Improving image quality with model-based iterative reconstruction algorithm for chest CT in children with reduced contrast concentration

Abstract

Objective

To evaluate model-based iterative reconstruction (MBIR) in improving the image quality of chest CT in children with reduced concentration contrast medium (CM).

Methods

Fifty-six children (median age of 4 years) who received low-dose enhanced chest CT were enrolled as the study group and compared with the control group of 56 children. Both groups used the automatic tube current modulation to achieve age-based noise index values of 11–15 HU. The study group used 100 kVp and reduced CM concentration of 270 mgI/ml, and the images in this group were reconstructed with 50% adaptive statistical iterative reconstruction (ASIR) and MBIR. The control group used 120 kV and standard CM of 320 mgI/ml, and the images in this group were reconstructed with ASIR only. Subjective image quality and objective image quality of the three image sets were evaluated. The subjective quality included overall image noise, enhancement degree, lesion (including mediastinum mass, pulmonary space-occupying lesions, and parenchymal infiltrative lesions) conspicuity, and beam-hardening artifacts. The objective quality included the measurement of noise in the left ventricle and back muscle to calculate signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of ventricle.

Results

There was no difference in radiation dose between the study (CTDIvol of 1.79 ± 1.45 mGy) and control (1.68 ± 0.92 mGy) groups (p = 0.65). However, the study group used 19.7% lower CM dose than the control group (5.84 ± 2.69 vs. 7.27 ± 3.80 gI), and the enhancement in all images met the diagnostic requirements. MBIR reduced image noise by 58.6% and increased SNR and CNR by 143.6% and 165.7%, respectively, compared to ASIR images in the control group. The two ASIR image sets had similar image quality.

Conclusion

MBIR improved the image quality of low-radiation-dose chest CT in children at 19.3% reduced CM dose.

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Birdseed Food Co. Issues Allergy Alert on Undeclared Cashews in Craft Granola Goldenola Turmeric & Ginger

BIRDSEED FOOD CO. of Bend, OR is recalling Craft Granola Goldenola Turmeric& Ginger that was sold between the dates of 10/03/18 - 02/07/19, because it contains undeclared cashews. People who have an allergy or severe sensitivity to cashews run the risk of serious or life-threatening allergic reaction if they consume this product. (Source: Food and Drug Administration)

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Dental injuries in patients associated with fracture of facial bones

Abstract

Purpose

To assess different types of dental injuries associated with facial bone fractures.

Method

One hundred dentate patients were selected randomly of all age and gender who had maxillofacial trauma only and having dental injury in association with facial bones fractures were included. They were thoroughly examined for injury/fracture to facial region as well as for dental injuries (teeth). Tooth injuries were noted according to Ellis classification. The data was collected, compiled, and put to statistical analysis.

Results

Dental injuries were more in females than males found to be statistically significant with (p < 0.05).Crown fracture of maxillary teeth was more as compared to mandibular except molars found to be statistically significant (p < 0.05). Root fracture was more in maxillary incisors followed by canine as compared to mandibular incisors and canines found to be insignificant. Avulsion, extrusion and luxation were more in maxilla as compared to mandible found to be significant.

Conclusion

Different types of tooth injuries associated with facial bone fracture found more in females and maxillary teeth.

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Eosinophil Peroxidase, GATA3 and T-bet as Tissue Biomarkers in Chronic Rhinosinusitis

Eosinophil peroxidase is a potential biomarker for eosinophilic chronic rhinosinusitis. Th2/Th1 polarization, as measured by GATA3 and T-bet, was not associated with eosinophilia or any clinical or histopathologic feature of chronic rhinosinusitis. (Source: Journal of Allergy and Clinical Immunology)

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Montelukast does not increase the risk of neuropsychiatric disease in children with asthma: a nationwide population-based cohort study

Montelukast, a leukotriene receptor antagonist, is one of the most common medication used in childhood asthma. Since March 2008, there have been concerns about a possible risk of neuropsychiatric disease during Montelukast use, However, former conflicting evidence bothered both clinicians and parents of children with asthma. We thought to examine whether Montelukast intervention in asthmatic children is associated with an increased risk of neuropsychiatric disease. (Source: Journal of Allergy and Clinical Immunology)

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Physician and Parent Comfort, Awareness, Barriers, and Implementation of the Guidelines for the Prevention of Peanut Allergy

Utilization of the NIAID-sponsored Expert Panel Guidelines for preventing peanut allergy is under-studied, so we explored stakeholder views. (Source: Journal of Allergy and Clinical Immunology)

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Differences in Failed Oral Food Challenges Among Five Common Tree Nuts in Children

This study aims to provide insight into the proportion of failed OFC among common tree nuts. (Source: Journal of Allergy and Clinical Immunology)

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Comparison of Different Criteria for the Evaluation of Allergic Rhinitis Control in Adolescents

The objective was to evaluate the specificities of different methods for clinical control of AR. (Source: Journal of Allergy and Clinical Immunology)

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Safety Of 300IR 5-Grass Tablet In Grass Pollen –Allergic Children With Or Without Controlled Asthma: Further Data From A Post-Marketing Observational Study

We report safety data of 300IR 5-grass tablet* for patient subgroups with/without controlled asthma in a post-marketing study of children (aged 5-9 years) with grass pollen –induced allergic rhinitis/rhinoconjunctivitis (GP-AR). (Source: Journal of Allergy and Clinical Immunology)

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Impact of a Self-management Support Intervention for Older Adults with Asthma on Use of Controller Medications and Emergency Department Visits

Older asthmatics often have poor outcomes stemming from problems with illness self-management, yet few studies of asthma self-management support (SMS) for older adults have been reported. (Source: Journal of Allergy and Clinical Immunology)

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Chart Review to Evaluate Co-Sensitization Between Cashew and Sesame

In the USA, the diagnosis of tree nut and seed allergy appears to have increased in recent years. An association between tree nut and sesame allergy has been observed, and we noticed a particular association between cashew and sesame allergy. We sought to investigate this further. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BraySy

Real World Data Of Canadians Living With Hereditary Angioedema: Part 1- Demographics

Hereditary angioedema (HAE) is an unpredictable and serious genetic disorder affecting approximately 1:10,000 to 1:50,000. Clinically, it is manifested by painful, unpredictable edema of the face, larynx, abdomen, genitals and extremities. We sought to better understand the demographic profiles of Canadians living with HAE. (Source: Journal of Allergy and Clinical Immunology)

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A Volumetric Survey of Aeroallergens in San Antonio, Texas From 2012-2017: Not All Allergens Fit The Mold

An aeroallergen survey of Texas trees, weeds and grasses does not exist. This is the first survey of the unique pollinating patterns in San Antonio, TX developed to tailor testing and immunotherapy. (Source: Journal of Allergy and Clinical Immunology)

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Eosinophil Peroxidase, GATA3 and T-bet as Tissue Biomarkers in Chronic Rhinosinusitis

Eosinophil peroxidase is a potential biomarker for eosinophilic chronic rhinosinusitis. Th2/Th1 polarization, as measured by GATA3 and T-bet, was not associated with eosinophilia or any clinical or histopathologic feature of chronic rhinosinusitis. (Source: Journal of Allergy and Clinical Immunology)

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Histamine-driven responses are sustained via a bioactive metabolite

A histamine metabolite, imidazole acetic acid (IAA), recapitulates key histamine-driven biology, including recruitment of eosinophils, induction of itch, and induction of anaphylaxis. IAA may perpetuate anaphylactic and other allergic responses after the initial release and metabolism of histamine. (Source: Journal of Allergy and Clinical Immunology)

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Montelukast does not increase the risk of neuropsychiatric disease in children with asthma: a nationwide population-based cohort study

Montelukast, a leukotriene receptor antagonist, is one of the most common medication used in childhood asthma. Since March 2008, there have been concerns about a possible risk of neuropsychiatric disease during Montelukast use, However, former conflicting evidence bothered both clinicians and parents of children with asthma. We thought to examine whether Montelukast intervention in asthmatic children is associated with an increased risk of neuropsychiatric disease. (Source: Journal of Allergy and Clinical Immunology)

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Evidence for Twice-Daily Nasal Steroids Versus Once Daily for Treatment of Chronic Rhinosinusitis with Nasal Polyps

Nasal steroids are first-line treatment for chronic rhinosinusitis (CRS), with nasal polyps. Some physicians prescribe once-daily (QD) regimens and some twice-daily (BID). This literature review compares once- vs twice-daily dosing. (Source: Journal of Allergy and Clinical Immunology)

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Physician and Parent Comfort, Awareness, Barriers, and Implementation of the Guidelines for the Prevention of Peanut Allergy

Utilization of the NIAID-sponsored Expert Panel Guidelines for preventing peanut allergy is under-studied, so we explored stakeholder views. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bra7ro

Differences in Failed Oral Food Challenges Among Five Common Tree Nuts in Children

This study aims to provide insight into the proportion of failed OFC among common tree nuts. (Source: Journal of Allergy and Clinical Immunology)

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The Efficacy of Walnut IgE Component Testing in Determining Walnut Sensitivity

Prior studies indicate that walnut component testing (WCT) may serve as a better indicator for clinical reactivity than skin prick (SPT) and walnut-specific IgE testing (wIgE) in patients with birch pollen allergy. The efficacy of WCT in determining clinical reactivity represents a potential gap in clinical management. (Source: Journal of Allergy and Clinical Immunology)

