AbstractThe ongoing revolution in cancer immunotherapy stems from the knowledge that distinct immune-checkpoints regulate the physiological crosstalk between and among immune cells by delivering inhibitory or activating signals. These notions, and the availability of mAb directed to diverse immune-checkpoint molecules, have led to a significant clinical improvement in cancer treatment. In this scenario, further achievements are undoubtedly to be expected from the contribution of novel, proof-of-principle clinical trials designed to explore the therapeutic efficacy of new immunotherapy-based combinations and treatment sequences. Along these lines, the clinical translation of pre-clinical evidence generated by non-profit research entities is likely to provide a significant contribution to ga...
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Δευτέρα 17 Δεκεμβρίου 2018
The Italian Network for Tumor Bio-Immunotherapy (NIBIT) Foundation: ongoing and prospective activities in immuno-oncology
Addressing current challenges and future directions in immuno-oncology: expert perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy
AbstractA collaborative think tank involving panellists from immuno-oncology networks, clinical/translational investigators and the pharmaceutical industry was held in Siena, Italy, in October 2017 to discuss the evolving immune-oncology landscape, identify selected key challenges, and provide a perspective on the next steps required in the translation of current research and knowledge to clinical reality. While there is a trend of combining new agents (e.g., co-stimulator agonists) with a PD-1/PD-L1 treatment backbone, use of alternative combination therapy approaches should also be considered. While the rapid evolution in systems biology provides a deeper understanding of tumor and tumor microenvironment heterogeneity, there remains the need to identify and define genuinely predictive bi...
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The Italian Network for Tumor Bio-Immunotherapy (NIBIT) Foundation: ongoing and prospective activities in immuno-oncology
AbstractThe ongoing revolution in cancer immunotherapy stems from the knowledge that distinct immune-checkpoints regulate the physiological crosstalk between and among immune cells by delivering inhibitory or activating signals. These notions, and the availability of mAb directed to diverse immune-checkpoint molecules, have led to a significant clinical improvement in cancer treatment. In this scenario, further achievements are undoubtedly to be expected from the contribution of novel, proof-of-principle clinical trials designed to explore the therapeutic efficacy of new immunotherapy-based combinations and treatment sequences. Along these lines, the clinical translation of pre-clinical evidence generated by non-profit research entities is likely to provide a significant contribution to ga...
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Oncology Conference: Advances in Cancer Immunotherapy™ (ACI) – Sacramento, CA - Sacramento January 10, 2019 - MD Linx
Specifically designed by the Society for Immunotherapy of Cancer (SITC) for clinical oncologists, pharmacists, and the entire cancer care team, the Advances in ...
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FDA Approval in NSCLC, Priority Review in SCLC, 2018 SABCS Highlights, and More - OncLive
Gina Columbus reports on an FDA approval in non-small cell lung cancer, a priority review in small cell lung cancer, disappointing findings in both head and ...
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Cx±platinum–fluorouracil-based chemotherapy in head and neck CA | European Archives of Oto-Rhino-Laryngology - MD Linx
Internal Medicine Article: Benefit of cetuximab addition to a platinum–fluorouracil-based chemotherapy according to KRAS-LCS6 variant in an unselected ...
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Oncology Conference: Advances in Cancer Immunotherapy™ (ACI) – Sacramento, CA - Sacramento January 10, 2019 - MD Linx
Specifically designed by the Society for Immunotherapy of Cancer (SITC) for clinical oncologists, pharmacists, and the entire cancer care team, the Advances in ...
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FDA Approval in NSCLC, Priority Review in SCLC, 2018 SABCS Highlights, and More - OncLive
Gina Columbus reports on an FDA approval in non-small cell lung cancer, a priority review in small cell lung cancer, disappointing findings in both head and ...
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Cx±platinum–fluorouracil-based chemotherapy in head and neck CA | European Archives of Oto-Rhino-Laryngology - MD Linx
Internal Medicine Article: Benefit of cetuximab addition to a platinum–fluorouracil-based chemotherapy according to KRAS-LCS6 variant in an unselected ...
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Clinical Performance Measures that Matter —Are You Ready?
Conclusion The future will belong to those who can prove value. The use of a clinical performance dashboard and comparisons to national data will help to ensure that when the payers come knocking on our doors looking for "proof" that what we do enhances patient care and improves patient outcome, we'll have an answer! This is the first in a yearlong series of articles developed by the Academy of International Mobile Healthcare Integration (AIMHI).The AIMHI article series is developed in partnership with JEMS to help educate EMS agencies on the hallmarks and attributes of high-performance/high-value EMS system design and operations. To learn more about AIMHI visit www.aimhi.mobi. References 1. Lagasse J. (Oct. 24, 2018.) Healthcare payments tied to value-based care...
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Clinical Performance Measures that Matter —Are You Ready?
Conclusion The future will belong to those who can prove value. The use of a clinical performance dashboard and comparisons to national data will help to ensure that when the payers come knocking on our doors looking for "proof" that what we do enhances patient care and improves patient outcome, we'll have an answer! This is the first in a yearlong series of articles developed by the Academy of International Mobile Healthcare Integration (AIMHI).The AIMHI article series is developed in partnership with JEMS to help educate EMS agencies on the hallmarks and attributes of high-performance/high-value EMS system design and operations. To learn more about AIMHI visit www.aimhi.mobi. References 1. Lagasse J. (Oct. 24, 2018.) Healthcare payments tied to value-based care...
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Former Norwich resident awarded additional $44 million in damages and interest from tobacco company - theday.com
U.S. District Judge Stefan R. Underhill has added $44 million in damages and interest to the nearly $8 million a jury awarded to former Norwich resident Barbara ...
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Iodine Status of Pregnant Women and Women of Reproductive Age in the United States
Thyroid, Ahead of Print.
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Former Norwich resident awarded additional $44 million in damages and interest from tobacco company - theday.com
U.S. District Judge Stefan R. Underhill has added $44 million in damages and interest to the nearly $8 million a jury awarded to former Norwich resident Barbara ...
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Prescribing Therapy for Hypothyroidism: Influence of Physician Characteristics
Thyroid, Ahead of Print.
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Iodine Status of Pregnant Women and Women of Reproductive Age in the United States
Thyroid, Ahead of Print.
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A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy
Thyroid, Ahead of Print.
