Surface-type chondromyxoid fibroma in an elderly patient: a case report and literature review

Abstract

Chondromyxoid fibroma (CMF) is a rare benign bone neoplasm that typically occurs in young adults. Juxtacortical or surface-type CMF are rarer still and we present the case of a surface-type CMF in a 78-year-old woman, with only one other case described in a patient of a similar age previously. This patient was an otherwise healthy woman who presented for evaluation of a palpable lump in the anterior proximal tibia. Initial radiographs obtained demonstrated a focal soft tissue fullness immediately anterior to the anterior cortex of the proximal tibia, which contained faint chondroid-like matrix internally. There was associated scalloping of the anterior tibial cortex. MRI confirmed the presence of a juxtacortical, enhancing lesion. Subsequent excisional biopsy was performed and histopathology demonstrated features, which was consistent with surface-type CMF. At a 6-month follow-up the patient remained free of recurrence. In a patient of this age, paraosteal chondrosarcoma should be excluded. Surface-type CMF, although rare, has been described in older patients and while it is unlikely to feature in a list of differential considerations on initial imaging, awareness of the entity is important.

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Speaker Gender Representation at the American Society of Anesthesiology Annual Meeting: 2011–2016

The American Society of Anesthesiologists (ASA) Annual Meeting is the primary venue for anesthesiologists to present research, share innovations, and build networks. Herein, we describe gender representation for physician speakers at the Annual Meeting relative to the specialty overall. Details of ASA Annual Meeting presentations for individuals and panels were abstracted from the ASA archives for 2011–2016. Observed speaker gender composition was compared to expected composition based on the gender distribution of members of the ASA. There were 5167 speaker slots across 2025 presentations and panels. Of the speaker slots, 3874 were assigned to men and 1293 to women. Speaker slot gender composition was relatively consistent between 2011 and 2016 (annual percentage 22.3%–27.7% women, trend test P = .062). ASA membership composition of women increased slightly over the study period (24%–28%). The overall observed number of women in speaker slots over the study period did not differ significantly from what would be expected based on the ASA membership composition (25.0% observed vs 25.9% expected; P = .153). However, the percentage of single speakers who were women was significantly less than would be expected based on the ASA gender distribution (20.2% observed vs 25.9% expected; P

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Handbook of Sepsis

No abstract available

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The Impact of Postoperative Intensive Care Unit Admission on Postoperative Hospital Length of Stay and Costs: A Prespecified Propensity-Matched Cohort Study

BACKGROUND: In this prespecified cohort study, we investigated the influence of postoperative admission to the intensive care unit versus surgical ward on health care utilization among patients undergoing intermediate-risk surgery. METHODS: Of adult surgical patients who underwent general anesthesia without an absolute indication for postoperative intensive care unit admission, 3530 patients admitted postoperatively to an intensive care unit were matched to 3530 patients admitted postoperatively to a surgical ward using a propensity score based on 23 important preoperative and intraoperative predictor variables. Postoperative hospital length of stay and hospital costs were defined as primary and secondary end points, respectively. RESULTS: Among patients with low propensity for postoperative intensive care unit admission, initial triage to an intensive care unit was associated with increased postoperative length of stay (incidence rate ratio, 1.69 [95% CI, 1.59–1.79]; P

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Speaker Gender Representation at the American Society of Anesthesiology Annual Meeting: 2011–2016

The American Society of Anesthesiologists (ASA) Annual Meeting is the primary venue for anesthesiologists to present research, share innovations, and build networks. Herein, we describe gender representation for physician speakers at the Annual Meeting relative to the specialty overall. Details of ASA Annual Meeting presentations for individuals and panels were abstracted from the ASA archives for 2011–2016. Observed speaker gender composition was compared to expected composition based on the gender distribution of members of the ASA. There were 5167 speaker slots across 2025 presentations and panels. Of the speaker slots, 3874 were assigned to men and 1293 to women. Speaker slot gender composition was relatively consistent between 2011 and 2016 (annual percentage 22.3%–27.7% women, trend test P = .062). ASA membership composition of women increased slightly over the study period (24%–28%). The overall observed number of women in speaker slots over the study period did not differ significantly from what would be expected based on the ASA membership composition (25.0% observed vs 25.9% expected; P = .153). However, the percentage of single speakers who were women was significantly less than would be expected based on the ASA gender distribution (20.2% observed vs 25.9% expected; P

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Journal Article Reviews

No abstract available

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Does the Current American Society of Anesthesiologists Physical Status Classification Represent the Chronic Disease Burden in Children Undergoing General Anesthesia?

No abstract available

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Pain Management: A Problem-Based Learning Approach

No abstract available

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Pain Management: A Problem-Based Learning Approach

No abstract available

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A Comparison of Spinal Anesthesia Versus Monitored Anesthesia Care With Local Anesthesia in Minimally Invasive Fetal Surgery

BACKGROUND: Minimally invasive fetal surgery is commonly performed to treat twin-to-twin transfusion syndrome with selective fetoscopic laser photocoagulation and twin-reversed arterial perfusion sequence using radiofrequency ablation. Although an increasing number of centers worldwide are performing these procedures, anesthetic management varies. Both neuraxial anesthesia and monitored anesthesia care with local anesthesia are used at different institutions. We sought to determine the efficacy and outcomes of these 2 anesthetic techniques for fetal procedures at our institution. METHODS: All patients undergoing minimally invasive fetal surgery for twin-to-twin transfusion syndrome or twin-reversed arterial perfusion sequence over a 6-year time period (2011–2016) were reviewed. Patients receiving monitored anesthesia care with local anesthesia were compared with those receiving spinal anesthesia in both selective fetoscopic laser photocoagulation and radiofrequency ablation fetal procedures. The primary outcome examined between the monitored anesthesia care and spinal anesthesia groups was the difference in conversion to general anesthesia using a noninferiority design with a noninferiority margin of 5%. Secondary outcome measures included use of vasopressors, procedure times, intraoperative fluids administered, maternal complications, and unexpected fetal demise within 24 hours of surgery. RESULTS: The difference in failure rate between monitored anesthesia care and spinal was −0.5% (95% CI, −4.8% to 3.7%). Patients receiving monitored anesthesia care plus local anesthesia were significantly less likely to need vasopressors, had a shorter presurgical operating room time, and received less fluid (P

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A Comparison of Spinal Anesthesia Versus Monitored Anesthesia Care With Local Anesthesia in Minimally Invasive Fetal Surgery

BACKGROUND: Minimally invasive fetal surgery is commonly performed to treat twin-to-twin transfusion syndrome with selective fetoscopic laser photocoagulation and twin-reversed arterial perfusion sequence using radiofrequency ablation. Although an increasing number of centers worldwide are performing these procedures, anesthetic management varies. Both neuraxial anesthesia and monitored anesthesia care with local anesthesia are used at different institutions. We sought to determine the efficacy and outcomes of these 2 anesthetic techniques for fetal procedures at our institution. METHODS: All patients undergoing minimally invasive fetal surgery for twin-to-twin transfusion syndrome or twin-reversed arterial perfusion sequence over a 6-year time period (2011–2016) were reviewed. Patients receiving monitored anesthesia care with local anesthesia were compared with those receiving spinal anesthesia in both selective fetoscopic laser photocoagulation and radiofrequency ablation fetal procedures. The primary outcome examined between the monitored anesthesia care and spinal anesthesia groups was the difference in conversion to general anesthesia using a noninferiority design with a noninferiority margin of 5%. Secondary outcome measures included use of vasopressors, procedure times, intraoperative fluids administered, maternal complications, and unexpected fetal demise within 24 hours of surgery. RESULTS: The difference in failure rate between monitored anesthesia care and spinal was −0.5% (95% CI, −4.8% to 3.7%). Patients receiving monitored anesthesia care plus local anesthesia were significantly less likely to need vasopressors, had a shorter presurgical operating room time, and received less fluid (P

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The Impact of Postoperative Intensive Care Unit Admission on Postoperative Hospital Length of Stay and Costs: A Prespecified Propensity-Matched Cohort Study

BACKGROUND: In this prespecified cohort study, we investigated the influence of postoperative admission to the intensive care unit versus surgical ward on health care utilization among patients undergoing intermediate-risk surgery. METHODS: Of adult surgical patients who underwent general anesthesia without an absolute indication for postoperative intensive care unit admission, 3530 patients admitted postoperatively to an intensive care unit were matched to 3530 patients admitted postoperatively to a surgical ward using a propensity score based on 23 important preoperative and intraoperative predictor variables. Postoperative hospital length of stay and hospital costs were defined as primary and secondary end points, respectively. RESULTS: Among patients with low propensity for postoperative intensive care unit admission, initial triage to an intensive care unit was associated with increased postoperative length of stay (incidence rate ratio, 1.69 [95% CI, 1.59–1.79]; P

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General Anesthesia Alters the Diversity and Composition of the Intestinal Microbiota in Mice