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Comparison of Different Criteria for the Evaluation of Allergic Rhinitis Control in Adolescents

The objective was to evaluate the specificities of different methods for clinical control of AR. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TJCDvu

Impact of electronic health record transition on drug allergy labels: gains, losses, alterations and learning opportunities

Maintenance of accurate drug allergy labels is critical to the safety and efficacy of future treatment choices. We assessed the accuracy and quality of drug allergy label transfer during the implementation of a simultaneous inpatient and outpatient electronic health record (EHR) transition. (Source: Journal of Allergy and Clinical Immunology)

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Possible sources of Bermuda sensitization in Timothy grass allergic subjects

Timothy and Bermuda grasses are associated with allergic rhinitis and asthma, worldwide. Timothy grass flourishes in temperate climates in northern parts of North America and Europe. Alternatively, Bermuda grass is a sub-tropical lawn grass and a widespread allergen in the southern United States. Although exposure to Bermuda grass in Ontario is non-existent due to the colder temperatures, we have observed a high frequency of skin sensitization to both grasses. We sought to investigate routes of sensitization to Bermuda grass in individuals with a positive skin-prick test to both Bermuda and Timothy grass. (Source: Journal of Allergy and Clinical Immunology)

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TGF- β present in breast milk is biologically active to induce IgA production in B-cells

The role of human breast milk in protection against allergic diseases is debated and the mechanisms are unknown. While breast milk is known to confer passive immunity to the infant in the first weeks of life, little is known regarding its effect on induction of IgA class switch recombination (CSR) through cytokines, including TGF- β and APRIL, found in large quantities in breast milk. (Source: Journal of Allergy and Clinical Immunology)

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Safety Of 300IR 5-Grass Tablet In Grass Pollen –Allergic Children With Or Without Controlled Asthma: Further Data From A Post-Marketing Observational Study

We report safety data of 300IR 5-grass tablet* for patient subgroups with/without controlled asthma in a post-marketing study of children (aged 5-9 years) with grass pollen –induced allergic rhinitis/rhinoconjunctivitis (GP-AR). (Source: Journal of Allergy and Clinical Immunology)

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Food Protein Induced Enterocolitis Syndrome (FPIES): Data from a Tertiary Care Center in Developing Country

Food Protein Induced Enterocolitis Syndrome (FPIES) is a non –IgE-mediated food allergy. In developing countries, FPIES may be under-recognized and misdiagnosed as gastrointestinal infection. We sought to characterize the clinical features of FPIES in a tertiary care center in Thailand. (Source: Journal of Allergy and Clinical Immunology)

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Impact of a Self-management Support Intervention for Older Adults with Asthma on Use of Controller Medications and Emergency Department Visits

Older asthmatics often have poor outcomes stemming from problems with illness self-management, yet few studies of asthma self-management support (SMS) for older adults have been reported. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TJCsQQ

Chart Review to Evaluate Co-Sensitization Between Cashew and Sesame

In the USA, the diagnosis of tree nut and seed allergy appears to have increased in recent years. An association between tree nut and sesame allergy has been observed, and we noticed a particular association between cashew and sesame allergy. We sought to investigate this further. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BraySy

The effect of muscarinic M3 receptor blockage in development of M2 macrophages in allergic inflammation

We have reported that muscarinic M3 receptor antagonist (tiotropium) inhibits the allergic airway inflammation in murine model of asthma. However, the mechanism is still unclear. The purpose of this study is to investigate the effect of muscarinic M3 receptor blockage in development of M2 macrophages in allergic inflammation. (Source: Journal of Allergy and Clinical Immunology)

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Development of an in Vitro Bio-Assay Using Human Intestinal and Immune Cell-Lines to Measure the Immuno-Pathogenicity of Food Allergens

Food allergies are a rapidly growing public health problem that affect>15 million Americans. The FDA 's Food Allergen Labeling and Consumer Protection Act requires that foods containing allergenic proteins derived from the eight major food allergens be declared. The currently used Immunochemical methods (e.g. ELISA) detect IgG antigenic epitopes, and not allergenic elements. Hence, immunochemical methods may not detect antigenic epitopes that are transformed during food processing, while the immuno-pathogenicity could continue to persist. (Source: Journal of Allergy and Clinical Immunology)

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Real World Data Of Canadians Living With Hereditary Angioedema: Part 1- Demographics

Hereditary angioedema (HAE) is an unpredictable and serious genetic disorder affecting approximately 1:10,000 to 1:50,000. Clinically, it is manifested by painful, unpredictable edema of the face, larynx, abdomen, genitals and extremities. We sought to better understand the demographic profiles of Canadians living with HAE. (Source: Journal of Allergy and Clinical Immunology)

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Chromobox Protein-7 (CBX7), a Polycomb Group Repressor, Functions as a Transcriptional Co-activator of Type 2 Cytokine Genes in Lymphoid Cells and is Important for Asthma

CBX7 is a H3K27 methyl reader and a polycomb repressor complex-1 (PRC1) member. Its role in cytokine gene expression is unknown. (Source: Journal of Allergy and Clinical Immunology)

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A Volumetric Survey of Aeroallergens in San Antonio, Texas From 2012-2017: Not All Allergens Fit The Mold

An aeroallergen survey of Texas trees, weeds and grasses does not exist. This is the first survey of the unique pollinating patterns in San Antonio, TX developed to tailor testing and immunotherapy. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TE836k

Birdseed Food Co. Issues Allergy Alert on Undeclared Cashews in Craft Granola Goldenola Turmeric & Ginger

BIRDSEED FOOD CO. of Bend, OR is recalling Craft Granola Goldenola Turmeric& Ginger that was sold between the dates of 10/03/18 - 02/07/19, because it contains undeclared cashews. People who have an allergy or severe sensitivity to cashews run the risk of serious or life-threatening allergic reaction if they consume this product. (Source: Food and Drug Administration)

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Ectoine lozenges in the treatment of acute viral pharyngitis: a prospective, active-controlled clinical study

Abstract

Purpose

Acute pharyngitis is an uncomfortable disorder mostly caused by viruses and for which antibiotics are unwarranted. This study compared lozenges containing ectoine, a natural extremolyte, with hyaluronic acid lozenges and hypertonic saline gargle for symptomatic treatment of acute viral pharyngitis.

Methods

This prospective, controlled clinical study, recruited 90 patients with moderate-to-severe pharyngitis symptoms who chose to use either ectoine (n = 35), hyaluronic acid (n = 35), or saline gargle (n = 20). Patients applied their 7-day treatment from the inclusion visit (V1) until the end-of-study visit (V2). Patients' pharyngitis symptoms, general health, general treatment effectiveness and tolerability, and patient compliance were assessed by investigators and patients.

Results

The sum score for three primary symptoms (pain on swallowing, urge to cough, and hoarseness) decreased by 79.5% (ectoine), 72.2% (hyaluronic acid), and 44.8% (saline gargle). Both lozenges were significantly superior to saline gargle (P < 0.05). Regarding general health improvement, ectoine was significantly superior to saline gargle (72.5% vs. 45.2%, P < 0.05), but hyaluronic acid (63.3%) was not. At V2, 65.7% of patients receiving ectoine reported "very good" general health vs. 48.6% of those receiving hyaluronic acid and 20.0% using saline gargle. Ectoine was significantly superior (P < 0.05) to both hyaluronic acid and saline gargle in terms of tolerability and patient compliance. No patients taking ectoine reported unpleasant sensations while applying their treatment, whereas almost half of patients using hyaluronic acid lozenges and saline gargle did.

Conclusion

Treatment with ectoine lozenges significantly relieves moderate-to-severe symptoms of acute viral pharyngitis and is more effective and tolerable than treatments with hyaluronic acid lozenges and hypertonic saline gargle.

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Ectoine lozenges in the treatment of acute viral pharyngitis: a prospective, active-controlled clinical study

Abstract

Purpose

Acute pharyngitis is an uncomfortable disorder mostly caused by viruses and for which antibiotics are unwarranted. This study compared lozenges containing ectoine, a natural extremolyte, with hyaluronic acid lozenges and hypertonic saline gargle for symptomatic treatment of acute viral pharyngitis.

Methods

This prospective, controlled clinical study, recruited 90 patients with moderate-to-severe pharyngitis symptoms who chose to use either ectoine (n = 35), hyaluronic acid (n = 35), or saline gargle (n = 20). Patients applied their 7-day treatment from the inclusion visit (V1) until the end-of-study visit (V2). Patients' pharyngitis symptoms, general health, general treatment effectiveness and tolerability, and patient compliance were assessed by investigators and patients.

Results

The sum score for three primary symptoms (pain on swallowing, urge to cough, and hoarseness) decreased by 79.5% (ectoine), 72.2% (hyaluronic acid), and 44.8% (saline gargle). Both lozenges were significantly superior to saline gargle (P < 0.05). Regarding general health improvement, ectoine was significantly superior to saline gargle (72.5% vs. 45.2%, P < 0.05), but hyaluronic acid (63.3%) was not. At V2, 65.7% of patients receiving ectoine reported "very good" general health vs. 48.6% of those receiving hyaluronic acid and 20.0% using saline gargle. Ectoine was significantly superior (P < 0.05) to both hyaluronic acid and saline gargle in terms of tolerability and patient compliance. No patients taking ectoine reported unpleasant sensations while applying their treatment, whereas almost half of patients using hyaluronic acid lozenges and saline gargle did.