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Hypomorphic Mutations in the BCR Signalosome Lead to Selective Immunoglobulin M Deficiency and Impaired B-cell Homeostasis
Christoph B. Geier, Kai M. T. Sauerwein, Alexander Leiss-Piller, Isabella Zmek, Michael B. Fischer, Martha M. Eibl, Hermann M. Wolf (Source: Frontiers in Immunology)
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Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease
Rachel A. Brown, Maggie Henderlight, Thuy Do, Shima Yasin, Alexei A. Grom, Monica DeLay, Sherry Thornton, Grant S. Schulert (Source: Frontiers in Immunology)
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Mechanism and Prevention of Titanium Particle-Induced Inflammation and Osteolysis
Michal Eger, Sahar Hiram-Bab, Tamar Liron, Nir Sterer, Yaron Carmi, David Kohavi, Yankel Gabet (Source: Frontiers in Immunology)
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Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever
Sandra Jeremias Catarino, Fabiana Antunes Andrade, Angelica Beate Winter Boldt, Luiza Guilherme, Iara Jose Messias-Reason (Source: Frontiers in Immunology)
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HRV16 Impairs Macrophages Cytokine Response to a Secondary Bacterial Trigger
Jamil Jubrail, Kshanti Africano-Gomez, Floriane Herit, Engin Baturcam, Gaell Mayer, Danen Mootoosamy Cunoosamy, Nisha Kurian, Florence Niedergang (Source: Frontiers in Immunology)
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Mesenteric CD103+DCs Initiate Switched Coxsackievirus B3 VP1-Specific IgA Response to Intranasal Chitosan-DNA Vaccine Through Secreting BAFF/IL-6 and Promoting Th17/Tfh Differentiation
Haoxin Zhao, Jie Yang, Qian Qian, Manli Wu, Min Li, Wei Xu (Source: Frontiers in Immunology)
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HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways
Md Masud Alam, De Yang, Anna Trivett, Thomas J. Meyer, Joost J. Oppenheim (Source: Frontiers in Immunology)
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Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling Pathway
Zhixin Xue, Chaojie Cui, Zhuojun Liao, Shiwei Xia, Pingjing Zhang, Jialin Qin, Qiang Guo, Sheng Chen, Qiong Fu, Zhihua Yin, Zhizhong Ye, Yuanjia Tang, Nan Shen (Source: Frontiers in Immunology)
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Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1 α Promotes Viral Proliferation
Peidian Shi, Yanxin Su, Ruiqiao Li, Lei Zhang, Chen Chen, Lilin Zhang, Kay Faaberg, Jinhai Huang (Source: Frontiers in Immunology)
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Oral Passive Immunization With Plasma-Derived Polyreactive Secretory-Like IgA/M Partially Protects Mice Against Experimental Salmonellosis
Blaise Corth ésy, Justine Monnerat, Marius Lötscher, Cédric Vonarburg, Alexander Schaub, Gilles Bioley (Source: Frontiers in Immunology)
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Sex Bias in Asthma Prevalence and Pathogenesis
Ruchi Shah, Dawn C. Newcomb (Source: Frontiers in Immunology)
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Shrimp miR-1000 Functions in Antiviral Immunity by Simultaneously Triggering the Degradation of Two Viral mRNAs
Yi Gong, Chenyu Ju, Xiaobo Zhang (Source: Frontiers in Immunology)
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CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II
Peter van Balen, Cornelis A. M. van Bergen, Simone A. P. van Luxemburg-Heijs, Wendy de Klerk, Esther H. M. van Egmond, Sabrina A. J. Veld, Constantijn J. M. Halkes, Jaap-Jan Zwaginga, Marieke Griffioen, Inge Jedema, J. H. Frederik Falkenburg (Source: Frontiers in Immunology)
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Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF- κB
Sura Al Zoubi, Jianmin Chen, Catherine Murphy, Lukas Martin, Fausto Chiazza, Debora Collotta, Muhammad M. Yaqoob, Massimo Collino, Christoph Thiemermann (Source: Frontiers in Immunology)
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Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis
Heather L. Caslin, Marcela T. Taruselli, Tamara Haque, Neha Pondicherry, Elizabeth A. Baldwin, Brian O. Barnstein, John J. Ryan (Source: Frontiers in Immunology)
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Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease
Rachel A. Brown, Maggie Henderlight, Thuy Do, Shima Yasin, Alexei A. Grom, Monica DeLay, Sherry Thornton, Grant S. Schulert (Source: Frontiers in Immunology)
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Mechanism and Prevention of Titanium Particle-Induced Inflammation and Osteolysis
Michal Eger, Sahar Hiram-Bab, Tamar Liron, Nir Sterer, Yaron Carmi, David Kohavi, Yankel Gabet (Source: Frontiers in Immunology)
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Interleukin-4 Receptor Alpha Expressing B Cells Are Essential to Down-Modulate Host Granulomatous Inflammation During Schistosomasis
Hlumani Ndlovu, Justin Komguep Nono, Nada Abdel Aziz, Natalie Eva Nieuwenhuizen, Frank Brombacher (Source: Frontiers in Immunology)
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Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever
Sandra Jeremias Catarino, Fabiana Antunes Andrade, Angelica Beate Winter Boldt, Luiza Guilherme, Iara Jose Messias-Reason (Source: Frontiers in Immunology)
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EF-Tu From Non-typeable Haemophilus influenzae Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies
Oskar Thofte, Yu-Ching Su, Marta Brant, Nils Littorin, Benjamin Luke Duell, Vera Alvarado, Farshid Jalalvand, Kristian Riesbeck (Source: Frontiers in Immunology)
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HRV16 Impairs Macrophages Cytokine Response to a Secondary Bacterial Trigger
Jamil Jubrail, Kshanti Africano-Gomez, Floriane Herit, Engin Baturcam, Gaell Mayer, Danen Mootoosamy Cunoosamy, Nisha Kurian, Florence Niedergang (Source: Frontiers in Immunology)
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Mesenteric CD103+DCs Initiate Switched Coxsackievirus B3 VP1-Specific IgA Response to Intranasal Chitosan-DNA Vaccine Through Secreting BAFF/IL-6 and Promoting Th17/Tfh Differentiation
Haoxin Zhao, Jie Yang, Qian Qian, Manli Wu, Min Li, Wei Xu (Source: Frontiers in Immunology)
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HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways
Md Masud Alam, De Yang, Anna Trivett, Thomas J. Meyer, Joost J. Oppenheim (Source: Frontiers in Immunology)
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Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling Pathway
Zhixin Xue, Chaojie Cui, Zhuojun Liao, Shiwei Xia, Pingjing Zhang, Jialin Qin, Qiang Guo, Sheng Chen, Qiong Fu, Zhihua Yin, Zhizhong Ye, Yuanjia Tang, Nan Shen (Source: Frontiers in Immunology)
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The Change of Teleost Skin Commensal Microbiota Is Associated With Skin Mucosal Transcriptomic Responses During Parasitic Infection by Ichthyophthirius multifillis
Xiaoting Zhang, Liguo Ding, Yongyao Yu, Weiguang Kong, Yaxing Yin, Zhenyu Huang, Xuezhen Zhang, Zhen Xu (Source: Frontiers in Immunology)
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Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1 α Promotes Viral Proliferation
Peidian Shi, Yanxin Su, Ruiqiao Li, Lei Zhang, Chen Chen, Lilin Zhang, Kay Faaberg, Jinhai Huang (Source: Frontiers in Immunology)
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Oral Passive Immunization With Plasma-Derived Polyreactive Secretory-Like IgA/M Partially Protects Mice Against Experimental Salmonellosis
Blaise Corth ésy, Justine Monnerat, Marius Lötscher, Cédric Vonarburg, Alexander Schaub, Gilles Bioley (Source: Frontiers in Immunology)
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Sex Bias in Asthma Prevalence and Pathogenesis
Ruchi Shah, Dawn C. Newcomb (Source: Frontiers in Immunology)
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Shrimp miR-1000 Functions in Antiviral Immunity by Simultaneously Triggering the Degradation of Two Viral mRNAs
Yi Gong, Chenyu Ju, Xiaobo Zhang (Source: Frontiers in Immunology)
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High levels of Eomes promote exhaustion of anti-tumor CD8+ T cells
Jing Li, Yi He, Jing Hao, Ling Ni, Chen Dong (Source: Frontiers in Immunology)
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IREDELL WATER TESTING: Chemical linked to thyroid issues detected in water at Lake Normal High School, expert says | WSOC-TV - WSOC Charlotte
Channel 9 obtained a copy of the water and air test results from the Iredell-Statesville School District.
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Do Larger Thyroid Tumors Mean Higher Rates of Malignancy and False-Negative FNA Results? - Cancer Network
The authors looked at whether rates of malignancy and false-negative fine-needle aspiration results are heightened in large thyroid nodules.
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IREDELL WATER TESTING: Chemical linked to thyroid issues detected in water at Lake Normal High School, expert says | WSOC-TV - WSOC Charlotte
Channel 9 obtained a copy of the water and air test results from the Iredell-Statesville School District.
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Do Larger Thyroid Tumors Mean Higher Rates of Malignancy and False-Negative FNA Results? - Cancer Network
The authors looked at whether rates of malignancy and false-negative fine-needle aspiration results are heightened in large thyroid nodules.
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< i > Acanthamoeba < /i > profilin elicits allergic airway inflammation in mice
ConclusionIn this study, we demonstrated that rAc-PF may be an allergen inAcanthamoeba, but further studies needed to identify the mechanisms of allergenic reactions induced by Ac-PF. (Source: PLoS Neglected Tropical Diseases)
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Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection
Conclusions/SignificanceThese data demonstrate significant differences in pre-existing immune responses to DENV associated with the clinical outcome of subsequent infection. The finding of higher levels of some cytokines in subjects with symptomatic infection and higher levels of other cytokines in subjects with subclinical infection supports the existence of both protective and pathologic immune profiles. Clinical-immunological correlations identified in the context of natural DENV infection may be useful for evaluating immune responses to dengue vaccines. (Source: PLoS Neglected Tropical Diseases)
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Why Jo's cafe is a refuge from life's hardships - Stuff.co.nz
A year ago, Joanne Watson turned the downstairs of her historic home in a tiny Taranaki town into a cafe - and says it's one of the best decisions she's ever ...
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Survivors of childhood Hodgkin lymphoma face ongoing risk for solid cancers - Healio
Adults who survived childhood Hodgkin lymphoma have a continued risk for subsequent malignant neoplasms, according to findings published in Cancer.
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< i > Acanthamoeba < /i > profilin elicits allergic airway inflammation in mice
ConclusionIn this study, we demonstrated that rAc-PF may be an allergen inAcanthamoeba, but further studies needed to identify the mechanisms of allergenic reactions induced by Ac-PF. (Source: PLoS Neglected Tropical Diseases)
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Survivors of childhood Hodgkin lymphoma face ongoing risk for solid cancers - Healio
Adults who survived childhood Hodgkin lymphoma have a continued risk for subsequent malignant neoplasms, according to findings published in Cancer.
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Differential expression of immune markers in the patients with obstructive sleep apnea/hypopnea syndrome
Abstract
Purpose
To evaluate phenotypic changes of various immune cells in the peripheral blood in the patients with sleep apnea/hypopnea syndrome (OSAHS).
