A Novel Grading System for Salpingopharyngeal Fold Hypertrophy in Obstructive Sleep Apnoea

Abstract

The present study aimed at reporting the incidence of Salpingopharyngeal Fold (SPF) hypertrophy on Drug Induced Sleep Endoscopy (DISE) in patients with Obstructive Sleep Apnoea (OSA, validate a grading system and analyse the impact of various grades on the clinical presentation while ascertaining its relation with Apnoea-Hypopnoea Index (AHI). A retrospective analysis of 169 patients with polysomnographic confirmation of obstructive sleep apnoea has been done in the study. The DISE video data of 169 patients was evaluated by two ENT surgeons individually and they graded the hypertrophy of the fold as Grade 0 being normal anatomy, Grade 1 being hypertrophy causing partial obstruction and Grade 2 being hypertrophy causing complete obstruction of lateral pharyngeal wall. It was found that the presence of SPF hypertrophy independently adds considerably to the severity of the obstruction, attributing to lateral collapse at the upper retropalatal level and also significantly increases AHI. It is thus advised to consider the grade of SPF hypertrophy while surgically planning the management of patients with OSA.

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Non-atopic eczema in elderly women – Impact of air pollution and genes

Our study extends the limited knowledge about non-atopic eczema in the elderly by showing an association with ambient air pollution and by differentiating this phenotype from genetically driven atopic eczema. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J0DjIj

Human primary immunodeficiency caused by expression of a kinase-dead p110 δ mutant

This case demonstrates the essential contribution of the p110 δ catalytic domain in adaptive immunity function in a patient with expression of a kinase-dead p110δ mutant. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OqxqK9

Imatinib stimulates PGE2 and attenuates cytokine release via EP4 receptor activation

Imatinib increases PGE2 levels which leads to an EP4-dependent reduction in cytokine release. These effects can also be observed in imatinib-treated patients at therapeutic doses, highlighting its potential as an anti-inflammatory agent. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OpceEq

A Novel Grading System for Salpingopharyngeal Fold Hypertrophy in Obstructive Sleep Apnoea

Abstract

The present study aimed at reporting the incidence of Salpingopharyngeal Fold (SPF) hypertrophy on Drug Induced Sleep Endoscopy (DISE) in patients with Obstructive Sleep Apnoea (OSA, validate a grading system and analyse the impact of various grades on the clinical presentation while ascertaining its relation with Apnoea-Hypopnoea Index (AHI). A retrospective analysis of 169 patients with polysomnographic confirmation of obstructive sleep apnoea has been done in the study. The DISE video data of 169 patients was evaluated by two ENT surgeons individually and they graded the hypertrophy of the fold as Grade 0 being normal anatomy, Grade 1 being hypertrophy causing partial obstruction and Grade 2 being hypertrophy causing complete obstruction of lateral pharyngeal wall. It was found that the presence of SPF hypertrophy independently adds considerably to the severity of the obstruction, attributing to lateral collapse at the upper retropalatal level and also significantly increases AHI. It is thus advised to consider the grade of SPF hypertrophy while surgically planning the management of patients with OSA.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Acgm23

Non-atopic eczema in elderly women – Impact of air pollution and genes

Our study extends the limited knowledge about non-atopic eczema in the elderly by showing an association with ambient air pollution and by differentiating this phenotype from genetically driven atopic eczema. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J0DjIj

Human primary immunodeficiency caused by expression of a kinase-dead p110 δ mutant

This case demonstrates the essential contribution of the p110 δ catalytic domain in adaptive immunity function in a patient with expression of a kinase-dead p110δ mutant. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OqxqK9

Imatinib stimulates PGE2 and attenuates cytokine release via EP4 receptor activation

Imatinib increases PGE2 levels which leads to an EP4-dependent reduction in cytokine release. These effects can also be observed in imatinib-treated patients at therapeutic doses, highlighting its potential as an anti-inflammatory agent. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OpceEq

Insight on Molecular and Surface State Photoluminescence of Carbon Dots Revealed Through Solvent Induced Modulations in their Excitation Wavelength Dependent Emission Properties

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00373D, Paper

Poojan Milan Gharat, Jiddhu Chetodhil, A. P. Srivastava, Praseetha PK, Haridas Pal, Sharmistha Dutta Choudhury
This study explores the intriguing modulations in the excitation wavelength dependence of carbon dot photoluminescence (PL), induced by the solvent medium. Our results indicate that different emissive states of carbon...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Insight on Molecular and Surface State Photoluminescence of Carbon Dots Revealed Through Solvent Induced Modulations in their Excitation Wavelength Dependent Emission Properties

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00373D, Paper

Poojan Milan Gharat, Jiddhu Chetodhil, A. P. Srivastava, Praseetha PK, Haridas Pal, Sharmistha Dutta Choudhury
This study explores the intriguing modulations in the excitation wavelength dependence of carbon dot photoluminescence (PL), induced by the solvent medium. Our results indicate that different emissive states of carbon...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma

Allergen-specific immunotherapy (ASIT) has the potential to modify allergic diseases, and it is also considered a potential therapy for allergic asthma. House dust mite (HDM) allergens, a common source of airb...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QTdJYb

Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma

Allergen-specific immunotherapy (ASIT) has the potential to modify allergic diseases, and it is also considered a potential therapy for allergic asthma. House dust mite (HDM) allergens, a common source of airb...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QTdJYb

Increasing trends of anaphylaxis-related events: an analysis of anaphylaxis using nationwide data in Taiwan, 2001 –2013

ConclusionThe incidence rate of anaphylaxis in Taiwan  has increased at an average rate of 5% annually since 2001, paralleling the rising trends in several Western countries. (Source: World Allergy Organization Journal)

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Circulating Epithelial Cell Characterization and Correlation with Remission and Survival in Patients with Thyroid Cancer

Thyroid, Ahead of Print.


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Subtypes of GABAergic cells in the inferior colliculus.

Authors: Schofield BR, Beebe NL Abstract The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physiology, molecular markers - indicate that the GABAergic cells can be divided into at least four subtypes that serve different functions. However, there has yet to emerge a unified scheme for distinguishing these subtypes. The present review discusses these criteria and, where possible, relates the different properties. In contrast to GABAergic cells in cerebral cortex, where subtypes are much more thoroughly characterized, those i...

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Circulating Epithelial Cell Characterization and Correlation with Remission and Survival in Patients with Thyroid Cancer

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAuXJP

Subtypes of GABAergic cells in the inferior colliculus.

Authors: Schofield BR, Beebe NL Abstract The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physiology, molecular markers - indicate that the GABAergic cells can be divided into at least four subtypes that serve different functions. However, there has yet to emerge a unified scheme for distinguishing these subtypes. The present review discusses these criteria and, where possible, relates the different properties. In contrast to GABAergic cells in cerebral cortex, where subtypes are much more thoroughly characterized, those i...

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The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro.

Conclusion: Our findings showed the presence of self-renewing and proliferative subtypes of SGN-NSCs which might serve as a promising source for the regeneration of auditory neurons even in adult mice. PMID: 30309200 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Otorhinolaryngology)

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The connection of pollen concentrations and crowd-sourced symptom data: new insights from daily and seasonal symptom load index data from 2013 to 2017 in Vienna

ConclusionMore than just the seasonal pollen index has to be considered when the SLI of a selected pollen season has to be explained. Cross-reactivity to other pollen types, allergen content and air pollution could play a considerable role. The similar behavior of the SLI in Vienna and a whole region indicate the feasibility of a possible symptom forecast in future and justifies the use of a single pollen monitoring station within a city of the size of Vienna. (Source: World Allergy Organization Journal)

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Significance of the intraindividual variability of HLA IgG antibodies in renal disease patients observed with different beadsets monitored with two different secondary antibodies on a Luminex platform

AbstractThe accurate measurement of anti-HLA alloantibodies in transplant candidates is required for determining the degree of sensitization and for the listing of unacceptable antigens for organ allocation. Both the configuration of the HLA molecules coated on the beads and the nature of detection antibodies may impede assessment of the presence and strength of anti-HLA IgG- with the Luminex single-antigen-bead assay. Sera antibodies of the end-stage renal disease patients were compared using LIFECODES (LC) and LABScreen (LS) beadsets monitored with polyclonal-Fab (IgHPolyFab) and monoclonal-IgG (FcMonoIgG) second antibodies. Positive results at mean fluorescence intensity (MFI)  >  500 (at serum dilution 1/10) were used to calculate panel reactive antibody (cPRA) levels. LS-beadse...

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Distinct roles for Blimp-1 in autoreactive CD4 T cells during priming and effector phase of autoimmune encephalomyelitis

B lymphocyte-induced maturation protein (Blimp-1) is a transcription factor that regulates effector/memory B cells and CD8 T cells. Here we show that Blimp-1 is expressed in both Th1 and Th17 cells in vitro and highly expressed in effector/memory myelin-specific CD4 T cells in experimental autoimmune encephalomyelitis (EAE) mice. The immunized Blimp-1 conditional knockout mice have a significantly delayed disease onset but enhanced disease severity during the effector phase compared to their wild-type littermates, suggesting that Blimp-1 is a unique transcription factor with distinct roles in the regulation of myelin-specific CD4 T cells during priming and effector phase of EAE. (Source: Journal of Neuroimmunology)

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Imatinib stimulates PGE2 and attenuates cytokine release via EP4 receptor activation

Imatinib increases PGE2 levels which leads to an EP4-dependent reduction in cytokine release. These effects can also be observed in imatinib-treated patients at therapeutic doses, highlighting its potential as an anti-inflammatory agent. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OpceEq

Non-atopic eczema in elderly women – Impact of air pollution and genes

Our study extends the limited knowledge about non-atopic eczema in the elderly by showing an association with ambient air pollution and by differentiating this phenotype from genetically driven atopic eczema. (Source: Journal of Allergy and Clinical Immunology)

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Human primary immunodeficiency caused by expression of a kinase-dead p110 δ mutant

This case demonstrates the essential contribution of the p110 δ catalytic domain in adaptive immunity function in a patient with expression of a kinase-dead p110δ mutant. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OqxqK9

The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro.