Conclusion

Treatment with ectoine lozenges significantly relieves moderate-to-severe symptoms of acute viral pharyngitis and is more effective and tolerable than treatments with hyaluronic acid lozenges and hypertonic saline gargle.

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Arnold Shkolnik, MD (1930–2018)

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Arnold Shkolnik, MD (1930–2018)

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Polymerization pattern characterization within a resin-based composite cured using different curing units at two distances

Abstract

Objectives

To investigate the relationship of the irradiance-beam-profile areas from six different light-curing units (LCUs) with the degree of conversion (DC), microhardness (KH), and cross-link density (CLD) throughout a resin-based composite (RBC) cured at two clinically relevant distances, and to explore the correlations among them.

Materials and methods

A mapping approach was used to measure DC using micro-Raman spectroscopy, KH using a Knoop indentor on a hardness tester, and %KH reduction after ethanol exposure, as an indicator for CLD within a nano-hybrid RBC increment (n = 3) at various depths. These sample composites were cured from two distances while maintaining the radiant exposure, using six different light-curing units: one quartz-tungsten-halogen; two single and three multiple-emission-peak light-emitting-diode units. Irradiance beam profiles were generated for each LCU at both distances, and localized irradiance values were calculated. Points across each depth were analyzed using repeated measures ANOVA. Correlations across multiple specimen locations and associations between beam uniformity corresponding with polymerization measurements were calculated using linear mixed models and Pearson correlation coefficients.

Results

Significant non-uniform polymerization patterns occurred within the specimens at various locations and depths. At 2-mm curing distance, the localized DC = 52.7–76.8%, KH = 39.0–66.7 kg/mm², and %KH reduction = 26.7–57.9%. At 8-mm curing distance, the localized DC = 50.4–78.6%, KH = 40.3–73.7 kg/mm², and %KH reduction = 28.2–56.8%. The localized irradiance values were weakly correlated with the corresponding DC, KH, and %KH reduction, with only a few significant correlations (p < 0.05).

Conclusions

Although significant differences were observed at each depth within the specimens, the localized irradiance values for all LCUs did not reflect the polymerization pattern and did not seem to have a major influence on polymerization patterns within the RBC, regardless of the curing distance.

Clinical relevance

Commonly used LCUs do not produce uniform polymerization regardless of the curing distance, which may contribute to the risk of RBC fracture.

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Visibility, location, and morphology of the primary maxillary sinus ostium and presence of accessory ostia: a retrospective analysis using cone beam computed tomography (CBCT)

Abstract

Objectives

This retrospective study evaluated the visibility, location, and morphology of the primary maxillary ostium (PMO), as well as the presence and number of accessory maxillary ostia (AMO) in the maxillary sinus using cone beam computed tomography (CBCT).

Materials and methods

CBCT scans with a large field of view with both maxillary sinuses entirely visible, acquired from February 2016 to February 2018, were initially screened. Patients were included if there was no history of surgical intervention/trauma in the sinus region. Two observers evaluated the CBCTs for PMO and AMOs independently. PMO and AMOs were evaluated in axial, coronal, and sagittal CBCT views. In case of disagreement, a third observer served as a referee. The findings were correlated with age, gender, condition of the sinus mucosa, and status of the dentition to assess for potential influencing factors.

Results

A total of 184 patients (368 maxillary sinuses) were included. PMO was present and patent in 346 (94.0%) of the 368 analyzed sinuses. Most of the PMOs were located above the attachment of and in the middle third of the inferior turbinate (76.1%) and exhibited a slit shape (71.1%). An AMO was present in 167 (45.5%) of the 368 analyzed sinuses, and 66 (17.9%) sinuses had multiple AMOs. Gender and sinus mucosa morphology were found to be influencing factors for the patency of the PMO. Furthermore, gender seems to be influencing the presence of an AMO.

Conclusions

Most of the analyzed maxillary sinus cavities in the present population had a patent PMO. Being male and having morphological changes of the sinus mucosa were factors associated with a reduced prevalence of a patent PMO.

Clinical relevance

A maxillary sinus with pathological findings of the mucosa seems to have a reduced prevalence of patent PMOs. Therefore, clinicians should take care to assess any clinical and radiographical sign indicating a potential maxillary sinusitis prior to surgical interventions in this region, especially in cases with planned sinus floor elevation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RPBKzo

Polymerization pattern characterization within a resin-based composite cured using different curing units at two distances

Abstract

Objectives

To investigate the relationship of the irradiance-beam-profile areas from six different light-curing units (LCUs) with the degree of conversion (DC), microhardness (KH), and cross-link density (CLD) throughout a resin-based composite (RBC) cured at two clinically relevant distances, and to explore the correlations among them.

Materials and methods

A mapping approach was used to measure DC using micro-Raman spectroscopy, KH using a Knoop indentor on a hardness tester, and %KH reduction after ethanol exposure, as an indicator for CLD within a nano-hybrid RBC increment (n = 3) at various depths. These sample composites were cured from two distances while maintaining the radiant exposure, using six different light-curing units: one quartz-tungsten-halogen; two single and three multiple-emission-peak light-emitting-diode units. Irradiance beam profiles were generated for each LCU at both distances, and localized irradiance values were calculated. Points across each depth were analyzed using repeated measures ANOVA. Correlations across multiple specimen locations and associations between beam uniformity corresponding with polymerization measurements were calculated using linear mixed models and Pearson correlation coefficients.

Results

Significant non-uniform polymerization patterns occurred within the specimens at various locations and depths. At 2-mm curing distance, the localized DC = 52.7–76.8%, KH = 39.0–66.7 kg/mm², and %KH reduction = 26.7–57.9%. At 8-mm curing distance, the localized DC = 50.4–78.6%, KH = 40.3–73.7 kg/mm², and %KH reduction = 28.2–56.8%. The localized irradiance values were weakly correlated with the corresponding DC, KH, and %KH reduction, with only a few significant correlations (p < 0.05).

Conclusions

Although significant differences were observed at each depth within the specimens, the localized irradiance values for all LCUs did not reflect the polymerization pattern and did not seem to have a major influence on polymerization patterns within the RBC, regardless of the curing distance.

Clinical relevance

Commonly used LCUs do not produce uniform polymerization regardless of the curing distance, which may contribute to the risk of RBC fracture.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WRehBP

Visibility, location, and morphology of the primary maxillary sinus ostium and presence of accessory ostia: a retrospective analysis using cone beam computed tomography (CBCT)

Abstract

Objectives

This retrospective study evaluated the visibility, location, and morphology of the primary maxillary ostium (PMO), as well as the presence and number of accessory maxillary ostia (AMO) in the maxillary sinus using cone beam computed tomography (CBCT).

Materials and methods

CBCT scans with a large field of view with both maxillary sinuses entirely visible, acquired from February 2016 to February 2018, were initially screened. Patients were included if there was no history of surgical intervention/trauma in the sinus region. Two observers evaluated the CBCTs for PMO and AMOs independently. PMO and AMOs were evaluated in axial, coronal, and sagittal CBCT views. In case of disagreement, a third observer served as a referee. The findings were correlated with age, gender, condition of the sinus mucosa, and status of the dentition to assess for potential influencing factors.

Results

A total of 184 patients (368 maxillary sinuses) were included. PMO was present and patent in 346 (94.0%) of the 368 analyzed sinuses. Most of the PMOs were located above the attachment of and in the middle third of the inferior turbinate (76.1%) and exhibited a slit shape (71.1%). An AMO was present in 167 (45.5%) of the 368 analyzed sinuses, and 66 (17.9%) sinuses had multiple AMOs. Gender and sinus mucosa morphology were found to be influencing factors for the patency of the PMO. Furthermore, gender seems to be influencing the presence of an AMO.

Conclusions

Most of the analyzed maxillary sinus cavities in the present population had a patent PMO. Being male and having morphological changes of the sinus mucosa were factors associated with a reduced prevalence of a patent PMO.

Clinical relevance

A maxillary sinus with pathological findings of the mucosa seems to have a reduced prevalence of patent PMOs. Therefore, clinicians should take care to assess any clinical and radiographical sign indicating a potential maxillary sinusitis prior to surgical interventions in this region, especially in cases with planned sinus floor elevation.