Methods
This is a case–control study. The peripheral venous blood was collected. A subset of T cells, B cells, natural killer cells, and dendritic cells was analysed using various markers and flow cytometry. Regression curve analysis was made to examine the correlation between the change of immune cells and aponea hypoxia index (AHI) and oxygen desaturation.
Results
The percentage of CD3+/CD4+ T lymphocytes (P < 0.001) and CD19+ B cells (P < 0.001) and the CD4+/CD8+ ratio (P < 0.001) in the OSAHS patients were significantly increased compared with those in the control group without OSAHS, and CD4+/CD8+ ratio positively correlated with aponea hypoxia index (r = 0.37, P < 0.001) but negatively correlated with the lowest SaO2 (r = − 0.2, P < 0.001), whereas a greater reduction in the percentage of CD3+/CD8+ T cells (P < 0.001). Moreover, the ratios of CD3+/CD16+/CD56+ natural killer (NK)-like T cells (P < 0.05) and CD3−/CD16+/CD56+ NKT cells (P < 0.001) were significantly lower in the OSAHS group than those in the control group. However, no significant difference was observed in the percentage of CD3+ total T cells, CD8+/CD28+ T cells, CD8+/CD28− T cells, DC1, DC2, and DC1/DC2 dendritic cells between the OSAHS and control groups.
Conclusion
Our study showed differential responses of various types of immune cells in the peripheral blood in patients with OSAHS and their correlation with severity of oxygen desaturation.
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Differential expression of immune markers in the patients with obstructive sleep apnea/hypopnea syndrome
Abstract
Purpose
To evaluate phenotypic changes of various immune cells in the peripheral blood in the patients with sleep apnea/hypopnea syndrome (OSAHS).
Methods
This is a case–control study. The peripheral venous blood was collected. A subset of T cells, B cells, natural killer cells, and dendritic cells was analysed using various markers and flow cytometry. Regression curve analysis was made to examine the correlation between the change of immune cells and aponea hypoxia index (AHI) and oxygen desaturation.
Results
The percentage of CD3+/CD4+ T lymphocytes (P < 0.001) and CD19+ B cells (P < 0.001) and the CD4+/CD8+ ratio (P < 0.001) in the OSAHS patients were significantly increased compared with those in the control group without OSAHS, and CD4+/CD8+ ratio positively correlated with aponea hypoxia index (r = 0.37, P < 0.001) but negatively correlated with the lowest SaO2 (r = − 0.2, P < 0.001), whereas a greater reduction in the percentage of CD3+/CD8+ T cells (P < 0.001). Moreover, the ratios of CD3+/CD16+/CD56+ natural killer (NK)-like T cells (P < 0.05) and CD3−/CD16+/CD56+ NKT cells (P < 0.001) were significantly lower in the OSAHS group than those in the control group. However, no significant difference was observed in the percentage of CD3+ total T cells, CD8+/CD28+ T cells, CD8+/CD28− T cells, DC1, DC2, and DC1/DC2 dendritic cells between the OSAHS and control groups.
Conclusion
Our study showed differential responses of various types of immune cells in the peripheral blood in patients with OSAHS and their correlation with severity of oxygen desaturation.
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Prescribing Therapy for Hypothyroidism: Influence of Physician Characteristics
Thyroid, Ahead of Print.
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Iodine Status of Pregnant Women and Women of Reproductive Age in the United States
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LrxpRK
A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rK0AWM
Prescribing Therapy for Hypothyroidism: Influence of Physician Characteristics
Thyroid, Ahead of Print.
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Iodine Status of Pregnant Women and Women of Reproductive Age in the United States
Thyroid, Ahead of Print.
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A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy
Thyroid, Ahead of Print.
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Prescribing Therapy for Hypothyroidism: Influence of Physician Characteristics
Thyroid, Ahead of Print.
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Iodine Status of Pregnant Women and Women of Reproductive Age in the United States
Thyroid, Ahead of Print.
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A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy
Thyroid, Ahead of Print.
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US, Rwanda medical professionals prepare for opening of first radiation oncology center - U.S. Africa Command
U.S. medical personnel worked hand-in-hand with their corresponding Rwandan counterparts to give cancer patients and their families renewed hope of ...
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Iodine Status of Pregnant Women and Women of Reproductive Age in the United States
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LrxpRK
A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rK0AWM
US, Rwanda medical professionals prepare for opening of first radiation oncology center - U.S. Africa Command
U.S. medical personnel worked hand-in-hand with their corresponding Rwandan counterparts to give cancer patients and their families renewed hope of ...
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St. Johns County firefighters receive specialty hoods - WOKV
The nonprofit organization Hoods For Heroes has donated $40000 worth of specialty hoods in an effort to protect firefighters in St. Johns County from ...
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Cell Separation and Characterization in Solid Tumors: Global Markets Through 2023 - PRNewswire
NEW YORK, Dec. 17, 2018 /PRNewswire/ -- Report Scope: This report consists of the overall analysis of the market landscape.It provides in-depth analysis on...
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Turkey chooses locally made biotech drug to fight cancer - Daily Sabah
Turkey's initiative to promote domestic and national products now includes a new biotechnological drug against cancer which will be ready for trial in 2019.
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St. Johns County firefighters receive specialty hoods - WOKV
The nonprofit organization Hoods For Heroes has donated $40000 worth of specialty hoods in an effort to protect firefighters in St. Johns County from ...
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Turkey chooses locally made biotech drug to fight cancer - Daily Sabah
Turkey's initiative to promote domestic and national products now includes a new biotechnological drug against cancer which will be ready for trial in 2019.
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Cell Separation and Characterization in Solid Tumors: Global Markets Through 2023 - PRNewswire
NEW YORK, Dec. 17, 2018 /PRNewswire/ -- Report Scope: This report consists of the overall analysis of the market landscape.It provides in-depth analysis on...
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US, Rwanda medical professionals prepare for opening of first radiation oncology center - DVIDS
KIGALI, Rwanda — U.S. medical personnel worked hand-in-hand with their corresponding Rwandan counterparts to give cancer patients and their families ...
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US, Rwanda medical professionals prepare for opening of first radiation oncology center - DVIDS
KIGALI, Rwanda — U.S. medical personnel worked hand-in-hand with their corresponding Rwandan counterparts to give cancer patients and their families ...
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IREDELL WATER TESTING: Chemical linked to thyroid issues detected in water at Lake Normal High School, expert says | WSOC-TV - WSOC Charlotte
Channel 9 obtained a copy of the water and air test results from the Iredell-Statesville School District.
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Table of contents
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IREDELL WATER TESTING: Chemical linked to thyroid issues detected in water at Lake Normal High School, expert says | WSOC-TV - WSOC Charlotte
Channel 9 obtained a copy of the water and air test results from the Iredell-Statesville School District.
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Table of contents
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Clinicopathologic study on a rare variant of ameloblastoma with basal cell features
Abstract
Objectives
To investigate the clinical features, pathologic manifestations, and biologic behaviors of a variant of ameloblastoma with basal cell features (AM‐BC).
Materials And Methods
Following retrospective review of the clinical and pathological data of six cases of AM‐BC, we described their histologic and immunohistochemical (IHC) features, and discussed the biologic behaviors, prognoses, pathogenesis, and clinical relevance of AM‐BC. Direct sequencing of polymerase chain reaction products was also performed in all cases.
Results
The six cases of AM‐BC involved four women and two men, aged 22–82 years. Four lesions occurred in the maxilla and two in the mandible. Histologically, the basal cells tended to be arranged as unequally‐sized follicles, strands, or cords of odontogenic epithelium in the connective tissue stroma. Little or no stellate reticulum was present in the central portion of the nest. Expression of CKs was consistent with other histological variants of ameloblastoma (AM), but AM‐BC had significantly higher p53 and Ki‐67 (P<0.05) labeling indices than other histological variants of AM. Two patients had BRAF gene mutations.
Conclusion
AM‐BC is a very rare variant of AM. Our study showed the differences and relationships that exist between AM‐BC and other variants of AM, which could enhance understanding of AM‐BC.
This article is protected by copyright. All rights reserved.
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Effects of Xerostom® products on xerostomia in primary Sjögren's syndrome: a randomised clinical trial
Abstract
Objectives
To assess the effects of Xerostom® toothpaste and mouthwash in Primary Sjögren's syndrome (pSS) patients with xerostomia.
Subjects and Methods
A double‐blinded, randomized study where patients were assigned at baseline test or control products. Patients used the products 3 times/day/28 days. We used a Visual Analog Scale (VAS) for xerostomia and an Oral Health Impact Profile‐14 (OHIP‐14), baseline and after treatment, to assess possible improvement.