Dysbiosis of the intestinal microbiota has been shown to result in altered immune responses and increased susceptibility to infection; as such, the state of the intestinal microbiome may have profound implications in the perioperative setting. In this first-in-class study, we used 16s ribosomal RNA sequencing and analysis in a mouse model of general anesthesia to investigate the effects of volatile anesthetics on the diversity and composition of the intestinal microbiome. After 4-hour exposure to isoflurane, we observed a decrease in bacterial diversity. Taxonomic alterations included depletion of several commensal bacteria including Clostridiales. These data identify volatile anesthetics as potential contributors to microbial dysbiosis in the postoperative patient. Accepted for publication October 17, 2018. Funding:This work was supported by grants from the National Institutes of Health (R01 GM120519-01). The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). Reprints will not be available from the authors. Address correspondence to Cyrus D. Mintz, MD, PhD, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Bldg 370, Baltimore, MD 21205. Address e-mail to Cmintz2@jhmi.edu. © 2018 International Anesthesia Research Society

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Remote Surveillance Technologies: Realizing the Aim of Right Patient, Right Data, Right Time

The convergence of multiple recent developments in health care information technology and monitoring devices has made possible the creation of remote patient surveillance systems that increase the timeliness and quality of patient care. More convenient, less invasive monitoring devices, including patches, wearables, and biosensors, now allow for continuous physiological data to be gleaned from patients in a variety of care settings across the perioperative experience. These data can be bound into a single data repository, creating so-called data lakes. The high volume and diversity of data in these repositories must be processed into standard formats that can be queried in real time. These data can then be used by sophisticated prediction algorithms currently under development, enabling the early recognition of patterns of clinical deterioration otherwise undetectable to humans. Improved predictions can reduce alarm fatigue. In addition, data are now automatically queriable on a real-time basis such that they can be fed back to clinicians in a time frame that allows for meaningful intervention. These advancements are key components of successful remote surveillance systems. Anesthesiologists have the opportunity to be at the forefront of remote surveillance in the care they provide in the operating room, postanesthesia care unit, and intensive care unit, while also expanding their scope to include high-risk preoperative and postoperative patients on the general care wards. These systems hold the promise of enabling anesthesiologists to detect and intervene upon changes in the clinical status of the patient before adverse events have occurred. Importantly, however, significant barriers still exist to the effective deployment of these technologies and their study in impacting patient outcomes. Studies demonstrating the impact of remote surveillance on patient outcomes are limited. Critical to the impact of the technology are strategies of implementation, including who should receive and respond to alerts and how they should respond. Moreover, the lack of cost-effectiveness data and the uncertainty of whether clinical activities surrounding these technologies will be financially reimbursed remain significant challenges to future scale and sustainability. This narrative review will discuss the evolving technical components of remote surveillance systems, the clinical use cases relevant to the anesthesiologist's practice, the existing evidence for their impact on patients, the barriers that exist to their effective implementation and study, and important considerations regarding sustainability and cost-effectiveness. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Accepted for publication October 18, 2018. Funding: None. The authors declare no conflicts of interest. Reprints will not be available from the authors. Address correspondence to Jeanine P. Wiener-Kronish, MD, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 55 Fruit St, GRB 4–444, Boston, MA 02114. Address e-mail to jwiener-kronish@partners.org. © 2018 International Anesthesia Research Society

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General Anesthesia Alters the Diversity and Composition of the Intestinal Microbiota in Mice

Dysbiosis of the intestinal microbiota has been shown to result in altered immune responses and increased susceptibility to infection; as such, the state of the intestinal microbiome may have profound implications in the perioperative setting. In this first-in-class study, we used 16s ribosomal RNA sequencing and analysis in a mouse model of general anesthesia to investigate the effects of volatile anesthetics on the diversity and composition of the intestinal microbiome. After 4-hour exposure to isoflurane, we observed a decrease in bacterial diversity. Taxonomic alterations included depletion of several commensal bacteria including Clostridiales. These data identify volatile anesthetics as potential contributors to microbial dysbiosis in the postoperative patient. Accepted for publication October 17, 2018. Funding:This work was supported by grants from the National Institutes of Health (R01 GM120519-01). The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). Reprints will not be available from the authors. Address correspondence to Cyrus D. Mintz, MD, PhD, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Bldg 370, Baltimore, MD 21205. Address e-mail to Cmintz2@jhmi.edu. © 2018 International Anesthesia Research Society

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Remote Surveillance Technologies: Realizing the Aim of Right Patient, Right Data, Right Time

The convergence of multiple recent developments in health care information technology and monitoring devices has made possible the creation of remote patient surveillance systems that increase the timeliness and quality of patient care. More convenient, less invasive monitoring devices, including patches, wearables, and biosensors, now allow for continuous physiological data to be gleaned from patients in a variety of care settings across the perioperative experience. These data can be bound into a single data repository, creating so-called data lakes. The high volume and diversity of data in these repositories must be processed into standard formats that can be queried in real time. These data can then be used by sophisticated prediction algorithms currently under development, enabling the early recognition of patterns of clinical deterioration otherwise undetectable to humans. Improved predictions can reduce alarm fatigue. In addition, data are now automatically queriable on a real-time basis such that they can be fed back to clinicians in a time frame that allows for meaningful intervention. These advancements are key components of successful remote surveillance systems. Anesthesiologists have the opportunity to be at the forefront of remote surveillance in the care they provide in the operating room, postanesthesia care unit, and intensive care unit, while also expanding their scope to include high-risk preoperative and postoperative patients on the general care wards. These systems hold the promise of enabling anesthesiologists to detect and intervene upon changes in the clinical status of the patient before adverse events have occurred. Importantly, however, significant barriers still exist to the effective deployment of these technologies and their study in impacting patient outcomes. Studies demonstrating the impact of remote surveillance on patient outcomes are limited. Critical to the impact of the technology are strategies of implementation, including who should receive and respond to alerts and how they should respond. Moreover, the lack of cost-effectiveness data and the uncertainty of whether clinical activities surrounding these technologies will be financially reimbursed remain significant challenges to future scale and sustainability. This narrative review will discuss the evolving technical components of remote surveillance systems, the clinical use cases relevant to the anesthesiologist's practice, the existing evidence for their impact on patients, the barriers that exist to their effective implementation and study, and important considerations regarding sustainability and cost-effectiveness. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Accepted for publication October 18, 2018. Funding: None. The authors declare no conflicts of interest. Reprints will not be available from the authors. Address correspondence to Jeanine P. Wiener-Kronish, MD, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 55 Fruit St, GRB 4–444, Boston, MA 02114. Address e-mail to jwiener-kronish@partners.org. © 2018 International Anesthesia Research Society

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Xerotic Eruption and Purpura: Challenge

No abstract available

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Xerotic Eruption and Purpura: Challenge

No abstract available

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Bleeding Umbilical Papule: Challenge

No abstract available

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Bleeding Umbilical Papule: Challenge

No abstract available

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10 Tips for Getting Kids to Go Low Tech This Holiday Season

Do you feel as if sounds of ringtones, alerts and push notifications replace those of sleigh bells, music and crackling fires during today's holidays? Most likely, families of your patients, clients or students feel the same. For audiologists and speech-language pathologists craving a lower-tech holiday season professionally and personally, share these 10 tips to make this goal a reality and help families instead embrace conversation, communication and bonding this holiday season. As always, children who use low- and high-tech augmentative and alternative communication devices (AAC) should continue to use them at all times—and in an interactive way. Editor's note: Also enjoy this non-tech holiday gift guide to help kids reduce screen time.  Here are some screen-reduction tips,...

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10 Tips for Getting Kids to Go Low Tech This Holiday Season

Do you feel as if sounds of ringtones, alerts and push notifications replace those of sleigh bells, music and crackling fires during today's holidays? Most likely, families of your patients, clients or students feel the same. For audiologists and speech-language pathologists craving a lower-tech holiday season professionally and personally, share these 10 tips to make this goal a reality and help families instead embrace conversation, communication and bonding this holiday season. As always, children who use low- and high-tech augmentative and alternative communication devices (AAC) should continue to use them at all times—and in an interactive way. Editor's note: Also enjoy this non-tech holiday gift guide to help kids reduce screen time.  Here are some screen-reduction tips,...

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Use of surgical sealant in the prevention of pharyngocutaneous fistula after total laryngectomy

Abstract

Background

Pharyngocutaneous fistula is a major wound complication of total laryngectomy. Surgical sealants may be used to increase the strength and/or integrity of surgical repairs. The purpose of this study was to present our evaluation of the feasibility and utility of the application of sealant to the pharyngeal repair with the aim of reducing pharyngocutaneous fistula incidence.

Methods

This was a prospective single‐blind randomized controlled study; patients undergoing primary total laryngectomy for advanced carcinoma of the larynx were randomized into control and treatment (albumin‐polyaldehyde sealant applied to pharyngeal repair) groups. Relevant patient, disease, and management‐related factors were recorded.

Results

Forty‐five patients were included (23 controls and 22 who received treatments). No difference in the incidence of pharyngocutaneous fistula was observed between the 2 groups. No treatment‐related complications occurred.

Conclusion

Feasibility of application of an albumin‐polyaldehyde surgical sealant to the pharyngeal repair was demonstrated, however, a pharyngocutaneous fistula‐preventative effect was not observed. Larger animal and clinical studies are encouraged to clarify this finding.

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Use of surgical sealant in the prevention of pharyngocutaneous fistula after total laryngectomy

Abstract

Background

Pharyngocutaneous fistula is a major wound complication of total laryngectomy. Surgical sealants may be used to increase the strength and/or integrity of surgical repairs. The purpose of this study was to present our evaluation of the feasibility and utility of the application of sealant to the pharyngeal repair with the aim of reducing pharyngocutaneous fistula incidence.

