Publication date: Available online 28 November 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Flávia A.P. de Morais, Renato S. Gonçalves, Bruno H. Vilsinski, Évelin Lemos de Oliveira, Nicola L. Rocha, Noboru Hioka, Wilker CaetanoAbstractHypericin (Hyp) is a potential photosensitizer drug for Photodynamic Therapy (PDT). However, the high lipophilicity of Hyp prevents its preparation in water. To overcome the Hyp solubility problem, this study uses the liposomal vesicle of DPPC. Otherwise liposome is also one of the most employed artificial systems that mimetizes cell membranes. Our present focus is the interaction of Hyp into DPPC liposome as biomimetic system. We studied the loading, interaction, and localization of Hyp (2.8 μmol L−1) in DPPC (5.4 m...
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