Purpose of review Anticoagulants in general, but especially the relatively new direct oral anticoagulants and platelet inhibitors, pose a great challenge for physicians in the hemorrhaging patient. The aim of the present review is to provide an overview on recent studies dealing with the reversal of anticoagulation in the hemorrhaging patient and to describe our therapeutic emergency strategy for those patients. Recent findings A specific antidote for dabigatran is already on the market and antidotes for the direct and indirect factor Xa inhibitors are in development. Moreover, bleeding under platelet inhibitors remains critical with very little evidence on effective reversal strategies. Summary To reverse anticoagulation in the hemorrhaging patient, specific antidotes should be the first option if available, followed by four-factor prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor seven as the emergency strategy. Fibrinogen concentrate, antifibrinolytics and oral charcoal, respectively, can be considered as an additional measure. Massive blood loss and thrombocytopenia should be treated independently according to the respective, local guidelines for (massive) transfusion of blood and blood products. Correspondence to Bettina Schenk, Department of General and Surgical Intensive Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. Tel: +0043 (0)512 504 80604; e-mail: Bettina.schenk@i-med.ac.at Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QZZg1r
Παρασκευή 28 Δεκεμβρίου 2018
Reversing anticoagulation in the hemorrhaging patient
Purpose of review Anticoagulants in general, but especially the relatively new direct oral anticoagulants and platelet inhibitors, pose a great challenge for physicians in the hemorrhaging patient. The aim of the present review is to provide an overview on recent studies dealing with the reversal of anticoagulation in the hemorrhaging patient and to describe our therapeutic emergency strategy for those patients. Recent findings A specific antidote for dabigatran is already on the market and antidotes for the direct and indirect factor Xa inhibitors are in development. Moreover, bleeding under platelet inhibitors remains critical with very little evidence on effective reversal strategies. Summary To reverse anticoagulation in the hemorrhaging patient, specific antidotes should be the first option if available, followed by four-factor prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor seven as the emergency strategy. Fibrinogen concentrate, antifibrinolytics and oral charcoal, respectively, can be considered as an additional measure. Massive blood loss and thrombocytopenia should be treated independently according to the respective, local guidelines for (massive) transfusion of blood and blood products. Correspondence to Bettina Schenk, Department of General and Surgical Intensive Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. Tel: +0043 (0)512 504 80604; e-mail: Bettina.schenk@i-med.ac.at Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QZZg1r
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QZZg1r
Staging and prognosis of oropharyngeal carcinoma according to the 8th Edition of the American Joint Committee on Cancer Staging Manual in human papillomavirus infection
Abstract
Purpose
The aim of this study was to evaluate the 8th edition of the American Joint Committee on Cancer Staging Manual: Head and Neck Section on oropharyngeal squamous cell cancer (OPSCC) and to clarify the relationship between p16 overexpression and the presence of human papillomavirus (HPV) DNA using fresh frozen samples.
Methods
Samples from 100 OPSCC patients were analyzed using polymerase chain reaction (PCR) and p16 immunohistochemistry.
Results
Five-year overall survival (OS) was 73.0%, 93.9%, and 62.2% in all, p16-positive (n = 34), and p16-negative (n = 66) cases, respectively. OS tended to be better aligned with stage in the 8th edition than in the 7th edition. The 5-year OS was 96.0% in never or light smokers (< 40 pack-years), and 87.5% in heavy smokers (≥ 40 pack-years) in the p16-positive group, respectively (p = 0.027). HPV infection was found in 100% of p16-positive and 21.2% of p16-negative cases. The p16-positive cases had higher viral load and integrated physical status than the p16-negative cases. Although 1 case with p16 overexpression showed no PCR amplification using consensus primers, PCR amplification was detected using HPV 16 E6-specific primers.
Conclusions
The 8th edition predicts OPSCC prognosis more accurately than the 7th edition and p16-overexpression is an excellent surrogate marker for detecting HPV infection. Although high-risk-type HPV infection was observed in p16-negative cases, it showed no significant effect in survival outcome.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESUefJ
Staging and prognosis of oropharyngeal carcinoma according to the 8th Edition of the American Joint Committee on Cancer Staging Manual in human papillomavirus infection
Abstract
Purpose
The aim of this study was to evaluate the 8th edition of the American Joint Committee on Cancer Staging Manual: Head and Neck Section on oropharyngeal squamous cell cancer (OPSCC) and to clarify the relationship between p16 overexpression and the presence of human papillomavirus (HPV) DNA using fresh frozen samples.
Methods
Samples from 100 OPSCC patients were analyzed using polymerase chain reaction (PCR) and p16 immunohistochemistry.
Results
Five-year overall survival (OS) was 73.0%, 93.9%, and 62.2% in all, p16-positive (n = 34), and p16-negative (n = 66) cases, respectively. OS tended to be better aligned with stage in the 8th edition than in the 7th edition. The 5-year OS was 96.0% in never or light smokers (< 40 pack-years), and 87.5% in heavy smokers (≥ 40 pack-years) in the p16-positive group, respectively (p = 0.027). HPV infection was found in 100% of p16-positive and 21.2% of p16-negative cases. The p16-positive cases had higher viral load and integrated physical status than the p16-negative cases. Although 1 case with p16 overexpression showed no PCR amplification using consensus primers, PCR amplification was detected using HPV 16 E6-specific primers.
Conclusions
The 8th edition predicts OPSCC prognosis more accurately than the 7th edition and p16-overexpression is an excellent surrogate marker for detecting HPV infection. Although high-risk-type HPV infection was observed in p16-negative cases, it showed no significant effect in survival outcome.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESUefJ
Role of Der p 1 –specific B cells in immune tolerance during 2 years of house dust mite–specific immunotherapy
Long-term follow-up of allergen-specific B cells in terms of immunoglobulin isotype expression, plasmablast differentiation, and regulatory B (Breg) cell development during allergen-specific immunotherapy (AIT) has not been reported. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2VcW8NY
IFN- λ1 enhances Staphylococcus aureus clearance in healthy nasal mucosa but not in nasal polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by TH2-skewed inflammation and increased colonization by Staphylococcus aureus. IFN- λ1 is known for its antiviral activity, but there is little information on its antibacterial role. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Q7rxxG
Role of Der p 1 –specific B cells in immune tolerance during 2 years of house dust mite–specific immunotherapy
Long-term follow-up of allergen-specific B cells in terms of immunoglobulin isotype expression, plasmablast differentiation, and regulatory B (Breg) cell development during allergen-specific immunotherapy (AIT) has not been reported. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2VcW8NY
IFN- λ1 enhances Staphylococcus aureus clearance in healthy nasal mucosa but not in nasal polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by TH2-skewed inflammation and increased colonization by Staphylococcus aureus. IFN- λ1 is known for its antiviral activity, but there is little information on its antibacterial role. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Q7rxxG
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CG4aYr
A Novel Thyroid Hormone Receptor Beta Mutation (G357R) in a Family with Resistance to Thyroid Hormone Beta: Extending the Borders of the “Hot” Region in the THRB Gene
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ThXlBF
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CG4aYr
A Novel Thyroid Hormone Receptor Beta Mutation (G357R) in a Family with Resistance to Thyroid Hormone Beta: Extending the Borders of the “Hot” Region in the THRB Gene
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ThXlBF
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EXlaev
A Novel Thyroid Hormone Receptor Beta Mutation (G357R) in a Family with Resistance to Thyroid Hormone Beta: Extending the Borders of the “Hot” Region in the THRB Gene
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EXB7BS
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EXlaev
A Novel Thyroid Hormone Receptor Beta Mutation (G357R) in a Family with Resistance to Thyroid Hormone Beta: Extending the Borders of the “Hot” Region in the THRB Gene
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EXB7BS
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CG4aYr
A Novel Thyroid Hormone Receptor Beta Mutation (G357R) in a Family with Resistance to Thyroid Hormone Beta: Extending the Borders of the “Hot” Region in the THRB Gene
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ThXlBF
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CG4aYr
A Novel Thyroid Hormone Receptor Beta Mutation (G357R) in a Family with Resistance to Thyroid Hormone Beta: Extending the Borders of the “Hot” Region in the THRB Gene
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ThXlBF
What You Clicked, Read and Shared This Year