Results
A total of 28 patients with pSS were included in this study, but only 24 finished it (all women, mean age 55.21±11.87), 13 patients received the test and 11 the control. VAS and OHIP‐14 scores decreased in both groups after treatment but significant differences between groups were not found. We do not detect VAS intragroup significant differences before and after treatment in test and control groups. A significant improvement in OHIP‐14 was identified in the treatment group, while no significant differences were observed in the control group. No adverse effects were present.
Conclusions
Xerostom® toothpaste and mouthrinse may alleviate and improve quality of life without associated side effects, but further research with a larger number of participants and follow‐up are necessary to establish the positive efficacy of these topical products in pSS patients.
This article is protected by copyright. All rights reserved.
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Clinicopathologic study on a rare variant of ameloblastoma with basal cell features
Abstract
Objectives
To investigate the clinical features, pathologic manifestations, and biologic behaviors of a variant of ameloblastoma with basal cell features (AM‐BC).
Materials And Methods
Following retrospective review of the clinical and pathological data of six cases of AM‐BC, we described their histologic and immunohistochemical (IHC) features, and discussed the biologic behaviors, prognoses, pathogenesis, and clinical relevance of AM‐BC. Direct sequencing of polymerase chain reaction products was also performed in all cases.
Results
The six cases of AM‐BC involved four women and two men, aged 22–82 years. Four lesions occurred in the maxilla and two in the mandible. Histologically, the basal cells tended to be arranged as unequally‐sized follicles, strands, or cords of odontogenic epithelium in the connective tissue stroma. Little or no stellate reticulum was present in the central portion of the nest. Expression of CKs was consistent with other histological variants of ameloblastoma (AM), but AM‐BC had significantly higher p53 and Ki‐67 (P<0.05) labeling indices than other histological variants of AM. Two patients had BRAF gene mutations.
Conclusion
AM‐BC is a very rare variant of AM. Our study showed the differences and relationships that exist between AM‐BC and other variants of AM, which could enhance understanding of AM‐BC.
This article is protected by copyright. All rights reserved.
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Effects of Xerostom® products on xerostomia in primary Sjögren's syndrome: a randomised clinical trial
Abstract
Objectives
To assess the effects of Xerostom® toothpaste and mouthwash in Primary Sjögren's syndrome (pSS) patients with xerostomia.
Subjects and Methods
A double‐blinded, randomized study where patients were assigned at baseline test or control products. Patients used the products 3 times/day/28 days. We used a Visual Analog Scale (VAS) for xerostomia and an Oral Health Impact Profile‐14 (OHIP‐14), baseline and after treatment, to assess possible improvement.
Results
A total of 28 patients with pSS were included in this study, but only 24 finished it (all women, mean age 55.21±11.87), 13 patients received the test and 11 the control. VAS and OHIP‐14 scores decreased in both groups after treatment but significant differences between groups were not found. We do not detect VAS intragroup significant differences before and after treatment in test and control groups. A significant improvement in OHIP‐14 was identified in the treatment group, while no significant differences were observed in the control group. No adverse effects were present.
Conclusions
Xerostom® toothpaste and mouthrinse may alleviate and improve quality of life without associated side effects, but further research with a larger number of participants and follow‐up are necessary to establish the positive efficacy of these topical products in pSS patients.
This article is protected by copyright. All rights reserved.
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"Allergic-like" reaction risk in patients undergoing non-intravenous contrast urography.
CONCLUSION: Despite commonly voiced concerns, in this large series of over 2,500 patients, including 113 patients with a prior history of ICA undergoing contrast urography, only one patient was found to have a potential ALR event following PCNL. No patients undergoing a retrograde contrast urography with prior, documented ICA had a NIVC ALR event despite a low rate of pretreatment with corticosteroid or antihistamine. PMID: 30553286 [PubMed - in process] (Source: Canadian Journal of Urology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Genotype‐phenotype correlations in Brazilian patients with Hereditary Angioedema due to C1‐ inhibitor deficiency
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"Allergic-like" reaction risk in patients undergoing non-intravenous contrast urography.
CONCLUSION: Despite commonly voiced concerns, in this large series of over 2,500 patients, including 113 patients with a prior history of ICA undergoing contrast urography, only one patient was found to have a potential ALR event following PCNL. No patients undergoing a retrograde contrast urography with prior, documented ICA had a NIVC ALR event despite a low rate of pretreatment with corticosteroid or antihistamine. PMID: 30553286 [PubMed - in process] (Source: Canadian Journal of Urology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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GSE114407 Cell type specific gene expression patterns associated with posttraumatic stress disorder in World Trade Center responders
The objective of this study was to utilize RNA sequencing to simultaneously profile the gene-expression of four immune cell subpopulations in World Trade Center responders. Pathway analyses identified gene sets related to immune response and inflammation as being among the differentially expressed genes in PTSD, including mast cell activation and regulation in CD4T, interferon-beta production in CD8T, and neutrophil related gene sets in monocytes. These findings are suggestive that immune cell dysregulation involves gene expression in various cell populations. (Source: GEO: Gene Expression Omnibus)
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Genotype‐phenotype correlations in Brazilian patients with Hereditary Angioedema due to C1‐ inhibitor deficiency
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IREDELL WATER TESTING: Chemical linked to thyroid issues detected in water at Lake Normal High School, expert says | WSOC-TV - WSOC Charlotte
Channel 9 obtained a copy of the water and air test results from the Iredell-Statesville School District.
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IREDELL WATER TESTING: Chemical linked to thyroid issues detected in water at Lake Normal High School, expert says | WSOC-TV - WSOC Charlotte
Channel 9 obtained a copy of the water and air test results from the Iredell-Statesville School District.
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Quantitative susceptibility mapping detects neovascularization of the epiphyseal cartilage after ischemic injury in a piglet model of legg‐calvé‐perthes disease
Background
Legg‐Calvé‐Perthes disease (LCPD) is a childhood hip disorder thought to be caused by disruption of blood supply to the developing femoral head. There is potential for imaging to help assess revascularization of the femoral head.
Purpose
To investigate whether quantitative susceptibility mapping (QSM) can detect neovascularization in the epiphyseal cartilage following ischemic injury to the developing femoral head.
Study Type
Prospective.
Animal Model
Right femoral head ischemia was surgically induced in 6‐week‐old male piglets. The animals were sacrificed 48 hours (n = 3) or 4 weeks (n = 7) following surgery, and the operated and contralateral control femoral heads were harvested for ex vivo MRI.
Field Strength/Sequence
Preclinical 9.4T MRI to acquire susceptibility‐weighted 3D gradient echo (GRE) images with 0.1 mm isotropic spatial resolution.
Assessment
The 3D GRE images were used to manually segment the cartilage overlying the femoral head and were subsequently postprocessed using QSM. Vessel volume, cartilage volume, and vessel density were measured and compared between operated and control femoral heads at each timepoint. Maximum intensity projections of the QSM images were subjectively assessed to identity differences in cartilage canal appearance, location, and density.
Statistical Tests
Paired t‐tests with Bonferroni correction were used (P < 0.008 considered significant).
Results
Increased vascularity of the epiphyseal cartilage following ischemic injury was clearly identified using QSM. No changes were detected 48 hours after surgery. Vessel volume, cartilage volume, and vessel density were all increased in the operated vs. control femoral heads 4 weeks after surgery (P = 0.001, 0.002, and 0.001, respectively). Qualitatively, the increase in vessel density at 4 weeks was due to the formation of new vessels that were organized in a brush‐like orientation in the epiphyseal cartilage, consistent with the histological appearance of neovascularization.
Data Conclusion
QSM can detect neovascularization in the epiphyseal cartilage following ischemic injury to the femoral head.
Level of Evidence: 1
Technical Efficacy: Stage 1
J. Magn. Reson. Imaging 2018.
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Clinical Thyroidology® for the Public – Highlighted Article
From Clinical Thyroidology® for the Public: Higher iodine intake in the mother during pregnancy is associated with higher child IQ. Read More…
We welcome your feedback and suggestions. Let us know what you want to see in this publication.
Feedback & SuggestionsThe post Clinical Thyroidology<sup>®</sup> for the Public – Highlighted Article appeared first on American Thyroid Association.
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Quantitative susceptibility mapping detects neovascularization of the epiphyseal cartilage after ischemic injury in a piglet model of legg‐calvé‐perthes disease
Background
Legg‐Calvé‐Perthes disease (LCPD) is a childhood hip disorder thought to be caused by disruption of blood supply to the developing femoral head. There is potential for imaging to help assess revascularization of the femoral head.
Purpose
To investigate whether quantitative susceptibility mapping (QSM) can detect neovascularization in the epiphyseal cartilage following ischemic injury to the developing femoral head.
Study Type
Prospective.
Animal Model
Right femoral head ischemia was surgically induced in 6‐week‐old male piglets. The animals were sacrificed 48 hours (n = 3) or 4 weeks (n = 7) following surgery, and the operated and contralateral control femoral heads were harvested for ex vivo MRI.