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Chronic Rhinosinusitis May Up Risk for Anxiety, Depression Chronic Rhinosinusitis May Up Risk for Anxiety, Depression

Chronic rhinosinusitis is associated with increased risk for anxiety and depression. An expert says possible causal links are unclear, but he supports mental health screening for these patients.Medscape Medical News (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tadRsA

Chronic Rhinosinusitis May Up Risk for Anxiety, Depression Chronic Rhinosinusitis May Up Risk for Anxiety, Depression

Chronic rhinosinusitis is associated with increased risk for anxiety and depression. An expert says possible causal links are unclear, but he supports mental health screening for these patients.Medscape Medical News (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tadRsA

Expectations and Experience of Children with Unilateral Cochlear Implantation: A Parental Perspective

Abstract

To find out parental expectations regarding outcomes of unilateral cochlear implantation prior to surgery and experience received by them after cochlear implantation and 1 year of regular auditory verbal therapy, with respect to the communication abilities, social skills and participation. Total of 200 parents of hearing impaired children participated in the study. A closed ended questionnaire containing 13 questions were used to collect the data. The participants were instructed to complete all the questions provided based on their expectations and experiences. The descriptive statistics were used to determine the frequency and percentage. Among 200 parents, almost all (95%) of the parents expected to have improvement in all the subscale of communication abilities, social skills and participation. 68.5% of the parents experienced improvement in their child's communication abilities, such as, response to quiet sounds, repetition of words without seeing speaker's face, elimination of use of gestures, easy communication and verbal expression for needs, thoughts and feelings. 76% of the parents experienced improvement in social skills and participations, such as, good relationship with elders, siblings and peers, making friends outside the family, actively participating in the activity done by other children and easily accepted by peers in the classroom. A large number of parents met with their expectations and a small proportion of families were found to be disappointed due to high hopes and unrealistic expectation before implantation, which had adverse effect on the children's performance.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SJDfUi

Expectations and Experience of Children with Unilateral Cochlear Implantation: A Parental Perspective

Abstract

To find out parental expectations regarding outcomes of unilateral cochlear implantation prior to surgery and experience received by them after cochlear implantation and 1 year of regular auditory verbal therapy, with respect to the communication abilities, social skills and participation. Total of 200 parents of hearing impaired children participated in the study. A closed ended questionnaire containing 13 questions were used to collect the data. The participants were instructed to complete all the questions provided based on their expectations and experiences. The descriptive statistics were used to determine the frequency and percentage. Among 200 parents, almost all (95%) of the parents expected to have improvement in all the subscale of communication abilities, social skills and participation. 68.5% of the parents experienced improvement in their child's communication abilities, such as, response to quiet sounds, repetition of words without seeing speaker's face, elimination of use of gestures, easy communication and verbal expression for needs, thoughts and feelings. 76% of the parents experienced improvement in social skills and participations, such as, good relationship with elders, siblings and peers, making friends outside the family, actively participating in the activity done by other children and easily accepted by peers in the classroom. A large number of parents met with their expectations and a small proportion of families were found to be disappointed due to high hopes and unrealistic expectation before implantation, which had adverse effect on the children's performance.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SJDfUi

Chronic Rhinosinusitis May Up Risk for Anxiety, Depression Chronic Rhinosinusitis May Up Risk for Anxiety, Depression

Chronic rhinosinusitis is associated with increased risk for anxiety and depression. An expert says possible causal links are unclear, but he supports mental health screening for these patients.Medscape Medical News (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tadRsA

Chronic Rhinosinusitis May Up Risk for Anxiety, Depression Chronic Rhinosinusitis May Up Risk for Anxiety, Depression

Chronic rhinosinusitis is associated with increased risk for anxiety and depression. An expert says possible causal links are unclear, but he supports mental health screening for these patients.Medscape Medical News (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tadRsA

The prevalence of hearing loss and use of hearing aids among adults in Germany: a systematic review

Abstract

Background

Worldwide approximately 360 million people suffer from hearing impairment, 328 million of whom are adults. Up to now there has been no systematic evaluation of any representative epidemiological data on the prevalence of hearing loss among adults in Germany. The present paper is intended to investigate this within the framework of a systematic review.

Methods

A systematic literature search was carried out in electronic databases as well as by means of hand-searching. Studies published after 1975 and indicating the prevalence or incidence of hearing impairment among German adults were included. Study selection, data extraction and additional quality assessments were made by two independent reviewers.

Results

By means of a systematic literature search it was possible to identify 6 sources, which provided solely cross-sectional data, whereby the reported data are based on a study population of between some hundred and 10 million people living in Germany. The prevalences ascertained showed a broad range of between 16% and 25% and varied according to age, study setting, definition of hearing loss and method of data capture. At present there are no utilizable data on the extent of the use of hearing aids.

Discussion

The present review demonstrates clearly that evidence-based information relating to Germany can only be made on the basis of a clear definition of hearing loss within the framework of an up-to-date and representative epidemiological study carried out with appropriate methodology. In view of the high prevalence of illnesses causing hearing impairment and of the risks to health associated with untreated hearing impairment as well as of socio-economic costs, such an epidemiological study is of great social significance.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UNmWmQ

The prevalence of hearing loss and use of hearing aids among adults in Germany: a systematic review

Abstract

Background

Worldwide approximately 360 million people suffer from hearing impairment, 328 million of whom are adults. Up to now there has been no systematic evaluation of any representative epidemiological data on the prevalence of hearing loss among adults in Germany. The present paper is intended to investigate this within the framework of a systematic review.

Methods

A systematic literature search was carried out in electronic databases as well as by means of hand-searching. Studies published after 1975 and indicating the prevalence or incidence of hearing impairment among German adults were included. Study selection, data extraction and additional quality assessments were made by two independent reviewers.

Results

By means of a systematic literature search it was possible to identify 6 sources, which provided solely cross-sectional data, whereby the reported data are based on a study population of between some hundred and 10 million people living in Germany. The prevalences ascertained showed a broad range of between 16% and 25% and varied according to age, study setting, definition of hearing loss and method of data capture. At present there are no utilizable data on the extent of the use of hearing aids.

Discussion

The present review demonstrates clearly that evidence-based information relating to Germany can only be made on the basis of a clear definition of hearing loss within the framework of an up-to-date and representative epidemiological study carried out with appropriate methodology. In view of the high prevalence of illnesses causing hearing impairment and of the risks to health associated with untreated hearing impairment as well as of socio-economic costs, such an epidemiological study is of great social significance.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UNmWmQ

Comment on “Nonsurgical Management of Medication-Related Osteonecrosis of the Jaws Using Local Wound Care” by Hadaya et al

We read with great interest the article by Hadaya et al,1 who used a novel nonsurgical treatment for patients with medication-related osteonecrosis of the jaw (MRONJ) and reported much a higher healing rate in patients (71%) compared with the healing rate obtained in a multicenter retrospective study (25.2%).2 However, according to other recent articles, the surgical treatment of patients with MRONJ is more effective than nonsurgical treatment.2,3 In addition, extensive surgery in combination with well-vascularized flaps dramatically improved the healing rate in patients with MRONJ.

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Comment on “Nonsurgical Management of Medication-Related Osteonecrosis of the Jaws Using Local Wound Care” by Hadaya et al

We read with great interest the article by Hadaya et al,1 who used a novel nonsurgical treatment for patients with medication-related osteonecrosis of the jaw (MRONJ) and reported much a higher healing rate in patients (71%) compared with the healing rate obtained in a multicenter retrospective study (25.2%).2 However, according to other recent articles, the surgical treatment of patients with MRONJ is more effective than nonsurgical treatment.2,3 In addition, extensive surgery in combination with well-vascularized flaps dramatically improved the healing rate in patients with MRONJ.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2E1GC0M

Comment on “Nonsurgical Management of Medication-Related Osteonecrosis of the Jaws Using Local Wound Care” by Hadaya et al

We read with great interest the article by Hadaya et al,1 who used a novel nonsurgical treatment for patients with medication-related osteonecrosis of the jaw (MRONJ) and reported much a higher healing rate in patients (71%) compared with the healing rate obtained in a multicenter retrospective study (25.2%).2 However, according to other recent articles, the surgical treatment of patients with MRONJ is more effective than nonsurgical treatment.2,3 In addition, extensive surgery in combination with well-vascularized flaps dramatically improved the healing rate in patients with MRONJ.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2E1GC0M

How I Learned to Embrace Technology in a School-Based Setting

Let's face it: Technology makes everything easier. But what are students really learning when they use apps or online games? And what is the best way to target speech and language goals using tech? I interned during the 2017–-2018 school year as a student speech-language pathologist at an elementary school for K–5 students. All the sweet children I saw loved technology, having been born into a digital world. Our main source of technology at this school was a single tablet specific for the speech-language pathology department. This tablet had tons of apps, some for articulation, some for language and some for educational games. As a student intern, I believed using technology during sessions was an "easy way out." (Of course, this belief excluded students working with augmentativ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WRw5wD

Comment on “Nonsurgical Management of Medication-Related Osteonecrosis of the Jaws Using Local Wound Care” by Hadaya et al

We read with great interest the article by Hadaya et al,1 who used a novel nonsurgical treatment for patients with medication-related osteonecrosis of the jaw (MRONJ) and reported much a higher healing rate in patients (71%) compared with the healing rate obtained in a multicenter retrospective study (25.2%).2 However, according to other recent articles, the surgical treatment of patients with MRONJ is more effective than nonsurgical treatment.2,3 In addition, extensive surgery in combination with well-vascularized flaps dramatically improved the healing rate in patients with MRONJ.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2E1GC0M

How I Learned to Embrace Technology in a School-Based Setting

Let's face it: Technology makes everything easier. But what are students really learning when they use apps or online games? And what is the best way to target speech and language goals using tech? I interned during the 2017–-2018 school year as a student speech-language pathologist at an elementary school for K–5 students. All the sweet children I saw loved technology, having been born into a digital world. Our main source of technology at this school was a single tablet specific for the speech-language pathology department. This tablet had tons of apps, some for articulation, some for language and some for educational games. As a student intern, I believed using technology during sessions was an "easy way out." (Of course, this belief excluded students working with augmentativ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WRw5wD

