 and observed that in the ICU, VT size decreased annually by 0.16 mL/kg (−0.19 to −0.12 mL/kg) (P
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Teaching Medical Students Clinical Anesthesia: A View From the United Kingdom
Anesthetics and Trauma: A Complex Interaction
Vertical and Horizontal Pathways: Intersection and Integration of Enhanced Recovery After Surgery and the Perioperative Surgical Home
Surveying the Literature: Synopsis of Recent Key Publications
In Response
Perioperative Outcomes and Surgical Case Volume in Pediatric Complex Cranial Vault Reconstruction: A Multicenter Observational Study From the Pediatric Craniofacial Collaborative Group
BACKGROUND: Complex cranial vault reconstruction (CCVR) performed to treat craniosynostosis can be associated with significant blood loss, transfusion, and perioperative complications. The aim of this study was to examine the effect of CCVR surgical case volume on perioperative outcomes. We hypothesized that surgical case volume is not associated with differences in perioperative outcomes. The study primary outcome was total perioperative blood donor exposures. Secondary outcomes included the total perioperative transfusion volume, major complications, and intensive care unit and hospital length of stay. METHODS: The multicenter Pediatric Surgery Perioperative Registry was queried for infants and children undergoing CCVR between June 2012 and September 2016. Institutions were categorized into low, middle, or high surgical case volume groups based on tertiles of the average number of cases performed per month. Primary and secondary outcomes were analyzed with respect to these groupings. RESULTS: The query yielded 1814 CCVR cases from 33 institutions. Demographics were similar among the 3 study groups. An inverse relationship between surgical case volume and total perioperative blood donor exposures was observed (P
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Point-of-Care Ultrasound Abnormalities in Late-Onset Severe Preeclampsia: Prevalence and Association With Serum Albumin and Brain Natriuretic Peptide
BACKGROUND: Pilot studies applying point-of-care ultrasound (POCUS) in preeclampsia indicate the presence of pulmonary interstitial edema, cerebral edema, and cardiac dysfunction. Laboratory markers of oncotic pressure (albumin) and cardiac dysfunction (brain natriuretic peptide [BNP]) may be abnormal, but the clinical application remains unclear. We investigated the prevalence of pulmonary interstitial syndrome (PIS), cardiac dysfunction, and increased optic nerve sheath diameter (ONSD) in late-onset preeclampsia with severe features. The primary aim was to examine the association between PIS or ONSD and maternal serum albumin level. The secondary aims were to explore the association between cardiac dysfunction and PIS, ONSD, BNP, and serum albumin level and between POCUS-derived parameters and a suspicious or pathological cardiotocograph. METHODS: Ninety-five women were enrolled in this prospective observational cohort study. A POCUS examination of lungs, heart, and ONSD was performed. PIS was defined as a bilateral B-line pattern on lung ultrasound and diastolic dysfunction according to an algorithm of the American Society of Echocardiography. ONSD >5.8 mm was interpreted as compatible with raised intracranial pressure (>20 mm Hg). Serum BNP and albumin levels were also measured. RESULTS: PIS, diastolic dysfunction, systolic dysfunction, and raised left ventricular end-diastolic pressure (LVEDP) were present in 23 (24%), 31 (33%), 9 (10%), and 20 (25%) women, respectively. ONSD was increased in 27 (28%) women. Concerning the primary outcome, there was no association between albumin level and PIS (P = .4) or ONSD (P = .63). With respect to secondary outcomes, there was no association between albumin level and systolic dysfunction (P = .21) or raised LVEDP (P = .44). PIS was associated with diastolic dysfunction (P = .02) and raised LVEDP (P = .009; negative predictive value, 85%). BNP level was associated with systolic (P
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research Wicked Local WeymouthFull coverage |
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UN seeks to open air bridge to aid Yemeni cancer patients: WHO
| UN seeks to open air bridge to aid Yemeni cancer patients: WHO The Japan TimesFull coverage |
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Medical Catastrophe: Confessions of an Anesthesiologist
Temporal Changes in Ventilator Settings in Patients With Uninjured Lungs: A Systematic Review
In patients with uninjured lungs, increasing evidence indicates that tidal volume (VT) reduction improves outcomes in the intensive care unit (ICU) and in the operating room (OR). However, the degree to which this evidence has translated to clinical changes in ventilator settings for patients with uninjured lungs is unknown. To clarify whether ventilator settings have changed, we searched MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science for publications on invasive ventilation in ICUs or ORs, excluding those on patients 25% of patients with acute respiratory distress syndrome (ARDS). Our primary end point was temporal change in VT over time. Secondary end points were changes in maximum airway pressure, mean airway pressure, positive end-expiratory pressure, inspiratory oxygen fraction, development of ARDS (ICU studies only), and postoperative pulmonary complications (OR studies only) determined using correlation analysis and linear regression. We identified 96 ICU and 96 OR studies comprising 130,316 patients from 1975 to 2014 and observed that in the ICU, VT size decreased annually by 0.16 mL/kg (−0.19 to −0.12 mL/kg) (P
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OAZhmQ
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OAZhmQ
Teaching Medical Students Clinical Anesthesia: A View From the United Kingdom
Anesthetics and Trauma: A Complex Interaction
Vertical and Horizontal Pathways: Intersection and Integration of Enhanced Recovery After Surgery and the Perioperative Surgical Home
Surveying the Literature: Synopsis of Recent Key Publications
In Response
Perioperative Outcomes and Surgical Case Volume in Pediatric Complex Cranial Vault Reconstruction: A Multicenter Observational Study From the Pediatric Craniofacial Collaborative Group
BACKGROUND: Complex cranial vault reconstruction (CCVR) performed to treat craniosynostosis can be associated with significant blood loss, transfusion, and perioperative complications. The aim of this study was to examine the effect of CCVR surgical case volume on perioperative outcomes. We hypothesized that surgical case volume is not associated with differences in perioperative outcomes. The study primary outcome was total perioperative blood donor exposures. Secondary outcomes included the total perioperative transfusion volume, major complications, and intensive care unit and hospital length of stay. METHODS: The multicenter Pediatric Surgery Perioperative Registry was queried for infants and children undergoing CCVR between June 2012 and September 2016. Institutions were categorized into low, middle, or high surgical case volume groups based on tertiles of the average number of cases performed per month. Primary and secondary outcomes were analyzed with respect to these groupings. RESULTS: The query yielded 1814 CCVR cases from 33 institutions. Demographics were similar among the 3 study groups. An inverse relationship between surgical case volume and total perioperative blood donor exposures was observed (P
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xjN0N6
Point-of-Care Ultrasound Abnormalities in Late-Onset Severe Preeclampsia: Prevalence and Association With Serum Albumin and Brain Natriuretic Peptide
BACKGROUND: Pilot studies applying point-of-care ultrasound (POCUS) in preeclampsia indicate the presence of pulmonary interstitial edema, cerebral edema, and cardiac dysfunction. Laboratory markers of oncotic pressure (albumin) and cardiac dysfunction (brain natriuretic peptide [BNP]) may be abnormal, but the clinical application remains unclear. We investigated the prevalence of pulmonary interstitial syndrome (PIS), cardiac dysfunction, and increased optic nerve sheath diameter (ONSD) in late-onset preeclampsia with severe features. The primary aim was to examine the association between PIS or ONSD and maternal serum albumin level. The secondary aims were to explore the association between cardiac dysfunction and PIS, ONSD, BNP, and serum albumin level and between POCUS-derived parameters and a suspicious or pathological cardiotocograph. METHODS: Ninety-five women were enrolled in this prospective observational cohort study. A POCUS examination of lungs, heart, and ONSD was performed. PIS was defined as a bilateral B-line pattern on lung ultrasound and diastolic dysfunction according to an algorithm of the American Society of Echocardiography. ONSD >5.8 mm was interpreted as compatible with raised intracranial pressure (>20 mm Hg). Serum BNP and albumin levels were also measured. RESULTS: PIS, diastolic dysfunction, systolic dysfunction, and raised left ventricular end-diastolic pressure (LVEDP) were present in 23 (24%), 31 (33%), 9 (10%), and 20 (25%) women, respectively. ONSD was increased in 27 (28%) women. Concerning the primary outcome, there was no association between albumin level and PIS (P = .4) or ONSD (P = .63). With respect to secondary outcomes, there was no association between albumin level and systolic dysfunction (P = .21) or raised LVEDP (P = .44). PIS was associated with diastolic dysfunction (P = .02) and raised LVEDP (P = .009; negative predictive value, 85%). BNP level was associated with systolic (P
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research Wicked Local WeymouthFull coverage |
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UN seeks to open air bridge to aid Yemeni cancer patients: WHO
| UN seeks to open air bridge to aid Yemeni cancer patients: WHO The Japan TimesFull coverage |
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Characteristics of Excited Triplet States of Thiolated Guanosine Derivatives and Singlet Oxygen Generation
Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00240A, Paper
DOI: 10.1039/C8PP00240A, Paper
Shoma Miyata, Shunsuke Tanabe, Tasuku Isozaki, Yao-Zhong Xu, Tadashi Suzuki
Thioguanine is sensitive to UVA light and generates singlet molecular oxygen (1O2*) when exposed to UVA. Three thioguanosine derivatives, 2',3',5'–tri–O–acetyl–6–thioguanosine (ta6TGuo), 2',3',5'–tri–O–acetyl–8–thioguanosine (ta8TGuo), and 2',3',5'–tri–O–acetyl–6,8–dithioguanosine (taDTGuo) were explored photophysically and...