Conclusion: Our findings showed the presence of self-renewing and proliferative subtypes of SGN-NSCs which might serve as a promising source for the regeneration of auditory neurons even in adult mice. PMID: 30309200 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Otorhinolaryngology)

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The connection of pollen concentrations and crowd-sourced symptom data: new insights from daily and seasonal symptom load index data from 2013 to 2017 in Vienna

ConclusionMore than just the seasonal pollen index has to be considered when the SLI of a selected pollen season has to be explained. Cross-reactivity to other pollen types, allergen content and air pollution could play a considerable role. The similar behavior of the SLI in Vienna and a whole region indicate the feasibility of a possible symptom forecast in future and justifies the use of a single pollen monitoring station within a city of the size of Vienna. (Source: World Allergy Organization Journal)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IYilK5

Significance of the intraindividual variability of HLA IgG antibodies in renal disease patients observed with different beadsets monitored with two different secondary antibodies on a Luminex platform

AbstractThe accurate measurement of anti-HLA alloantibodies in transplant candidates is required for determining the degree of sensitization and for the listing of unacceptable antigens for organ allocation. Both the configuration of the HLA molecules coated on the beads and the nature of detection antibodies may impede assessment of the presence and strength of anti-HLA IgG- with the Luminex single-antigen-bead assay. Sera antibodies of the end-stage renal disease patients were compared using LIFECODES (LC) and LABScreen (LS) beadsets monitored with polyclonal-Fab (IgHPolyFab) and monoclonal-IgG (FcMonoIgG) second antibodies. Positive results at mean fluorescence intensity (MFI)  >  500 (at serum dilution 1/10) were used to calculate panel reactive antibody (cPRA) levels. LS-beadse...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OrNxXP

Distinct roles for Blimp-1 in autoreactive CD4 T cells during priming and effector phase of autoimmune encephalomyelitis

B lymphocyte-induced maturation protein (Blimp-1) is a transcription factor that regulates effector/memory B cells and CD8 T cells. Here we show that Blimp-1 is expressed in both Th1 and Th17 cells in vitro and highly expressed in effector/memory myelin-specific CD4 T cells in experimental autoimmune encephalomyelitis (EAE) mice. The immunized Blimp-1 conditional knockout mice have a significantly delayed disease onset but enhanced disease severity during the effector phase compared to their wild-type littermates, suggesting that Blimp-1 is a unique transcription factor with distinct roles in the regulation of myelin-specific CD4 T cells during priming and effector phase of EAE. (Source: Journal of Neuroimmunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IYwvuG

Imatinib stimulates PGE2 and attenuates cytokine release via EP4 receptor activation

Imatinib increases PGE2 levels which leads to an EP4-dependent reduction in cytokine release. These effects can also be observed in imatinib-treated patients at therapeutic doses, highlighting its potential as an anti-inflammatory agent. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OpceEq

Non-atopic eczema in elderly women – Impact of air pollution and genes

Our study extends the limited knowledge about non-atopic eczema in the elderly by showing an association with ambient air pollution and by differentiating this phenotype from genetically driven atopic eczema. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J0DjIj

Human primary immunodeficiency caused by expression of a kinase-dead p110 δ mutant

This case demonstrates the essential contribution of the p110 δ catalytic domain in adaptive immunity function in a patient with expression of a kinase-dead p110δ mutant. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OqxqK9

Circulating Epithelial Cell Characterization and Correlation with Remission and Survival in Patients with Thyroid Cancer

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAuXJP

Circulating Epithelial Cell Characterization and Correlation with Remission and Survival in Patients with Thyroid Cancer

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVfEyn

Circulating Epithelial Cell Characterization and Correlation with Remission and Survival in Patients with Thyroid Cancer

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAuXJP

Circulating Epithelial Cell Characterization and Correlation with Remission and Survival in Patients with Thyroid Cancer

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVfEyn

Let there be oxygen and T cells

The stroma of solid tumors can exclude or limit immune infiltration, or lead to the recruitment of tumor-promoting rather than tumor-attacking immune cells. This finding was reported by Jayaprakash et al. in this issue of the JCI, and it was particularly prominent in the hypoxic zones of tumors in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer models. A current clinical goal of immune checkpoint blockade (ICB) is to extend its utility to more patients by converting immunologically "cold" tumors that do not provoke a strong immunological response to "hot" tumors that are invaded by swarms of T cells. When the underlying cause is hypoxia linked, the therapeutic combination of simultaneous targeting of hypoxia and immune checkpoints merits exploration in future cli...

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Let there be oxygen and T cells

The stroma of solid tumors can exclude or limit immune infiltration, or lead to the recruitment of tumor-promoting rather than tumor-attacking immune cells. This finding was reported by Jayaprakash et al. in this issue of the JCI, and it was particularly prominent in the hypoxic zones of tumors in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer models. A current clinical goal of immune checkpoint blockade (ICB) is to extend its utility to more patients by converting immunologically "cold" tumors that do not provoke a strong immunological response to "hot" tumors that are invaded by swarms of T cells. When the underlying cause is hypoxia linked, the therapeutic combination of simultaneous targeting of hypoxia and immune checkpoints merits exploration in future cli...

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What Was the Name of ASHA ’ s First Journal?

Next month we turn our clocks back as daylight-saving time ends for most of the country. Here at ASHA—at least for those of us maintaining the archives—we already turned back to the year 1936. In honor of October being American Archives Month, the ASHA Archives staff created a new online exhibit sharing the history of our scientific journals. In launching the journals' long and distinguished history, ASHA printed the first issue of its first journal, Journal of Speech Disorders, in March of 1936. The first issue contained four articles spread across 34 pages. ASHA saw a steady growth in its journals program over the next 60 years. Along the way, journal titles changed, publications merged, some ended, and eventually they all began publishing exclusively online. Each change reflec...

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What Was the Name of ASHA ’ s First Journal?

Next month we turn our clocks back as daylight-saving time ends for most of the country. Here at ASHA—at least for those of us maintaining the archives—we already turned back to the year 1936. In honor of October being American Archives Month, the ASHA Archives staff created a new online exhibit sharing the history of our scientific journals. In launching the journals' long and distinguished history, ASHA printed the first issue of its first journal, Journal of Speech Disorders, in March of 1936. The first issue contained four articles spread across 34 pages. ASHA saw a steady growth in its journals program over the next 60 years. Along the way, journal titles changed, publications merged, some ended, and eventually they all began publishing exclusively online. Each change reflec...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ezi4Ph

The connection of pollen concentrations and crowd-sourced symptom data: new insights from daily and seasonal symptom load index data from 2013 to 2017 in Vienna

Online pollen diaries and mobile applications nowadays allow easy and fast documentation of pollen allergy symptoms. Such crowd-sourced symptom data provides insights into the development and the onset of a po...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PCFrby

The connection of pollen concentrations and crowd-sourced symptom data: new insights from daily and seasonal symptom load index data from 2013 to 2017 in Vienna

Online pollen diaries and mobile applications nowadays allow easy and fast documentation of pollen allergy symptoms. Such crowd-sourced symptom data provides insights into the development and the onset of a po...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PCFrby

Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma

Abstract

Background

Allergen-specific immunotherapy (ASIT) has the potential to modify allergic diseases, and it is also considered a potential therapy for allergic asthma. House dust mite (HDM) allergens, a common source of airborne allergen in human diseases, have been developed as an immunotherapy for patients with allergic asthma via the subcutaneous and sublingual routes. Oral immunotherapy with repeated allergen ingestion is emerging as another potential modality of ASIT. The aim of this study was to evaluate the therapeutic efficacy of the oral ingestion of HDM extracts in a murine model of allergic asthma.

Methods

BABL/c mice were sensitized twice by intraperitoneal injection of HDM extracts and Al(OH)₃ on day 1 and day 8. Then, the mice received challenge to induce airway inflammation by intratracheal instillation of HDM extracts on days 29–31. The treatment group received immunotherapy with oral HDM extracts ingestion before the challenge. All the mice were sacrificed on day 32 for bronchoalveolar inflammatory cytokines, mediastinal lymph node T cells, lung histology, and serum HDM-specific immunoglobulins analyses.

Results

Upon HDM sensitization and following challenge, a robust Th2 cell response and eosinophilic airway inflammation were observed in mice of the positive control group. The mice treated with HDM extracts ingestion had decreased eosinophilic airway inflammation, suppressed HDM-specific Th2 cell responses in the mediastinal lymph nodes, and attenuated serum HDM-specific IgE levels.