Leader Live launched its new look this past spring. The goal involved creating a better display for all the online-exclusive content created to help audiologists and speech-language pathologists find out what's happening now in the world of communication sciences and disorders (CSD). You seem to like the new look and speed with which we can deliver the latest, because this year you read more posts from CSD pros, news stories about the professions, advocacy updates from ASHA, and other online-only articles than ever before. Here are the hot topics most viewed, shared and commented on from 2018. Is It 'Yanny' or 'Laurel'? The Internet Wants Answers As the Internet debated this audio chameleon—dividing friends, families and co-workers world...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EUA98X
What You Clicked, Read and Shared This Year
Leader Live launched its new look this past spring. The goal involved creating a better display for all the online-exclusive content created to help audiologists and speech-language pathologists find out what's happening now in the world of communication sciences and disorders (CSD). You seem to like the new look and speed with which we can deliver the latest, because this year you read more posts from CSD pros, news stories about the professions, advocacy updates from ASHA, and other online-only articles than ever before. Here are the hot topics most viewed, shared and commented on from 2018. Is It 'Yanny' or 'Laurel'? The Internet Wants Answers As the Internet debated this audio chameleon—dividing friends, families and co-workers world...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EUA98X
Daily Aspirin May Reduce COPD Exacerbations
(MedPage Today) -- Treatment also appeared to improve shortness of breath (Source: MedPage Today Allergy)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QXwWwy
What You Clicked, Read and Shared This Year
Leader Live launched its new look this past spring. The goal involved creating a better display for all the online-exclusive content created to help audiologists and speech-language pathologists find out what's happening now in the world of communication sciences and disorders (CSD). You seem to like the new look and speed with which we can deliver the latest, because this year you read more posts from CSD pros, news stories about the professions, advocacy updates from ASHA, and other online-only articles than ever before. Here are the hot topics most viewed, shared and commented on from 2018. Is It 'Yanny' or 'Laurel'? The Internet Wants Answers As the Internet debated this audio chameleon—dividing friends, families and co-workers world...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EUA98X
Surgically assisted rapid maxillary expansion with bone-borne versus tooth-borne distraction appliances—a systematic review
The objective was to test the hypothesis of no difference in skeletal and dental arch expansion and relapse after surgically assisted rapid maxillary expansion with a bone-borne compared with a tooth-borne appliance. The PubMed, Embase (Ovid), Cochrane Library, and Google Scholar databases were searched in combination with a hand-search of relevant journals up until December 2017. No language restriction was applied. Two short-term randomized controlled trials with a low risk of bias fulfilled the inclusion criteria.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Viqn6m
Cranial nerve injuries in Le Fort I osteotomy: a systematic review
The aim of this systematic review was to describe the anatomical and surgical factors related to cranial nerve injuries in Le Fort I osteotomy. The protocol of this systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO). Two independent reviewers performed an unrestricted electronic database search in the MEDLINE/PubMed, LILACS, Scopus, Web of Science, and Cochrane databases up to and including August 2018. Thirty-two articles were selected for data extraction and synthesis: 30 studies were identified in the main search and two by a manual search.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Q8GRtK
Daily Aspirin May Reduce COPD Exacerbations
(MedPage Today) -- Treatment also appeared to improve shortness of breath (Source: MedPage Today Allergy)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QXwWwy
What You Clicked, Read and Shared This Year
Leader Live launched its new look this past spring. The goal involved creating a better display for all the online-exclusive content created to help audiologists and speech-language pathologists find out what's happening now in the world of communication sciences and disorders (CSD). You seem to like the new look and speed with which we can deliver the latest, because this year you read more posts from CSD pros, news stories about the professions, advocacy updates from ASHA, and other online-only articles than ever before. Here are the hot topics most viewed, shared and commented on from 2018. Is It 'Yanny' or 'Laurel'? The Internet Wants Answers As the Internet debated this audio chameleon—dividing friends, families and co-workers world...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EUA98X
Surgically assisted rapid maxillary expansion with bone-borne versus tooth-borne distraction appliances—a systematic review
The objective was to test the hypothesis of no difference in skeletal and dental arch expansion and relapse after surgically assisted rapid maxillary expansion with a bone-borne compared with a tooth-borne appliance. The PubMed, Embase (Ovid), Cochrane Library, and Google Scholar databases were searched in combination with a hand-search of relevant journals up until December 2017. No language restriction was applied. Two short-term randomized controlled trials with a low risk of bias fulfilled the inclusion criteria.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Viqn6m
Cranial nerve injuries in Le Fort I osteotomy: a systematic review
The aim of this systematic review was to describe the anatomical and surgical factors related to cranial nerve injuries in Le Fort I osteotomy. The protocol of this systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO). Two independent reviewers performed an unrestricted electronic database search in the MEDLINE/PubMed, LILACS, Scopus, Web of Science, and Cochrane databases up to and including August 2018. Thirty-two articles were selected for data extraction and synthesis: 30 studies were identified in the main search and two by a manual search.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Q8GRtK
Daily Aspirin May Reduce COPD Exacerbations
(MedPage Today) -- Treatment also appeared to improve shortness of breath (Source: MedPage Today Allergy)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QXwWwy
Daily Aspirin May Reduce COPD Exacerbations
(MedPage Today) -- Treatment also appeared to improve shortness of breath (Source: MedPage Today Allergy)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QXwWwy
What You Clicked, Read and Shared This Year
Leader Live launched its new look this past spring. The goal involved creating a better display for all the online-exclusive content created to help audiologists and speech-language pathologists find out what's happening now in the world of communication sciences and disorders (CSD). You seem to like the new look and speed with which we can deliver the latest, because this year you read more posts from CSD pros, news stories about the professions, advocacy updates from ASHA, and other online-only articles than ever before. Here are the hot topics most viewed, shared and commented on from 2018. Is It 'Yanny' or 'Laurel'? The Internet Wants Answers As the Internet debated this audio chameleon—dividing friends, families and co-workers world...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EUA98X
What You Clicked, Read and Shared This Year
Leader Live launched its new look this past spring. The goal involved creating a better display for all the online-exclusive content created to help audiologists and speech-language pathologists find out what's happening now in the world of communication sciences and disorders (CSD). You seem to like the new look and speed with which we can deliver the latest, because this year you read more posts from CSD pros, news stories about the professions, advocacy updates from ASHA, and other online-only articles than ever before. Here are the hot topics most viewed, shared and commented on from 2018. Is It 'Yanny' or 'Laurel'? The Internet Wants Answers As the Internet debated this audio chameleon—dividing friends, families and co-workers world...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EUA98X
Free Flap Head and Neck Reconstruction with an Emphasis on Postoperative Care
Facial plast Surg 2018; 34: 597-604
DOI: 10.1055/s-0038-1676076
Microsurgical free tissue transfer represents the mainstay of care in both ablative locoregional management and the simultaneous reconstruction of a defect. Advances in microsurgical techniques have helped balance the restoration of both form and function—decreasing the significant morbidity once associated with large ablative, traumatic, or congenital defects—while providing immediate reconstruction enabling early aesthetic and functional rehabilitation. There are a multitude of perioperative measures and considerations that aim to maximize the success of free tissue transfer. These include nutritional support, tight glycemic control, acknowledgment of psychological and psychiatric factors, intraoperative surgical technique, and close postoperative monitoring of the patients' hemodynamic physiology. While the success rates of free tissue transfer in experienced hands are comparable to alternative options, the consequences of flap failure are catastrophic—with the potential for significant patient morbidity, prolonged hospital stay (and associated increased financial implications), and increasingly limited options for further reconstruction. Success is entirely dependent on a continuous arterial inflow and venous outflow until neovascularization occurs. Flap failure is multifactorial and represents a dynamic process from the potentially reversible failing flap to the necrotic irreversibly failed flap—necessitating debridement, prolonged wound care, and ultimately decisions concerned with future reconstruction. The overriding goal of free flap monitoring is therefore the detection of microvascular complications prior to permanent injury occurring—identifying and intervening within that critical period between the failing flap and the failed flap—maximizing the potential for salvage. With continued technique refinement, microvascular free flap reconstruction offers patients the chance for both reliable functional and aesthetic restoration in the face of significant ablative defects. The caveat to this optimism is the requirement for considered perioperative care and the optimization of those factors that may offer the difference between success and failure.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AgVLsQ