Methods

This was a prospective single‐blind randomized controlled study; patients undergoing primary total laryngectomy for advanced carcinoma of the larynx were randomized into control and treatment (albumin‐polyaldehyde sealant applied to pharyngeal repair) groups. Relevant patient, disease, and management‐related factors were recorded.

Results

Forty‐five patients were included (23 controls and 22 who received treatments). No difference in the incidence of pharyngocutaneous fistula was observed between the 2 groups. No treatment‐related complications occurred.

Conclusion

Feasibility of application of an albumin‐polyaldehyde surgical sealant to the pharyngeal repair was demonstrated, however, a pharyngocutaneous fistula‐preventative effect was not observed. Larger animal and clinical studies are encouraged to clarify this finding.

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10 Tips for Getting Kids to Go Low Tech This Holiday Season

Do you feel as if sounds of ringtones, alerts and push notifications replace those of sleigh bells, music and crackling fires during today's holidays? Most likely, families of your patients, clients or students feel the same. For audiologists and speech-language pathologists craving a lower-tech holiday season professionally and personally, share these 10 tips to make this goal a reality and help families instead embrace conversation, communication and bonding this holiday season. As always, children who use low- and high-tech augmentative and alternative communication devices (AAC) should continue to use them at all times—and in an interactive way. Editor's note: Also enjoy this non-tech holiday gift guide to help kids reduce screen time.  Here are some screen-reduction tips,...

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3 Steps to Reduce Stress Over the Things You Can ’ t Change

Being an audiologist or speech-language pathologist can be incredibly rewarding. As clinicians, we get to help people communicate better, safely enjoy their food again, hear their parents or grandchildren, and generally thrive in their lives. Our work can also cause stress and feel overwhelming at times. And those stressful moments often come from factors out of our control, such as demands from paperwork, productivity and growing caseloads. Sometimes stress even comes from a patient or client not achieving desired outcomes or making progress at the rate we expected, causing us to wonder what we can do better. These stresses can be enough to make you feel drained, mentally exhausted and constantly worried about your work. When those stressful moments seem to override positive moments, burn...

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10 Tips for Getting Kids to Go Low Tech This Holiday Season

Do you feel as if sounds of ringtones, alerts and push notifications replace those of sleigh bells, music and crackling fires during today's holidays? Most likely, families of your patients, clients or students feel the same. For audiologists and speech-language pathologists craving a lower-tech holiday season professionally and personally, share these 10 tips to make this goal a reality and help families instead embrace conversation, communication and bonding this holiday season. As always, children who use low- and high-tech augmentative and alternative communication devices (AAC) should continue to use them at all times—and in an interactive way. Editor's note: Also enjoy this non-tech holiday gift guide to help kids reduce screen time.  Here are some screen-reduction tips,...

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3 Steps to Reduce Stress Over the Things You Can ’ t Change

Being an audiologist or speech-language pathologist can be incredibly rewarding. As clinicians, we get to help people communicate better, safely enjoy their food again, hear their parents or grandchildren, and generally thrive in their lives. Our work can also cause stress and feel overwhelming at times. And those stressful moments often come from factors out of our control, such as demands from paperwork, productivity and growing caseloads. Sometimes stress even comes from a patient or client not achieving desired outcomes or making progress at the rate we expected, causing us to wonder what we can do better. These stresses can be enough to make you feel drained, mentally exhausted and constantly worried about your work. When those stressful moments seem to override positive moments, burn...

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10 Tips for Getting Kids to Go Low Tech This Holiday Season

Do you feel as if sounds of ringtones, alerts and push notifications replace those of sleigh bells, music and crackling fires during today's holidays? Most likely, families of your patients, clients or students feel the same. For audiologists and speech-language pathologists craving a lower-tech holiday season professionally and personally, share these 10 tips to make this goal a reality and help families instead embrace conversation, communication and bonding this holiday season. As always, children who use low- and high-tech augmentative and alternative communication devices (AAC) should continue to use them at all times—and in an interactive way. Editor's note: Also enjoy this non-tech holiday gift guide to help kids reduce screen time.  Here are some screen-reduction tips,...

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10 Tips for Getting Kids to Go Low Tech This Holiday Season

Do you feel as if sounds of ringtones, alerts and push notifications replace those of sleigh bells, music and crackling fires during today's holidays? Most likely, families of your patients, clients or students feel the same. For audiologists and speech-language pathologists craving a lower-tech holiday season professionally and personally, share these 10 tips to make this goal a reality and help families instead embrace conversation, communication and bonding this holiday season. As always, children who use low- and high-tech augmentative and alternative communication devices (AAC) should continue to use them at all times—and in an interactive way. Editor's note: Also enjoy this non-tech holiday gift guide to help kids reduce screen time.  Here are some screen-reduction tips,...

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Mutational and Phenotypic Spectra of KCNE1 deficiency in Jervell and Lange ‐Nielsen Syndrome and Romano‐Ward Syndrome

This article is protected by copyright. All rights reserved (Source: Human Mutation)

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Mutational and Phenotypic Spectra of KCNE1 deficiency in Jervell and Lange ‐Nielsen Syndrome and Romano‐Ward Syndrome

This article is protected by copyright. All rights reserved (Source: Human Mutation)

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Horizontal alveolar transport distraction osteogenesis followed by implant placement

Alveolar transport distraction osteogenesis (ATDO) is an alternative treatment method to vertical alveolar distraction osteogenesis in cases of large bony defects, especially when the bone is limited in size. ATDO was performed in 10 patients with 12 defects. The mean age of the patients was 39.1years. The average bone length gain was 18.2mm. Implants were inserted following a 3-month consolidation period. Three patients needed additional bone grafting for horizontal widening. Final prosthetic rehabilitation was performed at least 3 months following implant insertion. (Source: International Journal of Oral and Maxillofacial Surgery)

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Influence of the anatomical form of the posterior maxilla on the reliability of superior maxillary repositioning by Le Fort I osteotomy

In this study, the correlation between the accuracy of superior repositioning of the maxilla and the anatomical form of the maxillary posterior region was examined. Seventy-five patients who underwent Le Fort I osteotomy without forward movement of the maxilla but with superior repositioning of the maxilla were included in this study. (Source: International Journal of Oral and Maxillofacial Surgery)

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Horizontal alveolar transport distraction osteogenesis followed by implant placement

Alveolar transport distraction osteogenesis (ATDO) is an alternative treatment method to vertical alveolar distraction osteogenesis in cases of large bony defects, especially when the bone is limited in size. ATDO was performed in 10 patients with 12 defects. The mean age of the patients was 39.1years. The average bone length gain was 18.2mm. Implants were inserted following a 3-month consolidation period. Three patients needed additional bone grafting for horizontal widening. Final prosthetic rehabilitation was performed at least 3 months following implant insertion. (Source: International Journal of Oral and Maxillofacial Surgery)

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Influence of the anatomical form of the posterior maxilla on the reliability of superior maxillary repositioning by Le Fort I osteotomy

In this study, the correlation between the accuracy of superior repositioning of the maxilla and the anatomical form of the maxillary posterior region was examined. Seventy-five patients who underwent Le Fort I osteotomy without forward movement of the maxilla but with superior repositioning of the maxilla were included in this study. (Source: International Journal of Oral and Maxillofacial Surgery)

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Pathogenesis investigation of miR ‐199‐5p in oral submucous fibrosis based on bioinformatics analysis

ConclusionThese results indicate that fibrosis ‐related genes are related to a series of complex mechanisms. The characteristics of miR‐199‐5p may supply important clues for developing therapeutic strategy for OSF.This article is protected by copyright. All rights reserved. (Source: Oral Diseases)

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Pathogenesis investigation of miR ‐199‐5p in oral submucous fibrosis based on bioinformatics analysis

ConclusionThese results indicate that fibrosis ‐related genes are related to a series of complex mechanisms. The characteristics of miR‐199‐5p may supply important clues for developing therapeutic strategy for OSF.This article is protected by copyright. All rights reserved. (Source: Oral Diseases)

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Identification of Affective State Change in Adults With Aphasia Using Speech Acoustics.

Conclusions: The results suggest the existence of objectively measurable aspects of speech that may be used to identify changes in acute affect from adults with aphasia. This work is exploratory and hypothesis-generating; more work will be needed to make conclusive claims. Further work in this area could lead to automated tools to assist clinicians with their diagnoses of stress, depression, and other forms of affect in adults with aphasia. PMID: 30481797 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Pointing and placing: Nominal grounding in Argentine Sign Language

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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Laryngeal Vibration Increases Spontaneous Swallowing Rates in Chronic Oropharyngeal Dysphagia: A Proof-of-Principle Pilot Study

In conclusion, as non-invasive neck vibration overlying the larynx increased swallowing rates and the urge to swallow without discomfort in patients with chronic dysphagia, the potential for vibratory stimulation facilitating swallowing during dysphagia reha bilitation should be investigated. (Source: Dysphagia)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qm1K96

Introducing the Beatalk technique: using beatbox sounds and rhythms to improve speech characteristics of adults with intellectual disability.

CONCLUSIONS & IMPLICATIONS: The results present initial evidence for the beneficial effect of the Beatalk technique as an intervention tool for adults with ID. It is an easy-to-use technique in the context of speech therapy, and may enhance verbal communication skills in this population. PMID: 30478972 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BFHh6X

Towards the Quantification of Peggy Babcock: Speech Errors and Their Position within the Word.