Conclusions

Oral immunotherapy with HDM extracts ingestion was demonstrated to have a partial therapeutic effect in the murine model of allergic asthma. This study may serve as the basis for the further development of oral immunotherapy with HDM extracts in allergic asthma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OZjqGR

Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma

Abstract

Background

Allergen-specific immunotherapy (ASIT) has the potential to modify allergic diseases, and it is also considered a potential therapy for allergic asthma. House dust mite (HDM) allergens, a common source of airborne allergen in human diseases, have been developed as an immunotherapy for patients with allergic asthma via the subcutaneous and sublingual routes. Oral immunotherapy with repeated allergen ingestion is emerging as another potential modality of ASIT. The aim of this study was to evaluate the therapeutic efficacy of the oral ingestion of HDM extracts in a murine model of allergic asthma.

Methods

BABL/c mice were sensitized twice by intraperitoneal injection of HDM extracts and Al(OH)₃ on day 1 and day 8. Then, the mice received challenge to induce airway inflammation by intratracheal instillation of HDM extracts on days 29–31. The treatment group received immunotherapy with oral HDM extracts ingestion before the challenge. All the mice were sacrificed on day 32 for bronchoalveolar inflammatory cytokines, mediastinal lymph node T cells, lung histology, and serum HDM-specific immunoglobulins analyses.

Results

Upon HDM sensitization and following challenge, a robust Th2 cell response and eosinophilic airway inflammation were observed in mice of the positive control group. The mice treated with HDM extracts ingestion had decreased eosinophilic airway inflammation, suppressed HDM-specific Th2 cell responses in the mediastinal lymph nodes, and attenuated serum HDM-specific IgE levels.

Conclusions

Oral immunotherapy with HDM extracts ingestion was demonstrated to have a partial therapeutic effect in the murine model of allergic asthma. This study may serve as the basis for the further development of oral immunotherapy with HDM extracts in allergic asthma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OZjqGR

HIV-positive infants are at high risk for acquiring congenital cytomegalovirus infection

FINDINGSInfants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone to CMV infection.The researchers found that 23 percent of the infants who became infected with HIV during the mother 's pregnancy also were infected with CMV; 18 percent who were infected with HIV either during pregnancy or birth acquired congenital CMV; and 4.9 percent who were exposed to HIV but remained uninfected with that virus also acquired congenital CMV.Overall, HIV-infected infants were four times as likely to have acquired congenital cytomegalovirus   infection compared to infants who were exposed to, but remained uninfected with, HIV. HIV-positive infants who were infected during the ...

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HIV-positive infants are at high risk for acquiring congenital cytomegalovirus infection

FINDINGSInfants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone to CMV infection.The researchers found that 23 percent of the infants who became infected with HIV during the mother 's pregnancy also were infected with CMV; 18 percent who were infected with HIV either during pregnancy or birth acquired congenital CMV; and 4.9 percent who were exposed to HIV but remained uninfected with that virus also acquired congenital CMV.Overall, HIV-infected infants were four times as likely to have acquired congenital cytomegalovirus   infection compared to infants who were exposed to, but remained uninfected with, HIV. HIV-positive infants who were infected during the ...

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Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

Abstract

Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuropsychological testing for assessment of cognitive change after cardiac surgery. This body of work consistently documented decline in cognitive function in elderly patients after anaesthesia and surgery, and cognitive changes have been identified up to 7.5 yr afterwards. Importantly, other studies have identified that the incidence of cognitive change is similar after non-cardiac surgery. Other than the inclusion of non-surgical control groups to calculate postoperative cognitive dysfunction, research into these cognitive changes in the perioperative period has been undertaken in isolation from cognitive studies in the general population. The aim of this work is to develop similar terminology to that used in cognitive classifications of the general population for use in investigations of cognitive changes after anaesthesia and surgery. A multispecialty working group followed a modified Delphi procedure with no prespecified number of rounds comprised of three face-to-face meetings followed by online editing of draft versions.

Two major classification guidelines [Diagnostic and Statistical Manual for Mental Disorders, fifth edition (DSM-5) and National Institute for Aging and the Alzheimer Association (NIA-AA)] are used outside of anaesthesia and surgery, and may be useful for inclusion of biomarkers in research. For clinical purposes, it is recommended to use the DSM-5 nomenclature. The working group recommends that 'perioperative neurocognitive disorders' be used as an overarching term for cognitive impairment identified in the preoperative or postoperative period. This includes cognitive decline diagnosed before operation (described as neurocognitive disorder); any form of acute event (postoperative delirium) and cognitive decline diagnosed up to 30 days after the procedure (delayed neurocognitive recovery) and up to 12 months (postoperative neurocognitive disorder).

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By any other name: consensus in the nomenclature of perioperative neurocognitive disorders

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Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

Abstract

Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuropsychological testing for assessment of cognitive change after cardiac surgery. This body of work consistently documented decline in cognitive function in elderly patients after anaesthesia and surgery, and cognitive changes have been identified up to 7.5 yr afterwards. Importantly, other studies have identified that the incidence of cognitive change is similar after non-cardiac surgery. Other than the inclusion of non-surgical control groups to calculate postoperative cognitive dysfunction, research into these cognitive changes in the perioperative period has been undertaken in isolation from cognitive studies in the general population. The aim of this work is to develop similar terminology to that used in cognitive classifications of the general population for use in investigations of cognitive changes after anaesthesia and surgery. A multispecialty working group followed a modified Delphi procedure with no prespecified number of rounds comprised of three face-to-face meetings followed by online editing of draft versions.

Two major classification guidelines [Diagnostic and Statistical Manual for Mental Disorders, fifth edition (DSM-5) and National Institute for Aging and the Alzheimer Association (NIA-AA)] are used outside of anaesthesia and surgery, and may be useful for inclusion of biomarkers in research. For clinical purposes, it is recommended to use the DSM-5 nomenclature. The working group recommends that 'perioperative neurocognitive disorders' be used as an overarching term for cognitive impairment identified in the preoperative or postoperative period. This includes cognitive decline diagnosed before operation (described as neurocognitive disorder); any form of acute event (postoperative delirium) and cognitive decline diagnosed up to 30 days after the procedure (delayed neurocognitive recovery) and up to 12 months (postoperative neurocognitive disorder).

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By any other name: consensus in the nomenclature of perioperative neurocognitive disorders

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What Was the Name of ASHA ’ s First Journal?

Next month we turn our clocks back as daylight-saving time ends for most of the country. Here at ASHA—at least for those of us maintaining the archives—we already turned back to the year 1936. In honor of October being American Archives Month, the ASHA Archives staff created a new online exhibit sharing the history of our scientific journals. In launching the journals' long and distinguished history, ASHA printed the first issue of its first journal, Journal of Speech Disorders, in March of 1936. The first issue contained four articles spread across 34 pages. ASHA saw a steady growth in its journals program over the next 60 years. Along the way, journal titles changed, publications merged, some ended, and eventually they all began publishing exclusively online. Each change reflec...

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What Was the Name of ASHA ’ s First Journal?

Next month we turn our clocks back as daylight-saving time ends for most of the country. Here at ASHA—at least for those of us maintaining the archives—we already turned back to the year 1936. In honor of October being American Archives Month, the ASHA Archives staff created a new online exhibit sharing the history of our scientific journals. In launching the journals' long and distinguished history, ASHA printed the first issue of its first journal, Journal of Speech Disorders, in March of 1936. The first issue contained four articles spread across 34 pages. ASHA saw a steady growth in its journals program over the next 60 years. Along the way, journal titles changed, publications merged, some ended, and eventually they all began publishing exclusively online. Each change reflec...

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What Was the Name of ASHA ’ s First Journal?

Next month we turn our clocks back as daylight-saving time ends for most of the country. Here at ASHA—at least for those of us maintaining the archives—we already turned back to the year 1936. In honor of October being American Archives Month, the ASHA Archives staff created a new online exhibit sharing the history of our scientific journals. In launching the journals' long and distinguished history, ASHA printed the first issue of its first journal, Journal of Speech Disorders, in March of 1936. The first issue contained four articles spread across 34 pages. ASHA saw a steady growth in its journals program over the next 60 years. Along the way, journal titles changed, publications merged, some ended, and eventually they all began publishing exclusively online. Each change reflec...

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Deciphering a Metaphor

I have been thinking about my lastpost andHubert Haiber 's argument that "Natural languages have the properties they have because they reflect the properties which our language-learning and language-using human brain capacities can cope with." ( SeeAn anthropic principle in lieu of a "Universal Grammar) This principle might seem self-evident, even circular, but it is a direct challenge to the concept of an innate, universal grammar. Indeed, Haiber is attacking Chomsky 's innate (a.k.a. nativist) principle directly: "Nobody has ever been able to produce immediate and compelling evidence in favour of the strong nativist hypothesis." Disagreeing with Chomsky is hardly news, and I would probably let the paper pass by if it weren't for a second feature, the me taphor of grammar ...

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What Was the Name of ASHA ’ s First Journal?

Next month we turn our clocks back as daylight-saving time ends for most of the country. Here at ASHA—at least for those of us maintaining the archives—we already turned back to the year 1936. In honor of October being American Archives Month, the ASHA Archives staff created a new online exhibit sharing the history of our scientific journals. In launching the journals' long and distinguished history, ASHA printed the first issue of its first journal, Journal of Speech Disorders, in March of 1936. The first issue contained four articles spread across 34 pages. ASHA saw a steady growth in its journals program over the next 60 years. Along the way, journal titles changed, publications merged, some ended, and eventually they all began publishing exclusively online. Each change reflec...