The content of this RSS Feed (c) The Royal Society of Chemistry
Thioguanine is sensitive to UVA light and generates singlet molecular oxygen (1O2*) when exposed to UVA. Three thioguanosine derivatives, 2',3',5'–tri–O–acetyl–6–thioguanosine (ta6TGuo), 2',3',5'–tri–O–acetyl–8–thioguanosine (ta8TGuo), and 2',3',5'–tri–O–acetyl–6,8–dithioguanosine (taDTGuo) were explored photophysically and...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Characteristics of Excited Triplet States of Thiolated Guanosine Derivatives and Singlet Oxygen Generation
Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00240A, Paper
DOI: 10.1039/C8PP00240A, Paper
Shoma Miyata, Shunsuke Tanabe, Tasuku Isozaki, Yao-Zhong Xu, Tadashi Suzuki
Thioguanine is sensitive to UVA light and generates singlet molecular oxygen (1O2*) when exposed to UVA. Three thioguanosine derivatives, 2',3',5'–tri–O–acetyl–6–thioguanosine (ta6TGuo), 2',3',5'–tri–O–acetyl–8–thioguanosine (ta8TGuo), and 2',3',5'–tri–O–acetyl–6,8–dithioguanosine (taDTGuo) were explored photophysically and...
The content of this RSS Feed (c) The Royal Society of Chemistry
Thioguanine is sensitive to UVA light and generates singlet molecular oxygen (1O2*) when exposed to UVA. Three thioguanosine derivatives, 2',3',5'–tri–O–acetyl–6–thioguanosine (ta6TGuo), 2',3',5'–tri–O–acetyl–8–thioguanosine (ta8TGuo), and 2',3',5'–tri–O–acetyl–6,8–dithioguanosine (taDTGuo) were explored photophysically and...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Nigerian Federal Ministry of Health to Launch Pilot Cancer Drug Access Program with BIO Ventures for Global Health
| Nigerian Federal Ministry of Health to Launch Pilot Cancer Drug Access Program with BIO Ventures for Global Health Odessa AmericanFull coverage |
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Botox Effect Lasts Longer At Higher Doses, TEVA Gets FDA Nod, KNSA On Watch
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Nigerian Federal Ministry of Health to Launch Pilot Cancer Drug Access Program with BIO Ventures for Global Health
| Nigerian Federal Ministry of Health to Launch Pilot Cancer Drug Access Program with BIO Ventures for Global Health Odessa AmericanFull coverage |
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Botox Effect Lasts Longer At Higher Doses, TEVA Gets FDA Nod, KNSA On Watch
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[Hearing aid provision in children].
Authors: Läßig AK, Kettern L, Kugelstadt S, Bohnert A Abstract Achieving high-quality hearing aid fitting in children is an interdisciplinary task and a challenge for all involved specialist disciplines. According to quality agreements (standards), comparative hearing aid fitting is mandatory prior to prescription. Furthermore, RECD measurements and, in older children, in-situ measurements should be applied on a regular basis for finetuning and adjustment of the hearing aid fitting. ENT physicians, phoniatricians and pediatric audiologists, pediatric acousticians, teachers of the hearing impaired, and special educational needs teachers should work together in an interdisciplinary approach. PMID: 30215108 [PubMed - as supplied by publisher] (Source: HNO)
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[Hearing aid provision in children].
Authors: Läßig AK, Kettern L, Kugelstadt S, Bohnert A Abstract Achieving high-quality hearing aid fitting in children is an interdisciplinary task and a challenge for all involved specialist disciplines. According to quality agreements (standards), comparative hearing aid fitting is mandatory prior to prescription. Furthermore, RECD measurements and, in older children, in-situ measurements should be applied on a regular basis for finetuning and adjustment of the hearing aid fitting. ENT physicians, phoniatricians and pediatric audiologists, pediatric acousticians, teachers of the hearing impaired, and special educational needs teachers should work together in an interdisciplinary approach. PMID: 30215108 [PubMed - as supplied by publisher] (Source: HNO)
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FIERCE for a cure: Natick boot camp raises money for cancer research
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Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...
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FIERCE for a cure: Natick boot camp raises money for cancer research
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Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...
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Preliminary study on chronic granulomatous disease in Sri Lanka
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency of the phagocytic cells, which results in absent or diminished levels of microbicidal reactive oxygen species. The disease occurs due to g...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Or8u1b
Preliminary study on chronic granulomatous disease in Sri Lanka
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency of the phagocytic cells, which results in absent or diminished levels of microbicidal reactive oxygen species. The disease occurs due to g...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Or8u1b
Botox Effect Lasts Longer At Higher Doses, TEVA Gets FDA Nod, KNSA On Watch
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Botox Effect Lasts Longer At Higher Doses, TEVA Gets FDA Nod, KNSA On Watch
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“AIR LEAK SYNDROME”: An Unusual Presentation of Foreign Body in the Airway
Abstract
Spontaneous onset pneumomediastinum, pneumothorax and subcutaneous emphysema are rare presentations of a foreign body in the airway. The possible mechanism for unexplainable and non traumatic subcutaneous emphysema can be attributed to "Air leak syndrome" following inhalation of foreign body in the airway.
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Role of Proton Pump Inhibitors in Laryngopharyngeal Reflux: Clinical Evaluation in a North Indian Population
Abstract
There has been an escalation of patients presenting with symptoms of Laryngopharyngeal reflux disease (LPRD) in the otorhinolaryngology clinics due to life style and dietary changes. This study was undertaken to evaluate the effect of various proton pump inhibitors in the treatment of LPRD using Reflux symptom index (RSI) and Reflux finding score (RFS). This was a prospective study conducted from June 2016 to February 2017 with a total of 240 patients with symptoms and signs of LPR. The patients were divided into 5 groups. Each group was subjected to particular proton pump inhibitor. There were 124 males 116 females with a mean age 34.3 and rural to urban ratio being 11. After 3 months, RFS and RSI score within each group, improved significantly with Proton pump inhibitor therapy. In our study patients who were treated with omeprazole 20 mg twice daily had the highest improvement in laryngeal symptoms and laryngeal findings. We conclude emphasizing the effectiveness of proton pump inhibitors with incorporation of lifestyle modification in the successful management of LPRD.