Field Strength/Sequence
Preclinical 9.4T MRI to acquire susceptibility‐weighted 3D gradient echo (GRE) images with 0.1 mm isotropic spatial resolution.
Assessment
The 3D GRE images were used to manually segment the cartilage overlying the femoral head and were subsequently postprocessed using QSM. Vessel volume, cartilage volume, and vessel density were measured and compared between operated and control femoral heads at each timepoint. Maximum intensity projections of the QSM images were subjectively assessed to identity differences in cartilage canal appearance, location, and density.
Statistical Tests
Paired t‐tests with Bonferroni correction were used (P < 0.008 considered significant).
Results
Increased vascularity of the epiphyseal cartilage following ischemic injury was clearly identified using QSM. No changes were detected 48 hours after surgery. Vessel volume, cartilage volume, and vessel density were all increased in the operated vs. control femoral heads 4 weeks after surgery (P = 0.001, 0.002, and 0.001, respectively). Qualitatively, the increase in vessel density at 4 weeks was due to the formation of new vessels that were organized in a brush‐like orientation in the epiphyseal cartilage, consistent with the histological appearance of neovascularization.
Data Conclusion
QSM can detect neovascularization in the epiphyseal cartilage following ischemic injury to the femoral head.
Level of Evidence: 1
Technical Efficacy: Stage 1
J. Magn. Reson. Imaging 2018.
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Clinical Thyroidology® for the Public – Highlighted Article
From Clinical Thyroidology® for the Public: Higher iodine intake in the mother during pregnancy is associated with higher child IQ. Read More…
We welcome your feedback and suggestions. Let us know what you want to see in this publication.
Feedback & SuggestionsThe post Clinical Thyroidology<sup>®</sup> for the Public – Highlighted Article appeared first on American Thyroid Association.
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Thyroid disorders may worsen heart failure : Circulation Study - Specialty Medical Dialogues
Pennsylvania, Philadelphia: Thyroid disorders -- low T3 syndrome and subclinical hypothyroidism – might worsen heart failure, finds a new study published in ...
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Thyroid disorders may worsen heart failure : Circulation Study - Specialty Medical Dialogues
Pennsylvania, Philadelphia: Thyroid disorders -- low T3 syndrome and subclinical hypothyroidism – might worsen heart failure, finds a new study published in ...
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Global Poly Polymerase 2 Market describes its growth, size, share, Forecast and trends to 2025 - Market News Insights
Global Poly Polymerase 2 market was estimated at USD xx million in 2017 and expected to reach USD X.XX million by the end of 2025, growing at a CAGR of ...
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Liz hits her target - Liverpool City Champion
It would be remiss not to use an archery term to describe Elizabeth Hole's magical 2018 – especially when it sums it up so perfectly.
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IREDELL WATER TESTING: Chemical linked to thyroid issues detected in water at Lake Normal High School, expert says | WSOC-TV - WSOC Charlotte
Channel 9 obtained a copy of the water and air test results from the Iredell-Statesville School District.
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LetsGetChecked Provides Easy At-Home Lab Testing and Consultations | - Medgadget
At-home lab tests are growing in popularity. While many companies focus on specific tests, such as genetic testing or specific screenings, LetsGetChecked,
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European Commission Approves Merck's KEYTRUDA® (pembrolizumab) as Adjuvant Therapy for Adults with Resected Stage III Melanoma - Associated Press
KENILWORTH, N.J.--(BUSINESS WIRE)--Dec 17, 2018--Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the ...
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Study of coronary angiographic correlation with electrocardiography in patients of acute coronary syndrome-ST-elevation myocardial infarction
Heart India 2018 6(4):115-122
Background: Abnormalities in the 12-lead electrocardiography (ECG) are often used to localize the anatomic site of myocardial infarction (MI) and ischemia in patients with coronary artery disease. The same ECG findings are often assumed to correlate with anatomy of coronary arteries as well as the site of occlusion. Unfortunately, there is only limited documentation for correlation between the location of coronary artery occlusion and the finding of Q-waves during MI, thus tending to compromise the predictive value of ECG. Aims and Objectives: The objective of this study is to correlate the accuracy of ECG in localization of culprit coronary vessels involved in acute coronary syndrome-ST-elevation myocardial infarction (ACS-STEMI) and to combine various ECG criteria for localization of culprit vessel and the occlusion site to assess the diagnostic accuracy of ECG as compared to coronary angiographic findings. Materials and Methods: ECGs of patients with MI events, symptomatic or silent, were analyzed for STEMI or non-STEMI. One hundred patients with STEMI satisfying the inclusion and exclusion criteria were included as participants for the study. Coronary angiography was done after an event of acute MI or within 3 months after an event. ECG changes in various leads were used to localize the vessel involved and were correlated with dominant vessel involved in coronary angiography in development of MI. ECG criteria were used to localize the vessel involved. The statistical analysis was done using SPSS for windows version 16.0 software. Results and conclusions: We found that anterior wall myocardial infarction was more common than inferior wall myocardial infarction. Incidence of MI correlated positively with age. Acute MI was more common in males than females. Diabetes was more common risk factor for acute MI. ECG criteria utilized in our study were found to have high sensitivity and specificity, when combined together, in localizing culprit vessel in ACS-STEMI in left anterior descending artery, right coronary artery, and left circumflex coronary artery and this is in accordance with the studies conducted in other populations.
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A case of familial hypercholesterolemia with premature coronary artery disease
Heart India 2018 6(4):156-159
Familial hypercholesterolemia (FH) is a form of genetic dyslipidemia characterized by high levels of serum low-density lipoprotein cholesterol, tendon xanthomas, and family history of heart disease or elevated cholesterol. We report the case of a 24-year-old young male who presented with acute coronary syndrome, multiple skin and tendon xanthomas, family history of premature cardiac death and diagnosed as FH with coronary artery disease which was treated with percutaneous coronary intervention and lipid-lowering therapy.
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Mean platelet volume in acute coronary syndrome: Diagnostic implications
Heart India 2018 6(4):123-126
Objective: The aim of the present study was to investigate the association between mean platelet volume (MPV) and platelet count in patients with diagnosis of acute coronary syndrome (ACS). Materials and Methods: It was a case–control study conducted in a tertiary care hospital. We examined 100 cases of ACS and 100 age- and sex-matched healthy controls. All patients were subjected to focused history, focused clinical examination, vital recording, and baseline 12 lead electrocardiogram. MPV and platelet count were measured by a hemogram device, Melet Schloesing (MS-9) based on the Coulter principle. Results: The patients with ACS had a higher MPV 7.70 fl as compared to the normal healthy controls 6.64 fl (P < 0.0001). On the other hand, the platelet count was significantly decreased in the patients of ACS 172.44 × 109/L when compared with the healthy control group 204.98 × 109/L, and this difference was statistically significant with P < 0.0001. Conclusions: We concluded that the patients presenting with features of ACS have a higher MPV and a decreased platelet count as compared to normal population. These simple hematological markers such as MPV and platelet count can help us in reaching the diagnosis of ACS along with traditional tools.
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A comparison of outcomes with adjunctive and delayed routine pharmacoinvasive percutaneous coronary intervention strategy after thrombolysis in patients with ST-elevation myocardial infarction: Experience from a tertiary-care center in India
Heart India 2018 6(4):141-147
Objective: Since primary percutaneous coronary intervention (PCI) is not readily available to many patients either due to financial issue or unavailability of invasive cath labs, pharmacoinvasive strategies are now becoming the de facto treatment strategy. The most commonly used strategies are adjunctive PCI (within 3–24 h of thrombolysis) and delayed routine PCI (>24 h to before hospital discharge). However, direct comparison of these two strategies is lacking. Materials and Methods: In this prospective, observational, single-center study, a total of 113 thrombolysed ST-segment elevation myocardial infarction (STEMI) patients in the adjunctive PCI group and 127 thrombolysed STEMI patients in the delayed routine PCI group were analyzed. At 30-day follow-up, patients were evaluated for all-cause mortality, reinfarction, hospitalization due to angina, hospitalization due to heart failure, and improvement in left ventricular (LV) ejection fraction. Results: Patients in the adjunctive PCI group and those in the delayed routine PCI group exhibited comparable baseline characteristics. At 30-day follow up, no significant difference was noted in all-cause mortality, reinfarction, hospitalization due to angina, and hospitalization due to heart failure. There was slight trend toward increased composite end-points in the adjunctive PCI group, probably favoring delayed routine PCI (8.85% vs. 4.72%; P = 0.450). There was no significant difference in improvement in LV ejection fraction between two groups (P = 0.671). Conclusions: Even after 24 h of thrombolytic treatment in STEMI patients, delayed routine PCI can be performed with comparable outcome to that of PCI within 24 h.