A Giant Cutaneous Horn on the Cheek
Facial plast Surg 2018; 34: 663-664
DOI: 10.1055/s-0038-1675635
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw9aod
Postoperative Care in Aesthetic Rhinoplasty Patients
Facial plast Surg 2018; 34: 553-560
DOI: 10.1055/s-0038-1676379
After rhinoplasty, during the first 24 hours, the patients should be closely monitored for pain and discomfort, nausea and vomiting, and cool compresses must be applied regularly to decrease edema and ecchymosis. In the early postoperative period of the first month, the sutures, cast, and splints are usually removed during the first week. Then the patient is followed-up at 1, 3, 6, and 12-month intervals routinely to observe healing. In the meantime, any kind of intranasal and extranasal complications should be noted. The outcome measures such as ROE, NOSE, or SCHNOS should be used 3 to 6 months after surgery. If the patient is closely followed-up, then any unwanted complication or dissatisfaction can be solved after 6 to 12 months.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AmlL63
Postoperative Care in Facial Implants
Facial plast Surg 2018; 34: 612-623
DOI: 10.1055/s-0038-1676463
Facial augmentation is a growing field, secondary to the appreciation of the changes seen in the facial skeleton with aging and the growing acceptance/popularity of facial fat grafting and facial fillers. In addition, it plays a significant role in patients with congenital facial deficiencies as well as those interested in facial feminization/masculinization surgery. Several facial implants are discussed in this article including classic facial implants such as malar, submalar, chin, and prejowl implants as well as newer facial implants such as mandible, temporal, forehead, and skull implants. Special care is given to the postoperative care of these implants. Custom-made implants with three-dimensional computed tomography reconstruction are also discussed
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SlLcM9
Face and Neck Lift—Postoperative Care
Facial plast Surg 2018; 34: 561-569
DOI: 10.1055/s-0038-1676380
Primary aim of the article is a discussion of the postoperative care after face and neck lift. A brief history of face and neck lift along with different techniques are described. Importance of preoperative assessment is stressed.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AlbTJX
General Precautions and Safety Aspects of Facial Laser Treatment
Facial plast Surg 2018; 34: 588-596
DOI: 10.1055/s-0038-1676284
The current overview of laser radiation therapy options and the legal aspects of the head and neck region provides insight into the available laser hardware, discusses the indications and treatment options and risks, as well as the necessary precautions to be taken when operating a laser device. Further handling recommendations and requirements for the laser devices are drawn and the question of transferring tasks to nonmedical personnel is discussed. The reader should get an idea about the benefits and risks of using lasers in treating patients and be able to set the precise indication on the background of possibilities, adverse effects, and legal aspects.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw95AV
Postoperative Care of the Facial Plastic Surgery Patient—Forehead and Blepharoplasty
Facial plast Surg 2018; 34: 570-578
DOI: 10.1055/s-0038-1676354
In any kind of surgery, postoperative care is essential for a good result, but especially when the matter at stake is facial plastic surgery. Despite having performed a perfect surgery, with the least amount of damage to the soft tissues and osteocartilaginous structures, minimal bleeding, and in terms of the surgical time, without adequate postoperative care our results can be affected considerably in the short and long run. Therefore, we must have very clear guidelines regarding postoperative care and the duties of our patients, which should be emphasized during the informed consent of the intervention. It is also essential to comment on the warning signs of postoperative complications, which need to be detected and treated in time to achieve the expected post-surgery results. Before being discharged from the hospital, the patient again receives the postoperative instructions, as well as receiving a paper copy to avoid any possible misunderstandings. In this article, we will detail the postoperative care and complications of brow lift and upper and lower blepharoplasty.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AjyPtc
Postoperative Management of Cleft Lip and Palate Surgery
Facial plast Surg 2018; 34: 605-611
DOI: 10.1055/s-0038-1676381
Cleft lip and palatal clefts are one of the most common birth defects with a global incidence of 1 in 700 live births. The majority of these orofacial clefts are nonsyndromic. However, a general screening for syndromes and other organ anomalies should always be performed as their association with orofacial clefts cannot be overlooked. With the recent progress in the knowledge of cleft repair, the procedures to correct cleft lip and palate though complex, have been simplified to allow improvisation in outcome and to achieve even better finesse of surgical result. The procedural complications and the pursuit of having near perfect esthetics and functionality, make this deformity a recipient of multiple procedures. This ensures that the patient is under the care of the treating surgeon for long term and allows the surgeon to follow-up on the result, not only to provide care but also to intercept any deviation in the desired outcome. Postoperative care of cleft lip and palate surgery is largely underdiscussed and a set of fixed guidelines will help the treating surgeon to provide the most comprehensive care to the cleft patients. The authors review the practices followed at their hospitals—a high volume cleft and craniofacial care center, a tertiary care multispeciality teaching hospital, and a community teaching and training hospital. The commonly followed practices with suitable evidence in postoperative care of these patients are enlisted here.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw9y69
Perioperative Care Considerations and Management of Complications Involving Surgical and Technology Procedures
Facial plast Surg 2018; 34: 579-587
DOI: 10.1055/s-0038-1676119
Technology impacts the lives of everyone nowadays and has had perhaps a greater impact on the lives of facial plastic surgeons and the patients they seek to help with both surgery and procedures. This article will discuss modern technology's impact on intervening in the aging process including technology used for facial and skin rejuvenation and reconstruction concentrating on the techniques and care to minimize complications as well as dealing with complication from the treatments.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AuPr1d
The Evidence for Adjunctive Facelift Procedures
Facial plast Surg 2018; 34: 624-630
DOI: 10.1055/s-0038-1675750
Facelift surgery is a popular treatment but exhibits high variation among practitioners in terms of both core technique and adjunctive measures. This review identified significant evidence addressing the role of pre-infiltration, drains, fat grafting, fibrin tissue adhesives, hilotherapy, and other miscellaneous adjuncts. Based on the authors' assessment of the current literature, there is reasonable supportive evidence for pre-infiltration, fat grafting and laser skin resurfacing, which appear to be safe and effective in appropriately selected patients. Drain use is not mandatory but may confer some benefit. Conversely the evidence for the use of fibrin tissue adhesives and hilotherapy is not compelling.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw8YW1
Postoperative Care in Facial Plastic Surgery
Facial plast Surg 2018; 34: 551-552
DOI: 10.1055/s-0038-1676526
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ame0Nu
Free Flap Head and Neck Reconstruction with an Emphasis on Postoperative Care
Facial plast Surg 2018; 34: 597-604
DOI: 10.1055/s-0038-1676076
Microsurgical free tissue transfer represents the mainstay of care in both ablative locoregional management and the simultaneous reconstruction of a defect. Advances in microsurgical techniques have helped balance the restoration of both form and function—decreasing the significant morbidity once associated with large ablative, traumatic, or congenital defects—while providing immediate reconstruction enabling early aesthetic and functional rehabilitation. There are a multitude of perioperative measures and considerations that aim to maximize the success of free tissue transfer. These include nutritional support, tight glycemic control, acknowledgment of psychological and psychiatric factors, intraoperative surgical technique, and close postoperative monitoring of the patients' hemodynamic physiology. While the success rates of free tissue transfer in experienced hands are comparable to alternative options, the consequences of flap failure are catastrophic—with the potential for significant patient morbidity, prolonged hospital stay (and associated increased financial implications), and increasingly limited options for further reconstruction. Success is entirely dependent on a continuous arterial inflow and venous outflow until neovascularization occurs. Flap failure is multifactorial and represents a dynamic process from the potentially reversible failing flap to the necrotic irreversibly failed flap—necessitating debridement, prolonged wound care, and ultimately decisions concerned with future reconstruction. The overriding goal of free flap monitoring is therefore the detection of microvascular complications prior to permanent injury occurring—identifying and intervening within that critical period between the failing flap and the failed flap—maximizing the potential for salvage. With continued technique refinement, microvascular free flap reconstruction offers patients the chance for both reliable functional and aesthetic restoration in the face of significant ablative defects. The caveat to this optimism is the requirement for considered perioperative care and the optimization of those factors that may offer the difference between success and failure.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AgVLsQ