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The Prevalence and Causes of Auditory Neuropathy/Dys-synchrony (AN/AD) in Children with Hearing Impairment
Abstract
There are a wide variety of hearing impairments that part of it is auditory neuropathy/dys-synchrony (AN/AD). So, the object of this study was determination the prevalence and causes of AN/AD in children with hearing impairment. This study was a descriptive cross-sectional survey. The sample size consisted of 105 hearing impairment children. All them were under hearing screening tests (tympanometry), distortion and transient evoked otoacoustic emissions (DPOAEs + TEOAE) and automated auditory brainstem response (AABR). If they were suspected to AN/AD, for complete diagnostic measurements were referred to our hospital. Four cases (8 ears) with AN/AD were diagnosed, which had an average age 37 months (SD = 8.67). So, the prevalence of AN/AD was 3.8 % among hearing impaired children. The findings of this study showed that there are the relationships between AN/AD and fluctuating hearing loss, acoustic reflex, high bilirubin, blood exchange after birth, neonatal intensive (NICU) care unit (P < 0.05). The simultaneous use of both ABR and OAE tests in the birth screening provide much more useful information than when each of these tests is used alone.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NkqUEo
“AIR LEAK SYNDROME”: An Unusual Presentation of Foreign Body in the Airway
Abstract
Spontaneous onset pneumomediastinum, pneumothorax and subcutaneous emphysema are rare presentations of a foreign body in the airway. The possible mechanism for unexplainable and non traumatic subcutaneous emphysema can be attributed to "Air leak syndrome" following inhalation of foreign body in the airway.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NmqzBe
Role of Proton Pump Inhibitors in Laryngopharyngeal Reflux: Clinical Evaluation in a North Indian Population
Abstract
There has been an escalation of patients presenting with symptoms of Laryngopharyngeal reflux disease (LPRD) in the otorhinolaryngology clinics due to life style and dietary changes. This study was undertaken to evaluate the effect of various proton pump inhibitors in the treatment of LPRD using Reflux symptom index (RSI) and Reflux finding score (RFS). This was a prospective study conducted from June 2016 to February 2017 with a total of 240 patients with symptoms and signs of LPR. The patients were divided into 5 groups. Each group was subjected to particular proton pump inhibitor. There were 124 males 116 females with a mean age 34.3 and rural to urban ratio being 11. After 3 months, RFS and RSI score within each group, improved significantly with Proton pump inhibitor therapy. In our study patients who were treated with omeprazole 20 mg twice daily had the highest improvement in laryngeal symptoms and laryngeal findings. We conclude emphasizing the effectiveness of proton pump inhibitors with incorporation of lifestyle modification in the successful management of LPRD.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OusgZR
The Prevalence and Causes of Auditory Neuropathy/Dys-synchrony (AN/AD) in Children with Hearing Impairment
Abstract
There are a wide variety of hearing impairments that part of it is auditory neuropathy/dys-synchrony (AN/AD). So, the object of this study was determination the prevalence and causes of AN/AD in children with hearing impairment. This study was a descriptive cross-sectional survey. The sample size consisted of 105 hearing impairment children. All them were under hearing screening tests (tympanometry), distortion and transient evoked otoacoustic emissions (DPOAEs + TEOAE) and automated auditory brainstem response (AABR). If they were suspected to AN/AD, for complete diagnostic measurements were referred to our hospital. Four cases (8 ears) with AN/AD were diagnosed, which had an average age 37 months (SD = 8.67). So, the prevalence of AN/AD was 3.8 % among hearing impaired children. The findings of this study showed that there are the relationships between AN/AD and fluctuating hearing loss, acoustic reflex, high bilirubin, blood exchange after birth, neonatal intensive (NICU) care unit (P < 0.05). The simultaneous use of both ABR and OAE tests in the birth screening provide much more useful information than when each of these tests is used alone.
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research Wicked Local ActonFull coverage |
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UN seeks to open air bridge to aid Yemeni cancer patients: WHO
| UN seeks to open air bridge to aid Yemeni cancer patients: WHO The Japan TimesHumanitarian Medical Air Bridge in Yemen ReliefwebFull coverage |
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Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xfY7Xi
FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research Wicked Local ActonFull coverage |
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOA0sf
UN seeks to open air bridge to aid Yemeni cancer patients: WHO
| UN seeks to open air bridge to aid Yemeni cancer patients: WHO The Japan TimesHumanitarian Medical Air Bridge in Yemen ReliefwebFull coverage |
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MC6AsN
Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...
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Preliminary study on chronic granulomatous disease in Sri Lanka
Abstract
Background
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency of the phagocytic cells, which results in absent or diminished levels of microbicidal reactive oxygen species. The disease occurs due to germline mutations in the genes encoding the five subunits of NADPH oxidase complex. The present study is a pilot study to understand the clinical and genetic aspects of CGD in Sri Lanka.
Methods
Clinical records of thirteen CGD patients were analysed and compared with similar studies performed in different countries and regions to identify patterns in demographics, clinical manifestations and infectious agents. Genomic DNA and cDNA were analysed in eight patients to identify mutations in CYBB and NCF1 genes, thereby to ascertain the potential X-linked and autosomal recessive (AR) CGD patients.
Results
The onset of symptoms in the patient cohort was very early (mean 4.6 months) compared to 20 months in India and 23.9 months in Latin America. Similarly, the age at diagnosis was lower (mean 1.6 years after birth) compared to other studies; 4.5 years in India and 6.1 years in Europe. Pulmonary manifestations were the most common (85%), followed by skin/subcutaneous infections (77%) and lymphadenopathy (62%). The death rate of local patients (38%) was higher than other countries (India 35%, Europe 20%). Majority (77%) were treated for tuberculosis at some point in life. Genetic analysis confirmed six out of eight patients as X-linked CGD cases with mutations in CYBB gene. A novel splice site mutation was identified in P-07 at position c.141+6 which resulted in the deletion of entire exon 2. Two siblings (P-05 and P-06) from consanguineous parents, were identified with AR-CGD based on the homozygous GT deletion mutation in NCF1 gene.
Conclusions
The clinical presentation, manifestations and genetic subtypes in the local cohort, appear to be comparable with global trends. Mycobacterial infections should be investigated and treated with more prominence. Effective treatment options are required to control the high mortality rate.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QBOev9
Preliminary study on chronic granulomatous disease in Sri Lanka
Abstract
Background
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency of the phagocytic cells, which results in absent or diminished levels of microbicidal reactive oxygen species. The disease occurs due to germline mutations in the genes encoding the five subunits of NADPH oxidase complex. The present study is a pilot study to understand the clinical and genetic aspects of CGD in Sri Lanka.
Methods
Clinical records of thirteen CGD patients were analysed and compared with similar studies performed in different countries and regions to identify patterns in demographics, clinical manifestations and infectious agents. Genomic DNA and cDNA were analysed in eight patients to identify mutations in CYBB and NCF1 genes, thereby to ascertain the potential X-linked and autosomal recessive (AR) CGD patients.