How I Learned to Embrace Technology in a School-Based Setting

Let's face it: Technology makes everything easier. But what are students really learning when they use apps or online games? And what is the best way to target speech and language goals using tech? I interned during the 2017–-2018 school year as a student speech-language pathologist at an elementary school for K–5 students. All the sweet children I saw loved technology, having been born into a digital world. Our main source of technology at this school was a single tablet specific for the speech-language pathology department. This tablet had tons of apps, some for articulation, some for language and some for educational games. As a student intern, I believed using technology during sessions was an "easy way out." (Of course, this belief excluded students working with augmentativ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WRw5wD

How I Learned to Embrace Technology in a School-Based Setting

Let's face it: Technology makes everything easier. But what are students really learning when they use apps or online games? And what is the best way to target speech and language goals using tech? I interned during the 2017–-2018 school year as a student speech-language pathologist at an elementary school for K–5 students. All the sweet children I saw loved technology, having been born into a digital world. Our main source of technology at this school was a single tablet specific for the speech-language pathology department. This tablet had tons of apps, some for articulation, some for language and some for educational games. As a student intern, I believed using technology during sessions was an "easy way out." (Of course, this belief excluded students working with augmentativ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WRw5wD

Nachruf Prof. Dr. Heinz R. Stammberger

Laryngo-Rhino-Otol 2019; 98: 76-76
DOI: 10.1055/a-0828-5454

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Kehlkopf-Karzinom: Wundbettbiopsien nach TLM-Behandlung sinnvoll

Laryngo-Rhino-Otol 2019; 98: 71-72
DOI: 10.1055/a-0785-0981

Hendriksma M et al. Evaluation of surgical margin status in patients with early glottic cancer (Tis-T2) treated with transoral CO2 laser microsurgery, on local control. Eur Arch Otorhinolaryngol 2018; 275: 2333–2340 Bei Patienten mit primärem Kehlkopf-Plattenepithelkarzinom (Tis-T2) beurteilten niederländische Kopf- und Hals-Chirurgen den Effekt des Resektionsrand-Status auf die lokale Kontrollrate nach Behandlung mit transoraler CO2-Laser-Mikrochirurgie (TLM). Darüber hinaus überprüften die Bedeutung zusätzlicher Wundbettbiopsien.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2I2G2Eh

Assoziation von allergischer Rhinitis und Hypertonie untersucht

Laryngo-Rhino-Otol 2019; 98: 74-75
DOI: 10.1055/a-0651-4041

Sakallioglu O et al. Allergic rhinitis and arterial blood pressure: a population-based study. J Laryngol Otol 2018; 132: 418–422 Gibt es einen Zusammenhang von allergischer Rhinitis und arteriellem Blutdruck sowie Bluthochdruck? In einer bevölkerungsbasierten Untersuchung wollten türkische Ärzte diese Frage klären.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GiMftI

Spiegeluntersuchung in der HNO

Laryngo-Rhino-Otol 2019; 98: 77-78
DOI: 10.1055/a-0784-9833

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Mindestmengen: Die Qual der Zahl oder Mittel der Qualitätssicherung?

Laryngo-Rhino-Otol 2019; 98: 114-116
DOI: 10.1055/a-0784-9855

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Fragen für die Facharztprüfung

Laryngo-Rhino-Otol 2019; 98: 129-130
DOI: 10.1055/a-0784-9866

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Erratum: Stellenwert der Sialendoskopie an deutschen HNO-Kliniken im Jahr 2016

Laryngo-Rhino-Otol 2019; 98: E1-E1
DOI: 10.1055/a-0849-2046

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

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Fehlbildungschirurgie von Nase und Lippe

Laryngo-Rhino-Otol 2019; 98: 131-133
DOI: 10.1055/a-0784-9910

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Sonografie von Schilddrüsenknoten

Laryngo-Rhino-Otol 2019; 98: 79-84
DOI: 10.1055/a-0790-0849

Die Sonografie gehört zu den Standardverfahren bei der Evaluation von Schilddrüsenknoten. Verschiedene sonografische Veränderungen sind mit einem erhöhten Malignitätsrisiko assoziiert. Basierend hierauf wurden in den letzten Jahren Klassifizierungssysteme entwickelt, um leichter diejenigen Knoten zu selektieren, welche einer weiteren Abklärung bedürfen (TI-RADS: thyroid imaging and reporting systems). Bis jetzt werden in diesen Systemen nur morphologische Kriterien eingeschlossen. Resultate einer Farbdoppler-Sonografie als ergänzendem Verfahren werden in diesen Klassifizierungen nicht berücksichtigt, obwohl eine erhöhte intranoduläre Vaskularisation bei follikulären Neoplasien mit einem erhöhten Malignitätsrisiko assoziiert ist. Aktuell werden die neuen Systeme evaluiert und müssen gegebenenfalls für die klinische Praxis optimiert werden. Außerdem gibt es erste Ansätze, die Dokumentation der Ultraschallergebnisse weiter zu standardisieren, um die diagnostischen Möglichkeiten der Ultraschalluntersuchung im Sinne der Verbesserung der Patientenversorgung zu optimieren.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Kommentar der Schriftleitung

Laryngo-Rhino-Otol 2019; 98: 68-69
DOI: 10.1055/a-0784-9800

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Nachruf Prof. Dr. Heinz R. Stammberger

Laryngo-Rhino-Otol 2019; 98: 76-76
DOI: 10.1055/a-0828-5454

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GgV4EA

Kehlkopf-Karzinom: Wundbettbiopsien nach TLM-Behandlung sinnvoll

Laryngo-Rhino-Otol 2019; 98: 71-72
DOI: 10.1055/a-0785-0981

Hendriksma M et al. Evaluation of surgical margin status in patients with early glottic cancer (Tis-T2) treated with transoral CO2 laser microsurgery, on local control. Eur Arch Otorhinolaryngol 2018; 275: 2333–2340 Bei Patienten mit primärem Kehlkopf-Plattenepithelkarzinom (Tis-T2) beurteilten niederländische Kopf- und Hals-Chirurgen den Effekt des Resektionsrand-Status auf die lokale Kontrollrate nach Behandlung mit transoraler CO2-Laser-Mikrochirurgie (TLM). Darüber hinaus überprüften die Bedeutung zusätzlicher Wundbettbiopsien.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2I2G2Eh

Assoziation von allergischer Rhinitis und Hypertonie untersucht

Laryngo-Rhino-Otol 2019; 98: 74-75
DOI: 10.1055/a-0651-4041

Sakallioglu O et al. Allergic rhinitis and arterial blood pressure: a population-based study. J Laryngol Otol 2018; 132: 418–422 Gibt es einen Zusammenhang von allergischer Rhinitis und arteriellem Blutdruck sowie Bluthochdruck? In einer bevölkerungsbasierten Untersuchung wollten türkische Ärzte diese Frage klären.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GiMftI

Beurteilung der Tubenfunktionsstörung mit dem ETDQ-7

Laryngo-Rhino-Otol 2019; 98: 72-74
DOI: 10.1055/a-0621-2000

Harju T et al. Eustachian Tube Dysfunction–Related Symptoms in Chronic Nasal Obstruction Caused by Inferior Turbinate Enlargement. Ann Otol Rhinol Laryngol 2017; 126: 798–803 Ärzte des Universitätskrankenhauses von Tampere, Finnland, beurteilten den Zusammenhang zwischen chronischer Nasenverstopfung durch Vergrößerung der unteren Nasenmuschel und Symptomen, die durch eine Eustachi-Tubendysfunktion bedingt sind, mit Hilfe des „Eustachian Tube Dysfunction Questionnaire" (ETDQ-7) als Instrument zur Evaluation einer Tubenfunktionsstörung.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Spiegeluntersuchung in der HNO

Laryngo-Rhino-Otol 2019; 98: 77-78
DOI: 10.1055/a-0784-9833

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

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Wenn gehörlose Kinder hörend werden – Auswirkungen der CI-Versorgung von gehörlosen Kindern gehörloser Eltern auf deren Familiensituation

Laryngo-Rhino-Otol 2019; 98: 85-90
DOI: 10.1055/a-0790-0934

1993 wurden erstmalig gehörlose Kinder von gehörlosen Eltern mit CI versorgt. Die Situation dieser Kinder und ihrer Eltern ist immer wieder Gegenstand von Forschungen des seit 2000 bestehenden Münchner Forschungsprogramms „Gehörlose Eltern und Kinder mit CI". Zu diesem gehört die Teilstudie „Familiensituation von gehörlosen Eltern mit CI-Kindern". Eines der Ergebnisse dieser Studie ist, dass die implantierten Kinder die Rolle von Codas übernehmen. Das zeigt sich insbesondere in der Übernahme von Dolmetschleistungen für die Eltern.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Faziale Hauttumore: Resektion und plastische Defektrekonstruktion – Teil 1

Laryngo-Rhino-Otol 2019; 98: 117-128
DOI: 10.1055/a-0784-9844

Die Häufigkeit von Tumoren der Gesichtshaut nimmt aufgrund der steigenden UV-Exposition und der zunehmenden Alterung der Bevölkerung zu. Gleichzeitig steigen die Ansprüche an die Funktion und Ästhetik der rekonstruktiven Chirurgie im Gesicht. Die In-sano-Resektion mit Sicherheitsabstand ist der entscheidende erste Schritt eines operativen Vorgehens. Die anschließende Rekonstruktion ist von patientenspezifischen und weiteren Faktoren abhängig.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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Retinovaskuläre Zeichen des Susac-Syndroms