This study investigates the role of the location of this partial identity and the accompanying differences, i.e. whether errors are more frequent with mismatches in word onsets (top cop), codas (top tock) or both (pop tot). Number of syllables (tippy ticky) and empty positions (top ta) were also varied. Since the gradient nature of errors can be difficult to determine acoustically, articulatory data were investigated. Articulator movements were recorded using electromagnetic articulography, for up to 9 speakers of American English repeatedly producing 2-word sequences to an accelerating metronome. Most word pairs showed more intrusions and greater variability in coda than in onset position, in contrast to the predominance of onset position errors in corpora from perceptual observation. ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KJLeKY

School-Aged Children's Phonological Accuracy in Multisyllabic Words on a Whole-Word Metric.

Conclusion: Phonological accuracy in MSW production was differentiated for elementary school-aged children with TD and PPD, using a whole-word metric. To assist with the identification of children with ongoing PPD, the metric has the ability to detect weaknesses and track progress in global MSW phonological production. PMID: 30481796 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Hypericin photodynamic activity in DPPC liposome. PART I: biomimetism of loading, location, interactions and thermodynamic properties

Publication date: Available online 28 November 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Flávia A.P. de Morais, Renato S. Gonçalves, Bruno H. Vilsinski, Évelin Lemos de Oliveira, Nicola L. Rocha, Noboru Hioka, Wilker CaetanoAbstractHypericin (Hyp) is a potential photosensitizer drug for Photodynamic Therapy (PDT). However, the high lipophilicity of Hyp prevents its preparation in water. To overcome the Hyp solubility problem, this study uses the liposomal vesicle of DPPC. Otherwise liposome is also one of the most employed artificial systems that mimetizes cell membranes. Our present focus is the interaction of Hyp into DPPC liposome as biomimetic system. We studied the loading, interaction, and localization of Hyp (2.8 μmol L−1) in DPPC (5.4 m...

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Data-Driven Classification of Dysarthria Profiles in Children With Cerebral Palsy.

Conclusion: This study provides initial evidence that different speech profiles exist among 5-year-old children with dysarthria secondary to CP, even among children with similar intelligibility levels, suggesting the potential for developing a pediatric dysarthria classification system that could be used to stratify children with dysarthria into meaningful subgroups for studying speech motor development and efficacy of interventions. PMID: 30481827 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PZmyDT

Pointing and placing: Nominal grounding in Argentine Sign Language

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KERmnp

School-Aged Children's Phonological Accuracy in Multisyllabic Words on a Whole-Word Metric.

Conclusion: Phonological accuracy in MSW production was differentiated for elementary school-aged children with TD and PPD, using a whole-word metric. To assist with the identification of children with ongoing PPD, the metric has the ability to detect weaknesses and track progress in global MSW phonological production. PMID: 30481796 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rh1plm

Laryngeal Vibration Increases Spontaneous Swallowing Rates in Chronic Oropharyngeal Dysphagia: A Proof-of-Principle Pilot Study

In conclusion, as non-invasive neck vibration overlying the larynx increased swallowing rates and the urge to swallow without discomfort in patients with chronic dysphagia, the potential for vibratory stimulation facilitating swallowing during dysphagia reha bilitation should be investigated. (Source: Dysphagia)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qm1K96

Sensitivity to Morphosyntactic Information in Preschool Children With and Without Developmental Language Disorder: A Follow-Up Study.

Conclusions: Despite the groups' similar sentence comprehension abilities and ability to accurately respond to the information provided by the subject noun, children with DLD did not show sensitivity to number information on the fronted auxiliary. This insensitivity is considered in light of these children's weaker command of tense/agreement forms in their speech. Specifically, we consider the possibility that failure to grasp the relation between the subject-verb sequence (e.g., dogs running) and preceding information (e.g., are) in questions in the input contributes to the protracted inconsistency in producing auxiliary forms in obligatory contexts by children with DLD. Supplemental Material: https://ift.tt/2FyHX1S. PMID: 30453333 [PubMed - as supplied by publisher...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DNnCV7

Introducing the Beatalk technique: using beatbox sounds and rhythms to improve speech characteristics of adults with intellectual disability.

CONCLUSIONS & IMPLICATIONS: The results present initial evidence for the beneficial effect of the Beatalk technique as an intervention tool for adults with ID. It is an easy-to-use technique in the context of speech therapy, and may enhance verbal communication skills in this population. PMID: 30478972 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BFHh6X

Data-Driven Classification of Dysarthria Profiles in Children With Cerebral Palsy.

Conclusion: This study provides initial evidence that different speech profiles exist among 5-year-old children with dysarthria secondary to CP, even among children with similar intelligibility levels, suggesting the potential for developing a pediatric dysarthria classification system that could be used to stratify children with dysarthria into meaningful subgroups for studying speech motor development and efficacy of interventions. PMID: 30481827 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PZmyDT

Towards the Quantification of Peggy Babcock: Speech Errors and Their Position within the Word.

This study investigates the role of the location of this partial identity and the accompanying differences, i.e. whether errors are more frequent with mismatches in word onsets (top cop), codas (top tock) or both (pop tot). Number of syllables (tippy ticky) and empty positions (top ta) were also varied. Since the gradient nature of errors can be difficult to determine acoustically, articulatory data were investigated. Articulator movements were recorded using electromagnetic articulography, for up to 9 speakers of American English repeatedly producing 2-word sequences to an accelerating metronome. Most word pairs showed more intrusions and greater variability in coda than in onset position, in contrast to the predominance of onset position errors in corpora from perceptual observation. ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KJLeKY

Identification of Affective State Change in Adults With Aphasia Using Speech Acoustics.

Conclusions: The results suggest the existence of objectively measurable aspects of speech that may be used to identify changes in acute affect from adults with aphasia. This work is exploratory and hypothesis-generating; more work will be needed to make conclusive claims. Further work in this area could lead to automated tools to assist clinicians with their diagnoses of stress, depression, and other forms of affect in adults with aphasia. PMID: 30481797 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PYPGLA

Data-Driven Classification of Dysarthria Profiles in Children With Cerebral Palsy.

Conclusion: This study provides initial evidence that different speech profiles exist among 5-year-old children with dysarthria secondary to CP, even among children with similar intelligibility levels, suggesting the potential for developing a pediatric dysarthria classification system that could be used to stratify children with dysarthria into meaningful subgroups for studying speech motor development and efficacy of interventions. PMID: 30481827 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PZmyDT

School-Aged Children's Phonological Accuracy in Multisyllabic Words on a Whole-Word Metric.

Conclusion: Phonological accuracy in MSW production was differentiated for elementary school-aged children with TD and PPD, using a whole-word metric. To assist with the identification of children with ongoing PPD, the metric has the ability to detect weaknesses and track progress in global MSW phonological production. PMID: 30481796 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rh1plm

Identification of Affective State Change in Adults With Aphasia Using Speech Acoustics.

Conclusions: The results suggest the existence of objectively measurable aspects of speech that may be used to identify changes in acute affect from adults with aphasia. This work is exploratory and hypothesis-generating; more work will be needed to make conclusive claims. Further work in this area could lead to automated tools to assist clinicians with their diagnoses of stress, depression, and other forms of affect in adults with aphasia. PMID: 30481797 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PYPGLA

Sensitivity to Morphosyntactic Information in Preschool Children With and Without Developmental Language Disorder: A Follow-Up Study.

Conclusions: Despite the groups' similar sentence comprehension abilities and ability to accurately respond to the information provided by the subject noun, children with DLD did not show sensitivity to number information on the fronted auxiliary. This insensitivity is considered in light of these children's weaker command of tense/agreement forms in their speech. Specifically, we consider the possibility that failure to grasp the relation between the subject-verb sequence (e.g., dogs running) and preceding information (e.g., are) in questions in the input contributes to the protracted inconsistency in producing auxiliary forms in obligatory contexts by children with DLD. Supplemental Material: https://ift.tt/2FyHX1S. PMID: 30453333 [PubMed - as supplied by publisher...

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CHILDRENS ALLERGY RELIEF (Diphenhydramine Hcl) Liquid [AptaPharma Inc.]

Updated Date: Nov 23, 2018 EST (Source: DailyMed Drug Label Updates)

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ALL DAY ALLERGY RELIEF (Loratadine) Tablet [P L Development, LLC]

Updated Date: Nov 28, 2018 EST (Source: DailyMed Drug Label Updates)

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CHILDRENS ALLERGY RELIEF (Diphenhydramine Hcl) Liquid [AptaPharma Inc.]