Results
The onset of symptoms in the patient cohort was very early (mean 4.6 months) compared to 20 months in India and 23.9 months in Latin America. Similarly, the age at diagnosis was lower (mean 1.6 years after birth) compared to other studies; 4.5 years in India and 6.1 years in Europe. Pulmonary manifestations were the most common (85%), followed by skin/subcutaneous infections (77%) and lymphadenopathy (62%). The death rate of local patients (38%) was higher than other countries (India 35%, Europe 20%). Majority (77%) were treated for tuberculosis at some point in life. Genetic analysis confirmed six out of eight patients as X-linked CGD cases with mutations in CYBB gene. A novel splice site mutation was identified in P-07 at position c.141+6 which resulted in the deletion of entire exon 2. Two siblings (P-05 and P-06) from consanguineous parents, were identified with AR-CGD based on the homozygous GT deletion mutation in NCF1 gene.
Conclusions
The clinical presentation, manifestations and genetic subtypes in the local cohort, appear to be comparable with global trends. Mycobacterial infections should be investigated and treated with more prominence. Effective treatment options are required to control the high mortality rate.
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POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project
Abstract
Allergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health). It will use a freely-existing application for AR monitoring that has been tested in 23 countries (the Allergy Diary, iOS and Android, 17,000 users, TLR8). The Allergy Diary will be combined with a new tool allowing queries on allergen, pollen (TLR2), sleep quality and disorders (TRL2) as well as existing longitudinal and geolocalized pollution data. Machine learning will be used to assess the relationship between air pollution, sleep and AR comparing polluted and non-polluted areas in 6 EU countries. Data generated in 2018 will be confirmed in 2019 and extended by the individual prospective assessment of pollution (portable sensor, TLR7) in AR. Sleep apnea patients will be used as a demonstrator of sleep disorder that can be modulated in terms of symptoms and severity by air pollution and AR. The geographic information system GIS will map the results. Consequences on quality of life (EQ-5D), asthma, school, work and sleep will be monitored and disseminated towards the population. The impacts of POLLAR will be (1) to propose novel care pathways integrating pollution, sleep and patients' literacy, (2) to study sleep consequences of pollution and its impact on frequent chronic diseases, (3) to improve work productivity, (4) to propose the basis for a sentinel network at the EU level for pollution and allergy, (5) to assess the societal implications of the interaction. MASK paper N°32.
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POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project
Abstract
Allergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health). It will use a freely-existing application for AR monitoring that has been tested in 23 countries (the Allergy Diary, iOS and Android, 17,000 users, TLR8). The Allergy Diary will be combined with a new tool allowing queries on allergen, pollen (TLR2), sleep quality and disorders (TRL2) as well as existing longitudinal and geolocalized pollution data. Machine learning will be used to assess the relationship between air pollution, sleep and AR comparing polluted and non-polluted areas in 6 EU countries. Data generated in 2018 will be confirmed in 2019 and extended by the individual prospective assessment of pollution (portable sensor, TLR7) in AR. Sleep apnea patients will be used as a demonstrator of sleep disorder that can be modulated in terms of symptoms and severity by air pollution and AR. The geographic information system GIS will map the results. Consequences on quality of life (EQ-5D), asthma, school, work and sleep will be monitored and disseminated towards the population. The impacts of POLLAR will be (1) to propose novel care pathways integrating pollution, sleep and patients' literacy, (2) to study sleep consequences of pollution and its impact on frequent chronic diseases, (3) to improve work productivity, (4) to propose the basis for a sentinel network at the EU level for pollution and allergy, (5) to assess the societal implications of the interaction. MASK paper N°32.
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POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project
AbstractAllergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health). It will use a freely-existing application for AR monitoring that has been tested in 23 countries (theAllergy Diary, iOS and Android, 17,000 users, TLR8). The Allergy Diary will be combined with a new tool allowing queries on allergen, pollen (TLR2), sleep quality and disorders (TRL2) as well as existing longitudinal and geolocalized pollution data. Machine learning will be used to assess the relationship between air pollution, sleep and AR comparing polluted and non-polluted ar...
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Molecular characterization and functional analysis of IL-12p40 from Chinese sea bass (Lateolabrax maculatus) under biotic and abiotic stresses
Publication date: Available online 15 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Xiang Chen, Pengfei Wang, Chao Zhao, Lulu Yan, Heizhao Lin, Lihua QiuAbstractInterleukins are critical cytokines that are ubiquitously present in both vertebrates and invertebrates and constitute the front line of host innate immunity. Here, we identified and analyzed IL-12p40 from the Chinese sea bass Lateolabrax maculatus (LmIL-12p40). The LmIL-12p40 gene is expressed as a 1386-base pair transcript that encodes a polypeptide of 321 amino acids. Transcriptional expression analysis indicated that LmIL-12p40 mRNA was ubiquitously expressed in all tested tissues and had a comparatively high expression level in immune-associated tissues (head-kidney and intestines). Quantitative reverse-transcrip...
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Physiopathological responses of sole (Solea senegalensis) subjected to bacterial infection and handling stress after probiotic treatment with autochthonous bacteria
This study aimed to evaluate the protective effects of four autochthonous bacteria isolated from juvenile sole (Solea senegalensis) intestine as dietary probiotic supplement against bacterial pathogen infection and handling/transport stressors. Growth performance and immune responses were evaluated after 85 days of feeding trial. Sole (IBW = 16.07 ± 0.11 g) were fed six experimental diets, a control diet (CTRL, without the dietary probiotic supplementation), and five diets supplemented with probiotic bacteria: PB1 (Shewanella hafniensis), PB2 (Enterococcus raffinosus), PB3 (Shewanella hafniensis + Arthrobacter soli), PB4 (Pseudomonas protegens + Arthrobacter soli) and PB5 (Shewanella hafniensis + Arthrobacter soli + Enterococcus raffinosus). All bacteria were selected ba...
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Ontogeny of lymphoid organs and mucosal associated lymphoid tissues in meagre (Argyrosomus regius)
This study investigates the development of lymphoid organs and mucosal tissues in larval and juvenile meagre, Argyrosomus regius. For this purpose, meagre larvae were reared from hatch to the juvenile stage, under mesocosm conditions at 18–19 °C, using standard feeding sequences with live prey and artificial food. The kidney was evident upon hatch and included a visible pronephros, with undifferentiated stem cells and excretory tubules at 1 dph (3.15 ± 0.1 mm SL). The thymus was first detected 8 dph (4.49 ± 0.39 mm SL) and was clearly visible 12 dph (5.69 ± 0.76 mm SL), 33 dph (15.69 ± 1.81 mm SL) an outer thymocytic zone and inner epithelial zone were visible. The spleen was present 12 dph, located between exocrine pancreas and intestine and by 26 dph (11....
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Transcriptome analysis and histopathology of black carp (Mylopharyngodon piceus) spleen infected by Aeromonas hydrophila
In this study, we analyzed the spleen of disease-resistant and susceptible black carp by RNA-seq. Overall, a total of 5243 terms were enriched in the gene ontology (GO) analysis, and 323 related pathways were found in the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. A total of 1935 differentially expressed genes were found and were primarily involved in cell adhesion, pathogen recognition, cellular immunity, cytokines, complement systems, and iron transport. Sixteen of the differently expressed genes involved in the immune response and the accuracy of the transcriptome data were further validated by quantitative real-time PCR (qRT-PCR). We observed Tissue sections of the spleen infected with A. hydrophila and the control group and found that the spleen of the infecte...