A Giant Cutaneous Horn on the Cheek
Facial plast Surg 2018; 34: 663-664
DOI: 10.1055/s-0038-1675635
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw9aod
Postoperative Care in Aesthetic Rhinoplasty Patients
Facial plast Surg 2018; 34: 553-560
DOI: 10.1055/s-0038-1676379
After rhinoplasty, during the first 24 hours, the patients should be closely monitored for pain and discomfort, nausea and vomiting, and cool compresses must be applied regularly to decrease edema and ecchymosis. In the early postoperative period of the first month, the sutures, cast, and splints are usually removed during the first week. Then the patient is followed-up at 1, 3, 6, and 12-month intervals routinely to observe healing. In the meantime, any kind of intranasal and extranasal complications should be noted. The outcome measures such as ROE, NOSE, or SCHNOS should be used 3 to 6 months after surgery. If the patient is closely followed-up, then any unwanted complication or dissatisfaction can be solved after 6 to 12 months.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AmlL63
Postoperative Care in Facial Implants
Facial plast Surg 2018; 34: 612-623
DOI: 10.1055/s-0038-1676463
Facial augmentation is a growing field, secondary to the appreciation of the changes seen in the facial skeleton with aging and the growing acceptance/popularity of facial fat grafting and facial fillers. In addition, it plays a significant role in patients with congenital facial deficiencies as well as those interested in facial feminization/masculinization surgery. Several facial implants are discussed in this article including classic facial implants such as malar, submalar, chin, and prejowl implants as well as newer facial implants such as mandible, temporal, forehead, and skull implants. Special care is given to the postoperative care of these implants. Custom-made implants with three-dimensional computed tomography reconstruction are also discussed
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SlLcM9
Face and Neck Lift—Postoperative Care
Facial plast Surg 2018; 34: 561-569
DOI: 10.1055/s-0038-1676380
Primary aim of the article is a discussion of the postoperative care after face and neck lift. A brief history of face and neck lift along with different techniques are described. Importance of preoperative assessment is stressed.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AlbTJX
General Precautions and Safety Aspects of Facial Laser Treatment
Facial plast Surg 2018; 34: 588-596
DOI: 10.1055/s-0038-1676284
The current overview of laser radiation therapy options and the legal aspects of the head and neck region provides insight into the available laser hardware, discusses the indications and treatment options and risks, as well as the necessary precautions to be taken when operating a laser device. Further handling recommendations and requirements for the laser devices are drawn and the question of transferring tasks to nonmedical personnel is discussed. The reader should get an idea about the benefits and risks of using lasers in treating patients and be able to set the precise indication on the background of possibilities, adverse effects, and legal aspects.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw95AV
Postoperative Care of the Facial Plastic Surgery Patient—Forehead and Blepharoplasty
Facial plast Surg 2018; 34: 570-578
DOI: 10.1055/s-0038-1676354
In any kind of surgery, postoperative care is essential for a good result, but especially when the matter at stake is facial plastic surgery. Despite having performed a perfect surgery, with the least amount of damage to the soft tissues and osteocartilaginous structures, minimal bleeding, and in terms of the surgical time, without adequate postoperative care our results can be affected considerably in the short and long run. Therefore, we must have very clear guidelines regarding postoperative care and the duties of our patients, which should be emphasized during the informed consent of the intervention. It is also essential to comment on the warning signs of postoperative complications, which need to be detected and treated in time to achieve the expected post-surgery results. Before being discharged from the hospital, the patient again receives the postoperative instructions, as well as receiving a paper copy to avoid any possible misunderstandings. In this article, we will detail the postoperative care and complications of brow lift and upper and lower blepharoplasty.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AjyPtc
Postoperative Management of Cleft Lip and Palate Surgery
Facial plast Surg 2018; 34: 605-611
DOI: 10.1055/s-0038-1676381
Cleft lip and palatal clefts are one of the most common birth defects with a global incidence of 1 in 700 live births. The majority of these orofacial clefts are nonsyndromic. However, a general screening for syndromes and other organ anomalies should always be performed as their association with orofacial clefts cannot be overlooked. With the recent progress in the knowledge of cleft repair, the procedures to correct cleft lip and palate though complex, have been simplified to allow improvisation in outcome and to achieve even better finesse of surgical result. The procedural complications and the pursuit of having near perfect esthetics and functionality, make this deformity a recipient of multiple procedures. This ensures that the patient is under the care of the treating surgeon for long term and allows the surgeon to follow-up on the result, not only to provide care but also to intercept any deviation in the desired outcome. Postoperative care of cleft lip and palate surgery is largely underdiscussed and a set of fixed guidelines will help the treating surgeon to provide the most comprehensive care to the cleft patients. The authors review the practices followed at their hospitals—a high volume cleft and craniofacial care center, a tertiary care multispeciality teaching hospital, and a community teaching and training hospital. The commonly followed practices with suitable evidence in postoperative care of these patients are enlisted here.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw9y69
Perioperative Care Considerations and Management of Complications Involving Surgical and Technology Procedures
Facial plast Surg 2018; 34: 579-587
DOI: 10.1055/s-0038-1676119
Technology impacts the lives of everyone nowadays and has had perhaps a greater impact on the lives of facial plastic surgeons and the patients they seek to help with both surgery and procedures. This article will discuss modern technology's impact on intervening in the aging process including technology used for facial and skin rejuvenation and reconstruction concentrating on the techniques and care to minimize complications as well as dealing with complication from the treatments.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AuPr1d
The Evidence for Adjunctive Facelift Procedures
Facial plast Surg 2018; 34: 624-630
DOI: 10.1055/s-0038-1675750
Facelift surgery is a popular treatment but exhibits high variation among practitioners in terms of both core technique and adjunctive measures. This review identified significant evidence addressing the role of pre-infiltration, drains, fat grafting, fibrin tissue adhesives, hilotherapy, and other miscellaneous adjuncts. Based on the authors' assessment of the current literature, there is reasonable supportive evidence for pre-infiltration, fat grafting and laser skin resurfacing, which appear to be safe and effective in appropriately selected patients. Drain use is not mandatory but may confer some benefit. Conversely the evidence for the use of fibrin tissue adhesives and hilotherapy is not compelling.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw8YW1
Postoperative Care in Facial Plastic Surgery
Facial plast Surg 2018; 34: 551-552
DOI: 10.1055/s-0038-1676526
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ame0Nu
Neutrophil activation in occupational asthma
Purpose of review The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitates a better understanding, accurate diagnosis, and proper management of asthmatic reactions provoked at the workplace. Recent findings Increased recruitment and infiltration of neutrophils are found in patients with occupational asthma. Activated neutrophils release several mediators including pro-inflammatory cytokines and extracellular traps, leading to stimulation of airway epithelium and other inflammatory cells. Summary New insights into neutrophils in the pathogenesis of occupational asthma may provide a novel approach to the individual patient with occupational asthma. Correspondence to Hae-Sim Park, MD, PhD, Department of Allergy and Clinical Immunology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, Korea. Tel: +82 31 219 5196; fax: +82 31 219 5154; e-mail: hspark@ajou.ac.kr Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RjRHlo
Use of population data for assessing trends in work-related asthma mortality