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The connection of pollen concentrations and crowd-sourced symptom data: new insights from daily and seasonal symptom load index data from 2013 to 2017 in Vienna

Abstract

Background

Online pollen diaries and mobile applications nowadays allow easy and fast documentation of pollen allergy symptoms. Such crowd-sourced symptom data provides insights into the development and the onset of a pollen allergy. Hitherto studies of the symptom load index (SLI) showed a discrepancy between the SLI and the total pollen amount of a season, but did not analyze the daily data.

Methods

The Patient's Hayfever Diary (PHD) was used as data pool for symptom data. Symptom data of Vienna (Austria) was chosen as a large and local sample size within the study period of 2013 until 2017. The city was divided into three different areas based on equal population densities and different environmental factors. Correlation factors, regression lines, locally weighted smoothing (LOESS) curves and line plots were calculated to examine the data.

Results

Daily SLI and pollen concentration data correlates well and the progress of the SLI within a pollen season is mirrored by the pollen concentrations. The LOESS curves do not deviate much from the regression line and support the linearity of the symptom-pollen correlation on a daily basis. Seasonal SLI data does not follow the same pattern as the respective seasonal pollen indices. Results did not vary in the three areas within Vienna or when compared with the Eastern region of Austria showing no significant spatial variation of the SLI.

Discussion

Results indicate a linear relationship of the SLI and pollen concentrations/seasonal polllen index (SPIn) on a daily basis for both in general and throughout the season, but not on a seasonal basis. These findings clarify the frequent misinterpretation of the SLI as index that is tightly connected to pollen concentrations, but reflects as well the seasonal variation of the burden of pollen allergy sufferers.

Conclusion

More than just the seasonal pollen index has to be considered when the SLI of a selected pollen season has to be explained. Cross-reactivity to other pollen types, allergen content and air pollution could play a considerable role. The similar behavior of the SLI in Vienna and a whole region indicate the feasibility of a possible symptom forecast in future and justifies the use of a single pollen monitoring station within a city of the size of Vienna.

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The connection of pollen concentrations and crowd-sourced symptom data: new insights from daily and seasonal symptom load index data from 2013 to 2017 in Vienna

Abstract

Background

Online pollen diaries and mobile applications nowadays allow easy and fast documentation of pollen allergy symptoms. Such crowd-sourced symptom data provides insights into the development and the onset of a pollen allergy. Hitherto studies of the symptom load index (SLI) showed a discrepancy between the SLI and the total pollen amount of a season, but did not analyze the daily data.

Methods

The Patient's Hayfever Diary (PHD) was used as data pool for symptom data. Symptom data of Vienna (Austria) was chosen as a large and local sample size within the study period of 2013 until 2017. The city was divided into three different areas based on equal population densities and different environmental factors. Correlation factors, regression lines, locally weighted smoothing (LOESS) curves and line plots were calculated to examine the data.

Results

Daily SLI and pollen concentration data correlates well and the progress of the SLI within a pollen season is mirrored by the pollen concentrations. The LOESS curves do not deviate much from the regression line and support the linearity of the symptom-pollen correlation on a daily basis. Seasonal SLI data does not follow the same pattern as the respective seasonal pollen indices. Results did not vary in the three areas within Vienna or when compared with the Eastern region of Austria showing no significant spatial variation of the SLI.

Discussion

Results indicate a linear relationship of the SLI and pollen concentrations/seasonal polllen index (SPIn) on a daily basis for both in general and throughout the season, but not on a seasonal basis. These findings clarify the frequent misinterpretation of the SLI as index that is tightly connected to pollen concentrations, but reflects as well the seasonal variation of the burden of pollen allergy sufferers.

Conclusion

More than just the seasonal pollen index has to be considered when the SLI of a selected pollen season has to be explained. Cross-reactivity to other pollen types, allergen content and air pollution could play a considerable role. The similar behavior of the SLI in Vienna and a whole region indicate the feasibility of a possible symptom forecast in future and justifies the use of a single pollen monitoring station within a city of the size of Vienna.

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Social communication assessment after TBI: a narrative review of innovations in pragmatic and discourse assessment methods - Steel J, Togher L.

BACKGROUND: Social communication assessment after traumatic brain injury (TBI) remains a challenging area within speech-language pathology (SLP) clinical practice. Difficulties include the lack of TBI-specific standardized assessment instruments and limite... (Source: SafetyLit)

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WATCH: A speech therapy session with US's youngest face transplant recipient

A year after her surgery, Katie Stubblefield is still adjusting to life with her new face, which includes learning how to talk again. (Source: ABC News: Health)

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Social communication assessment after TBI: a narrative review of innovations in pragmatic and discourse assessment methods - Steel J, Togher L.

BACKGROUND: Social communication assessment after traumatic brain injury (TBI) remains a challenging area within speech-language pathology (SLP) clinical practice. Difficulties include the lack of TBI-specific standardized assessment instruments and limite... (Source: SafetyLit)

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WATCH: A speech therapy session with US's youngest face transplant recipient

A year after her surgery, Katie Stubblefield is still adjusting to life with her new face, which includes learning how to talk again. (Source: ABC News: Health)

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HIV-positive infants are at high risk for acquiring congenital cytomegalovirus infection

FINDINGSInfants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone to CMV infection.The researchers found that 23 percent of the infants who became infected with HIV during the mother 's pregnancy also were infected with CMV; 18 percent who were infected with HIV either during pregnancy or birth acquired congenital CMV; and 4.9 percent who were exposed to HIV but remained uninfected with that virus also acquired congenital CMV.Overall, HIV-infected infants were four times as likely to have acquired congenital cytomegalovirus   infection compared to infants who were exposed to, but remained uninfected with, HIV. HIV-positive infants who were infected during the ...

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Thymoproteasome and peptidic self

AbstractPositive selection of T cells in the thymus is induced by low-affinity TCR recognition of self-peptide-MHC complexes expressed by cortical thymic epithelial cells (cTECs). cTECs express a specialized type of proteasomes, the thymoproteasome, which generates a unique spectrum of MHC class I-associated peptides and plays a critical role in thymic positive selection of CD8+ T cells. However, it remains unclear how the thymoproteasome contributes to the thymic positive selection. More than 30  years ago, the "peptidic self" hypothesis proposed that TCRs recognize MHC-presented peptides only, without interacting with MHC molecules, which turned out to be incorrect. Interestingly, however, by implying that a set of MHC-associated peptides forms immunological self, this hypothesis al...

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HIV-positive infants are at high risk for acquiring congenital cytomegalovirus infection

FINDINGSInfants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone to CMV infection.The researchers found that 23 percent of the infants who became infected with HIV during the mother 's pregnancy also were infected with CMV; 18 percent who were infected with HIV either during pregnancy or birth acquired congenital CMV; and 4.9 percent who were exposed to HIV but remained uninfected with that virus also acquired congenital CMV.Overall, HIV-infected infants were four times as likely to have acquired congenital cytomegalovirus   infection compared to infants who were exposed to, but remained uninfected with, HIV. HIV-positive infants who were infected during the ...

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Thymoproteasome and peptidic self

AbstractPositive selection of T cells in the thymus is induced by low-affinity TCR recognition of self-peptide-MHC complexes expressed by cortical thymic epithelial cells (cTECs). cTECs express a specialized type of proteasomes, the thymoproteasome, which generates a unique spectrum of MHC class I-associated peptides and plays a critical role in thymic positive selection of CD8+ T cells. However, it remains unclear how the thymoproteasome contributes to the thymic positive selection. More than 30  years ago, the "peptidic self" hypothesis proposed that TCRs recognize MHC-presented peptides only, without interacting with MHC molecules, which turned out to be incorrect. Interestingly, however, by implying that a set of MHC-associated peptides forms immunological self, this hypothesis al...

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The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal

Condition:   Penicillin Allergy Intervention:   Other: Penicillin Allergic Risk Stratification Best Practice Alert Sponsors:   Vanderbilt University Medical Center;   Vanderbilt Institute for Clinical and Translational Research (Learning Healthcare System) Not yet recruiting (Source: ClinicalTrials.gov)

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Durability and Impact of the Seasonal Influenza Vaccine on H5 Induced B Cell Response

Condition:   Influenza A Subtype H5N1 Infection Intervention:   Biological: Seasonal Influenza Vaccine Sponsors:   Emory University;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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FLUAD vs. FLUZONE HD Influenza Vaccine in Residents of Long Term Care

Condition:   Flu Interventions:   Drug: Fluad Vaccine;   Drug: Fluzone HD Vaccine Sponsors:   David H. Canaday;   Case Western Reserve University;   US Department of Veterans Affairs;   Brown University;   National Institutes of Health (NIH);   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Food Allergy Diagnostic Test Response to Previous Oral Challenge Response

Condition:   Food Hypersensitivity Intervention:   Other: Conjunctival Allergen Challenge Sponsor:   ORA, Inc. Completed (Source: ClinicalTrials.gov)

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Partnership Is Key To Better Patient Programs

Online shoppers do not struggle when using Amazon or eBay. Over the last 20 years, ecommerce providers have coalesced around a common set of tools to help shoppers find what they want.As the healthcare sector focuses on developing digitized patient support programs, it needs to understand how a similar sense of usability will emerge.At arecent webinar, organized by eyeforpharma and S3 Connected Health, we polled 234 participants to understand how they see patient support programs (PSPs) developing.It is clear the stakes are high; 40% said they were'a significant way to make medicine more holistic', while 38% said PSPs would be'the primary or essential way to support patients'in the future.The senior pharma execs participating in the webinar also saw the next generation of PSPs as part of a...