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Pacemaker lead fracture as a cause of pacing failure
Heart India 2018 6(4):153-155
Cardiac pacing is a rapidly advancing technique. There are many potential complications of pacemaker implantation. In view of increasing implantations of pacemakers, we must have some insight of possible complications. We describe here a case of pacing lead fracture which was managed by new lead implantation.
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Study of clinical profile, incidence, pattern, and atherosclerotic involvement of congenital coronary artery anomalies in adults undergoing coronary angiography: A study from a tertiary care institute in western part of India
Heart India 2018 6(4):133-140
Objective: Congenital coronary artery anomalies (CCAs) are rare, clinically benign, and majority are diagnosed incidentally during coronary angiography or an autopsy. Identification of CCA is important for management by cardiologists or cardiac surgeons, and also few cases of CCA are potentially serious which may cause sudden cardiac death. We performed a retrospective, single-center study to evaluate the clinical profile, incidence, pattern, and atherosclerotic involvement of CCA in patients undergoing coronary angiography. Methods: Coronary angiographies performed in adult patients during the study period of 2 years were screened for CCA. These patients were retrospectively analyzed in terms of clinical characteristics and angiographic profiles. Results: Of 4481 angiograms screened, 86 patients were found to have CCA with the incidence of 1.91%. Nearly 76.7% were male and 23.3% were female, with a mean age of 53.02 ± 10 years. Anomalies of origin and course were most common (94.18%) followed by anomalies of termination (5.81%), with right coronary artery (RCA) being the most common artery. Anomalous origin of RCA from the left sinus of Valsalva and separate origin of left anterior descending artery and left circumflex artery were both found to be the most common types. The incidence of atherosclerosis in anomalous vessels was 52.32%. Conclusions: CCAs were diagnosed incidentally during coronary angiography and had male predominance with conventional risk factors. The incidence of CCA was slightly higher than that of the previous angiographic studies, but the pattern of anomalies was similar with majority being benign. Anomalous vessels did not predispose to atherosclerotic involvement as compared to normal vessels in the same patients.
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IREDELL WATER TESTING: Chemical linked to thyroid issues detected in water at Lake Normal High School, expert says | WSOC-TV - WSOC Charlotte
Channel 9 obtained a copy of the water and air test results from the Iredell-Statesville School District.
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LetsGetChecked Provides Easy At-Home Lab Testing and Consultations | - Medgadget
At-home lab tests are growing in popularity. While many companies focus on specific tests, such as genetic testing or specific screenings, LetsGetChecked,
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European Commission Approves Merck's KEYTRUDA® (pembrolizumab) as Adjuvant Therapy for Adults with Resected Stage III Melanoma - Associated Press
KENILWORTH, N.J.--(BUSINESS WIRE)--Dec 17, 2018--Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the ...
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A rolling ball like mass in right atrium of a 6 year old child
Heart India 2018 6(4):148-152
Cardiac myxoma is a common tumor occurring more commonly in the left atrium in adult females. Its occurrence in pediatric age group is rare; the more common tumors are rhabdomyoma and fibroma. Presentation of myxoma on the right side is still rarer in this age group. We report a case of a 6-year-old male child who presented with prolonged fever. On examination, there is an extra diastolic sound with mid-diastolic murmur. Echocardiogram is suggestive of a large ball-like polypoidal mass rolling in the right atrium traversing into the right ventricle. The case was immediately operated, and histopathology confirmed the tumor as myxoma. High index of suspicion is required to diagnose the condition to prevent disastrous complications as the presentation is often enigmatic because of vague constitutional findings in most of the cases.
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Treatment of long coronary lesions with single stent: BioMime Morph sirolimus-eluting tapered coronary stent system
Heart India 2018 6(4):113-114
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Preface to fourth issue of Heart India 2018
Heart India 2018 6(4):111-112
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Study of coronary angiographic correlation with electrocardiography in patients of acute coronary syndrome-ST-elevation myocardial infarction
Heart India 2018 6(4):115-122
Background: Abnormalities in the 12-lead electrocardiography (ECG) are often used to localize the anatomic site of myocardial infarction (MI) and ischemia in patients with coronary artery disease. The same ECG findings are often assumed to correlate with anatomy of coronary arteries as well as the site of occlusion. Unfortunately, there is only limited documentation for correlation between the location of coronary artery occlusion and the finding of Q-waves during MI, thus tending to compromise the predictive value of ECG. Aims and Objectives: The objective of this study is to correlate the accuracy of ECG in localization of culprit coronary vessels involved in acute coronary syndrome-ST-elevation myocardial infarction (ACS-STEMI) and to combine various ECG criteria for localization of culprit vessel and the occlusion site to assess the diagnostic accuracy of ECG as compared to coronary angiographic findings. Materials and Methods: ECGs of patients with MI events, symptomatic or silent, were analyzed for STEMI or non-STEMI. One hundred patients with STEMI satisfying the inclusion and exclusion criteria were included as participants for the study. Coronary angiography was done after an event of acute MI or within 3 months after an event. ECG changes in various leads were used to localize the vessel involved and were correlated with dominant vessel involved in coronary angiography in development of MI. ECG criteria were used to localize the vessel involved. The statistical analysis was done using SPSS for windows version 16.0 software. Results and conclusions: We found that anterior wall myocardial infarction was more common than inferior wall myocardial infarction. Incidence of MI correlated positively with age. Acute MI was more common in males than females. Diabetes was more common risk factor for acute MI. ECG criteria utilized in our study were found to have high sensitivity and specificity, when combined together, in localizing culprit vessel in ACS-STEMI in left anterior descending artery, right coronary artery, and left circumflex coronary artery and this is in accordance with the studies conducted in other populations.
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Mean platelet volume in acute coronary syndrome: Diagnostic implications
Heart India 2018 6(4):123-126
Objective: The aim of the present study was to investigate the association between mean platelet volume (MPV) and platelet count in patients with diagnosis of acute coronary syndrome (ACS). Materials and Methods: It was a case–control study conducted in a tertiary care hospital. We examined 100 cases of ACS and 100 age- and sex-matched healthy controls. All patients were subjected to focused history, focused clinical examination, vital recording, and baseline 12 lead electrocardiogram. MPV and platelet count were measured by a hemogram device, Melet Schloesing (MS-9) based on the Coulter principle. Results: The patients with ACS had a higher MPV 7.70 fl as compared to the normal healthy controls 6.64 fl (P < 0.0001). On the other hand, the platelet count was significantly decreased in the patients of ACS 172.44 × 109/L when compared with the healthy control group 204.98 × 109/L, and this difference was statistically significant with P < 0.0001. Conclusions: We concluded that the patients presenting with features of ACS have a higher MPV and a decreased platelet count as compared to normal population. These simple hematological markers such as MPV and platelet count can help us in reaching the diagnosis of ACS along with traditional tools.
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A comparison of outcomes with adjunctive and delayed routine pharmacoinvasive percutaneous coronary intervention strategy after thrombolysis in patients with ST-elevation myocardial infarction: Experience from a tertiary-care center in India
Heart India 2018 6(4):141-147
Objective: Since primary percutaneous coronary intervention (PCI) is not readily available to many patients either due to financial issue or unavailability of invasive cath labs, pharmacoinvasive strategies are now becoming the de facto treatment strategy. The most commonly used strategies are adjunctive PCI (within 3–24 h of thrombolysis) and delayed routine PCI (>24 h to before hospital discharge). However, direct comparison of these two strategies is lacking. Materials and Methods: In this prospective, observational, single-center study, a total of 113 thrombolysed ST-segment elevation myocardial infarction (STEMI) patients in the adjunctive PCI group and 127 thrombolysed STEMI patients in the delayed routine PCI group were analyzed. At 30-day follow-up, patients were evaluated for all-cause mortality, reinfarction, hospitalization due to angina, hospitalization due to heart failure, and improvement in left ventricular (LV) ejection fraction. Results: Patients in the adjunctive PCI group and those in the delayed routine PCI group exhibited comparable baseline characteristics. At 30-day follow up, no significant difference was noted in all-cause mortality, reinfarction, hospitalization due to angina, and hospitalization due to heart failure. There was slight trend toward increased composite end-points in the adjunctive PCI group, probably favoring delayed routine PCI (8.85% vs. 4.72%; P = 0.450). There was no significant difference in improvement in LV ejection fraction between two groups (P = 0.671). Conclusions: Even after 24 h of thrombolytic treatment in STEMI patients, delayed routine PCI can be performed with comparable outcome to that of PCI within 24 h.