Purpose of review Work-related asthma has been associated with poorer asthma control and frequent unscheduled healthcare visits, and can be fatal. Case reports of work-related asthma deaths are rare, but can initiate efforts to prevent additional cases. We reviewed relevant literature and data sources to evaluate whether analyzing mortality data at the population level can help identify potential sources of exposures that contribute to work-related asthma. Recent findings A limited number of population-based studies have addressed work-related asthma mortality. Data on asthma mortality are derived from death certificates using the International Classification of Diseases (ICD) as a standard for coding cause. However, no discrete code for work-related asthma is available. Analysis of asthma mortality relative to industries and occupations appears to identify high-risk jobs that were not identified by analyzing asthma morbidity data. Summary Beyond recognized work-related asthma deaths, it is possible that occupational exposures have contributed to other asthma deaths that have gone unnoticed and could potentially be identified by the analysis of mortality data at the population level. Such analyses in the United States appear to assist in recognizing high-risk occupations and industries. Additional analyses would be possible if a work-related asthma ICD code were available. Correspondence to Jacek M. Mazurek, MD, MS, PhD, Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), Mailstop HG908, 1095 Willowdale Road, Morgantown, WV 26505, USA. Tel: +1 304 285 5983; e-mail: jmazurek1@cdc.gov Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GI3SEx
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GI3SEx
The impact of exercise on asthma
Purpose of review Asthma is one of the most common chronic diseases in children and adults in developed countries around the world. Despite international treatment guidelines, poor asthma control remains a frequent problem leading to missed school and work, and emergency room visits and hospitalizations. Many patients with asthma report exercise as a trigger for their asthma, which likely leads to exercise avoidance as a means to control symptoms. Evolving research has suggested that routine exercise may actually help improve some aspects of asthma control. This review discusses the recent research addressing how routine exercise affects important asthma-related outcomes including symptoms, lung function and quality of life. Recent findings Several systematic reviews and meta-analyses have been conducted in recent years, which strongly support the safety of routine exercise in children and adults with asthma. Exercise appears to favor improvements in aerobic fitness, asthma symptoms and quality of life, but results so far are less consistent in demonstrating improvements to lung function and airway hyperresponsiveness. Summary In addition to routine management guidelines, clinicians should recommend for their patients with asthma routine exercise for its general health benefits and likely improvement in asthma symptoms and quality of life. Correspondence to Jason E. Lang, MD, MPH, Division of Allergy/Immunology and Pulmonary Medicine, Duke Children's Hospital and Health Center, MSRB-1 203 Research Drive Rm 127, Durham, North Carolina, USA. Tel: +1 919 684 8657; fax: +1 919 684 2292; e-mail: jason.lang@duke.edu Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RjRtuy
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RjRtuy
Neutrophil activation in occupational asthma
Purpose of review The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitates a better understanding, accurate diagnosis, and proper management of asthmatic reactions provoked at the workplace. Recent findings Increased recruitment and infiltration of neutrophils are found in patients with occupational asthma. Activated neutrophils release several mediators including pro-inflammatory cytokines and extracellular traps, leading to stimulation of airway epithelium and other inflammatory cells. Summary New insights into neutrophils in the pathogenesis of occupational asthma may provide a novel approach to the individual patient with occupational asthma. Correspondence to Hae-Sim Park, MD, PhD, Department of Allergy and Clinical Immunology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, Korea. Tel: +82 31 219 5196; fax: +82 31 219 5154; e-mail: hspark@ajou.ac.kr Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RjRHlo
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RjRHlo
Use of population data for assessing trends in work-related asthma mortality
Purpose of review Work-related asthma has been associated with poorer asthma control and frequent unscheduled healthcare visits, and can be fatal. Case reports of work-related asthma deaths are rare, but can initiate efforts to prevent additional cases. We reviewed relevant literature and data sources to evaluate whether analyzing mortality data at the population level can help identify potential sources of exposures that contribute to work-related asthma. Recent findings A limited number of population-based studies have addressed work-related asthma mortality. Data on asthma mortality are derived from death certificates using the International Classification of Diseases (ICD) as a standard for coding cause. However, no discrete code for work-related asthma is available. Analysis of asthma mortality relative to industries and occupations appears to identify high-risk jobs that were not identified by analyzing asthma morbidity data. Summary Beyond recognized work-related asthma deaths, it is possible that occupational exposures have contributed to other asthma deaths that have gone unnoticed and could potentially be identified by the analysis of mortality data at the population level. Such analyses in the United States appear to assist in recognizing high-risk occupations and industries. Additional analyses would be possible if a work-related asthma ICD code were available. Correspondence to Jacek M. Mazurek, MD, MS, PhD, Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), Mailstop HG908, 1095 Willowdale Road, Morgantown, WV 26505, USA. Tel: +1 304 285 5983; e-mail: jmazurek1@cdc.gov Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GI3SEx
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GI3SEx
The impact of exercise on asthma
Purpose of review Asthma is one of the most common chronic diseases in children and adults in developed countries around the world. Despite international treatment guidelines, poor asthma control remains a frequent problem leading to missed school and work, and emergency room visits and hospitalizations. Many patients with asthma report exercise as a trigger for their asthma, which likely leads to exercise avoidance as a means to control symptoms. Evolving research has suggested that routine exercise may actually help improve some aspects of asthma control. This review discusses the recent research addressing how routine exercise affects important asthma-related outcomes including symptoms, lung function and quality of life. Recent findings Several systematic reviews and meta-analyses have been conducted in recent years, which strongly support the safety of routine exercise in children and adults with asthma. Exercise appears to favor improvements in aerobic fitness, asthma symptoms and quality of life, but results so far are less consistent in demonstrating improvements to lung function and airway hyperresponsiveness. Summary In addition to routine management guidelines, clinicians should recommend for their patients with asthma routine exercise for its general health benefits and likely improvement in asthma symptoms and quality of life. Correspondence to Jason E. Lang, MD, MPH, Division of Allergy/Immunology and Pulmonary Medicine, Duke Children's Hospital and Health Center, MSRB-1 203 Research Drive Rm 127, Durham, North Carolina, USA. Tel: +1 919 684 8657; fax: +1 919 684 2292; e-mail: jason.lang@duke.edu Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RjRtuy
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RjRtuy
NIDCD Clinical Research Center Grant (P50 Clinical Trial Optional)
Funding Opportunity PAR-19-137 from the NIH Guide for Grants and Contracts. The National Institute on Deafness and Other Communication Disorders (NIDCD) invites applications for Clinical Research Center Grants designed to advance the diagnosis, prevention, treatment, and amelioration of human communication disorders. For this announcement, Clinical Research is defined as research involving individuals with communication disorders or data/tissues from individuals with a communication disorder. Examples of such research include but are not limited to, studies of the prevention, pathogenesis, pathophysiology, diagnosis, treatment, management or epidemiology of a disease or disorder of hearing, balance, smell, taste, voice, speech, or language. Applications may propose a clinical trial but ar...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESYQDr
NIDCD Clinical Research Center Grant (P50 Clinical Trial Optional)
Funding Opportunity PAR-19-137 from the NIH Guide for Grants and Contracts. The National Institute on Deafness and Other Communication Disorders (NIDCD) invites applications for Clinical Research Center Grants designed to advance the diagnosis, prevention, treatment, and amelioration of human communication disorders. For this announcement, Clinical Research is defined as research involving individuals with communication disorders or data/tissues from individuals with a communication disorder. Examples of such research include but are not limited to, studies of the prevention, pathogenesis, pathophysiology, diagnosis, treatment, management or epidemiology of a disease or disorder of hearing, balance, smell, taste, voice, speech, or language. Applications may propose a clinical trial but ar...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Clinical Thyroidology®High-Impact Articles
FREE ACCESS through January 11, 2019
Read Now:
Levothyroxine Replacement for Primary Hypothyroidism Can Be Given Between Meals with Similar Effectiveness at Various Times of the Day
Charles H. Emerson
Most "Recurrences" of Thyroid Cancer Represent Persistent Rather Than Recurrent Disease
Martin Biermann, Katrin Brauckhoff
Surgery for Hyperthyroidism Lowers Cardiovascular Mortality Compared with Radioactive Iodine
Andrew J. Day, Michael W. Yeh, Masha J. Livhits
No Benefit of Levothyroxine Among Pregnant Hypothyroid and/or Hypothyroxinemic Women on Offspring IQ at Age 9 years
Angela M. Leung
Current ATA Thyroid Cancer Guidelines Are Poor Predictors of the Extent of Thyroidectomy
Tracy S. Wang
Levothyroxine Treatment Does Not Reduce Risk for Premature Delivery Among TPO-Negative Pregnant Women with a TSH of 2.5 to 10.0 mIU/L
Elizabeth N. Pearce
Methimazole Has a Dose-Dependent Association With Congenital Malformations, but Switching to PTU in the First Trimester Seems Too Late
Tim I.M. Korevaar