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The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal

Condition:   Penicillin Allergy Intervention:   Other: Penicillin Allergic Risk Stratification Best Practice Alert Sponsors:   Vanderbilt University Medical Center;   Vanderbilt Institute for Clinical and Translational Research (Learning Healthcare System) Not yet recruiting (Source: ClinicalTrials.gov)

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Durability and Impact of the Seasonal Influenza Vaccine on H5 Induced B Cell Response

Condition:   Influenza A Subtype H5N1 Infection Intervention:   Biological: Seasonal Influenza Vaccine Sponsors:   Emory University;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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FLUAD vs. FLUZONE HD Influenza Vaccine in Residents of Long Term Care

Condition:   Flu Interventions:   Drug: Fluad Vaccine;   Drug: Fluzone HD Vaccine Sponsors:   David H. Canaday;   Case Western Reserve University;   US Department of Veterans Affairs;   Brown University;   National Institutes of Health (NIH);   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Food Allergy Diagnostic Test Response to Previous Oral Challenge Response

Condition:   Food Hypersensitivity Intervention:   Other: Conjunctival Allergen Challenge Sponsor:   ORA, Inc. Completed (Source: ClinicalTrials.gov)

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Partnership Is Key To Better Patient Programs

Online shoppers do not struggle when using Amazon or eBay. Over the last 20 years, ecommerce providers have coalesced around a common set of tools to help shoppers find what they want.As the healthcare sector focuses on developing digitized patient support programs, it needs to understand how a similar sense of usability will emerge.At arecent webinar, organized by eyeforpharma and S3 Connected Health, we polled 234 participants to understand how they see patient support programs (PSPs) developing.It is clear the stakes are high; 40% said they were'a significant way to make medicine more holistic', while 38% said PSPs would be'the primary or essential way to support patients'in the future.The senior pharma execs participating in the webinar also saw the next generation of PSPs as part of a...

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Orthognathic Surgery Has a Significant Positive Effect on Perceived Personality Traits and Perceived Emotional Expressions in Long Face Subjects

Crowdsourcing is increasingly being used in medical research to obtain the opinion and perception of laypeople. The investigators hypothesized that a layperson's perception of a long-face dentofacial deformity (DFD) patient is more favorable after orthognathic surgery than before surgery with regard to perceived personality traits and emotional facial expressions.

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Orthognathic Surgery Has a Significant Positive Effect on Perceived Personality Traits and Perceived Emotional Expressions in Long Face Subjects

Crowdsourcing is increasingly being used in medical research to obtain the opinion and perception of laypeople. The investigators hypothesized that a layperson's perception of a long-face dentofacial deformity (DFD) patient is more favorable after orthognathic surgery than before surgery with regard to perceived personality traits and emotional facial expressions.

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Endoscopic Management of Subperiosteal Orbital Abscesses

While the progression of acute rhinosinusitis to orbital infections has decreased in the modern antibiotic era, they still occur, particularly in the pediatric population. Infection may spread from the nasal cavity and sinuses via direct extension into the orbit through the thin lamina papyracea or through the valveless veins in the bony orbital wall.1 Congenital dehiscence and trauma also allow for direct extension of the infection to the orbit.1 Most of these orbital infections originate in the ethmoid sinuses and subperiosteal abscesses most commonly occur along the medial orbital wall.

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Contrast-enhanced CT image assessment of cervical lymph node metastasis in oral cancer patients using a deep learning system of artificial intelligence

Although deep learning has been applied to medical images, its application to the diagnosis of cervical lymph nodes in patients with oral cancer has not yet been reported. The purpose of this study was to evaluate the performance of deep-learning image classification for diagnosis of lymph node metastasis.

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Endoscopic Management of Subperiosteal Orbital Abscesses

While the progression of acute rhinosinusitis to orbital infections has decreased in the modern antibiotic era, they still occur, particularly in the pediatric population. Infection may spread from the nasal cavity and sinuses via direct extension into the orbit through the thin lamina papyracea or through the valveless veins in the bony orbital wall.1 Congenital dehiscence and trauma also allow for direct extension of the infection to the orbit.1 Most of these orbital infections originate in the ethmoid sinuses and subperiosteal abscesses most commonly occur along the medial orbital wall.

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Contrast-enhanced CT image assessment of cervical lymph node metastasis in oral cancer patients using a deep learning system of artificial intelligence

Although deep learning has been applied to medical images, its application to the diagnosis of cervical lymph nodes in patients with oral cancer has not yet been reported. The purpose of this study was to evaluate the performance of deep-learning image classification for diagnosis of lymph node metastasis.

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A multiple target chemosensor for the sequential fluorescence detection of Zn2+ and S2- and the colorimetric detection of Fe3+/2+ in aqueous media and living cells

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00408K, Paper

Cheal Kim, Jin Yeong Yun, Ju Chae, Mingeun Kim, Mi Hee Lim
A novel multiple target sensor, (E)-5-((4-(diethylamino)-2-hydroxybenzyldene)amino)-1H-imidazole-4-carboxamide (DHIC), was synthesized for fluorescence detection of Zn2+ and S2- and colorimetry detection of Fe3+/2+ in aqueous media. The DHIC can operate as turn...
The content of this RSS Feed (c) The Royal Society of Chemistry

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A multiple target chemosensor for the sequential fluorescence detection of Zn2+ and S2- and the colorimetric detection of Fe3+/2+ in aqueous media and living cells

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00408K, Paper

Cheal Kim, Jin Yeong Yun, Ju Chae, Mingeun Kim, Mi Hee Lim
A novel multiple target sensor, (E)-5-((4-(diethylamino)-2-hydroxybenzyldene)amino)-1H-imidazole-4-carboxamide (DHIC), was synthesized for fluorescence detection of Zn2+ and S2- and colorimetry detection of Fe3+/2+ in aqueous media. The DHIC can operate as turn...
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QQ6NLu

Orthognathic Surgery Has a Significant Positive Effect on Perceived Personality Traits and Perceived Emotional Expressions in Long Face Subjects

Crowdsourcing is increasingly being used in medical research to obtain the opinion and perception of laypeople. The investigators hypothesized that a layperson's perception of a long-face dentofacial deformity (DFD) patient is more favorable after orthognathic surgery than before surgery with regard to perceived personality traits and emotional facial expressions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QVpbCT

Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant

This case demonstrates the essential contribution of the p110δ catalytic domain in adaptive immunity function in a patient with expression of a kinase-dead p110δ mutant.

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Non-atopic eczema in elderly women – Impact of air pollution and genes

Our study extends the limited knowledge about non-atopic eczema in the elderly by showing an association with ambient air pollution and by differentiating this phenotype from genetically driven atopic eczema.

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Imatinib stimulates PGE2 and attenuates cytokine release via EP4 receptor activation

Imatinib increases PGE2 levels which leads to an EP4-dependent reduction in cytokine release. These effects can also be observed in imatinib-treated patients at therapeutic doses, highlighting its potential as an anti-inflammatory agent.

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Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant

This case demonstrates the essential contribution of the p110δ catalytic domain in adaptive immunity function in a patient with expression of a kinase-dead p110δ mutant.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OoRIE1

Non-atopic eczema in elderly women – Impact of air pollution and genes

Our study extends the limited knowledge about non-atopic eczema in the elderly by showing an association with ambient air pollution and by differentiating this phenotype from genetically driven atopic eczema.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yGRIVe

Imatinib stimulates PGE2 and attenuates cytokine release via EP4 receptor activation

Imatinib increases PGE2 levels which leads to an EP4-dependent reduction in cytokine release. These effects can also be observed in imatinib-treated patients at therapeutic doses, highlighting its potential as an anti-inflammatory agent.

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Partnership Is Key To Better Patient Programs

Online shoppers do not struggle when using Amazon or eBay. Over the last 20 years, ecommerce providers have coalesced around a common set of tools to help shoppers find what they want.As the healthcare sector focuses on developing digitized patient support programs, it needs to understand how a similar sense of usability will emerge.At arecent webinar, organized by eyeforpharma and S3 Connected Health, we polled 234 participants to understand how they see patient support programs (PSPs) developing.It is clear the stakes are high; 40% said they were'a significant way to make medicine more holistic', while 38% said PSPs would be'the primary or essential way to support patients'in the future.The senior pharma execs participating in the webinar also saw the next generation of PSPs as part of a...

