Evaluation of biodegradable gel containing flax seed extract (Linum usitatissimum) as a targeted drug delivery for management of chronic periodontitis

Publication date: Available online 15 December 2018

Source: Journal of Herbal Medicine

Author(s): Pappu R, Varghese J, Koteshwara KB, Dr.Kamath V, Lobo R, K. Nimmy

Abstract

Treatment of periodontitis has been one of the most challenging aspects of periodontal therapy. The role of host immune inflammatory response in periodontal disease forms the basis of modernistic therapeutic approaches. The present study evaluates the efficacy of an indigenously formulated flax seed extract in the form of biodegradable gel, as an adjunct in the treatment of chronic periodontitis. Sixty patients diagnosed with localized periodontal disease having pocket probing depth ≥ 5 mm were selected. All the patients were treated with professional oral prophylaxis and root instrumentation as part of the standard periodontal care protocol. The participants were divided into 3 groups with 20 subjects in each group. One group received the formulated flax seed extract gel and second group received flurbiprofen gel. The third and/or control group did not receive any adjunct therapy. The following measurements were recorded at baseline, first and third month, i.e. Gingival crevicular fluid (GCF) and saliva samples for estimation of drug release followed by record of clinical parameters i.e. plaque index, gingival index, pocket probing depth and clinical attachment levels. The results of the study demonstrated that the flax seed extract gel could be equally associated to the effectiveness of flurbiprofen gel, at the end of 90 days (p = 0.001). Hence, this randomized clinical trial sets a route for incorporating herbal constituents as targeted drug therapeutic agents for the management of chronic periodontitis. Also, the use of these phytotherapeutic agents can be further incited considering its safety, low risk and economical options.

Graphical abstract

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