Laryngo-Rhino-Otol 2019; 98: 108-113
DOI: 10.1055/a-0747-6968

Hintergrund Das Susac-Syndrom ist eine Vaskulopathie mit Manifestationen am zentralen Nervensystem, an der Retina und am Innenohr und ist gekennzeichnet durch die klinische Trias aus Enzephalopathie und/oder fokalen neurologischen Symptomen, Hörminderung und retinalen Arterienastverschlüssen. Bisher wurden nur etwa 300 Fälle in der medizinischen Literatur beschrieben. Patienten/Methoden Drei Patienten mit gesichertem Susac-Syndrom wurden retrospektiv auf das Vorhandensein krankheitstypischer retinaler Veränderungen untersucht. Ergänzend wurde der Krankheitsverlauf analysiert mit der Zielsetzung, ein besseres Krankheitsverständnis zu erreichen. Ergebnisse In allen 3 beschriebenen Fällen besteht eine okklusive retinale Mikroangiopathie mit einhergehenden Arterienastverschlüssen. In der cMRT zeigen sich bei 2 von 3 Fällen krankheitstypische, umschriebene „snowball"-artige Läsionen des Corpus callosum, die gemeinsam mit dem Netzhautbefund die diagnostische Zuordnung ermöglichten. Die klassische Trias aus Innenohrschwerhörigkeit, retinalen Arterienastverschlüssen und ZNS-Symptomatik war allerdings in keinem der Fälle bei ärztlichem Erstkontakt vollständig ausgeprägt. Schlussfolgerung Die Diagnosesicherung setzt eine enge interdisziplinäre Zusammenarbeit zwischen Neurologen, Psychiatern, HNO- und Augenärzten voraus. Die typischen okulären Zeichen einer segmentalen Mikrovaskulopathie mit Okklusion kleiner Arterien sollten auch bei isoliertem Auftreten Anlass dazu geben, das Krankheitsbild in die Differenzialdiagnose einer okklusiven retinalen Vaskulopathie mit einzubeziehen.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Mindestmengen: Die Qual der Zahl oder Mittel der Qualitätssicherung?

Laryngo-Rhino-Otol 2019; 98: 114-116
DOI: 10.1055/a-0784-9855

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

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Fragen für die Facharztprüfung

Laryngo-Rhino-Otol 2019; 98: 129-130
DOI: 10.1055/a-0784-9866

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

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Erratum: Stellenwert der Sialendoskopie an deutschen HNO-Kliniken im Jahr 2016

Laryngo-Rhino-Otol 2019; 98: E1-E1
DOI: 10.1055/a-0849-2046

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

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Fehlbildungschirurgie von Nase und Lippe

Laryngo-Rhino-Otol 2019; 98: 131-133
DOI: 10.1055/a-0784-9910

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

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Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy

As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy.

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Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy

As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy.

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Why salivary diagnostics for dental practices?

Source: www.dentistryiq.com Author: Barbara Kreuger, MA, RDH I recently had the opportunity to visit OralDNA Labs and learn more about the […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UNC4Ri

‘They needed something more after treatment’

Source: www.nursingtimes.net Author: Claire Reed Lesley Taylor wanted to examine the lack of support for patients at the end of treatment, […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TBh2F7

Why salivary diagnostics for dental practices?

Source: www.dentistryiq.com Author: Barbara Kreuger, MA, RDH I recently had the opportunity to visit OralDNA Labs and learn more about the […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UNC4Ri

‘They needed something more after treatment’

Source: www.nursingtimes.net Author: Claire Reed Lesley Taylor wanted to examine the lack of support for patients at the end of treatment, […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TBh2F7

Prescription of Potentially Inappropriate Medications in Geriatric Patients: Data from a Single Dental Institution

The Beers Criteria and the Screening Tool of Older Persons' Potentially Inappropriate Prescriptions(STOPP) are consensus-driven lists of potentially inappropriate medications(PIMs) in geriatric patients. The Primary objective was to determine the frequency of PIMs prescribed to geriatrics at Tufts University School of Dental Medicine(TUSDM). The secondary aim was to determine the American Society of Anesthesiologists (ASA) status of these patients and suggest that Beers/STOPP guidelines should be implied with consideration to the patient's ASA status.

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A bibliometric analysis of the most cited articles about squamous cell carcinoma of the mouth, lips and oropharynx

to identify the top cited articles about squamous cell carcinoma of the mouth, lips, and oropharynx.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ShHcQR

Prescription of Potentially Inappropriate Medications in Geriatric Patients: Data from a Single Dental Institution

The Beers Criteria and the Screening Tool of Older Persons' Potentially Inappropriate Prescriptions(STOPP) are consensus-driven lists of potentially inappropriate medications(PIMs) in geriatric patients. The Primary objective was to determine the frequency of PIMs prescribed to geriatrics at Tufts University School of Dental Medicine(TUSDM). The secondary aim was to determine the American Society of Anesthesiologists (ASA) status of these patients and suggest that Beers/STOPP guidelines should be implied with consideration to the patient's ASA status.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DhpvX6

A bibliometric analysis of the most cited articles about squamous cell carcinoma of the mouth, lips and oropharynx

to identify the top cited articles about squamous cell carcinoma of the mouth, lips, and oropharynx.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ShHcQR

Navigation-guided fibula free flap for mandibular reconstruction – a proof of concept study

To analyze a novel technique of supporting fibula free flap harvest and fabrication with intraoperative navigation technology.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2USl903

Multiple lymphatic-venous anastomoses in reducing the risk of lymphedema in melanoma patients undergoing complete lymph node dissection. A retrospective case-control study

Sentinel lymph node biopsy (SLNB) is an indispensable surgical procedure in staging and management of intermediate-thick melanomas. Although recent studies have demonstrated that complete lymph node dissection (CLND) does not improve 3-years specific survival, its utility in increasing the disease-free period and the control of local disease remains confirmed. The most frequent complication related to CLND is lymphedema, which may affect up to 20% of patients undergoing CLND. The preventive use of lymphatic-venous micro-anastomoses could avoid this complication.

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Navigation-guided fibula free flap for mandibular reconstruction – a proof of concept study

To analyze a novel technique of supporting fibula free flap harvest and fabrication with intraoperative navigation technology.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2USl903

Multiple lymphatic-venous anastomoses in reducing the risk of lymphedema in melanoma patients undergoing complete lymph node dissection. A retrospective case-control study

Sentinel lymph node biopsy (SLNB) is an indispensable surgical procedure in staging and management of intermediate-thick melanomas. Although recent studies have demonstrated that complete lymph node dissection (CLND) does not improve 3-years specific survival, its utility in increasing the disease-free period and the control of local disease remains confirmed. The most frequent complication related to CLND is lymphedema, which may affect up to 20% of patients undergoing CLND. The preventive use of lymphatic-venous micro-anastomoses could avoid this complication.

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Safety of tooth extraction in patients receiving direct oral anticoagulant treatment versus warfarin: a prospective observation study

The aim of this study was to compare the safety of tooth extraction in patients receiving direct oral anticoagulants (DOACs) or warfarin without cessation of their antithrombotic treatment. This prospective observational study included 367 patients undergoing tooth extraction (119 receiving DOACs and 248 receiving warfarin). All extractions in DOAC patients were performed 6–7h after taking DOACs in consideration of the half-life in blood under continued antithrombotic treatment. To examine the potential postoperative bleeding risk related to the time of extraction and the drug concentration of blood, activated partial thromboplastin time (APTT) in dabigatran and prothrombin time (PT) in rivaroxaban were measured three times after administration.

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Safety of tooth extraction in patients receiving direct oral anticoagulant treatment versus warfarin: a prospective observation study

The aim of this study was to compare the safety of tooth extraction in patients receiving direct oral anticoagulants (DOACs) or warfarin without cessation of their antithrombotic treatment. This prospective observational study included 367 patients undergoing tooth extraction (119 receiving DOACs and 248 receiving warfarin). All extractions in DOAC patients were performed 6–7h after taking DOACs in consideration of the half-life in blood under continued antithrombotic treatment. To examine the potential postoperative bleeding risk related to the time of extraction and the drug concentration of blood, activated partial thromboplastin time (APTT) in dabigatran and prothrombin time (PT) in rivaroxaban were measured three times after administration.

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Guaiacol/β-cyclodextrin for rapid healing of dry socket: antibacterial activity, cytotoxicity, and bone repair—an animal study

Abstract

Purpose

Dry socket (DS) is one the most common and symptomatic post-extraction complications; however, no consensus on its treatment has been reached. This study aimed to develop a novel dressing material for DS containing the phenolic agent guaiacol and evaluate its biological properties.

Methods

An inclusion complex of guaiacol and β-cyclodextrin (Gu/βcd) was prepared by freeze-drying. Its antibacterial activity over six oral bacteria was analyzed using the microdilution method, and its cytotoxicity in osteoblasts was assessed with the MTT assay. The alveolar healing process induced by Gu/βcd was evaluated histologically after the treatment of DS in rats.

Results

βcd complexation potentiated Gu's antibacterial effect and reduced its cytotoxicity in osteoblasts. Bone trabeculae were formed in the alveolar apices of rats treated with Gu/βcd by day 7. On day 14, woven bone occupied the apical and middle thirds of the sockets; on day 21, the entire alveolus was filled by newly formed bone, which was in a more advanced stage of repair than the positive control (Alvogyl™).