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POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project
AbstractAllergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health). It will use a freely-existing application for AR monitoring that has been tested in 23 countries (theAllergy Diary, iOS and Android, 17,000 users, TLR8). The Allergy Diary will be combined with a new tool allowing queries on allergen, pollen (TLR2), sleep quality and disorders (TRL2) as well as existing longitudinal and geolocalized pollution data. Machine learning will be used to assess the relationship between air pollution, sleep and AR comparing polluted and non-polluted ar...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OrtrJi
Molecular characterization and functional analysis of IL-12p40 from Chinese sea bass (Lateolabrax maculatus) under biotic and abiotic stresses
Publication date: Available online 15 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Xiang Chen, Pengfei Wang, Chao Zhao, Lulu Yan, Heizhao Lin, Lihua QiuAbstractInterleukins are critical cytokines that are ubiquitously present in both vertebrates and invertebrates and constitute the front line of host innate immunity. Here, we identified and analyzed IL-12p40 from the Chinese sea bass Lateolabrax maculatus (LmIL-12p40). The LmIL-12p40 gene is expressed as a 1386-base pair transcript that encodes a polypeptide of 321 amino acids. Transcriptional expression analysis indicated that LmIL-12p40 mRNA was ubiquitously expressed in all tested tissues and had a comparatively high expression level in immune-associated tissues (head-kidney and intestines). Quantitative reverse-transcrip...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ng4CU5
Physiopathological responses of sole (Solea senegalensis) subjected to bacterial infection and handling stress after probiotic treatment with autochthonous bacteria
This study aimed to evaluate the protective effects of four autochthonous bacteria isolated from juvenile sole (Solea senegalensis) intestine as dietary probiotic supplement against bacterial pathogen infection and handling/transport stressors. Growth performance and immune responses were evaluated after 85 days of feeding trial. Sole (IBW = 16.07 ± 0.11 g) were fed six experimental diets, a control diet (CTRL, without the dietary probiotic supplementation), and five diets supplemented with probiotic bacteria: PB1 (Shewanella hafniensis), PB2 (Enterococcus raffinosus), PB3 (Shewanella hafniensis + Arthrobacter soli), PB4 (Pseudomonas protegens + Arthrobacter soli) and PB5 (Shewanella hafniensis + Arthrobacter soli + Enterococcus raffinosus). All bacteria were selected ba...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OqEzGj
Ontogeny of lymphoid organs and mucosal associated lymphoid tissues in meagre (Argyrosomus regius)
This study investigates the development of lymphoid organs and mucosal tissues in larval and juvenile meagre, Argyrosomus regius. For this purpose, meagre larvae were reared from hatch to the juvenile stage, under mesocosm conditions at 18–19 °C, using standard feeding sequences with live prey and artificial food. The kidney was evident upon hatch and included a visible pronephros, with undifferentiated stem cells and excretory tubules at 1 dph (3.15 ± 0.1 mm SL). The thymus was first detected 8 dph (4.49 ± 0.39 mm SL) and was clearly visible 12 dph (5.69 ± 0.76 mm SL), 33 dph (15.69 ± 1.81 mm SL) an outer thymocytic zone and inner epithelial zone were visible. The spleen was present 12 dph, located between exocrine pancreas and intestine and by 26 dph (11....
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OrsYH2
Transcriptome analysis and histopathology of black carp (Mylopharyngodon piceus) spleen infected by Aeromonas hydrophila
In this study, we analyzed the spleen of disease-resistant and susceptible black carp by RNA-seq. Overall, a total of 5243 terms were enriched in the gene ontology (GO) analysis, and 323 related pathways were found in the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. A total of 1935 differentially expressed genes were found and were primarily involved in cell adhesion, pathogen recognition, cellular immunity, cytokines, complement systems, and iron transport. Sixteen of the differently expressed genes involved in the immune response and the accuracy of the transcriptome data were further validated by quantitative real-time PCR (qRT-PCR). We observed Tissue sections of the spleen infected with A. hydrophila and the control group and found that the spleen of the infecte...
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Woman battling cancer to receive bone marrow transplant from her 14-year-old daughter
| Woman battling cancer to receive bone marrow transplant from her 14-year-old daughter FOX10 NewsFull coverage |
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Woman battling cancer to receive bone marrow transplant from her 14-year-old daughter
| Woman battling cancer to receive bone marrow transplant from her 14-year-old daughter FOX10 NewsFull coverage |
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Scientists map interactions between head and neck cancer and HPV virus
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Scientists map interactions between head and neck cancer and HPV virus
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Promyelocytic leukemia zinc finger triggers ATP-binding cassette subfamily E member 1-mediated growth inhibition in breast cancer cells.
Authors: Suliman BA, Al-Yahya S Abstract The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor that is involved in a number of biological processes, including those regulating cellular growth; however, little is known regarding how it achieves its inhibitory effect in different cell and tissue types. It has previously been demonstrated that PLZF expression levels become diminished during the oncogenic transformation of certain tissue types and thus, may serve as a hallmark for tumor aggressiveness. To examine this in breast cancer, survival curves from available oncology databases were analyzed and demonstrated that PLZF expression was positively associated with increased survival in patients with breast cancer. The mRNA and protein levels of PLZF were als...
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Promyelocytic leukemia zinc finger triggers ATP-binding cassette subfamily E member 1-mediated growth inhibition in breast cancer cells.
Authors: Suliman BA, Al-Yahya S Abstract The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor that is involved in a number of biological processes, including those regulating cellular growth; however, little is known regarding how it achieves its inhibitory effect in different cell and tissue types. It has previously been demonstrated that PLZF expression levels become diminished during the oncogenic transformation of certain tissue types and thus, may serve as a hallmark for tumor aggressiveness. To examine this in breast cancer, survival curves from available oncology databases were analyzed and demonstrated that PLZF expression was positively associated with increased survival in patients with breast cancer. The mRNA and protein levels of PLZF were als...
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Polymorphisms in P53 and VEGFA genes in different subtypes of periorbital hyperpigmentation in a Malaysian Chinese population.
CONCLUSION: Mixed subtype was the most prevalent type of periorbital hyperpigmentation in the study population. Three polymorphisms in p53 and VEGFA genes were statistically linked with different clinical presentations of periorbital hyperpigmentation. PMID: 30215845 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
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Polymorphisms in P53 and VEGFA genes in different subtypes of periorbital hyperpigmentation in a Malaysian Chinese population.
CONCLUSION: Mixed subtype was the most prevalent type of periorbital hyperpigmentation in the study population. Three polymorphisms in p53 and VEGFA genes were statistically linked with different clinical presentations of periorbital hyperpigmentation. PMID: 30215845 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
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Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...
| Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ... TokeNexaFull coverage |
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Follicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025
| Follicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025 Redfield Herald (press release) (blog)Full coverage |
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Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...
| Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ... TokeNexaFull coverage |
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Follicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025
| Follicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025 Redfield Herald (press release) (blog)Full coverage |
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Protective effect of N-acetylcysteine against cisplatin ototoxicity in rats: a study with hearing tests and scanning electron microscopy
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Protective effect of N-acetylcysteine against cisplatin ototoxicity in rats: a study with hearing tests and scanning electron microscopy
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Allergic reactions in oral and perioral diseases—what do allergy skin test results show?
ConclusionsAllergy skin tests are reliable and justified for diagnosing allergies in cases of persistent or recurrent oral diseases. This is the only way to confirm allergies and is the basis for consequent allergen avoidance for the benefit of the patient. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
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Screening the full leukocyte receptor complex (LRC) region revealed associations with pemphigus that might be explained by gene regulation.
This article is protected by copyright. All rights reserved. PMID: 30216441 [PubMed - as supplied by publisher] (Source: Immunology)
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Allergic reactions in oral and perioral diseases—what do allergy skin test results show?
ConclusionsAllergy skin tests are reliable and justified for diagnosing allergies in cases of persistent or recurrent oral diseases. This is the only way to confirm allergies and is the basis for consequent allergen avoidance for the benefit of the patient. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
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Screening the full leukocyte receptor complex (LRC) region revealed associations with pemphigus that might be explained by gene regulation.