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Walter Reed Army Institute of Research begins phase 1 clinical trial of Marburg vaccine

(Walter Reed Army Institute of Research) WRAIR this week administered the first vaccine in a Phase 1 clinical trial to evaluate the safety and immunogenicity of a Marburg vaccine candidate in healthy adult volunteers. The WRAIR study evaluates the VRC-MARADC087-00-VP vaccine, developed by the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The Marburg virus is in the same family as Ebola and causes severe hemorrhagic fever in humans. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Frequency of CD8 + regulatory T cells in the multiple sclerosis patients: a systematic review and meta-analysis

AbstractMultiple sclerosis (MS) is a neuro-immunological demyelinating disease. From the immunological aspects, it is well accepted that T cells play a pivotal role in the etiology of the disease. T helper (Th) 1 and Th17 cells are thought to be the main pathogenic T cells in the pathogenesis of MS and are known as effector T cells. As the self-reactive T lymphocytes can escape clonal deletion in the thymus and subsequently are released into the periphery, there is an urgent need for peripheral tolerance, which is executed by the specialized regulatory T (Treg) cells. Interestingly, CD8+ regulatory T (Treg) cells have also been identified among lymphocyte subtypes. The peripheral CD8+ Treg cells frequency in MS subjects in comparison with healthy controls is the objective of the current st...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J01rui

Partnership Is Key To Better Patient Programs

Online shoppers do not struggle when using Amazon or eBay. Over the last 20 years, ecommerce providers have coalesced around a common set of tools to help shoppers find what they want.As the healthcare sector focuses on developing digitized patient support programs, it needs to understand how a similar sense of usability will emerge.At arecent webinar, organized by eyeforpharma and S3 Connected Health, we polled 234 participants to understand how they see patient support programs (PSPs) developing.It is clear the stakes are high; 40% said they were'a significant way to make medicine more holistic', while 38% said PSPs would be'the primary or essential way to support patients'in the future.The senior pharma execs participating in the webinar also saw the next generation of PSPs as part of a...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Oq56HP

Walter Reed Army Institute of Research begins phase 1 clinical trial of Marburg vaccine

(Walter Reed Army Institute of Research) WRAIR this week administered the first vaccine in a Phase 1 clinical trial to evaluate the safety and immunogenicity of a Marburg vaccine candidate in healthy adult volunteers. The WRAIR study evaluates the VRC-MARADC087-00-VP vaccine, developed by the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The Marburg virus is in the same family as Ebola and causes severe hemorrhagic fever in humans. (Source: EurekAlert! - Infectious and Emerging Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OWVdRD

Frequency of CD8 + regulatory T cells in the multiple sclerosis patients: a systematic review and meta-analysis

AbstractMultiple sclerosis (MS) is a neuro-immunological demyelinating disease. From the immunological aspects, it is well accepted that T cells play a pivotal role in the etiology of the disease. T helper (Th) 1 and Th17 cells are thought to be the main pathogenic T cells in the pathogenesis of MS and are known as effector T cells. As the self-reactive T lymphocytes can escape clonal deletion in the thymus and subsequently are released into the periphery, there is an urgent need for peripheral tolerance, which is executed by the specialized regulatory T (Treg) cells. Interestingly, CD8+ regulatory T (Treg) cells have also been identified among lymphocyte subtypes. The peripheral CD8+ Treg cells frequency in MS subjects in comparison with healthy controls is the objective of the current st...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J01rui

Social communication assessment after TBI: a narrative review of innovations in pragmatic and discourse assessment methods - Steel J, Togher L.

BACKGROUND: Social communication assessment after traumatic brain injury (TBI) remains a challenging area within speech-language pathology (SLP) clinical practice. Difficulties include the lack of TBI-specific standardized assessment instruments and limite... (Source: SafetyLit)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ym2lNG

WATCH: A speech therapy session with US's youngest face transplant recipient

A year after her surgery, Katie Stubblefield is still adjusting to life with her new face, which includes learning how to talk again. (Source: ABC News: Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yGCGPj

Social communication assessment after TBI: a narrative review of innovations in pragmatic and discourse assessment methods - Steel J, Togher L.

BACKGROUND: Social communication assessment after traumatic brain injury (TBI) remains a challenging area within speech-language pathology (SLP) clinical practice. Difficulties include the lack of TBI-specific standardized assessment instruments and limite... (Source: SafetyLit)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ym2lNG

WATCH: A speech therapy session with US's youngest face transplant recipient

A year after her surgery, Katie Stubblefield is still adjusting to life with her new face, which includes learning how to talk again. (Source: ABC News: Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yGCGPj

Walter Reed Army Institute of Research begins phase 1 clinical trial of Marburg vaccine

(Walter Reed Army Institute of Research) WRAIR this week administered the first vaccine in a Phase 1 clinical trial to evaluate the safety and immunogenicity of a Marburg vaccine candidate in healthy adult volunteers. The WRAIR study evaluates the VRC-MARADC087-00-VP vaccine, developed by the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The Marburg virus is in the same family as Ebola and causes severe hemorrhagic fever in humans. (Source: EurekAlert! - Infectious and Emerging Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OWVdRD

Walter Reed Army Institute of Research begins phase 1 clinical trial of Marburg vaccine

(Walter Reed Army Institute of Research) WRAIR this week administered the first vaccine in a Phase 1 clinical trial to evaluate the safety and immunogenicity of a Marburg vaccine candidate in healthy adult volunteers. The WRAIR study evaluates the VRC-MARADC087-00-VP vaccine, developed by the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The Marburg virus is in the same family as Ebola and causes severe hemorrhagic fever in humans. (Source: EurekAlert! - Infectious and Emerging Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OWVdRD

Asthma During Pregnancy Tied to Postpartum Depression Risk Asthma During Pregnancy Tied to Postpartum Depression Risk

Women who have asthma during their pregnancies are more likely to experience postpartum depression after delivery, a large Canadian study suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yGiugt

Asthma During Pregnancy Tied to Postpartum Depression Risk Asthma During Pregnancy Tied to Postpartum Depression Risk

Women who have asthma during their pregnancies are more likely to experience postpartum depression after delivery, a large Canadian study suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yGiugt

PTEN Status Predicts Prostate Cancer Outcomes as Well as Multigene Panel PTEN Status Predicts Prostate Cancer Outcomes as Well as Multigene Panel

PTEN loss by tumor immunohistochemistry (IHC) predicts prostate-cancer outcomes after radical prostatectomy as well as a commercial multigene panel does.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yiFMK2

Complications and loss of free flaps after reconstructions for oral cancer

The aim of this retrospective study was to analyse the incidence of complications and loss of flaps after primary reconstructions for oral cancer in 191 patients at our hospital over the five years 2005–2010. The patients' clinical and personal details, characteristics of the tumours, types of microvascular flap, complications, and outcomes were recorded. The soft tissue flaps used most often were the fasciocutaneous radial forearm free flap (RFFF) (n=86, 45%) and the anterolateral thigh free flap (ALTFF) (n=48, 25%) while the most commonly used osseous flap was the deep circumflex iliac artery flap (DCIA) (n=25, 13%).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OrQbx3

Vascularised fatty tissue: its role in prevention of the symptoms of Frey syndrome after parotidectomy

We studied 37 consecutive patients who had parotidectomies between 2008 and 2017 and who had vascular fat flaps inserted to replace the excised parotid tissue and prevent Frey syndrome. They were followed up for 1–9 years to check for the relevant symptoms. We studied 17 female and 20 male patients, mean age 52 (range 19–78) years. The flaps took a maximum of 17minutes to dissect. There was no donor site morbidity, the vascular fat flap was stable in all cases for up to nine years, and none of the patients complained of symptoms of Frey syndrome.

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Anterior convex lateral orbital wall: distinctive morphology in Apert syndrome

Bony malformations of the orbit and alterations to the soft tissue in Apert syndrome contribute to ophthalmic dysfunction. Recognised structural malformation of the sphenoid and ethmoid sinuses, together with corresponding deformities in the anterior and middle cranial base, are characteristic. Our aim was to explore the underlying structural components of disfigurement and the consequent development of the orbit in patients with Apert syndrome over time by studying 18 preoperative computed tomographic (CT) scans of affected patients and 36 scans from controls.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IZrmCu

Complications and loss of free flaps after reconstructions for oral cancer

The aim of this retrospective study was to analyse the incidence of complications and loss of flaps after primary reconstructions for oral cancer in 191 patients at our hospital over the five years 2005–2010. The patients' clinical and personal details, characteristics of the tumours, types of microvascular flap, complications, and outcomes were recorded. The soft tissue flaps used most often were the fasciocutaneous radial forearm free flap (RFFF) (n=86, 45%) and the anterolateral thigh free flap (ALTFF) (n=48, 25%) while the most commonly used osseous flap was the deep circumflex iliac artery flap (DCIA) (n=25, 13%).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OrQbx3

Vascularised fatty tissue: its role in prevention of the symptoms of Frey syndrome after parotidectomy

We studied 37 consecutive patients who had parotidectomies between 2008 and 2017 and who had vascular fat flaps inserted to replace the excised parotid tissue and prevent Frey syndrome. They were followed up for 1–9 years to check for the relevant symptoms. We studied 17 female and 20 male patients, mean age 52 (range 19–78) years. The flaps took a maximum of 17minutes to dissect. There was no donor site morbidity, the vascular fat flap was stable in all cases for up to nine years, and none of the patients complained of symptoms of Frey syndrome.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J46LgB

New method for retention of glasses while operating

Wearers of glasses often complain that their glasses slip down the nose in theatre, which leads to discomfort and a reduced visual field, and (occasionally) they fall into the surgical wound. Here I describe a simple, quick, clean way to secure glasses without the need for straps, which pull straight back on the nose and can be uncomfortable.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OswEMW

Anterior convex lateral orbital wall: distinctive morphology in Apert syndrome

Bony malformations of the orbit and alterations to the soft tissue in Apert syndrome contribute to ophthalmic dysfunction. Recognised structural malformation of the sphenoid and ethmoid sinuses, together with corresponding deformities in the anterior and middle cranial base, are characteristic. Our aim was to explore the underlying structural components of disfigurement and the consequent development of the orbit in patients with Apert syndrome over time by studying 18 preoperative computed tomographic (CT) scans of affected patients and 36 scans from controls.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IZrmCu

What Is the Best Timing for Endoscopic and Radiographic Surveillance Following Sinonasal Malignancies Treatment?