The post Clinical Thyroidology<sup>®</sup>High-Impact Articles appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AiF948
Clinical Thyroidology®High-Impact Articles
FREE ACCESS through January 11, 2019
Read Now:
Levothyroxine Replacement for Primary Hypothyroidism Can Be Given Between Meals with Similar Effectiveness at Various Times of the Day
Charles H. Emerson
Most "Recurrences" of Thyroid Cancer Represent Persistent Rather Than Recurrent Disease
Martin Biermann, Katrin Brauckhoff
Surgery for Hyperthyroidism Lowers Cardiovascular Mortality Compared with Radioactive Iodine
Andrew J. Day, Michael W. Yeh, Masha J. Livhits
No Benefit of Levothyroxine Among Pregnant Hypothyroid and/or Hypothyroxinemic Women on Offspring IQ at Age 9 years
Angela M. Leung
Current ATA Thyroid Cancer Guidelines Are Poor Predictors of the Extent of Thyroidectomy
Tracy S. Wang
Levothyroxine Treatment Does Not Reduce Risk for Premature Delivery Among TPO-Negative Pregnant Women with a TSH of 2.5 to 10.0 mIU/L
Elizabeth N. Pearce
Methimazole Has a Dose-Dependent Association With Congenital Malformations, but Switching to PTU in the First Trimester Seems Too Late
Tim I.M. Korevaar
The post Clinical Thyroidology<sup>®</sup>High-Impact Articles appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AiF948
Clinical Thyroidology®High-Impact Articles
FREE ACCESS through January 11, 2019
Read Now:
Levothyroxine Replacement for Primary Hypothyroidism Can Be Given Between Meals with Similar Effectiveness at Various Times of the Day
Charles H. Emerson
Most "Recurrences" of Thyroid Cancer Represent Persistent Rather Than Recurrent Disease
Martin Biermann, Katrin Brauckhoff
Surgery for Hyperthyroidism Lowers Cardiovascular Mortality Compared with Radioactive Iodine
Andrew J. Day, Michael W. Yeh, Masha J. Livhits
No Benefit of Levothyroxine Among Pregnant Hypothyroid and/or Hypothyroxinemic Women on Offspring IQ at Age 9 years
Angela M. Leung
Current ATA Thyroid Cancer Guidelines Are Poor Predictors of the Extent of Thyroidectomy
Tracy S. Wang
Levothyroxine Treatment Does Not Reduce Risk for Premature Delivery Among TPO-Negative Pregnant Women with a TSH of 2.5 to 10.0 mIU/L
Elizabeth N. Pearce
Methimazole Has a Dose-Dependent Association With Congenital Malformations, but Switching to PTU in the First Trimester Seems Too Late
Tim I.M. Korevaar
The post Clinical Thyroidology<sup>®</sup>High-Impact Articles appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AiF948
Clinical Thyroidology®High-Impact Articles
FREE ACCESS through January 11, 2019
Read Now:
Levothyroxine Replacement for Primary Hypothyroidism Can Be Given Between Meals with Similar Effectiveness at Various Times of the Day
Charles H. Emerson
Most "Recurrences" of Thyroid Cancer Represent Persistent Rather Than Recurrent Disease
Martin Biermann, Katrin Brauckhoff
Surgery for Hyperthyroidism Lowers Cardiovascular Mortality Compared with Radioactive Iodine
Andrew J. Day, Michael W. Yeh, Masha J. Livhits
No Benefit of Levothyroxine Among Pregnant Hypothyroid and/or Hypothyroxinemic Women on Offspring IQ at Age 9 years
Angela M. Leung
Current ATA Thyroid Cancer Guidelines Are Poor Predictors of the Extent of Thyroidectomy
Tracy S. Wang
Levothyroxine Treatment Does Not Reduce Risk for Premature Delivery Among TPO-Negative Pregnant Women with a TSH of 2.5 to 10.0 mIU/L
Elizabeth N. Pearce
Methimazole Has a Dose-Dependent Association With Congenital Malformations, but Switching to PTU in the First Trimester Seems Too Late
Tim I.M. Korevaar
The post Clinical Thyroidology<sup>®</sup>High-Impact Articles appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AiF948
Restoring Skeletal Marker Points for Severe Maxillary and Mandibular Jaw Defects Using a Linear Regression Approach
For severe mandibular or maxillary defects across the midline, doctors often lack data on the shape of the jaws when designing virtual surgery. This study sought to repair the personalized 3-dimensional shape of the jaw, particularly when the jaw is severely damaged.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EQUBYc
Rhinolith: Examining the clinical, radiological and surgical features of 23 cases
Rhinolith is a hard nasal mass formed in time by the mineral salts around an endogenous or exogenous-originating nidus. Rhinolith, which is seen rarely, has been reported in the literature as case reports. In this study, we are presenting the demographic and clinical features together with accompanying sinonasal pathologies of 23 rhinolith cases.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EWwbxn
Otitis media with effusion in Nigerian children with cleft palate: incidence and risk factors
Otitis media with effusion is common in children with cleft palate, and the aim of this study was to find out its incidence and risk factors in Nigerians. We prospectively studied 84 patients (42 with cleft palate and 42 control subjects); 27 were male and 15 female, who were age and sex matched with control subjects. The extent and size of the clefts were measured using a dental cast and Vernier calipers, and the otitis media was diagnosed with otoscopy and tympanometry. The mean (SD) age of the groups was 11 (7) months (range 1–33).
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ERRjnv
Extensive bony metastases from facial metatypical basal cell carcinoma: a case report
Metastatic basal cell carcinoma (BCC) is rare. We treated a 44-year-old woman with an extended facial metatypical BCC in whom staging showed no local or distant metastases, but one year after resection, we diagnosed a local recurrence. Re-staging, using a fludeoxyglucose positron emission tomography-computed tomogram, (FDG PET-CT) showed suspected accumulations of FDG in the whole axial skeleton. Bone punch biopsy examination confirmed extensive bony metastases, and after resection of the relapse, we began her on a systemic treatment with a Hedgehog-pathway inhibitor (vismodegib), which resulted in partial remission.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EVwHvj
Arthroscopically-assisted short endaural approach for anchorage of the disc of the temporomandibular joint
We describe a new approach to the temporomandibular joint (TMJ), which provides a short endaural access using arthroscopically-assisted surgery. This technique avoids the most common approaches to the TMJ, which may have poor aesthetic outcomes.1,2
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ERilve
Condylectomy: treatment of recurrent unilateral dislocation of the temporomandibular joint in a patient with Ehlers-Danlos syndrome
We report the use of unilateral condylectomy to treat the recurrent dislocation of the temporomandibular joint (TMJ) in a 21-year-old woman with Ehlers-Danlos syndrome. Eighteen months after operation the patient had no further dislocation on full mouth opening, and no surgical complications.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EWsKXs
Changes in position of the hyoid bone and volume of the pharyngeal airway after mandibular setback: three-dimensional analysis
Important aspects of orthognathic surgery are the effects of skeletal movement and changes in the position of the hyoid bone, tongue, soft palate, and dimensions of the pharyngeal airway. Our aims were to evaluate the 3-dimensional changes in the pharyngeal airway and in the position of the hyoid bone after mandibular setback in 30 patients who were diagnosed with mandibular prognathism and were treated by intraoral vertical ramus osteotomy (IVRO). Three-dimensional cone-beam computed tomographic (CT) images were obtained preoperatively, one month postoperatively, and one year postoperatively.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EQ4hSC
Patient Reported Outcome Measures (PROMs) in orthognathic surgery- A two-year follow-up of 418 patients at East Grinstead
Introduction: We are all aware of the positive impact of orthognathic surgery on patient's well-being and quality of life but to demonstrate it to the NHS healthcare commissioners, continuous orthognathic outcomes data need to be collected locally and nationally. We aimed to look at Patient Reported Outcome Measures (PROMs) in orthognathic surgery at the 2-year follow-up at the Queen Victoria Hospital, East Grinstead.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EVwwjD
Corrigendum to `Propeller TAP flap breast reconstruction: A simplified surgical technique' [Journal of Plastic, Reconstructive & Aesthetic Surgery 71 (2018) 1424–1431]
The authors deeply regret that we have discovered an error was made in the Material and methods section, Results section and table 2 of this paper:
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Q8qRYI
Restoring Skeletal Marker Points for Severe Maxillary and Mandibular Jaw Defects Using a Linear Regression Approach
For severe mandibular or maxillary defects across the midline, doctors often lack data on the shape of the jaws when designing virtual surgery. This study sought to repair the personalized 3-dimensional shape of the jaw, particularly when the jaw is severely damaged.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EQUBYc
Rhinolith: Examining the clinical, radiological and surgical features of 23 cases
Rhinolith is a hard nasal mass formed in time by the mineral salts around an endogenous or exogenous-originating nidus. Rhinolith, which is seen rarely, has been reported in the literature as case reports. In this study, we are presenting the demographic and clinical features together with accompanying sinonasal pathologies of 23 rhinolith cases.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EWwbxn
Otitis media with effusion in Nigerian children with cleft palate: incidence and risk factors
Otitis media with effusion is common in children with cleft palate, and the aim of this study was to find out its incidence and risk factors in Nigerians. We prospectively studied 84 patients (42 with cleft palate and 42 control subjects); 27 were male and 15 female, who were age and sex matched with control subjects. The extent and size of the clefts were measured using a dental cast and Vernier calipers, and the otitis media was diagnosed with otoscopy and tympanometry. The mean (SD) age of the groups was 11 (7) months (range 1–33).