This article is protected by copyright. All rights reserved. PMID: 30216441 [PubMed - as supplied by publisher] (Source: Immunology)
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Insights into adsorption behaviour of binary liquid mixtures in porous media using fast field cycling NMR
Publication date: Available online 16 September 2018
Source: Magnetic Resonance Imaging
Author(s): J. Ward-Williams, L.F. Gladden
Abstract
Fast field cycling, FFC, NMR relaxometry experiments are reported in the frequency range of 10 kHz–40 MHz to characterise the adsorption behaviour of cyclohexane:THF (non-polar:polar) and THF:methanol (polar:polar) binary liquid mixtures adsorbed on a γ-alumina surface of catalytic interest. Laplace inversion of the relaxation rate data is employed to identify the chemical species in the binary mixture. In both systems studied, the more polar molecule preferentially interacts with the surface compared to the co-imbibed species. The relaxation rate data were analysed to explore the relative influences of surface dynamics and surface accessibility on the observed relaxation rates. For both binary systems, the change in relaxation behaviour with composition is interpreted as a change in the surface accessibility of each species caused by a micro-phase separation at the pore surface.
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Fast spatially-resolved T2 measurements with constant-gradient CPMG
Publication date: Available online 15 September 2018
Source: Magnetic Resonance Imaging
Author(s): Stefan A. Hertel, Daan W. de Kort, Isabelle Bush, Andrew J. Sederman, Lynn F. Gladden, Benjamin Anger, Hilko de Jong, Matthias Appel
Abstract
Speed of acquisition is paramount for the application of magnetic resonance to flow experiments through porous rocks. One popular method for imaging core floods is the spatially resolved T2 experiment which can separate fluids either by their viscosity contrast or by doping one fluid with a relaxation agent. Existing techniques for spatial-T2 may suffer from long acquisition times and eddy currents due to the pulsing of magnetic field gradients. Here, we propose a constant gradient method for 1d spatially-resolved T2 which embraces the speed of frequency encoding techniques and avoids eddy currents by the absence of any gradient ramps during the radio frequency (r.f.) pulse train. We provide the operating envelope for this kind of experiment, which is restricted due to the slice selectivity of the r.f. pulses in the presence of the magnetic field gradient. Additionally, we show that the effects of self-diffusion and the mixing of T1 and T2 contributions are manageable. As an illustration, we have applied this technique to an enhanced oil recovery experiment. The two fluid phases were tracked without any doping and with a time resolution of 40 s. In this case, the increased time resolution allowed us to observe dynamic flow phenomena such as fluid fingering and the calculation of the velocity of the fluid displacement fronts.
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Insights into adsorption behaviour of binary liquid mixtures in porous media using fast field cycling NMR
Publication date: Available online 16 September 2018
Source: Magnetic Resonance Imaging
Author(s): J. Ward-Williams, L.F. Gladden
Abstract
Fast field cycling, FFC, NMR relaxometry experiments are reported in the frequency range of 10 kHz–40 MHz to characterise the adsorption behaviour of cyclohexane:THF (non-polar:polar) and THF:methanol (polar:polar) binary liquid mixtures adsorbed on a γ-alumina surface of catalytic interest. Laplace inversion of the relaxation rate data is employed to identify the chemical species in the binary mixture. In both systems studied, the more polar molecule preferentially interacts with the surface compared to the co-imbibed species. The relaxation rate data were analysed to explore the relative influences of surface dynamics and surface accessibility on the observed relaxation rates. For both binary systems, the change in relaxation behaviour with composition is interpreted as a change in the surface accessibility of each species caused by a micro-phase separation at the pore surface.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2D3ue1O
Fast spatially-resolved T2 measurements with constant-gradient CPMG
Publication date: Available online 15 September 2018
Source: Magnetic Resonance Imaging
Author(s): Stefan A. Hertel, Daan W. de Kort, Isabelle Bush, Andrew J. Sederman, Lynn F. Gladden, Benjamin Anger, Hilko de Jong, Matthias Appel
Abstract
Speed of acquisition is paramount for the application of magnetic resonance to flow experiments through porous rocks. One popular method for imaging core floods is the spatially resolved T2 experiment which can separate fluids either by their viscosity contrast or by doping one fluid with a relaxation agent. Existing techniques for spatial-T2 may suffer from long acquisition times and eddy currents due to the pulsing of magnetic field gradients. Here, we propose a constant gradient method for 1d spatially-resolved T2 which embraces the speed of frequency encoding techniques and avoids eddy currents by the absence of any gradient ramps during the radio frequency (r.f.) pulse train. We provide the operating envelope for this kind of experiment, which is restricted due to the slice selectivity of the r.f. pulses in the presence of the magnetic field gradient. Additionally, we show that the effects of self-diffusion and the mixing of T1 and T2 contributions are manageable. As an illustration, we have applied this technique to an enhanced oil recovery experiment. The two fluid phases were tracked without any doping and with a time resolution of 40 s. In this case, the increased time resolution allowed us to observe dynamic flow phenomena such as fluid fingering and the calculation of the velocity of the fluid displacement fronts.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NLRohq
TMP778, a selective inhibitor of ROR γt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
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A hyperactive mutant of Interferon ‐Regulatory‐Factor 4
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
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Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor
Clinical&Experimental Allergy,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Allergy)
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TMP778, a selective inhibitor of ROR γt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations.
This article is protected by copyright. All rights reserved. PMID: 30218573 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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A hyperactive mutant of Interferon-Regulatory-Factor 4.
Authors: Kang CH, Hartmann E, Menke L, Staudenraus D, Abass EF, Raifer H, Porapu A, Camara B, Brüstle A, Pinkenburg O, Bieringer M, Lohoff M Abstract IRFs are a family of transcription factors with pleiotropic functions in immune cells, including in generation of subsets of DCs and macrophages and B cell maturation [1]. IRF1 deficiency results in strongly diminished Th1 responses [2] and an inability to counteract pro-asthmatic Th9 responses [3]. PMID: 30218581 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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Prophylactic treatment against GM-CSF, but not IL-17, abolishes relapses in a chronic murine model of multiple sclerosis.
This article is protected by copyright. All rights reserved. PMID: 30216414 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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TMP778, a selective inhibitor of ROR γt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MBCHJl
A hyperactive mutant of Interferon ‐Regulatory‐Factor 4
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
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Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor
Clinical&Experimental Allergy,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Allergy)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MCKvdx
TMP778, a selective inhibitor of ROR γt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations.
This article is protected by copyright. All rights reserved. PMID: 30218573 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NPydmO
A hyperactive mutant of Interferon-Regulatory-Factor 4.
Authors: Kang CH, Hartmann E, Menke L, Staudenraus D, Abass EF, Raifer H, Porapu A, Camara B, Brüstle A, Pinkenburg O, Bieringer M, Lohoff M Abstract IRFs are a family of transcription factors with pleiotropic functions in immune cells, including in generation of subsets of DCs and macrophages and B cell maturation [1]. IRF1 deficiency results in strongly diminished Th1 responses [2] and an inability to counteract pro-asthmatic Th9 responses [3]. PMID: 30218581 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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Prophylactic treatment against GM-CSF, but not IL-17, abolishes relapses in a chronic murine model of multiple sclerosis.
This article is protected by copyright. All rights reserved. PMID: 30216414 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research The Patriot LedgerFull coverage |
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research The Patriot LedgerFull coverage |
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Coping with stress, control of emotions and biochemical markers as a common protective element in the inflammatory response to stress.