Updated Date: Nov 23, 2018 EST (Source: DailyMed Drug Label Updates)

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Indigenous knowledge of dye-yielding plants among Bai communities in Dali, Northwest Yunnan, China

Bai people in the Dali Prefecture of Northwest Yunnan, China, have a long history of using plant extracts to dye their traditional costumes and maintain this culture for posterity. However, the development of ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E38WkE

Traditionally used wild edible plants of district Udhampur, J&K, India

Wild edible plants (WEPs) refer to edible species that are not cultivated or domesticated. WEPs have an important role to play in poverty eradication, security of food availability, diversification of agricult...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ShIk2e

Vocal motor control and central auditory impairments in unilateral vocal fold paralysis

ConclusionCombined central vocal motor control and auditory processing impairments in treated UVFP highlight reciprocal interdependency of sensory and motor systems. This pilot study suggests that peripheral motor impairment of the larynx can degrade central auditory processing, which in turn may contribute to vocal motor control impairment. A more complete restoration communicative function in UVFP will require deeper understanding of sensory, motor, and sensorimotor aspects of the human communication loop.Level of Evidence3bLaryngoscope, 2018 (Source: The Laryngoscope)

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Correlating laryngoscopic appearance of laryngeal lesions with histopathology

ConclusionsLaryngoscopic and microscopic appearance of vascular stippling could inform clinicians on diagnostic sampling of suspicious laryngeal lesions that reduces delay in diagnosis. The low sensitivity of vascular stippling underlies the importance of maintaining high clinical suspicion and proceeding to the operating theater for adequate tissue sampling.Level of Evidence3Laryngoscope, 2018 (Source: The Laryngoscope)

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When to replace legacy cochlear implants for technological upgrades: Indications and outcomes

ConclusionPost ‐CIR audiological benefit was stable or improved compared to pre‐CIR results in all categories by 3 months after reactivation. Given these results, patients who are unable to use the most current external processors due to incompatibility with a legacy internal device could consider reimplanatio n to optimize their overall performance with a cochlear implant.Level of Evidence4.Laryngoscope, 2018 (Source: The Laryngoscope)

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SDHx gene detection and clinical Phenotypic analysis of multiple paraganglioma in the head and neck

ConclusionIn patients with multiple PGL in the head and neck, these are accompanied by a genetic mutation of the germ cell. In this case study, this mutation was most commonly a mutation of the SDHD gene.Level of Evidence4.Laryngoscope, 2018 (Source: The Laryngoscope)

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Infections of the Ears, Nose, Throat, and Sinuses. Edited by Marlene L. Durand and Daniel G. Deschler . Heidelberg, Germany: Springer; 2018; 404 pp. $199.00

The Laryngoscope, EarlyView. (Source: The Laryngoscope)

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Indigenous knowledge of dye-yielding plants among Bai communities in Dali, Northwest Yunnan, China

Bai people in the Dali Prefecture of Northwest Yunnan, China, have a long history of using plant extracts to dye their traditional costumes and maintain this culture for posterity. However, the development of ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E38WkE

Traditionally used wild edible plants of district Udhampur, J&K, India

Wild edible plants (WEPs) refer to edible species that are not cultivated or domesticated. WEPs have an important role to play in poverty eradication, security of food availability, diversification of agricult...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ShIk2e

Vocal motor control and central auditory impairments in unilateral vocal fold paralysis

ConclusionCombined central vocal motor control and auditory processing impairments in treated UVFP highlight reciprocal interdependency of sensory and motor systems. This pilot study suggests that peripheral motor impairment of the larynx can degrade central auditory processing, which in turn may contribute to vocal motor control impairment. A more complete restoration communicative function in UVFP will require deeper understanding of sensory, motor, and sensorimotor aspects of the human communication loop.Level of Evidence3bLaryngoscope, 2018 (Source: The Laryngoscope)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SiTNP7

Correlating laryngoscopic appearance of laryngeal lesions with histopathology

ConclusionsLaryngoscopic and microscopic appearance of vascular stippling could inform clinicians on diagnostic sampling of suspicious laryngeal lesions that reduces delay in diagnosis. The low sensitivity of vascular stippling underlies the importance of maintaining high clinical suspicion and proceeding to the operating theater for adequate tissue sampling.Level of Evidence3Laryngoscope, 2018 (Source: The Laryngoscope)

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When to replace legacy cochlear implants for technological upgrades: Indications and outcomes

ConclusionPost ‐CIR audiological benefit was stable or improved compared to pre‐CIR results in all categories by 3 months after reactivation. Given these results, patients who are unable to use the most current external processors due to incompatibility with a legacy internal device could consider reimplanatio n to optimize their overall performance with a cochlear implant.Level of Evidence4.Laryngoscope, 2018 (Source: The Laryngoscope)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rcU36W

SDHx gene detection and clinical Phenotypic analysis of multiple paraganglioma in the head and neck

ConclusionIn patients with multiple PGL in the head and neck, these are accompanied by a genetic mutation of the germ cell. In this case study, this mutation was most commonly a mutation of the SDHD gene.Level of Evidence4.Laryngoscope, 2018 (Source: The Laryngoscope)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SiTK5T

Infections of the Ears, Nose, Throat, and Sinuses. Edited by Marlene L. Durand and Daniel G. Deschler . Heidelberg, Germany: Springer; 2018; 404 pp. $199.00

The Laryngoscope, EarlyView. (Source: The Laryngoscope)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E1Akj9

When to replace legacy cochlear implants for technological upgrades: Indications and outcomes

ConclusionPost ‐CIR audiological benefit was stable or improved compared to pre‐CIR results in all categories by 3 months after reactivation. Given these results, patients who are unable to use the most current external processors due to incompatibility with a legacy internal device could consider reimplanatio n to optimize their overall performance with a cochlear implant.Level of Evidence4.Laryngoscope, 2018 (Source: The Laryngoscope)

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Arabic version of situational characteristic questionnaire for diagnosis of visual vertigo syndrome

. (Source: Hearing, Balance and Communication)

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Cochlear implantation in a 10-year old boy with Pendred syndrome and extremely enlarged endolymphatic sacs

. (Source: Cochlear Implants International)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rbUbU5

When to replace legacy cochlear implants for technological upgrades: Indications and outcomes

ConclusionPost ‐CIR audiological benefit was stable or improved compared to pre‐CIR results in all categories by 3 months after reactivation. Given these results, patients who are unable to use the most current external processors due to incompatibility with a legacy internal device could consider reimplanatio n to optimize their overall performance with a cochlear implant.Level of Evidence4.Laryngoscope, 2018 (Source: The Laryngoscope)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rcU36W

Arabic version of situational characteristic questionnaire for diagnosis of visual vertigo syndrome

. (Source: Hearing, Balance and Communication)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FMP1Iu

Cochlear implantation in a 10-year old boy with Pendred syndrome and extremely enlarged endolymphatic sacs

. (Source: Cochlear Implants International)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rbUbU5

Elevated expression of IL-17RB and ST2 on myeloid dendritic cells is associated with a Th2-skewed eosinophilic inflammation in nasal polyps

Abstract

Background

Interleukin(IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) underlie the crosstalk between epithelial cells and dendritic cells (DCs) during the development of Th2 responses. This study aimed to measure the expressions of IL-17RB, ST2 and TSLPR, receptor of IL-25, IL-33, and TSLP respectively, on myeloid DCs in nasal polyps (NP) and evaluate their association with local Th2 inflammation and disease severity in patients with NP.

Methods

Samples were collected from 30 NP patients and 16 control subjects recruited prospectively. The mRNA expression of cytokines, including TSLP, IL-25 and IL-33, as well as interferon (IFN)-γ, IL-4, IL-5, IL-13 and IL-17A in NP and control tissues was examined by qualitative polymerase chain reaction (qPCR). The expression of IL-17RB, ST2 and TSLPR as well as other surface markers on myeloid DCs (mDCs) was examined by flow cytometry.

Results

Increased numbers of total and activated mDCs were found in NP patients. mDCs demonstrated significantly higher expression of IL-17RB, ST2 and TSLPR than those in control tissues. The activated mDCs exhibited up-regulations of OX40L and ICOSL, but down-regulation of PDL1 in NP. Moreover, the IL-17RB, ST2 and TSLPR levels on mDCs were positively correlated with IL-25, IL-33 and TSLP mRNA levels, respectively, in NP. Furthermore, IL-17RB and ST2 expressions on mDCs were correlated with the IL-5 mRNA level as well as eosinophil number in NP. Importantly, the IL-17RB expression on mDCs and the OX40L expression on activated mDCs in NP were positively correlated with CT score and total nasal symptom score.

Conclusions

Increased expressions of IL-17RB and ST2 on mDCs are associated with enhanced local Th2 inflammation in NP, suggesting that mDCs might play a role in IL-25- and IL-33-induced type 2 responses and eosinophilic inflammation in NP.

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Elevated expression of IL-17RB and ST2 on myeloid dendritic cells is associated with a Th2-skewed eosinophilic inflammation in nasal polyps

Abstract

Background

Interleukin(IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) underlie the crosstalk between epithelial cells and dendritic cells (DCs) during the development of Th2 responses. This study aimed to measure the expressions of IL-17RB, ST2 and TSLPR, receptor of IL-25, IL-33, and TSLP respectively, on myeloid DCs in nasal polyps (NP) and evaluate their association with local Th2 inflammation and disease severity in patients with NP.

Methods

Samples were collected from 30 NP patients and 16 control subjects recruited prospectively. The mRNA expression of cytokines, including TSLP, IL-25 and IL-33, as well as interferon (IFN)-γ, IL-4, IL-5, IL-13 and IL-17A in NP and control tissues was examined by qualitative polymerase chain reaction (qPCR). The expression of IL-17RB, ST2 and TSLPR as well as other surface markers on myeloid DCs (mDCs) was examined by flow cytometry.