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ERRjnv
Extensive bony metastases from facial metatypical basal cell carcinoma: a case report
Metastatic basal cell carcinoma (BCC) is rare. We treated a 44-year-old woman with an extended facial metatypical BCC in whom staging showed no local or distant metastases, but one year after resection, we diagnosed a local recurrence. Re-staging, using a fludeoxyglucose positron emission tomography-computed tomogram, (FDG PET-CT) showed suspected accumulations of FDG in the whole axial skeleton. Bone punch biopsy examination confirmed extensive bony metastases, and after resection of the relapse, we began her on a systemic treatment with a Hedgehog-pathway inhibitor (vismodegib), which resulted in partial remission.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EVwHvj
Arthroscopically-assisted short endaural approach for anchorage of the disc of the temporomandibular joint
We describe a new approach to the temporomandibular joint (TMJ), which provides a short endaural access using arthroscopically-assisted surgery. This technique avoids the most common approaches to the TMJ, which may have poor aesthetic outcomes.1,2
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ERilve
Condylectomy: treatment of recurrent unilateral dislocation of the temporomandibular joint in a patient with Ehlers-Danlos syndrome
We report the use of unilateral condylectomy to treat the recurrent dislocation of the temporomandibular joint (TMJ) in a 21-year-old woman with Ehlers-Danlos syndrome. Eighteen months after operation the patient had no further dislocation on full mouth opening, and no surgical complications.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EWsKXs
Changes in position of the hyoid bone and volume of the pharyngeal airway after mandibular setback: three-dimensional analysis
Important aspects of orthognathic surgery are the effects of skeletal movement and changes in the position of the hyoid bone, tongue, soft palate, and dimensions of the pharyngeal airway. Our aims were to evaluate the 3-dimensional changes in the pharyngeal airway and in the position of the hyoid bone after mandibular setback in 30 patients who were diagnosed with mandibular prognathism and were treated by intraoral vertical ramus osteotomy (IVRO). Three-dimensional cone-beam computed tomographic (CT) images were obtained preoperatively, one month postoperatively, and one year postoperatively.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EQ4hSC
Patient Reported Outcome Measures (PROMs) in orthognathic surgery- A two-year follow-up of 418 patients at East Grinstead
Introduction: We are all aware of the positive impact of orthognathic surgery on patient's well-being and quality of life but to demonstrate it to the NHS healthcare commissioners, continuous orthognathic outcomes data need to be collected locally and nationally. We aimed to look at Patient Reported Outcome Measures (PROMs) in orthognathic surgery at the 2-year follow-up at the Queen Victoria Hospital, East Grinstead.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EVwwjD
Corrigendum to `Propeller TAP flap breast reconstruction: A simplified surgical technique' [Journal of Plastic, Reconstructive & Aesthetic Surgery 71 (2018) 1424–1431]
The authors deeply regret that we have discovered an error was made in the Material and methods section, Results section and table 2 of this paper:
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Q8qRYI
Association of a label of penicillin allergy with increased risk of MRSA and Clostridium difficile infection: DTB Select summary
This journal article gives summary and context to a matched cohort study, that found people with a documented allergy to penicillin have higher rates of MRSA and Clostridium difficile infection. This was influenced by increased use of alternatives to beta-lactam antibiotics. (Source: Current Awareness Service for Health (CASH))
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESrfIQ
Here's the Best Way to Boost Your Immune System
Some people seem to breeze through cold-and-flu season without so much as a sniffle. What's their secret? Regular exercise is a prime candidate. "If you look at all the lifestyle factors that decrease the number of days you suffer from common cold, being a physically active and fit person is the most important," says David Nieman, a professor of public health and director of the Human Performance Lab at Appalachian State University. Nieman has spent years examining the effect exercise has on human health and immune function. In one of his studies, he and his colleagues found that 30 minutes of brisk walking increased the circulation of natural killer cells, white blood cells and other immune system warriors. When these immune cells encounter an illness-causing pathogen, ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESL1Vr
Association of a label of penicillin allergy with increased risk of MRSA and Clostridium difficile infection: DTB Select summary
This journal article gives summary and context to a matched cohort study, that found people with a documented allergy to penicillin have higher rates of MRSA and Clostridium difficile infection. This was influenced by increased use of alternatives to beta-lactam antibiotics. (Source: Current Awareness Service for Health (CASH))
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESrfIQ
Here's the Best Way to Boost Your Immune System
Some people seem to breeze through cold-and-flu season without so much as a sniffle. What's their secret? Regular exercise is a prime candidate. "If you look at all the lifestyle factors that decrease the number of days you suffer from common cold, being a physically active and fit person is the most important," says David Nieman, a professor of public health and director of the Human Performance Lab at Appalachian State University. Nieman has spent years examining the effect exercise has on human health and immune function. In one of his studies, he and his colleagues found that 30 minutes of brisk walking increased the circulation of natural killer cells, white blood cells and other immune system warriors. When these immune cells encounter an illness-causing pathogen, ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESL1Vr
Restoring Skeletal Marker Points for Severe Maxillary and Mandibular Jaw Defects Using a Linear Regression Approach
For severe mandibular or maxillary defects across the midline, doctors often lack data on the shape of the jaws when designing virtual surgery. This study sought to repair the personalized 3-dimensional shape of the jaw, particularly when the jaw is severely damaged.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EQUBYc
Restoring Skeletal Marker Points for Severe Maxillary and Mandibular Jaw Defects Using a Linear Regression Approach
For severe mandibular or maxillary defects across the midline, doctors often lack data on the shape of the jaws when designing virtual surgery. This study sought to repair the personalized 3-dimensional shape of the jaw, particularly when the jaw is severely damaged.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EQUBYc
Carbon fibre/polyether ether ketone (CF/PEEK) implants in orthopaedic oncology
Radiation therapy is an important therapeutic element in musculoskeletal tumours, especially when encountering multiple or painful lesions. In osteolytic lesions, a surgical stabilization with implants is ofte...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2VabJhn
Carbon fibre/polyether ether ketone (CF/PEEK) implants in orthopaedic oncology
Radiation therapy is an important therapeutic element in musculoskeletal tumours, especially when encountering multiple or painful lesions. In osteolytic lesions, a surgical stabilization with implants is ofte...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2VabJhn
Sound therapy (using amplification devices and/or sound generators) for tinnitus.
CONCLUSIONS: There is no evidence to support the superiority of sound therapy for tinnitus over waiting list control, placebo or education/information with no device. There is insufficient evidence to support the superiority or inferiority of any of the sound therapy options (hearing aid, sound generator or combination hearing aid) over each other. The quality of evidence for the reported outcomes, assessed using GRADE, was low. Using a combination device, hearing aid or sound generator might result in little or no difference in tinnitus symptom severity.Future research into the effectiveness of sound therapy in patients with tinnitus should use rigorous methodology. Randomisation and blinding should be of the highest quality, given the subjective nature of tinnitus and the strong likeliho...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AiEG1S
Military and industrial performance: the critical role of noise controls
. (Source: International Journal of Audiology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sowlk8
Sound therapy (using amplification devices and/or sound generators) for tinnitus.