CONCLUSIONS: In difficult situations, accompanied by an increase in the variables responsible for the biochemical inflammatory response of an organism, the effective model of coping with difficult situations and emotioncontrol increases, while the subjective level of perceived stress drops. PMID: 30218566 [PubMed - in process] (Source: Psychiatria Polska)
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The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model
In conclusion, this study suggests that GW0742 corrects neurobehavioral dysfunction in BTBR mice which is concurrent with modulation of multiple signaling pathways. (Source: Neurochemistry International)
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Statins influence epithelial expression of the antimicrobial peptide LL-37/hCAP-18 independently of the mevalonate pathway.
This article is protected by copyright. All rights reserved. PMID: 30216432 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for Rheumatoid Arthritis.
This study suggests that the hsa_circ_0044235 in peripheral blood may be a potential biomarker of patients with RA. This article is protected by copyright. All rights reserved. PMID: 30216431 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Clinical & laboratory features of seventy-eight UK patients with Good's syndrome (thymoma & hypogammaglobulinemia).
This article is protected by copyright. All rights reserved. PMID: 30216434 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Coping with stress, control of emotions and biochemical markers as a common protective element in the inflammatory response to stress.
CONCLUSIONS: In difficult situations, accompanied by an increase in the variables responsible for the biochemical inflammatory response of an organism, the effective model of coping with difficult situations and emotioncontrol increases, while the subjective level of perceived stress drops. PMID: 30218566 [PubMed - in process] (Source: Psychiatria Polska)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model
In conclusion, this study suggests that GW0742 corrects neurobehavioral dysfunction in BTBR mice which is concurrent with modulation of multiple signaling pathways. (Source: Neurochemistry International)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xohlti
Statins influence epithelial expression of the antimicrobial peptide LL-37/hCAP-18 independently of the mevalonate pathway.
This article is protected by copyright. All rights reserved. PMID: 30216432 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for Rheumatoid Arthritis.
This study suggests that the hsa_circ_0044235 in peripheral blood may be a potential biomarker of patients with RA. This article is protected by copyright. All rights reserved. PMID: 30216431 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xnL31x
Clinical & laboratory features of seventy-eight UK patients with Good's syndrome (thymoma & hypogammaglobulinemia).
This article is protected by copyright. All rights reserved. PMID: 30216434 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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QUANTITATIVE ASSESSMENT OF PULMONARY VASCULAR ALTERATIONS IN CHRONIC OBSTRUCTIVE LUNG DISEASE: ASSOCIATIONS WITH PULMONARY FUNCTION TEST AND SURVIVAL IN THE KOLD COHORT
Publication date: Available online 15 September 2018
Source: European Journal of Radiology
Author(s): Young Hoon Cho, Sang Min Lee, Joon Beom Seo, Namkug Kim, Jang Pyo Bae, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee
Abstract
Purpose
Despite the high prevalence of pulmonary vascular alterations and their substantial impact on chronic obstructive pulmonary disease (COPD), tools for the direct in vivo assessment of pulmonary vascular alterations remain limited. Thus, the purpose of this study was to automatically extract pulmonary vessels from volumetric chest CT and evaluate the associations between the derived quantitative pulmonary vessel features and clinical parameters, including survival, in COPD patients.
Methods
This study included 344 adult COPD patients. Pulmonary vessels were automatically extracted from volumetric chest CT data. Quantitative pulmonary vessel features were obtained from various lung surface areas (LSAs), which are theoretical surface areas drawn at different depths from the pleural borders. The total number of vessels (Ntotal) and number of vessels with vessel area (VA) less than 5 mm2 (N<5mm) were counted as both robust values and as values per 10 cm2 of LSA (Ntotal/LSA; N<5mm/LSA). The average VA (VAmean) and percentage of measured VA in the corresponding LSA (%VA) were measured. Associations between quantitative pulmonary vessel features and clinical parameters, including survival and the pulmonary function test (PFT), were evaluated.
Results
The pulmonary vessels were automatically extracted with 100% technical success. Cox regression analysis showed Ntotal/LSA, N<5mm/LSA, VAmean, and %VA to be significant predictors of survival (hazard ratio (HR), 0.80, 0.75, 0.70, 0.49, respectively). Patients classified into high-risk groups by %VA18mm (cut-off = 3.258), chosen because it demonstrated the strongest statistical influence on survival in a univariate Cox analysis, were associated with worse overall survival before (HR, 4.83; p < 0.001) and after adjustment for patient age and BMI (HR, 2.18; p = 0.014). Of the quantitative pulmonary vessel features, Ntotal/LSA, N<5mm/LSA, and %VA were correlated with FEV1, FEV1/FVC, and DLCO in all LSAs. The strongest correlation with PFTs was noted at LSA9mm for both Ntotal (FEV1, r = 0.33; FEV1/FVC, r = 0.51) and N<5mm (FEV1, r = 0.35; FEV1/FVC, r = 0.52). For %VA, the association was most evident at LSA18mm (FEV1, r = 0.27; FEV1/FVC, r = 0.47). Significant moderate to strong correlations were consistently observed between the extent of emphysema and quantitative pulmonary vessel features (r = 0.44–0.66; all p < 0.001).
Conclusions
The automated extraction of pulmonary vessels and their quantitative assessment are technically feasible. Various quantitative pulmonary vessel features demonstrated significant relationships with survival and PFT in COPD patients. Of the various quantitative features, the percentage of total VA measured at 18 mm depth from the pleural surface (%VA18mm) and the number of small vessels counted per 10 cm2 of LSA at 9 mm depth from the pleural surface (N<5mm/LSA9mm) had the strongest predictability for the clinical parameters.
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QUANTITATIVE ASSESSMENT OF PULMONARY VASCULAR ALTERATIONS IN CHRONIC OBSTRUCTIVE LUNG DISEASE: ASSOCIATIONS WITH PULMONARY FUNCTION TEST AND SURVIVAL IN THE KOLD COHORT
Publication date: Available online 15 September 2018
Source: European Journal of Radiology
Author(s): Young Hoon Cho, Sang Min Lee, Joon Beom Seo, Namkug Kim, Jang Pyo Bae, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee
Abstract
Purpose
Despite the high prevalence of pulmonary vascular alterations and their substantial impact on chronic obstructive pulmonary disease (COPD), tools for the direct in vivo assessment of pulmonary vascular alterations remain limited. Thus, the purpose of this study was to automatically extract pulmonary vessels from volumetric chest CT and evaluate the associations between the derived quantitative pulmonary vessel features and clinical parameters, including survival, in COPD patients.
Methods
This study included 344 adult COPD patients. Pulmonary vessels were automatically extracted from volumetric chest CT data. Quantitative pulmonary vessel features were obtained from various lung surface areas (LSAs), which are theoretical surface areas drawn at different depths from the pleural borders. The total number of vessels (Ntotal) and number of vessels with vessel area (VA) less than 5 mm2 (N<5mm) were counted as both robust values and as values per 10 cm2 of LSA (Ntotal/LSA; N<5mm/LSA). The average VA (VAmean) and percentage of measured VA in the corresponding LSA (%VA) were measured. Associations between quantitative pulmonary vessel features and clinical parameters, including survival and the pulmonary function test (PFT), were evaluated.