Results

Increased numbers of total and activated mDCs were found in NP patients. mDCs demonstrated significantly higher expression of IL-17RB, ST2 and TSLPR than those in control tissues. The activated mDCs exhibited up-regulations of OX40L and ICOSL, but down-regulation of PDL1 in NP. Moreover, the IL-17RB, ST2 and TSLPR levels on mDCs were positively correlated with IL-25, IL-33 and TSLP mRNA levels, respectively, in NP. Furthermore, IL-17RB and ST2 expressions on mDCs were correlated with the IL-5 mRNA level as well as eosinophil number in NP. Importantly, the IL-17RB expression on mDCs and the OX40L expression on activated mDCs in NP were positively correlated with CT score and total nasal symptom score.

Conclusions

Increased expressions of IL-17RB and ST2 on mDCs are associated with enhanced local Th2 inflammation in NP, suggesting that mDCs might play a role in IL-25- and IL-33-induced type 2 responses and eosinophilic inflammation in NP.

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Type 1 Diabetes Incidence Set to Double in 20 Years in Europe Type 1 Diabetes Incidence Set to Double in 20 Years in Europe

Incidence of type 1 diabetes in children is continuing to rise, by around 3% per year, across Europe according to large 25-year study covering 22 countries.Medscape Medical News (Source: Medscape Allergy Headlines)

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Type 1 Diabetes Incidence Set to Double in 20 Years in Europe Type 1 Diabetes Incidence Set to Double in 20 Years in Europe

Incidence of type 1 diabetes in children is continuing to rise, by around 3% per year, across Europe according to large 25-year study covering 22 countries.Medscape Medical News (Source: Medscape Allergy Headlines)

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Type 1 Diabetes Incidence Set to Double in 20 Years in Europe Type 1 Diabetes Incidence Set to Double in 20 Years in Europe

Incidence of type 1 diabetes in children is continuing to rise, by around 3% per year, across Europe according to large 25-year study covering 22 countries.Medscape Medical News (Source: Medscape Allergy Headlines)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KEK7vZ

Type 1 Diabetes Incidence Set to Double in 20 Years in Europe Type 1 Diabetes Incidence Set to Double in 20 Years in Europe

Incidence of type 1 diabetes in children is continuing to rise, by around 3% per year, across Europe according to large 25-year study covering 22 countries.Medscape Medical News (Source: Medscape Allergy Headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Der p 1‐specific regulatory T cell response during house dust mite allergen immunotherapy

Abstract

Background

Allergen‐specific immunotherapy (AIT) is the only available treatment for allergic diseases that can induce specific immune tolerance to allergens. The key mechanisms involved in this process include changes in allergen‐specific regulatory T (Treg) cells.

Methods

We studied 25 allergic rhinitis patients undergoing subcutaneous house dust mite‐specific immunotherapy. Peripheral blood mononuclear cells were studied before, after 10 weeks, 30 weeks and 3 years of AIT. Der p 1‐specific T regulatory cell responses was investigated by characterization of Der p 1‐MHC‐class II tetramer‐positive cells and correlated with nasal symptom score.

Results

Twelve of 25 AIT patients matched with their MHC‐class II expression to the Der p 1 peptide‐MHC‐class II tetramers. A significant increase in the numbers of Der p 1‐specific FOXP3⁺Helios⁺CD25⁺CD127^‐ Treg cells after 30 weeks was observed, which slightly decreased after 3 years of AIT. In contrast, Der p 1‐specific immunoglobulin‐like transcript 3 (ILT3)⁺CD25⁺ Treg cells decreased substantially from baseline after 3 years of AIT. ILT3⁺ Treg cells displayed compromised suppressive function and low FOXP3 expression. In addition, Der p 1‐specific IL‐10 and IL‐22 responses have increased after 30 weeks, but only IL‐10⁺ Der p 1‐specific Treg cells remained present at high frequency after 3 years of AIT. Increased number of FOXP3⁺Helios⁺, IL‐10⁺ and decreased ILT3⁺ Treg cell responses correlated with improved allergic symptoms.

Conclusion

The results indicate that AIT involves upregulation of the activated allergen‐specific Treg cells and downregulation of dysfunctional allergen‐specific Treg cells subset. Correction of dysregulated Treg cells responses during AIT is associated with improved clinical response.

This article is protected by copyright. All rights reserved.

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Der p 1‐specific regulatory T cell response during house dust mite allergen immunotherapy

Abstract

Background

Allergen‐specific immunotherapy (AIT) is the only available treatment for allergic diseases that can induce specific immune tolerance to allergens. The key mechanisms involved in this process include changes in allergen‐specific regulatory T (Treg) cells.

Methods

We studied 25 allergic rhinitis patients undergoing subcutaneous house dust mite‐specific immunotherapy. Peripheral blood mononuclear cells were studied before, after 10 weeks, 30 weeks and 3 years of AIT. Der p 1‐specific T regulatory cell responses was investigated by characterization of Der p 1‐MHC‐class II tetramer‐positive cells and correlated with nasal symptom score.

Results

Twelve of 25 AIT patients matched with their MHC‐class II expression to the Der p 1 peptide‐MHC‐class II tetramers. A significant increase in the numbers of Der p 1‐specific FOXP3⁺Helios⁺CD25⁺CD127^‐ Treg cells after 30 weeks was observed, which slightly decreased after 3 years of AIT. In contrast, Der p 1‐specific immunoglobulin‐like transcript 3 (ILT3)⁺CD25⁺ Treg cells decreased substantially from baseline after 3 years of AIT. ILT3⁺ Treg cells displayed compromised suppressive function and low FOXP3 expression. In addition, Der p 1‐specific IL‐10 and IL‐22 responses have increased after 30 weeks, but only IL‐10⁺ Der p 1‐specific Treg cells remained present at high frequency after 3 years of AIT. Increased number of FOXP3⁺Helios⁺, IL‐10⁺ and decreased ILT3⁺ Treg cell responses correlated with improved allergic symptoms.

Conclusion

The results indicate that AIT involves upregulation of the activated allergen‐specific Treg cells and downregulation of dysfunctional allergen‐specific Treg cells subset. Correction of dysregulated Treg cells responses during AIT is associated with improved clinical response.

This article is protected by copyright. All rights reserved.

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Eine seltene Ursache der asymptomatischen Arteria carotis interna Dissektion

Laryngo-Rhino-Otol
DOI: 10.1055/a-0798-3615

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

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Eine seltene Ursache der asymptomatischen Arteria carotis interna Dissektion

Laryngo-Rhino-Otol
DOI: 10.1055/a-0798-3615

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

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Type 1 Diabetes Incidence Set to Double in 20 Years in Europe Type 1 Diabetes Incidence Set to Double in 20 Years in Europe

Incidence of type 1 diabetes in children is continuing to rise, by around 3% per year, across Europe according to large 25-year study covering 22 countries.Medscape Medical News (Source: Medscape Allergy Headlines)

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Type 1 Diabetes Incidence Set to Double in 20 Years in Europe Type 1 Diabetes Incidence Set to Double in 20 Years in Europe

Incidence of type 1 diabetes in children is continuing to rise, by around 3% per year, across Europe according to large 25-year study covering 22 countries.Medscape Medical News (Source: Medscape Allergy Headlines)

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Allergic contact dermatitis caused by timolol eyedrops application for infantile hemangioma

Allergic contact dermatitis (ACD) caused by timolol eyedrops is well‐known (1, 2) while ACD following its use for infantile hemangiomas has hitherto not been reported.

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Allergic contact dermatitis caused by timolol eyedrops application for infantile hemangioma

Allergic contact dermatitis (ACD) caused by timolol eyedrops is well‐known (1, 2) while ACD following its use for infantile hemangiomas has hitherto not been reported.

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Chromium(III), chromium(VI) and cobalt release from leathers produced in Nicaragua

Background

Leather exposure has been associated with chromium (Cr) and cobalt (Co) contact dermatitis. Cr(VI) in leather is now restricted to <3 mg/kg in the EU. Cr(III) is not restricted.

Objectives

To analyse 29 differently coloured Cr‐tanned leather samples from two Nicaraguan tanneries, and to compare their release of Cr, Cr(VI) and Co with that of leathers produced in Europe.

Methods

Cr, Cr(VI) and Co were extracted in phosphate buffer for 3 hours at 25°C according to EN ISO 17075. Atomic absorption spectroscopy and spectrophotometry were used for detection of the metals in phosphate buffer.

Results

There was no difference in total Cr or Cr(VI) release between European and Nicaraguan leathers. There was no association between Cr(VI) and total Cr release. Co was released primarily from leathers of one tannery. Cr(III) was released in significantly higher amounts than Cr(VI).

Conclusions

Future investigations and regulations should focus on Cr(III) and Co as well as on Cr(VI).

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Chromium(III), chromium(VI) and cobalt release from leathers produced in Nicaragua

Background

Leather exposure has been associated with chromium (Cr) and cobalt (Co) contact dermatitis. Cr(VI) in leather is now restricted to <3 mg/kg in the EU. Cr(III) is not restricted.

Objectives

To analyse 29 differently coloured Cr‐tanned leather samples from two Nicaraguan tanneries, and to compare their release of Cr, Cr(VI) and Co with that of leathers produced in Europe.

Methods

Cr, Cr(VI) and Co were extracted in phosphate buffer for 3 hours at 25°C according to EN ISO 17075. Atomic absorption spectroscopy and spectrophotometry were used for detection of the metals in phosphate buffer.