CONCLUSIONS: There is no evidence to support the superiority of sound therapy for tinnitus over waiting list control, placebo or education/information with no device. There is insufficient evidence to support the superiority or inferiority of any of the sound therapy options (hearing aid, sound generator or combination hearing aid) over each other. The quality of evidence for the reported outcomes, assessed using GRADE, was low. Using a combination device, hearing aid or sound generator might result in little or no difference in tinnitus symptom severity.Future research into the effectiveness of sound therapy in patients with tinnitus should use rigorous methodology. Randomisation and blinding should be of the highest quality, given the subjective nature of tinnitus and the strong likeliho...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AiEG1S
Military and industrial performance: the critical role of noise controls
. (Source: International Journal of Audiology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sowlk8
Association of a label of penicillin allergy with increased risk of MRSA and Clostridium difficile infection: DTB Select summary
This journal article gives summary and context to a matched cohort study, that found people with a documented allergy to penicillin have higher rates of MRSA and Clostridium difficile infection. This was influenced by increased use of alternatives to beta-lactam antibiotics. (Source: Current Awareness Service for Health (CASH))
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESrfIQ
Here's the Best Way to Boost Your Immune System
Some people seem to breeze through cold-and-flu season without so much as a sniffle. What's their secret? Regular exercise is a prime candidate. "If you look at all the lifestyle factors that decrease the number of days you suffer from common cold, being a physically active and fit person is the most important," says David Nieman, a professor of public health and director of the Human Performance Lab at Appalachian State University. Nieman has spent years examining the effect exercise has on human health and immune function. In one of his studies, he and his colleagues found that 30 minutes of brisk walking increased the circulation of natural killer cells, white blood cells and other immune system warriors. When these immune cells encounter an illness-causing pathogen, ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESL1Vr
Association of a label of penicillin allergy with increased risk of MRSA and Clostridium difficile infection: DTB Select summary
This journal article gives summary and context to a matched cohort study, that found people with a documented allergy to penicillin have higher rates of MRSA and Clostridium difficile infection. This was influenced by increased use of alternatives to beta-lactam antibiotics. (Source: Current Awareness Service for Health (CASH))
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESrfIQ
Here's the Best Way to Boost Your Immune System
Some people seem to breeze through cold-and-flu season without so much as a sniffle. What's their secret? Regular exercise is a prime candidate. "If you look at all the lifestyle factors that decrease the number of days you suffer from common cold, being a physically active and fit person is the most important," says David Nieman, a professor of public health and director of the Human Performance Lab at Appalachian State University. Nieman has spent years examining the effect exercise has on human health and immune function. In one of his studies, he and his colleagues found that 30 minutes of brisk walking increased the circulation of natural killer cells, white blood cells and other immune system warriors. When these immune cells encounter an illness-causing pathogen, ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ESL1Vr
Asymmetrical Gadolinium Leakage in Ocular Structures in Stroke Due to Internal Carotid Artery Stenosis or Occlusion
Abstract
Purpose
Gadolinium leakage in ocular structures (GLOS) on fluid-attenuated inversion recovery images (FLAIR) is a novel imaging marker in acute ischemic stroke. The present study sought to investigate the frequency and pattern of blood-retina barrier impairment in acute ischemic stroke due to internal carotid artery (ICA) stenosis or occlusion as demonstrated by GLOS.
Methods
From a magnetic resonance imaging (MRI) report database patients were identified with acute ischemic stroke due to ICA stenosis/occlusion who underwent repeated MRI with intravenous contrast agent administration and FLAIR and MR angiography (MRA). On FLAIR the presence of GLOS was noted in the vitreous body.
Results
Overall 51 patients with a median age of 70 years (interquartile range, IQR 63–77 years) were included. Of these, 22 (43.1%) patients had an ICA stenosis and 29 (56.9%) an ICA occlusion. On contrast-enhanced FLAIR, GLOS was observed in 29 (56.9%) patients: in 7 (13.7%) unilateral, in 15 (68.2%) bilateral asymmetrical and in 7 (31.8%) bilateral symmetrical. In unilateral asymmetrical GLOS, more pronounced enhancement was always found ipsilateral to ICA stenosis/occlusion. In 4 (5.9%) patients with asymmetrical GLOS a pre-existing signal increase in the vitreous body was found on native FLAIR. The presence of GLOS was associated with an impaired collateralization through the circle of Willis (p < 0.001) and external carotid artery branches (p = 0.03).
Conclusion
In patients with ischemic stroke due to ICA stenosis/occlusion, GLOS is frequent, commonly unilateral or bilateral asymmetrical, and in some patients associated with pre-existing ocular signal abnormalities. An insufficient collateralization may contribute to the development of unilateral/asymmetrical GLOS.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Skfu1M
Asymmetrical Gadolinium Leakage in Ocular Structures in Stroke Due to Internal Carotid Artery Stenosis or Occlusion
Abstract
Purpose
Gadolinium leakage in ocular structures (GLOS) on fluid-attenuated inversion recovery images (FLAIR) is a novel imaging marker in acute ischemic stroke. The present study sought to investigate the frequency and pattern of blood-retina barrier impairment in acute ischemic stroke due to internal carotid artery (ICA) stenosis or occlusion as demonstrated by GLOS.
Methods
From a magnetic resonance imaging (MRI) report database patients were identified with acute ischemic stroke due to ICA stenosis/occlusion who underwent repeated MRI with intravenous contrast agent administration and FLAIR and MR angiography (MRA). On FLAIR the presence of GLOS was noted in the vitreous body.
Results
Overall 51 patients with a median age of 70 years (interquartile range, IQR 63–77 years) were included. Of these, 22 (43.1%) patients had an ICA stenosis and 29 (56.9%) an ICA occlusion. On contrast-enhanced FLAIR, GLOS was observed in 29 (56.9%) patients: in 7 (13.7%) unilateral, in 15 (68.2%) bilateral asymmetrical and in 7 (31.8%) bilateral symmetrical. In unilateral asymmetrical GLOS, more pronounced enhancement was always found ipsilateral to ICA stenosis/occlusion. In 4 (5.9%) patients with asymmetrical GLOS a pre-existing signal increase in the vitreous body was found on native FLAIR. The presence of GLOS was associated with an impaired collateralization through the circle of Willis (p < 0.001) and external carotid artery branches (p = 0.03).
Conclusion
In patients with ischemic stroke due to ICA stenosis/occlusion, GLOS is frequent, commonly unilateral or bilateral asymmetrical, and in some patients associated with pre-existing ocular signal abnormalities. An insufficient collateralization may contribute to the development of unilateral/asymmetrical GLOS.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Skfu1M
Furry animal allergen component sensitization and clinical outcomes in adult asthma and rhinitis
Publication date: Available online 27 December 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Bright I. Nwaru, Shintaro Suzuki, Linda Ekerljung, Sigrid Sjölander, Roxana Mincheva, Erik P. Rönmark, Madeleine Rådinger, Eva Rönmark, Magnus P. Borres, Bo Lundbäck, Jan Lötvall
Abstract
Background
Sensitization to allergen components has been linked to asthma in children, but studies in adults are lacking.
Objective
To study the relation of sensitization to furry animal allergen components to risk of asthma, rhinitis, and markers of asthma severity in adults.
Methods
From the West Sweden Asthma Study, a random population-representative sample of adults aged 16-75 years, 2006 participants were clinically examined; 1872 were analyzed for serum IgE to a mix of aeroallergens. Those with IgE>0.35 kUA/L to cat, dog or horse were analyzed for specific cat (Fel d 1, Fel d 2, and Fel d 4), dog (Can f 1, Can f 2, Can f 3, and Can f 5), and horse (Equ c 1) allergen components. We defined mono-, double-, and poly-sensitization (>2 components) patterns and applied cluster analysis to derive distinct sensitization clusters.
Results
Sensitization to each allergen component, lipocalins, each sensitization pattern, and each sensitization cluster (non-sensitized, Fel d 1-driven sensitized, and multi-sensitized clusters) was associated with substantial increased risk of asthma, rhinitis, concomitant asthma/rhinitis, and ACT-controlled asthma. Fel d 1, Can f 1, 2, 3, poly-sensitization, and multi-sensitized cluster were further associated with increased FeNO and eosinophil levels, but with lower PD20 methacoline values. There was no association with asthma exacerbations, FEV1 predicted values, emergency visits or regular oral steroid use, and neutrophil levels.
Conclusion
Sensitization to furry animal allergen components are important predictors of asthma, rhinitis and markers of asthma severity with increased blood eosinophils, FeNO, and airway hyper-reactivity.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EOSkwJ
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