Conclusion

The improvement in Gu's biological properties in vitro and the rapid alveolar repair in comparison with Alvogyl™ in vivo demonstrated the benefits of the Gu/βcd complex as a future alternative for the treatment of DS.

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Guaiacol/β-cyclodextrin for rapid healing of dry socket: antibacterial activity, cytotoxicity, and bone repair—an animal study

Abstract

Purpose

Dry socket (DS) is one the most common and symptomatic post-extraction complications; however, no consensus on its treatment has been reached. This study aimed to develop a novel dressing material for DS containing the phenolic agent guaiacol and evaluate its biological properties.

Methods

An inclusion complex of guaiacol and β-cyclodextrin (Gu/βcd) was prepared by freeze-drying. Its antibacterial activity over six oral bacteria was analyzed using the microdilution method, and its cytotoxicity in osteoblasts was assessed with the MTT assay. The alveolar healing process induced by Gu/βcd was evaluated histologically after the treatment of DS in rats.

Results

βcd complexation potentiated Gu's antibacterial effect and reduced its cytotoxicity in osteoblasts. Bone trabeculae were formed in the alveolar apices of rats treated with Gu/βcd by day 7. On day 14, woven bone occupied the apical and middle thirds of the sockets; on day 21, the entire alveolus was filled by newly formed bone, which was in a more advanced stage of repair than the positive control (Alvogyl™).

Conclusion

The improvement in Gu's biological properties in vitro and the rapid alveolar repair in comparison with Alvogyl™ in vivo demonstrated the benefits of the Gu/βcd complex as a future alternative for the treatment of DS.

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Sleep Measurement in Toddlers From Low-income Families

ABSTRACT: Objectives: (1) To examine toddler sleep in a low-income sample by comparing sleep diaries and actigraphy and (2) to assess whether toddlers are meeting the National Sleep Foundation recommendations (11–14 hours of sleep/24 hours and bedtime before 9 PM). Methods: A convenience sample of mother-toddler dyads was recruited from 2 health care sites serving low-income communities. An actigraph was placed on the toddler's ankle and was worn for 3 days and nights. Mothers concurrently completed a sleep diary. Bedtime, nighttime sleep duration, nap duration, and 24-hour sleep duration were collected by both measures. Actigraphy data were analyzed using a combination of manufacturer's scoring algorithm and manual editing. Descriptive statistics and paired samples t-tests were conducted to examine the differences between sleep estimates by a sleep diary and actigraphy. Results: Twenty toddlers (aged 13–42 months) were included in the analyses. Based on actigraphy, 1 toddler went to bed by 9 PM on all 3 nights. Six toddlers achieved 11 to 14 hours of sleep measured in a 24-hour period for 1 of the 3 days, but when sleep was averaged across the study, none achieved this goal. Compared with actigraphy, sleep diaries underestimated bedtime by 1 hour, overestimated nighttime sleep duration by 2.5 hours, and overestimated 24-hour sleep duration by 2.3 hours, on average for all 3 nights. Conclusion: Mothers reported significantly earlier bedtimes and longer sleep durations for their toddlers compared with actigraphy, suggesting that objective measures differ from sleep diaries in assessing sleep in toddlers from low-income families. Findings should not be generalized to populations of low-income families without replication. Address for reprints: Lauren B. Covington, PhD, MS, RN, University of Delaware, School of Nursing, 100 Discovery Boulevard, 5th floor, Newark, DE 19713; e-mail: lcovingt@udel.edu. Supported in part by funding through the Children's HealthWatch donors, which are listed in http://bit.ly/1eRrd00. L.B. Covington was supported through a grant from Sigma, Global Nursing Excellence, Pi Chapter. Disclosure: The authors declare no conflicts of interest. Received September 23, 2018 Accepted December 26, 2018 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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Abstracts of Platform Sessions and Posters Accepted for Presentation at the 2018 Annual Meeting of the Society for Developmental and Behavioral Pediatrics

No abstract available

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The Combined Impact of Sleep and Diet on Adiposity in Infants, Toddlers, and Young Children: A Systematic Review

ABSTRACT: Objective: Short sleep duration and poor dietary habits may contribute to increased adiposity; however, the impact of the interaction between these variables on adiposity is less understood. To evaluate research investigating the combined effects of sleep and diet on adiposity in infants, toddlers, and young children. Methods: Systematic searches of electronic databases (PubMed, CINAHL, and Web of Science) from inception through April 2017 were conducted. All studies published in English that had at least 1 sleep (e.g., sleep duration and night awakenings), diet (e.g., 24-hour diet recall and breastfeeding duration), and adiposity (e.g., body mass index z-score and weight-for-length) measure were eligible for inclusion. Abstract and full-text article reviews were conducted by 2 independent reviewers. Data were extracted into a standardized spreadsheet. Results: Of the 17 full-text articles reviewed, 14 studies were included. Mediation (n = 2) and moderation (n = 2) were seldom used. Investigation of the combined effects of sleep and diet on adiposity demonstrated a substantial lack of evidence. Synthesis of articles suggests that the relationship between sleep and diet may be interactive and their effects additive in their impact when targeted simultaneously within interventions. Conclusion: Without consideration of interaction effects among variables of interest, a substantial gap in the literature persists. Both diet and sleep need to be assessed simultaneously and repetitively in future longitudinal research. Address for reprints: Megan E. Petrov, PhD, College of Nursing and Health Innovation, Arizona State University, HealthSouth Bldg, Rm 358J, 500 N. 3rd St., Phoenix, AZ 85004; e-mail: megan.petrov@asu.edu. Disclosure: The authors declare no conflict of interest. Systematic Review Registration: PROSPERO 2017: CRD42017065870. Received November 03, 2017 Accepted October 16, 2018 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2I2WAvP

Sleep Measurement in Toddlers From Low-income Families

ABSTRACT: Objectives: (1) To examine toddler sleep in a low-income sample by comparing sleep diaries and actigraphy and (2) to assess whether toddlers are meeting the National Sleep Foundation recommendations (11–14 hours of sleep/24 hours and bedtime before 9 PM). Methods: A convenience sample of mother-toddler dyads was recruited from 2 health care sites serving low-income communities. An actigraph was placed on the toddler's ankle and was worn for 3 days and nights. Mothers concurrently completed a sleep diary. Bedtime, nighttime sleep duration, nap duration, and 24-hour sleep duration were collected by both measures. Actigraphy data were analyzed using a combination of manufacturer's scoring algorithm and manual editing. Descriptive statistics and paired samples t-tests were conducted to examine the differences between sleep estimates by a sleep diary and actigraphy. Results: Twenty toddlers (aged 13–42 months) were included in the analyses. Based on actigraphy, 1 toddler went to bed by 9 PM on all 3 nights. Six toddlers achieved 11 to 14 hours of sleep measured in a 24-hour period for 1 of the 3 days, but when sleep was averaged across the study, none achieved this goal. Compared with actigraphy, sleep diaries underestimated bedtime by 1 hour, overestimated nighttime sleep duration by 2.5 hours, and overestimated 24-hour sleep duration by 2.3 hours, on average for all 3 nights. Conclusion: Mothers reported significantly earlier bedtimes and longer sleep durations for their toddlers compared with actigraphy, suggesting that objective measures differ from sleep diaries in assessing sleep in toddlers from low-income families. Findings should not be generalized to populations of low-income families without replication. Address for reprints: Lauren B. Covington, PhD, MS, RN, University of Delaware, School of Nursing, 100 Discovery Boulevard, 5th floor, Newark, DE 19713; e-mail: lcovingt@udel.edu. Supported in part by funding through the Children's HealthWatch donors, which are listed in http://bit.ly/1eRrd00. L.B. Covington was supported through a grant from Sigma, Global Nursing Excellence, Pi Chapter. Disclosure: The authors declare no conflicts of interest. Received September 23, 2018 Accepted December 26, 2018 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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Race, Ethnicity, Socioeconomic Factors, and Attention-Deficit Hyperactivity Disorder

No abstract available

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GeNBWJ

Abstracts of Platform Sessions and Posters Accepted for Presentation at the 2018 Annual Meeting of the Society for Developmental and Behavioral Pediatrics

No abstract available

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GgSbDB

Journal Article Reviews

No abstract available

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2I0pcFP

The Combined Impact of Sleep and Diet on Adiposity in Infants, Toddlers, and Young Children: A Systematic Review

ABSTRACT: Objective: Short sleep duration and poor dietary habits may contribute to increased adiposity; however, the impact of the interaction between these variables on adiposity is less understood. To evaluate research investigating the combined effects of sleep and diet on adiposity in infants, toddlers, and young children. Methods: Systematic searches of electronic databases (PubMed, CINAHL, and Web of Science) from inception through April 2017 were conducted. All studies published in English that had at least 1 sleep (e.g., sleep duration and night awakenings), diet (e.g., 24-hour diet recall and breastfeeding duration), and adiposity (e.g., body mass index z-score and weight-for-length) measure were eligible for inclusion. Abstract and full-text article reviews were conducted by 2 independent reviewers. Data were extracted into a standardized spreadsheet. Results: Of the 17 full-text articles reviewed, 14 studies were included. Mediation (n = 2) and moderation (n = 2) were seldom used. Investigation of the combined effects of sleep and diet on adiposity demonstrated a substantial lack of evidence. Synthesis of articles suggests that the relationship between sleep and diet may be interactive and their effects additive in their impact when targeted simultaneously within interventions. Conclusion: Without consideration of interaction effects among variables of interest, a substantial gap in the literature persists. Both diet and sleep need to be assessed simultaneously and repetitively in future longitudinal research. Address for reprints: Megan E. Petrov, PhD, College of Nursing and Health Innovation, Arizona State University, HealthSouth Bldg, Rm 358J, 500 N. 3rd St., Phoenix, AZ 85004; e-mail: megan.petrov@asu.edu. Disclosure: The authors declare no conflict of interest. Systematic Review Registration: PROSPERO 2017: CRD42017065870. Received November 03, 2017 Accepted October 16, 2018 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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Race, Ethnicity, Socioeconomic Factors, and Attention-Deficit Hyperactivity Disorder

No abstract available

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GeNBWJ

Journal Article Reviews

No abstract available

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Reply

We have with great interest read the comment from Liccardi et al1 on our article recently published in the Journal.2 We share the opinion that the male dog allergen Can f 5 is an intriguing molecule that deserves further investigation. Sensitization to Can f 5 has in several studies been shown to play a role in respiratory allergy and it is known that monosensitization to Can f 5 occurs in a considerable proportion of dog dander–sensitized individuals. In the current study of dog dander–sensitized children we found that monosensitization to Can f 5 was associated with a negative nasal provocation test (NPT) result with dog dander extract (odds ratio, 5.78; 95% CI, 1.01-33.0).