Results

There was no difference in total Cr or Cr(VI) release between European and Nicaraguan leathers. There was no association between Cr(VI) and total Cr release. Co was released primarily from leathers of one tannery. Cr(III) was released in significantly higher amounts than Cr(VI).

Conclusions

Future investigations and regulations should focus on Cr(III) and Co as well as on Cr(VI).

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Associated factors of multiple contact allergies in Thai dermatitis patients: A 10‐year retrospective study

Background

Multiple contact allergies (MCA) are evidenced by 3 or more positive patch test reactions to unrelated antigens. Factors associated with MCA include female gender, older age, and certain eczema sites.

Objectives

To investigate the prevalence of MCA, risk factors for their development, and patterns of allergen combinations.

Methods

This retrospective, case‐control study was conducted on patients suspected of having allergic contact dermatitis who had been patch tested with a baseline series during January 2007 through December 2016.

Results

Of the 2 178 included patients, 531 (24.4%) had MCA. A multivariate analysis found that a generalized distribution of dermatitis represented the highest risk factor (OR 3.97), followed by a history of metal allergy (OR 3.18). The other significantly associated factors were, in order of decreasing frequency, the dermatitis sites (hands/feet, extremities, and face); age ≥ 25 years; and occupationally related dermatitis; their ORs were < 3.

Conclusions

The significantly associated factors of MCA were identified. The ranking of the common contact allergens among the MCA patients was comparable with that of the non‐MCA patients. Metal and fragrance allergens were frequently found to cause concurrent positive reactions in the MCA patients.

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Associated factors of multiple contact allergies in Thai dermatitis patients: A 10‐year retrospective study

Background

Multiple contact allergies (MCA) are evidenced by 3 or more positive patch test reactions to unrelated antigens. Factors associated with MCA include female gender, older age, and certain eczema sites.

Objectives

To investigate the prevalence of MCA, risk factors for their development, and patterns of allergen combinations.

Methods

This retrospective, case‐control study was conducted on patients suspected of having allergic contact dermatitis who had been patch tested with a baseline series during January 2007 through December 2016.

Results

Of the 2 178 included patients, 531 (24.4%) had MCA. A multivariate analysis found that a generalized distribution of dermatitis represented the highest risk factor (OR 3.97), followed by a history of metal allergy (OR 3.18). The other significantly associated factors were, in order of decreasing frequency, the dermatitis sites (hands/feet, extremities, and face); age ≥ 25 years; and occupationally related dermatitis; their ORs were < 3.

Conclusions

The significantly associated factors of MCA were identified. The ranking of the common contact allergens among the MCA patients was comparable with that of the non‐MCA patients. Metal and fragrance allergens were frequently found to cause concurrent positive reactions in the MCA patients.

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Allergic contact dermatitis due to chloramphenicol with prurigo nodularis‐like spreading

Topical drugs containing chloramphenicol and clostridiopeptidase A are frequently used for the treatment of cutaneous ulcers and other necrotic lesions. Chloramphenicol is a bacteriostatic broad‐spectrum antibiotic widely used in eye and skin ointments to treat bacterial infections and a well‐known cause of allergic contact dermatitis (ACD) (1). Clostridiopeptidase A, also called collagenase 1, is a proteolytic enzyme facilitating the tissue granulation with consequent re‐epithelization; it has rarely been reported as cause of ACD (2).

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Allergic contact dermatitis due to chloramphenicol with prurigo nodularis‐like spreading

Topical drugs containing chloramphenicol and clostridiopeptidase A are frequently used for the treatment of cutaneous ulcers and other necrotic lesions. Chloramphenicol is a bacteriostatic broad‐spectrum antibiotic widely used in eye and skin ointments to treat bacterial infections and a well‐known cause of allergic contact dermatitis (ACD) (1). Clostridiopeptidase A, also called collagenase 1, is a proteolytic enzyme facilitating the tissue granulation with consequent re‐epithelization; it has rarely been reported as cause of ACD (2).

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LATISSIMUS DORSI BREAST RECONSTRUCTION WITH OR WITHOUT IMPLANTS: A COMPARISON BETWEEN OUTCOME AND PATIENT SATISFACTION

The Latissimus Dorsi (LD) flap is largely used in breast reconstruction. The aim of this study is to evaluate the advantage of the LD flap in association with implant compared to LD breast reconstruction in association with lipofilling to add additional volume, by assessing the number of revision procedures, the length of hospitalization, the complication rate and patient satisfaction.

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Letter To The Editor- Sentinel lymph node biopsy in melanoma: Which hot nodes should be harvested and is blue dye really necessary?

We read with great interest the review by dr. Ranson and collegues about sentinel lymph node biopsy in melanoma, which hot nodes should be harvested and whether blue dye is really necessary. First of all, we congratulate the author on an excellent paper, but we also feel that there are some issues that need to be addressed.

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Letter To The Editor- Sentinel lymph node biopsy in melanoma: Which hot nodes should be harvested and is blue dye really necessary?

We read with great interest the review by dr. Ranson and collegues about sentinel lymph node biopsy in melanoma, which hot nodes should be harvested and whether blue dye is really necessary. First of all, we congratulate the author on an excellent paper, but we also feel that there are some issues that need to be addressed.

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LATISSIMUS DORSI BREAST RECONSTRUCTION WITH OR WITHOUT IMPLANTS: A COMPARISON BETWEEN OUTCOME AND PATIENT SATISFACTION

The Latissimus Dorsi (LD) flap is largely used in breast reconstruction. The aim of this study is to evaluate the advantage of the LD flap in association with implant compared to LD breast reconstruction in association with lipofilling to add additional volume, by assessing the number of revision procedures, the length of hospitalization, the complication rate and patient satisfaction.

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Cartilage exposure following autologous microtia reconstruction: an algorithmic treatment approach

Successful reconstruction of microtia involves fabrication of a cartilaginous framework and provision of thin, durable, soft tissue cover. Vascular compromise of this skin envelope can lead to exposure of the underlying cartilage, resulting in cartilage resorption and distortion of the final form of the ear construct. We describe our algorithm for management of this complication.

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Cartilage exposure following autologous microtia reconstruction: an algorithmic treatment approach

Successful reconstruction of microtia involves fabrication of a cartilaginous framework and provision of thin, durable, soft tissue cover. Vascular compromise of this skin envelope can lead to exposure of the underlying cartilage, resulting in cartilage resorption and distortion of the final form of the ear construct. We describe our algorithm for management of this complication.

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Medial iliac stress fractures in athletes: report of two rare cases: review of literature and clinical recommendations

Abstract

Stress fractures are a common diagnosis in sports medicine and can result in significant loss of function, athlete playing time, and potentially lead to chronic symptoms. However, unusual locations of stress fractures may present with vague symptoms and a relatively benign physical exam, leading to difficulty in arriving at the correct diagnosis. Pelvic stress fractures are less common than lower-extremity stress fractures in athletes, occurring in only 1–5% of all stress fractures and typically occur in pubic rami. Furthermore, iliac bone stress fractures are even rarer, with only a few case reports in the literature. Their presentation can easily be missed on routine workup and imaging. We present two cases of the very rare superomedial iliac bone stress fracture in athletes, an unusual location for this uncommon stress fracture. We review the available literature on this condition and provide clinical commentary on workup and treatment recommendations.

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Medial iliac stress fractures in athletes: report of two rare cases: review of literature and clinical recommendations

Abstract

Stress fractures are a common diagnosis in sports medicine and can result in significant loss of function, athlete playing time, and potentially lead to chronic symptoms. However, unusual locations of stress fractures may present with vague symptoms and a relatively benign physical exam, leading to difficulty in arriving at the correct diagnosis. Pelvic stress fractures are less common than lower-extremity stress fractures in athletes, occurring in only 1–5% of all stress fractures and typically occur in pubic rami. Furthermore, iliac bone stress fractures are even rarer, with only a few case reports in the literature. Their presentation can easily be missed on routine workup and imaging. We present two cases of the very rare superomedial iliac bone stress fracture in athletes, an unusual location for this uncommon stress fracture. We review the available literature on this condition and provide clinical commentary on workup and treatment recommendations.

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Influence of the anatomical form of the posterior maxilla on the reliability of superior maxillary repositioning by Le Fort I osteotomy

Certain patients with facial deformities require superior repositioning of the maxilla via Le Fort I osteotomy; however, the magnitude of superior repositioning of the maxilla is often less than expected. In this study, the correlation between the accuracy of superior repositioning of the maxilla and the anatomical form of the maxillary posterior region was examined. Seventy-five patients who underwent Le Fort I osteotomy without forward movement of the maxilla but with superior repositioning of the maxilla were included in this study.

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Horizontal alveolar transport distraction osteogenesis followed by implant placement

Alveolar transport distraction osteogenesis (ATDO) is an alternative treatment method to vertical alveolar distraction osteogenesis in cases of large bony defects, especially when the bone is limited in size. ATDO was performed in 10 patients with 12 defects. The mean age of the patients was 39.1years. The average bone length gain was 18.2mm. Implants were inserted following a 3-month consolidation period. Three patients needed additional bone grafting for horizontal widening. Final prosthetic rehabilitation was performed at least 3 months following implant insertion.