Results
The pulmonary vessels were automatically extracted with 100% technical success. Cox regression analysis showed Ntotal/LSA, N<5mm/LSA, VAmean, and %VA to be significant predictors of survival (hazard ratio (HR), 0.80, 0.75, 0.70, 0.49, respectively). Patients classified into high-risk groups by %VA18mm (cut-off = 3.258), chosen because it demonstrated the strongest statistical influence on survival in a univariate Cox analysis, were associated with worse overall survival before (HR, 4.83; p < 0.001) and after adjustment for patient age and BMI (HR, 2.18; p = 0.014). Of the quantitative pulmonary vessel features, Ntotal/LSA, N<5mm/LSA, and %VA were correlated with FEV1, FEV1/FVC, and DLCO in all LSAs. The strongest correlation with PFTs was noted at LSA9mm for both Ntotal (FEV1, r = 0.33; FEV1/FVC, r = 0.51) and N<5mm (FEV1, r = 0.35; FEV1/FVC, r = 0.52). For %VA, the association was most evident at LSA18mm (FEV1, r = 0.27; FEV1/FVC, r = 0.47). Significant moderate to strong correlations were consistently observed between the extent of emphysema and quantitative pulmonary vessel features (r = 0.44–0.66; all p < 0.001).
Conclusions
The automated extraction of pulmonary vessels and their quantitative assessment are technically feasible. Various quantitative pulmonary vessel features demonstrated significant relationships with survival and PFT in COPD patients. Of the various quantitative features, the percentage of total VA measured at 18 mm depth from the pleural surface (%VA18mm) and the number of small vessels counted per 10 cm2 of LSA at 9 mm depth from the pleural surface (N<5mm/LSA9mm) had the strongest predictability for the clinical parameters.
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Otological surgery in paediatric photosensitive patients
Publication date: Available online 15 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): James Bates, Andy Hall, Thushitha Kunanandam, Richard Hewitt
Abstract
There are a wide range of genetic and auto-immune conditions where UV light exposure poses a threat of UV irradiation to the external auditory canal, tympanic membrane and surrounding skin. Preoperative Ultraviolet Light (UV) measurements were taken in the operating theatre with standard operating microscope and an approved UV light meter prior to surgery on a patient with xeroderma pigmentosa. UV light meter readings of UV index 75 were taken at an operating distance of 290mm. Proceeding with otological surgery with a high UV index would result in a significant UV radiation burn. Utilising a Dermagard and a specific UV filter applied to the microscope resulted in acceptable UV light readings. We highlight the potential morbidity of otological surgery in paediatric photosensitive conditions. We also recommend a management plan to avoid damage by UV radiation in photosensitive patients.
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Otological surgery in paediatric photosensitive patients
Publication date: Available online 15 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): James Bates, Andy Hall, Thushitha Kunanandam, Richard Hewitt
Abstract
There are a wide range of genetic and auto-immune conditions where UV light exposure poses a threat of UV irradiation to the external auditory canal, tympanic membrane and surrounding skin. Preoperative Ultraviolet Light (UV) measurements were taken in the operating theatre with standard operating microscope and an approved UV light meter prior to surgery on a patient with xeroderma pigmentosa. UV light meter readings of UV index 75 were taken at an operating distance of 290mm. Proceeding with otological surgery with a high UV index would result in a significant UV radiation burn. Utilising a Dermagard and a specific UV filter applied to the microscope resulted in acceptable UV light readings. We highlight the potential morbidity of otological surgery in paediatric photosensitive conditions. We also recommend a management plan to avoid damage by UV radiation in photosensitive patients.
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research MetroWest Daily NewsFull coverage |
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The error-related negativity for error processing in interoception
Publication date: Available online 15 September 2018
Source: NeuroImage
Author(s): Yafei Tan, Jolien Vandeput, Jiang Qiu, Omer Van den Bergh, Andreas von Leupoldt
Abstract
The error-related negativity (ERN) is an event-related potential in the electroencephalogram (EEG) observed within the first 100 ms after commission of an error. Increased ERN amplitudes have been observed in several psychological disorders characterized by high negative affect. While the ERN has extensively been studied in tasks using exteroceptive stimuli, its relation to interoceptive stimuli is unknown. Since errors related to interoception might be particularly relevant for survival and negative affect, this study aimed to explore the ERN for errors related to interoceptive, respiratory sensations (intERN). Moreover, we compared the intERN with a commonly observed ERN related to exteroceptive, visual stimuli (extERN) and examined their associations with interoception-related negative affect. We studied the ERN using a respiratory occlusion task (intERN) and a visual flanker task (extERN) in 40 healthy volunteers during continuous 129 channel EEG recordings. In the occlusion task, participants received inspiratory occlusions of two different durations and indicated whether each occlusion was short or long. In the Flanker task, participants indicated the direction of arrowheads. Interoception-related negative affect was assessed with the Anxiety Sensitivity Index. Comparable with the extERN, the intERN was observed at fronto-central scalp positions after error commission in the occlusion task, but it peaked significantly earlier than the extERN. Mean amplitudes of the intERN and extERN showed no significant difference and were not correlated. Moreover, higher levels of anxiety sensitivity were correlated with significantly greater amplitudes of the intERN, but with lower amplitudes of the extERN. The present results firstly demonstrate an error-related negativity EEG-potential that is related to interoceptive sensations (intERN). This intERN is not associated with a commonly observed ERN elicited by exteroceptive stimuli and is distinctly linked to higher levels of interoception-related negative affect. The intERN might be a promising neural marker for future studies on interoception, negative affect and error processing.
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research MetroWest Daily NewsFull coverage |
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The error-related negativity for error processing in interoception
Publication date: Available online 15 September 2018
Source: NeuroImage
Author(s): Yafei Tan, Jolien Vandeput, Jiang Qiu, Omer Van den Bergh, Andreas von Leupoldt
Abstract
The error-related negativity (ERN) is an event-related potential in the electroencephalogram (EEG) observed within the first 100 ms after commission of an error. Increased ERN amplitudes have been observed in several psychological disorders characterized by high negative affect. While the ERN has extensively been studied in tasks using exteroceptive stimuli, its relation to interoceptive stimuli is unknown. Since errors related to interoception might be particularly relevant for survival and negative affect, this study aimed to explore the ERN for errors related to interoceptive, respiratory sensations (intERN). Moreover, we compared the intERN with a commonly observed ERN related to exteroceptive, visual stimuli (extERN) and examined their associations with interoception-related negative affect. We studied the ERN using a respiratory occlusion task (intERN) and a visual flanker task (extERN) in 40 healthy volunteers during continuous 129 channel EEG recordings. In the occlusion task, participants received inspiratory occlusions of two different durations and indicated whether each occlusion was short or long. In the Flanker task, participants indicated the direction of arrowheads. Interoception-related negative affect was assessed with the Anxiety Sensitivity Index. Comparable with the extERN, the intERN was observed at fronto-central scalp positions after error commission in the occlusion task, but it peaked significantly earlier than the extERN. Mean amplitudes of the intERN and extERN showed no significant difference and were not correlated. Moreover, higher levels of anxiety sensitivity were correlated with significantly greater amplitudes of the intERN, but with lower amplitudes of the extERN. The present results firstly demonstrate an error-related negativity EEG-potential that is related to interoceptive sensations (intERN). This intERN is not associated with a commonly observed ERN elicited by exteroceptive stimuli and is distinctly linked to higher levels of interoception-related negative affect. The intERN might be a promising neural marker for future studies on interoception, negative affect and error processing.
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Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
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FDA to review application to modify health warning on Altria subsidiary’s smokeless tobacco product
Source: www.richmond.com Author: staff The U.S. Food and Drug Administration will review a request from an Altria Group Inc. subsidiary that […]
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Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
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FDA to review application to modify health warning on Altria subsidiary’s smokeless tobacco product
Source: www.richmond.com Author: staff The U.S. Food and Drug Administration will review a request from an Altria Group Inc. subsidiary that […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OtzRaU
Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
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FDA to review application to modify health warning on Altria subsidiary’s smokeless tobacco product
Source: www.richmond.com Author: staff The U.S. Food and Drug Administration will review a request from an Altria Group Inc. subsidiary that […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OtzRaU
Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NfDTah
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