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Baseline hemoglobin and creatinine clearance as independent risk factors for 30-day event rate in patients of acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
Heart India 2018 6(4):127-132
Background: Primary percutaneous coronary intervention (PCI) is the most effective therapy for managing acute ST-segment elevation myocardial infarction (STEMI). Studies have shown baseline low hemoglobin (Hb) and reduced creatinine clearance (CrCl) as risk factors for adverse outcomes in patients with heart failure, in patients undergoing PCI, and in acute coronary syndrome. However, their similar role in patients of acute STEMI undergoing primary PCI is not known. Objective: The main objective is to study whether baseline Hb and CrCl are the independent risk factors for the 30 days event rate in patients of acute STEMI undergoing primary PCI. Methods: We prospectively studied 500 patients of acute STEMI undergoing primary PCI. Hb and CrCl were measured at baseline and then at 15th and 30th day after the event. Patients were divided into four groups based on whether they have normal or abnormal baseline Hb and CrCl. Patients were followed for 30-day postdischarge for incidence of major adverse events in the form of death, reinfarction, reintervention, and hemodynamically unstable ventricular tachyarrhythmias. We assessed correlation between baseline Hb, CrC, l and 30-day event rate among four groups using Chi-square test. Results: On comparison among groups, compared to Group 1, Group 2, 3, and 4 had significantly higher adverse events ([6.48% vs. 19.44%] [P = 0.021]), ([6.48% vs. 30%] [P = 0.0003]), ([6.48% vs. 51.66%] [P ≤ 0.0001]), respectively, at 30 days after primary PCI. Conclusion: In patients of acute STEMI undergoing primary PCI, both baseline impaired CrCl and low Hb behaved independently as risk factors for increased 30-day event rates.
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Pacemaker lead fracture as a cause of pacing failure
Heart India 2018 6(4):153-155
Cardiac pacing is a rapidly advancing technique. There are many potential complications of pacemaker implantation. In view of increasing implantations of pacemakers, we must have some insight of possible complications. We describe here a case of pacing lead fracture which was managed by new lead implantation.
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Study of clinical profile, incidence, pattern, and atherosclerotic involvement of congenital coronary artery anomalies in adults undergoing coronary angiography: A study from a tertiary care institute in western part of India
Heart India 2018 6(4):133-140
Objective: Congenital coronary artery anomalies (CCAs) are rare, clinically benign, and majority are diagnosed incidentally during coronary angiography or an autopsy. Identification of CCA is important for management by cardiologists or cardiac surgeons, and also few cases of CCA are potentially serious which may cause sudden cardiac death. We performed a retrospective, single-center study to evaluate the clinical profile, incidence, pattern, and atherosclerotic involvement of CCA in patients undergoing coronary angiography. Methods: Coronary angiographies performed in adult patients during the study period of 2 years were screened for CCA. These patients were retrospectively analyzed in terms of clinical characteristics and angiographic profiles. Results: Of 4481 angiograms screened, 86 patients were found to have CCA with the incidence of 1.91%. Nearly 76.7% were male and 23.3% were female, with a mean age of 53.02 ± 10 years. Anomalies of origin and course were most common (94.18%) followed by anomalies of termination (5.81%), with right coronary artery (RCA) being the most common artery. Anomalous origin of RCA from the left sinus of Valsalva and separate origin of left anterior descending artery and left circumflex artery were both found to be the most common types. The incidence of atherosclerosis in anomalous vessels was 52.32%. Conclusions: CCAs were diagnosed incidentally during coronary angiography and had male predominance with conventional risk factors. The incidence of CCA was slightly higher than that of the previous angiographic studies, but the pattern of anomalies was similar with majority being benign. Anomalous vessels did not predispose to atherosclerotic involvement as compared to normal vessels in the same patients.
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A case of sudden-onset painless unilateral vision loss postintravenous streptokinase in a patient of acute inferior-wall myocardial infarction
Heart India 2018 6(4):160-161
Coronary thrombolysis with intravenous (IV) streptokinase is widely used as a strategy for coronary reperfusion for acute myocardial infarction (MI). Systemic administration of fibrinolytic agents is associated with hemorrhagic risks such as cerebral hemorrhage, gastrointestinal bleeding, cardiogenic shock, and unusual complications such as splenic rupture, aortic dissection, and cholesterol embolization. Herein, we report a case of intraocular hemorrhage 1 day after the IV administration of streptokinase for acute inferior-wall MI.
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Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study
Conditions: Sleep Apnea; Allergic Rhinitis; Allergic Asthma; Pollution; Exposure; Pollution Related Respiratory Disorder Intervention: Other: Pollution exposure Sponsors: University Hospital, Grenoble; Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)
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A randomized controlled trial testing a hyaluronic acid spacer injection for skin toxicity reduction of brachytherapy accelerated partial breast irradiation (APBI): a study protocol
In this study, the effect of a subcutaneous spacer injection on the skin dose, late skin toxicity, and cosmetic outcome is tested in patients treated with PBSI in the setting of breast-conserving therapy. Our results will be relevant for most forms of breast brachytherapy as well as robotic radiosurgery, as skin spacers could protect the skin with these other techniques.Trial registrationNetherlands Trial Register,NTR6549. Registered on 27 June 2017. (Source: Trials)
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Determine Immunoglobulin G4 (IgG4) Standards for Cow's Milk and Egg in Different Populations of Allergic and Non-allergic Children
Condition: Food Allergy in Children Intervention: Biological: Blood collection Sponsor: Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)
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Development of Metabolic Syndrome in Children and Adolescents With Leukemia and Lymphomas
Condition: Metabolic Syndrome Intervention: Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology Recruiting (Source: ClinicalTrials.gov)
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Cetirizine Chewable Bioequivalence and Food Effect Study
Condition: Allergy Interventions: Drug: Cetirizine 10mg; Drug: Cetirizine 10 mg Sponsor: Johnson& Johnson Consumer Inc., McNeil Consumer Healthcare Division Recruiting (Source: ClinicalTrials.gov)
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DOT Diary Mobile App for Pre-Exposure Prophylaxis Adherence in Young Men
Conditions: Adherence, Medication; Risk Behavior; Pre-Exposure Prophylaxis; HIV Prevention Interventions: Drug: Emtricitabine / Tenofovir Disoproxil Oral Tablet; Other: DOT Diary mobile app Sponsors: Public Health Foundation Enterprises, Inc.; National Institute of Mental Health (NIMH); San Francisco Department of Public Health; Emory University; AiCure; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Effect of the Nasal Gel " Nascum ®-Plus " on Allergic Symptoms
Condition: Rhinitis, Allergic, Seasonal Interventions: Drug: Nascum Plus; Other: ACC Sponsors: Fraunhofer-Institute of Toxicology and Experimental Medicine; M et P Pharma AG Enrolling by invitation (Source: ClinicalTrials.gov)
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Pilot Study of Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube
Conditions: Fallopian Tube Cancer; Fallopian Tube Infection Intervention: Drug: Aspirin 81 mg Sponsor: University of Oklahoma Not yet recruiting (Source: ClinicalTrials.gov)
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Innovation Pharmaceuticals Completes End-of-Phase 2 Meeting with FDA; Brilacidin Oral Rinse to Advance Into Phase 3 Clinical Trials for Prevention of Severe Oral Mucositis - Nasdaq
BEVERLY, Mass., Dec. 17, 2018-- Innovation Pharmaceuticals, a clinical stage pharmaceutical company, announced today that the Company and the U.S..
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Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study
Conditions: Sleep Apnea; Allergic Rhinitis; Allergic Asthma; Pollution; Exposure; Pollution Related Respiratory Disorder Intervention: Other: Pollution exposure Sponsors: University Hospital, Grenoble; Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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A randomized controlled trial testing a hyaluronic acid spacer injection for skin toxicity reduction of brachytherapy accelerated partial breast irradiation (APBI): a study protocol
In this study, the effect of a subcutaneous spacer injection on the skin dose, late skin toxicity, and cosmetic outcome is tested in patients treated with PBSI in the setting of breast-conserving therapy. Our results will be relevant for most forms of breast brachytherapy as well as robotic radiosurgery, as skin spacers could protect the skin with these other techniques.Trial registrationNetherlands Trial Register,NTR6549. Registered on 27 June 2017. (Source: Trials)
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Determine Immunoglobulin G4 (IgG4) Standards for Cow's Milk and Egg in Different Populations of Allergic and Non-allergic Children
Condition: Food Allergy in Children Intervention: Biological: Blood collection Sponsor: Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)
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Development of Metabolic Syndrome in Children and Adolescents With Leukemia and Lymphomas
Condition: Metabolic Syndrome Intervention: Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology Recruiting (Source: ClinicalTrials.gov)
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Cetirizine Chewable Bioequivalence and Food Effect Study
Condition: Allergy Interventions: Drug: Cetirizine 10mg; Drug: Cetirizine 10 mg Sponsor: Johnson& Johnson Consumer Inc., McNeil Consumer Healthcare Division Recruiting (Source: ClinicalTrials.gov)
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DOT Diary Mobile App for Pre-Exposure Prophylaxis Adherence in Young Men
Conditions: Adherence, Medication; Risk Behavior; Pre-Exposure Prophylaxis; HIV Prevention Interventions: Drug: Emtricitabine / Tenofovir Disoproxil Oral Tablet; Other: DOT Diary mobile app Sponsors: Public Health Foundation Enterprises, Inc.; National Institute of Mental Health (NIMH); San Francisco Department of Public Health; Emory University; AiCure; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Effect of the Nasal Gel " Nascum ®-Plus " on Allergic Symptoms
Condition: Rhinitis, Allergic, Seasonal Interventions: Drug: Nascum Plus; Other: ACC Sponsors: Fraunhofer-Institute of Toxicology and Experimental Medicine; M et P Pharma AG Enrolling by invitation (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Pilot Study of Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube
Conditions: Fallopian Tube Cancer; Fallopian Tube Infection Intervention: Drug: Aspirin 81 mg Sponsor: University of Oklahoma Not yet recruiting (Source: ClinicalTrials.gov)
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Non-interventional Research Clinical Research Program for Establishment of Milk Protein Allergy Oral Immune Tolerance
Condition: Milk Protein Allergy Intervention: Sponsor: Peking University Third Hospital Active, not recruiting (Source: ClinicalTrials.gov)
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Rakuten Aspyrian Enrolling Phase 3 Trial of ASP-1929 for Head and Neck Cancer - PRNewswire
SAN DIEGO, Dec. 17, 2018 /PRNewswire/ -- Rakuten Aspyrian, a biotechnology company developing precision-targeted cancer therapies based on its ...