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Influence of the anatomical form of the posterior maxilla on the reliability of superior maxillary repositioning by Le Fort I osteotomy

Certain patients with facial deformities require superior repositioning of the maxilla via Le Fort I osteotomy; however, the magnitude of superior repositioning of the maxilla is often less than expected. In this study, the correlation between the accuracy of superior repositioning of the maxilla and the anatomical form of the maxillary posterior region was examined. Seventy-five patients who underwent Le Fort I osteotomy without forward movement of the maxilla but with superior repositioning of the maxilla were included in this study.

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Horizontal alveolar transport distraction osteogenesis followed by implant placement

Alveolar transport distraction osteogenesis (ATDO) is an alternative treatment method to vertical alveolar distraction osteogenesis in cases of large bony defects, especially when the bone is limited in size. ATDO was performed in 10 patients with 12 defects. The mean age of the patients was 39.1years. The average bone length gain was 18.2mm. Implants were inserted following a 3-month consolidation period. Three patients needed additional bone grafting for horizontal widening. Final prosthetic rehabilitation was performed at least 3 months following implant insertion.

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Assessing Improvement of Patient Satisfaction Following Facelift Surgery Using the FACE-Q Scales: A Prospective and Multicenter Study

Abstract

Introduction

Assessment of patient satisfaction following an aesthetic surgery has shown an increasing trend over the past years. To date, there is no prospective and comprehensive study evaluating this aspect after surgical facial and neck rejuvenation. The aim of the current work was to address patient satisfaction after face and neck lift surgery using a validated questionnaire.

Patients and Methods

We present a prospective and multicenter study (five regional centers) involving all patients undergoing face and neck lift surgery between April 2015 and April 2017 in several French centers for aesthetic surgery. All subjects assessed the FACE-Q scales before the procedure, and furtherly at 3-month, 6-month and 12-month follow-ups.

Results

Thirty-six patients were included with a median age of 58.5 years old [IQR 54.0–66.0]. The FACE-Q outcomes were significantly higher at 3-month follow-up (p < 0.001). Seventy-five percent of the patients underwent an additional surgical procedure associated with face and neck lift. Particularly, a combined blepharoplasty led to a significant increase in the score of global facial appearance. The patients considered themselves a mean of 6 years younger in the third month after surgery. These results remained constant at six and twelve postoperative months.

Conclusion

A statistically significant improvement of the FACE-Q scores could be highlighted on every scale, with permanent results at 6 and 12 months postsurgery. We hereby present the first study with evidence that appearance and quality of life outcomes can be reliably assessed after rhytidectomy.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Lab-grown placentas 'will transform pregnancy research'

Cambridge team develops organoids or mini placentas to advance knowledge of stillbirth and pre-eclampsiaScientists have grown "mini placentas" in a breakthrough that could transform research into the underlying causes of miscarriage, stillbirth and other pregnancy disorders.The tiny organoids mimic the placenta in the early stages of the first trimester and will be used to understand how the tissue develops in healthy pregnancies, and what goes wrong when it fails.Continue reading... (Source: Guardian Unlimited Science)

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Assessing Improvement of Patient Satisfaction Following Facelift Surgery Using the FACE-Q Scales: A Prospective and Multicenter Study

Abstract

Introduction

Assessment of patient satisfaction following an aesthetic surgery has shown an increasing trend over the past years. To date, there is no prospective and comprehensive study evaluating this aspect after surgical facial and neck rejuvenation. The aim of the current work was to address patient satisfaction after face and neck lift surgery using a validated questionnaire.

Patients and Methods

We present a prospective and multicenter study (five regional centers) involving all patients undergoing face and neck lift surgery between April 2015 and April 2017 in several French centers for aesthetic surgery. All subjects assessed the FACE-Q scales before the procedure, and furtherly at 3-month, 6-month and 12-month follow-ups.

Results

Thirty-six patients were included with a median age of 58.5 years old [IQR 54.0–66.0]. The FACE-Q outcomes were significantly higher at 3-month follow-up (p < 0.001). Seventy-five percent of the patients underwent an additional surgical procedure associated with face and neck lift. Particularly, a combined blepharoplasty led to a significant increase in the score of global facial appearance. The patients considered themselves a mean of 6 years younger in the third month after surgery. These results remained constant at six and twelve postoperative months.

Conclusion

A statistically significant improvement of the FACE-Q scores could be highlighted on every scale, with permanent results at 6 and 12 months postsurgery. We hereby present the first study with evidence that appearance and quality of life outcomes can be reliably assessed after rhytidectomy.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Lab-grown placentas 'will transform pregnancy research'

Cambridge team develops organoids or mini placentas to advance knowledge of stillbirth and pre-eclampsiaScientists have grown "mini placentas" in a breakthrough that could transform research into the underlying causes of miscarriage, stillbirth and other pregnancy disorders.The tiny organoids mimic the placenta in the early stages of the first trimester and will be used to understand how the tissue develops in healthy pregnancies, and what goes wrong when it fails.Continue reading... (Source: Guardian Unlimited Science)

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Lab-grown placentas 'will transform pregnancy research'

Cambridge team develops organoids or mini placentas to advance knowledge of stillbirth and pre-eclampsiaScientists have grown "mini placentas" in a breakthrough that could transform research into the underlying causes of miscarriage, stillbirth and other pregnancy disorders.The tiny organoids mimic the placenta in the early stages of the first trimester and will be used to understand how the tissue develops in healthy pregnancies, and what goes wrong when it fails.Continue reading... (Source: Guardian Unlimited Science)

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Lab-grown placentas 'will transform pregnancy research'

Cambridge team develops organoids or mini placentas to advance knowledge of stillbirth and pre-eclampsiaScientists have grown "mini placentas" in a breakthrough that could transform research into the underlying causes of miscarriage, stillbirth and other pregnancy disorders.The tiny organoids mimic the placenta in the early stages of the first trimester and will be used to understand how the tissue develops in healthy pregnancies, and what goes wrong when it fails.Continue reading... (Source: Guardian Unlimited Science)

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Assessing Improvement of Patient Satisfaction Following Facelift Surgery Using the FACE-Q Scales: A Prospective and Multicenter Study

Abstract

Introduction

Assessment of patient satisfaction following an aesthetic surgery has shown an increasing trend over the past years. To date, there is no prospective and comprehensive study evaluating this aspect after surgical facial and neck rejuvenation. The aim of the current work was to address patient satisfaction after face and neck lift surgery using a validated questionnaire.

Patients and Methods

We present a prospective and multicenter study (five regional centers) involving all patients undergoing face and neck lift surgery between April 2015 and April 2017 in several French centers for aesthetic surgery. All subjects assessed the FACE-Q scales before the procedure, and furtherly at 3-month, 6-month and 12-month follow-ups.

Results

Thirty-six patients were included with a median age of 58.5 years old [IQR 54.0–66.0]. The FACE-Q outcomes were significantly higher at 3-month follow-up (p < 0.001). Seventy-five percent of the patients underwent an additional surgical procedure associated with face and neck lift. Particularly, a combined blepharoplasty led to a significant increase in the score of global facial appearance. The patients considered themselves a mean of 6 years younger in the third month after surgery. These results remained constant at six and twelve postoperative months.

Conclusion

A statistically significant improvement of the FACE-Q scores could be highlighted on every scale, with permanent results at 6 and 12 months postsurgery. We hereby present the first study with evidence that appearance and quality of life outcomes can be reliably assessed after rhytidectomy.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q1ZyUW

Assessing Improvement of Patient Satisfaction Following Facelift Surgery Using the FACE-Q Scales: A Prospective and Multicenter Study

Abstract

Introduction

Assessment of patient satisfaction following an aesthetic surgery has shown an increasing trend over the past years. To date, there is no prospective and comprehensive study evaluating this aspect after surgical facial and neck rejuvenation. The aim of the current work was to address patient satisfaction after face and neck lift surgery using a validated questionnaire.

Patients and Methods

We present a prospective and multicenter study (five regional centers) involving all patients undergoing face and neck lift surgery between April 2015 and April 2017 in several French centers for aesthetic surgery. All subjects assessed the FACE-Q scales before the procedure, and furtherly at 3-month, 6-month and 12-month follow-ups.

Results

Thirty-six patients were included with a median age of 58.5 years old [IQR 54.0–66.0]. The FACE-Q outcomes were significantly higher at 3-month follow-up (p < 0.001). Seventy-five percent of the patients underwent an additional surgical procedure associated with face and neck lift. Particularly, a combined blepharoplasty led to a significant increase in the score of global facial appearance. The patients considered themselves a mean of 6 years younger in the third month after surgery. These results remained constant at six and twelve postoperative months.

Conclusion

A statistically significant improvement of the FACE-Q scores could be highlighted on every scale, with permanent results at 6 and 12 months postsurgery. We hereby present the first study with evidence that appearance and quality of life outcomes can be reliably assessed after rhytidectomy.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Laryngeal Vibration Increases Spontaneous Swallowing Rates in Chronic Oropharyngeal Dysphagia: A Proof-of-Principle Pilot Study

In conclusion, as non-invasive neck vibration overlying the larynx increased swallowing rates and the urge to swallow without discomfort in patients with chronic dysphagia, the potential for vibratory stimulation facilitating swallowing during dysphagia reha bilitation should be investigated. (Source: Dysphagia)

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