Close, routine endoscopic and imaging surveillance is needed in the post-treatment setting. (Source: ENTtoday - TRIO Best Practices)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OYQv5K

What Is the Best Timing for Endoscopic and Radiographic Surveillance Following Sinonasal Malignancies Treatment?

Close, routine endoscopic and imaging surveillance is needed in the post-treatment setting. (Source: ENTtoday - TRIO Best Practices)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OYQv5K

Impact of Data Presentation on Physician Performance Utilizing Artificial Intelligence-Based Computer-Aided Diagnosis and Decision Support Systems

Abstract

Ultrasound (US) is a valuable imaging modality used to detect primary breast malignancy. However, radiologists have a limited ability to distinguish between benign and malignant lesions on US, leading to false-positive and false-negative results, which limit the positive predictive value of lesions sent for biopsy (PPV3) and specificity. A recent study demonstrated that incorporating an AI-based decision support (DS) system into US image analysis could help improve US diagnostic performance. While the DS system is promising, its efficacy in terms of its impact also needs to be measured when integrated into existing clinical workflows. The current study evaluates workflow schemas for DS integration and its impact on diagnostic accuracy. The impact on two different reading methodologies, sequential and independent, was assessed. This study demonstrates significant accuracy differences between the two workflow schemas as measured by area under the receiver operating curve (AUC), as well as inter-operator variability differences as measured by Kendall's tau-b. This evaluation has practical implications on the utilization of such technologies in diagnostic environments as compared to previous studies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ynTf33

“Sodium bicarbonate”: an adjunct to painless palatal anesthesia

ConclusionEffect of sodium bicarbonate on reducing pain while injecting into the palatal aspect was noted in this study. (Source: Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NIUwXd

Impact of Data Presentation on Physician Performance Utilizing Artificial Intelligence-Based Computer-Aided Diagnosis and Decision Support Systems

Abstract

Ultrasound (US) is a valuable imaging modality used to detect primary breast malignancy. However, radiologists have a limited ability to distinguish between benign and malignant lesions on US, leading to false-positive and false-negative results, which limit the positive predictive value of lesions sent for biopsy (PPV3) and specificity. A recent study demonstrated that incorporating an AI-based decision support (DS) system into US image analysis could help improve US diagnostic performance. While the DS system is promising, its efficacy in terms of its impact also needs to be measured when integrated into existing clinical workflows. The current study evaluates workflow schemas for DS integration and its impact on diagnostic accuracy. The impact on two different reading methodologies, sequential and independent, was assessed. This study demonstrates significant accuracy differences between the two workflow schemas as measured by area under the receiver operating curve (AUC), as well as inter-operator variability differences as measured by Kendall's tau-b. This evaluation has practical implications on the utilization of such technologies in diagnostic environments as compared to previous studies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ynTf33

“Sodium bicarbonate”: an adjunct to painless palatal anesthesia

ConclusionEffect of sodium bicarbonate on reducing pain while injecting into the palatal aspect was noted in this study. (Source: Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NIUwXd

Asthma During Pregnancy Tied to Postpartum Depression Risk Asthma During Pregnancy Tied to Postpartum Depression Risk

Women who have asthma during their pregnancies are more likely to experience postpartum depression after delivery, a large Canadian study suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yGiugt

PTEN Status Predicts Prostate Cancer Outcomes as Well as Multigene Panel PTEN Status Predicts Prostate Cancer Outcomes as Well as Multigene Panel

PTEN loss by tumor immunohistochemistry (IHC) predicts prostate-cancer outcomes after radical prostatectomy as well as a commercial multigene panel does.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yiFMK2

Recipe: How to make a natural, allergy-busting smoothie

(Natural News) A runny nose, watery eyes, and wheezy breath can only mean one thing: seasonal allergies are back. If those over-the-counter-drops and sprays aren't doing it anymore, then you should consider maintaining a well-stocked pantry as well. Nature has blessed us with a vast selection of pure ingredients that can be mixed and matched... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yIOd0C

Parents advised to use out-of-date EpiPens, but call 999, as shortage continues

NHS England has written to parents and carers of children that use  EpiPen Jr, advising on them on what to do in the event of a severe allergic or anaphylactic reaction as the shortage of EpiPens continues (Source: The Pharmaceutical Journal)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ackejm

Revisiting the role of the slit-skin smear in the diagnosis of Indian post-kala-azar dermal leishmaniasis

Conclusion: Such evidence based medicine helps minimize intuition, systematize clinical experience and provides a diagnostic rationale as sufficient grounds for a clinical decision. (Source: Indian Journal of Dermatology, Venereology and Leprology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QQNe5O

Asthma During Pregnancy Tied to Postpartum Depression Risk Asthma During Pregnancy Tied to Postpartum Depression Risk

Women who have asthma during their pregnancies are more likely to experience postpartum depression after delivery, a large Canadian study suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yGiugt

PTEN Status Predicts Prostate Cancer Outcomes as Well as Multigene Panel PTEN Status Predicts Prostate Cancer Outcomes as Well as Multigene Panel

PTEN loss by tumor immunohistochemistry (IHC) predicts prostate-cancer outcomes after radical prostatectomy as well as a commercial multigene panel does.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yiFMK2

Recipe: How to make a natural, allergy-busting smoothie

(Natural News) A runny nose, watery eyes, and wheezy breath can only mean one thing: seasonal allergies are back. If those over-the-counter-drops and sprays aren't doing it anymore, then you should consider maintaining a well-stocked pantry as well. Nature has blessed us with a vast selection of pure ingredients that can be mixed and matched... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yIOd0C

Parents advised to use out-of-date EpiPens, but call 999, as shortage continues

NHS England has written to parents and carers of children that use  EpiPen Jr, advising on them on what to do in the event of a severe allergic or anaphylactic reaction as the shortage of EpiPens continues (Source: The Pharmaceutical Journal)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ackejm

Revisiting the role of the slit-skin smear in the diagnosis of Indian post-kala-azar dermal leishmaniasis

Conclusion: Such evidence based medicine helps minimize intuition, systematize clinical experience and provides a diagnostic rationale as sufficient grounds for a clinical decision. (Source: Indian Journal of Dermatology, Venereology and Leprology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QQNe5O

AN E-CIGARETTE COMPANY PUT VIAGRA AND CIALIS IN ITS VAPING LIQUIDS, AND THE FDA IS NOT PLEASED

A vape company, HelloCig Electronic Technology Co., has included Viagra and Cialis in its liquids, and has raised the ire of the Food and […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ymNxhM

AN E-CIGARETTE COMPANY PUT VIAGRA AND CIALIS IN ITS VAPING LIQUIDS, AND THE FDA IS NOT PLEASED

A vape company, HelloCig Electronic Technology Co., has included Viagra and Cialis in its liquids, and has raised the ire of the Food and […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ymNxhM

Asthma During Pregnancy Tied to Postpartum Depression Risk Asthma During Pregnancy Tied to Postpartum Depression Risk

Women who have asthma during their pregnancies are more likely to experience postpartum depression after delivery, a large Canadian study suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yGiugt

Recipe: How to make a natural, allergy-busting smoothie

(Natural News) A runny nose, watery eyes, and wheezy breath can only mean one thing: seasonal allergies are back. If those over-the-counter-drops and sprays aren't doing it anymore, then you should consider maintaining a well-stocked pantry as well. Nature has blessed us with a vast selection of pure ingredients that can be mixed and matched... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yIOd0C

PTEN Status Predicts Prostate Cancer Outcomes as Well as Multigene Panel PTEN Status Predicts Prostate Cancer Outcomes as Well as Multigene Panel

PTEN loss by tumor immunohistochemistry (IHC) predicts prostate-cancer outcomes after radical prostatectomy as well as a commercial multigene panel does.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yiFMK2

Recipe: How to make a natural, allergy-busting smoothie

(Natural News) A runny nose, watery eyes, and wheezy breath can only mean one thing: seasonal allergies are back. If those over-the-counter-drops and sprays aren't doing it anymore, then you should consider maintaining a well-stocked pantry as well. Nature has blessed us with a vast selection of pure ingredients that can be mixed and matched... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yIOd0C

AN E-CIGARETTE COMPANY PUT VIAGRA AND CIALIS IN ITS VAPING LIQUIDS, AND THE FDA IS NOT PLEASED

A vape company, HelloCig Electronic Technology Co., has included Viagra and Cialis in its liquids, and has raised the ire of the Food and […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ymNxhM

2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes

Elizabeth M. Kolawole, Rakieb Andargachew, Baoyu Liu, Jesica R. Jacobs, Brian D. Evavold (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUh1NN

Alpha2beta1 Integrin (VLA-2) Protects Activated Human Effector T Cells From Methotrexate-Induced Apoptosis

Amna Abderrazak, Mohammed-Amine El Azreq, Dalila Naci, Paul R. Fortin, Fawzi Aoudjit (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P06QXX

Immuno-informatics Analysis to Identify Novel Vaccine Candidates and Design of a Multi-Epitope Based Vaccine Candidate Against Theileria parasites

Prajna Parimita Kar, Anand Srivastava (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PvmMy9

Comparison between gold nanoparticles and FITC as the labelling in lateral flow immunoassays for rapid detection of Ralstonia solanacearum

Volume 29, Issue 1, December 2018, Page 1074-1085 . (Source: Food and Agricultural Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PzPle9