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GMFTO: Pet of the Week! - Fetchyournews.com
Join us every Friday from Circuit World for Pet of the Week! The Humane Society of Blue Ridge has a lot of wonderful pets available for adoption.
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GMFTO: Pet of the Week! - Fetchyournews.com
Join us every Friday from Circuit World for Pet of the Week! The Humane Society of Blue Ridge has a lot of wonderful pets available for adoption.
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The importance of recognizing an association between obstructive sleep apnea and post-traumatic stress disorder (Arthur Friedlander, et al), November 2018, V76, #11
To the Editor: - The recent article in Perspectives section of the journal on recognizing an association between obstructive sleep apnea and post-traumatic stress disorder by Friedlander et al (1) was a new and interesting view on the link between two, not traditionally associated, conditions. Authors indicated the still unknown nature of this association among a selected group of patients, especially military veterans. According to presented literature, possible connections between OSA and PTSD can be attributed to either typical for OSA fragmented sleep pattern with arousals coinciding with decreased airway muscle tone that is also common for disturbing dreams and unstable upper airways of PTSD, dysfunctional REM sleep mechanism and nightmare episodes demonstrated in both disorders, and other causes.
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Investigation of An Opioid Prescribing Protocol After Third Molar Extraction Procedures
The United States is experiencing an epidemic of opioid overdoses and deaths. The relationship between prescription opioids and opioid abuse is well- documented. Oral and maxillofacial surgeons and other dentists are proportionately among the most prevalent prescribers of opioids. Practitioners are looking for evidence-based ways to decrease excess opioid prescriptions while adequately managing postoperative pain. We recently analyzed the impact of a mandated non-opioid prescribing protocol at our institution.
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The importance of recognizing an association between obstructive sleep apnea and post-traumatic stress disorder (Arthur Friedlander, et al), November 2018, V76, #11
To the Editor: - The recent article in Perspectives section of the journal on recognizing an association between obstructive sleep apnea and post-traumatic stress disorder by Friedlander et al (1) was a new and interesting view on the link between two, not traditionally associated, conditions. Authors indicated the still unknown nature of this association among a selected group of patients, especially military veterans. According to presented literature, possible connections between OSA and PTSD can be attributed to either typical for OSA fragmented sleep pattern with arousals coinciding with decreased airway muscle tone that is also common for disturbing dreams and unstable upper airways of PTSD, dysfunctional REM sleep mechanism and nightmare episodes demonstrated in both disorders, and other causes.
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Investigation of An Opioid Prescribing Protocol After Third Molar Extraction Procedures
The United States is experiencing an epidemic of opioid overdoses and deaths. The relationship between prescription opioids and opioid abuse is well- documented. Oral and maxillofacial surgeons and other dentists are proportionately among the most prevalent prescribers of opioids. Practitioners are looking for evidence-based ways to decrease excess opioid prescriptions while adequately managing postoperative pain. We recently analyzed the impact of a mandated non-opioid prescribing protocol at our institution.
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Is maxillomandibular advancement associated with comorbidity reduction in patients with obstructive sleep apnea?
In patients with documented obstructive sleep apnea (OSA) who experience reduction in AHI and self-reported symptoms after maxillomandibular advancement with genial tubercle advancement (MMA/GTA), is there also a change in the medical comorbidity profile a minimum of two years postoperatively? We are assessing for changes in: the quantity of medical diagnoses; the quantity of prescription medications; and the average weight and BMI.
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Response to Letter to the Editor - RE: Overutilization of Computed Tomography for Odontogenic Infections
I am writing in response to the Letter to the Editor by Dr. Saggese, regarding our paper titled "Overutilization of Computed Tomography for Odontogenic Infections". First, responding to your concern about our claim of no other published papers investigating computed tomography (CT) overuse for odontogenic infections, this was an accurate claim at the time of the article's initial submission.
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Steven Wayne McCracken | Obituaries - Richland Source
Steven Wayne McCracken, 66, of Galion, Ohio, passed away Friday morning, Dec. 14, 2018, surrounded by his family.
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Liz hits her target - Liverpool City Champion
It would be remiss not to use an archery term to describe Elizabeth Hole's magical 2018 – especially when it sums it up so perfectly.
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Response to Letter to the Editor - RE: Overutilization of Computed Tomography for Odontogenic Infections
I am writing in response to the Letter to the Editor by Dr. Saggese, regarding our paper titled "Overutilization of Computed Tomography for Odontogenic Infections". First, responding to your concern about our claim of no other published papers investigating computed tomography (CT) overuse for odontogenic infections, this was an accurate claim at the time of the article's initial submission.
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Former Norwich resident awarded additional $44 million in tobacco lawsuit - theday.com
U.S. District Judge Stefan R. Underhill has added $44 million in damages and interest to the nearly $8 million a jury awarded to former Norwich resident Barbara ...
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Steven Wayne McCracken | Obituaries - Richland Source
Steven Wayne McCracken, 66, of Galion, Ohio, passed away Friday morning, Dec. 14, 2018, surrounded by his family.
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Liz hits her target - Liverpool City Champion
It would be remiss not to use an archery term to describe Elizabeth Hole's magical 2018 – especially when it sums it up so perfectly.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A2B0kK
Is maxillomandibular advancement associated with comorbidity reduction in patients with obstructive sleep apnea?
In patients with documented obstructive sleep apnea (OSA) who experience reduction in AHI and self-reported symptoms after maxillomandibular advancement with genial tubercle advancement (MMA/GTA), is there also a change in the medical comorbidity profile a minimum of two years postoperatively? We are assessing for changes in: the quantity of medical diagnoses; the quantity of prescription medications; and the average weight and BMI.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Bpu5lt
Response to Letter to the Editor - RE: Overutilization of Computed Tomography for Odontogenic Infections
I am writing in response to the Letter to the Editor by Dr. Saggese, regarding our paper titled "Overutilization of Computed Tomography for Odontogenic Infections". First, responding to your concern about our claim of no other published papers investigating computed tomography (CT) overuse for odontogenic infections, this was an accurate claim at the time of the article's initial submission.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BvI210
The importance of recognizing an association between obstructive sleep apnea and post-traumatic stress disorder (Arthur Friedlander, et al), November 2018, V76, #11
To the Editor: - The recent article in Perspectives section of the journal on recognizing an association between obstructive sleep apnea and post-traumatic stress disorder by Friedlander et al (1) was a new and interesting view on the link between two, not traditionally associated, conditions. Authors indicated the still unknown nature of this association among a selected group of patients, especially military veterans. According to presented literature, possible connections between OSA and PTSD can be attributed to either typical for OSA fragmented sleep pattern with arousals coinciding with decreased airway muscle tone that is also common for disturbing dreams and unstable upper airways of PTSD, dysfunctional REM sleep mechanism and nightmare episodes demonstrated in both disorders, and other causes.
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Lupus tied to increased cancer risk - medwireNews
Meta-analysis: Lupus associated with an increased risk for 16 types of cancer.
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Innovation Pharmaceuticals Completes End-of-Phase 2 Meeting with FDA; Brilacidin Oral Rinse to Advance Into Phase 3 Clinical Trials for Prevention of Severe Oral Mucositis - Associated Press
BEVERLY, Mass., Dec. 17, 2018 (GLOBE NEWSWIRE) -- Innovation Pharmaceuticals (OTCQB:IPIX) ("the Company"), a clinical stage pharmaceutical company, ...
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