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Can f 5 as a suitable marker of dog allergy: Assess male dog exposure before banning it

We read with interest the excellent article by Käck et al1 focusing on the role of different dog allergens in inducing nasal symptoms as assessed by nasal provocation tests (NPTs). It is well known that a significant percentage of individuals sensitized to dog allergens by skin prick tests do not develop overt respiratory symptoms (asthma and/or rhinitis) after direct dog exposure. For this reason, NPTs can be regarded as the "criterion standard" to clarify whether a sensitization to dog allergens can be regarded clinically relevant.

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In-Vitro Setup to Test Hydroxy-Propyl-Methyl-Cellulose as Allergen Barrier over a Span of 360 Minutes

Powder hydroxy-propyl-methyl-cellulose (pHPMC), insufflated in the nose, swells and makes a gel barrier against offending allergens. Most clinical studies demonstrating efficacy of pHPMC have been done in patients sensitized to grass and birch pollens.We set up an in vitro study to document the reduction by pHPMC of the diffusion in agar of 3 other common allergens.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TEi0AL

Reply

We have with great interest read the comment from Liccardi et al1 on our article recently published in the Journal.2 We share the opinion that the male dog allergen Can f 5 is an intriguing molecule that deserves further investigation. Sensitization to Can f 5 has in several studies been shown to play a role in respiratory allergy and it is known that monosensitization to Can f 5 occurs in a considerable proportion of dog dander–sensitized individuals. In the current study of dog dander–sensitized children we found that monosensitization to Can f 5 was associated with a negative nasal provocation test (NPT) result with dog dander extract (odds ratio, 5.78; 95% CI, 1.01-33.0).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TKMHo1

Can f 5 as a suitable marker of dog allergy: Assess male dog exposure before banning it

We read with interest the excellent article by Käck et al1 focusing on the role of different dog allergens in inducing nasal symptoms as assessed by nasal provocation tests (NPTs). It is well known that a significant percentage of individuals sensitized to dog allergens by skin prick tests do not develop overt respiratory symptoms (asthma and/or rhinitis) after direct dog exposure. For this reason, NPTs can be regarded as the "criterion standard" to clarify whether a sensitization to dog allergens can be regarded clinically relevant.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BvfXrz

In-Vitro Setup to Test Hydroxy-Propyl-Methyl-Cellulose as Allergen Barrier over a Span of 360 Minutes

Powder hydroxy-propyl-methyl-cellulose (pHPMC), insufflated in the nose, swells and makes a gel barrier against offending allergens. Most clinical studies demonstrating efficacy of pHPMC have been done in patients sensitized to grass and birch pollens.We set up an in vitro study to document the reduction by pHPMC of the diffusion in agar of 3 other common allergens.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TEi0AL

Why salivary diagnostics for dental practices?

Source: www.dentistryiq.com Author: Barbara Kreuger, MA, RDH I recently had the opportunity to visit OralDNA Labs and learn more about the […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UNC4Ri

Chronic Rhinosinusitis May Up Risk for Anxiety, Depression Chronic Rhinosinusitis May Up Risk for Anxiety, Depression

Chronic rhinosinusitis is associated with increased risk for anxiety and depression. An expert says possible causal links are unclear, but he supports mental health screening for these patients.Medscape Medical News (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tadRsA

Why salivary diagnostics for dental practices?

Source: www.dentistryiq.com Author: Barbara Kreuger, MA, RDH I recently had the opportunity to visit OralDNA Labs and learn more about the […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UNC4Ri

Chronic Rhinosinusitis May Up Risk for Anxiety, Depression Chronic Rhinosinusitis May Up Risk for Anxiety, Depression

Chronic rhinosinusitis is associated with increased risk for anxiety and depression. An expert says possible causal links are unclear, but he supports mental health screening for these patients.Medscape Medical News (Source: Medscape Allergy Headlines)

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‘They needed something more after treatment’

Source: www.nursingtimes.net Author: Claire Reed Lesley Taylor wanted to examine the lack of support for patients at the end of treatment, […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TBh2F7

‘They needed something more after treatment’

Source: www.nursingtimes.net Author: Claire Reed Lesley Taylor wanted to examine the lack of support for patients at the end of treatment, […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TBh2F7

Early Introduction of Egg and Development of Egg Allergy

Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Early Introduction of Egg and Development of Egg Allergy

Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Towards Health Equity: Deaf Adults & #8217; Engagement in Social e-Health Activities and e-Communication with Health Care Providers

(Source: Journal of Health Communication)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UQLFaa

Towards Health Equity: Deaf Adults & #8217; Engagement in Social e-Health Activities and e-Communication with Health Care Providers

(Source: Journal of Health Communication)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UQLFaa

Comparative analysis of the intervertebral disc signal and annulus changes between immediate and 1-year postoperative MRI after transforaminal endoscopic lumbar discectomy and annuloplasty

Abstract

Purpose

Postoperative magnetic resonance imaging (MRI) after microdiscectomy for lumbar disc herniation frequently shows spinal canal compression by the remaining annulus, which gradually decreases over time. Transforaminal endoscopic lumbar discectomy (TELD) can remove the herniation with minimal trauma to surrounding soft tissue. We aim to identify this remodeling of annulus fibrosus and the change of disc signal after TELD.

Methods

We reviewed patients who underwent TELD. Clinical data obtained were Oswestry disability index (ODI) and visual analog scale (VAS) for back and leg pain. Residual mass signal and disc protrusion size were measured in postoperative MRI.

Results

Thirty-one patients were reviewed. The mean age was 38.3 ± 14.4 years (range 18 to 76 years). ODI was 18.2% at the first follow-up and 12.7% at the last follow-up (p = 0.009). VAS for back and leg pain were 2.0 and 1.0 without significant change during follow-up. Disc protrusion size was reduced by 67.7% at the 1-year follow-up (p < 0.001). The residual mass signals at postoperative day 1 were high in 12 cases, intermediate in 18 cases, and low in1 case. The signal intensity was correlated with the percentage of disc protrusion reduction (p = 0.048). The percentage of disc protrusion reduction correlated with the last follow-up ODI (p = 0.018).

Conclusion

One year after TELD, annulus remodeling was observed with an average of 67.7% of size reduction. The high signal intensity of residual mass at day 1 correlated with disc protrusion reduction at follow-up MRI. The percentage of disc protrusion reduction associated with the ODI at the final follow-up.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HZws4X

Comparative analysis of the intervertebral disc signal and annulus changes between immediate and 1-year postoperative MRI after transforaminal endoscopic lumbar discectomy and annuloplasty

Abstract

Purpose

Postoperative magnetic resonance imaging (MRI) after microdiscectomy for lumbar disc herniation frequently shows spinal canal compression by the remaining annulus, which gradually decreases over time. Transforaminal endoscopic lumbar discectomy (TELD) can remove the herniation with minimal trauma to surrounding soft tissue. We aim to identify this remodeling of annulus fibrosus and the change of disc signal after TELD.

Methods

We reviewed patients who underwent TELD. Clinical data obtained were Oswestry disability index (ODI) and visual analog scale (VAS) for back and leg pain. Residual mass signal and disc protrusion size were measured in postoperative MRI.

Results

Thirty-one patients were reviewed. The mean age was 38.3 ± 14.4 years (range 18 to 76 years). ODI was 18.2% at the first follow-up and 12.7% at the last follow-up (p = 0.009). VAS for back and leg pain were 2.0 and 1.0 without significant change during follow-up. Disc protrusion size was reduced by 67.7% at the 1-year follow-up (p < 0.001). The residual mass signals at postoperative day 1 were high in 12 cases, intermediate in 18 cases, and low in1 case. The signal intensity was correlated with the percentage of disc protrusion reduction (p = 0.048). The percentage of disc protrusion reduction correlated with the last follow-up ODI (p = 0.018).

Conclusion

One year after TELD, annulus remodeling was observed with an average of 67.7% of size reduction. The high signal intensity of residual mass at day 1 correlated with disc protrusion reduction at follow-up MRI. The percentage of disc protrusion reduction associated with the ODI at the final follow-up.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HZws4X