Anti ‐allergic activity of mung bean (Vigna radiata (L.) Wilczek) protein hydrolysates produced by enzymatic hydrolysis using non‐gastrointestinal and gastrointestinal enzymes

Journal of Food Biochemistry, EarlyView. (Source: Journal of Food Biochemistry)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P1GPYf

Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice

Volume 29, Issue 1, December 2018, Page 1116-1125 . (Source: Food and Agricultural Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PC0Y48

Ultrasensitive detection of Bisphenol A based on an aptasensor with DNA amplification

Volume 29, Issue 1, December 2018, Page 1106-1115 . (Source: Food and Agricultural Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P4V5iK

Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Volume 29, Issue 1, December 2018, Page 1086-1105 . (Source: Food and Agricultural Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PBmQgb

2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes

Elizabeth M. Kolawole, Rakieb Andargachew, Baoyu Liu, Jesica R. Jacobs, Brian D. Evavold (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUh1NN

The Impact of Invariant NKT Cells in Sterile Inflammation: The Possible Contribution of the Alarmin/Cytokine IL-33

Maroua Haroun Ferhat, Aur élie Robin, Louise Barbier, Antoine Thierry, Jean-Marc Gombert, Alice Barbarin, André Herbelin (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PEv7Qx

Alpha2beta1 Integrin (VLA-2) Protects Activated Human Effector T Cells From Methotrexate-Induced Apoptosis

Amna Abderrazak, Mohammed-Amine El Azreq, Dalila Naci, Paul R. Fortin, Fawzi Aoudjit (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P06QXX

Immuno-informatics Analysis to Identify Novel Vaccine Candidates and Design of a Multi-Epitope Based Vaccine Candidate Against Theileria parasites

Prajna Parimita Kar, Anand Srivastava (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PvmMy9

Editorial: Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference

Steven P. Templeton, Amariliz Rivera, Bernard Hube, Ilse D. Jacobsen (Source: Frontiers in Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P2mBh4

Comparison between gold nanoparticles and FITC as the labelling in lateral flow immunoassays for rapid detection of Ralstonia solanacearum

Volume 29, Issue 1, December 2018, Page 1074-1085 . (Source: Food and Agricultural Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PzPle9

Anti ‐allergic activity of mung bean (Vigna radiata (L.) Wilczek) protein hydrolysates produced by enzymatic hydrolysis using non‐gastrointestinal and gastrointestinal enzymes

Journal of Food Biochemistry, EarlyView. (Source: Journal of Food Biochemistry)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P1GPYf

Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice

Volume 29, Issue 1, December 2018, Page 1116-1125 . (Source: Food and Agricultural Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PC0Y48

Ultrasensitive detection of Bisphenol A based on an aptasensor with DNA amplification

Volume 29, Issue 1, December 2018, Page 1106-1115 . (Source: Food and Agricultural Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P4V5iK

Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Volume 29, Issue 1, December 2018, Page 1086-1105 . (Source: Food and Agricultural Immunology)

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Introducing the craniocervical Y-ligament

Abstract

Purpose

We examined the accessory atlantoaxial ligaments and found them to be a part of a complex ligamentous structure, which we named craniocervical Y-ligament with respect to its shape.

Methods

The ligaments of the upper cervical spine were dissected in ten Thiel embalmed human cadavers. Origin and attachment of the Y-ligament were described and a detailed photo and video-documentation was carried out with the head in the neutral position, flexion, extension and rotation to study the ligament during these movements.

Results

The Y-ligaments were found to be paired and symmetric in all specimens. The shape of the ligament is similar to an Y, its lateral arm connecting the atlas to the axis, its medial arm connecting the occipital bone to the axis, fusing with the two main ligaments, the alar and transverse ligaments. The lateral arm of the Y-ligament was found to be analogous to the accessory atlantoaxial ligament. During cervical flexion, both arms of the Y-ligament became taut while extension made the Y-ligaments relaxed. During rotation both Y-ligaments became taut, moving in the opposite directions in the sagittal plane while following the gliding movements of the lateral masses of the atlas.

Conclusions

The craniocervical Y-ligament is a complex ligamentous structure and has a constant anatomy. Because of its shape and special arrangement, it probably plays a role in limiting both atlantooccipital and atlantoaxial movements. Acknowledgement of this ligamentous structure will help understand upper cervical stability. The present study should serve as a basis for future biomechanical and radiological studies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OqYpoR

Introducing the craniocervical Y-ligament

Abstract

Purpose

We examined the accessory atlantoaxial ligaments and found them to be a part of a complex ligamentous structure, which we named craniocervical Y-ligament with respect to its shape.

Methods

The ligaments of the upper cervical spine were dissected in ten Thiel embalmed human cadavers. Origin and attachment of the Y-ligament were described and a detailed photo and video-documentation was carried out with the head in the neutral position, flexion, extension and rotation to study the ligament during these movements.

Results

The Y-ligaments were found to be paired and symmetric in all specimens. The shape of the ligament is similar to an Y, its lateral arm connecting the atlas to the axis, its medial arm connecting the occipital bone to the axis, fusing with the two main ligaments, the alar and transverse ligaments. The lateral arm of the Y-ligament was found to be analogous to the accessory atlantoaxial ligament. During cervical flexion, both arms of the Y-ligament became taut while extension made the Y-ligaments relaxed. During rotation both Y-ligaments became taut, moving in the opposite directions in the sagittal plane while following the gliding movements of the lateral masses of the atlas.

Conclusions

The craniocervical Y-ligament is a complex ligamentous structure and has a constant anatomy. Because of its shape and special arrangement, it probably plays a role in limiting both atlantooccipital and atlantoaxial movements. Acknowledgement of this ligamentous structure will help understand upper cervical stability. The present study should serve as a basis for future biomechanical and radiological studies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OqYpoR

“Sodium bicarbonate”: an adjunct to painless palatal anesthesia

Abstract

Purpose

It is believed that whenever we inject local anesthesia into the palate it is a painful experience for the patients. The aim of this study was to make palatal anesthesia painless by adding 7.4% sodium bicarbonate as an adjunct in local anesthesia.

Methods

Fifty subjects requiring extraction of maxillary bilateral premolar teeth for orthodontic purpose free from periapical infections. These extractions were divided in such a way that all right-sided extractions were done under 2% lignocaine with 1:80,000 adrenaline; and all left-sided extractions were done under 2% lignocaine with 1:80,000 adrenaline with 7.4% sodium bicarbonate added. All extractions were performed using a consistent intra-alveolar technique by a single operator. Both the patient and the operator were blinded to the contents of the local anesthetic solution. Data records of these patients were procured on the basis of VAS and VRS, requirement of repeated injection, and onset and duration of anesthesia.

Results

Clinical and statistical data confirmed that the addition of sodium bicarbonate in local anesthetics reduces pain and decreased the onset and increased duration of local anesthesia in the palatal site, as compared to injection of local anesthetic without sodium bicarbonate.

Conclusion

Effect of sodium bicarbonate on reducing pain while injecting into the palatal aspect was noted in this study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yEP7ed

“Sodium bicarbonate”: an adjunct to painless palatal anesthesia

Abstract

Purpose

It is believed that whenever we inject local anesthesia into the palate it is a painful experience for the patients. The aim of this study was to make palatal anesthesia painless by adding 7.4% sodium bicarbonate as an adjunct in local anesthesia.

Methods

Fifty subjects requiring extraction of maxillary bilateral premolar teeth for orthodontic purpose free from periapical infections. These extractions were divided in such a way that all right-sided extractions were done under 2% lignocaine with 1:80,000 adrenaline; and all left-sided extractions were done under 2% lignocaine with 1:80,000 adrenaline with 7.4% sodium bicarbonate added. All extractions were performed using a consistent intra-alveolar technique by a single operator. Both the patient and the operator were blinded to the contents of the local anesthetic solution. Data records of these patients were procured on the basis of VAS and VRS, requirement of repeated injection, and onset and duration of anesthesia.

Results

Clinical and statistical data confirmed that the addition of sodium bicarbonate in local anesthetics reduces pain and decreased the onset and increased duration of local anesthesia in the palatal site, as compared to injection of local anesthetic without sodium bicarbonate.

Conclusion

Effect of sodium bicarbonate on reducing pain while injecting into the palatal aspect was noted in this study.

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Accurate Age Determination for Adolescents Using Magnetic Resonance Imaging of the Hand and Wrist with an Artificial Neural Network-Based Approach

Abstract

This study proposes an accurate method in assessing chronological age of the adolescents using a machine learning approach using MRI images. We also examined the value of MRI with Tanner-Whitehouse 3 (TW3) method in assessing skeletal maturity. Seventy-nine 12–17-year-old healthy Hong Kong Chinese adolescents were recruited. The left hand and wrist region were scanned by a dedicated skeletal MRI scanner. T1-weighted three-dimensional coronal view images for the left hand and wrist region were acquired. Independent maturity indicators such as subject body height, body weight, bone marrow composition intensity quantified by MRI, and TW3 skeletal age were included for artificial neural network (ANN) analysis. Our results indicated that the skeletal age was generally underestimated using TW3 method, and significant difference (p < 0.05) was noted for skeletal age with chronological age for female category and at later stage of adolescence (15 to 17 years old) in both genders. In our proposed machine learning approach, ages determined by ANN method agreed well with chronological age (p > 0.05).The machine learning approach using ANN method was about 10-fold more accurate than the TW3 method using MRI alone. It offers a more objective and accurate solution for prospective chronological maturity assessment for adolescents.

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